Novel method for synthesizing bi-axungia acyl-phosphatidylethanolamine

The present invention relates to a novel method for preparing di-fatty acyl phosphatidylethanolamine as an accessory used in the technology of lipidosomes. In the preparation method, di-fatty acyl glyceride is used as starting material, which is finally reacted with phosphorus oxychloride and neovaricaine to produce the compound, di-fatty acyl phosphatidylethanolamine.

Novel dispersed system with docetaxel as main component

The invention relates to a dispersion system with docetaxel as main component for injection, comprising a surfactant, an assistant surfactant and a specified amount of oil for injection. The volume ratio of oil phase to the surfactant is greater than 3 percent as well as less than and equal to 33 percent. The volume ratio of the assistant surfactant to surfactant is greater than or equal to 12.5 percent and less than 167 percent.

Preparation of 1-(4-hydroxyphenyl)-2-bromopropan-1-one and application thereof

Preparation of ifenprodil bromo-intermediate 1-(4-oxyphenyl)-2-bromopropane-1-ketone and its use in preparation ifenprodil and its salt are disclosed. The process is carried out by taking 4-hydroxy-phenyl-ketone as initial material, taking copper bromide as bromo-reagent, bromo-reacting under organic solvent back flow, removing copper ion in mixed liquid, and condensing to obtain solid final product.

Refining method of 1-(4-hydroxylphengl)-2-bromopropane-1-ketone

The invention relates to a refining method of 1-(4-hydroxylphengl)-2-bromopropane-1-ketone, which is an ifenprodil bromo-intermediate. The refining method comprises the following steps of: dissolving a 1-(4-hydroxylphengl)-2-bromopropane-1-ketone crude product into ether, reversely dripping with a reversible solvent, such as petroleum ether, stirring at low speed to separate out white solid, and filtering to prepare the 1-(4-hydroxylphengl)-2-bromopropane-1-ketone pure product.

Novel method for synthesizing bi-axungia acyl-phosphatidylethanolamine

The present invention relates to a method for preparing di-fatty acyl phosphatidylethanolamine as an accessory used in the technology of lipidosomes. In the preparation method, di-fatty acyl glyceride is used as starting material, which is finally reacted with phosphorus oxychloride and neovaricaine to produce the compound, di-fatty acyl phosphatidylethanolamine.

Liposome medicament and preparation thereof

The invention relates to a liposome drug and a preparation method thereof, in particular to a mitoxantrone liposome preparation and the preparation method. The liposome drug is characterized in that the particle size of the liposome is 30 to 80nm, and the liposome drug contains: 1) the active ingredients are multivalent ion drugs, which can form the sediment which is difficult to dissolve along with the multivalent counter ions in the liposome; 2) phospholipid double molecular layers contain the phospholipid containing Tm which is higher than the body temperature and other excipients which can be taken as the liposome drugs.

Novel dispersed system with docetaxel as main component

The invention relates to a dispersion system with docetaxel as main component for injection, comprising a surfactant, an assistant surfactant and a specified amount of oil for injection. The volume ratio of oil phase to the surfactant is greater than 3 percent as well as less than and equal to 33 percent. The volume ratio of the assistant surfactant to surfactant is greater than or equal to 12.5 percent and less than 167 percent.

Medicinal preparations containing duloxetine hydrochloride and preparation method thereof

The invention relates to an enteric-coated tablet containing duloxetine hydrochloride and a preparation method thereof. The enteric-coated tablet of duloxetine hydrochloride consists of three parts: a tablet core, a gastric-coated isolation layer and an enteric-coated layer. The technical proposal of the invention can effectively avoid the cross reaction between the medicine and enteric coating material occurring during the releasing process of the medicine and affecting the release of the medicine; therefore, the stability of the medicine can be effectively improved. The preparation method is simple and is easy to be operated, which is suitable for industrialized production.

Butylphthalide dripping pill and preparing method

Anti-fatigue anti-hypoxia health food composition

The invention relates to a Glycine health food compound, which mainly comprises 45%-80% of D-ribose, 15%-50% of L-carnitine and 0.5%-8% of Sacarina, wherein, the Sacarina is chosen from Aspartan, stevioside, egg white and sugar, Sadium Cyclamate, sugar elements, xylitol, mannite, citric acid, strawberry essence, orange flavor, peach flavor, green apple flavor, flavoring pineapple essence, watermelon essence, erythritol, etc. The compound has the health-care functions of anti-fatigue and oxygen-poor resistance.

