INHIBITORS OF PEPTID DEFORMYLASE

PEPTID DEFORMYLASE HEMMER

METHOD FOR THE TREATMENT OF THE CHRONIC OBSTRUCTIVE ONES BRONCHOPNEUMOPATHIE

PROCEDURE FOR THE IDENTIFICATION OF A PDE IV HEMMERS

PEPTIDE DEFORMYLASE INHIBITORS

PEPTIDE DEFORMYLASE INHIBITORS

CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY

... 2120351 9307111 PCTABS00021 Compounds illustrated by general formula (I) useful as PDE IV inhibitors and for inhibiting the production of Tumor Necrosis Factor (TNF) are disclosed herein. In formula (I) R1 is C1-12 alkyl unsubstituted or substituted by 1 or more halogens; C3-6 cyclic alkyl unsubstituted or substituted by 1 to 3 methyl groups or one ethyl group; C4-6 cycloalkyl containing one or two unsaturated bonds; C7-11 polycycloalkyl, -(CR14R14)nC(O)-O-(CR14R14)m-R10, -(CR14R14)nC(O)-O-(CR14R14)r-R11, -(CR14R14)xOH, -(CR14R14)sO(CR14R14)m-R10, -(CR14R14)sO(CR14R14)r-R11, -(CR14R14)n-(C(O)NR14)-(CR14R14)m-R10, -(CR14R14)n-(C(O)NR14)-(CR14R14)r-R11, -(CR14R14)y-R11 or -(CR14R14)z-R10; X2 is O or NR14; X3 is hydrogen or X; X is YR2, halogen, nitro, NR14R14 or formamide; Y is O or S(O)m; R2 is -CH3 or -CH2CH3, each may be unsubstituted or substituted by 1 to 5 fluorines; A is (a), (b), (c), (d) or (e); B is >C=Z or C=S.

MONOMERS OF THE 4,4 (DISUBSTITUIERTEN) CYCLOHEXAN-1 OLE AND USED CONNECTIONS

CONNECTIONS TO THE TREATMENT OF ALLERGI AND INFLAMMATORY ILLNESSES

DERIVATIVES OF PHENYL-CYCLOALKANES AND CYCLOALKENEDERIVATIVES OF PHENYL-CYCLOALKANES AND CYCLOALKENES S

A compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is -CH3 or -CH2CH3 unsubstituted or substituted by 1 to 3 fluorines; X is O or S(O)s where s = 0 to 2; R2 is C4-C6 cyclic alkyl, optionally substituted by one to three methyl groups or one ethyl group; -CH2-cyclopentyl, -CH2-cyclopropyl, 3-tetrahydrofuranyl, C1-7 alkyl, CH3 or CH2CH3 substituted by one to three fluorines; -(CH2)nCOO(CH2)gCH3, or (CH2)nO(CH2)gCH3, wherein n is 2 to 4 and g is 0 to 2; R3 represents a moiety of formula (a) wherein R4 and R5 each represent hydrogen or R4 and R5 together represent a bond; B represents >C=O, >C=S or >CH-R6 wherein R6 represents H, OH, C1-6 alkoxy or C1-6 thioalkoxy; and m and r each independently represents zero or an integer in the range of 1 to 4 wherein m+r represents an integer in the range of from 2 to 4; with the proviso that when R1 is methyl, X is oxygen, R2 is methyl or cyclopenyl, R3 does not represent cyclopent-1,2-ene-3-one.

4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS

The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

PEPTIDDEFORMYLASE HEMMER

PEPTIDE DEFORMYLASE INHIBITORS

TNF INHIBITORS

Derivatives of 2-pyrrolidinones are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production.

COMPOUNDS USEFUL FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES

... 2133439 9319749 PCTABS00027 Novel compounds of formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.

Peptide deformylase inhibitors

COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES

... 2133337 9319750 PCTABS00027 Novel cyclohexanes of formulas (I) and (II) are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV.

