24-04-2014 дата публикации
Номер: US20140113012A1
The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes. 2. The method of claim 1 , wherein{'sup': 1', '2', '2, '(a) Lis a bond, Lis —C(O)NH—, ring B is phenyl, Ris —CN or phenyl, and subscript m is 1, or'}{'sup': 1', '2', '1, 'sub': '2', '(b) Ris —C(O)OH, subscript n is 1, ring A is phenyl, Lis —C(O)NH—, and Lis a bond or —CH—, or'}{'sup': 1', '2', '2, 'sub': '2', '(c) each of ring A and ring B is phenyl, Ris —C(O)OH or combined with L, subscript n is 1, and at least one Ris selected from the group consisting of H, —CN and —COH.'}5. The method of claim 4 , wherein each Ris independently selected from the group consisting of —C(O)R claim 4 , —C(O)OR claim 4 , Calkyl-C(O)OR claim 4 , —NRC(O)OR claim 4 , —NRC(O)NRR claim 4 , —SOOR claim 4 , —SONRR claim 4 , —NRSOR claim 4 , and —CN.6. The method of claim 4 , wherein each Ris independently selected from the group consisting of —CH—C(O)OH claim 4 , —C(O)Me claim 4 , —NHC(O)NH claim 4 , —NHC(O)OMe claim 4 , —NHSOMe claim 4 , —SONH claim 4 , —SONHMe claim 4 , —SOH claim 4 , —C(O)OH claim 4 , and —CN.7. The method of claim 4 , whereinring A is phenyl; andsubscript n is 1.8. The method of claim 4 , whereinring A is selected from the group consisting of biphenyl and pyridyl, orsubscript n is 2.11. The method of claim 10 , wherein each Ris independently selected from the group consisting of H claim 10 , —CHNHCONH claim 10 , —CHNHCOOMe claim 10 , —CHNHMe claim 10 , —CHOPh claim 10 , 2-CN claim 10 , 4-CN claim 10 , —C(O)OH claim 10 , —CONHOH claim 10 , —OCF2H claim 10 , —POH claim 10 , —SOH claim 10 , phenyl claim 10 , pyridyl claim 10 , imidazole and tetrazole.13. The method of claim 12 , wherein{'sup': '2', 'sub': 2', '2', '2', '2', '2', '2', '2', '2, 'each Ris independently selected from the group consisting of H, Me, —Cl, —CHOH, —CHCHOH, —CHNH, —C(O)Me, —C(O)OH, —C(O)NH, —CN, morpoholine, 3,4-difluorophenyl and —SONH; ...
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