Implantable driver with non-invasive transmural powering device for cardiac assist and combined assist and support devices

The present invention an implantable, sub-cutaneous, bellows-like device with one plate proximal (or superficial) to the skin surface and the other plate distal (or deep) to the skin surface having a component of a pneumatic/hydrulic driver for an implantable medical device such as a cardiac assist, cardiac support, or combined cardiac assist and support device and inducible magnet material on the distal plate of the bellows that can be magnetically drawn towards the proximal plate by the action of a magnet outside the body to contract the bellows or pressurize the fluid in the bellows.

ROTARY PULSATING VALVE AND METHOD FOR DISCHARGING FLUID

A valve for providing a pulsating discharge of fluid includes a valve assembly rotatably received within a housing. The housing is a tubular chamber with a fluid inlet port at a back end, a plurality of fluid outlet ports at a front end, with the valve assembly in between. The valve includes a lower body disposed adjacent the front end, and includes a plurality of valve openings that sequentially rotate into and out of communication with the fluid outlet ports as the valve assembly is rotated thereby causing a sequential discharge of fluid from the tubular chamber. The valve openings may have various dimensions thereby causing a variation in the pulsating fluid discharge effect. The distance between the valve lower body and the fluid outlet ports may be increased or decreased to allow uninterrupted fluid flow out of the tubular chamber and through the plurality of fluid outlet ports. 1. A valve , comprising:a housing extending between a front end and a back end comprising a tubular chamber;a fluid inlet port communicating with the chamber;a plurality of fluid outlet ports disposed within the housing front end communicating with the chamber;a valve assembly disposed within the housing, the valve assembly extending between a lower body and an upper body, the lower body disposed and rotatably mounted within the chamber between the fluid inlet port and the plurality of fluid outlet ports, the lower body adjacent the housing front end;at least one valve opening disposed within the lower body communicating with the chamber at a first end and the fluid outlet ports at a second end; andthe valve assembly rotatable to sequentially pass the valve opening second end into communication with a fluid outlet port thereby causing a sequential discharge of fluid from the chamber.2. The valve of in which the valve opening communicates with at least two adjacent fluid outlet ports.3. The valve of claim 2 , in which the fluid outlet ports are disposed in an annular array.4. The valve ...

Topical formulation comprising a corticosteroid as active ingredient

Formulation in the form of aqueous suspension of drug particles of a corticosteroid for topical administration are effective for the prophylaxis and/or treatment of a dermatological disease such as atopic dermatitis, acne and psoriasis.

REMOVABLE BREAK-AWAY SHACKLE ASSEMBLY

A removable break-away shackle assembly for suspending an animal carcass during processing includes a shackle connected to a drop rod, where the drop rod is connected to a conveyor system. The drop rod includes an elongated body with a connector at one end. The shackle includes bendable opposing arms forming a widenable gap. The shackle is separable from the drop rod by passing the drop rod through the widenable gap causing the arms to bend and the gap to widen, or by passing the widenable gap across a depression in the drop rod. 1. A shackle assembly for suspending a carcass from a conveyor system , comprising: the first end is adapted for connection to the conveyor system; and', 'the second end includes a connector, and the connector includes a depression having a width;, 'a rod extending between a first end and a second end, wherein 'a resilient upper portion connected to the connector, comprising:', 'a shackle for retaining the carcass, comprisinga bendable first arm; andan opposing bendable second arm forming a widenable gap having a gap width; andwherein the width of the depression is approximately the same as the width of the widenable gap, whereby the widenable gap may pass over the depression thereby allowing the shackle to be removed or attached to the rod.2. The shackle assembly of claim 1 , wherein the connector is a hook.3. The shackle assembly of claim 1 , wherein the connector further includes:a lateral; andthe depression is located on the lateral.4. The shackle assembly of claim 1 , wherein the depression has an oblong cross-section.5. The shackle assembly of claim 1 , wherein the depression has a scallop cross-section.6. The shackle assembly of claim 1 , wherein:the connector has a cross-sectional width;the depression has a cross-sectional width and a cross-sectional length;the cross-sectional width of the depression is less than a maximum cross-sectional width of the connector; andthe depression cross-sectional length is greater than the depression ...

BIRD CAVITY WASHER

A probe for cleaning the eviscerated body cavity of an animal, including a bird, has a washer assembly rotatably mounted about a tube. The washer assembly includes a nose having apertures extending between the interior and exterior of the nose. A bore within the tube feeds fluid to the apertures in the nose. As the probe is inserted into and withdrawn from the body cavity the nose rotates and fluid washes the body cavity. Alternatively, the probe includes a helical auger mounted about the tube that rotates as the probe moves into and out of the body cavity to assist in agitating the fluid within the body cavity and to displace the leaf fat. The nose may seal the anterior opening of the bird carcass to allow the body cavity to fill with fluid and the auger to agitate the accumulated fluid. 1. A probe for cleaning the eviscerated body cavity of an animal carcass , comprising:a tube extending between an upper end and a lower end, the tube having an axial bore extending between the upper end and the lower end;an upper port at the tube upper end communicating with the tube bore and the exterior of the tube; 'a tubular nose portion extending between an upper end and a lower end, the lower end disposed proximal to the tube lower end, the nose having at least one aperture communicating between the interior and exterior of the nose;', 'a washer assembly rotatably mounted about the tube, comprisingat least one port at the tube lower end communicating with the tube bore and the interior of the nose.2. The probe of claim 1 , wherein the at least one port includes a plurality of apertures in a spaced radial pattern projecting downward and away from the nose claim 1 , and plurality of apertures in a spaced radial pattern projecting upward and away from the nose.3. The probe of claim 1 , wherein the washer assembly further comprises:a spacer having a tubular body rotatably mounted about the tube above the nose, wherein the spacer extends between an upper end and a lower end;a ...

DEPLOYMENT METHODS AND MECHANISMS FOR MINIMALLY INVASIVE IMPLANTATION OF HEART CONTACTING CARDIAC DEVICES

The present invention provides methods, systems, kits, and devices that aid in the positioning of a direct cardiac compression device about the heart. 1. A method of insertion of a DCCD comprising the steps of:obtaining pericardial access to a pericardial sac;separating the pericardial sac from an apex of a heart;creating a space for the deployment of a direct cardiac compression device;providing the direct cardiac compression device having one or more pockets on the exterior or interior of the direct cardiac compression device;providing an insertion device having one or more retractable loops;extending the one or more retractable loops from the insertion device;contacting the one or more pockets of the direct cardiac compression device with the one or more retractable loops;expanding the direct cardiac compression device around the apex of a heart;positioning the direct cardiac compression device about the apex of a heart;retracting the one or more retractable loops into the insertion device;dissociating the insertion device from the direct cardiac compression device andremoving the insertion device.2. The method of claim 1 , wherein the one or more retractable loops comprise a metal claim 1 , a nonmetal claim 1 , a plastic claim 1 , a polymer claim 1 , a composite claim 1 , an alloy claim 1 , or a combination thereof.3. The method of claim 1 , wherein the framework induces flaring from the insertion device to allow the positioning of the DCCD about the apex of a heart.4. The method of claim 1 , wherein the insertion device is placed inside an insertion tube.5. The method of claim 1 , wherein the direct cardiac compression device is placed inside an insertion tube.6. The method of claim 1 , wherein the insertion device and the direct cardiac compression device are placed inside an insertion tube.7. A direct cardiac compression heart assist insertion device comprising:a housing;one or more retractable loops extending retractably from the housing, wherein the one or ...

COMBINATION AUTOMATED & HAND DEBONING APPARATUS & METHOD WITH SINGLE UNIT PROCESSING

An apparatus and method for separating wanted tissues from a bird carcass comprises mechanical and manual manipulation of the tissues. Mechanical manipulation includes scoring the lateral side of the carcass below the ribs between the neck opening and vent to separate the breast tissue from the skeletal system, and cutting the breast tissue and tenderloin tissue from the breast bone. Manual manipulation of the wanted tissues includes: mounting the carcass on a fixture, grasping the breast tissue adjacent the neck opening, and moving the hand toward the vent to separate the breast tissue from the carcass; and grasping the tenderloin tissue adjacent the neck opening, and moving the hand toward the vent to separate the tenderloin tissue from the carcass. Alternatively, the breast tissue may be harvested as a butterfly filet by scoring the lateral side of the carcass and removing the breast tissue from the carcass. 1. A cut assembly for cutting an item on an item mount , the cut assembly comprising:a blade mount biased toward the item mount; anda blade connected to the blade mount.2. The cut assembly of claim 1 , wherein the blade is pivotally connected to the blade mount.3. The cut assembly of claim 1 , wherein the blade mount includes an articulated assembly for aligning the blade with the item mount.4. The cut assembly of claim 1 , wherein the articulated assembly includes:an arm;a support connected to the arm;a jig connected to the arm and the blade mount; andan extension extending between the arm and the jig.5. The cut assembly of claim 4 , wherein:the support is pivotally connected to a first end of the arm;the jig is connected to a second end of the arm; anda biasing member extends between the support and the arm first end for biasing the blade toward the mount.6. The cut assembly of claim 5 , wherein the jig includes:a body extending between a first end and a second end;the body first end is connected to the extension;the blade mount is pivotally connected to ...

