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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 34. Отображено 32.
28-02-2013 дата публикации

AIR CLEANER WITH AN ELECTRICAL CURRENT IN A CORONA WIRE CORRELATING TO AIR SPEED

Номер: US20130047857A1
Автор: Bohlen John R.
Принадлежит:

An air cleaner including a corona wire assembly, a power supply electrically connected to the corona wire assembly, a fan to draw air through the air cleaner, a fan speed control, and a controller to sense the fan speed and control the power supply, such that an amplitude of a current provided by the power supply to the corona wire assembly is proportional to the fan speed is described. By varying the corona wire assembly current proportionally with the fan speed, the ozone output is minimized at all speeds. So as fan speed decreases, the current supplied to a corona wire assembly decreases, thereby reducing the ozone generated by the air cleaner. 1. An air cleaner comprising:a corona wire assembly;a power supply electrically connected to the corona wire assembly;a fan to draw air through the air cleaner;a fan speed control; anda controller to sense the fan speed and control the power supply, such that an amplitude of a current provided by the power supply to the corona wire assembly is proportional to the fan speed.2. The air cleaner of claim 1 , wherein the fan speed control comprises a continuous fan speed control.3. The air cleaner of claim 1 , wherein the fan speed control comprises a discrete fan speed control.4. The air cleaner of claim 1 , wherein the controller comprises a Pulse Width Modulation (PWM) circuit whose duty cycle controls the power supply.5. The air cleaner of claim 1 , wherein the controller steps the voltage provided to the power supply.6. The air cleaner of claim 1 , further comprising a collection assembly disposed downstream of the corona assembly.7. The air cleaner of claim 1 , wherein the corona assembly comprises corona ground elements.8. The air cleaner of claim 1 , wherein the fan comprises an axial fan.9. The air cleaner of claim 1 , wherein the fan comprises a centrifugal fan.10. The air cleaner of claim 1 , wherein ozone produced by the corona wire assembly is reduced when an electrical current through the corona wire assembly is ...

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28-02-2013 дата публикации

Electrostatic precipitator with collection charge plates divided into electrically isolated banks

Номер: US20130047858A1
Принадлежит: Oreck Holdings LLC

An electrostatic precipitator cell containing a collection assembly, a plurality of collection assembly ground plates disposed in the collection assembly, a plurality of banks disposed in the collection assembly, wherein each bank containing a collection assembly charge plate and a voltage isolator is described. Electrically isolating portions of an electrostatic precipitator cell results in reduced arcing and overall increases in cleaning efficiency. As air cleaner utilizing the electrostatic precipitator with isolated banks is also described.

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28-02-2013 дата публикации

Electrostatic precipitator cell with removable corona unit

Номер: US20130047859A1
Автор: John R. Bohlen
Принадлежит: Oreck Holdings LLC

A corona wire assembly including a first supporting member including a retaining device; a second supporting member including a retaining device; a corona wire capable of carrying a high voltage disposed between the first supporting member and the second supporting member; a ground discharge electrode disposed between the first supporting member and the second supporting member; wherein the corona assembly is separately installed and removed from an electrostatic precipitator is described. Current to the corona wire assembly can be tied to a fan assembly speed.

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28-02-2013 дата публикации

PHOTO-CATALYTIC AIR PURIFIER SYSTEM WITH ILLUMINATED ANGLED SUBSTRATE

Номер: US20130052090A1
Автор: Bohlen John R.
Принадлежит:

