03-06-2021 дата публикации
Номер: US20210161836A1
This invention discloses methods and compositions for the treatment of demyelinating disorders. Specifically, the invention relates to the use guanabenz or guanabenz derivative for treating demyelinating disorders. 7. The method of any one of the - , wherein Rand Rare not hydrogen.8. The method of any one of the - , wherein Rand Rare halogen.10. The method of any one of the - , wherein the demyelinating disorder is multiple sclerosis.11. The method of any one of the - , wherein the demyelinating disorder is selected from the group consisting of: acute disseminated encephalomyelitis , periventricular leukomalacia , periventricular white matter injury , Tabes Dorsalis , Devic's disease , optic neuritis , progressive multifocal leukoencephalopathy , transverse myelitis , chronic inflammatory demyelinating polyneuropathy , anti-MAG peripheral neuropathy , adrenoleukodystrophy , adrenomyeloneuropathy , Guillain-Barré Syndrome , central pontine myelinolysis , diffuse white matter injury , inherited demyelinating diseases such as leukodystrophy , and Charcot Marie Tooth Disease.12. The method of - , a symptom of a demyelinating disorder is selected from the group consisting of: fatigue , somatosensory dysfunction , tingling , pain , numbness , balance problems , problems with walking , changes in vision , depression , emotional changes , mood swings , impaired cognition , muscle dysfunction , impaired muscle coordination , sexual impairment , speech impairment , swallowing impairment , bladder dysfunction , bowel dysfunction.13. The method of any one of the - , wherein about 1 mg to about 64 mg of the compound is administered to the subject.14. The method of any one of the - , wherein about 4 mg to about 20 mg of the compound is administered to the subject.15. The method of any one of the - , wherein the compound is administered orally.16. The method of claim 1 , wherein the neuronal cell is a neuron.17. The method of claim 4 , wherein administration of said compound ...
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