REMOVABLE BREAK-AWAY SHACKLE ASSEMBLY

A removable break-away shackle assembly for suspending an animal carcass during processing includes a shackle connected to a drop rod, where the drop rod is connected to a conveyor system. The drop rod includes an elongated body with a connector at one end. The shackle includes bendable opposing arms forming a widenable gap. The shackle is separable from the drop rod by passing the drop rod through the widenable gap causing the arms to bend and the gap to widen, or by passing the widenable gap across a depression in the drop rod. 1. A shackle assembly for suspending a carcass from a conveyor system , comprising: the first end is adapted for connection to the conveyor system; and', 'the second end includes a connector, comprising:, 'a rod extending between a first end and a second end, whereina downward-extending bendable first arm;an opposing downward-extending bendable second arm; andwherein the first arm and second arm form an opening above a widenable opening, the widenable opening having an opening width; a frame comprising structural elements having a cross-sectional width; and', 'an upper portion including an upper opening for connecting to the rod second end; and, 'a shackle for retaining the carcass, the shackle comprisingwherein the cross-sectional width of the frame upper portion is approximately the same as the width of the widenable opening, whereby the frame may pass through the widenable opening thereby allowing the shackle to be removed or attached to the connector.2. The shackle assembly of claim 1 , wherein the shackle upper portion includes a nose having a circular cross-sectional width.3. The shackle assembly of claim 1 , wherein the widenable opening widens under a pre-established condition thereby separating the shackle from the connector.4. The shackle assembly of claim 3 , wherein the pre-established condition is a downward force applied to the shackle equivalent to approximately between 150 pounds and 250 pounds.5. The shackle assembly of ...

SELF-EXPANDING HEART ASSIST DEVICE

The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart. 1. A self-expanding wire framework comprising:a self-expanding wire framework covered with a polymer film adapted to flare outwardly to encircle a portion of the heart, wherein the self-expanding wire framework comprises:a set of articulated wire loops extending from a lead edge to a hub, wherein each of the articulated wire loops of the set of articulated wire loops comprise:a top segment positioned at the lead edge and that extends to a left midway bend and to a right midway bend,a left strut that extends from the left midway bend to the hub,a right strut that extends from the right midway bend to the hub, anda fixed strut attachment point on the hub to fix the position of the left strut and the right strut, wherein the left midway bend and right midway bend result in a tension that causes the self-expanding wire framework and the polymer film to engage in a circumferential flaring motion and bend outwardly as the self-expanding framework is deployed from the deployment tube.2. The device of claim 1 , wherein the left midway bends and the right midway bends are rounded to allow for gradual flaring as the self-expanding wire framework is deployed or wherein the left midway bends and the right midway bends are flattened to allow for flaring as the self-expanding wire framework is deployed.3. The device of claim 1 , wherein the left midway bends and the right midway bends further comprise multiple bends to allow for immediate flaring positions as the self-expanding wire framework is deployed.4. The device of claim 1 , wherein the articulated wire loops comprises flat wires claim 1 , oval wires ...

METHODS TO SELECTIVELY TREAT PORTIONS OF A SURFACE USING A SELF-REGISTERING MASK

Processes increase light absorption into silicon wafers by selectively changing the reflective properties of the bottom portions of light trapping cavity features. Modification of light trapping features includes: deepening the bottom portion, increasing the curvature of the bottom portion, and roughening the bottom portion, all accomplished through etching. Modification may also be by the selective addition of material at the bottom of cavity features. Different types of features in the same wafers may be treated differently. Some may receive a treatment that improves light trapping while another is deliberately excluded from such treatment. Some may be deepened, some roughened, some both. No alignment is needed to achieve this selectively. The masking step achieves self-alignment to previously created light trapping features due to softening and deformation in place. 1. A method for providing a texture to a semiconductor surface , the method comprising the steps of:a. providing a mask of material on the surface, which mask material is patterned so that some regions of the surface are covered with resist material, and a plurality of region are exposed;b. providing an etchant to the surface;c. allowing the etchant to etch away semiconductor material at the exposed regions, thereby producing a plurality of cavities in the surface, which cavities undercut the mask material, leaving overhanging portions of mask material;d. deforming the overhanging mask portions into covering proximity with a portion of the surface of the plurality of cavities, wherein at least a region of each cavity surface remains exposed; ande. providing, to the semiconductor surface a treating agent, of a type and under conditions such that, cavity surface portions covered by the mask resist treatment and the exposed regions of the cavities become treated.2. The method of claim 1 , the treating agent comprising an etchant.3. The method of claim 1 , the treating agent adding material.4. The method ...

COMPOSITIONS FOR INHIBITING INFLAMMATION IN A SUBJECT WITH A SPINAL CORD INJURY AND METHODS OF USING THE SAME

Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-α signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed. 1. A composition for inhibiting inflammation in a subject with a spinal cord injury comprising:one or more agents capable of specifically reducing TNF-α signaling; anda biodegradable carrier.2. The composition of claim 1 , wherein the one or more agents comprise a TNF-α inhibitor claim 1 , a protein that specifically binds TNF-α claim 1 , an anti-inflammatory cytokine claim 1 , or any combination thereof.3. The composition of claim 2 , wherein the protein that specifically binds TNF-α is etanercept claim 2 , infliximab claim 2 , adalimumab claim 2 , certolizumab pegol claim 2 , or any combination thereof.4. The composition of claim 2 , wherein the protein that specifically binds is an antibody.5. The composition of claim 2 , wherein the TNF-α inhibitor is pentoxifylline claim 2 , methotrexate claim 2 , pirfenidone claim 2 , bupropion claim 2 , or any combination thereof.6. The composition of claim 2 , wherein the anti-inflammatory cytokine is IL-10 claim 2 , IL-4 claim 2 , or any combination thereof.7. The composition of claim 1 , wherein the one or more agents are exposed on the surface of the biodegradable carrier claim 1 , incorporated within the biodegradable carrier claim 1 , or both.8. The composition of claim 1 , wherein the one or more agents are exposed on the surface of the biodegradable carrier.9. The composition of claim 8 , wherein the one or more agents comprise a protein that specifically binds TNF-α.10. The ...

Process technology for biological product manufacturing and downstream purification

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

CARDIAC COMPRESSION DEVICE HAVING PASSIVE AND ACTIVE CHAMBERS

The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function. 1. A direct cardiac compression device adapted to surround a heart and comprising an inner membrane adapted to surround the heart,', 'a connecting membrane in communication with the inner membrane to form inner passive chambers, and', 'a passive fluid deposited in the inner passive chambers, wherein the inner passive chambers conform to the shape of the heart;, 'an inner passive chambers comprising an outer member in communication with the connecting membrane,', 'to form outer active chambers, and', 'an active fluid disposed in the outer active chambers;, 'an outer active chambers comprisingan input connection in fluid communication with the outer active chambers to ingress the active fluid into the outer active chambers, andan output connection in fluid communication with the outer active chambers to egress the fluid from the outer active chambers, wherein the active fluid presses on the inner passive chambers to compress the heart.2. The device of claim 1 , further comprising one or more passive dividers located between the inner membrane and the connecting membrane to form passive chambers.3. The device of claim 1 , further comprising one or more active dividers located between the outer membrane and the connecting membrane to form baffled chambers.4. The device of claim 1 , wherein the outer membrane and the connecting membrane are the same membrane.5. The device of claim 1 , wherein the inner membrane and the connecting membrane are sealed together; wherein the connecting membrane and the outer membrane are sealed together.6. A direct cardiac compression device adapted to surround the heart and comprising an inner membrane adapted to surround the heart,', 'a connecting membrane in communication with the inner membrane to form an inner passive chambers, and', 'a passive fluid deposited in the inner ...

Orthotic riding stirrup and boot interface

An orthotic stirrup interface between a horse and a rider is disclosed. Aspects of the invention include an improved stirrup, an orthotic riding boot, and an indexed interface between the stirrup and orthotic riding boot. Embodiments of the present invention provide for a positive indexed engagement between the foot of a rider and the stirrups. The positive indexed engagement provides greater stability and control of the rider with the horse, improves safety of the rider and horse. An orthotic profile to the stirrup reduces pain and discomfort in the rider's feet. Embodiments for each of a thoroughbred racing stirrup and a therapy riding stirrup and associated footwear are disclosed.

