Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs. The definitions of the substituent groups in the formula are provided in the specification. The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24,J82, prostate cancer LNCap, PC-3, rectal cancer HCT8,HCT116,RkO, and the like.

SUBSTITUTE DIPHENYLAMINE COMPOUNDS USE THEREOF AS ANTITUMOR AGENTS

Provided is the use of substituted diphenylamine compounds of general formula I in preparing anti-tumour drugs. The compounds of general formula I have good anti-tumour activity, especially suitable for treating or relieving cancers caused by tumour cells in tissues and organs in a human body. The cancers preferably are colon cancer, lymphoma, lung cancer, esophagus cancer, breast cancer, central nervous system tumor, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostate cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, pharyngeal cancer or gastric cancer etc. The structure of the compound of general formula I is shown in formula (I).

Applications of Substituent Benzyloxy Group Containing Ether Compounds for Preparing Antitumor Drugs

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs. 2. The method according to claim 1 , whereinAr is Ar1, Ar2, Ar3, Ar4, or Ar16;{'sub': 1', '2', '3', '4', '5', '6', '7', '8', '9', '19', '20', '21', '22, 'Q is Q, Q, Q, Q, Q, Q, Q, Q, Q, Q, Q, Q, or Q;'}{'sub': 1', '2', '3', '4', '5', '6', '2', '2', '2', '2', '4', '1', '6', '1', '6', '3', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '8', '2', '8', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '1', '6', '1', '6', '1', '6', '1', '8', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '8', '1', '6', '10', '11', '10', '11', '10', '11', '2', '10', '11', '9', '8', '7', '1', '2, 'R, R, R, R, R, and Rare each independently H, halo, CN, NO, OH, NH, CHO, CO2H, CONa, CONH, C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, C-Calkoxy, C-Chaloalkoxy, C-Calkylthio, C-Chaloalkylthio, C-CalkoxyC-Calkyl, haloC-CalkoxyC-Calkyl, C-CalkoxyC-Calkoxy, haloC-CalkoxyC-Calkoxy, C-CalkylthioC-Calkyl, haloC-CalkylthioC-Calkyl, C-Calkylamino, C-Chaloalkylamino, C-Cdialkylamino, C-Chalodialkylamino, piperidinyl, pyrrolidinyl, N-methylpiperidinyl, morpholinyl, C-Calkenyl, C-Chaloalkenyl, C-Calkynyl, C-Chaloalkynyl, C-Calkenyloxy, C-Chaloalkenyloxy, C-Calkynyloxy, C-Chaloalkynyloxy, C-Calkylsulfonyl, C-Chaloalkylsulfonyl, C-Calkylsulfinyl, C-Chaloalkylsulfinyl, C-Calkylcarbonyl, C-Chaloalkylcarbonyl, C-Calkylcarbonyloxy, C-Calkylcarbonylamino, C-Calkylsulfonyloxy, C-Calkoxycarbonyl, C-Chaloalkoxycarbonyl, C-Calkylaminosulfonyl, C-Calkoxycarbonylamino, C-CalkoxycarbonylC-Calkyl, C-CalkoxycarbonylC-Calkoxy, aminoC-Calkyl, C-CalkylaminoC-Calkyl, C-CdialkylaminoC-Calkyl, C(═O)NRR ...

SUBSTITUTE DIPHENYLAMINE COMPOUNDS USE THEREOF AS ANTITUMOR AGENTS

Provided is the use of substituted diphenylamine compounds of general formula I in preparing anti-tumour drugs. The compounds of general formula I have good anti-tumour activity, especially suitable for treating or relieving cancers caused by tumour cells in tissues and organs in a human body. The cancers preferably are colon cancer, lymphoma, lung cancer, esophagus cancer, breast cancer, central nervous system tumor, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostate cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, pharyngeal cancer or gastric cancer etc. The structure of the compound of general formula I is shown in formula (I).

Substituted pyrimidine ammonia compound and use thereof

Disclosed is a substituted pyrimidine ammonia compound, as represented by Formula (I): See the description for the definition of each of the substituents in the formula. The compound represented by Formula (I) can be used in the prevention of plants diseases caused by a plurality of pathogenic bacteria such as oomycota, basidiomycota, ascomycota, and fungi imperfecti, and is particularly active against diseases such as powdery mildew of wheat.