A photo-catalytic oxidizing (PCO) assembly including a PCO substrate including a first and second outer surface, and a plurality of air passages having a depth that extend between the first outer surface to the second outer surface at an angle that is not orthogonal to the first outer surface is described. A photo-catalyst is disposed on the substrate and stimulated using an ultra violet light source. An air cleaner using the PCO assembly is also described. 1. A photo-catalytic oxidizing (PCO) assembly comprising: a first outer surface,', 'a second outer surface,', 'a plurality of air passages having a depth that extend from the first outer surface to the second outer surface at an angle that is not orthogonal to the first outer surface, and', 'a photo-catalyst disposed on the substrate; and, 'a PCO substrate including'}an ultra-violet (UV) light source disposed to illuminate the second outer surface,2. The PCO assembly of claim 1 , wherein the angle and the depth of the air passages is sufficient to block illumination generated by the UV light source from being visible through the air passages.3. The PCO assembly of claim 1 , wherein the first outer surface is disposed opposite the second outer surface.4. The PCO assembly of claim 1 , wherein the air passages include sidewalls and the photo-catalyst is disposed on the sidewalls.5. The PCO assembly of claim 1 , wherein a cross-section of the air passages are substantially hexagonal.6. The PCO assembly of claim 1 , wherein a non-photo-catalyst is disposed on the first surface and a portion of the air passages extending therefrom.7. The PCO assembly of claim 1 , wherein the photo-catalyst is disposed on the second surface and a portion of the air passages extending therefrom.8. The PCO assembly of claim 1 , wherein the UV light source comprises a light emitting diode (LED).9. The PCO assembly of claim 1 , wherein the angle is substantially about 15°.10. The PCO assembly of claim 1 , a plurality of light sources ...

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06-02-2020 дата публикации

HANDHELD VACUUM CLEANER

Номер: US20200037835A1
Принадлежит:

A handheld vacuum cleaner including a fluid flow path, a main body, a fluid flow motor, a battery, and a cyclone chamber. The fluid flow path extends from a dirty air inlet to a clean air outlet, and the main body includes a handle. The fluid flow motor is positioned in the fluid flow path. The battery is positioned below the fluid flow motor. The cyclone chamber is in the fluid flow path transverse to the dirty air inlet. The cyclone chamber includes a first end wall and a second end wall, a cyclone chamber axis passing through the first end wall and the second end wall, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet. The first end wall and the second end wall of the cyclone chamber both intersect a common horizontal plane when the handheld vacuum cleaner is positioned on a horizontal surface. 1. A handheld vacuum cleaner comprising:a fluid flow path extending from a dirty air inlet to a clean air outlet;a main body including a handle;a fluid flow motor positioned in the fluid flow path;a battery positioned below the fluid flow motor; and a first end wall and a second end wall,', 'a cyclone chamber axis passing through the first end wall and the second end wall,', 'a cyclone dirty fluid inlet, and', 'a cyclone clean fluid outlet,', 'wherein the first end wall and the second end wall of the cyclone chamber both intersect a common horizontal plane when the handheld vacuum cleaner is positioned on a horizontal surface., 'a cyclone chamber in the fluid flow path transverse to the dirty air inlet, the cyclone chamber including'}2. The handheld vacuum cleaner of claim 1 , wherein the battery is a removable and rechargeable battery pack.3. The handheld vacuum cleaner of claim 1 , wherein the battery is entirely positioned below the fluid flow motor.4. The handheld vacuum cleaner of claim 1 , wherein the handheld vacuum cleaner is supported solely by the battery when the handheld vacuum cleaner is positioned on a horizontal surface.5. The handheld vacuum ...

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06-02-2020 дата публикации

HANDHELD VACUUM CLEANER

Номер: US20200037836A1
Принадлежит:

A handheld vacuum cleaner including a dirty air inlet, a fluid flow path, a main body, a fluid flow motor, a premotor filter, and a debris separator. The dirty air inlet is disposed at the front of the handheld vacuum cleaner and defines an inlet axis. The fluid flow path extends from the dirty air inlet to a clean air outlet. The main body includes a handle disposed at the rear of the handheld vacuum cleaner. The fluid flow motor is positioned in the main body along the fluid flow path and defines a motor axis. The premotor filter is disposed in the main body and includes an annular filter media forming a filter axis. The annular filter media includes a first end, a second end, and a longitudinal filter surface extending between the first end and second end. The annular filter media surrounds a filter air passageway along the filter axis and upstream of the fluid flow motor. The debris separator is upstream of the premotor filter in the fluid flow path and defines a debris separator axis. The filter axis is generally parallel to the motor axis. 1. A handheld vacuum cleaner comprising:a dirty air inlet disposed at the front of the handheld vacuum cleaner, the dirty air inlet defining an inlet axis;a fluid flow path extending from the dirty air inlet to a clean air outlet;a main body including a handle disposed at the rear of the handheld vacuum cleaner;a fluid flow motor positioned in the main body along the fluid flow path, the fluid flow motor defining a motor axis;a premotor filter disposed in the main body, the premotor filter including an annular filter media forming a filter axis, the annular filter media having a first end, a second end, and a longitudinal filter surface extending between the first end and second end, the annular filter media surrounding a filter air passageway along the filter axis, the filter air passageway upstream of the fluid flow motor, anda debris separator upstream of the premotor filter in the fluid flow path and defining a debris ...