Compositions For An Injectable, In Situ Forming Neuroscaffold And Methods Of Using The Same

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

Process technology for biological product manufacturing and downstream purification

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Compositions For Treating Acute, Post-Operative, or Chronic Pain and Methods of Using the Same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. 1. A composition for treating acute , post-operative , or chronic pain in a subject comprising:an anticonvulsant agent in the absence of a local anesthetic; anda carrier comprising poly(lactide-co-glycolides), poly(lactides), copolymers of these said polymers with poly(ethylene glycol), or any combination thereof,wherein the anticonvulsant agent is incorporated within the biodegradable carrier by solvent extraction/evaporation, oil-in-water single emulsification, by spray drying, or by precipitation using a solvent/non-solvent system.2. The composition of claim 1 , wherein the anticonvulsant agent comprises carbamazepine claim 1 , pregabalin claim 1 , phenytoin claim 1 , gabapentin claim 1 , topiramate claim 1 , or oxcarbazepine claim 1 , or any combination thereof.3. The composition of claim 1 , wherein the anticonvulsant agent is carbamazepine.4. The composition of claim 1 , wherein the anticonvulsant agent is gabapentin.5. The composition of claim 1 , wherein the anticonvulsant agent is pregabalin.6. The composition of claim 1 , wherein the anticonvulsant agent is phenytoin.7. The composition of claim 1 , wherein the anticonvulsant agent is exposed on the surface of the carrier claim 1 , incorporated within the carrier claim 1 , or both.8. The composition of claim 1 , wherein the carrier comprises a microparticle claim 1 , a nanoparticle claim 1 , or any combination thereof.9. The composition of claim 8 , wherein the microparticle has a median hydrodynamic diameter of greater than or equal to 1 micron and up to 25 microns claim 8 , inclusive claim 8 , as ...

METHODS FOR TREATING EPILEPSY OR SEIZURE DISORDERS

Provided herein are methods for treating epilepsy or seizure disorders comprising administering a composition to a subject, the composition comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. 1. A method of treating a subject having epilepsy or seizure disorders comprising administering to said subject a composition comprising:an anticonvulsant agent; anda carrier comprising poly(lactide-co-glycolides), poly(lactides), or a copolymer of said poly(lactide-co-glycolides) or said poly(lactides) with poly(ethylene glycol), or any combination thereof,wherein the anticonvulsant agent is incorporated within the carrier by solvent extraction/evaporation, oil-in-water single emulsification, by spray drying, or by precipitation using a solvent/non-solvent system.2. The method of claim 1 , wherein the composition is administered intracranially claim 1 , as to bypass the blood-brain barrier claim 1 , in said subject.3. The method of claim 1 , wherein the composition is administered near or around a focal lesion of said subject.4. The method of claim 1 , wherein the composition is administered into or around a resection cavity of said subject.5. The method of claim 1 , wherein the composition is administered into or around the temporal lobe of said subject.6. The method of claim 1 , wherein the composition is administered into or around the frontal lobe of said subject.7. The method of claim 1 , wherein the composition is administered into or around the parietal lobe of said subject.8. The method of claim 1 , wherein the composition is administered into or around occipital lobe of said subject.9. The method of claim 1 , wherein the composition is injected or surgically implanted in said subject.10. The method of claim 1 , wherein the epilepsy or seizure disorder is caused by epilepsy or seizure disorders caused by trauma claim 1 , traumatic brain injury claim 1 , fever claim 1 , infection claim 1 , ...

Compositions For Treating Acute, Post-Operative, Or Chronic Pain and Methods of Using the Same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. 1. A composition for treating acute , post-operative , or chronic pain in a subject comprising:an anticonvulsant agent; anda biodegradable carrier comprising poly(lactide-co-glycolides), poly(lactides), or copolymers of these said polymers with poly(ethylene glycol),wherein the anticonvulsant agent is incorporated within the biodegradable carrier by solvent extraction/evaporation, oil-in-water single emulsification, by spray drying, or by precipitation using a solvent/non-solvent system.2. The composition of claim 1 , wherein the anticonvulsant agent comprises carbamazepine claim 1 , pregablin claim 1 , phenytoin claim 1 , gabapentin claim 1 , topiramate claim 1 , or oxcarbazepine claim 1 , or any combination thereof.3. The composition of claim 1 , wherein the anticonvulsant is carbamazepine.4. The composition of claim 1 , wherein the anticonvulsant is gabapentin.5. The composition of claim 1 , wherein the anticonvulsant is pregabalin.6. The composition of claim 1 , wherein the anticonvulsant agent is exposed on the surface of the biodegradable carrier claim 1 , incorporated within the biodegradable carrier claim 1 , or both.7. The composition of claim 1 , wherein the biodegradable carrier comprises a microparticle claim 1 , a nanoparticle claim 1 , or any combination thereof.8. The composition of claim 7 , wherein the biodegradable carrier has a mean hydrodynamic diameter of up to 25 microns claim 7 , inclusive claim 7 , as measured by aqueous solution phase laser diffraction or dynamic light scattering instrumentation.9. The composition of claim 7 , ...

POWER ELECTRONIC DEVICE

A device includes a first and second transistors integrated in first and second chips. Each chip has opposed rear and front surfaces, and further has a first conduction terminal and a control terminal on the front surface and a second conduction terminal on the rear surface. The first and second transistors are electrically connected in series by having the first conduction terminals of the first and second transistors be electrically connected. The device includes a common package enclosing the first and second chips, the common package having an insulating body with a mounting surface. A heat sink is also enclosed within the insulating body, the heat sink making electrical contact with the first conduction terminals of the first and second chips on the respective front surfaces, so that the first conduction terminals are electrically connected together through the heat sink. 1. An electronic device , comprising:a first transistor integrated in a first chip;a second transistor integrated in a second chip;wherein each chip has a rear surface and a front surface opposite to each other, a first conduction terminal and a control terminal of the corresponding transistor on the front surface and a second conduction terminal of the corresponding transistor on the rear surface, the first transistor and the second transistor being connected with the first conduction terminal of the first transistor connected to the first conduction terminal of the second transistor;a common package comprising an insulating body enclosing the first transistor and the second transistor and having a mounting surface; anda heat sink enclosed in the insulating body in contact with the first conduction terminals of the first and second chips on the respective front surfaces, so that the first conduction terminals are electrically connected together by means of the heat sink.2. The electronic device of claim 1 , further comprising a first further heat sink and a second further heat sink enclosed ...

DIASTOLIC RECOIL METHOD AND DEVICE FOR TREATMENT OF CARDIAC PATHOLOGIES

The present invention provides methods and direct cardiac contact device to improve the diastole phase and the systolic phase of a heart and includes a biocompatible film pneumatic locked to the heart to aid in heart compression and relaxation. 1. A direct cardiac contact diastolic recoil device to improve diastolic recoil of a heart , comprising:a biocompatible inner film adapted to fit about the heart, wherein the biocompatible inner film is in constant contact with the heart to form a pneumatic lock with the heart;an outer film in contact with the biocompatible inner film;one or more fluid chambers formed between the biocompatible inner film and the outer film; anda fluid connection in fluid communication with the one or more fluid chambers, wherein a fluid enters the one or more fluid chambers through the fluid connection to selectively compress the heart during a heart contraction and during recoil the fluid exits the one or more fluid chambers through the fluid connection to decompress the pneumatically locked biocompatible inner film and pull open the heart to aid in filling of the heart.2. The device of claim 1 , further comprising a pneumatic driver operably linked to the fluid connection to pressurize the biocompatible inner membrane to compress the heart and depressurize the biocompatible inner membrane to aid in filling the heart.3. The device of claim 1 , wherein the biocompatible inner membrane comprises an elastomeric biocompatible material.4. The device of claim 1 , further comprising one or more structural elements disposed about the biocompatible inner membrane to further aid in adding diastolic recoil.5. The device of claim 1 , wherein the device applies varying pressure claim 1 , uniform pressure or both to the surface of the heart to alter the end systolic configuration of the heart claim 1 , the end diastolic configuration of the heart claim 1 , or both.6. The device of claim 1 , wherein the device separately modulates the end systolic and end ...