VINYLARENE DERIVATIVE AND APPLICATION

The present invention relates to a vinylarene deriv. which modulates or inhibits the enzymic activity of indoleamine 2,3-dioxygenase 1 (IDO-1), and the use thereof, and further relates to a vinylarene deriv. and the use thereof. The vinylarene deriv. and its stereoisomer, cis- or trans-isomer, or tautomer thereof and pharmaceutically acceptable salt thereof, has an IDO-1 enzyme inhibitory activity, and is expected to provide brand new therapeutic methods and schemes for related diseases caused by IDO enzymes. 6. The application of a vinylarene derivative described in is characterized by: the compound shown in formula I claim 1 , its stereoisomer claim 1 , cis-trans isomer claim 1 , tautomer and pharmaceutically acceptable salt thereof claim 1 , or a combination thereof claim 1 , in the preparation of inhibitors of IDO-1 enzyme activity.7. The application of a vinylarene derivative described in is characterized by: its stereoisomer claim 1 , cis-trans isomer claim 1 , tautomer and pharmaceutically acceptable salt thereof claim 1 , or a combination thereof claim 1 , in the preparation of an anti-cancer drug claim 1 , a viral infectious agent claim 1 , a depressant claim 1 , an organ transplant rejection agent or an autoimmune enhancer.8. The application of a vinylarene derivative of is characterized by: the cancer is colon cancer claim 7 , pancreatic cancer claim 7 , breast cancer claim 7 , prostate cancer claim 7 , lung cancer claim 7 , ovarian cancer claim 7 , cervical cancer claim 7 , kidney cancer claim 7 , head and neck cancer claim 7 , lymphoma claim 7 , leukemia or melanoma.9. A pharmaceutical composition comprising any one or more compounds in claim 1 , its stereoisomer claim 1 , cis-trans isomer claim 1 , tautomer claim 1 , pharmaceutically acceptable salt thereof and pharmaceutically acceptable carriers or diluents. The invention relates generally to compounds vinylarene derivative that modulate or inhibit the enzymatic activity of indoleamine 2,3- ...

Substituted pyrimidine ether compounds and their use

Substituted pyrimidine ammonia compound and use thereof

Disclosed is a substituted pyrimidine ammonia compound, as represented by Formula (I): See the description for the definition of each of the substituents in the formula. The compound represented by Formula (I) can be used in the prevention of plants diseases caused by a plurality of pathogenic bacteria such as oomycota, basidiomycota, ascomycota, and fungi imperfecti, and is particularly active against diseases such as powdery mildew of wheat.

Substituted pyrimidine compound and uses thereof

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs. The definitions of the substituent groups in the formula are provided in the specification. The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24,J82, prostate cancer LNCap, PC-3, rectal cancer HCT8,HCT116,RkO, and the like.

Application of benzopyrone compound in preparation of anti-tumor drugs

The invention discloses an application of a benzopyrone compound represented by the general formula I in preparation of anti-tumor drugs, wherein in the formula, definitions of substituents are described the specification. The compound represented by the general formula I has a good anti-tumor activity, and especially has superior activity for resisting leukemia cell line HL-60, lung cancer A549, lung cancer H157, lung cancer H460, lung cancer H520, bladder cancer T24, bladder cancer J82, bladder cancer LNCap, prostate cancer PC-3 and the like.

Amino sulfonylureas compound with herbicidal activity and the application thereof

The present invention provides an amino sulfonylureas compound. The structure of the compound is shown in general formula I. The meanings of various substitute groups in the general formula are shown in the specification. The compound in general formula I or salts thereof have good herbicidal activity to weeds with broad leaf, especially to piemarker. It is possible to achieve a good herbicidal effect by using a low dose of the compound. Simultaneously, the compound is safe to corn, rice and wheat. Therefore, the invention also includes the application of the compound in general formula I or salts thereof used as herbicide in agriculture or other fields.

Substituted pyrimidine ether compounds and use thereof

The invention relates to substituted pyrimidine ether compounds having general formula I: The groups are as defined as specification. The compounds of formula I show high insecticidal activities for imagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as Tetranychus cinnabarinus . Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.

