CONTAINER HAVING A BOTTOM PROVIDED WITH AN ARCH A STEP

Récipient (1) en matière plastique, muni d'un corps (5) et d'un fond (6) s'étendant à partir d'une extrémité inférieure du corps (5), le fond (6) comprenant : - une assise (7) périphérique définissant un plan (8) de pose ; - une voûte (10) concave qui s'étend à partir d'une zone (11) centrale jusqu'à l'assise (7) ; - une série de rainures (13) principales de renfort, formées en creux dans la voûte, qui s'étendent radialement à partir de la zone (11) centrale jusqu'à l'assise (7) au moins, et qui subdivisent la voûte en une série de secteurs (15) angulaires, chaque rainure (13) étant bordée latéralement, à sa jonction avec chaque secteur (15) de la voûte (10) qui lui est adjacent, par une nervure (18) de renfort qui s'étend en saillie par rapport audit secteur (15).

CONTAINER HAVING A BOTTOM PROVIDED WITH AN ARCHED [...] HAS

RESONATOR HAS WAVES OF VOLUME EXPLOITING the EXCITATION/DETECTION OF the VIBRATION

L'invention concerne un résonateur à ondes acoustiques de volume configuré pour résonner à une fréquence de travail prédéterminée comprenant : - un support (12), comprenant une première face (14) et une deuxième face (16), - un substrat résonnant (18), comprenant une première face (20) et une deuxième face (22), et - une membrane (24), reliant rigidement,d'une part, la deuxième face (16) du support et, d'autre part, la première face (20) du substrat résonnant. Le support comprend une cavité interne (28), et une électrode interne (32), de sorte à former une zone d'entrefer (34) entre l'électrode interne (24) et une portion (35) de la membrane. Le substrat résonnant est configuré pour générer entre sa première face et sa deuxième face des ondes acoustiques à mode longitudinal vibrant à la fréquence de travail du résonateur, lorsqu'un champ électrostatique ayant une composante sinusoïdale à la fréquence de travail est généré dans la zone d'entrefer par application d'une tension différentielle ...

PROCEEDED OF MICROPOSITIONNEMENT HAS MULTI DEGREES OF FREEDOM FOR PIEZOELECTRIC ACTUATORS AND DEVICE ASSOCIATES

Le domaine technique de l'invention est celui des méthodes de positionnement d'actionneurs, notamment piézoélectriques et a plus particulièrement pour objet un actionneur piézoélectrique, ledit actionneur piézoélectrique comprenant au moins un matériau piézoélectrique apte à se déformer lorsqu'il est soumis à un champ électrique, caractérisé en ce qu'il comprend les étapes suivantes : une étape simultanée : • de commande de l'actionneur piézoélectrique par application d'un champ électrique audit actionneur piézoélectrique de sorte à déformer le matériau piézoélectrique ; et • de mesure d'une variation de charge électrique accumulée sur l'actionneur piézoélectrique résultant de la déformation ; - au moins une étape d'acquisition des mesures de la variation de charge électrique, de traitement de ces acquisitions et d'estimation d'un déplacement de l'actionneur piézoélectrique et/ou d'une force appliquée à partir de ladite mesure de la variation de charge électrique accumulée sur l'actionneur ...

MICRO-ACTIONNEUR AND MICRO-PINCE

RESONATOR HAS WAVES OF VOLUME EXPLOITING the EXCITATION/DETECTION OF the VIBRATION

MICROPOSITIONING METHOD OF MULTI DEGREES OF FREEDOM FOR PIEZOELECTRIC ACTUATORS AND ASSOCIATED DEVICE

MICRO-ACTIONNEUR AND MICRO-PINCE

L'invention concerne un micro-actionneur comprenant un bras d'actionnement (4) comprenant au moins une première couche (8) ayant un premier coefficient de dilatation thermique et une seconde couche (10) ayant un second coefficient de dilatation thermique, le second coefficient de dilatation thermique étant différent du premier coefficient de dilatation thermique; et un dispositif d'entrainement (6) en déplacement du bras d'actionnement (4) comprenant un dispositif calorifique (26, 28, 30) propre à échanger de la chaleur avec moins une partie dudit bras d'actionnement (4) pour occasionner le déplacement du bras d'actionnement (4) par flexion dudit bras d'actionnement (4); caractérisé en ce que la première couche (8) est réalisée dans un matériau piézo-électrique. L'invention concerne également une micro-pince associée.

An arrangement for driving a vehicle

... 993,341. Turbines. TORETSKY GOSUDARSTVENNY MASHINOSTROITELNY ZAVOD. June 14, 1963, No. 23820/63. Heading FIT. [Also in Division B7] A vehicle for working in mines is propelled from the energy stored in a flywheel set in motion by an air turbine. The flywheel 1, which is rotatably mounted in a casing 5 and is connected through clutches and gearing to the vehicle wheels, is connected to the rotor 3 of the turbine which is associated with air jets 6 from a manifold 7 provided on the cover 4 of the casing which is also provided with exhaust ports 9 which are closed when the vehicle is in motion. The flywheel is set in motion from a fixed air supply in the mine.

OTP burning method and microcontroller

The invention provides an OTP (One Time Programmable) burning method and a microcontroller. A program storage space and a data storage space are defined, a plurality of calibration point spaces are defined in the data storage space, and each calibration point space is used for storing an address of calibration data and actual calibration data; selecting a calibration point; calling an OTP burning program; reading the value of the address 0, and obtaining the address of the current effective calibration data according to the value of the address 0; counting the calibrated times; if the number of times is smaller than the threshold value of the number of times of calibration, adding 1 to the address, writing new calibration data into the new address, storing the new calibration data at the address 0, completing burning, and exiting the OTP burning program; and if the number is equal to the calibration number threshold, prompting an error. According to the method, the address is allocated ...

Process for triphosphate oligonucleotide synthesis

The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5′-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5′-triphosphate oligonucleotide synthesis.