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26-02-2015 дата публикации

Distress Signal for Notifying Potential Rescuers of Victims Trapped in a Structure

Номер: US20150054619A1
Принадлежит: HITBox Alarm Co LLC

A distress signaling system capable of withstanding natural disasters, manmade disasters, and other similar events comprising audible and visual signaling devices; a radio frequency receiver/transmitter system; powered by a rechargeable power source coupled with solar cells; and optionally a GPS emergency beacon, a two way communicator, a camera, and an cellular phone application activator; and an installation form enabling the consumer to quickly and easily install the system with no specialized tools or knowledge.

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16-07-2020 дата публикации

HANDHELD VACUUM CLEANER

Номер: US20200221910A1
Принадлежит:

A handheld vacuum cleaner including a fluid flow path, a main body including a handle, a fluid flow motor positioned in the fluid flow path, a dirt collection region, and a cyclone chamber in the fluid flow path. The cyclone chamber includes a first end wall, a second end wall, a sidewall extending along a cyclone axis, a cyclone dirt outlet formed in the sidewall, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet. A duct extends between the cyclone dirt outlet and the dirt collection region. The duct includes an upstream wall and a downstream flow-diverting wall forming a downstream boundary of the cyclone dirt outlet. The duct widens between the upstream wall and the downstream flow-diverting wall in a downstream direction away from the cyclone dirt outlet. 1. A vacuum cleaner comprising:a fluid flow path extending from a dirty air inlet to a clean air outlet;a main body including a handle;a fluid flow motor positioned in the fluid flow path;a dirt collection region; a first end wall, a second end wall, and a sidewall extending along a cyclone axis,', 'a cyclone dirt outlet formed in the sidewall,', 'a cyclone dirty fluid inlet, and', 'a cyclone clean fluid outlet; and, 'a cyclone chamber in the fluid flow path, the cyclone chamber including,'}a duct extending between the cyclone dirt outlet and the dirt collection region, the duct including an upstream wall and a downstream flow-diverting wall forming a downstream boundary of the cyclone dirt outlet, the downstream flow-diverting wall intersecting the fluid flow path adjacent the second end wall, wherein the duct widens between the upstream wall and the downstream flow-diverting wall in a downstream direction away from the cyclone dirt outlet.2. The vacuum cleaner of claim 1 , wherein the duct is arranged in a radial direction from the cyclone axis.3. The vacuum cleaner of claim 2 , wherein a radial line in the radial direction passes through the duct without intersecting the upstream wall or the ...

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09-12-2021 дата публикации

Disposal splash guard

Номер: US20210381212A1
Принадлежит: FB Global Plumbing Group LLC

The present invention provides a disposal splash guard that enables water flowing into the disposal splash guard to be directed through peripheral openings in the disposal splash guard. The disposal splash guard comprises a body and a baffle. A size of the peripheral openings is operable to direct water flowing into the disposal splash guard through the peripheral openings in the baffle. At least one of a shape of the body and a shape of the baffle is operable to direct water flowing into the disposal splash guard through the peripheral openings in the baffle. At least one of a size of the peripheral openings, a shape of the body, and a shape of the baffle is operable to direct at least ten percent of water flowing into the disposal splash guard through the peripheral openings in the baffle.

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22-11-2018 дата публикации

HANDHELD VACUUM CLEANER

Номер: US20180333021A1
Принадлежит: Techtronic Industries Co., Ltd.

