14-01-2021 дата публикации
Номер: US20210009597A1
Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: 2. The compound of claim 1 , or a tautomer claim 1 , stereoisomer claim 1 , isotopologue claim 1 , or salt thereof claim 1 , wherein G is N(R)(R) claim 1 , in which each of Rand R claim 1 , independently claim 1 , is Calkyl claim 1 , Ccycloalkyl claim 1 , Cheterocyclyl claim 1 , aryl claim 1 , or heteroaryl claim 1 , or claim 1 , Rand R claim 1 , together with the atom to which they are attached claim 1 , form Cheterocyclyl.3. The compound of claim 1 , or a tautomer claim 1 , stereoisomer claim 1 , isotopologue claim 1 , or salt thereof claim 1 , wherein L is O.4. The compound of claim 2 , or a tautomer claim 2 , stereoisomer claim 2 , isotopologue claim 2 , or salt thereof claim 2 , wherein G is N(R)(R) or Cheterocyclyl.5. The compound of claim 4 , or a tautomer claim 4 , stereoisomer claim 4 , isotopologue claim 4 , or salt thereof claim 4 , wherein G is Cheterocyclyl.6. The compound of claim 5 , or a tautomer claim 5 , stereoisomer claim 5 , isotopologue claim 5 , or salt thereof claim 5 , wherein the Cheterocyclyl is a 5- or 6-membered ring.8. The compound of claim 7 , or a tautomer claim 7 , stereoisomer claim 7 , isotopologue claim 7 , or salt thereof claim 7 , wherein Y is —NR claim 7 , R being H or Calkyl; or Y is —CR′R″ claim 7 , each of R′ and R″ claim 7 , independently claim 7 , being H claim 7 , OH claim 7 , NH claim 7 , or Calkyl.10. The compound according to selected from2,5-difluoro-N-(4-(4-(2-methoxyethoxy)-2-((4-((4-methylpiperazin-1-yl)methyl) phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl) phenyl)benzenesulfonamide;2,5-difluoro-N-(4-(4-methoxy-2-((4-((4-methyl piperidin-1-yl) methyl)phenyl)amino)-7H-pyrrolo[2,3-d] pyrimidin-5-yl) phenyl)benzenesulfonamide;2,5-difluoro-N-(4-(4-(2-methoxyethoxy)-2-((4-((4-methylpiperidin-1-yl)methyl) phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl) phenyl)benzenesulfonamide;N-(4-(4 ...
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