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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 17. Отображено 14.
12-10-2017 дата публикации

COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT

Номер: US20170290953A1
Автор: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard, BONASSAR LAWRENCE J, HARTL ROGER, BOWLES ROBERT D, GEBHARD HARRY H, Bonassar Lawrence J., Hartl Roger, Bowles Robert D., Gebhard Harry H.
Принадлежит: CORNELL UNIVERSITY

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

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Номер записи: 1
30-05-2017 дата публикации

Composite tissue-engineered intervertebral disc with self-assembled annular alignment

Номер: US0009662420B2
Автор: Lawrence J. Bonassar, Roger Hartl, Robert D. Bowles, Harry H. Gebhard, BONASSAR LAWRENCE J, HARTL ROGER, BOWLES ROBERT D, GEBHARD HARRY H, Bonassar Lawrence J., Hartl Roger, Bowles Robert D., Gebhard Harry H.
Принадлежит: Cornell University, UNIV CORNELL

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

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Номер записи: 2
28-03-2013 дата публикации

COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT

Номер: US20130079881A1
Автор: Bonassar Lawrence J., Bowles Robert D., Gebhard Harry H., Hartl Roger
Принадлежит: CORNELL UNIVERSITY

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. 1. A tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal , said IVD comprising:a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein andan annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen, wherein collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure.2. The tissue-engineered IVD according to claim 1 , wherein the nucleus pulposus structure comprises an alginate gel.3. The tissue-engineered IVD according to claim 2 , wherein the alginate gel comprises about 0.5% to about 10% (w/v) alginate.4. The tissue-engineered IVD according to claim 1 , wherein the first population of cells are present in a concentration of about 1×10cells/ml to about 50×10cells/ml.5. The tissue-engineered IVD according to claim 1 , wherein the first population of cells secrete proteoglycan.6. The tissue-engineered IVD according to claim 1 , wherein the first population of cells comprise nucleus ...

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Номер записи: 3
31-01-2019 дата публикации

METHODS FOR DETERMINING TISSUE ENGINEERED CONSTRUCT READINESS

Номер: US20190030210A1
Автор: Bartell Lena R., Bonassar Lawrence J., Cohen Itai, Middendorf Jill M.
Принадлежит:

The present invention relates to methods of determining if a tissue engineered construct is ready for implantation. In one aspect the method involves providing a tissue engineered construct comprising a scaffold having pores, analyzing the tissue engineered construct for buckling of pores, and determining whether the tissue engineered construct is ready for implantation based on the analysis. In another aspect, the invention relates to a method that involves non-destructive methods for determining whether a tissue engineered construct is ready for implantation. 1. A method of determining if a tissue engineered construct is ready for implantation , said method comprising:providing a tissue engineered construct comprising a scaffold having pores;analyzing the tissue engineered construct for buckling of pores; anddetermining whether the tissue engineered construct is ready for implantation based on said analyzing.2. The method according to claim 1 , wherein the tissue engineered construct is selected from the group consisting of a tissue engineered cartilage construct claim 1 , a tissue engineered bone construct claim 1 , a tissue engineered tendon construct claim 1 , a tissue engineered ligament construct claim 1 , and a tissue engineered heart valve construct.3. The method according to claim 1 , wherein the tissue engineered construct is a human tissue engineered construct.4. The method according to claim 1 , wherein said providing comprises:seeding cells onto a scaffold; andculturing the cells to form a tissue engineered construct.5. The method according to claim 1 , wherein said analyzing comprises:compressing the tissue engineered construct;detecting whether pores of the scaffold of the tissue engineered construct buckled.6. The method according to claim 5 , wherein said compressing comprises:staining the tissue engineered construct;mounting the tissue engineered construct on a tissue deformation imaging stage; andcompressing the constructs using axial compression ...

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Номер записи: 4
27-05-2021 дата публикации

DEVICE AND SYSTEM FOR REPAIRING INTERVERTEBRAL DISC HERNIATION AND METHODS OF USE

Номер: US20210153854A1
Автор: Bonassar Lawrence J., Chen Si, CUNHA-GAVIDIA Anny, Hartl Roger, MCCARTER Monika, MESSINA Michael, SHIBU Gayathri
Принадлежит:

A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device. 1. A device comprising: a palm portion and a sheath portion extending from one end of the palm portion;', 'a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe, wherein when the syringe is positioned on the adjustable platform, the needle rests in the sheath portion; and', 'a bidirectional trigger mechanism connected to the adjustable platform, wherein adjustment of the bidirectional trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform along the slot away from the sheath;, 'a housing comprisinga light element connected to the housing and capable of directing light along the sheath portion away from the palm portion; anda power source electrically coupled to the light element to provide electrical power to the light element.2. The device according to claim 1 , wherein the sheath portion comprises a first channel for receiving a needle and a second channel for receiving the light element ...