Use of substituted diphenylamine compounds in preparing anti-tumour drugs

Provided is the use of substituted diphenylamine compounds of general formula I in preparing anti-tumour drugs. The compounds of general formula I have good anti-tumour activity, especially suitable for treating or relieving cancers caused by tumour cells in tissues and organs in a human body. The cancers preferably are colon cancer, lymphoma, lung cancer, esophagus cancer, breast cancer, central nervous system tumor, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostate cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, pharyngeal cancer or gastric cancer etc. The structure of the compound of general formula I is shown in formula (I).

Substituted aryl ethers compounds as well as preparation and uses thereof

The invention belongs to the field of the agricultural pesticides and fungicides, in particular discloses a replaced aryl ether compounds and the preparation and application. The replaced aryl ether compounds of the invention are shown as the general formula (I): the general formula (I) compounds of the invention have the broad-spectrum activity--the compounds have very favorable control effects on the diseases such as the grape downy mildew, rice sheath blight, rice-blast disease, tomato late blight, powdery mildew, cucumber powdery mildew, cucumber downy mildew, cucumber gray mold, etc. The compounds of the invention simultaneously have very good insecticidal activity, have effects on a plurality of pests such as the armyworm, the diamondback moth, etc. and are very suitable for the integrated control of the pests on various crops.

Substituted pyrimidines as pharmaceuticals and insecticides

The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification: wherein definitions of substituents in the formula are as shown in the specification. The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew, puccinia sorghi , rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, the puccinia sorghi and the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths, myzus persicae , armyworms and tetranychus cinabarinus boisdu.

Application of phenyl ether compound with antitumor activity

The invention discloses an application of a phenyl ether compound as shown in general formula I in preparation of antitumor drugs. The compound of the general formula I has very good antitumor activity, and especially has excellent activity for human bladder cancer LNCap, T24, J82 and human prostate cancer PC-3.

Substituted aryl ethers compounds as well as preparation and uses thereof

The invention belongs to the field of the agricultural pesticides and fungicides, in particular discloses a replaced aryl ether compounds and the preparation and application. The replaced aryl ether compounds of the invention are shown as the general formula (I), wherein Ar represents Ar-1 or Ar-2. The general formula (I) compounds of the invention have the broad-spectrum activity--the compounds have very favorable control effects on the diseases such as the grape downy mildew, rice sheath blight, rice-blast disease, tomato late blight, powdery mildew, cucumber powdery mildew, cucumber downy mildew, cucumber gray mold, etc. The compounds of the invention simultaneously have very good insecticidal activity, have effects on a plurality of pests such as the armyworm, the diamondback moth, etc. and are very suitable for the integrated control of the pests on various crops.

Pesticide composition

The invention discloses a pesticide composition with a synergistic effect, which comprises two active components with the weight portion ratio of between 1:100 and 100:1, wherein the first active component is selected from 3-bromo-N-[4-chloro-2-methyl-6-[amino carbonyl] phenyl]-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-amide or N-oxide or a salt thereof; and the second active component is selected from any one of the following compounds with insecticidal activity: aryl pyrazoles, neonicotines, organic phosphoruses, carbamates, pyrethroids, benzoyl ureas, acylhydrazines, macrolide antibiotics, pyrroles, thioureas, Ryanicide receptor-ligands, mitochondrial electron transport inhibitors, nereistoxins, pyridalyls, indoxacarbs or Bacillus thuringiensis, or salts thereof.

Homopiperony lamine compound and application thereof

The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification, wherein definitions of substituents in the formula are as shown in the specification. The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew, puccinia sorghi, rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, the puccinia sorghi and the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths, myzus persicae, armyworms and tetranychus cinabarinus boisdu.

E-type Phenyl Acrylic Ester Compounds Containing Substituted Anilino Pyrimidine Group and Uses Thereof

Disclosed is a kind of E-type phenyl acrylic ester compound containing substituted anilino pyrimidine group, which is shown by general structure formula I, wherein each substituent is defined as that in the description. The compounds of general formula I show high insecticidal and acaricidal activities to adults and nymphs of harmful insects and mites in agricultural, civil and zoic technical fields, especially to Tetranychus cinnabarinus, Tetranychidae, and the like. The said compounds show more excellent performance on inhibiting the incubation of eggs of harmful mites. The uses of the said compounds as insecticides and/or acaricides in agricultural and other fields also are disclosed.