PROCESS TECHNOLOGY FOR BIOLOGICAL PRODUCT MANUFACTURING AND DOWNSTREAM PURIFICATION

Provided herein are, inter alia, biological manufacturing and downstream purification processes. 1. A dynamic filtration apparatus for removing impurities from a biological product in a heterogeneous mixture , comprising:a filter membrane extending between a feed reel and a collection reel, the filter membrane having a target region that is configured to receive the heterogeneous mixture from at least one output head configured to dispense the heterogeneous mixture onto the target region;a membrane support structure to structurally support a portion of the filter membrane that is positioned between the feed reel and the collection reel to create the target region;at least one support member to stabilize the transport of the filter membrane across the membrane support structure;a vacuum system configured to apply negative gauge pressure across the dynamic filter membrane.2. The apparatus of claim 1 , further comprising a wash buffer line.3. The apparatus of claim 1 , wherein the filter membrane comprises polyethersulfone (PES) claim 1 , hydrophilic polysulfone claim 1 , cellulose ester claim 1 , cellulose acetate claim 1 , polyvinylidene fluoride (PVDF) claim 1 , hydrophilic PVDF claim 1 , polycarbonate claim 1 , nylon claim 1 , polytetrafluoroethylene (PTFE) claim 1 , hydrophilic PTFE claim 1 , or any combination thereof.4. The apparatus of claim 1 , wherein the filter membrane comprises a pore size in the range from about 0.1 μm to about 1 μm.5. The apparatus of claim 1 , wherein the membrane support structure includes a series of parallel slots.6. The apparatus of claim 1 , wherein the gauge pressure ranges from about −0.05 bar to about −0.98 bar.7. The apparatus of claim 1 , wherein the membrane support structure has a substantially smooth contact surface.8. The apparatus of claim 1 , wherein the support member has a substantially smooth contact surface.9. The apparatus of claim 7 , wherein the substantially smooth contact surface has a static coefficient of ...

Biphasic and Dynamic Adjustable Support Devices and Methods with Assist and Recoil Capabilities for Treatment of Cardiac Pathologies

The present invention provides a biphasic and dynamic direct cardiac contact device adapted to be implanted in a patient suffering from congestive heart failure and related cardiac pathologies, said cardiac device having means for providing ventricular assist, ventricular support and diastolic recoil, or for providing ventricular support and diastolic recoil only. 1. A method of using a direct cardiac contact ventricular assist , ventricular support and diastolic recoil device or a direct cardiac contact ventricular support and diastolic recoil device only , comprising the steps of:determining a phase transitioning point (target end diastolic volume (TEDV)); andoperating in a biphasic mode about an adjustable phase transition point (TEDV).2. The method of claim 1 , further comprising the steps of:enhancing filling in a filling enhancement phase when cardiac volumes are below TEDV; andimpeding filling (i.e., “filling impediment” phase) when cardiac volumes above TEDV.3. The method of claim 1 , comprising the step of using a dynamic adjustable support during the filling impediment of the biphasic component.4. The method of claim 1 , comprising the step of continually applying support to the epicardial surface of the heart claim 1 , thereby promoting reverse remodeling.5. The method of claim 1 , wherein as the diseased heart begins to respond to the support by becoming smaller claim 1 , adjusting the TEDV to provide the same amount of support as the initial treatment intervention.6. The method of claim 2 , wherein the filling enhancement of the biphasic component enhances diastolic recoil when the elastic memory component is utilized when cardiac pressures are lower than TEDV by creating a negative pressure that promotes ventricle filling and when cardiac pressure exceed TEDV claim 2 , filling and cardiac volume is constrained.7. A direct cardiac contact diastolic recoil device to improve diastolic recoil of a heart and reduce postoperative pericardial adhesion ...

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CONDITIONS

Provided herein are compositions comprising a stable water-in-silicone emulsion, and methods and kits comprising the compositions for treating conditions. 1. A composition comprising a stable water-in-silicone emulsion having a continuous silicone phase and an aqueous phase ,wherein the emulsion comprises a sterol at a concentration from about 0.1% to about 4% by weight of the total weight of the composition.2. The composition of claim 1 , wherein the sterol is at a concentration from about 1% to about 2% by weight of the total weight of the composition.3. The composition of claim 1 , wherein the sterol comprises cholesterol or cholesterol derivatives.4. The composition of claim 1 , wherein the silicone phase comprises a silicone oil claim 1 , a silicone gum claim 1 , or a combination thereof.5. The composition of claim 4 , wherein the silicone oil comprises dimethicone claim 4 , cyclomethicone claim 4 , caprylyl methicone claim 4 , or cyclopentasiloxane.6. The composition of claim 4 , wherein the silicone gum comprises dimethiconol.7. The composition of claim 1 , further comprising at least one co-emulsifier.8. The composition of claim 7 , wherein the co-emulsifier comprises glyceryl stearate claim 7 , glyceryl monostearate claim 7 , sorbitan monolaurate claim 7 , sorbitan monopalmitate claim 7 , sorbitan monostearate claim 7 , sorbitan tristearate claim 7 , sorbitan monooleate claim 7 , sorbitan trioleate claim 7 , polyoxyethylene sorbitan monolaurate claim 7 , polyoxyethylene sorbitan monopalmitate claim 7 , polyoxyethylene sorbitan monostearate claim 7 , polyoxyethylene sorbitan tristearate claim 7 , polyoxyethylene sorbitan monooleate claim 7 , polyoxyethylene sorbitan trioleate claim 7 , polyoxyethylene monolaurate claim 7 , polyoxyethylene monostearate claim 7 , polyoxyethylene monopalmitate claim 7 , polyoxyethylene monooleate claim 7 , lecithin claim 7 , PEG/PPG-18/18 dimethicone claim 7 , cetyl PEG/PPG-10/1 dimethicone claim 7 , dimethicone copolyol claim ...

Self-Expanding Heart Assist Device

The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart. 2. The device of claim 1 , wherein the connector is a crimp connector.3. The device of claim 1 , wherein the connector is a crimp connector claim 1 , a wire connector claim 1 , an adhesive claim 1 , a weld claim 1 , a clip or a combination thereof.4. The device of claim 1 , wherein the top segment claim 1 , the left midway bend and the right midway bend form a triangular shape.5. The device of claim 1 , wherein the top segment claim 1 , the left midway bend claim 1 , the right midway bend the left strut and the right strut form a diamond shape.6. The device of claim 1 , further comprising a second self-expanding wire framework positioned in a staggered relationship to the first self-expanding wire framework.7. The device of claim 1 , wherein the left midway bends and the right midway bends are rounded to allow for gradual flaring as the self-expanding wire framework is deployed or wherein the left midway bends and the right midway bends are flattened to allow for flaring as the self-expanding wire framework is deployed.8. The device of claim 1 , wherein the left midway bends and the right midway bends further comprise multiple bends to allow for immediate flaring positions as the self-expanding wire framework is deployed.9. The device of claim 1 , where the self-expanding wire framework comprises at least 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , 11 claim 1 , 12 claim 1 , 13 claim 1 , 14 claim 1 , 15 claim 1 , 16 claim 1 , 17 claim 1 , 18 claim 1 , 19 claim 1 , 20 or more adjacent articulated wire loops.10. The device of claim 1 ...

Compositions For Treating Acute, Post-Operative, Or Chronic Pain and Methods of Using the Same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. 1. A method of treating a subject having acute , post-operative , or chronic pain comprising administering to said subject a composition comprising:an anticonvulsant agent; anda biodegradable carrier.2. The method of wherein the biodegradable carrier comprises poly(lactide-co-glycolides) claim 1 , poly(lactides) claim 1 , or copolymers of these said polymers with poly(ethylene glycol) claim 1 , and claim 1 ,wherein the anticonvulsant agent is incorporated within the biodegradable carrier by by solvent extraction and evaporation oil-in-water single emulsification, by spray drying, or by precipitation using a solvent and non-solvent system.3. The method of claim 1 , wherein the composition is administered into and/or around the epidural space in said subject.4. The method of claim 1 , wherein the composition is administered into and/or around an intra-articular joint of said subject.5. The method of claim 1 , wherein the composition is administered into and/or around a facet joint of said subject.6. The method of claim 1 , wherein the compositions is administered into and/or around intramuscular tissue in said subject.7. The method of claim 1 , wherein the composition is administered on or near a sensory nerve of said subject.8. The method of claim 7 , wherein the sensory nerve is the femoral nerve.9. The method of claim 7 , wherein the sensory nerve is the sciatic nerve.10. The method of claim 7 , wherein the sensory nerve is the brachial plexus.11. The method of claim 7 , wherein the sensory nerve is the inferior alveolar nerve.12. The method of claim 7 , ...