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Номер записи: 5
15-07-2021 дата публикации

Composite tissue-engineered intervertebral disc with self-assembled annular alignment

Номер: US20210213168A1
Автор: Harry H. Gebhard, Lawrence J. Bonassar, Robert D. Bowles, Roger Hartl
Принадлежит: CORNELL UNIVERSITY

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

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Номер записи: 6
27-06-2019 дата публикации

BIOMIMETIC BOUNDARY LUBRICANTS FOR ARTICULAR CARTILAGE

Номер: US20190194564A1
Автор: Bonassar Lawrence J., Putnam David, Samaroo Kirk J., Tan Mingchee
Принадлежит: CORNELL UNIVERSITY

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol. 1. A method for imparting a suitable level of lubricity to a biological tissue which comprises contacting said biological tissue with an sufficient amount of a composition to impart suitable lubricity , said composition comprising a graft brush copolymer with a pAA backbone or a graft brush copolymer comprising (i) a polyanionic backbone having a polydispersity index ranging from 1.0 to about 1.5 and a molecular weight ranging from about 50 kDa to about 200 kDa , (ii) brush segments having a molecular weight ranging from about 1 kDa to about 20 kDa , and (iii) at least one functionalizable group , selected from thiol and amine groups , located on at least one of the two terminal ends of the polyanionic backbone.2. The method of claim 1 , wherein contacting is by injecting claim 1 , infusing claim 1 , implanting claim 1 , coating or spraying.3. The method of claim 1 , wherein said biological tissue is selected from joints and cartilage.4. The method of claim 1 , wherein said biological tissue is a joint.5. The method of claim 4 , wherein said joint is an injured joint or an arthritic joint.6. The method of claim 4 , wherein said biological tissue is ocular claim 4 , nasal claim 4 , a tendon claim 4 , a tendon capsule or vaginal tissue.7. The method of claim 1 , wherein said polyanionic backbone has a molecular weight ranging from about 50 kDa to about 150 kDa.8. The method of claim 7 , wherein said polyanionic backbone has a molecular weight range ranging from about 50 kDa to about 100 kDa.9. The method of claim 7 , wherein said polyanionic backbone has ...

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Номер записи: 7
27-08-2015 дата публикации

COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT

Номер: US20150238657A1
Автор: Bonassar Lawrence J., Bowles Robert D., Gebhard Harry H., Hartl Roger
Принадлежит:

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. 1. A method of fabricating a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal , said method comprising:providing a first gel comprising a first population of living cells that secrete a hydrophilic protein;forming the first gel into a predetermined shape and size;providing a second gel comprising a second population of living cells and type I collagen;contacting the formed first gel with the second gel at a region that extends circumferentially around the first gel; andstoring the first and second gels under conditions effective for the collagen in the second gel to align circumferentially around the first gel by self-assembly of collagen due to cell-mediated gel contraction in the second gel, wherein the first gel forms a nucleus pulposus structure and the second gel forms an annulus fibrosus structure surrounding and in contact with the nucleus pulposus structure, thereby fabricating a tissue-engineered IVD suitable for total disc replacement in a mammal.2. The method according to claim 1 , wherein the first gel is an alginate gel comprising about 0.5% to about 10% (w/v) alginate.3. The method according to claim 1 , wherein the first population of cells is present in the first gel at a ...

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Номер записи: 8
01-10-2015 дата публикации

Biomimetic boundary lubricants for articular cartilage

Номер: US20150275118A1
Автор: David Putnam, Kirk J. Samaroo, Lawrence J. Bonassar, Mingchee Tan
Принадлежит: CORNELL UNIVERSITY

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol.

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Номер записи: 9
05-12-2019 дата публикации

Composite tissue-engineered intervertebral disc with self-assembled annular alignment

Номер: US20190365949A1
Автор: Harry H. Gebhard, Lawrence J. Bonassar, Robert D. Bowles, Roger Hartl
Принадлежит: CORNELL UNIVERSITY

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

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Номер записи: 10
15-04-2004 дата публикации

In vitro culture of tissue structures

Номер: WO2004030626A2
Автор: Charles A. Vacanti, Koji Kojima, Lawrence J. Bonassar, Martin P. Vacanti, Roland D. Eavey, Syed H. Kamil
Принадлежит: Massachussetts Eye & Ear Infirmary, The University Of Massachussetts

A method for growing a tissue structure includes providing a scaffold having the shape of the tissue structure and seeding the scaffold with tissue precursor cells. The seeded scaffold is then grown in vitro under conditions and for an incubation time sufficient for the tissue precursor cells to produce tissue on the scaffold and to from a tissue structure that can be implanted into a patient without causing an immune response.

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Номер записи: 11
14-11-2023 дата публикации

Device and system for repairing intervertebral disc herniation and methods of use

Номер: US11812939B2
Автор: Anny CUNHA-GAVIDIA, Gayathri SHIBU, Lawrence J. Bonassar, Michael Messina, Monika MCCARTER, Roger Hartl, Si Chen
Принадлежит: CORNELL UNIVERSITY

A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.

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Номер записи: 12
26-08-2015 дата публикации

Biomimetic boundary lubricants for articular cartilage

Номер: EP2908861A1
Автор: David Putnam, Kirk J. Samaroo, Lawrence J. Bonassar, Mingchee Tan
Принадлежит: CORNELL UNIVERSITY

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.

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Номер записи: 13
25-01-2024 дата публикации

Tissue-engineered intervertebral disc with living cells

Номер: US20240024537A1
Автор: Harry H. Gebhard, Lawrence J. Bonassar, Robert D. Bowles, Roger Hartl
Принадлежит: CORNELL UNIVERSITY

The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

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Номер записи: 14