18-06-2015 дата публикации
Номер: US20150166503A1
Принадлежит:
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used. 2. The compound of claim 1 , wherein Ris Pand Ris H.3. The compound of claim 1 , wherein Ris H and Ris P.4. The compound of claim 1 , wherein Ris Pand Ris P.615-. (canceled)16. The compound of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare H claim 1 , or wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare deuterium.17. (canceled)18. The compound of claim 1 , wherein Z is —OR claim 1 , —N(R)R claim 1 , or P.19. (canceled)20. The compound of claim 1 , wherein Z is —OH claim 1 , —OR claim 1 , —N(R)R claim 1 , or P.21. (canceled)22. The compound of claim 1 , wherein Z is not —OH and Ris not unsubstituted or substituted benzyl.25. The compound of claim 24 , wherein Z is —OR.26. The compound of claim 24 , wherein Z is —N(R)R.27. The compound of claim 24 , wherein Z is —SR.28. The compound of claim 24 , wherein Z is P.29. The compound of claim 24 , wherein Z is ORand Ris bicycloalkyl claim 24 , alkylcycloalkyl claim 24 , or alkylcycloheteroalkyl.30. The compound of claim 24 , wherein Ris haloalkyl.31. (canceled)32. The compound of claim 24 , wherein Ris hydrogen and Ris P.33. The compound of claim 24 , wherein Ris Pand Ris hydrogen.34. The compound of claim 24 , wherein Ris Pand Ris P.35. The compound of claim 24 , wherein Rand Rare each hydrogen.36. A compound according to claim ...
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