REGRESSION TREE ANALYSIS AND CLASSIFICATION APPROACHES IS FORMING

La sélection d'un candidat de réalisation(s) de formation à partir d'une pluralité de réalisations de formation peut être effectuée par une analyse d'arbre de classification et de régression (CART) qui prend en compte les associations entre les propriétés pétrophysiques et géologiques. Par exemple, un procédé peut comprendre l'application d'une analyse CART à une pluralité de réalisations de formation utilisant une première propriété de formation comme indicateur dans l'analyse CART, la pluralité des réalisations de formation étant pour une deuxième propriété de formation et sont basées au moins en partie une propriété mesurée de formation, donnant ainsi une association entre la première et la deuxième propriétés pour chacune de la pluralité des réalisations de formation ; l'analyse d'une puissance de l'association de chacune de la pluralité des réalisations de formation ; et la sélection d'un candidat de réalisation de formation à partir d'une pluralité de réalisation de formation basée ...

PROCESSES AND SYSTEMS FOR the MANAGEMENT AND the ORDERING Of a MODULE OF COMMANDED' AUTOMATION

PROCEEDED Of LOCAL ROUTING AND TRANSCODER ADAPTS HAS THIS ONE

CLUSTER ANALYSIS FOR SELECTING RESERVOIR MODELS FROM MULTIPLE GEOLOGICAL REALIZATIONS

La présente invention concerne un dispositif informatique qui facilite l'organisation d'une pluralité de réalisations tridimensionnelles de données géographiques dans des tables respectives unidimensionnelles de valeurs de propriété géologique, chaque valeur de propriété géologique correspondant à un emplacement de grille tridimensionnel d'une réalisation tridimensionnelle respective de données géologiques. Le dispositif informatique facilite ensuite le groupement des tables unidimensionnelles dans deux regroupements de tables ou plus sur la base d'une comparaison d'emplacements géométriques des valeurs de propriété géologique à l'intérieur des tables respectives, et sélectionne au moins une réalisation de la pluralité de réalisations tridimensionnelles de données géographiques pour chacun des deux regroupements de tables ou plus. Les réalisations de données sélectionnées sont ensuite fournies à une interface utilisateur.

ISOLIERENDES ETIKETT

Compuestos derivados de aril hidroxietilamino piridinas y triazinas, metodo de preparacion; composicion farmaceutica que los comprende;y su uso en el tratamiento de enfermedades mediadas por la actividad de faah, tales como ansiedad, depresion, dolor, trastornos del sueno, trastornos alimentarios e inflamacion, entre otras.

Compuestos derivados de aril hidroxietilamino piridinas y triazinas, método de preparación, composición farmacéutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad de faah, tales como ansiedad, depresión, dolor, trastornos del sueño, trastornos alimentarios e inflamación, entre otras.

Product recovery from adsorption-separation purge fluids

Purge fluid from a vessel head in an adsorption process is distributed to recovery processes according to the purity of product contained in the fluid. Extract-rich fluid thus is routed directly to recovery of the extract product. Distribution preferably is determined by internal positioning of feed, desorbent and product streams in the adsorption vessel.

Medical device receptacle filling method and apparatus

An apparatus and method for dispersing fluid from a fluid dispersal line is provided. The method comprises initiating operation of the medical apparatus, determining whether fluid has been dispersed from the medical apparatus via the fluid dispersal line since said initiating occurred, and assessing whether fluid is available in the fluid dispersal line. If fluid has not been dispersed from the medical apparatus since said initiating occurred and fluid is not available in the fluid dispersal line, the method includes distributing a commanded quantity of fluid plus an amount of fluid determined to fill the fluid dispersal line. Otherwise the method disperses only the commanded quantity of fluid.

Method for measurement and calculation of dew point for fractionation column overheads

Methods for controlling the operation of fractionation columns to avoid column flooding are described. The methods use mass flow meters to measure the mass flow rates of the receiver vapor, and the stripper hydrocarbon liquid or stripper reflux and stripper net overhead. The water from the receiver can be measured with either a volumetric flow meter or a mass flow meter. A computer can be used to determine the dew point from the mass flows, and an alarm can be triggered and/or a process change can be made if the difference between the calculated dew point and the temperature of the overhead vapor stream is less than a predetermined amount.

Apparatus for measurement and calculation of dew point for fractionation column overheads

Apparatus for controlling the operation of fractionation columns to avoid column flooding is described. The apparatus uses mass flow meters to measure the mass flow rates of the receiver vapor, and the stripper hydrocarbon liquid stream or the stripper reflux and the stripper net overhead liquid. The water from the receiver can be measured with either a volumetric flow meter or a mass flow meter. The apparatus also includes at least one computer in communication with a molecular weight analyzer or specific gravity analyzer; an overhead vapor line pressure gauge; an overhead vapor line temperature gauge; a hydrocarbon liquid outlet line temperature gauge; the stripper hydrocarbon stream mass flow meter, or the stripper reflux hydrocarbon liquid mass flow meter and the stripper net overhead hydrocarbon liquid mass flow meter; the vapor mass flow meter; and the water flow meter.

Light-emitting polymer

A radiation-emitting polymer composition includes a polysiloxane polymer including tritium and a wavelength-shifter chemically bonded as a side chain to the polysiloxane polymer or chemically bonded as a side chain to a siloxane carrier dispersed within the polysiloxane polymer. The wavelength-shifter includes a plurality of cyclic chemical moieties and emits electromagnetic radiation in response to radiation emitted by the tritium.

Pest monitoring system with conductive electrodes

A pest monitoring system generally includes a circuit, wherein the circuit is initially in a first impedance state that is configured to change to a second impedance state due to pest activity, wherein the second impedance state is lower than the first impedance state.

