Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization

Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

Osteoimplant and method for making same

Bone matrix compositions and methods

Ramp-shaped intervertebral implant

İmplantasyon için kemiğini işlenmesi yöntemi ve elde edilen kemik

Polyurethanes for Osteoimplants

Implant, method of making same and use of the implant for the treatment of bone defects

An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.

INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS

An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

Spinal intervertebral implant, interconnections for such implant and processes for making

Delivery system attachment

Synthesis of a bone-polymer composite material

Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

Biocompatible osteogenic band for repair of spinal disorders

POLYURETHANES FOR OSTEOIMPLANTS

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

BONE MATRIX COMPOSITIONS AND METHODS

Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized ...

Biocompatible osteogenic band for repair of spinal disorders

Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.

Osteogenic implants derived from bone

Osteogenic implants derived from bone

Polyurethanes for osteoimplants

Cell permeable structural implant

DELIVERY SYSTEM ATTACHMENT

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Bone matrix compositions and methods

Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized ...

Biocompatible osteogenic band for repair of spinal disorders

Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.

Method of treating and dehydrating bone for implantation and resulting bone

Delivery system attachment

INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS

An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

BONE MATRIX COMPOSITIONS AND METHODS

Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoin-ductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized ...

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

PROCESS FOR SELECTING BONE FOR TRANSPLANTATION

POLYURETHANES FOR OSTEOIMPLANTS

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Cell permeable structural implant

Polyurethanes for osteoimplants

Bone matrix compositions and methods

Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

Osteoimplant and method for its manufacture

An osteoimplant comprises a solid aggregate of bone derived elements, adjacent bone-derived elements being bonded to each other through chemical linkages between their adjacent surface-exposed collagen. Various other components can be incorporated into the bone implant material such as bone-growth inducing substances.

Bone-derived implant for load-supporting applications

Delivery system attachment

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Process for selecting bone for transplantation

A procedure for determining a plan for cutting a bone sample for use as an implant provides scanning the bone with a CT scanning system to provide slice images of the bone. The scanning system then determines the cortical or cancellous bone dimensions and density of the bone. Determining such dimensions and density permits accurate planning and preparation of an implant graft that is correlated to the predetermined plan without waste of bone through cutting test specimens to determine the bone parameters. Other images techniques that provide slice images are also disclosed.

Implant for orthopedic applications

Bone-derived implant for load-supporting applications

Segmentally demineralized bone implant and method for its manufacture

IMPLANT, METHOD OF MAKING THE SAME AND USE THEREOF FOR THE TREATING OF BONES DEFECTS

Polyurethanes for Osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Delivery system attachment

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Process for selecting bone for transplantation

Method of hard tissue repair

Spinal intervertebral implant, interconnections for such implant and processes for making

A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form the offsets and different configurations for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.

Synthesis of a bone-polymer composite material

Bone matrix compositions and methods

Injectable and moldable bone substitute materials

Osteogenic implants derived from bone

An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.

Osteoimplant and method for making same

A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

POLYURETHANES FOR OSTEOIMPLANTS

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

SPINAL INTERVERTEBRAL IMPLANT, INTERCONNECTIONS FOR SUCH IMPLANT AND PROCESSES FOR MAKING

SYNTHESIS OF A BONE-POLYMER COMPOSITE MATERIAL

Method of treating bone for implantation and resulting bone

Synthesis of a bone-polymer composite material

P:\OPER\MAU20l9U0799999 Div.doc-19n /ZO19 A method of producing a bone-polymer composite. The method comprises the steps of 5 providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

Polyurethanes for osteoimplants

Polyurethanes for osteoimplants

The invention relates to biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine 5 diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Delivery system attachment

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Non-destructive method for evaluating the strength of cancellous bone

A non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following tests on each cancellous bone of a population of cancellous bones: a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and, eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.

OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents. 172-. (canceled)73. An osteoinductive composition comprising:at least partially demineralized cancellous bone, the at least partially demineralized cancellous bone having been treated to increase the osteoinductive activity of the bone;wherein the at least partially demineralized cancellous bone exhibits increased osteoinductive activity when compared to untreated at least partially demineralized cancellous bone.74. The osteoinductive composition of claim 73 , wherein the composition has a histologic osteoinductivity score of at least 1 on a 4 point scale.75. The osteoinductive composition of claim 73 , wherein the composition induces bone formation in higher order species.76. The osteoinductive composition of claim 73 , wherein the composition exhibits a solid structure at room temperature and substantially liquefies when implanted in a body.77. The osteoinductive composition of claim 73 , wherein the composition has ...