METHOD FOR TREATING MULTIPLE SCLEROSIS

A method for treating multiple sclerosis comprising administering compounds of Formula (I) where X4 is a 1-substituted cyclohexyl group and the other groups are ethers or thioethers or a compound of Formula (II) where W is an aliphatic group of 2 to 6 carbons and R3 is an acid, amide or aromatic or heteroaromatic group and Z is exemplified by an alcohol or alcohol derivative.

Peptide deformylase inhibitors

PEPTIDE DEFORMYLASE INHIBITORS

OXAMIDES

... 2086741 9200968 PCTABS00010 Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby.

IMIDAZOLIDINONE COMPOUNDS

... 2095429 9207567 PCTABS00013 Novel imidazolidinone derivatives are described which inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease stated mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.

4.4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS-MONOMERS AND RELATED COMPOUNDS

The present invention relates to novel 4.4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Fatty acid synthase inhibitors

3,3-(DISUBSTITUTED)CYCLOHEXAN-1-OL MONOMERS AND RELATED COMPOUNDS

The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

PYRROLIDINONES

... 2102106 9219594 PCTABS00017 Novel pyrrolidinones are described which inhibit PDE IV and TNF.

Peptide deformylase inhibitors

Peptide deformylase inhibitors

METHOD FOR TREATING COPD

A method for treating COPD comprising administering compounds of Formula (I) where X4 is a 1-substituted cyclohexyl group.

4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE MONOMERS AND RELATED COMPOUNDS

This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

Verfahren zur Identifizierung eines PDE IV Hemmers

Peptide deformylase inhibitors

PDF inhibitors and novel methods for their use are provided.

Compounds

PEPTIDE DEFORMYLASE INHIBITORS

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Substituted-pent-4-ynoic acids

Verfahren zur Identifizierung eines PDE IV Hemmers

Peptide deformylase inhibitors

Compounds

This invention relates to a method for selecting PDE IV inhibitors which have a salutory therapeutic index, and to compounds having these properties.

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

Pyrazolo[3,4-B]Pyridine Compound, and Its Use as a Pde4 Inhibitor

The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, which is the compound of formula (I): or a salt thereof.

INHIBITORS OF THE DEFORMILASE PEPTIDE.

Un compuesto de acuerdo con la Fórmula (1): en la que: X se selecciona entre el grupo que consiste en CH2, NR2, O, NR2CO, 5 CONR2 y un enlace; Y representa O, CH2 o un enlace: Z representa H o F; R se selecciona entre el grupo que consiste en: alquilo C2-6 opcionalmente sustituido con alcoxi, halógeno, o alquilsulfanilo C1-3; alquenilo C2-6 opcionalmente sustituido con alcoxi, halógeno, o alquilsulfanilo C1-3; alquinilo C2-6 opcionalmente sustituido con alcoxi, halógeno, o alquilsulfanilo C1-3; carbociclo (CH2)n-C3-6 opcionalmente sustituido con alcoxi, halógeno, o alquilsulfanilo C1-3; (CH2)n-R3 {en la que R3 es fenilo, furano, benzofurano, tiofeno, benzotiofeno, tetrahidrofurano, tetrahidropirano, dioxano, 1,4-benzodioxano o benzo[1,3]dioxol; R3 está opcionalmente sustituido con uno o más Cl, Br, I, alquilo C1-3 opcionalmente sustituido con uno a tres F, o C1-2 alcoxi, opcionalmente sustituido con uno a tres F}; R1 se selecciona entre el grupo que consiste en: hidrógeno, alquilo C1-3 sustituido, alquenilo C2-3 sustituido, alquinilo C2-3 sustituido, carbociclo (CH2)n-C3-6 sustituido, arilo, heteroarilo, heterocíclico, y aminocarbonilo siempre que X sea (CH2)n cuando R1 representa aminocarbonilo; R2 representa: hidrógeno, o alquilo C1-3 sustituido; X representa (CH2)n, NR2, O, NR2CO, CONR2 o un enlace; Y representa O, CH2 o un enlace covalente; Z representa hidrógeno o flúor; preferentemente flúor; y n representa un entero entre 0 y 2 o una sal, solvato o derivado fisiológicamente funcional del mismo. A compound according to Formula (1): in which: X is selected from the group consisting of CH2, NR2, O, NR2CO, CONR2 and a bond; Y represents O, CH2 or a bond: Z represents H or F; R is selected from the group consisting of: C2-6 alkyl optionally substituted with alkoxy, halogen, or C1-3 alkylsulfanyl; C2-6 alkenyl optionally substituted with alkoxy, halogen, or C1-3 alkylsulfanyl; C2-6 alkynyl optionally substituted with alkoxy, halogen, or C1-3 alkylsulfanyl; ...