Multi-component contact lens having posterior and anterior features

An ophthalmic device having posterior and anterior features are disclosed herein. An example ophthalmic device may include an enclosure having an insert disposed therein. The enclosure may include a cornea contact disposed on a posterior side and arranged to rest on a user's cornea outside of a central cornea area when the ophthalmic device is worn by a user. The enclosure further includes a channel formed in the posterior side, where the channel extends through the cornea contact from at least radially outside of the insert to an inner edge of the cornea contact, and a fenestration formed there through, wherein the fenestration is arranged radially outside of the insert and formed to intersect with a proximate end of the channel.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Pest control and detection system with conductive bait matrix

A pest control and detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant, consumable, and displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes at least one of a thermoplastic material and a resin.

Tattoo removal using a liquid-gas mixture with plasma gas bubbles

Methods and systems are disclosed for removing a tattoo from a subject's skin by application of a cold plasma that is delivered via a liquid-gas mixture. The plasma can be delivered in the form of gas bubbles, in which at least a portion of gas is in the form of a plasma.

Fuel dispensing nozzle

A pre-pay fuel system having a fuel nozzle with automatic cutoff provisions when a full tank exists or unwanted tank pressure conditions are detected is also provided with a low fuel pressure controlled cutoff. The fuel pressure cutoff allows rapid response to permit fuel flow when high pressure exists in the nozzle and provides a nozzle flow cutoff after a predetermined time delay when low fuel pressure exists in the nozzle.

ELECTROCHEMICAL ELECTRODES AND METHOD FOR FORMING A MEMBRANE RESPECTING ION FOR AN ELECTROCHEMICAL ELECTRODE AND METHOD FOR PRODUCING AN ELECTROCHEMICAL ELECTRODE

Hybrid magnetically suspended and rotated centrifugal pumping apparatus and method

An apparatus and method for a centrifugal pump (10) for pumping sensitive biologic fluid, which includes (i) an integral impeller and rotor (21) which is entirely supported by an integral combination of permanent magnets and electromagnetic bearings (52, 54) and rotated by an integral motor (40), (ii) a pump housing and arcuate passages (32, 34, 36) for fluid flow and containment, (iii) a brushless driving motor (40) embedded and integral with the pump housing, (iv) a power supply, and (v) specific electronic sensing of impeller position, velocity or acceleration using a self-sensing method and physiological control algorithm for motor speed and pump performance based upon input from the electromagnetic bearing currents and motor back emf -- all fitly joined together to provide efficient, durable and low maintenance pump operation. A specially designed impeller and pump housing provide the mechanism for transport and delivery of fluid through the pump to a pump output port with reduced fluid turbulence.

Hybrid magnetically suspended and rotated centrifugal pumping apparatus and method

An apparatus and method for a centrifugal fluid pump for pumping sensitive biological fluids, which includes (i) an integral impeller and rotor which is entirely supported by an integral combination of permanent magnets and electromagnetic bearings and rotated by an integral motor, (ii) a pump housing and arcuate passages for fluid flow and containment, (iii) a brushless driving motor embedded and integral with the pump housing, (iv) a power supply, and (v) specific electronic sensing of impeller position, velocity or acceleration using a self-sensing method and physiological control algorithm for motor speed and pump performance based upon input from the electromagnetic bearing currents and motor back emf—all fitly joined together to provide efficient, durable and low maintenance pump operation. A specially designed impeller and pump housing provide the mechanism for transport and delivery of fluid through the pump to a pump output port with reduced fluid turbulence.

Hybrid magnetically suspended and rotated centrifugal pumping apparatus and method

An apparatus and method for a centrifugal pump (10) for pumping sensitive biologic fluid, which includes (i) an integral impeller and rotor (21) which is entirely supported by an integral combination of permanent magnets and electromagnetic bearings (52, 54) and rotated by an integral motor (40), (ii) a pump housing and arcuate passages (32, 34, 36) for fluid flow and containment, (iii) a brushless driving motor (40) embedded and integral with the pump housing, (iv) a power supply, and (v) specific electronic sensing of impeller position, velocity or acceleration using a self-sensing method and physiological control algorithm for motor speed and pump performance based upon input from the electromagnetic bearing currents and motor back emf -- all fitly joined together to provide efficient, durable and low maintenance pump operation. A specially designed impeller and pump housing provide the mechanism for transport and delivery of fluid through the pump to a pump output port with reduced fluid turbulence.

Hybrid magnetically suspended and rotated centrifugal pumping apparatus and method

An apparatus and method for a centrifugal fluid pump for pumping sensitive biological fluids, which includes (i) an integral impeller and rotor which is entirely supported by an integral combination of permanent magnets and electromagnetic bearings and rotated by an integral motor, (ii) a pump housing and arcuate passages for fluid flow and containment, (iii) a brushless driving motor embedded and integral with the pump housing, (iv) a power supply, and (v) specific electronic sensing of impeller position, velocity or acceleration using a self-sensing method and physiological control algorithm for motor speed and pump performance based upon input from the electromagnetic bearing currents and motor back emf--all fitly joined together to provide efficient, durable and low maintenance pump operation. A specially designed impeller and pump housing provide the mechanism for transport and delivery of fluid through the pump to a pump output port with reduced fluid turbulence.

Aqueous processable, multilayer, photoimageable permanent coatings for printed circuits

The use of a two layer photoimageable, aqueous processable, resist with a hydrophic binder in the outermost layer provides a permanent coating highly resistant to printed circuit processing chemicals. This resistance results in levels of adsorbed or absorbed ionic contamination less than 14 micrograms per square inch.