A handheld vacuum cleaner includes a fluid flow path extending from a dirty air inlet to a clean air outlet, a main body including a handle, and a fluid flow motor positioned in the fluid flow path. The vacuum cleaner further includes a dirt collection region with an openable bottom and a cyclonic separator in the fluid flow-path. The cyclonic separator includes a cyclone chamber having a first end wall and a second end wall, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet. The vacuum cleaner further includes a filter chamber in the fluid flow path downstream from the cyclonic separator and upstream from the fluid flow motor. The filter chamber includes an outlet fluidiy communicating the filter chamber and the fluid flow motor and a tangential inlet fluidiy communicating the cyclonic separator and the filter chamber. 115.-. (canceled)16. A vacuum cleaner comprising:a fluid flow path extending from a dirty air inlet to a clean air outlet;a main body;a fluid flow motor positioned in the fluid flow path;a dirt collection chamber;a cyclonic separator in the fluid flow path, the cyclonic separator including a cyclone chamber having a first end and a second end, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet; anda filter chamber and a filter in the fluid flow path downstream from the cyclonic separator and upstream from the fluid flow motor;wherein the filter chamber includes an outlet fluidly communicating the filter chamber and the fluid flow motor and a tangential inlet fluidly communicating the cyclonic separator and the filter chamber.17. The vacuum cleaner of claim 16 , the filter including a cylindrical filter.18. The vacuum cleaner of claim 17 , wherein the fluid flow path extends through the cylindrical filter in a normal flow orientation.19. The vacuum cleaner of claim 17 , wherein the filter includes a first cylindrical filter and a second cylindrical filter claim 17 , the second cylindrical filter being nested within the first ...

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08-01-2020 дата публикации

Handheld vacuum cleaner

Номер: EP3373789B1
Принадлежит: Techtronic Industries Co Ltd

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03-08-2011 дата публикации

Air cleaner including constant current power supply

Номер: GB2452671B
Автор: John Relman Bohlen
Принадлежит: Oreck Holdings LLC

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02-11-2010 дата публикации

Air cleaner and shut-down method

Номер: CA2660020C
Принадлежит: Oreck Holdings LLC

An air cleaner (100) is provided according to an embodiment of the invention. The air cleaner (100) includes a high voltage power supply (108) configured to provide a high voltage to a collector cell (114) and a shut-down circuit (111) coupled to the high voltage power supply (108). The shut-down circuit (111) is configured to monitor an electrical current supplied to the collector cell (114), remove electrical power to the collector cell (114) if the electrical current exceeds a predetermined cell current threshold for a predetermined time period, and generate an indication if the electrical power is removed from the collector cell (114).

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28-02-2013 дата публикации

Air cleaner with an electrical current in a corona wire correlating to air speed

Номер: CA2784386A1
Автор: John R. Bohlen
Принадлежит: Oreck Holdings LLC

An air cleaner including a corona wire assembly, a power supply electrically connected to the corona wire assembly, a fan to draw air through the air cleaner, a fan speed control, and a controller to sense the fan speed and control the power supply, such that an amplitude of a current provided by the power supply to the corona wire assembly is proportional to the fan speed is described. By varying the corona wire assembly current proportionally with the fan speed, the ozone output is minimized at all speeds. So as fan speed decreases, the current supplied to a corona wire assembly decreases, thereby reducing the ozone generated by the air cleaner.

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14-12-2006 дата публикации

Carbon filter panel for an air cleaner

Номер: CA2611535A1
Автор: John R. Bohlen
Принадлежит: John R. Bohlen, Oreck Holdings, Llc

A carbon filter panel (100) for an air cleaner is provided according to an embodiment of the invention. The carbon filter panel (100) includes a frame (102) including one or more side members and a frame interior space and a plurality of spaced-apart carbon elements (108) extending across the frame interior space. Airflow can pass between the plurality of carbon elements (108) and through the carbon filter panel (100).

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28-02-2013 дата публикации

Electrostatic precipitator cell with removable corona unit

Номер: CA2783866A1
Автор: John R. Bohlen
Принадлежит: Oreck Holdings LLC

A corona wire assembly including a first supporting member including a retaining device; a second supporting member including a retaining device; a corona wire capable of carrying a high voltage disposed between the first supporting member and the second supporting member; a ground discharge electrode disposed between the first supporting member and the second supporting member; wherein the corona assembly is separately installed and removed from an electrostatic precipitator is described. Current to the corona wire assembly can be tied to a fan assembly speed.