1,4-substituted 4,4-diaryl cyclohexanes

This invention relates to compounds of Formula (I) where Z is an amine, alcohol or derivative thereof, and the ketone analog thereof.

4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds

The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Method for treating copd

Peptide deformylase inhibitors

Peptide deformylase inhibitors.

Method for treating copd

This invention relates to a method for the prophylaxis of or for treating COPD by administering a PDE4 inhibitor which has a defi ned therapeutic ratio.

Compounds useful for treating allergic and inflammatory diseases

Novel compounds of Formula (I) ##STR1## where X 4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.

Peptide deformylase inhibitors

PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

4,4-(disubstituted)cyclohexan-1-ylidine acetate dimers and related compounds

The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ylidine acetate dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

INHIBITORS OF DEFORMILASE OF PEPTIDES.

Uso de un compuesto de Fórmula (I) en donde: X=O; Ar1 es opcionalmente fenilo sustituido en donde el sustituyente es, independientemente, uno, dos o tres sustituyentes seleccionados entre el grupo consistente en alquilo o cicloalquilo no sustituidos con uno a nueve átomos de carbono, halógeno, alcoxi que tiene de uno a nueve átomos de carbono, hidroxi, hidroxialquilo que tiene de uno a nueve átomos de carbono, alcoxialquilo, en donde los grupos alquilo y alquileno tienen independientemente de uno a nueve átomos de carbono; Y se selecciona entre el grupo consistente en un enlace covalente, oxígeno, alquileno con dos a cuatro átomos de carbono, alquenileno con dos átomos de carbono, alquinileno con dos átomos de carbono, S(O)p, C(O), en donde p es 0-2; Ar2 es un grupo arilo seleccionado entre el grupo consistente en fenilo, piridilo, pirazinilo, piridazinilo, furilo tienilo, isoxazolilo, oxazolilo, tiazolilo e isotiazolilo; de modo que Ar2 puede estar opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados entre el grupo consistente en alquilo o cicloalquilo no sustituidos con uno a nueve átomos de carbono, halógeno, alcoxi con uno a nueve átomos de carbono, hidroxi, hidroxialquilo con uno a nueve átomos de carbono, alcoxialquilo, en donde los grupos alquilo y alquileno tienen independientemente uno a nueve átomos de carbono; y ciano, o sus sales o complejos farmacéuticamente aceptables, en la preparación de un medicamento para uso en el tratamiento de infecciones bacterianas. Use of a compound of Formula (I) where: X = O; Ar1 is optionally substituted phenyl wherein the substituent is independently one, two or three substituents selected from the group consisting of alkyl or cycloalkyl unsubstituted with one to nine carbon atoms, halogen, alkoxy having one to nine carbon atoms , hydroxy, hydroxyalkyl having one to nine carbon atoms, alkoxyalkyl, wherein the alkyl and alkylene groups independently have one to nine carbon atoms; And it is selected from ...

Peptide deformylase inhibitors

PDF inhibitors and novel methods for their use are provided.