Automatically pulsing different aspiration levels to an ocular probe

A first pump and second pump are used to apply aspiration to a probe. The first pump provides a low flow-rate aspiration to an aspiration port of a probe and the second pump provides a high flow-rate aspiration to the aspiration probe in response to a user input. The first pump may be a flow based pump and the second pump may be a vacuum based pump and provide an aspiration which is greater than the aspiration of the first pump, the second pump providing aspiration to the probe when there is substantial occlusion of the aspiration port.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Automatically switching different aspiration levels and/or pumps to an ocular probe

A method for applying aspiration and irrigation to a phacoemulsification device. The method includes applying a low flow-rate aspiration from a first pump to an aspiration port of a probe, applying a low flow-rate irrigation from a fluid source to an irrigation port of the probe while applying the low flow-rate aspiration, transitioning from the low flow rate aspiration to a high flow-rate aspiration from a second pump to the aspiration port, and transitioning from the low flow-rate irrigation to a high flow-rate irrigation while transitioning from the low flow-rate aspiration to the high flow-rate aspiration. Fig. 1 1115)

Automatically pulsing different aspiration levels to an ocular probe

Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner. Fig. 9A - ASPIRATE EYE WITH A FIRST PUMP IS PROBE NO INSUFFICIENTLY -- OCCLU-D-? OUTPUT COMMAND SIGNAL TO SWITCH TO A SECOND PUMP ASPIRATE EYE WITH THE SECOND PUMP IS PROBE YES INSUFFICIENTL OCCLUDED? OUTPUT COMMAND SIGNAL TO CHANGE BACKTO THE FIRST

Automatically switching different aspiration levels and/or pumps to an ocular probe

A method for applying aspiration and irrigation to a phacoemulsification device. The method includes applying a low flow-rate aspiration from a first pump to an aspiration port of a probe, applying a low flow-rate irrigation from a fluid source to an irrigation port of the probe while applying the low flow-rate aspiration, transitioning from the low flow rate aspiration to a high flow-rate aspiration from a second pump to the aspiration port, and transitioning from the low flow-rate irrigation to a high flow-rate irrigation while transitioning from the low flow-rate aspiration to the high flow-rate aspiration. Fig. I 1115)

Automatically switching different aspiration levels and/or pumps to an ocular probe

Incipient temperature excursion mitigation and control

Systems and methods are disclosed for detecting temperature excursion in a chemical plant or petrochemical plant or refinery. Aspects of the disclosure provide an enhanced control system for a reactor, such as in hydroprocessing. The enhanced control system may provide early warnings of impending undesirable events, directly or indirectly manipulate certain process variables to reduce undesirable outcomes, and/or directly or indirectly manipulate of certain process variables so as to place a reactor unit in a “safe park” state. This may avoid a high temperature trip, depressuration, associated operating risks, allow for faster recovery from temperature excursions, and/or avoid unplanned emergency shutdowns of the reactor, chemical process, plant, or refinery.

Stabilized bitumen compositions

Two or more different polymeric materials are stably incorporated into bitumen by effecting steric stabilization of a polyolefin, such as polyethylene, and by dispersing the other polymer, such as a styrene-butadiene-styrene copolymer, an ethylene-vinyl acetate copolymer or an EPDM copolymer in the stabilized polyethylene-bitumen composition. The ability to incorporate different polymeric materials in bitumen permits desirable modifications to the properties of the composition to be effected. In addition, different properties can be attained by modifying processing parameters.

流體噴注分配裝置

Photoactivated drug therapy

A series of articles and techniques for controlled pharmaceutical delivery within a patient is described. An article includes at least one cavity having an interior dimension equal to a resonant mode of electromagnetic radiation to which the article is exposed. A standing wave is created within the cavity, causing a change in a diffusion characteristic of at least one component of the cavity, in turn causing release of a pharmaceutical from the cavity into an area of the body surrounding the article. Low-energy, non-destructive electromagnetic radiation, such as visible or near-infrared light, can be used.

Fastr curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions

Side chamber process monitor for adsorptive separation process

Processes and apparatus for analyzing fluid properties of a stream are described. The processes utilize a simulated moving bed system and a rotary valve. The processes involve sending a portion of the pump-around stream to a side chamber where the moisture content of the adsorbent in the side chamber or one or more fluid properties of the stream or both are measured using an analyzer specific to each fluid property.

Pest control and detection system with conductive bait matrix

A pest control and/or detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant and/or consumable and/or displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes a thermoplastic material and/or a resin.

Stabilized bitumen compositions

Two or more different polymeric materials are stably incorporated into bitumen by effecting steric stabilization of a polyolefin, such as polyethylene, and by dispersing the other polymer, such as a styrene-butadiene-styrene copolymer, an ethylene-vinyl acetate copolymer or an EPDM copolymer in the stabilized polyethylene-bitumen composition. The ability to incorporate different polymeric materials in bitumen permits desirable modifications to the properties of the composition to be effected. In addition, different properties can be attained by modifying processing parameters.

Razor blades

RAZOR BLADE CONSTRUCTION HAVING DEFINED ANGULAR AND DIMENSIONAL LIMITS OF THE CONVERGING SURFACES FORMING THE CUTTING EDGE AND AN EFFECTIVE RECESSED PORTION IMMEDIATELY ADJACENT THERETO FOR IMPROVED CUTTING EASE AND SHAVING COMFORT.

Razor blade configuration

Training scripts

A training script device is described that conveniently allows a user to create a training script defining one or more steps of a workout routine, where each step may include an activity, a duration for performing that activity, and an intensity at which the activity is to be performed. Further, one or more steps of the training script can be self-starting in response to performance data detected by sensors of training script device executing the training script. This conveniently frees the athlete from having to continuously monitor the status of his or her workout activities. Still further, the training script device conveniently allows a user to transfer training scripts to other training script devices, so that athletes can share successful training scripts.