METHOD AND APPARATUS FOR INSPECTION OF LIGHT EMITTING SEMICONDUCTOR DEVICES USING PHOTOLUMINESCENCE IMAGING

A method and apparatus for the inspection of light emitting semiconductor devices. The semiconductor device is illuminated with a light source, wherein at least an area of the light emitting semiconductor is illuminated with a waveband of light. The waveband of light λA+λB can generate electron-hole pairs in the light emitting semiconductor to be inspected. Through an objective lens at least a part of the light λC emitted by the light emitting semiconductor is detected. The emitted light is captured with a sensor of a camera that is sensitive to wavelengths of the emitted light, wherein the wavelength of the emitted light is above the width of the waveband. The data of the emitted light, captured with the sensor, are transmitted to a computer system for calculating inspection results of the light emitting semiconductor. 1. A method for inspection of light emitting semiconductor devices , comprising the following steps:{'sub': A', 'B, 'illuminating with a light source at least an area of the light emitting semiconductor with a waveband of light, wherein the waveband of light λ+λcan generate electron-hole pairs in the light emitting semiconductor to be inspected;'}{'sub': 'C', 'detecting through an objective lens at least a part of the light λemitted by the light emitting semiconductor, wherein the emitted light is captured with a sensor of a camera that is sensitive to wavelengths of the emitted light and the wavelength of the emitted light is above the a width of the waveband; and'}transferring data of the emitted light, captured with the sensor, to a computer system for calculating inspection results of light emitting semiconductor.2. The method of claim 1 , wherein the light source illuminates the area of the light emitting semiconductor directly with the waveband of light λ+λfor illumination which is generated by a plurality of LEDs of the light source.3. The method of claim 2 , wherein a second filter is positioned in a detection beam path after the objective ...

Flexible, scratch resistant radiation curable inkjet inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds includes a) no more than 15 wt % of one or more monofunctional acrylates wherein the homopolymer thereof has a T g smaller than 20° C.; and b) at least 45 wt % of a mixture of monomers consisting of b1) 10 to 45 wt % of a N-vinyl lactam and/or a vinylether acrylate; and b2) 10 to 45 wt % of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt % are based on the total weight of the inkjet ink; and wherein the T g is determined by the DSC method in ISO 11357-2:1999.

ENHANCEMENT MODE FIELD EFFECT DEVICE AND THE METHOD OF PRODUCTION THEREOF

A method is disclosed for producing Group III-N field-effect devices, such as HEMT, MOSHFET, MISHFET or MESFET devices, comprising two active layers, e.g. a GaN/AlGaN layer. The method produces an enhancement mode device of this type, i.e. a normally-off device, by providing a passivation layer on the AlGaN layer, etching a hole in the passivation layer and not in the layers underlying the passivation layer, and depositing the gate contact in the hole, while the source and drain are deposited directly on the passivation layer. The characteristics of the active layers and/or of the gate are chosen such that no two-dimensional electron gas layer is present underneath the gate, when a zero voltage is applied to the gate. A device with this behavior is also disclosed. 1. A method of fabricating a semiconductor device , the method comprising:depositing a first active layer on a substrate;depositing a second active layer on the first active layer, the second active layer having a higher band-gap than the first active layer;depositing a passivation layer on the second active layer;depositing a source electrode and a drain electrode in direct electrical contact with the passivation layer;etching at least one hole in the passivation layer, the at least one hole being located between the source and drain electrode and not protruding into the layers underlying the passivation layer; anddepositing a gate contact in the hole.2. The method according to claim 1 , whereinthe second active layer has a composition, thickness and stress such that a two-dimensional electron gas layer is absent between the first active layer and the second active layer, when no additional layers are deposited on the second active layer,and wherein the passivation layer is applied in such a way and has material characteristics such that a two-dimensional electron gas is created between the first and the second active layer, after deposition of the passivation layer,and wherein the gate contact is applied ...

Conformationally restricted dinucleotide monomers and oligonucleotides

This invention relates to conformationally locked dinucleotide motifs for exo- and phosphate stabilization. For instance, oligonucleotides can be prepared having one or more of the following formulas (IV-IX).

ORGANIC LIGHT-EMITTING DISPLAY APPARATUS

An organic light-emitting display apparatus includes: a substrate; a pixel electrode above the substrate; an intermediate layer above the pixel electrode and comprising an organic emission layer; an opposite electrode above the intermediate layer; and an encapsulation structure above the opposite electrode and comprising at least one inorganic film and at least one organic film. A difference between a refractive index of the at least one inorganic film and a refractive index of the at least one organic film is in a range between about 0.3 to about 0.5. A thickness of the at least one inorganic film is in a range of about 0.7 μm to about 1.5 μm. A thickness of the at least one organic film is in a range of about 3.5 μm to about 6.5 μm. 1. An organic light-emitting display apparatus comprising:a substrate;a pixel electrode above the substrate;an intermediate layer above the pixel electrode and comprising an organic emission layer;an opposite electrode above the intermediate layer; andan encapsulation structure above the opposite electrode and comprising at least one inorganic film and at least one organic film,wherein a difference between a refractive index of the at least one inorganic film and a refractive index of the at least one organic film is in a range between about 0.3 to about 0.5,a thickness of the at least one inorganic film is in a range of about 0.7 μm to about 1.5 μm, anda thickness of the at least one organic film is in a range of about 3.5 μm to about 6.5 μm.2. The organic light-emitting display apparatus of claim 1 , wherein the encapsulation structure comprises a first inorganic film claim 1 , a first organic film claim 1 , and a second inorganic film claim 1 , which are sequentially stacked above the opposite electrode.3. The organic light-emitting display apparatus of claim 1 , wherein the at least one inorganic film comprises silicon nitride (SiN).4. The organic light-emitting display apparatus of claim 1 , further comprising:a capping layer ...

HETEROGENEOUS PROPPANT PLACEMENT IN A FRACTURE WITH REMOVABLE CHANNELANT FILL

A method of heterogeneous proppant placement in a subterranean fracture is disclosed. The method comprises injecting well treatment fluid including proppant () and proppant-spacing filler material called a channelant () through a wellbore () into the fracture (), heterogeneously placing the proppant in the fracture in a plurality of proppant clusters or islands () spaced apart by the channelant (), and removing the channelant filler material () to form open channels () around the pillars () for fluid flow from the formation () through the fracture () toward the wellbore (). The proppant and channelant can be segregated within the well treatment fluid, or segregated during placement in the fracture. The channelant can be dissolvable particles, initially acting as a filler material during placement of the proppant in the fracture, and later dissolving to leave the flow channels between the proppant pillars. The well treatment fluid can include fibers to provide reinforcement and consolidation of the proppant and, additionally or alternatively, to inhibit settling of the proppant in the treatment fluid. 1. A method , comprising:introducing a well treatment fluid comprising proppant and fiber through a wellbore and into a fracture in a subterranean formation; andforming a plurality of proppant clusters comprising proppant and fiber in the fracture;wherein the fiber consolidates the proppant into clusters, andwherein the fiber degrades.2. The method of claim 1 , wherein the fiber degrades by softening claim 1 , dissolving claim 1 , or reacting claim 1 , and wherein the fiber degrades after proppant placement in the fracture.3. The method of claim 2 , wherein the fiber degradation enables fluid flow from the formation through the fracture toward the wellbore.4. The method of claim 1 , wherein the fiber comprises at least one of:a solid acid-precursor capable of generating acid in the fracture, and,a solid base-precursor capable of generating generate a base in the ...