Application of benzonitrile compound in preparation of antitumor drugs

The invention discloses application of a benzonitrile compound shown as general formula I in preparation of antitumor drugs, and each substituent group in the formula is defined in the specification. The compound shown as the general formula I has very good anti-tumor activity, and especially has excellent activity on human lung cancer A549, human leukemia HL-60 and the like.

Substituted Pyrimidine Ether Compounds and use thereof

The invention relates to substituted pyrimidine ether compounds having general formula I: The groups are as defined as specification. The compounds of formula I show high insecticidal activities for imagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as Tetranychus cinnabarinus. Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.

SUBSTITUTE DIPHENYLAMINE COMPOUNDS USE THEREOF AS ANTITUMOR AGENTS

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

Substituted phenyl pyrazole ether compounds and application thereof

The invention discloses a substituent phenyl pyrazole aether compound and the application thereof. The structure of the compound is showed as general formula I: the definition of each substituent refers to the specification. The substituent phenyl pyrazole aether compound of the invention has broad spectrum of insecticide and acarid-killing activities and can prevent and treat acari and/or insects of the families and orders as follows: Tetranychidae (Tetranychus urticae, Tilia Tetranychus urticae, Tetranychus Cinnabarinus, Carpinus tetranychidae, Panonychus ulmi Koch, Panonychus citri McGregor, and etc.), Eriophyidae (hazel Phytoptidae, Eriophyes vitis, Eriophyes pyri Pagenstecher, and etc.), Tarsonemidae (primrose Steneotarsonemus furcatus, and etc.), hemiptera (Macrosiphum euphorbiae, Aphis fabae Scopli, peach aphid, and etc.), Lepidoptera (Spodoptera, Heliothis, Chilo, Codling moth, and etc.), Coleoptera (Lepinotarsa decemlineata, Phaedon armoraciae, and etc.), Diptera (Aedes, Culex, ...

Anthranilic acid compound and use thereof

The invention discloses an anthranilic acid compound, of which the structure is shown in a general formula I, wherein the definitions of substitutional groups are shown in an instruction book. The anthranilic acid compound has broad-spectrum insecticidal activity, and in particular to spodoptera exigua hubner and diamond back moth, the compound has better activity, and can also achieve good control efficiency under the condition of low dose.

E-type phenyl acrylic ester compounds containing substituted anilino pyrimidine group and uses thereof

Disclosed is a kind of E-type phenyl acrylic ester compound containing substituted anilino pyrimidine group, which is shown by general structure formula I, wherein each substituent is defined as that in the description. The compounds of general formula I show high insecticidal and acaricidal activities to adults and nymphs of harmful insects and mites in agricultural, civil and zoic technical fields, especially to Tetranychus cinnabarinus, Tetranychidae, and the like. The said compounds show more excellent performance on inhibiting the incubation of eggs of harmful mites. The uses of the said compounds as insecticides and/or acaricides in agricultural and other fields also are disclosed.

Use of benzonitrile compounds in preparing medicaments for treating tumor

Disclosed is a use of benzonitrile compounds of general formula (I) in preparing medicaments for treating tumor, wherein the substituted groups in formula (I) are as defined in description. Compounds of general formula (I) show good anti-tumor activity, especially excellent activity to human lung cancer A549, human leukemia HL-60, etc.

Substituted pyrimidine ammonia compounds and uses thereof

The invention relates to substituted pyrimidine ammonia compounds. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) can be used in the prevention of plants diseases caused by a plurality of pathogenic bacteria such as oomycota, basidiomycota, ascomycota, and fungi imperfecti, and due to these compounds have good bioactivity, which make them have very good effects at very low doses, especially more effective to powdery mildew of wheat. Therefore, the present invention relates to the use of the compounds having general formula I as fungicides, both in agriculture and other fields.

Substituted pyrimidine ether compounds and uses thereof

The invention discloses a compound used for substituting pyrimidine ether, the structure of the compound is shown as the general formula I; the definition of all substitutional groups in the general formula is detailed in the specification. The compound with the general formula I shows the high insecticidal activity on the imago, larva and eggs of harmful mites and insects in the technical field of agriculture, civilian use and animals. Meanwhile, the compound also shows better bactericidal activity. Therefore, the invention also includes the application of the compound with general formula I, wherein, the compound can be used as pesticide and/or bactericide in the agriculture field and other fields.