Pyrimidine derivatives as kinase modulators and method of use

The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wild­type Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a farmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR1R1a, or O-R1, wherein X is H, halo, C1-C6 alkyl, NO2, mono-, di-, or tri-halo substituted methyl, NR13R,14. C(O)O-C1-C6 alkyl, or N(R13)-C(O)-C1-C6 alkyl; Y is H, halo, OH, C1-C6 alkyl, C0-C6 alkyl-NR,15R16, NRI5R,6, C1-C6 alkoxy, -N(R13)-(CH2)n-­NR15R16, -C(O)O-C1-C6 alkyl, -O-(CH2)n-NR15R16, -C(O)-C1-C6 alkyl, -C0-C6-alkyl-R21, -O-R21, -C(O)-R21, -O-(CH2)n-R21, -C(O)-NR13R14, -C(O)-N(R13)-aryl, -C(O)-N(R13)­(CH2)n-NR15R16, -C(O)-N(R13)-(CH2)n-aryl -C(O)-N(R13)-(CH2)n-heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S. Z is H, NR2R3, -S-R2a, or -0-R2a

Low power wireless communication

Systems, devices, and techniques for establishing communication between two medical devices are described. In one example, an implantable medical device comprises communication circuitry, therapy delivery circuitry, and processing circuitry configured to initiate a communication window during which the implantable second medical device is capable of receiving the information related to a cardiac event detected by a first medical device, the communication window being one of a plurality of communication windows defined by a communication schedule that corresponds to a transmission schedule in which the first medical device is configured to transmit the information, control the communication circuitry to receive, from the first medical device, the information related to the cardiac event that is indicative of a timing of the cardiac event with respect to a timing of the communication window, schedule and control delivery of a therapy according to the information related to the cardiac event.

Method for automatically adjusting the sensitivity of cardiac sense amplifiers

Two mechanisms work together to adjust two variables independently so that the gain of an input amplifier used to find physiologic signals in an implantable medical device can be automatically adjusted to enhance the signal to noise ratio of the electrical input to said amplifier. The first determines whether there has been too long a time between senses found in the body's electrical input to the amplifier and if true, and no other conditions override that consideration, it adjusts the value of a long term average parameter which is used as a referent parameter to adjust the actual parameter that is used as the referent for making either a threshold level adjustment or gain change, depending on the structure of the particular design's circuitry and/or software. One set of adjustments to the gain referent parameter depends on the relative size of the long term average parameter and the gain referent parameter. The mechanisms preferably employ counting registers, the one which adjusts the gain referent having a process to weight input signals such that those of different types get different weights, and the other mechanism only accepting certain of the input signals. Input signals to the two mechanisms can be either physiologically based or from stimulation pulses issued from an implanted device, such as, for example a pacemaker.

Use of recovered power in a process

Processes and apparatus for recovering energy from a petroleum, petrochemical, or chemical process are disclosed. The process comprises providing a fluid process stream in a petroleum, petrochemical, or chemical process zone having a direct current power input; controlling a flow rate of the process stream by directing at least a portion of the process stream through a first power-recovery turbine to generate electric power as direct current therefrom; and providing the recovered direct current to the direct current power input of the process zone.

Hydroprocessing unit with power recovery turbines

Methods and apparatus for recovering power in a hydroprocessing process are described. The method involves the use of a power-recovery turbine in place of, or in addition to, a control valve. A hydrocarbon feed stream is combined with a portion of a hydrogen stream. The combined stream is heated, and the heated stream is introduced into a hydroprocessing reaction zone having at least two beds. The heated stream is contacted with a first hydroprocessing catalyst to form a first hydroprocessed stream. At least part of a portion of the hydrogen stream is combined with the first hydroprocessed stream to form a first quenched hydroprocessed stream. The first quenched hydroprocessed stream is contacted with a second hydroprocessing catalyst to form a second hydroprocessed stream. At least a portion of the second portion of the hydrogen stream is directed through a power-recovery turbine to generate electric power.

Use of recovered power in a process

Processes and apparatus for recovering energy from a petroleum, petrochemical, or chemical process are disclosed. The process comprises providing a fluid process stream in a petroleum, petrochemical, or chemical process zone having a direct current power input; controlling a flow rate of the process stream by directing at least a portion of the process stream through a first power-recovery turbine to generate electric power as direct current therefrom; and providing the recovered direct current to the direct current power input of the process zone.

JAK-2 Modulators and Methods of Use

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

Medical applications of orthogonal polarization spectral imaging

Medical applications of orthogonal polarization spectral (OPS) imaging technology are provided. This technology provides for a high contrast image of sub-surface phenomena such as blood vessel structure, blood flow within vessels, gland structure, etc., as well as a high resolution image of the surface of solid organs. Numerous clinical (diagnostic and therapeutic), as well as research applications of this technology, in the medical and pharmaceutical fields, are discussed.

Easy open flexible pouch

A flexible pouch is formed from a first and second sheet which are in sealing engaged along their side edges. Two gussets are provided at the top and bottom, respectively, of the sheets. The bottom of the uppermost gusset is recessed such that a pocket is formed at one end of the pouch. A compartment is formed within the pouch by the two sheets and the two gussets. A straw or other suitable instrument can be used to puncture the uppermost gusset in order to remove the contents from the compartment of the pouch. This pocket has a wide mouth and will enable easy insertion of the straw while minimizing or eliminating product spillage.

Methods and extraction units employing vapor draw compositional analysis

Embodiments of extraction unit and an analysis method are provided. In one embodiment, the analysis method includes the steps of providing a feed stream and a species-selective solvent to the distillation column, drawing a vapor sample from the distillation column, condensing the vapor sample, and analyzing at least a portion of the condensed vapor sample.