COMPOSITIONS COMPRISING NAv1.7 SELECTIVE INHIBITORS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising a Na1.7 selective inhibitor and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in a subject are also disclosed herein. 1. A composition for treating acute , post-operative , or chronic pain in a subject comprising: a Na1.7 selective inhibitor; anda biodegradable carrier.2. The composition of claim 1 , wherein the Na1.7 selective inhibitor comprises GX-936 claim 1 , GDC-0310 claim 1 , GDC-0276 claim 1 , CNV1014802 claim 1 , PF05089771 claim 1 , AZD3161 claim 1 , DSP-2230 claim 1 , XEN402 claim 1 , XEN403 claim 1 , ProTx-II claim 1 , or any combination thereof.3. The composition of claim 1 , wherein the biodegradable carrier comprises poly(lactide-co-glycolides) claim 1 , poly(lactides) claim 1 , copolymers of these said polymers with poly(ethylene glycol) claim 1 , or any combination thereof.4. The composition of claim 1 , wherein the Na1.7 selective inhibitor is incorporated within the biodegradable carrier by emulsification claim 1 , by spray drying claim 1 , by coacervation claim 1 , or by precipitation using a solvent/non-solvent system.5. The composition of claim 1 , wherein the Na1.7 selective inhibitor is GDC-0310.6. The composition of claim 1 , wherein the Na1.7 selective inhibitor is GDC-0276.7. The composition of claim 1 , wherein the Na1.7 selective inhibitor is CNV1014802.8. The composition of claim 1 , wherein the Na1.7 selective inhibitor is PF05089771.9. The composition of claim 1 , wherein the Na1.7 selective inhibitor is XEN402.10. The composition of claim 1 , wherein the Na1.7 selective inhibitor is exposed on the surface of the biodegradable carrier claim 1 , incorporated within the carrier claim 1 , or both.11. The composition of claim 1 , wherein the ...

Compositions Comprising NAv1.7 Selective Inhibitors For Treating Acute, Post-Operative, Or Chronic Pain And Methods Of Using The Same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising a Na1.7 selective inhibitor and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. 1. A composition for treating acute , post-operative , or chronic pain in a subject comprising:{'sub': 'v', 'a Na1.7 selective inhibitor; and'}a biodegradable carrier comprising poly(lactide-co-glycolides), poly(lactides), copolymers of these said polymers with poly(ethylene glycol), or any combination thereof, wherein:{'sub': 'v', 'the Na1.7 selective inhibitor is dispersed within the biodegradable carrier;'}{'sub': 'v', 'the Na1.7 selective inhibitor is incorporated within the biodegradable carrier by emulsification, by spray drying, or by coacervation, using a solvent/non-solvent system; and,'}the biodegradable carrier comprises non-porous microparticles, non-porous nanoparticles, or a combination thereof, the microparticles having a mean or median hydrodynamic diameter of up to 25 microns, inclusive, as measured by aqueous solution phase laser diffraction or dynamic light scattering instrumentation.2. The composition of claim 1 , wherein the Na1.7 selective inhibitor comprises GX-936 claim 1 , GDC-0310 claim 1 , GDC-0276 claim 1 , CNV1014802 claim 1 , PF05089771 claim 1 , AZD3161 claim 1 , DSP-2230 claim 1 , XEN402 claim 1 , XEN403 claim 1 , ProTx-II claim 1 , or any combination thereof.3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (Canceled)10. The composition of claim 1 , wherein the Na1.7 selective inhibitor is exposed on the surface of the biodegradable carrier.11. The composition of claim 1 , wherein the Na1.7 selective inhibitor is incorporated within the biodegradable carrier in the absence of a local ...

FORMULATION FOR ACIDIC WET CHEMICAL ETCHING OF SILICON WAFERS

Acid etch compositions for etching multicrystalline silicon substrates are disclosed which may include hydrofluoric acid, an oxidizer, an acid diluent, and soluble silicon. The soluble silicon may be hexafluorosilicic acid or ammonium fluorosilicate. Silicon substrates patterned with organic resist may be used with the acid etch compositions for selective silicon patterning for solar cell applications. 1. A method of patterning silicon , comprising:exposing a silicon substrate patterned with organic resist on at least one surface to an as-prepared etching composition, the etching composition comprising hydrofluoric acid, at least one oxidizer capable of oxidizing silicon, and soluble silicon,wherein the etching composition etches exposed silicon surface of the silicon substrate without removing the organic resist.2. The method of further comprising:per unit silicon etched, removing a volume fraction of the etching composition while simultaneously replenishing the etchant bath with a replenishment solution comprising hydrofluoric acid and at least one aqueous-soluble oxidizer capable of oxidizing silicon.3. The method of claim 1 , wherein the soluble silicon is selected from the group consisting of fluorosilicates claim 1 , silicic acid claim 1 , silicates claim 1 , soluble silicon claim 1 , and combinations thereof.4. The method of wherein the fluorosilicate is selected from the group consisting of hexafluorosilicic acid and ammonium fluorosilicate and combinations thereof.5. The method of claim 1 , wherein the oxidizer is selected from the group consisting of nitric acid claim 1 , nitrous acid claim 1 , iodic acid claim 1 , peroxides claim 1 , chlorates claim 1 , perchlorates claim 1 , chromates claim 1 , dichromates claim 1 , nitrites claim 1 , nitrates claim 1 , permanganates claim 1 , persulfates claim 1 , iodates claim 1 , periodates and combinations thereof.6. The method of claim 1 , wherein the etching composition further comprises at least one diluent.7. The ...

Compositions For Treating Acute, Post-Operative, Or Chronic Pain And Methods of Using The Same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. 114-. (canceled)15. A method of treating a subject having acute , post-operative , or chronic pain comprising administering to said subject a composition comprising:an anticonvulsant agent; anda biodegradable carrier.16. The method of wherein the biodegradable carrier comprises poly(lactide-co-glycolides) claim 15 , poly(lactides) claim 15 , or copolymers of these said polymers with poly(ethylene glycol) claim 15 ,and,wherein the anticonvulsant agent is incorporated within the biodegradable carrier by solvent extraction/evaporation, oil-in-water single emulsification, by spray drying, or by precipitation using a solvent/non-solvent system.17. The method of claim 15 , wherein the composition is administered into and/or around the epidural space in said subject.18. The method of claim 15 , wherein the composition is administered into and/or around an intra-articular joint of said subject.19. The method of claim 15 , wherein the composition is administered into and/or around a facet joint of said subject.20. The method of claim 15 , wherein the compositions is administered into and/or around intramuscular tissue in said subject.21. The method of claim 15 , wherein the composition is administered on or near a sensory nerve of said subject.22. The method of claim 21 , wherein the sensory nerve is the femoral nerve.23. The method of claim 21 , wherein the sensory nerve is the sciatic nerve.24. The method of claim 21 , wherein the sensory nerve is the brachial plexus.25. The method of claim 21 , wherein the sensory nerve is the inferior alveolar nerve.26. The ...

FULLY IMPLANTABLE DIRECT CARDIAC AND AORTIC COMPRESSION DEVICE

The present invention provides a combined direct cardiac compression and aortic counterpulsation device comprising: an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart. 1. A combined direct cardiac compression and aortic counterpulsation device comprising:an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom,an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, anda driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.2. A combined direct cardiac compression and aortic counterpulsation device comprising:an inflatable direct cardiac compression jacket configured when inflated to directly compress an external surface of a heart and assist in displacing blood therefrom,an aortic counterpulsation chamber configured when inflated to displace ...

Fully Implantable Direct Myocardium Assist Device

The present invention provides an implantable cardiac compression device comprising: an inflatable cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, a channel that connects the inflatable cardiac compression jacket and an expandable fluid reservoir configured to contain a fluid when displaced compresses the inflatable cardiac compression jacket, and a fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to inflate the cardiac compression jacket and to deflate the expandable fluid reservoir during systole of the heart; said driver is further configured to deflate the cardiac compression jacket and to inflate the expandable fluid reservoir during diastole of the heart. 1. An implantable cardiac compression device comprising:an inflatable cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom;a channel that connects the inflatable cardiac compression jacket andan expandable fluid reservoir configured to contain a fluid when displaced from the inflatable cardiac compression jacket, wherein the expandable fluid reservoir is adapted to be positioned adjacent the pericardium; anda fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to inflate the cardiac compression jacket and to deflate the expandable fluid reservoir during systole of the heart; said driver is further configured to deflate the cardiac compression jacket and to inflate the expandable fluid reservoir during diastole of the heart.2. An implantable cardiac compression device comprising:an inflatable cardiac compression device comprising a resilient inner panel in contact with a heart periphery comprising one or more membranes contoured to provide curvatures generally in ...

