29-10-2015 дата публикации
Номер: US20150306232A1
Принадлежит:
Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. Also described herein are oligopeptides compounds made from D-amino acid residues that form supramolecular hydrogels. The compounds may be functionalized with active agents, such as anticancer therapeutic agents, antiinflammatory agents, or imaging agents, therefore providing new mechanisms for delivery of active agents. 3. (canceled)4. The hydrogelator of claim 1 , wherein R is H.5. The hydrogelator of claim 1 , wherein Ris aralkyl or heteroaralkyl.6. (canceled)7. The hydrogelator of claim 5 , wherein Ris benzyl.8. The hydrogelator of claim 1 , wherein Ris aralkyl claim 1 , hydroxyaralkyl claim 1 , phosphorylated aralkyl claim 1 , alkyl claim 1 , aminoalkyl claim 1 , or hydroxyalkyl.9. (canceled)10. The hydrogelator of claim 8 , wherein Ris hydroxybenzyl.11. (canceled)12. The hydrogelator of claim 8 , wherein Ris phosphorylated benzyl.13. (canceled)14. The hydrogelator of claim 8 , wherein Ris aminobutyl.15. The hydrogelator of claim 1 , wherein n is 1 claim 1 , 2 claim 1 , or 3.16. (canceled)17. The hydrogelator of claim 1 , wherein m is 0 claim 1 , 1 claim 1 , or 2.1819-. (canceled)20. The hydrogelator of claim 1 , wherein each amino acid residue is in the D-configuration.23. (canceled)24. The hydrogelator of claim 21 , wherein R is H.25. The hydrogelator of claim 21 , wherein Ris aralkyl or heteroaralkyl.26. (canceled)27. The hydrogelator of claim 25 , wherein Ris benzyl.28. The hydrogelator of claim 21 , wherein n is 1 claim 21 , 2 claim 21 , or 3.29. (canceled)30. The hydrogelator of claim 21 , wherein Ris A-NR-alkyl.3132-. (canceled)33. The hydrogelator of claim 30 , wherein Ris A-NH-butyl.34. The hydrogelator of claim 21 , wherein p is 1 claim 21 , 2 claim 21 , or 3.3536-. (canceled)37. The hydrogelator of claim ...
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