Substituted pyrimidine ether compounds and uses thereof

The invention discloses a compound used for substituting pyrimidine ether, the structure of the compound is shown as the general formula I; the definition of all substitutional groups in the general formula is detailed in the specification. The compound with the general formula I shows the high insecticidal activity on the imago, larva and eggs of harmful mites and insects in the technical field of agriculture, civilian use and animals. Meanwhile, the compound also shows better bactericidal activity. Therefore, the invention also includes the application of the compound with general formula I, wherein, the compound can be used as pesticide and/or bactericide in the agriculture field and other fields.

Amide compounds, preparation methods and uses thereof

Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including ostrinia nubilalis, sugarcane borer, adoxophyes orana fischer von roslerstamm, apple fruit borer, grapholitha inopinata, lymantri dispar l., cnaphalocrocis medinalis, ostrinia furnacalis, helicoverpa assulta, grapholitha inopinata, plutella xylostella, spodoptera exigua, prodenia litura etc., especially for plutella xylostella, spodoptera exigua. The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidalactivity which can be used to prevent rice blast, phytophthora infestans, cucumber downy mildew or grey mould of vegetables.

Amide compounds, preparation methods and uses thereof

Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including ostrinia nubilalis, sugarcane borer, adoxophyes orana fischer von reslerstamm, apple fruit borer, grapholitha inopinata, lymantri dispar l., cnaphalocrocis medinalis, ostrinia furnacalis, helicoverpa assulta, grapholitha inopinata, plutella xylostella, spodoptera exigua, prodenia litura etc., especially for plutella xylostella, spodoptera exigua. The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidal activity which can be used to prevent rice blast, phytophthora infestans, cucumber downy mildew or grey mold of vegetables.

O-formammidotiazol-benzamide compounds and use thereof

The invention discloses anthranilic diamide compounds and application thereof; the structures of the compounds are showed by a general formula I; the definitions of each substitutional group are seen in an instruction; the anthranilic diamide compounds of the invention have broad-spectrum insecticidal activity and is very effective to lepidopterous pests which include European corn borers, sugarcane borers, codling moths, lessorapple-worms and gypsy moths; the activity is especially better to diamond back moths; better effect can be obtained under low dosage. Simultaneously, a part of the compounds also have better sterilizing activity and can be used for controlling rice blasts, cucumber downy mildews and anthraxes.

Control device for improving PP cutting folding

The invention relates to the technical field of copper-clad plates, and discloses a control device for improving PP cutting folding, which comprises a main body mechanism, a flattening mechanism and a cutting mechanism, the flattening mechanism is located at the upper end of the main body mechanism, the cutting mechanism is located at the rear end of the flattening mechanism, and the main body mechanism comprises a bottom plate, a fixed plate, a straight rod, a fixed block and a movable wheel. The fixed plate is fixedly mounted at the upper end of the bottom plate, the straight rod is fixedly mounted at the upper end of the fixed plate, the fixed block is fixedly mounted at the right end of the straight rod, and the movable wheel is fixedly mounted at the right end of the fixed block. According to the control device for improving PP cutting and folding, by installing the flattening mechanism and the cutting mechanism, the problems that when PP is cut and led, the tension ratio is too poor ...

Substituted pyrimidine ether compounds and their use

The invention relates to substituted pyrimidine ether compounds having general formula I : The groups are as defined as specification. The compounds of formula I show high insecticidal activities for imagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as Tetranychus cinnabarinus.Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.

Substituted phenyl pyrazole ether compounds and application thereof

The invention discloses a substituent phenyl pyrazole aether compound and the application thereof. The structure of the compound is showed as general formula I: the definition of each substituent refers to the specification. The substituent phenyl pyrazole aether compound of the invention has broad spectrum of insecticide and acarid-killing activities and can prevent and treat acari and/or insects of the families and orders as follows: Tetranychidae (Tetranychus urticae, Tilia Tetranychus urticae, Tetranychus Cinnabarinus, Carpinus tetranychidae, Panonychus ulmi Koch, Panonychus citri McGregor, and etc.), Eriophyidae (hazel Phytoptidae, Eriophyes vitis, Eriophyes pyri Pagenstecher, and etc.), Tarsonemidae (primrose Steneotarsonemus furcatus, and etc.), hemiptera (Macrosiphum euphorbiae, Aphis fabae Scopli, peach aphid, and etc.), Lepidoptera (Spodoptera, Heliothis, Chilo, Codling moth, and etc.), Coleoptera (Lepinotarsa decemlineata, Phaedon armoraciae, and etc.), Diptera (Aedes, Culex, ...