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CONDITIONS

Provided herein are compositions comprising a stable water-in-silicone emulsion, and methods and kits comprising the compositions for treating conditions. 1. A composition comprising a stable water-in-silicone emulsion havinga continuous silicone phase and an aqueous phase,wherein the emulsion comprises a non-silicone emulsifier comprising cholesterol or a cholesterol derivative at a concentration from about 0.1% to about 4% by weight of the total weight of the composition and a sorbitan ester.229-. (canceled)30. A method for treating or preventing a condition in a subject , comprising:applying to a tissue surface a composition comprising a stable water-in-silicone emulsion having a continuous silicone phase and an aqueous phase,wherein the emulsion comprises a non-silicone emulsifier comprising cholesterol or a cholesterol derivative at a concentration from about 0.1% to about 4% by weight of the total weight of the composition and a sorbitan ester, andwherein the composition is used in an amount effective to treat said condition.31. The method of claim 30 , wherein the tissue surface comprises an epithelial surface or a mucosal surface.32. The method of claim 30 , wherein the condition comprises a vaginal condition or a rectal condition.33. The method of claim 32 , wherein the vaginal condition comprises a decrease in estrogen concentration claim 32 , atrophic vaginitis claim 32 , vulvar and vaginal atrophy claim 32 , bacterial vaginosis claim 32 , vaginal dryness claim 32 , vaginal itch claim 32 , vaginal irritation claim 32 , dyspareunia claim 32 , bacterial infection claim 32 , yeast infection claim 32 , urinary tract infection claim 32 , menopause claim 32 , peri-menopause claim 32 , post-menopause claim 32 , a sexually transmitted infection claim 32 , sexually transmitted disease claim 32 , or combinations thereof.34. The method of claim 32 , wherein the rectal condition comprises hemorrhoids claim 32 , anal fissures claim 32 , a rash claim 32 , or ...

Cardiac Compression Device Having Passive And Active Chambers

The present invention provides methods, systems, kits, and cardiac compression devices that have both passive chambers and active chambers to improve heart function. 122-. (canceled)23. A method to improve diastolic recoil of a heart using a direct cardiac contact compression device comprising the steps of:providing a direct cardiac compression device, wherein the direct cardiac compression device comprises an inner passive chambers comprising an inner membrane adapted to surround the heart, a connecting membrane in communication with the inner membrane, one or more passive dividers located between the inner membrane and the connecting membrane to form inner passive chambers, and a passive fluid deposited in the inner passive chambers, wherein the inner passive chambers conform to the shape of the heart; an outer active chambers comprising an outer member in communication with the connecting membrane, one or more active dividers located between the outer member and the connecting membrane to form outer active chambers, and an active fluid disposed in the outer active chambers; an input connection in fluid communication with the outer active chambers to ingress the active fluid into the outer active chambers, and an output connection in fluid communication with the outer active chambers to egress the fluid from the outer active chambers, wherein the active fluid presses on the inner passive chambers to compress the heart;implanting the direct cardiac compression device around a heart;pressurizing the outer active chambers to expand the outer active chamber;applying force to the inner passive chambers to compress the inner membrane which selectively compresses the heart;depressurize the outer active chambers during recoil to contract the inner passive chambers and move the inner membrane away from the heart.24. The method of claim 23 , further comprising the step of connecting a pneumatic driver to the input connection and the output connection to pressurize the outer ...

LED driver circuit and method

An LED driver circuit and method are disclosed where an array of light emitting diodes have a transistor connected to each respective array of light emitting diodes. A PWM controller has an input for receiving a voltage reference and an output connected to selected transistors for driving selected transistors and setting a PWM duty cycle for the selected arrays of light emitting diodes to determine the brightness of selected light emitting diodes. An oscillator is connected to the PWM controller for driving the PWM controller.

Compositions for inhibiting inflammation in a subject with a spinal cord injury and methods of using the same

Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-a signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed.

Improved machine for treatment of an agricultural field

Compositions for treating acute, post-operative, or chronic pain and methods of using the same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.

Compositions for treating acute, post-operative, or chronic pain and methods of using the same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.

Heteroaryl compounds

The invention relates to a method of treatment of disorders and diseases associated with NPY receptor subtype Y5 comprising administering to a warm-blooded animal, including man, in need of such treatment a therapeutically effective amount of a compound of formula (I) in which the variables are as defined and relates to new compounds of formula (I) or a salt thereof, to pharmaceutical compositions, and to the manufacture of new compounds of formula (I) and salts thereof.

Compositions and methods for preventing and treating conditions

2-amino quinazoline derivatives as npy receptor antagonists

The invention relates to a compound of formula (I) in which the variables are as defined and or a salt or a tautomer thereof; and relates to a method of treatment of disorders or diseases associated with NPY receptor subtype Y5, to pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and to the manufacture of the compounds of formula (I) or a salt thereof.

Synchronous rectifier circuit capable of working as a high-efficiency DC/DC converter

A synchronous rectifier circuit operates as a high-efficiency DC/DC converter for mixed step-up/step-down applications, and includes an input terminal receiving a voltage signal, a second input terminal node connected to an external inductor, and an output terminal. A power switch may be connected between the second input terminal node and the output terminal to generate on its output a voltage at one terminal of the inductor. A driver circuit is provided for driving the power switch, and a comparator senses the potential difference between the output and input terminals and produces an enable signal for the driver circuit. The comparator may be a wide pass-band comparator forcing prompt triggering of the regulation loop in the rectifier.

Improved machine for the treatment of an agricultural field

Máquina (100) para el tratamiento de un campo (303) de agricultura, en particular para preparar el suelo para la siembra, estando la máquina (100) remolcada por un tractor (200), que comprende: - una estructura de soporte, que tiene una parte frontal que se eleva y se conecta a un tractor (200), y una parte posterior que se baja directamente al suelo (303) que va a tratarse, teniendo dicha estructura un eje longitudinal horizontal que está inclinado; - una serie de árboles (101a, 101b, ..., 101f) rotatorios conectados a dicha estructura de soporte, cada uno paralelo al otro y colocados según el mismo eje inclinado de la estructura, que tienen sus extremos frontales unidos a engranajes (107a, 107b, ..., 107f) respectivos conectados a una fuente de alimentación en el motor del tractor (200) que proporciona una fuente de energía rotativa, y que tienen sus extremos posteriores conectados a herramientas (105a, 105b, ..., 105f) de funcionamiento respectivas colocadas de una manera coaxial y concéntrica con respecto a los propios árboles (101a, 101b, ..., 101f) rotatorios, de modo que las propias herramientas (105a, 105b, ..., 105f) de funcionamiento están montadas en la parte inferior de la estructura y están en contacto con el suelo (302); dichas herramientas (105a, 105b, ..., 105f) de funcionamiento tienen una simetría radial y comprenden algunas paletas rotativas que entran en contacto radial y profundamente con el suelo (302), de modo que el paso de la máquina (100) consigue romper los terrones en trozos pequeños de manera muy eficaz, hasta que se desmenuzan para dar una granularidad muy fina, caracterizada porque comprende además: - medios (110) de guiado y/o elevación, conectados a dicha estructura de soporte de la máquina (100), que incluyen una o más ruedas, deslizadores o cilindros, y una o más varillas telescópicas con un mecanismo que bloquea la altura desde el terreno, de modo que dichas ruedas, deslizadores o cilindros permiten que disminuya la fricción que ...

Device for the modulation of cardiac end diastolic volume

The present invention provides methods, systems, kits and devices that reduce dyskinesis and hypokinesis. For example, the direct compression cardiac device may be positioned about at least a portion of a heart, and includes a resilient inner panel in contact with at least a portion of the heart periphery, one or more resilient members positioned about the resilient inner panel and at least partially surrounded by an expandable outer panel. The resistance supplied by the inner panel to the heart may be modulated to control the end-diastolic heart volume and remodel the heart, the resistance supplied by the expandable outer panel to the heart may be modulated to control the end-systolic heart volume and remodel the heart or both.

Biphasic and dynamic adjustable support devices and methods with assist and recoil capabilities for treatment of cardiac pathologies

The present invention provides a direct cardiac contact device adapted to be implanted in a patient suffering from congestive heart failure and related cardiac pathologies, said cardiac device having means for providing ventricular assist, ventricular support and diastolic recoil, or for providing ventricular support and diastolic recoil only.

Method of purifying titanium diboride

Co-current vapor-liquid contacting apparatus

The invention is a high capacity and high efficiency co-current vapor-liquid contacting apparatus for use in distillation columns and other vapor-liquid contacting processes. The apparatus is characterized by an arrangement of modules in horizontal stages rather than tray-like construction. The modules define a co-current contacting volume and in an exemplary configuration the modules include a liquid distributor, a demister, a receiving pan and a duct. The modules of one stage are rotated to be non-parallel with respect to the modules of an inferior stage, a superior stage, or both. Variations relate to the design of the individual elements such as the demister, liquid distributor, ducts, and contacting volumes, and the overall arrangement of the apparatus.

compositions and methods for preventing and treating conditions

A presente invenção refere-se a composições compreendendo uma emulsão estável de água em silicone, métodos e kits compreendendo as composições para tratamento de condições. The present invention relates to compositions comprising a stable water-in-silicone emulsion, methods and kits comprising compositions for treating conditions.