Data reproducing machine

Lubrication devices for scroll compressors

Record-controlled printing mechanism

Conical rotor with elongated nose portion

MOLDING PROCESS BY INJECTION OF OBJECTS PRESENTING AN INTERNAL ALVEOLAR OR CELLULAR STRUCTURE

MOULAGE PAR INJECTION. A L'AIDE D'UNE EXTRUDEUSE PRESENTANT UN INJECTEUR D'AGENT DE SOUFFLAGE ON EXTRUDE UN MELANGE DE RESINE ET D'AGENT DE SOUFFLAGE DANS UNE CHAMBRE D'INJECTION DANS LAQUELLE IL SE PRODUIT UNE DILATATION PARTIELLE DE LA RESINE, PUIS ON ARRETE L'ENVOI D'AGENT DE SOUFFLAGE EN LAISSANT L'EXTRUDEUSE EN FONCTIONNEMENT, DE SORTE QUE CELLE-CI EXTRUDE ALORS LA RESINE NON ALVEOLAIRE DANS LA MEME CHAMBRE D'INJECTION, PUIS ON ARRETE L'EXTRUSION, ON INTERROMPT LA COMMUNICATION ENTRE L'EXTRUDEUSE ET LA CHAMBRE D'INJECTION, ON FAIT COMMUNIQUER CETTE DERNIERE AVEC UN MOULE DANS LEQUEL ON INJECTE D'ABORD LA RESINE EXTRUDEE EN DERNIER, C'EST-A-DIRE LA RESINE ALVEOLAIRE, PUIS LA RESINE EXTRUDEE EN PREMIER, C'EST-A-DIRE LA RESINE NON ALVEOLAIRE. MOULAGE D'OBJETS DE DENSITE VARIABLE PRESENTANT UNE STRUCTURE INTERNE ALVEOLAIRE ET UNE SURFACE EXTERIEURE OU PEAU DENSE ET NON ALVEOLAIRE. INJECTION MOLDING. USING AN EXTRUDER PRESENTING AN INJECTOR OF BLOWING AGENT, A MIXTURE OF RESIN AND BLOWING AGENT IS EXTRUDED IN AN INJECTION CHAMBER IN WHICH PARTIAL EXPANSION OF THE RESIN OCCURRETS, THEN IS STOPPED. '' SENDING OF BLOWING AGENT LEAVING THE EXTRUDER RUNNING, SO THAT IT THEN EXTRUDES THE NON-ALVEOLAR RESIN IN THE SAME INJECTION CHAMBER, THEN THE EXTRUSION IS STOPPED, THE COMMUNICATION BETWEEN THE EXTRUDER IS INTERRUPTED AND THE INJECTION CHAMBER, THIS LATEST IS COMMUNICATED WITH A MOLD IN WHICH THE RESIN EXTRUDED LAST IS FIRST, THAT IS TO SAY THE ALVEOLAR RESIN, THEN THE RESIN EXTRUDED FIRST, IT IS - A-SAY THE NON-ALVEOLAR RESIN. MOLDING OF OBJECTS OF VARIABLE DENSITY PRESENTING AN INTERNAL ALVEOLAR STRUCTURE AND AN EXTERNAL SURFACE OR DENSE AND NON-ALVEOLAR SKIN.

Prodn. of injection foam mouldings - using single moulding machine and extruder and introducing blowing agent into the extruder

Foam moulded plastic prods. are produced using a single extruder connected to an injection chamber. Initially solid plastic resin is injected followed by foamed plastic resin formed by introducing blowing agent into the extruder. The vol. occupied from the blowing agent source to the injection nozzle is 1-40% of the total injection chamber volume. The correct amt. of each type of resin can be controlled and the process can be adapted to produce a solid sprue. Liquid colouring can be used without a change in method. A controlled skin thickness can be obtd. with only one extruder.

System management apparatus for a multiprocessor system

ABSTRACT OF THE DISCLOSURE A data processing unit includes a number of tightly coupled central subsystems, a number of peripheral subsystems, a main memory and a system management facility all coupled in common to a system bus. The system management unit has top priority on the system bus and includes centralized resources which provide apparatus for indicating the status of power and temperature, booting the subsystems, testing the subsystems, timing central subsystem functions, and allowing local and remote maintenance access to the subsystems. The system management facility receives commands from the central subsystem to read from and write into the timers as well as to read the status of the overall system. The system management facility generates special commands to the central subsystem to indicate when the timers have decremented to ZERO as well as special commands to aid in hardware and software debugging.