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09-07-2007 дата публикации

Tower ionizer air cleaner.

Номер: MX2007007353A
Принадлежит: Oreck Holdings LLC

Se proporciona una torre (100) ionizadora limpiadora de aire. La torre (100) ionizadora limpiadora de aire incluye un chasis (101) de torre con una base del chasis (101) de torre que incluye un area de contacto pequena, una o mas aberturas (104) de admision de flujo de aire en el chasis (101) de torre, una o mas aberturas (110) de salida de flujo de aire en el chasis (101) de torre y sustancialmente opuestas a una o mas de las aberturas (104) de admision de flujo de aire y un elemento (102) ionizador colocado dentro del chasis (101) de torre. La torre (100) ionizadora limpiadora de aire incluye ademas dos o mas unidades (103) de ventilador que se localizan dentro de la torre (100) ionizadora limpiadora de aire y fijos al chasis (101) de torre. Las dos o mas unidades (103) de ventilador estan configuradas para proporcionar un flujo de aire entre una o mas aberturas (104) de admision de flujo de aire y una o mas de las aberturas (110) de salida de flujo de aire y a traves de un elemento (102) ionizador.

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10-01-2008 дата публикации

Air cleaner including an improved airflow path

Номер: WO2008005746A2
Автор: John R. Bohlen
Принадлежит: Oreck Holdings, Llc

An air cleaner (100) including an improved airflow path is provided according to the invention. The air cleaner (100) includes a duct (102) extending between an air inlet (105) of the air cleaner (100) and an air outlet (106), with the duct (102) being configured to conduct (102) an airflow. The duct (102) includes a shaped input region (122) located downstream of one or more air cleaning components and upstream of an impeller (107), a curved transition region (123) downstream of the shaped input region (122), with the curved transition region (123) transitioning the airflow from an air inlet (105) orientation to an air outlet (106) orientation, and an expansion output region (124) downstream of the curved transition region (123), with the expansion output region (124) allowing the airflow to expand. The air cleaner (100) further includes the impeller (107) located in the curved transition region (123) of the air duct (102). The airflow is smoothly conducted from the air inlet (105) to the air outlet (106) by the duct (102).

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18-05-2017 дата публикации

Handheld vacuum cleaner

Номер: WO2017083497A1
Принадлежит: Techtronic Industries Co. Ltd.

A handheld vacuum cleaner includes a fluid flow path extending from a dirty air inlet to a clean air outlet, a main body including a handle, and a fluid flow motor positioned in the fluid flow path. The vacuum cleaner further includes a dirt collection region with an openable bottom and a cyclonic separator in the fluid flow- path. The cyclonic separator includes a cyclone chamber having a first end wall and a second end wall, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet. The vacuum cleaner further includes a filter chamber in the fluid flow path downstream from the cyclonic separator and upstream from the fluid flow motor. The filter chamber includes an outlet fluidiy communicating the filter chamber and the fluid flow motor and a tangential inlet fluidiy communicating the cyclonic separator and the filter chamber.

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29-09-2020 дата публикации

Handheld vacuum cleaner

Номер: US10786126B2
Принадлежит: Techtronic Industries Co Ltd

A handheld vacuum cleaner includes a fluid flow path extending from a dirty air inlet to a clean air outlet, a main body including a handle, and a fluid flow motor positioned in the fluid flow path. The vacuum cleaner further includes a dirt collection region with an openable bottom and a cyclonic separator in the fluid flow-path. The cyclonic separator includes a cyclone chamber having a first end wall and a second end wall, a cyclone dirty fluid inlet, and a cyclone clean fluid outlet. The vacuum cleaner further includes a filter chamber in the fluid flow path downstream from the cyclonic separator and upstream from the fluid flow motor. The filter chamber includes an outlet fluidiy communicating the filter chamber and the fluid flow motor and a tangential inlet fluidiy communicating the cyclonic separator and the filter chamber.