DISPLAY DEVICE AND A METHOD OF MANUFACTURING THE SAME

A display device includes a substrate, a pixel electrode, an encapsulation layer, and a light-shielding layer. The pixel electrode is positioned above the substrate. The encapsulation layer is disposed over the pixel electrode. The encapsulation layer includes a first inorganic layer. The first inorganic layer includes a plurality of fine pillar patterns. The pillar patterns are sloped with respect to one surface of the substrate. The light-shielding layer is disposed on the encapsulation layer. The light-shielding layer includes a first opening. The first opening overlaps at least a portion of the pixel electrode. 1. A display device , comprising:a substrate;a pixel electrode positioned above the substrate;an encapsulation layer disposed above the pixel electrode and comprising a first inorganic layer, the first inorganic layer comprising a plurality of fine pillar patterns sloping with respect to one surface of the substrate; anda light-shielding layer disposed on the encapsulation layer and comprising a first opening, the first opening overlapping at least a portion of the pixel electrode.2. The display device of claim 1 , wherein the encapsulation layer comprises at least one inorganic layer comprising the first inorganic layer claim 1 , and wherein the first inorganic layer is adjacent to the light-shielding layer.3. The display device of claim 1 , wherein the first inorganic layer comprises silicon oxide.4. The display device of claim 1 , wherein the first inorganic layer has a refractive index ranging from about 1.0 to about 1.5.5. The display device of claim 1 , wherein the first inorganic layer is porous.6. The display device of claim 1 , wherein the encapsulation layer further comprises a second inorganic layer claim 1 , and wherein the second inorganic layer is in direct contact with the first inorganic layer.7. The display device of claim 6 , wherein the second inorganic layer has a refractive index greater than a refractive index of the first inorganic ...

MULTI DIRECTIONAL ILLUMINATION FOR A MICROSCOPE AND MICROSCOPE

A dome illumination for a microscope and a microscope are disclosed. At least one objective lens carries a dome at a free end, wherein the free end of the objective lens is facing a surface of the object. At least one light source is arranged such that an illumination is provided to the dome when the objective lens is positioned in an optical axis or working position of the microscope. 1. An illumination for a microscope comprising:at least one objective lens defining a free end which is facing a surface of an object;a dome is mounted to the free end of the at least one objective lens; andat least one light source is arranged such that an illumination is provided to the dome when the objective lens is positioned in an optical axis.2. The illumination for a microscope of claim 1 , wherein the objective lens has a ring shaped mirror arranged in a dark field illumination path claim 1 , wherein a reflective surface of the ring shaped mirror is formed such that incident light from the at least one light source is reflected towards an inner surface of the dome.3. The illumination for a microscope of claim 2 , wherein the inner surface of the dome is coated with some highly reflective diffuse material and formed such that the light is scattered towards the object.4. The illumination for a microscope of claim 2 , wherein an additional light source is arranged such that light from the additional light source shines under the dome onto the surface of the object.5. The illumination for a microscope of claim 4 , wherein the additional light source is a ring light.6. The illumination for a microscope of claim 2 , wherein the dome is made from a highly reflective and diffuse material.7. Illumination for a microscope of claim 1 , wherein the at least one light source is an external light source being arranged such that an external light impinging on the dome is scattered towards the object.8. The illumination for a microscope of claim 7 , wherein the dome is made of transparent ...

Chiral design

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Quaternary n-(halomethyl) ammonium salts as therapeutic agents

The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated N-methyl substituent as a therapeutic agent against leishmaniasis had not been reported. The compounds described here, in specific those with a terminal arylalkenyl or diarylalkenyl moiety, are shown to inhibit the growth of Leishmania panamensis parasites, a known causative agent of leishmaniasis disease. In addition, the series of compounds are also extensive against malaria, Chagas disease, toxoplasmosis, and other parasitic diseases.

POLYURETHANE FOAM FORMING COMPOSITIONS

The present invention relates to the field of polyol components suitable for forming polyurethane foam, in particular two component polyurethane foam the resulting foams and methods for their production. The present inventors found gaseous hydrohaloolefin containing polyol components possessing improved shelf-life properties, in particular polyol components comprising a gaseous hydrohaloolefin blowing agent, a nitrogen catalyst and a tin catalyst, wherein the tin catalyst comprises a sulfur atom. The present inventors also found that the shelf-life is further improved if the nitrogen catalyst is at least partially protonated by reaction with an acid, such as an organic acid. 1. A polyol component suitable for producing two component polyurethane foam wherein the polyol component comprises a polyol; a gaseous hydrohaloolefin blowing agent; a nitrogen catalyst; and a tin catalyst , wherein the tin catalyst comprises a sulfur atom , wherein the gaseous hydrohaloolefin blowing agent is selected from 1 ,3 ,3 ,3-tetrafluoropropene (HFO 1234ze); 2 ,3 ,3 ,3-tetrafluoroprop-1-ene (HFO 1234yf); 1 ,2 ,3 ,3 ,3-pentafluoropropene (HFO 1225ye); 1 ,1 ,3 ,3 ,3-pentafluoropropene (HFO 1225zc); 1 ,1 ,2 ,3 ,3-pentafluoropropene (HFO 1225yc); or a combination thereof.2. The polyol component according to claim 1 , wherein the polyol is selected from the group consisting of a sucrose containing polyol; phenol claim 1 , a phenol formaldehyde containing polyol; a glucose containing polyol; a sorbitol containing polyol; a methylglucoside containing polyol; an aromatic polyester polyol; an aliphatic polyester polyol; an aromatic polyether polyol; an aliphatic polyether polyol; a polybutadiene polyol; a polycaprolactone polyol; a polycarbonate polyol; a hydroxyl terminated polyolefin polyol; a graft polyol; glycerol; ethylene glycol; diethylene glycol; propylene glycol-containing polyol; graft copolymers of polyether polyols with a vinyl polymer; a copolymer of a polyether polyol with a ...