DEVICE FOR ADMINISTERING ANESTHETIC GAS TO A PATIENT

L'INVENTION CONCERNE UN DISPOSITIF D'ADMINISTRATION D'UN GAZ ANESTHESIQUE A UN PATIENT, COMPRENANT UN MASQUE 22, DES MOYENS POUR FOURNIR UN GAZ ANESTHESIQUE AU MASQUE QUAND LE PATIENT INHALE ET UNE LIGNE D'ECHAPPEMENT 24, 28 AYANT SON EXTREMITE LA PLUS PROCHE RELIEE AU MASQUE 22 ET CONCUE POUR QUE SON EXTREMITE LA PLUS ELOIGNEE SOIT RELIEE A UNE SOURCE A VIDE 30 POUR EVACUER LES GAZ PROVENANT DU MASQUE QUAND LE PATIENT EXHALE. UN RESERVOIR FERME 26 EST MONTE EN SERIE AVEC LADITE LIGNE D'ECHAPPEMENT ENTRE SES EXTREMITES LA PLUS PROCHE ET LA PLUS ELOIGNEE. LE RESERVOIR 26 COMPREND UNE ENTREE ET UNE SORTIE AVEC UNE VALVE D'ARRET 78 DANS UNE POSITION ADJACENTE A L'ENTREE POUR EVITER AU COURANT GAZEUX DE SORTIR DU RESERVOIR PAR L'ENTREE QUAND LE PATIENT INHALE. AVANTAGEUSEMENT, LA VALVE D'ARRET 78 DU RESERVOIR EST UNE VALVE A DIAPHRAGME ET LE MASQUE FACIAL COMPREND AU MOINS UNE BUSE 36 OU 38 POUR COLLECTER LES GAZ S'ECHAPPANT DU MASQUE. THE INVENTION RELATES TO A DEVICE FOR DELIVERING ANESTHESIC GAS TO A PATIENT, INCLUDING A MASK 22, MEANS FOR PROVIDING AN ANESTHETIC GAS TO THE MASK WHEN THE INHAL PATIENT AND AN EXHAUST LINE 24, 28 HAVING ITS MOST EXTREMITY END CLOSE CONNECTED TO MASK 22 AND DESIGNED FOR ITS FURTHER END TO BE CONNECTED TO A VACUUM SOURCE 30 TO DISCHARGE GASES FROM THE MASK WHEN THE PATIENT EXHALS. A CLOSED RESERVOIR 26 IS MOUNTED IN SERIES WITH THE SAID EXHAUST LINE BETWEEN ITS NEAREST AND MOST FAR END. TANK 26 INCLUDES AN ENTRY AND AN OUTPUT WITH A STOP VALVE 78 IN A POSITION ADJACENT TO THE ENTRY TO AVOID GAS CURRENT FROM THE TANK FROM THE ENTRY WHEN THE PATIENT IS INHALED. ADVANTAGEUSLY, THE TANK VALVE 78 OF THE TANK IS A DIAPHRAGM VALVE AND THE FACE MASK INCLUDES AT LEAST ONE NOZZLE 36 OR 38 FOR COLLECTING THE GAS ESCAPING FROM THE MASK.

Automatically switching different aspiration levels and/or pumps to an ocular probe

A system for removing material from within an eye includes a probe having a distal tip insertable into the eye, the tip including an aspiration port, and a console coupled to the port along an aspiration pathway. The console includes a processor and a pump system that includes a first pump and a second pump, for providing a base level aspiration flow via the first pump by applying a base aspiration pressure differential and an additive level flow via the second pump, during the base level flow. The processor is configured to detect occlusion of the aspiration flow pathway by detecting an increased pressure differential above the base pressure.

Method of recovering pyridine in the solvent refining of oils

Multiple height fluid mixer and method of use

A mixer assembly (204, 603) for mixing intake air from an intake system (124) with exhaust gas from an exhaust gas recirculation system (134) to yield a mixture stream includes an intake air conduit (202, 700) having an inlet (206, 706) fluidly connected to the intake system. The mixer assembly (204, 603) also includes a mixer (200, 600) having an inlet (208, 702) fluidly connected to the exhaust gas recirculation system (134). The mixer (200, 600) is at least partially disposed in the intake air conduit (202, 700) and includes an outer pipe (203, 604) and a dividing portion (217, 602) disposed within the outer pipe. The dividing portion (217, 602) divides a first passage (216, 612) from at least one second passage (218, 608), the first passage having an outlet (216', 612') that is at a first height, and the second passage having an outlet ( 218', 608') that is at a second height.

Vacuum sense control for phaco pulse shaping

A method and apparatus for precisely controlling particle movement relative to a phacoemulsification needle tip is provided. The design monitors actual vacuum present and calculates a pulse shape amplitude waveform proportional to the amount of measured vacuum. An increase in vacuum indicates that the handpiece/needle is becoming occluded by a large particle. The present design determines whether additional power is required to bump or move a large particle away from the needle tip. The present design may employ a control loop that senses and continuously monitors vacuum. The design may dynamically vary the amount of ultrasonic energy delivered to the surgical area in response to the observed actual vacuum, and can actively vary the amount of power delivered to the surgical area based on the size of the particle and the resultant vacuum realized.

Anti-first-pass effect compounds

Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first-pass effect.

Method of recovering energy and chemicals from black liquor

A method and apparatus for treating black liquor generated in a sulfate pulping process to recover energy and chemicals therefrom includes heating (4) the black liquor (2) at a temperature and for a time period to produce substantial volumes of off gases (7) containing organic sulfur compounds; generating hydrogen sulfide (9) and preferably methane from the off gases; and utilizing the generated hydrogen sulfide in the sulfate pulping process. The hydrogen sulfide can be absorbed (13) into white liquor (15) to selectively control the sulfur content of the white liquor. The methane (31) is used as fuel in a lime reburning kiln (16).

Thermal isolation system in an analytical instrument

Sample analysis in a portable analytical instrument, preferably in the form of a gas chromatograph, benefits from temperature control of one or more thermal zones in the instrument by way of a thermal isolation system that includes a novel pumping assembly to effect a selective amount of thermal isolation of the thermal zone. The pumping assembly includes a pumping element in the form of a tubular or planar palladium structure. The pumping assembly makes use of the unique properties of palladium to allow selective control of a nominal gas pressure within a vacuum cavity. A component system, which may include a separation column and a thermal device for heating and/or cooling the component system, may be provided within the vacuum cavity. The thermal device and the pumping assembly are individually controlled by a control system. The pumping assembly may be operated to allow selective control of the thermal isolation of the thermal zone; alternatively, the component system may be subject to a controlled temperature by operating the thermal device. A sample mixture passing through the separation column may thereby be exposed to a desired temperature profile according to a selected program so that the sample will separate into its components for subsequent detection by a detector.

