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Применить Всего найдено 4. Отображено 4.
04-04-2013 дата публикации

NANOPARTICLES FOR DELIVERY OF BIOACTIVE AGENTS

Номер: US20130084312A1
Автор: APPAJOSYULA Sireesh, CAPUTO Gregory A., Sun Yaquan, Yu Lei
Принадлежит: ROSE PHARMACEUTICALS, LLC

Biocompatible polymeric nanoparticles for delivery of bioactive agents, and methods for preparing the particles, are described. Polyoxalate nanoparticles of the subject technology show desired particle sizes suitable for use in drug delivery and a substantially uniform or narrow particle size distribution. The polyoxalate nanoparticles can contain water-soluble, poorly water-soluble, or water-insoluble drugs. The nanoparticles are nontoxic and are generally safe for use in humans. After being administered into the body, the nanoparticles with a high content of a bioactive agent entrapped therein can safely deliver the agent to target sites and stably release the drug at a controlled rate. 1. Polyoxalate nanoparticles having diameters ranging from about 50 to about 300 nm.2. A method for preparing biocompatible nanoparticles of polyoxalate polymers , comprising:(a) mixing 1,4-cyclohexanedimethanol (CDE) with oxalyl chloride (OC) in the presence of dichloromethane (DCM), and triethylamine to produce polyoxalate polymer; and(b) adding the polyoxalate polymer to a solution of polyvinylalcohol (PVA) in the presence of a suitable solvent to produce a substantially homogenous emulsion of polyoxalate nanoparticles.3. The method of claim 2 , wherein the produced polyoxalate nanoparticles have diameters ranging from about 50 to about 300 nm.4. The method of claim 2 , further comprising at least one of drying the nanoparticles or dispersing the nanoparticles in an aqueous solution.5. The method of claim 2 , wherein the suitable solvent comprises at least one of water claim 2 , dichloromethane claim 2 , acetonitrile claim 2 , chloroform claim 2 , dimethylformamide claim 2 , tetrahydrofuran claim 2 , ethanol claim 2 , ethyl acetate claim 2 , or acetone.6. A method claim 2 , for preparing polyoxalate nanoparticles for delivery of a drug claim 2 , comprising:(a) mixing 1,4-cyclohexanedimethanol (CDE) with oxalyl chloride (OC) in the presence of dichloromethane (DCM), and ...

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Номер записи: 1
26-12-2013 дата публикации

Use of Silver-Containing Layers at Implant Surfaces

Номер: US20130344123A1
Автор: CAPUTO Gregory A., HETTINGER Jeffrey, KRCHNAVEK Robert, OSTRUM Robert
Принадлежит: ROWAN UNIVERSITY

The disclosure relates to coatings that contain silver, either in the form of metallic silver, silver oxides, salts of silver, or combinations of these. The silver is present in a microparticulate or nanoparticulate form, which exerts antimicrobial activity when bacteria (e.g., in a body fluid) contact the coated surface. The coatings are applied through accumulation of silver-containing particles on the surface, such as by sputtering or electron beam vapor deposition. As a result, their thickness, particle size, and density can be controlled. Furthermore, the surface can also be coated with other substances, such as diamond-like carbon or alumina, either as a discrete layer or intermixed with the silver-containing particles. 1. An article that is implantable in an animal , the article comprising a microparticulate silver-containing antimicrobial layer stably adhered upon at least one surface of the article.2. The article of claim 1 , wherein the antimicrobial layer is stably adhered upon substantially the entire surface of the article.3. The article of claim 1 , wherein the antimicrobial layer is composed substantially entirely of microparticulate silver metal (Ag).4. The article of claim 1 , wherein the antimicrobial layer comprises at least two of Ag claim 1 , AgO claim 1 , AgO claim 1 , AgON claim 1 , and AgON.5. The article of claim 1 , wherein the antimicrobial layer comprises diamond-like carbon (DLC).6. The article of claim 5 , wherein the antimicrobial layer comprises a substantially uniform mixture of DLC and silver-containing microparticles.7. The article of claim 5 , wherein the antimicrobial layer comprises a proximal zone having a higher ratio of silver-containing microparticles to DLC than a distal zone.8. The article of claim 1 , wherein the antimicrobial layer is laminated between the surface of the article and an exterior layer comprising DLC.9. The article of claim 8 , wherein the exterior layer consists essentially of DLC and has a porosity ...

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Номер записи: 2
20-12-2012 дата публикации

Nanoparticles for delivery of bioactive agents

Номер: WO2012174020A2
Автор: Gregory A. CAPUTO, Lei Yu, Sireesh APPAJOSYULA, Yaquan Sun
Принадлежит: ROSE PHARMACEUTICALS, LLC

Biocompatible polymeric nanoparticles for delivery of bioactive agents, and methods for preparing the particles, are described. Polyoxalate nanoparticles of the subject technology show desired particle sizes suitable for use in drug delivery and a substantially uniform or narrow particle size distribution. The polyoxalate nanoparticles can contain water-soluble, poorly water-soluble, or water-insoluble drugs. The nanoparticles are nontoxic and are generally safe for use in humans. After being administered into the body, the nanoparticles with a high content of a bioactive agent entrapped therein can safely deliver the agent to target sites and stably release the drug at a controlled rate.

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Номер записи: 3
16-05-2017 дата публикации

Use of silver-containing layers at implant surfaces

Номер: US09649338B2
Автор: Gregory A Caputo, Jeffrey Hettinger, Robert KRCHNAVEK, Robert OSTRUM
Принадлежит: ROWAN UNIVERSITY

The disclosure relates to coatings that contain silver, either in the form of metallic silver, silver oxides, salts of silver, or combinations of these. The silver is present in a microparticulate or nanoparticulate form, which exerts antimicrobial activity when bacteria (e.g., in a body fluid) contact the coated surface. The coatings are applied through accumulation of silver-containing particles on the surface, such as by sputtering or electron beam vapor deposition. As a result, their thickness, particle size, and density can be controlled. Furthermore, the surface can also be coated with other substances, such as diamond-like carbon or alumina, either as a discrete layer or intermixed with the silver-containing particles.

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Номер записи: 4