Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 3. Отображено 3.
02-04-2015 дата публикации

MICROCOMPOSITES FOR TREATMENT OF BONE

Номер: US20150093443A1
Автор: Botimer Gary, Inceoglu Serkan, Maskiewicz Victoria
Принадлежит:

Compositions having a drug-loaded microparticle and bone cement and methods of making such compositions are disclosed. Also disclosed are methods of employing such compositions for the treatment of injected joint spaces and bone disease. 1. A composition , comprising a particle comprising at least one drug and a porous solid , wherein the particle is dispersed in a bone cement.2. The composition of claim 1 , wherein the at least one drug is an antibiotic claim 1 , a bone growth factor or a chemotherapeutic claim 1 , or a combination thereof.3. The composition of claim 2 , wherein the antibiotic is selected from an aminoglycoside antibiotic claim 2 , a glycopeptide antibiotic claim 2 , a macrolide antibiotic claim 2 , fluoroquinolones claim 2 , sulfa claim 2 , tetracycline claim 2 , rifampin claim 2 , vancomycin claim 2 , cephalosporin claim 2 , penicillinc claim 2 , or a combination thereof.4. The composition of claim 2 , wherein the antibiotic is gentamicin.5. The composition of claim 1 , wherein the porous solid comprises a non-erodible particulate system.6. The composition of claim 1 , wherein the porous solid comprises silica.7. The composition of claim 1 , wherein the particle has a size of about 2 μm to about 200 μm.8. The composition of claim 1 , wherein the bone cement is selected from ALLEGIANCE claim 1 , BONESOURCE claim 1 , CRANIOPLASTIC claim 1 , ORTHOCOMP claim 1 , OSTEOBOND claim 1 , PALACOS claim 1 , PALACOS E-FLOW claim 1 , SIMPLEX P claim 1 , SUCOUR claim 1 , and VERTIFIX.9. The composition of claim 1 , wherein the drug-loading of the particle is about 1% to about 70% by weight of the particle.10. The composition of claim 1 , wherein the drug-loading of the particle is less than about 40% by weight of the particle.11. The composition of claim 1 , wherein the weight ratio of particle to bone cement is about 1:9 to about 7:3.12. The composition of claim 1 , wherein the at least one drug is released over a period of 14 days to 70 days.13. The ...

Подробнее
Номер записи: 1
19-02-2019 дата публикации

Microcomposites for treatment of bone

Номер: US10207028B2
Автор: Gary Botimer, Serkan Inceoglu, Victoria Maskiewicz
Принадлежит: LOMA LINDA UNIVERSITY

Compositions having a drug-loaded microparticle and bone cement and methods of making such compositions are disclosed. Also disclosed are methods of employing such compositions for the treatment of injected joint spaces and bone disease.

Подробнее
Номер записи: 2
30-11-2006 дата публикации

Expandable surgical reaming tool

Номер: WO2006127904A1
Автор: Gary Botimer
Принадлежит: Gary Botimer

An expanding reamer for reaming or cutting a concave surface, for example, for reaming an acetabulum in preparation for implanting a prosthetic component during a hip arthroplasty. A rotating shaft cooperates with a surgical drill or other power source at one end and rotates a reamer head at the other end, and an actuation system expands one or more blades on the reamer head. The reamer head comprises one or more cutting blades, which act as segments of a cutting sphere, wherein the blades are expandable in directions non- parallel to the plane of the respective blades in order to enlarge the cutting sphere. Upon rotation of the reamer head, the blade(s) form a portion of an effective cutting sphere that is preferably greater-than-180-degrees; this allows greater flexibility in placement of the shaft of the reamer relative to the surface being reamed, for example, relative to the center of axis of the acetabulum. In one embodiment, two parallel blades move out away from each other and away from the rotational axis of the device, staying parallel to each other to become, in effect, more distanced, but still parallel, segments of a larger cutting sphere. In another embodiment, two blades start generally parallel to each other and to the rotational axis of the device, but pivot out from each other in directions generally perpendicular to their respective blade planes, again becoming more distanced, but not parallel, segments of a larger cutting sphere.

Подробнее
Номер записи: 3