Peptide-deformylase inhibitors

Nobel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

4,4-(disubstituted)cyclohexan-1-one monomers and related compounds

Peptide deformylase inhibitors

1,3,3-(trisubstituted)cyclohexane dimers and related compounds

This invention relates to certain 1,3,3-(trisubstituted)cyclohexane dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

1,4,4-(trisubstituted)cyclohexane monomers and related compounds

This invention relates to certain 1,4,4-(trisubstituted)cyclohexane monomers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Fatty acid synthase inhibitors

Peptide deformylase inhibitors

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

METHOD FOR TREATMENT OF THE DPCO

4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds

The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

INHIBITORS OF THE PEPTIDE DESFORMILASA.

Un compuesto de acuerdo con la fórmula (I) o una sal suya farmacéuticamente aceptable en la que: R1 se selecciona del grupo formado por alquilo C1-6, alquil-C1-2-Ar y Ar; R2 se selecciona del grupo formado por hidrógeno, alquilo C1-6, -(CH2)mOH, -(CH2)nAr'', -(CH2)nHet, -Ar'', - SO2R3, -C(O)R3, -C(O)NHR3, -C(O)OR3, -CH(R4)CONR5R6 y - CH(R4)CO2R7; R3 se selecciona del grupo formado por alquilo C1-6, alquil-C1-2-Ar'' y Ar''; R4 es hidrógeno o alquilo C1-6; R5 y R6 se seleccionan independientemente del grupo formado por hidrógeno, alquilo C1-6, alquil-C1-2-Ar'' y Ar''; o R5 y R6 forman juntos un anillo cicloalquílico de cinco o seis miembros que opcionalmente está monosustituido con - CH2OR7; R7 se selecciona del grupo formado por hidrógeno y alquilo C1-3; Ar se selecciona del grupo formado por fenilo, furilo y tienilo, que pueden estar sustituidos todos ellos opcionalmente con uno o más grupos Z1; Ar'' se selecciona del grupo formado por fenilo, naftilo, furilo, piridilo, tienilo, tiazolilo, isotiazolilo, pirazolilo, triazolilo, tetrazolilo, imidazolilo, imidazolidinilo, benzofuranilo, indolilo, tiazolidinilo, isoxazolilo, oxadiazolilo, tiadiazolilo, morfolinilo, piperidinilo, piperazinilo, pirrolilo y pirimidilo, que pueden estar sustituidos todos ellos opcionalmente con uno o más grupos Z2; Het se selecciona del grupo formado por tetrahidrofuranilo y piperidinilo; Z1 se selecciona independientemente del grupo formado por hidrógeno, alquilo C1-3, -CN, F, Cl, Br e I; Z2 se selecciona independientemente del grupo formado por hidrógeno, alquilo C1-6, alcoxi C1-6, -(CH2)nCO2R4, - C(O)NR5R6, -CN, -(CH2)nOH, -NO2, F, Cl, Br, I, -NR5R6 y - NHC(O)R1; m es 2 a 5; y n es 0 a 5. A compound according to formula (I) or a pharmaceutically acceptable salt thereof in which: R1 is selected from the group consisting of C1-6 alkyl, C1-2 alkyl-Ar and Ar; R2 is selected from the group consisting of hydrogen, C1-6 alkyl, - (CH2) mOH, ...

3,3-(disubstituted)cyclohexan-1-one monomers and related compounds

4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds.

La presente invencion se refiere a monomeros novedosos de 4,4-(disustituido)ciclohexan-1-oles y a compuestos relacionados; a composiciones farmacéuticas que contiene esos compuestos y a su uso en el tratamiento de enfermedades alérgicas e inflamatorias; y para inhibir la produccion del factor de necrosis tumoral (FNT).

4,4-(DISUBSTITUTED)CYCLOHEXAN-l-OLS MONOMERS AND RELATED COMPOUNDS

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Method for treating copd

This invention relates to a method for the prophylaxis of or for treating COPD by administering a PDE4 inhibitor which has a defi ned therapeutic ratio.

4,4-(disubstituted)cyclohexan-1-ol derivatives and pharmaceutical compositions containing them

1,4-Substituted 4,4-diaryl cyclohexanes.