OBJECT CARRIER, SYSTEM AND METHOD FOR BACK LIGHT INSPECTION

An object carrier, a system and a method is disclosed for the back light inspection of transparent or semitransparent objects. The carrier has a carrier base layer with photo luminescent properties which carries the transparent or semitransparent object on top of the layer. The transparent or semitransparent object could be a wafer and the object carrier could be a wafer chuck. At least one light source being arranged above the object carrier such that excitation light emitted from the at least one light source is directed through the transparent or semitransparent object to the layer with photo luminescent properties. The light returned from the layer with photo luminescent properties is collected by an objective and registered by a sensor. 1. An object carrier for back light inspection of a transparent or semitransparent object , comprising:a carrier base; and,a first layer with photo luminescent properties for carrying the transparent or semitransparent object on top of the layer.2. The object carrier of claim 1 , wherein the first layer with photo luminescent properties comprises a bulk layer with photo luminescent properties and a reflective coating at a side of the first layer which faces the carrier base.3. The object carrier of claim 2 , wherein the bulk layer is a porous layer.4. The object carrier of claim 3 , further comprising a vacuum means mounted to the porous layer so that a vacuum force is applied to the object through pores of the bulk layer.5. The object carrier of claim 2 , wherein the reflective coating is an aluminum coating.6. The object carrier of claim 1 , wherein the first layer comprises:a glass plate with a photo luminescent coating; and,a reflective coating on a side of the photo luminescent coating facing the carrier base.7. The object carrier of claim 6 , wherein the reflective coating is an aluminum coating.8. The object carrier of claim 6 , wherein photo luminescent coating is made of phosphor.9. The object carrier of claim 6 , ...

Dispensing system for mixture of two components and static mixing nozzle therefor

Dispensing system for dispensing a mixture of a first component and a second component, the dispensing system comprising: (i) a dispensing gun comprising an inlet body with a first passage for feeding in the first component under pressure and a second passage for feeding in the second component under pressure, the first and second passages respectively comprising a closable first outlet and a closable second outlet, which may be operable by means of a handle or trigger of the dispensing gun; (ii) a static mixing nozzle, detachably connectable to the outlets of the body and provided for mixing and dispensing the components, the static mixing nozzle comprising a first section containing a first chamber and a second chamber for conducting the first and second component respectively and a second section, subsequent to the first section (in forwards flow direction), containing a mixing chamber with static mixing elements which promote mixing the first and second components and conducting the mixture to a nozzle tip serving as an outlet for the mixture. According to the invention, at least one of the first and second chambers of the static mixing nozzle contains a series of static backflow prevention elements, arranged for hindering backflow of the respective component within the respective chamber. 2. The dispensing system according to claim 1 , wherein the series of static backflow prevention elements is formed by a plurality of walls claim 1 , dividing the respective chamber up into at least two compartments.3. The dispensing system according to claim 2 , wherein the compartments have a volume of 50 to 400 mm.4. The dispensing system according to claim 2 , wherein the plurality of walls comprise two alternating sets of walls which protrude into the chamber from two opposing side walls of the chamber.5. The dispensing system according to claim 2 , wherein the walls are arranged in a slanting direction with respect to the forwards flow direction of the respective ...

APPARATUS AND METHOD FOR PRODUCING AND DISPENSING A REACTION MIXTURE

Apparatuses for producing and dispensing a reaction mixture include a mixing head for mixing the reaction components that are fed via two supply lines. The apparatuses also include a decompression system to relieve pressure from the supply lines to avoid the reaction components seeping into the mixing head. The decompression system includes two pressure vessels each with two sides, separated by a membrane. One of these sides forms an expansion chamber for the reaction component, while the other side is connected to a pneumatic system. With this pneumatic system, the expansion chamber can be pressurized before the production of the reaction mixture. After the production of the reaction mixture, the pressure can be relieved. 1. An apparatus for producing and dispensing a reaction mixture starting from at least a first reaction component and a second reaction component that are under a first pressure in a first container and a second pressure in a second container respectively , the apparatus comprising:a mixing head configured for mutually mixing said first reaction component and said second reaction component, wherein the mixing head comprises an outlet configured for the mixture of first and second reaction components;a first supply line configured for feeding the first reaction component from said first container under the first pressure prevailing therein to the mixing head;a second supply line configured for feeding the second reaction component from said second container under the second pressure prevailing therein to the mixing head;a first shut-off valve in said first supply line and a second shut-off valve in said second supply line, the first shut-off valve and the second shut-off valve each having an open position and a closed position;a third shut-off valve configured for shutting off the first supply line in said mixing head and a fourth shut-off valve configured for shutting off the second supply line in said mixing head, the third shut-off valve and the ...

METHOD AND SYSTEM FOR MONITORING CRYSTALLIZATION OF AMORPHOUS SILICON THIN FILM, AND METHOD OF MANUFACTURING THIN FILM TRANSISTOR BY USING THE METHOD AND SYSTEM

A method and system for monitoring crystallization of an amorphous silicon (a-Si) thin film, and a method of manufacturing a thin film transistor (TFT) by using the method and system are disclosed. The method of monitoring the crystallization of the a-Si thin film includes: irradiating light from a light source onto a monitoring a-Si thin film to anneal the monitoring a-Si thin film; annealing the monitoring a-Si thin film and concurrently measuring a Raman scattering spectrum of light scattered by the monitoring a-Si thin film at set time intervals; and calculating a crystallization characteristic value of the monitoring a-Si thin film based on the Raman scattering spectrum. 1. A method of monitoring crystallization of an amorphous silicon (a-Si) thin film , the method comprising:irradiating light from a light source onto a monitoring a-Si thin film to anneal the monitoring a-Si thin film;annealing the monitoring a-Si thin film and concurrently measuring a Raman scattering spectrum of light scattered by the monitoring a-Si thin film at set time intervals; andcalculating a crystallization characteristic value of the monitoring a-Si thin film based on the Raman scattering spectrum.2. The method of claim 1 , wherein the light source is a Raman scattering inducement laser.3. The method of claim 2 , wherein the Raman scattering inducement laser produces a laser beam having a power higher than or equal to 10 mW.4. The method of claim 1 , wherein the monitoring a-Si thin film is deposited by performing chemical vapor deposition (CVD).5. The method of claim 1 , wherein the calculating of the crystallization characteristic value of the monitoring a-Si thin film comprises:calculating a peak ratio between an amorphous Si peak and a polycrystalline Si peak from the Raman scattering spectrum at each of the time intervals;plotting the peak ratios to form a peak ratio pattern graph; andcalculating an attenuation parameter value of an exponential decay formula as the ...