IMPLANTAT FÜR ORTHOPÄDISCHE ANWENDUNGEN

SEGMENTED DELIVERY SYSTEM

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

Biocompatible osteogenic band for repair of spinal disorders

Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.

Shaped load-bearing osteoimplant and methods of making same

A load-bearing osteoimplant, methods of making the osteoimplant and method for repairing hard tissue such as bone and teeth employing the osteoimplant are provided. The osteoimplant comprises a shaped, coherent mass of bone particles which may exhibit osteogenic properties. In addition, the osteoimplant may possess one or more optional components which modify its mechanical and/or bioactive properties, e.g., binders, fillers, reinforcing components, etc.

Methods of making shaped load-bearing osteoimplant

A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles.

Process for selecting bone for transplantation

A procedure for determining a plan for cutting a bone sample for use as an implant provides scanning the bone with a CT scanning system to provide slice images of the bone. The scanning system then determines the cortical or cancellous bone dimensions and density of the bone. Determining such dimensions and density permits accurate planning and preparation of an implant graft that is correlated to the predetermined plan without waste of bone through cutting test specimens to determine the bone parameters. Other images techniques that provide slice images are also disclosed.

DELIVERY SYSTEM

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Load bearing osteoimplant and method of repairing bone using the same

A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.

OSTEOIMPLANTAT UND METHODE ZU SEINER HERSTELLUNG

Non-destructive method for evaluating the strength of cancellous bone

A non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following tests on each cancellous bone of a population of cancellous bones: a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and, eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.

DELIVERY SYSTEM ATTACHMENT

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Synthesis of a bone-polymer composite material

A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

Osteoinductive demineralized cancellous bone

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also ...

Segmented delivery system

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

Segmented delivery system

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

Ramp-shaped intervertebral implant

A ramp-shaped intervertebral implant is disclosed. The implant has a body having a first end, a second end, a top surface and a bottom surface. At least one of the top and bottom surfaces is tapered and converges towards the second end of the body. An opening extends through the body and has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

DELIVERY SYSTEMS, TOOLS, AND METHODS OF USE

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.

INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS

An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

Delivery system

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Osteogenic implants derived from bone

An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.

Osteoimplant and Method for Making Same

A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

SHAPED LOAD-BEARING OSTEOIMPLANT AND METHODS OF MAKING THE SAME

A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles. 128-. (canceled)29. An integral implant insertion instrument and implant comprising an implant insertion instrument porting integrally attached to an implant portion by a weakened , break-away connection such that on insertion of the implant portion at the implantation site , the implant insertion instrument portion is separated from the implant portion by a breaking-away force applied thereto , the implant portion being a load-bearing osteoimplant comprising a shaped , coherent mass of bone particles.30. The integral implant insertion instrument and implant of in which the load-bearing osteoimplant portion contains at least one additional component selected from the group consisting of binder claim 29 , filler claim 29 , plasticizer claim 29 , wetting agent claim 29 , surface active agent claim 29 , biostatic/biocidal agent claim 29 , bioactive substance claim 29 , reinforcing material claim 29 , reinforcing structure or combinations thereof.31. The integral implant insertion instrument and implant of in which the binder present in the load-bearing osteoimplant is a natural claim 30 , synthetic or semisynthetic bioresorbable or nonbioresorbable polymer.3244-. (canceled) This application is a continuation-in-part of U.S. patent application Ser. No. 10/229,767, filed Aug. 27, 2002, which is a continuation-in-part of commonly assigned copending U.S. patent application Ser. No. 09/911,562, filed Jul. 24, 2001 as a continuation of U.S. patent application Ser. No. 09/256,447, filed Feb. 23, 1999, now U.S. Pat. No. 6,294,187.This invention relates to osteoimplants and their use in the repair of bone defects and injuries. More particularly, the invention relates to a load-bearing composite osteoimplant which can assume any of a wide variety of configurations, methods for their manufacture and the use of the osteoimplants for the repair of hard tissue.Shaped or cut bone segments have ...

DELIVERY SYSTEM CARTRIDGE

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. In some embodiments, the covering may be configured and sized for receipt by an implant device. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance.

OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also ...

