Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 7. Отображено 6.
28-07-2016 дата публикации

COHESIVE MATERIALS INCLUDING DERIVATIZED COLLAGENS AND METHODS OF MAKING AND USING THEM

Номер: US20160213814A1
Автор: Laurence J. Berlowitz, Hans P.I. Claesson, Matthew Fullana, Gary E. Wnek, BERLOWITZ LAURENCE J, CLAESSON HANS P I, FULLANA MATTHEW, WNEK GARY E, Berlowitz Laurence J., Claesson Hans P.I., Fullana Matthew, Wnek Gary E.
Принадлежит: Individual

Certain embodiments described herein are directed to cohesive materials comprising treated, derivatized collagen molecules. In some embodiments, the cohesive material can function as a putty or defect filler that can be used in a tissue repair. Methods of using the cohesive materials are also described.

Подробнее
Номер записи: 1
03-01-2019 дата публикации

COLLAGEN BASED MATERIALS AND METHODS OF USING THEM

Номер: US20190001020A1
Автор: Berlowitz Laurence J., Claesson Hans P.I., Fullana Matthew, Wnek Gary E.
Принадлежит:

Certain configurations of adhesive materials are described which comprise a crosslinked derivatized atelocollagen. In some configurations, the crosslinked, derivatized atelocollagen is cured to provide a burst strength of at least 55 kPa or 60 kPa (or more) as tested by ASTM F2392-04. In some instances, the crosslinked derivatized atelocollagen comprises a methylated atelocollagen that is crosslinked using one or more functionalized crosslinking agents. 1100-. (canceled)101. A method of repairing a tissue defect comprising:disposing a composition at a defect site of the tissue, the composition comprising a derivatized atelocollagen comprising a number average molecular weight of less than or equal to 300 kDa, a first crosslinking agent and a second crosslinking agent different than the first crosslinking agent;adding a curing agent to the disposed composition; andpermitting the curing agent to remain on a surface of the disposed composition for a curing period.102. The method of claim 101 , further comprising rinsing any excess curing agent from the disposed composition after the curing period.103. The method of claim 101 , further comprising adding the curing agent as a solid to the disposed composition.104. The method of claim 101 , further comprising adding the curing agent as a liquid to the disposed composition.105. The method of claim 101 , further comprising configuring the derivatized atelocollagen as methylated atelocollagen.106. The method of claim 105 , configuring one of the first and second crosslinking agents to comprise a succinimidyl group.107. The method of claim 105 , configuring one of the first and second crosslinking agents to comprise a sulfhydryl group.108. The method of claim 101 , further comprising configuring the composition to comprise an acidic pH.109. The method of claim 101 , further comprising layering the composition over the defect site prior to curing the composition.110. The method of claim 101 , further comprising configuring the ...

Подробнее
Номер записи: 2
25-01-2018 дата публикации

ADHESIVE MATERIALS AND SEQUESTERED CURING AGENTS USED TO PRODUCE THEM

Номер: US20180021237A1
Автор: Berlowitz Laurence J, Claesson Hans P.I., Fullana Matthew, Wnek Gary E
Принадлежит:

Certain configurations of adhesive materials are described which comprise a crosslinked derivatized atelocollagen that can be cured with a sequestered curing agent. In some configurations, the crosslinked, derivatized atelocollagen is used to provide an adhesive that can be used to hold two or more tissues to each other for some period and permit a tissue repair process to occur. 1. An adhesive material comprising a crosslinked , derivatized atelocollagen and a sequestered curing agent.2. The adhesive material of claim 1 , in which the derivatized atelocollagen is an alkylated mammalian atelocollagen or a methylated atelocollagen claim 1 , in which the alkylated or methylated derivatized atelocollagen comprises:a number average molecular weight of about 300 kDa; ora number average molecular weight of about 300 kDa to about 600 kDa; ora number average molecular weight of less than 300 kDa.3. The adhesive material of claim 1 , in which the sequestered curing agent is a solid curing agent.4. The adhesive material of claim 1 , in which the crosslinked claim 1 , derivatized atelocollagen is crosslinked with a polyethylene glycol crosslinking agent.5. The adhesive material of claim 4 , in which the polyethylene cros slinking agent comprises at least one of a succinimidyl group claim 4 , a sulfhydryl group or an amino group.6. The adhesive material of claim 4 , in which the polyethylene glycol cros slinking agent comprises a first crosslinking agent comprising at least one electrophilic group and a second crosslinking agent comprising at least one nucleophilic group.7. The adhesive material of claim 1 , in which the crosslinked claim 1 , derivatized atelocollagen is cured at a curing time of more than 10 minutes to provide the adhesive material.8. The adhesive material of claim 1 , in which the derivatized atelocollagen is methylated mammalian atelocollagen claim 1 , in which a first crosslinking agent comprises the formula of and a second crosslinking agent comprises the ...