Chiral control

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Radiation curable inkjet fluids and inks improved for photoyellowing

A radiation curable inkjet fluid including a radiation curable composition comprising at least 25 wt% of a vinylether acrylate and at least 15 wt% of a polymerizable compound comprising at least three acrylate groups; and a photoinitiator comprising a tertiary amine group and 0 to 3 wt% of isopropylthioxanthone. An inkjet printing method is also disclosed.

Device for the fixation of bones

The device for the fixation of bones is intended for surgical treatment of open fractures and pseudo-joints in the region of long tubular bones (femur, tibia, etc.) as well as distraction thereof. It comprises two parallel sliding rails (1) connected to each other by transverse pieces (2). The sliding rails are intended to hold displaceable slides (3) provided with bushes (4) in order to align the drills for drilling through bones and holding screws, as well as with openings (8) for supporting compression devices. The movable slides (3) permit the bone screws or nails to be inserted at the particular sites which are most favourable for the treatment and to be fixed there. <IMAGE>

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Device and apparatus for the simultaneous detection of multiple analytes

Flexible, Scratch Resistant Radiation Curable Inkjet Inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including at least 45 wt% of a mixture of monomers consisting of: a) 10 to 35 wt% of one or more cyclic monofunctional acrylates wherein the homopolymer thereof has a T g larger than 20° C; b) 10 to 30 wt% of a N-vinyl lactam and/or a vinylether acrylate ; c) 10 to 30 wt% of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt% are based on the total weight of the inkjet ink. An inkjet printing method is also disclosed

Flexible, Scratch Resistant Radiation Curable Inkjets Inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including a) no more than 15 wt% of one or more monofunctional acrylates wherein the homopolymer thereof has a Tg smaller than 20° C; and b) at least 45 wt% of a mixture of monomers consisting of b1) 10 to 45 wt% of a N-vinyl lactam and/or a vinylether acrylate; and b2) 10 to 45 wt% of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt% are based on the total weight of the inkjet ink. An inkjet printing method is also disclosed

Flexible, scratch resistant radiation curable inkjet inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including a) no more than 15 wt% of one or more monofunctional acrylates wherein the homopolymer thereof has a T g smaller than 20°C; and b) at least 45 wt% of a mixture of monomers consisting of b1) 10 to 45 wt% of a N-vinyl lactam and/or a vinylether acrylate; and b2) 10 to 45 wt% of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt% are based on the total weight of the inkjet ink; and wherein the T g is determined by the DSC method in ISO 11357-2:1999. An inkjet printing method is also disclosed.

Flexible, scratch resistant radiation curable inkjet inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including at least 45 wt% of a mixture of monomers consisting of: a) 10 to 35 wt% of one or more cyclic monofunctional acrylates wherein the homopolymer thereof has a T g larger than 20°C; b) 10 to 30 wt% of a N-vinyl lactam and/or a vinylether acrylate; c) 10 to 30 wt% of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt% are based on the total weight of the inkjet ink; and wherein the T g is determined by the DSC method in ISO 11357-2:1999. An inkjet printing method is also disclosed.

Stable non-aqueous inkjet printing inks

Stable non-aqueous inkjet inks

A non-aqueous inkjet ink include a pigment and a mixture of at least two polyalkyleneglycol dialkylethers represented by Formula (I): wherein, R 1 and R 2 are each independently selected from an alkyl group having 1 to 4 carbon atoms; Y represents an ethylene group or a propylene group; wherein n is an integer selected from 4 to 20 for a first polyalkyleneglycol dialkylether; and n is an integer selected from 5 to 20 for a second polyalkyleneglycol dialkylether. A method for preparing a non-aqueous inkjet ink is also provided.

Stable non-aqueous inkjet inks

A non-aqueous inkjet ink comprising a pigment and a mixture of at least two polyalkyleneglycol dialkylethers represented by Formula (I): wherein, R1 and R2 are each independently selected from an alkyl group having 1 to 4 carbon atoms; Y represents an ethylene group or a propylene group; wherein n is an integer selected from 4 to 20 for a first polyalkyleneglycol dialkylether; and n is an integer selected from 5 to 20 for a second polyalkyleneglycol dialkylether. A method for preparing a non-aqueous inkjet ink is also disclosed.

Inkjet inks comprising inorganic pigments

A colour inkjet ink including an inorganic colour pigment having a colour selected from the group consisting of cyan, magenta, yellow, blue, green, red, orange, violet and brown; and at least 1 wt% of an inorganic colourless pigment based on the total weight of the colour inkjet ink, wherein the inorganic colourless pigment has a smaller average particle size than the inorganic colour pigment.

Stable non-aqueous inkjet inks

A non-aqueous inkjet ink includes a pigment and a mixture of at least two polyalkyleneglycol dialkylethers represented by Formula (I): wherein, R1 and R2 are each independently selected from an alkyl group having 1 to 4 carbon atoms; Y represents an ethylene group or a propylene group; wherein n is an integer selected from 4 to 20 for a first polyalkyleneglycol dialkylether; and n is an integer selected from 5 to 20 for a second polyalkyleneglycol dialkylether. A method for preparing a non-aqueous inkjet ink is also provided.

Radiation curable inkjet fluids and inks improved for photoyellowing

Reversirtm compounds

The present invention relates, in general to agents that modulate the pharmacological activity of conjugated siRNAs.

Multi-targeted single entity conjugates

The present invention relates, in general to, compounds, compositions and methods useful for modulating gene expression of multiple target nucleic acids by a single chemical entity.

Multi-targeted single entity conjugates

The present invention relates to a multi-targeted molecule comprising a first double-stranded siRNA molecule and a second double-stranded siRNA molecule, wherein the first siRNA and the second siRNA are covalently linked to each other, and wherein at least one ligand is conjugated with the multi-targeted molecule.

5′-end derivatives

The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Reversir tm compounds

Lubricant for cold metal press-working

5' phosphate mimics

The present invention provides nucleosides and oligonucleotides comprising a 5' phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Chiral control

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Chiral design

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Chiral control

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

Process for triphosphate oligonucleotide synthesis

The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5'-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5 '-triphosphate oligonucleotide synthesis.

5' phosphate mimics

The present invention provides nucleosides and oligonucleotides comprising a 5' phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

5'-end derivatives

The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Conformationally restricted dinucleotide monomers and oligonucleotides

This invention relates to conformationally locked dinucleotide motifs for exo- and phosphate stabilization. For instance, oligonucleotides can be prepared having one or more of the following formulas (IV-IX).

Extrahepatic delivery

One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.