Improved machine for treatment of an agricultural field

Self-expanding heart assist device

The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart.

Compositions for inhibiting inflammation in a subject with a spinal cord injury and methods of using the same.

Se proporcionan en la presente composiciones para inhibir la inflamación en un sujeto con lesión de médula espinal que comprenden uno o más agentes capaces de reducir específicamente la señalización de TNF-a y un portador biodegradable. Se proporcionan además en la presente composiciones para inhibir la inflamación en un sujeto con lesión de médula espinal que comprenden uno o más agentes capaces de modular la señalización de MCP-1 y un portador biodegradable. También se describen métodos para tratar la inflamación en un sujeto que tiene una lesión de la médula espinal y equipos para producir las composiciones.

Compositions for an injectable, in situ forming neuroscaffold and methods of using the same

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

Compositions for an injectable, in situ forming neuroscaffold and methods of using the same

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

Carbonaceous fabric laminate

A lightweight refractory thermal insulator is provided. Superposed layers of carbonaceous fabric are cemented together to form a laminate which, because of its low weight, structural integrity, and excellent thermal resistance, is useful as thermal insulation in a variety of applications. If desired, a thin uniform film or coating of carbon black may be interspersed between the layers of carbonaceous fabric in order to impart improved thermal properties to the laminate.

COMPARATOR CIRCUIT FOR POSITIVE AND NEGATIVE SIGNALS, WITH CONSUMPTION, SUITABLE FOR SINGLE POSITIVE POWER SUPPLIES

Compositions for an injectable, in situ forming neuroscaffold and methods of using the same

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

Fully implantable direct cardiac and aortic compression device

The present invention provides a combined direct cardiac compression and aortic counterpulsation device comprising: an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.

Formulation for acidic wet chemical etching of silicon wafers

Acid etch compositions for etching multicrystalline silicon substrates are disclosed which may include hydrofluoric acid, an oxidizer, an acid diluent, and soluble silicon. The soluble silicon may be hexafluorosilicic acid or ammonium fluorosilicate. Silicon substrates patterned with organic resist may be used with the acid etch compositions for selective silicon patterning for solar cell applications.

Compositions for inhibiting inflammation in a subject with a spinal cord injury and methods of using the same

Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-α signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed.

Co-current vapor-liquid contacting apparatus

Device for the modulation of cardiac end diastolic volume

The present invention provides methods, systems, kits and devices that reduce dyskinesis and hypokinesis. For example, the direct compression cardiac device may be positioned about at least a portion of a heart, and includes a resilient inner panel in contact with at least a portion of the heart periphery, one or more resilient members positioned about the resilient inner panel and at least partially surrounded by an expandable outer panel. The resistance supplied by the inner panel to the heart may be modulated to control the end-diastolic heart volume and remodel the heart, the resistance supplied by the expandable outer panel to the heart may be modulated to control the end-systolic heart volume and remodel the heart or both.

At1 receptor antagonist for the stimulation of apoptosis.

Shackle with pivot feature

A device ( 10 ) for retaining and associating an animal with a transport system during transport to and through one or more processing operations along a processing line. The device ( 10 ) includes a pivot mechanism ( 12 ) for reliably controlling the orientation of the animal during upward and downward travel on the transport system. More specifically, the device includes a lower portion ( 14 ) for retaining the animal, and an upper portion ( 16 ) for coupling with the transport system. The lower portion ( 14 ) is pivotably coupled with the upper portion ( 16 ) and movable between a rearward position in which the lower portion ( 14 ) and the upper portion ( 16 ) are in a substantially straight orientation relative to each other, and a forward position in which the lower portion ( 14 ) and the upper portion ( 16 ) are in a substantially angled orientation relative to each other in the forward direction.

Step-up continuous mode DC-to-DC converter with integrated fuzzy logic current control

A step-up continuous-mode DC-to-DC converter with integrated current control, comprising a comparator for comparing a voltage signal output from the converter and a reference signal for generating an error signal and circuitry for generating a compensation ramp which generates a ramp signal which is added to a signal which is proportional to a current ramp that flows across the converter. The signal output from the comparator and the signal obtained from the sum are sent to an additional comparator, the output whereof, together with an oscillator signal, is used for driving a power transistor of the converter. A fuzzy logic control unit is interposed between the comparator and the additional comparator, the fuzzy logic control unit receiving at its input the error signal output by the comparator and emitting in an output signal which depends on the variation of the error signal over time to be sent to the additional

2-amino quinazoline derivatives as npy receptor antagonists

The invention relates to a compound of formula (I) in which the variables are as defined and or a salt or a tautomer thereof; and relates to a method of treatment of disorders or diseases associated with NPY receptor subtype Y5, to pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and to the manufacture of the compounds of formula (I) or a salt thereof.

Device for proactive modulation of cardiac strain patterns

A direct cardiac assist device which may aid in ventricular recovery. The device proactively modulates cardiac strain pattern to produce a contraction strain pattern that induces beneficial growth and remodeling of the myocardium or prevents or reduces apoptosis of the myocytes. The device may include an outer shell. membrane, or mesh and an inner membrane. The space between the outer member and the membrane may be filled with fluid that is pressurized during contraction. The device prescribes a beneficial strain pattern during heart contraction. This strain pattern does not invert the curvatures or grossly alter the curvatures of the heart and may assist in myocyte regrowth and healing of the failing heart.

Heteroaryl compounds

Device for proactive modulation of cardiac strain patterns

A direct cardiac assist device which may aid in ventricular recovery. The device proactively modulates cardiac strain pattern to produce a contraction strain pattern that induces beneficial growth and remodeling of the myocardium or prevents or reduces apoptosis of the myocytes. The device (10) may include an outer shell (12). membrane, or mesh and an inner membrane. The space between the outer member and the membrane may be filled with fluid (22) that is pressurized during contraction. The device prescribes a beneficial strain pattern during heart contraction. This strain pattern does not invert the curvatures or grossly alter the curvatures of the heart and may assist in myocyte regrowth and healing of the failing heart.

Compositions for an injectable, in situ forming neuroscaffold and methods of using the same

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

composition for treating acute, postoperative or chronic pain in an individual, method for treating an individual having acute, postoperative or chronic pain and kit for producing the composition

são providas aqui composições para tratar dor aguda, crônica, ou pós-operatória em um indivíduo, ditas composições compreendendo um agente anticonvulsivo e um veículo biodegradável, sendo que o agente é incorporado dentro do veículo biodegradável. métodos para tratamento de dor em um indivíduo e kits para produção das composições para tratamento de dor aguda, crônica ou dor pós-operatória em um indivíduo também estão descritos aqui. Compositions are provided herein for treating acute, chronic, or postoperative pain in an individual, said compositions comprising an anticonvulsant agent and a biodegradable carrier, the agent being incorporated into the biodegradable carrier. Methods for treating pain in an individual and kits for producing compositions for treating acute, chronic or postoperative pain in an individual are also described herein.

Compositions for treating acute, post-operative, or chronic pain and methods of using the same

Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.

Method and apparatus for product attribute measurement and gripper devices

Apparatus (28) for picking up an object (13, 20) and measuring an attribute (weight, temperature, color, etc.) of the object while being transported from one conveyor (12) to another (40). In one embodiment the objects (13, 20) are grasped by a vacuum head (22) and the weight is determined by passing vacuum head (22) and its associated cam follower (86) over a cam (84) placed on a load cell (82). A computer (38) sorts the measured objects (20) into storage containers (A-H) based on the measured attribute by activating deflecting arms (42). A method for tarring the system is also disclosed. In some embodiments the objects (13, 20) are grasped by piercing probes such as an expandable needle (34), barbed needle (37), or screw (534), or are else clamped by tweezers (334) or a gear & fingers combination (635). In a final embodiment, an item is grasped by being frozen to a temperature controllable surface. Attribute of objects can also be determined by using a camera to capture a shape of the conveyed objects (20) for comparison to the reference files in the computer (38), a device for measuring the reflectance of the conveyed objects (20), a colorimeter, or a temperature sensor.

Cardiac Compression Device Having Passive and Active Chambers

The present invention provides a direct cardiac compression device for individualized support at different locations around the heart, the device comprising: a housing shaped to conform to the shape of the heart and to surround the heart; two or more active chambers positioned adjacent to the housing, wherein the two or more active comprise one or more right active chambers positioned on the right ventricle side of the heart and one or more left active chambers positioned on the left ventricle side of the heart, wherein the two or more active chambers are designed to conform to the shape of the heart, each active chamber comprising an inner membrane sealingly attached along its periphery to the housing and an active fluid individually supplied thereto; a right input connection in fluid communication with the one or more right active chambers to ingress the active fluid into each of the one or more right active chambers; a left input connection in fluid communication with the one or more left active chambers to ingress the active fluid into each of the one or more left active chambers, and a driver in fluid communication with each of the right input connection and the left input connection to individually and periodically ingress and egress the active fluid therefrom, wherein the active fluid individually inflates the one or more right active chambers and the one or more left active chambers to compress the heart.