Bulus Z'nin bir amin, alkol veya türevi oldugu Formül (I) bilesimleriyle ve keton analogu ile ilgilidir. It relates to compounds of Formula (I) wherein Bulus Z is an amine, alcohol or derivative, and ketone analog.

4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds

4,4-(disubstituted)cyclohexan-1-ol derivatives pharmaceutical compositions containing these compounds and use thereof

A cím szerinti vegyületek (I) általánős képletében R1 -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)rR6, -(CR4R5)nO(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6; m 0, 1 vagy 2; n 0, 1, 2, 3 vagy 4; r 0, 1,2, 3, 4, 5 vagy 6; R4 és R5 hidrőgénatőm vagy szénatőmős alkilcsőpőrt;R6 hidrőgénatőm, metil-, hidrőxi-, aril-, aril-őxi-alkil-, indanil-,indenil-, pőliciklőalkil-, tetrahidrőfűril-, fűril-,tetrahidrőpiranil-, piranil-, tetrahidrőtienil-, tienil-,tetrahidrőtiőpiranil-, tiő-piranil- és ciklőalkilcsőpőrt; azzal amegkötéssel, hőgy a) ha R6 hidrőxicsőpőrt, akkőr m 2; vagy b) ha R6hidrőxicsőpőrt, akkőr m 2, 3, 4, 5 vagy 6; vagy c) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr m 1 vagy 2; vagy d) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr r 1, 2, 3, 4, 5 vagy 6; vagy e) ha n1, és m 0, akkőr a -(CR4R5)nO(CR4R5)mR6 csőpőrtban R6 hidrőgénatőmtóleltérő; X -YR2, flűőratőm, -NR4R5 vagy főrmil-aminő-csőpőrt; Yőxigénatőm vagy S(O)m'; m' 0, 1 vagy 2; X2 őxigénatőm vagy NR8; X3hidrőgénatőm vagy X; R2 adőtt esetben szűbsztitűált metil- vagyetilcsőpőrt; s 0, 1, 2, 3 vagy 4; W alkil, alkenil- vagyalkinilcsőpőrt; és R3 -COOR14, -C(O)NR4R14 vagy R7; Z -OR14, -OR15, -SR14, -S(O)m'R7, -S(O)2NR10R14, -NR10R14, -NR14C(O)R9, -NR10C(Y')R14,-NR10C(O)OR7, -NR10C(Y')NR10R14, -NR10S(O)2NR10R14, -NR10C(NCN)NR10R14, -NR10S(O)2R7, -NR10C(CR4NO2)NR10R14, -NR10C(NCN)SR9, -NR10C(CR4NO2)SR9, -NR10C(NR10)NR10R14, -NR10C(O)C(O)NR10R14 vagy -NR10C(O)C(O)OR14; A vegyületek allergiás ésgyűlladásős betegségek kezelésére, valamint a tűmőr nekrózis faktőr(TNF) képződésének gátlására alkalmazhatók. ŕ In the general formula (I) of the title compounds, R1 - (CR4R5) nC (O) O (CR4R5) mR6, - (CR4R5) rR6, - (CR4R5) nO (CR4R5) mR6, - (CR4R5) nC (O) NR4 ( CR4R5) mR6; m is 0, 1 or 2; n 0, 1, 2, 3 or 4; r 0, 1,2, 3, 4, 5 or 6; R4 and R5 hydrogens or carbon black alkylpipes; R6 hydrogens, ...

3,3-(disubstituted)cyclohexan-1-ylidine acetate monomers and related compounds

The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ylidine acetate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

1,4-substituted 4,4-diaryl cyclohexanes

3,3-(disubstituted)cyclohexan-1-ylidine acetate monomers and related compounds

The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ylidine acetate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Peptide deformylase inhibitors

PDF inhibitors and novel methods for their use are provided.

PDE-IV inhibitors

This invention relates to a compound which selectively inhibits PDE IV and wherein the IC 50 value for the PDE IV catalytic form which binds rolipram with a high affinity is lower than the IC 50 value for the form which binds rolipram with a low affinity and to uses thereof in therapy.