Sheet material of fibre-reinforced cement

ABSTRACT OF THE DISCLOSURE Sheet material, which may be flat or of profiled (e.g. corrugated) cross-section, suitable for use as building panels, e.g. roofing slates, is formed of a fibre reinforced cement composition comprising, in weight percentages:-Ordinary Portland cement 50 to 71% Pulverised fuel ash 14 to 40% Volatilised silica (containing at least 86% SiO2) 5 to 12% Filamentised chopped glass fibre strands 2 to 7% these components constituting at least 90% by weight of the composition, the material having a minimum average modulus of rupture of 16 N.mm-2 and a minimum density of 1.3 g.cm-3. The balance of the composition may include up to 4% by weight cellulose pulp and up to 5% of a plasticiser such as ball clay, bentonite or talc, together with small quantities of known dispersing agents and flocculating agents.

Automatically switching different aspiration levels and/or pumps to an ocular probe

Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification prober A first aspiration level, supplied by a-first pump,-roay-be- appl?ed-to the-probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Latchbolt for a door lock assembly

A latchbolt configured for use with a door lock assembly. The door lock assembly is configured for interaction with a strike coupled to a door frame, and operable to place the latchbolt in a locked configuration using the strike to generally prevent rotation of the door and an unlocked configuration to allow rotation of the door. The latchbolt includes a first member and a second member movably coupled to the first member. When the latchbolt is in the locked configuration the second member is movable relative to the first member from a first position to a second position in response to a predetermined force applied to the door.

Systems and methods for controlling vacuum within phacoemulsification systems

The invention relates to systems and methods for controlling vacuum within phacoemulsification systems. The phacoemulsification system may include a handpiece having a needle. The needle is coupled to a power source configured to cause the needle to be ultrasonically vibrated during operation and an aspiration source. The system further includes a footpedal that defines a first position and a second position. The system also includes a computer program product operatively coupled to the handpiece and the footpedal, the computer program product having a computer-usable medium having a sequence of instructions which, when executed by a processor, causes said processor to execute a process that controls power from the power source and vacuum from the aspiration source applied to the handpiece. The process includes the steps of providing a vacuum at a first level to the handpiece when the footpedal is at the first position; providing power to the handpiece when the footpedal is at the second position; and reducing the vacuum to a second level when the footpedal transitions from the first position to the second position.

Estimating remaining battery service life in an implantable medical device

Methods for estimating a remaining service life of an implantable medical device (IMD) battery are presented. In one embodiment, a characteristic discharge model of the battery is employed. Systems employing the methods may include an external device coupled to the IMD, for example, via a telemetry communications link, wherein a first portion of a computer readable medium included in the IMD is programmed to provide instructions for the measurement, or tracking, of time and the measurement of battery voltage, and a second portion of the computer readable medium included in the external device is programmed to provide instructions for carrying out the calculations when the voltage and time data is transferred via telemetry from the IMD to the external device.

Pest control and detection system with conductive bait matrix

A pest control and/or detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant and/or consumable and/or displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes a thermoplastic material and/or a resin.

Method and apparatus for effecting gas-liquid contact

Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. The same principle may be employed with other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases, for example, to treat or strip or react a component of the liquid phase. A gas-liquid contact apparatus, which may be a combined chemical reactor and solid product separation device, also is described. In order to effect efficient mass transfer and rapid reaction, gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear. To assist in the reaction, a surrounding shroud has a plurality of openings, generally of aspect ratio of approximately 1, of equal diameter and arranged in uniform pattern, such as to provide a gas flow therethrough less than about 0.02 lb/min/opening in the shroud. In general, the gas velocity index of gas through the openings in the shroud is at least about 18 per second per opening, preferably at least about 24 per second per opening. Each of the openings has an area corresponding to an equivalent diameter less than about one inch.

Stabilized bitumen compositions

Removal of hydrogen sulphide from gaseous streams

Hydrogen sulphide is removed from gas streams in rapid and efficient manner by oxidation to sulphur. The process is effected by intimately contacting the hydrogen sulphide in the gas stream with oxygen in an aqueous medium containing a hydrogen sulphide-oxidizing catalyst to effect oxidation of the hydrogen sulphide to sulphur, and transporting the sulphur particles to the surface of the aqueous medium. The sulphur particles collect on the surface of the aqueous medium and may be removed therefrom continuously or intermittently.

Combine-harvester with separating device operating on the principle of axial material flow

Sphingosine-1-phosphate receptor antagonists

This disclosure relates to sphingosine-1 -phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1 -phosphate 1(S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

Bridge apparatus and methods for coupling multiple non-fibre channel devices to a fibre channel arbitrated loop

Apparatus and methods for an enhanced bridge device for coupling multiple non-Fibre Channel storage devices to a Fibre Channel Arbitrated Loop (FC-AL) communication medium. Features and aspects hereof provide for FC-AL enhanced circuits (104, 202 .. 210) for processing loop port bypass (LPB) and loop port enable (LPE) primitive sequences addressed to any target arbitrated loop physical address (T-ALPA) associated with a storage device coupled with the bridge regardless of the present bypassed/non-bypassed status of other T-ALPAs processed by the bridge device and associated with other storage devices coupled with the bridge device.

Pacemaker telemetry system

An implantable medical device telemetry system provides a means for decoding telemetry downlink information transmitted from an external unit to an implanted medical device, and for encoding telemetry uplink signals to be transmitted from the implanted device to the external unit. A novel system architecture results in a very small telemetry subsystem in the implanted device and a very flexible system adaptable to be used in conjunction with various telemetry formats of various implanted devices. A programmable logic array (PLA) structure that is mask programmable and which may further be partially RAM programmable serves as the basis of the telemetry subsystem For downlink telemetry, a counter is enabled during intevals of interest in the downlink RF burst stream. The counter value at the end of such an interval is then applied to the variable inputs of the PLA for decoding in accordance with a selected telemetry protocol. For uplink telemetry, the counter and PLA is used to control transmission of uplink telemetry pulses, such that pulses are pulse-position modulated in accordance with data to be transmitted. Various different telemetry protocols may be supported by the same telemetry circuit, which may be mask-masked at the time of manufacture to be compatible with one or more different telemetry protocols.

