09-04-2014 дата публикации
Номер: CN103709221A
Принадлежит:
Provided is a preparation method for cordycepin. The preparation method comprises the following steps: a solvent is added in adenosine, then water is added, acetoxyisobutyryl bromide is dropwisely added at the room temperature, and after dropwise addition, the mixture is stirred for 0.8-1.2h; vacuum concentration is carried out, a saturated sodium bicarbonate solution is added with stirring, then the mixture is extracted through ethyl acetate, the extract phase is acquired, then subjected to washing, drying, suction filtration and vacuum concentration, and the compound I is obtained; a solvent is added in the compound I, the mixture is cooled in ice bath, reducing agents are added under protection of nitrogen, stirring is carried out for 0.8-1.2h at the temperature of 3-5 DEG C, then the temperature is risen to the room temperature and stirring is carried out for 11-13h, vacuum concentration is carried out, a saturated ammonium chloride solution is added, the mixture is stirred and extracted ...
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