13-09-2012 дата публикации
Номер: US20120231035A1
Принадлежит:
The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. 173-. (canceled)74. A method for preventing onset of a cancerous condition in a subject comprising administering to said subject an amount of an expression vector which comprises a nucleic acid molecule consisting of a nucleotide sequence which encodes a part of the protein encoded by the nucleotide sequence of SEQ ID NO: 1 operably linked to a promoter , in an amount sufficient to prevent onset of said cancerous condition in said subject.75. The method of claim 74 , wherein said part of a protein binds to an MHC Class I molecule.76. The method of claim 74 , wherein said part of a protein binds to an MHC Class II molecule.77. The method of claim 76 , wherein said part of a protein consists of no more than 25 amino acids.78. The method of claim 74 , wherein said expression vector is adenovirus based.79. The method of claim 74 , wherein said cancerous condition is melanoma. This application is a divisional of application Ser. No. 12/930,522 filed Jan. 10, 2011, which is a divisional of application Ser. No. 11/499,547 filed Aug. 4, 2006, which is a divisional of application Ser. No. 10/751,088 filed Jan. 4, 2002, now U.S. Pat. No. 7,115,729 and is a continuation in part of application Ser. No. 09/062,422, filed Apr. 17, 1998, now U.S. Pat. No. 6,252,052, which is a continuation-in-part of application Ser. No. 08/937,263, filed Sep. 15, 1997, now U.S. Pat. No. 6,274,145, which is a continuation-in-part of application Ser. No. 08/725,182, filed Oct. 3, 1996 now U.S. Pat. No. 5,804,381. All of these applications are incorporation by reference.This invention relates to HLA binding peptides derived from 10 an antigen associated with cancer. These peptides bind to Class I and to Class II MHC molecules.It is fairly well established that many pathological conditions, such as infections, cancer, autoimmune ...
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