Ramp-shaped intervertebral implant

A ramp-shaped intervertebral implant is disclosed. The implant has a body having a first end, a second end, a top surface and a bottom surface. At least one of the top and bottom surfaces is tapered and converges towards the second end of the body. An opening extends through the body and has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

METHODS AND DEVICES FOR DELIVERING THERAPEUTIC MATERIALS TO THE INTERVERTEBRAL DISC

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided. 1. A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc , the method comprising inserting a delivery tool containing the therapeutic agent through an anterior portion , a lateral portion , or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc.2. The method of claim 1 , wherein the method comprises forming an entry point of delivery with a surgical tool between an endplate and an annular body before inserting the delivery tool claim 1 , and inserting the delivery tool through the anterior portion or the lateral portion.3. The method of claim 1 , wherein the method comprises forming a posterior entry point of delivery with a surgical tool claim 1 , and inserting the delivery tool is done from a lateral or anterolateral portion.4. The method of claim 2 , wherein the surgical tool is a drill.5. A device for delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc claim 2 , the device comprising a cannula configured to slidably receive the therapeutic agent and a needle claim 2 , the cannula having a distal end claim 2 , the distal end configured to penetrate through an anterior portion claim 2 , a lateral portion claim 2 , a posterior portion or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc claim 2 , the needle configured to slide in at least a portion of ...

Biocompatible osteogenic band for repair of spinal disorders

Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.

DELIVERY SYSTEM

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization

A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.

Processes for making spinal intervertebral implant, interconnections for such implant

A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form offset configurations in place of the offset bores for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.

Osteoimplant and method for making same

A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

Osteoimplant

An osteoimplant comprises a solid aggregate of bone derived elements, adjacent bone-derived elements being bonded to each other through chemical linkages between their adjacent surface-exposed collagen. Various other components can be incorporated into the bone implant material such as bone-growth inducing substances.

Implant for orthopedic applications

An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Delivery system cartridge

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. In some embodiments, the covering may be configured and sized for receipt by an implant device. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance.

Kemikten türetilmiş osteojenik implantlar

Method of hard tissue repair

A method for promoting the growth of bone, periodontium, or ligament in a warm-blooded vertebrate, the method comprising: producing a surgical flap to expose the bone, periodontium or ligament; debriding the bone, periodontium or ligament to remove organic matter from the bone, periodontium or ligament; implanting an effective amount of an osteogenic bone graft material, the bone graft material consisting of an osteoimplant having not greater than about 32% void volume formed at least in part from elongate bone-derived elements optionally in combination with bone powder; replacing the flap; and, allowing the bone, periodontium or ligament to regrow.

Yük taşıyan osteoemplant üretim yöntemi.

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

SEGMENTED DELIVERY SYSTEM

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses. 114.-. (canceled)15. A tool for grasping and placing a delivery system near a bone comprising: a handle connected to a docking port , said docking port configured to attached to a rigid structure attached to a bone repair delivery system; and a plunger disposed in said handle configured to push and release said rigid structure into a bone location.16. A tool of claim 15 , wherein the bone repair delivery system comprises a plurality of operably linked segments of at least two types: a first segment type comprising a covering material defining at least one compartment configured to retain a bone growth substance; and a second segment type configured to connect segments of the first type; said delivery system configured to retain a bone growth substance.17. A tool of claim 16 , wherein the bone repair delivery system comprises segments of the first type that vary in size.18. A tool of claim 16 , wherein the second segment type is comprised of a covering material.19. A tool of claim 16 , wherein the segments of the first type are pre-filled with approximately equivalent amounts of bone growth substance.20. A tool of claim 16 , wherein the second type segments are configured to retain little or no bone growth ...

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm 3 and a wet compressive strength of at least about 3 MPa.

Bone-derived implant for load-supporting applications

A bone-derived implant is provided which is made up of one or more layers of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers of some other material. The layers constituting the implant are assembled into a unitary structure to provide an implant exhibiting good overall load-supporting properties.

Delivery system

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Delivery systems, tools, and methods of use

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.

Implant, method of making the same and use thereof for the treating of bones defects

An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.

Ramp-shaped intervertebral implant

A ramp-shaped intervertebral implant (10) is disclosed. The implant has a body having a first end (16), a second end (14), a top surface (22) and a bottom surface (24). At least one of the top and bottom surfaces is tapered that converges towards the second end of the body. An opening (26) extends through the body, has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

Synthesis of a bone-polymer composite material

A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

Spinal intervertebral implant, interconnections for such implant and processes for making

A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form the offsets and different configurations for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.

Multiple component osteoimplant

The present invention is an osteoimplant that comprises two or more portions, wherein two or more of the portions are self-interlockable with one another to form the desired osteoimplant. The components of the osteoimplant may be of the same material or of different materials. Suitable materials may include cortical bone, cancellous bone, structural polymer, other biomaterial, or any combination thereof.