Wind-generated electricity construction equipment of seaborne intertidal zone

The invention discloses a wind-generated electricity construction equipment of a seaborne intertidal zone and relates to the civil engineering industry of construction industry. A main lifter (2) and an auxiliary lifter (3) are arranged above a first boat body (1) respectively; the auxiliary lifter (3) assists the main lifter (2) in operation; an overhanging platform (5), a piling machine (6) and a crane (7) are arranged on a second boat body (4) respectively; a mooring rope storing disc (9), an untwisting frame (10), a steering frame (11) and a tractor (12) are arranged on a third boat body (8) respectively; the mooring rope storing disc (9) is arranged on the left side of the untwisting frame (10); the steering frame (11) is arranged on the right side of the untwisting frame (10); and the tractor (12) is arranged on the right side of the steering frame (11). The problem on piling in the intertidal zone, the problem on the construction safety of the neaped state of a piling boat and the ...

Preparation of 1-(4-hydroxyphenyl)-2-bromopropan-1-one and application thereof

Preparation of ifenprodil bromo-intermediate 1-(4-oxyphenyl)-2-bromopropane-1-ketone and its use in preparation ifenprodil and its salt are disclosed. The process is carried out by taking 4-hydroxy-phenyl-ketone as initial material, taking copper bromide as bromo-reagent, bromo-reacting under organic solvent back flow, removing copper ion in mixed liquid, and condensing to obtain solid final product.

Medicinal preparations containing duloxetine hydrochloride and preparation method thereof

The invention relates to an enteric-coated tablet containing duloxetine hydrochloride and a preparation method thereof. The enteric-coated tablet of duloxetine hydrochloride consists of three parts: a tablet core, a gastric-coated isolation layer and an enteric-coated layer. The technical proposal of the invention can effectively avoid the cross reaction between the medicine and enteric coating material occurring during the releasing process of the medicine and affecting the release of the medicine; therefore, the stability of the medicine can be effectively improved. The preparation method is simple and is easy to be operated, which is suitable for industrialized production.

Liposome medicament and preparation thereof

The invention relates to a liposome drug and a preparation method thereof, in particular to a mitoxantrone liposome preparation and the preparation method. The liposome drug is characterized in that the particle size of the liposome is 30 to 80nm, and the liposome drug contains: 1) the active ingredients are multivalent ion drugs, which can form the sediment which is difficult to dissolve along with the multivalent counter ions in the liposome; 2) phospholipid double molecular layers contain the phospholipid containing Tm which is higher than the body temperature and other excipients which can be taken as the liposome drugs.

Method for synthesizing ifenprodil tartrate

Preparation of tartaric acid ifenprodil is carried out by 4-hydroxy-phenpropionate as initial raw material, reacting with copper bromide to remove copper ion, preparing into intermediate 1-(4-oxyphenyl)-2-bromopropane-1-ketone, condensation reacting with 4-benzyl pyridine to obtain intermediate, hydrogenation reducing intermediate 1-(4-hydroxy-phenyl)-2-(4-benzyl pyridine) propane-1-keto-hydro-bromic acid salt to obtain ifenprodil, and salting with tartaric acid to obtain final product.

Method for synthesizing ifenprodil tartrate

Preparation of tartaric acid ifenprodil is carried out by 4-hydroxy-phenpropionate as initial raw material, reacting with copper bromide to remove copper ion, preparing into intermediate 1-(4-oxyphenyl)-2-bromopropane-1-ketone, condensation reacting with 4-benzyl pyridine to obtain intermediate, hydrogenation reducing intermediate 1-(4-hydroxy-phenyl)-2-(4-benzyl pyridine) propane-1-keto-hydro-bromic acid salt to obtain ifenprodil, and salting with tartaric acid to obtain final product.

Refining method of 1-(4-hydroxylphengl)-2-bromopropane-1-ketone

The invention relates to a refining method of 1-(4-hydroxylphengl)-2-bromopropane-1-ketone, which is an ifenprodil bromo-intermediate. The refining method comprises the following steps of: dissolving a 1-(4-hydroxylphengl)-2-bromopropane-1-ketone crude product into ether, reversely dripping with a reversible solvent, such as petroleum ether, stirring at low speed to separate out white solid, and filtering to prepare the 1-(4-hydroxylphengl)-2-bromopropane-1-ketone pure product.