Method for preparing 1, 1, 2-trimethoxyethane at normal pressure

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for preparing 1, 1, 2-trimethoxyethane under normal pressure. According to the method, 2-chloroacetaldehyde dimethyl acetal is taken as a raw material and reacts in the presence of a solvent and alkali at a certain temperature for a certain time, and a product is obtained through rectification and refining. The 1, 1, 2-trimethoxyethane prepared by the method disclosed by the invention is high in purity, low in cost, simple in equipment, high in safety, less in three wastes and environment-friendly, and has a relatively good industrial production practical value.

Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs. The definition of the substituent groups in the formula I are provided in the specification. The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24, J82, prostate cancer LNCap, PC-3, rectal cancer HCT8, HCT116, RkO and the like.

Pyrazolyl pyrilamine compound and use thereof

The present invention discloses a pyrazolyl pyrilamine compound, the compound has a structure as shown in formula (I), and the substituent groups in the (I) are as defined in the specification. The pyrazolyl pyrilamine compound has good control effects on downy mildew of cucumber, puccinia polysra, wheat powdery mildew and other diseases, and is especially better in the control effect on the downy mildew of cucumber.

Substitute diphenylamine compounds use thereof as antitumor agents

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

Substituted benzene urea compounds as well as preparation and uses thereof

The invention disclsoes a replaced phenylurea compound and preparation and application thereof. The structure of the replaced phenylurea compound is shown as in the general formula I: see the specification for the definitions of various substituents. The replaced phenylurea compound of the invention has the broad-spectrum fungicidal activity, namely, and the invention can be used for controlling the diseases caused by a plurality of germs such as oomycetes, basidiomycetes, ascomycetes, and imperfect fungis, etc. on a plurality of crops. At the same time the compounds have very high biological activity so as to enable the very good effects to be obtained under a very low level of dosages. Part of compounds of the invention also have very good disinsection and acaricidal activity and can be used for controlling the pests and mites on a plurality of crops.

Application of substituted azole compound in preparation of anti-tumor drug

The invention discloses an application of a substituted azole compound represented by a general formula I in preparation of anti-tumor drugs. The compound represented by the general formula I has good anti-tumor activity, and especially has superior activity on human lung cancer A549, human leukemia HL-60 and the like.

Substituted pyrimidine ether compounds and their use

The invention relates to substituted pyrimidine ether compounds having general formula I : The groups are as defined as specification. The compounds of formula I show high insecticidal activities forimagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as Tetranychus cinnabarinus.Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.

Substituted pyrimidine compound and uses thereof

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Substituted pyrimidine compound and use thereof

The invention discloses a substituted pyrimidine compound. The structure of the compound is shown in a general formula (I), wherein each substituent is described in the specification. The compound has broad-spectrum sterilization, insecticidal and mite killing activity, has good prevention and control effects on diseases such as cucumber downy mildew, puccinia sorghi, wheat powdery mildew, rice blast and cucumber gray mold, and particularly has better prevention effects on the cucumber downy mildew, the puccinia sorghi, the rice blast and the like, and also has good prevention and control effects on aphids, tetranychus cinnabarinus, diamondback moths and armyworms, and good effects can be achieved under the condition of small dosage. The compound also has the characteristics of simplicity of a preparation method and the like.

E-type phenyl acrylic acid ester compound containing substituted anilino pyrimidine group and applications thereof

The invention discloses an E-type phenyl acrylic acid ester compound containing a substituted anilino pyrimidine group. The structure of the compound is shown in the general formula I, wherein each substituent in the general formula is as shown in the specification. The compound with the general formula I has high insecticidal activity to the imagoes, larvae and eggs of pest mites and insects in the technical field of agriculture, civil use and animal and better activity in particular to pest mites such as carmine spider mite, thus good effect can be achieved by using low dosage of the compound.

