05-11-2015 дата публикации
Номер: US20150314259A1
Принадлежит:
Illumina, Inc
Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers. 118-. (canceled)19. A chemical reaction processing system comprising:a substrate comprising a plurality of depressions and a porous material comprising a plurality of reaction sites, said porous material fixed in at least some of the depressions of said plurality of depressions; andone or more dispensing stations configured to dispense a liquid reagent into said at least some of the depressions.2023-. (canceled)24. The system of claim 19 , wherein each of said one or more dispensing stations comprises a plurality of nozzles.25. The system of claim 19 , wherein the porous material has a surface area to volume ratio greater than five.26. The system of further comprising a sensor for detecting the presence of a depression at a dispensing station.27. The system of claim 26 , wherein the sensor activates dispensing from the dispensing station when a leading edge of a depression engages the sensor.28. The system of claim 26 , wherein the sensor deactivates dispensing from the dispensing station when a trailing edge of a depression engages the sensor.29. The system of further comprising a reagent removal system.30. The system of claim 29 , wherein the reagent removal system comprises an inlet that produces a stream of gas capable of extracting reagent from the porous material.31. The system of claim 29 , wherein the reagent removal system comprises an outlet that produces a vacuum that is capable of extracting reagent from the porous material.32. The system of further comprising a control system that coordinates reagent dispensing and reagent removal.33. The system of claim 19 , wherein the one or more dispensing stations dispense reagents selected from a deblock reagent claim 19 , a monomer reagent claim 19 , an oxidizing reagent claim 19 , a capping reagent and a wash reagent.34. The system of claim 19 , wherein the substrate comprises a ...
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