Подробнее
Номер записи: 3
30-03-2017 дата публикации

COLLAGEN BASED MATERIALS AND METHODS OF USING THEM

Номер: US20170087272A1
Автор: Berlowitz Laurence J, Claesson Hans P.I., Fullana Matthew, Wnek Gary E
Принадлежит:

Certain configurations of adhesive materials are described which comprise a crosslinked derivatized atelocollagen. In some configurations, the crosslinked, derivatized atelocollagen is cured to provide a burst strength of at least 55 kPa or 60 kPa (or more) as tested by ASTM F2392-04. In some instances, the crosslinked derivatized atelocollagen comprises a methylated atelocollagen that is crosslinked using one or more functionalized crosslinking agents. 1. An adhesive/sealant material comprising a crosslinked , derivatized atelocollagen that provides a burst strength of about 60 kPa or more after curing as tested by ASTM F2392-04.2. The adhesive/sealant material of claim 1 , in which the derivatized atelocollagen is an alkylated mammalian atelocollagen or a methylated atelocollagen claim 1 , in which the alkylated or methylated derivatized atelocollagen comprises:a number average molecular weight of about 300 kDa; ora number average molecular weight of about 300 kDa to about 600 kDa; ora number average molecular weight of less than 300 kDa.3. The adhesive/sealant material of claim 1 , in which the crosslinked claim 1 , derivatized atelocollagen is cured with a solid curing agent to provide the burst strength of about 60 kPa or more after curing as tested by ASTM F2392-04.4. The adhesive/sealant material of claim 1 , in which the crosslinked claim 1 , derivatized atelocollagen is crosslinked with a polyethylene glycol crosslinking agent.5. The adhesive/sealant material of claim 4 , in which the polyethylene crosslinking agent comprises at least one of a succinimidyl group claim 4 , a sulfhydryl group or an amino group.6. The adhesive/sealant material of claim 4 , in which the polyethylene glycol crosslinking agent comprises a first crosslinking agent comprising at least one electrophilic group and a second crosslinking agent comprising at least one nucleophilic group.7. The adhesive/sealant material of claim 1 , in which the crosslinked claim 1 , derivatized ...

Подробнее
Номер записи: 4
03-10-2002 дата публикации

Composition and methods for the production of biological tissues and tissue constructs

Номер: CA2441994A1
Автор: Laurence J. Berlowitz Tarrant, Shuichi Mizuno, Toshimasa Tokuno
Принадлежит: Individual

The present invention relates to compositions and methods for preparing tissues or tissue constructs. In selected embodiments, the invention relates to the construction of a multi-layered biological structure (i.e. system) th at includes a cellular support matrix seeded with living cells derived from a native tissue. The present invention also relates to tissue culture protocol s to promote the in vitro growth of tissues and tissue constructs.

Подробнее
Номер записи: 5
20-03-2018 дата публикации

Cohesive materials including derivatized collagens and methods of making and using them

Номер: US09919075B2
Автор: Gary E Wnek, Hans P. I. Claesson, Laurence J Berlowitz, Matthew FULLANA
Принадлежит: Anexis LLC

Certain embodiments described herein are directed to cohesive materials comprising treated, derivatized collagen molecules. In some embodiments, the cohesive material can function as a putty or defect filler that can be used in a tissue repair. Methods of using the cohesive materials are also described.

Подробнее
Номер записи: 6