Device for the modulation of cardiac end diastolic volume

The present invention provides methods, systems, kits and devices that reduce dyskinesis and hypokinesis. For example, the direct compression cardiac device may be positioned about at least a portion of a heart, and includes a resilient inner panel in contact with at least a portion of the heart periphery, one or more resilient members positioned about the resilient inner panel and at least partially surrounded by an expandable outer panel. The resistance supplied by the inner panel to the heart may be modulated to control the end-diastolic heart volume and remodel the heart, the resistance supplied by the expandable outer panel to the heart may be modulated to control the end-systolic heart volume and remodel the heart or both.

Compositions and methods for preventing and treating conditions.

En el presente documento se proporcionan composiciones que comprenden una emulsión estable de agua en silicona, y métodos y kits que comprenden las composiciones para tratar afecciones.

Minimizing security scanning induced network disruptions

A method for minimizing scan disruptions includes receiving a scan request requesting to scan a set of network-connected assets. Each network-connected asset is associated with corresponding network characteristics. The method includes partitioning the set of network-connected assets into a plurality of groups based on the corresponding network characteristics. For each respective group, simultaneously, the method includes determining an ordered list for scanning each network-connected asset in the respective group, scanning a first network-connected asset of the respective group based on the ordered list, and, after scanning the first network-connected asset, determining a post-scan health status of the first network-connected asset. The method includes determining, using the post-scan health status, that a health of the first network-connected asset is degraded. The method also includes, in response to determining that the health of the first network-connected asset is degraded, halting scanning of further network-connected assets in the respective group.

Minimizing production disruption through a scan rule engine

This technology is directed to a rules based engine for managing network-based scanning of devices on a network to minimize disruptions to the network. One or more processors may identify an initial group of network devices from a set of network devices, the initial group of network devices being identified in accordance with a rule set, and initiate a scan of the initial group of network devices. The one or more processors may determine, in accordance with the rule set, an additional group of network devices from the set of network devices to be scanned and initiate a scan of the additional group of network devices. The steps may be repeated until all network devices in the set of network devices are scanned in accordance with the rule set.

Mechanisms for minimally invasive implantation of heart contacting cardiac devices

At1 rezeptor antagonist zur anregung von apoptosis

Gasgeneratorbaugruppe für ein Airbagmodul

Die Erfindung betrifft eine Gasgeneratorbaugruppe für ein Airbagmodul eines Kraftfahrzeugs, mittels der zum Befüllen eines Gassacks Gas freisetzbar ist, mit einer ersten Gasgeneratorstufe (2), durch deren Zündung ein erstes Gasvolumen freisetzbar ist, und einer zweiten Gasgeneratorstufe (3A; 3B; 3C), durch deren Zündung ein zweites Gasvolumen freisetzbar ist und die ein Gehäuse (30A; 30B; 30C) umfasst, das eine Druckkammer (31A; 31B; 31C) zur Aufnahme und/oder Erzeugung von Gas ausbildet. Dabei ist vorgesehen, dass das Gehäuse (30A; 30B; 30C) der zweiten Gasgeneratorstufe (3A; 3B; 3C) zumindest einen verformbaren Abschnitt (301; 302; 303) aufweist, an dem zumindest eine Abströmöffnung (300) ausgebildet ist und der durch Zündung der zweiten Gasgeneratorstufe (3A; 3B; 3C) von einem ersten Zustand, in dem die Abströmöffnung (300) verschlossen ist, in einen zweiten Zustand verformbar ist, in dem die Abströmöffnung (300) zum Abströmen von Gas aus der Druckkammer (31A; 31B; 31C) freigegeben ist.

Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo.

En este documento se proporcionan, entre otras cosas, la fabricación biológica y los procesos de purificación corriente abajo.

Automatic Vulnerability Mitigation in Cloud Environments

A method for implementing a migration action for a vulnerability includes receiving an indication that a target resource includes a vulnerability where the target resource is being hosted in a cloud environment and associated with a user of the cloud environment. The method also includes receiving a plurality of rules configured to mitigate vulnerabilities for cloud environment resources. The method further includes determining whether the plurality of rules include one or more rules corresponding to the vulnerability of the target resource. When the plurality of rules comprises the one or more rules corresponding to the vulnerability of the target resource, the method includes applying a reversible mitigation action associated with a respective rule of the one or more rules corresponding to the vulnerability of the target resource.

Composiciones y metodos para prevenir y tratar afecciones.

En el presente documento se proporcionan composiciones que comprenden una emulsión estable de agua en silicona, y métodos y kits que comprenden las composiciones para tratar afecciones.

Automatic vulnerability mitigation in cloud environments

A method for implementing a migration action for a vulnerability includes receiving an indication that a target resource includes a vulnerability where the target resource is being hosted in a cloud environment and associated with a user of the cloud environment. The method also includes receiving a plurality of rules configured to mitigate vulnerabilities for cloud environment resources. The method further includes determining whether the plurality of rules include one or more rules corresponding to the vulnerability of the target resource. When the plurality of rules comprises the one or more rules corresponding to the vulnerability of the target resource, the method includes applying a reversible mitigation action associated with a respective rule of the one or more rules corresponding to the vulnerability of the target resource.

Minimizing production disruption through a scan rule engine

This technology is directed to a rules based engine for managing network-based scanning of devices on a network to minimize disruptions to the network. One or more processors may identify an initial group of network devices from a set of network devices, the initial group of network devices being identified in accordance with a rule set, and initiate a scan of the initial group of network devices. The one or more processors may determine, in accordance with the rule set, an additional group of network devices from the set of network devices to be scanned and initiate a scan of the additional group of network devices. The steps may be repeated until all network devices in the set of network devices are scanned in accordance with the rule set.

Direct Cardiac Compression Device with Improved Durability

The present invention provides a direct cardiac compression device comprising one or more passive chambers that taper from an aperture to an apex; one or more inflatable active pockets individually independently inflatable, wherein each of the one or more inflatable active pockets is connected to the one or more passive chambers at least partially from the aperture to the apex and wherein the each of the one or more inflatable active pockets does not tension the adjacent one or more inflatable active pockets upon inflation; and a frame in contact with the one or more active chambers to at least partially surround the one or more active pockets.

Dispositivo e metodo di codifica e decodifica per la compressione edecompressione di dati digitali.

Shackle with pivot feature and log chain drive mechanism

A device for retaining an animal on a transport system for moving the animal in a forward direction includes a lower portion operable to retain the animal and an upper portion operable for conveyance by the transport system. The upper portion is attachable to the lower portion, and the upper portion includes a connector for connecting the device to a drive mechanism. The connector has a longitudinal axis. The lower portion is operable for movement between a first position in which a longitudinal axis of the lower portion and the longitudinal axis of the connector are in substantially straight orientation relative to each other, and a second position wherein the longitudinal axis of the lower portion and the longitudinal axis of the connector are in substantially angled orientation relative to one another. The lower portion is substantially inhibited from moving in a rearward direction beyond said first position.

Process technology for biological product manufacturing and downstream purification

conjunto de engate de separaÇço removÍvel

Patente de Invenção: CONJUNTO DE ENGATE DE SEPARAÇçO REMOVÍVEL. A presente invenção refere-se a um conjunto de engate de separação removível para suspender uma carcaça de animal durante o processamento que inclui um engate conectado a uma barra pendente, onde a barra pendente está conectada a um sistema transportador. A barra pendente inclui um corpo alongado com um conector em uma extremidade. O engate inclui braços opostos dobráveis que formam um espaço alargável. O engate é separável da barra pendente através do espaço alargável fazendo com que os braços dobrem e o espaço alargue, ou passando o espaço alargável através de uma depressão na barral pendente.

Picker apparatus and method for defeathering poultry

A picker apparatus for defeathering or plucking of poultry and other avian in a food processing facility includes a universal mount picker assembly (300) including a belt drive system (307) for driving a plurality of rotatable picker members (303) with a drive motor (305) disposed centrally in relation to the picker members (303), and a quick release positioning adjustment (208) for the operating components of a picker apparatus.

Process technology for biological product manufacturing and downstream purification

Provided herein are,

Process technology for biological product manufacturing and downstream purification

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Process technology for biological product manufacturing and downstream purification

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Process technology for biological product manufacturing and downstream purification

Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Attrezzo di supporto a canna da pesca in grado di garantire l'agganciamento automatico della preda mediante impennaggio rapido