Circular sirnas

One aspect of the present invention relates to a small circular interfering RNA (sciRNA) comprising a sense strand and an antisense strand, each of said sense and antisense strands comprising at least one nucleic acid modification, optionally wherein the sense strand has a circular or substantially circular structure. Other aspects of the invention relate a pharmaceutical composition and a method for inhibiting the expression of a target gene in a subject using the sciRNA.

2'-modified nucleoside based oligonucleotide prodrugs

This invention relates to an oligonucleotide comprising one or more 2'-modified nucleosides, wherein the 2'-position of the nucleoside has a structure of formula (I). The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein. The invention also relates to a method of bioactivating an oligonucleotide comprising one or more 2'-modified nucleosides, wherein the 2'-position of the nucleoside is modified by a bio-cleavable linking group, wherein the bio-cleavable linking group comprises acetal, disulfide, carbamate, amide, sulfonamide, a biocleavable carbohydrate linker, or combinations thereof, said method comprising the step of: exposing the oligonucleotide to a physiological condition that causes the bio-cleavable linking group to be cleaved from the 2'-modified nucleoside, thereby regenerating the 2'-OH group of the nucleoside.

Method of preparing alkylphosphoric surface active compounds

Subbing layers for use with thermographic materials

A substantially light-insensitive black and white thermographic material comprising a polymeric or polymer-coated support, a subbing layer on the support and on the same side of the support as the subbing layer a thermosensitive element containing a substantially light-insensitive organic silver salt, a reducing agent therefor in thermal working relationship therewith and a binder, characterized in that the subbing layer contains a binder, less than 20% by weight of silica and covalently bonded acid groups in the binder, if present, are either substantially present as free acid or substantially present as acid salts and has a leachable non-fluoro-halide ion content into water at room temperature over a period of 120 minutes of less than 0. 6mg/m 2 ; and a process for producing the substantially light-insensitive thermographic material comprising the steps of: coating the support with a subbing layer-composition thereby forming the subbing layer; producing one or more aqueous coating compositions together containing the substantially light-insensitive organic silver salt, the reducing agent and the binder; and applying the one or more aqueous coating compositions to the same side of the support as the subbing layer thereby forming after drying the thermosensitive element.

PROCESS FOR THE PREPARATION OF NEW CATALYSTS CONTAINING RHODIUM

LES COMPOSES (M-HYDRAZINE-N :N)-BISBIS(TRIPHENYLPHOSPHINE)CHLORORHODIUM (I) ET DICHLORURE DE DI(M-HYDRAZINE-N :N)-BISBIS(TRIPHENYLPHOSPHINE)RHODIUM (I), QUI SONT LES CATALYSEURS D'HYDROGENATION HOMOGENE ET LEUR APPLICATION DANS L'HYDROGENATION DU GROUPE METHYLENE EXOCYCLIQUE DE SELS D'ADDITION D'ACIDE DE LA 6-DEMETHYL-6-DESOXY-6-METHYLENE-5-HYDROXYTETRACYCLINE (METHACYCLINE) POUR LA PREPARATION DE L'A-6-DESOXY-5-HYDROXYTETRACYCLINE (DOXYCYCLINE). COMPOUNDS (M-HYDRAZINE-N: N) -BISBIS (TRIPHENYLPHOSPHINE) CHLORORHODIUM (I) AND DI DICHLORIDE (M-HYDRAZINE-N: N) -BISBIS (TRIPHENYLPHOSPHINE) RHODIUM (I), WHICH ARE THE CATALYSTS HOMOGENEOUS AND THEIR APPLICATION IN THE HYDROGENATION OF THE EXOCYCLIC METHYLENE GROUP OF 6-DEMETHYL-6-DESOXY-6-METHYLENE-5-HYDROXYTETRACYCLINE ACID ADDITION SALTS FOR THE PREPARATION OF A-6- DESOXY-5-HYDROXYTETRACYCLINE (DOXYCYCLINE).

Flexible, scratch resistant radiation curable inkjet inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including a) no more than 15 wt% of one or more monofunctional acrylates wherein the homopolymer thereof has a Tg smaller than 20°C; and b) at least 45 wt% of a mixture of monomers consisting of b1) 10 to 45 wt% of a N-vinyl lactam and/or a vinylether acrylate; and b2) 10 to 45 wt% of an ethoxylated and/or propoxylated polyacrylate having a molecular weight of at least 450; wherein all wt% are based on the total weight of the inkjet ink; and wherein the Tg is determined by the DSC method in ISO 11357-2:1999. An inkjet printing method is also disclosed.

HYDROGENATION RHODIUM CATALYSTS, THEIR PREPARATION AND THEIR APPLICATION

Vacuum oscillator

RHODIUM HYDRATION CATALYSTS.

Chiral design.

<p>COMPOSICIÓN DE OLIGONUCLÉOTIDOS QUIRÁLMENTE CONTROLADOS; Y MÉTODO PARA EL CORTE CONTROLADO DE UN POLÍMERO DE ÁCIDO NUCLEICO</p> <p> COMPOSITION OF QUIRACELY CONTROLLED OLIGONUCLÉOTIDOS; AND METHOD FOR THE CONTROLLED CUTTING OF A NUCLEIC ACID POLYMER </p>

Chiral design

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary seqeunce of a nucleic acid polymer.

Accumulator battery electrode block assembly method - sorts electrodes according to thickness and groups plus and minus electrodes into required groups

The electrode groups are stacked according to thickness, packaging in insulating separation material and assorting of plus and minus electrodes in a given sequence. Prior to the sequencing of electrodes the electrodes are sorted in an uneven number of groups, i.e. thin, medium, and thick ones. In the grouping of the electrodes the two middle ones form the sum thickness of the side ones, i.e. a thin and a thick one. The stacks of the middle thickness electrodes are arranged sequentially with the same polarity, while the stacks of the equidistant thin and thick electrodes are only arranged in pairs. Then an electrode from each stack is picked up and shifted into a horizontal position. Subsequently such electrodes are formed into a block of given thickness.

Chiral design

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Haptens, immunogens, antibodies and conjugates for 2-oxo-3-hydroxy LSD

Extrahepatic delivery

One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.

Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use

The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Actuating device for adaptive optics instruments

The present invention relates to an actuating device for adaptive optics instruments. This actuating device comprises a plurality of electric contacts to each of which a control voltage is applied and at least an actuating circuit element, which is electrically connected to at least two of said electric contacts. The aforesaid actuating circuit element provides an actuating voltage that is variable in the space, moving along said actuating circuit element. This actuating voltage is adapted to cause the deformation of a deformable optical element, which is operatively associated with the actuating device.