4,4-(Diszubsztituált)-1-ciklohexanol-származékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk

A cím szerinti vegyületek (I) általánős képletében R1 -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)rR6, -(CR4R5)nO(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6; m 0, 1 vagy 2; n 0, 1, 2, 3 vagy 4; r 0, 1,2, 3, 4, 5 vagy 6; R4 és R5 hidrőgénatőm vagy szénatőmős alkilcsőpőrt;R6 hidrőgénatőm, metil-, hidrőxi-, aril-, aril-őxi-alkil-, indanil-,indenil-, pőliciklőalkil-, tetrahidrőfűril-, fűril-,tetrahidrőpiranil-, piranil-, tetrahidrőtienil-, tienil-,tetrahidrőtiőpiranil-, tiő-piranil- és ciklőalkilcsőpőrt; azzal amegkötéssel, hőgy a) ha R6 hidrőxicsőpőrt, akkőr m 2; vagy b) ha R6hidrőxicsőpőrt, akkőr m 2, 3, 4, 5 vagy 6; vagy c) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr m 1 vagy 2; vagy d) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr r 1, 2, 3, 4, 5 vagy 6; vagy e) ha n1, és m 0, akkőr a -(CR4R5)nO(CR4R5)mR6 csőpőrtban R6 hidrőgénatőmtóleltérő; X -YR2, flűőratőm, -NR4R5 vagy főrmil-aminő-csőpőrt; Yőxigénatőm vagy S(O)m'; m' 0, 1 vagy 2; X2 őxigénatőm vagy NR8; X3hidrőgénatőm vagy X; R2 adőtt esetben szűbsztitűált metil- vagyetilcsőpőrt; s 0, 1, 2, 3 vagy 4; W alkil, alkenil- vagyalkinilcsőpőrt; és R3 -COOR14, -C(O)NR4R14 vagy R7; Z -OR14, -OR15, -SR14, -S(O)m'R7, -S(O)2NR10R14, -NR10R14, -NR14C(O)R9, -NR10C(Y')R14,-NR10C(O)OR7, -NR10C(Y')NR10R14, -NR10S(O)2NR10R14, -NR10C(NCN)NR10R14, -NR10S(O)2R7, -NR10C(CR4NO2)NR10R14, -NR10C(NCN)SR9, -NR10C(CR4NO2)SR9, -NR10C(NR10)NR10R14, -NR10C(O)C(O)NR10R14 vagy -NR10C(O)C(O)OR14; A vegyületek allergiás ésgyűlladásős betegségek kezelésére, valamint a tűmőr nekrózis faktőr(TNF) képződésének gátlására alkalmazhatók. ŕ

Peptid-deformylase-hemmer

Monomere der 4,4-(disubstituierten)cyclohexan-1- ole und verwandte verbindungen

Peptide deformylase inhibitors

Novel PDF inhibitors and novel methods for their use are provided.

Inhibitoren von peptid deformylase

Verfahren zur identifizierung eines pde iv hemmers

Peptiddeformylase-hemmer

3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds

The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen

Methode zur behandlung der chronischen obstruktiven bronchopneumopathie

3,3-(disubstituoituja)sykloheksan-1-olimonomeerejä ja vastaavia yhdisteitä

Method for treating multiple sclerosis

A method for treating multiple sclerosis comprising administering compounds of Formula (I) where X4 is a 1-substituted cyclohexyl group and the other groups are ethers or thioethers or a compound of Formula (II) where W is an aliphatic group of 2 to 6 carbons and R3 is an acid, amide or aromatic or heteroaromatic group and Z is exemplified by an alcohol or alcohol derivative.

Fatty acid synthase inhibitors

This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.

Monomeros de 3,3- (disustitución) ciclohexan-1-ol and components related

3,3-(disubstituted) monomers of cyclohexan-1-ol and compounds showing affinity to them

Novel use of compounds for anti-pruritic activity