Phenoxyl pyrilamine compound and application

The invention discloses a phenoxyl pyrilamine compound which has a structural general formula I as shown in the specification, wherein definitions of substituents in the formula are as shown in the specification. The compound has broad-spectrum bactericidal, insecticidal and acaricidal activity, has excellent prevention and control effects on diamondback moths, armyworms, myzus persicae and tetranychus cinabarinus boisdu, and particularly has the better prevention effect on the myzus persicae and the tetranychus cinabarinus boisdu. The compound shows the good bactericidal activity at the same time, and a part of the compound has the excellent prevention and control effects on diseases such as cucumber downy mildew, wheat powdery mildew, puccinia sorghi and rice blast at a very low dose.

Method for preparing 4-aminomethylbenzoic acid

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for preparing 4-aminomethyl benzoic acid by taking urotropine as a catalyst. The preparation method comprises the following steps: taking p-halomethyl benzoic acid as a raw material, taking urotropine and ammonium carbonate as catalysts, and reacting with an amination reagent; and after the reaction, concentrating to remove ammonia, and crystallizing to obtain the 4-aminomethyl benzoic acid. The 4-aminomethylbenzoic acid prepared by the method is high in purity, low in cost, less in three wastes and environment-friendly, and has relatively good practical value in industrial production.

Amide-type compound as well as preparation method and application thereof

The invention discloses an amide-type compound as well as a preparation method and an application thereof. The structure of the amide-type compound is shown as a general formula I: each substitutional group is defined as an instruction book. The amide-type compound has broad spectrum insecticidal activity, is very effective to Lepidoptera pests comprising European corn borers, sugarcane borers, codling moths, laspeyresia pomonellas, gypsy moths, rice leaf rollers, corn borers, tobacco leaf moths, small fruit borers, diamond back moths, asparagus caterpillars, prodenia lituras, and the like, and has better activity for the asparagus caterpillars and the prodenia lituras, thereby achieving good effect with low dose. Meanwhile, part of the compound also has good sterilizing activity and can be used for preventing and treating rice blast, tomato late blight, cucumber downy mildew and vegetable gray mold.

Substituted pyrimidine ammonia compounds and uses thereof

The invention relates to substituted pyrimidine ammonia compounds. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) can be used in the prevention of plants diseases caused by a plurality of pathogenic bacteria such as oomycota, basidiomycota, ascomycota, and fungi imperfecti, and due to these compounds have good bioactivity, which make them have very good effects at very low doses, especially more effective to powdery mildew of wheat. Therefore, the present invention relates to the use of the compounds having general formula I as fungicides, both in agriculture and other fields.

Substitute diphenylamine compounds use thereof as antitumor agents

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

HOMOPIPERONY LAMINE COMPOUND AND USE THEREOF

The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification: 2. The compounds according to the claim 1 , characterized in that wherein general formula I:{'sub': 1', '1', '4', '1', '4', '3', '6', '1', '4', '1', '4', '3', '6', '3', '6', '3', '6', '3', '6', '1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4, 'Ris selected from halo, C-Calkyl, C-Calkyl substituted with multiple halo, C-Ccycloalkyl, C-Calkoxy, halo C-Calkoxy, C-Calkenyloxy, haloC-Calkenyloxy, C-Calkynyloxy, haloC-Calkynyloxy, C-Calkylsulfonyloxy, C-Calkylthio, C-Calkylsulfinyl, C-Calkylsulfonyl, NH, C-Calkylamino, di(C-Calkyl)amino, cyano C-Calkylamino, C-Calkylcarbonylamino, C-Calkoxycarbonylamino, C-Calkoxy C-Calkyl, C-Calkylthio C-Calkyl, C-Calkylsulfinyl C-Calkyl, C-Calkylsulfonyl C-Calkyl, hydroxyl C-Calkyl or C-Calkylcarbonyloxy C-Calkyl;'}{'sub': 2', '2', '1', '4', '1', '4', '1', '4, 'Ris selected from H, halo, CN, NO, C-Calkyl, C-Calkoxy or halo C-Calkoxy;'}{'sub': '3', 'Ris H;'}{'sub': 4', '1', '4', '1', '4', '1', '4', '1', '4', '3', '6', '1', '4', '1', '4', '2', '4', '2', '4', '2', '4', '2', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '3', '6', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '8', '1', '4', '1', '4', '1', '4', '2', '4', '2', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4', '1', '4', '1', '4', '1', '4, 'Ris selected from H, OH, H(C)═O, C-Calkyl, halo C-Calkyl, C-Calkoxy, haloC-Calkoxy, C-Ccycloalkyl, C-Calkylthio, C-Calkenylthio, C-Calkenyl, C-Calkynyl, haloC-Calkenyl, haloC-Calkynyl, C-Calkoxy C-Calkyl, halo C-Calkoxy C-Calkyl, C-CalkylthioC-Calkyl, haloC-CalkylthioC- ...