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03-05-2011 дата публикации

Air cleaner including constant current power supply

Номер: CA2657506C
Автор: John Relman Bohlen
Принадлежит: Oreck Holdings LLC

An air cleaner (100) including a constant current power supply (102) is provided according to an embodiment of the invention. The air cleaner (100) includes a collector cell (110) and the constant current power supply (102) coupled to the collector cell (110). The constant current power supply (102) is configured to maintain a substantially constant electrical current output to the collector cell (110), compare an output voltage of the constant current power supply (102) to an upper voltage threshold VU and to a lower voltage threshold VL, and shut down the constant current power supply (102) if the output voltage is not between the upper voltage threshold VU and the lower voltage threshold VL.

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10-01-2008 дата публикации

Air cleaner and air cleaner diagnostic process

Номер: US20080006158A1
Принадлежит: Oreck Holdings LLC

An air cleaner is provided according to the invention. The air cleaner includes a printed circuit board (PCB) configured to operate the air cleaner and a diagnostics circuit. The diagnostics circuit is configured to receive a predetermined diagnostic initiation sequence in the air cleaner, initiate a diagnostics process for one or more operational features of the air cleaner in response to the predetermined diagnostic initiation sequence, and generate a diagnostics determination as a result of the diagnostics process.

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02-09-2021 дата публикации

Efficient genome editing in primary myeloid cells

Номер: WO2021173729A2
Принадлежит: Genentech, Inc.

Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

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03-02-1903 дата публикации

Sash fastener

Номер: CA79249A
Автор: John Bohlen
Принадлежит: Individual

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16-08-2007 дата публикации

Air cleaner for ozone and volatile organic compound (voc) removal

Номер: CA2638015A1
Автор: John Relman Bohlen
Принадлежит: Individual

An air cleaner (100) for ozone and Volatile Organic Compound (VOC) removal is provided according to an embodiment of the invention. The air cleaner (100) includes an air channel (101) in the air cleaner (100), an air moving unit (103) located in the air channel (101) and configured to create an airflow, and a combination ozone/VOC removing element (105) located in the air channel (101). The combination ozone/VOC removing element (105) substantially removes ozone and VOCs in the airflow.

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04-01-2023 дата публикации

Efficient genome editing in primary myeloid cells

Номер: EP4110903A2
Принадлежит: Genentech Inc

Provided herein, inter alia , are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells ( e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

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21-09-2023 дата публикации

Efficient genome editing in primary myeloid cells

Номер: US20230295665A1
Принадлежит: Genentech Inc

Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

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02-09-2021 дата публикации

Efficient genome editing in primary myeloid cells

Номер: CA3173287A1
Принадлежит: Genentech Inc

Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

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21-10-2021 дата публикации

Efficient genome editing in primary myeloid cells

Номер: WO2021173729A3
Принадлежит: Genentech, Inc.

Provided herein, inter alia , are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells ( e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

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16-07-2024 дата публикации

Handheld vacuum cleaner

Номер: US12035872B2
Принадлежит: Techtronic Industries Co Ltd

A vacuum cleaner including a dirty air inlet, a fluid flow path extending from the dirty air inlet to a clean air outlet, a fluid flow motor positioned in the fluid flow path, and a filter assembly positioned in the fluid flow path. The filter assembly including a first cylindrical filter and a second cylindrical filter nested within and removable from the first cylindrical filter. An inner diameter of the first cylindrical filter is smaller than an outer diameter of the second cylindrical filter such that the second cylindrical filter is compressed in order to be nested within the first cylindrical filter.

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16-08-2007 дата публикации

Air cleaner for ozone and volatile organic compound (voc) removal

Номер: WO2007092393A1
Автор: John Relman Bohlen
Принадлежит: Oreck Holdings, Llc

An air cleaner (100) for ozone and Volatile Organic Compound (VOC) removal is provided according to an embodiment of the invention. The air cleaner (100) includes an air channel (101) in the air cleaner (100), an air moving unit (103) located in the air channel (101) and configured to create an airflow, and a combination ozone/VOC removing element (105) located in the air channel (101). The combination ozone/VOC removing element (105) substantially removes ozone and VOCs in the airflow.

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