Stabilized ophthalmic galactomannan formulations

Apparatus and method for separating blood samples

Apparatus and method for separating blood samples

Red cells are separated from plasma or serum of whole blood by arranging an evacuated tube (2) sealed by a self-sealing stopper (26) above and preferably coaxial with a tube (4) containing a blood sample and sealed by a self-sealing stopper (28). A hollow double ended needle (14) is held by a fixture (6) and is disposed between and coaxial with the tubes (2, 4) and the tubes are placed in the fixture (6) in a vertical position in a centrifuge (84) and rotated about and spaced from an axis parallel to the axis of the tubes and needle. After the red cells are separated from the serum and/or plasma, the tubes (2, 4) are pushed toward one another so that the needle (14) penetrates both stoppers and the serum and/or plasma is drawn into the upper tube (2). The tubes (2, 4) and needle (14) are separated while still being rotated so that the whole blood components are separated as required.

Radio communication system using synchronous frequency hopping transmissions

A frequency-hopping radio communication system is disclosed comprising a control unit which transmits to and receives from each of a plurality of slave stations using a frequency-hopping mode of operation. During a start-up mode, the control unit communicates a starting message to each slave station using a predefined frequency. The message identifies to each slave station a frequency-hopping sequence to be used to select the frequencies from a group of frequencies for transmission to and reception from the control unit. This message also specifies to each slave station unique starting frequencies in the frequency-hopping sequence at which to begin transmitting and receiving. All slave station transmissions are synchronized to the control unit transmissions, thereby preventing any two stations from concurrently using the same frequencies for either transmitting to or receiving from the control unit.

Inhibitors of the hedgehog pathway

The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Systems and methods for controlling vacuum within phacoemulsification systems

Systems and methods for controlling vacuum within phacoemulsification systems are described. The phacoemulsification system may include a handpiece having a needle coupled to a power source configured to cause the needle to be ultrasonically vibrated, and an aspiration source. The system further includes a footpedal that defines a first position and a second position and a computer program product, operatively coupled to the handpiece and the footpedal, having a non-transitory computer-usable medium having a sequence of instructions which, when executed by a processor, causes the processor to execute a process that controls power from the power source and vacuum from the aspiration source applied to the handpiece.

Apparatus for loading and verifying a control store memory of a central subsystem

A central subsystem of a data processing system includes a writable control store which is loaded with firmware to control the central subsystem operations. The central subsystem logic is responsive to a sequence of commands from a system management facility to load the control store and verify that the control store firmware is loaded correctly.

Optimization of contact lenses to reduce aberrations and methods for their design

The invention provides lenses that are designed by taking into account one or more of pupil size, field, and decentration.

Aqueous cleaning method

A machine for removing oil, dirt and grinding debris from a metal surface comprises a plurality of wash, rinse and dry stations separated to prevent contamination carryover from one station to the next. Razor blades in stacks are passed through the stations, the stacked blades being mounted on rods supported by a fixture and the nozzles or jets within the machine being so oriented as to cause a riffling of the blades due to water or air pressure. A purified water rinse and preferably an aqueous cleaning solution are employed in the machine and are circulated through the stations by a flow system which provides efficient and economical usage of the cleaning solution and rinse materials.

Implantable centrifugal blood pump with hybrid magnetic bearings

A pump for pumping sensitive fluids, such as blood, has no mechanical contact between the impeller and any other structure.

Pyrimidine Derivatives As Kinase Modulators and Method of Use

The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR 1 R 1a , or O—R 1 , wherein X is H, halo, C 1 -C 6 alkyl, NO 2 , mono-, di-, or tri-halo substituted methyl, NR 13 R, 14 . C(O)O—C 1 -C 6 alkyl, or N(R 13 )—C(O)—C 1 -C 6 alkyl; Y is H, halo, OH, C 1 -C 6 alkyl, C 0 -C 6 alkyl-NR, 15 R 16 , NR 15 R, 6 , C 1 -C 6 alkoxy, —N(R 13 )—(CH 2 ) n- NR 15 R 16 , —C(O)O—C 1 -C 6 alkyl, —O—(CH 2 ) n —NR 15 R 16 , —C(O)—C 1 -C 6 alkyl, —C 0 -C 6 -alkyl-R 21 , —O—R 21 , —C(O)—R 21 , —O—(CH 2 ) n —R 21 , —C(O)—NR 13 R 14 , —C(O)—N(R 13 )-aryl, —C(O)—N(R 13 )(CH 2 ) n —NR 15 R 16 , —C(O)—N(R 13 )—(CH 2 ) n -aryl —C(O)—N(R 13 )—(CH 2 ) n -heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S. Z is H, NR 2 R 3 , —S—R 2a , or —O—R 2a

Counter control

Sterile aqueous ophthalmic composition comprising a block copolymer of ethylene oxide butylene oxide (eo-bo) and a galactomannan; and use for the treatment of dry eye.

Composición oftálmica acuosa estéril que comprende un copolímero de bloque de óxido de etileno óxido de butileno (EO-BO) y una galactomanana; composición farmacéutica que comprende uno o más agentes farmacéuticamente activos seleccionados entre antiglaucomatosos, anti-infecciosos, antiinflamatorios, antialérgicos. Sterile aqueous ophthalmic composition comprising an ethylene oxide butylene oxide (EO-BO) block copolymer and a galactomannan; pharmaceutical composition comprising one or more pharmaceutically active agents selected from antiglaucoma, anti-infective, anti-inflammatory, antiallergic agents.