Preparation of flumethasone and its 17-carboxyl androsten analogue.

Apparatus for thermally processing substrate

An apparatus for thermally processing a plurality of substrates including a process chamber into which a boat having a plurality of substrates stacked thereon is loaded, and a heater chamber separate from the process chamber and having a plurality of heaters to apply heat to the process chamber. Here, the heaters are installed to correspond to all sides of the plurality of substrates. Therefore, it is possible to minimize a temperature distribution in the process chamber and uniformly supply heat to the entire region of the plurality of substrates.

Housing for connection to both broadband and narrowband networks as a shelf in a telecommunications rack

An architecture, as well as various components, of an asynchronous transfer mode (ATM) subscriber access multiplexer (ASAM) system can be implemented using an xDSL (x-Digital Subscriber Line) using DMT (Discrete Multitone) or CAP (Carrierless Amplitude Phase Modulation) between a plurality of subscribers and a corresponding plurality of line termination equipment in a shelf that also includes network termination equipment for connection to an ATM network. The line termination and network termination equipment are interconnected by a bus internal to the shelf for providing subscriber access. Separate lowpass filters are provided at each end of a twisted wire pair between the shelf and each subscriber equipment. A shelf can be used as a hub for connecting to a remote shelf that includes the line termination equipment for connection to subscribers. Although the internal bus of the shelf is shown in a non-redundant embodiment, an increased level of equipment protection can be provided by placing one half of a redundant equipment pair in one shelf and the other half in the other shelf and sharing network termination equipment between such shelves.

Canister for deposition apparatus, and deposition apparatus and method using the same

Device and apparatus for the simultaneous detection of multiple analytes

Process for the preparation of alpha-ketol derivatives

TO (TRIPHENYLPHOSPHINE) HYDRAZINOMETHOXYRHODIUM (I) AND THE USE THEREOF AS A CATALYST FOR STEREOSPECIFIC HYDRATION.

Dried tetramethoxysilane sol-gel containing a leachable reagent

First and second reactants that give a signal when mixed in the presence of an analyte in a liquid sample, are separately contained in sol-gels that release the reactants in the presence of the liquid. For example, when the first and second reactants respectively comprise an oxidant and a reductant, and the reaction provides a detectable signal, the system can be used to detect the presence of contaminants in a water sample. The sol-gel may be obtained by reaction of water with, per part by volume thereof, at least 2 parts of a metal alkoxide, and drying the resultant gel.

PROCESS FOR THE PREPARATION OF ALKALINE POLYMETAPHOSPHATE COMPLEXES FROM ALPHA-6-DESOXY-5-HYDROXYTETRACYCLIN

Fermentation process and isolation of the active products obtained by it

Liquid dispensing apparatus

Liquid dispensing apparatus comprises a support member which supports a movably mounted dispensing member. The support member is movable between first and second positions. A single drive system causes the dispensing member to move relative to the support member to a number of dispense positions while the support member is in its first position and causes the support member to move to the second position.

METHOD OF PREPARING METACYCLINE BY DEHALOGENING AN ACID ADDITION SALT OF 11A-CHLORO-6-DESOXY-6-DEMETHYL-6-METHYLENE-5-HYDROXYTETRACYCLINE

Preparation of flumethasone and its 17-carboxyl androsten analogue

Process for preparing flumethasone (6.alpha.,9.alpha.-difluoro-11(3,17.alpha.,21-trihydroxy-16.alpha.-methyl-pregna-1,4-diene-3,20-dione), flumethasone 21-acetate or its 17-carboxyl androsten analogue of the formula: which process comprises (a) reacting a compound of formula (II) 18 with benzoyl chloride to form a 3-enolic ester of the formula (IIIa): b) reacting the enol benzoate (IIIa) with an electrophilic fluorination agent to introduce fluorine in the C6- position to form a compound of formula (IIIb): 19 (c) deprotecting the compound (IIIb) at C3 to form a compound of formula (IV): (d) fluorinating the 9,11-epoxy group of compound IV by reacting it with hydrofluoric acid to yield flumethasone 21-acetate; and optionally (e) hydrolysing the flumethasone 21-acetate, in the presence or absence of an oxidising agent, to yield compound (I) or flumethasone, respectively.

Method for forming polycrystalline silicon layer and thin film transistor and organic light emitting device including the polycrystalline silicon layer

Gelatinous recording material

Imaging method for arrayed molecules

A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with respect to the array; (ii) by reference to the first molecule, aligning inspection windows in registration with the discrete reaction sites; and (iii) determining the amount of detectable signal in each window. The method is used to locate the reaction site; accurately on the array, and to correct for any misalignments.

Synthetic methods and derivatives of triphosphate oligonucleotides

The invention features a oligonucleotide of formula (I) or pharmaceutically acceptable salts, or prodrugs thereof: (I) which are capable of inducing an anti-viral or an antibacterial response, in particular, the induction of type I IFN, IL-18 and/or IL-1β by binding to RIG-1. The invention relates to methods of making and using modified oligonucleotide comprising at least one triphosphate or analogs thereof. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

(Glyco) proteins with high immunoreactivity and a process for their preparation

The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81 %, preferably >90 %. The inventive monoclonal antibodies are produced using a fluidized bed reactor in conjunction with a conventional protein-chemical purification method or preferably with a purification method involving less column chromatography. The monoclonal antibodies thus produced are suitable, in gamma -irradiated form, e.g. Tc-99m labelled, for the in vivo diagnosis of inflammatory diseases and bone marrow metastases. In alpha - or beta -irradiated form, e.g. astatine or Re-188 or Y-90 labelled form, the inventive monoclonal antibodies can be used, for example, in the treatment of leukaemia.

Assay device processing instrument

An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.

Phenethanolamine-derived haptens, immunogens and conjugates comprising them and antibodies recognising said immunogenes and conjugates

The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays for the detection of ractopamine, isoxsuprine and ritodrine. The haptens are prepared by reacting a phenylethanolamine derivative of formula D with a phenylalkylcarbonyl derivative of formula E: in which, in formula I, Z 1 is a crosslinker and Z 2 is H and, in formula II, Z 1 is H and Z 2 is a crosslinker.

Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use

The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

Flexible, scratch resistant radiation curable inkjet inks

A free radical radiation curable inkjet ink containing a photoinitiator and polymerizable compounds including a) no more than 15 wt% of one or more monofunctional acrylates wherein the homopolymer thereof has a T

Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines

Process for treatment n-phenyl-n-/1,3-dimethylbutyl/-p-phenylendiamine melt

Riešenie sa týká sposobu úpravy taveniny N-fenyl-N‘- (1,3-dimetylbutyl) -p-fenyléndiamínu pre přípravu tvarovo stálých častíc. Tavenina N-fenyl-N‘-(l,3-dimetylbutyl)-p-fenyléndiamínu, připadne s prídavkorn N-fenyl-N‘- (1,3-dimetylbutyl)-p-fenyléndiamínu v práškovej formě, sa upraví na teplotu maximálně 44 °C, za miešania sa pri tejto teplote udržuje až do dosiahnutia dostatečného stupňa kryštalizácie — do vytvorenia nukleačných centier. Potom sa teplota zvýši na maximálně 48 °C, homogénna krystalická masa sa udržuje pri tejto teplote a tvaruje sa pri teplote maximálně 30 °C do róznych tvarov. Produkt sa používá ako antioxidačný prostriedok. The solution relates to a method of melt treatment N-phenyl-N '- (1,3-dimethylbutyl) -p-phenylenediamine to prepare shape-stable particles. N-phenyl-N - (1,3-dimethylbutyl) -p-phenylenediamine melt, with additive N-phenyl-N '- (1,3-dimethylbutyl) -p-phenylenediamine in powder form, is adjusted to at a maximum temperature of 44 ° C; maintains this temperature until sufficient degree of crystallization - to formation nucleation centers. Then the temperature to a maximum of 48 ° C, homogeneous the crystalline mass is maintained at that temperature and molded at a maximum temperature of 30 ° C into various shapes. The product is used as antioxidant.

(Photo) thermographic material with improved transport performance

A (photo)thermographic recording material comprising a (photo-addressable) thermosensitive element on one side of a water resistant support and an outermost backside layer on the other side of the water resistant support, the (photo-addressable) thermosensitive element comprising a substantially light-insensitive organic silver salt, an organic reducing agent for the substantially light-insensitive organic silver salt in thermal working relationship therewith(, photosensitive silver halide in catalytic association with the substantially light insensitive organic silver salt) and a binder and the outermost backside layer comprising polymeric beads, characterized in that an outermost layer on the side of the water resistant support with the (photo-addressable) thermosensitive element does not contain a fluorine-containing polymeric surfactant and the static frictional coefficient between the outermost layer on the side of the water resistant support with the (photo-addressable) thermosensitive element and the outermost backside layer is ≦0.24 and/or the outermost backside layer of the (photo)thermographic recording material has an R 2 determined according to DIN 4768/1 of >1.75 μm; and a (photo)thermographic recording process therefor.

Radioactive complex for diagnostic visualization of neoplastic tissues

A B S T R A C T This invention relates to a preparation for the diagnostic visuali-zation of neoplastic tissues, i.e. tumors and metastases, by means of tissue scintigraphy. The preparation of this invention consists essentially of an injectable complex of 99mTechnetium or IIIIndium with a dicarboxylic or tri-carboxylic acid of the general formula in which n is 1 or 2, R1 and R2 together are an oxygen atom or the ?CH-COOH group or R1 is a hydrogen atom or a hydroxyl or amino group and R2 is a hydro-gen atom or one of the following groups: -CH2-COOH -CHOH-COOH -CO-COOH, or with a water soluble salt of the same, in sterile aqueous solution having a physiologically harmless pH value.

Electrocoating bath control

Synthetic methods and derivatives of triphosphate oligonucleotides

The invention features a oligonucleotide of formula (I) or pharmaceutically acceptable salts, or prodrugs thereof: (I) which are capable of inducing an anti-viral or an antibacterial response, in particular, the induction of type I IFN, IL-18 and/or IL-1β by binding to RIG-1. The invention relates to methods of making and using modified oligonucleotide comprising at least one triphosphate or analogs thereof. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

Rnai agents modified at the 4'-c-position

One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene in vivo . The dsRNA duplex comprises one or more 4'-modifications in one or both strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for in vivo therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g. , for the treatment of various disease conditions.

Replacable printed board assembly (pba)

An architecture, as well as various components, of an asynchronous transfer mode (ATM) subscriber access multiplexer (ASAM) system can be implemented using an xDSL (x-Digital Subscriber Line) using DMT (Discrete Multitone) or CAP (Carrierless Amplitude Phase Modulation) between a plurality of subscribers and a corresponding plurality of line termination equipment in a shelf that also includes network termination equipment for connection to an ATM network. The line termination and network termination equipment are interconnected by a bus internal to the shelf for providing subscriber access. Separate lowpass filters are provided at each end of a twisted wire pair between the shelf and each subscriber equipment. A shelf can be used as a hub for connecting to a remote shelf that includes the line termination equipment for connection to subscribers. Although the internal bus of the shelf is shown in a non-redundant embodiment, an increased level of equipment protection can be provided by placing one half of a redundant equipment pair in one shelf and the other half in the other shelf and sharing network termination equipment between such shelves.

General-purpose hydraulic system

Process of selective solvolysis

The 17 alpha -monoesters and 17 alpha ,21-diesters of corticosteriods are well known and represent nowadays the most efficient group of anti-inflammatory compounds for topical application, having minimal systemic action.

Method and system for data synchronization

A system for monitoring includes: multiple EEG sensors spatially positioned on a layer of tissue for capturing EEG signals of a patient; multiple amplifiers coupled with the EEG sensors for amplifying the captured signals; and a low frequency oscillator for generating a synchronizing signal which is distributed to the amplifiers for synchronizing the digitization of the captured signals; wherein each amplifier includes: a voltage controlled oscillator for an adjustable frequency reference; an analog to digital converter for converting the amplified signal to a digital value; and a microcontroller for controlling the frequency of the voltage controlled oscillator and operation of the analog to digital converter by using the synchronizing signal.

Flexible, Scratch Resistant Radiation Curable Inkjet Inks

Polymetaphosphate complexes of alpha-6-deoxy-5-hydroxytetracycline

Smart pen and display device using the same

The present disclosure relates to a smart pen and a display device using the same, in which a reflective light reception rate may be enhanced through a light output structure to increase a code pattern and code information recognition rate of a display panel. According to an embodiment of the disclosure, smart pen comprising a body portion, a pen tip portion formed on one end of the body portion to form a path of light emitted from a light emitting portion in an end direction at one side, a code detector detecting shape data for code patterns by applying light to the pen tip portion and receiving light reflected from a display panel and the pen tip portion, and a code processor generating coordinate data by using the shape data and transmitting the coordinate data to a main processor for driving the display panel.

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