Substituted Pyrimidine Compound and Uses Thereof

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

homopiperonylamine compound and its application

resumo composto de homopiperonilamina e a aplicação da mesma a invenção divulga, no campo de fungicida e inseticida, um composto de homopiperonilamina em lâmina que possui uma fórmula estrutural geral i conforme mostrado a seguir na especificação: i em que as definições dos substitutos na fórmula são como mostradas na especificação. o composto mostrado como a fórmula geral i tem atividade bactericida e inseticida de amplo espectro no campo da agricultura. o composto mostrado como a fórmula geral i tem um bom efeito de prevenção sobre vários germes como mofo do pepino, mofo do trigo, fungo puccinia sorghi, fungo do arroz e mofo cinza do pepino e particularmente, ainda possui o bom efeito de prevenção e controle sobre o mofo do pepino, o puccinia sorghi e o mofo do trigo em uma dosagem mais baixa. ao mesmo tempo, uma parte do composto possui melhor atividade inseticida, e pode ser usada para prevenir e controlar várias pragas de insetos como traças diamante, myzus persicae, verme de pernas e tetranychus cinabarinus boisdu. 1/1 The homopiperonylamine compound and the application thereof the invention discloses in the field of fungicide and insecticide a homopiperonylamine compound having a general structural formula i as shown below in the specification: wherein the definitions of the substitutes in the formula are: as shown in the specification. The compound shown as general formula I has broad spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula i has a good preventive effect on various germs such as cucumber mold, wheat mold, puccinia sorghi fungus, rice fungus and gray cucumber mold and particularly, still has good prevention and control effect. about cucumber mold, puccinia sorghi and wheat mold at a lower dosage. At the same time, some of the compound has better insecticidal activity and can be used to prevent and control various insect pests such as diamond moths, myzus persicae, leg worm and ...

Vinylarene derivative and use thereof

Anthranilamide compounds and the use thereof

Anthranilamide compounds of formula I with broad-spectrum insecticide activity, wherein the substituents are as defined in the specification. The present compounds have good activity against lepidoptera pests at low dosage, including European corn borer, sugar cane snout moth, apple roller moth, apple budworm, tussock moth, rice leaf roller, maize borer, tabacco moth, small budworm, small plutellid, beet armyworm, tabacoo cutworm and the like, especially small plutellid and beet armyworm. The present compounds also have high activity against homoptera pests, such as aphides. Furthermore, some of said compounds have potent activity as bactericides, and can be useful in controlling rice blast, tomato later blight, cucumber downy mildew and vegetable gray mold.

compostos de pirimidina e amônia substituídos e seus usos.

compostos de pirimidina e amônia substituídos e seus usos. a presente invenção se refere a compostos de pirimidinaq e amônia substituídos. a estrutura dos compostos é representada tendo a fórmula geral (i): os grupos são como definidos no relatório descritivo da presente invenção. o composto representado pela fórmula geral (i) pode ser utilizado na prevenção de doenças em plantas causadas por uma pluralidade de bactérias patogênicas, tais como oomycota, basidiomycota e fungos imperfeitos, e devido ao fato destes compostos terem boa bioatividade, demostrando muito bons efeitos em doses muito baixas, estes são especialmente eficazes contra o míldio pulverulento de trigo. sendo assim, a presente invenção diz respeito à utilização dos compostos de fórmula geral i como fungicidas, tanto em agricultura quanto em outros campos.

Substituted pyrimidine ammonia compound and use thereof

Amide Compounds, Preparation Methods and Uses Thereof

Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including ostrinia nubilalis , sugarcane borer, adoxophyes orana fischer von reslerstamm, apple fruit borer, grapholitha inopinata, lymantri dispar l., cnaphalocrocis medinalis, ostrinia furnacalis, helicoverpa assulta, grapholitha inopinata, plutella xylostella, spodoptera exigua, prodenia litura etc., especially for plutella xylostella, spodoptera exigua . The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidal activity which can be used to prevent rice blast, phytophthora infestans, cucumber downy mildew or grey mould of vegetables.