Osteoimplant and method for its manufacture

The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into the bone implant material such as bone-growth inducing substances; and a method of manufacture.

Osteoimplant and method for its manufacture

The invention relates to an osteoimplant fabricated from a solid aggregate of bone-derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into the bone implant material such as bone-growth inducing substances; and a method of manufacture.

Spinal intervertebral implant, interconnections for such implant and processes for making

A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form the offsets and different configurations for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.

SURFACES ENTMINERALIZED EASTERN OIL PLANTATE AND METHOD FOR THE PRODUCTION THEREOF

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Ramp-shaped intervertebral implant

A ramp-shaped intervertebral implant (10) is disclosed. The implant has a body having a first end (16), a second end (14), a top surface (22) and a bottom surface (24). At least one of the top and bottom surfaces is tapered that converges towards the second end of the body. An opening (26) extends through the body, has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

Lyophilized monolithic bone implant and method for treating bone

Monolithic bone intended for implantation is treated in order to conserve its mechanical strength during lyophilization and subsequent packaging and to maintain the strength of the bone during the storage period preceding the rehydration and implantation of the bone. The method of treatment comprises contacting the bone with a mechanical strength-conserving amount of at least one biocompatible mechanical strength-conserving agent, the agent being a liquid organic material which is capable of penetrating and remaining in the bone during its lyophilization, packaging and storage, lyophilizing the bone containing the mechanical strength-conserving agent and packaging the lyophilized bone.

Implant, method of making the same and use thereof for the treating of bone defects

An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.

Synthesis of a bone-polymer composite material

Synthesis of a Bone-Polymer Composite Material A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

Method for dehydrating bone for implantation

A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.

Method for dehydrating bone for implantation

A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.

Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.

Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.

Delivery system attachment

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Multiple component osteoimplant

The present invention is an osteoimplant that comprises two or more portions, wherein two or more of the portions are self-interlockable with one another to form the desired osteoimplant. The components of the osteoimplant may be of the same material or of different materials. Suitable materials may include cortical bone, cancellous bone, structural polymer, other biomaterial, or any combination thereof.

Bone-derived implant for load-supporting applications

A bone-derived implant (20) is provided which is made up of one or more layers (22, 23) of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers (22, 23) of some other material. The layers (22, 23) constituting the implant (20) are assembled into a unitary structure to provide an implant (20) exhibiting good overall load-supporting properties.

Osteoimplant and method for its manufacture

The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into the bone implant material such as bone-growth inducing substances; and a method of manufacture.

Methods and devices for delivering therapeutic materials to the intervertebral disc

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Methods and devices for delivering therapeutic materials to the intervertebral disc

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Method of treating and dehydrating bone for implantation

Monolithic bone intended for implantation is treated in oder to conserve its mechanical strength during dehydration and subsequent packaging and to maintain the strength of the bone during the storage period preceding the rehydration and implantation of the bone. The method of treatment comprises contacting the bone with a mechanical strength-conserving amount of at least one biocompatible mechanical strength-conserving agent, the agent being a liquid organic material which is capable of penetrating and remaining in the bone during its dehydration, packaging and storage, dehydrating the bone containing the mechanical strength-conserving agent and packaging the dehydrated bone.

Methods and devices for delivering therapeutic materials to the intervertebral disc

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Methods and devices for delivering therapeutic materials to the intervertebral disc

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Methods and devices for delivering therapeutic materials to the intervertebral disc

Cell permeable structural implant

An implant including a cell conducting phase and a binder phase. At least a portion of the surface of the implant includes the cell conducting phase, and the cell conducting phase defines a path from the surface of the implant to an interior of the implant.

Cell permeable structural implant comprising conducting phase and binder phase

Disclosed is an implant comprising a cell conducting phase and a binder phase, the binder phase and cell conducting phase being present in proportions such that the cell conducting phase provides a continuous path for cell migration and tissue in-growth across the composite, wherein the cell conducting phase comprises one or more of a tissue-derived material, an extracellular matrix component, a synthetic extracellular matrix analog, a polymer and a ceramic material.

Cell permeable structural implant

An implant including a cell conducting phase and a binder phase. At least a portion of the surface of the implant includes the cell conducting phase, and the cell conducting phase defines a path from the surface of the implant to an interior of the implant.

Method for dehydrating bone for implantation

A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.

Polyurethanes for osteoimplants

biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Polyurethanes for osteoimplants

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Delivery system attachment

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.