23-06-2023 дата публикации
Номер: CN116284216A
Автор:
ZHOU MENG,
LI JIANWEI,
YANG KANG,
WEI DAN,
LIN YING,
ZHAO YADONG,
LUO WEI,
YAN CHENLONG,
LU LIN,
SUN XIKAI,
HUANG XIN,
YU JIE,
CAI YUHANG,
LU KAIXU
Принадлежит:
The invention relates to the technical field of compound synthesis, and discloses an aromatic dipeptide functionalized sulfhydryl compound, which is prepared by the following steps: adding 3, 5-bis (methylthio) benzoic acid and pyridine into a triphenylmethyl chloromethane solution, fully reacting, and purifying to obtain 3, 5-bis (triphenylmethylthio) benzoic acid; the preparation method comprises the following steps: dissolving 2, 5-dioxopyrrolidine-1-yl 3, 5-bis ((triphenylmethylthio) methyl) benzoate in an organic solvent, mixing with N-hydroxysuccinimide, dissolving in the organic solvent, adding EDC.HCl, fully reacting, and purifying to obtain 2, 5-dioxopyrrolidine-1-yl 3, 5-bis ((triphenylmethylthio) methyl) benzoate; then adding phenylalanine-tryptophan and triethylamine, fully reacting, and purifying to obtain (3, 5-bis ((triphenylmethylthio) methyl) benzoyl) tryptophan phenylalanine; and then adding trifluoroacetic acid and triethyl silane, fully reacting, and purifying to obtain ...
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