METHODS AND APPARATUS FOR REDUCING VOIDS IN A MOLDED PART

Methods and apparatus for a mold assembly to minimize voids in a molded product. The mold assembly can include a fill port aligned in relation to first surface feature of a part to be molded, a vent to provide an exit passage for bubbles associated with a second surface feature, and a fill angle scheme to minimize voids in the molded part. 1. A method , comprising:having the mold assembly positioned to a first orientation when the mold assembly is filled at a first amount; andhaving the mold assembly positioned to a second orientation when the mold assembly is filled to a second amount,wherein manipulating the mold assembly to the first and second orientations produces less bubbles associated with a first surface feature than if the mold assembly was not manipulated into the first and second orientations, the first surface feature corresponding to a feature on a part to be molded that can accumulate bubbles in a fill material as a mold of the mold assembly is filled with the fill material.2. The method according to claim 1 , wherein the first surface feature includes an overhang on a surface of the part.3. The method according to claim 1 , wherein the first surface feature includes an overhang formed by a cap.4. The method according to claim 1 , further including a fill port for the mold assembly claim 1 , wherein the part includes a second surface feature that is substantially elongate with a longitudinal axis claim 1 , wherein a direction of flow material from the fill port is generally parallel to the longitudinal axis of the second surface feature.5. The method according to claim 4 , wherein the second surface feature includes a wire and the fill port is substantially parallel to the direction of flow material from the fill port.6. The method according to claim 1 , further including a locating a vent in the mold assembly in relation to the first surface feature to provide an exit path for the bubbles created by the first surface feature.7. The method according ...

Dislocation Engineering Using a Scanned Laser

A method for generating patterned strained regions in a semiconductor device is provided. The method includes directing a light-emitting beam locally onto a surface portion of a semiconductor body; and manipulating a plurality of dislocations located proximate to the surface portion of the semiconductor body utilizing the light-emitting beam, the light-emitting beam being characterized as having a scan speed, so as to produce the patterned strained regions. 1. A system for manipulating dislocations on semiconductor devices , comprising:a moveable laser configured to generate a laser beam locally on a surface portion of the semiconductor body having a plurality of dislocations, the moveable laser being characterized as having a scan speed, the moveable laser manipulates the plurality of dislocations on the surface portion of the semiconductor body by adjusting the temperature and the scan speed of the laser beam.2. The system as in claim 1 , wherein the moveable laser is operative to manipulate the plurality of dislocations by directly heating the plurality of dislocations with the laser beam such that the plurality of dislocations is driven away from the surface portion of the semiconductor body enabling the elimination of the plurality of dislocations on the semiconductor body.3. The system as in claim 1 , wherein the moveable laser is operative to manipulate the plurality of dislocations by scanning across the plurality of dislocations with the laser beam such that the plurality of dislocations grow over the length of the scan of the laser beam enabling the removal of threading dislocations from a relaxed layer on the semiconductor device.4. The system as in claim 3 , wherein the system is operative to affect plurality of dislocations that grow over the length of the scan of the laser beam when the scan speed of the laser beam is approximately greater than 1250 degrees Centigrade and the scan speed of the laser beam is greater than approximately 1 millisecond. ...

Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions. 1. A method of selecting a subject for treatment with a modified soluble hyaluronidase , comprising:a) measuring the expression or level of a marker associated with a hyaluronan-associated disease or condition in a sample from a subject;b) comparing the expression or level of the marker to expression or level in a control sample or standard; andc) if the marker is changed compared to the control sample or standard, selecting the subject for treatment with the modified soluble hyaluronidase, wherein modification of the soluble hyaluronidase is conjugation to a polymer.2. The method of claim 1 , wherein the marker is hyaluronan (HA) claim 1 , a hyaluronidase or a hyaluronan synthase.3. The method of claim 2 , wherein the marker is a hyaluronan synthase that is hyaluronan synthase 2 (HAS2).4. The method of claim 1 , wherein the sample in a) is selected from among a tissue claim 1 , cell and bodily fluid.5. The method of claim 4 , wherein the sample is a tumor.6. The method of claim 1 , wherein the control sample in b) is selected from among:a) an analogous sample from another subject that is a normal subject or a subject known to express low hyaluronan in the sample; andb) a cell line.7. The method of claim 1 , wherein the expression or ...

Interosmolar fluid removal

Inventions are disclosed that generate osmotic pressure that can be used to remove fluids from a patient. One embodiment involves implanting a reservoir that has a semipermeable membrane sidewall. The reservoir contains trapped osmotic solutes that can not pass out through the membrane. But fluid from the patient can flow in. The osmotic pressure from the trapped solutes in the reservoir draws fluid from the patient across the semipermeable membrane and into the device. The reservoir may optionally be recharged from time to time and/or replaced by a new reservoir.

Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions. 1. A method of selecting a subject for treatment with a modified soluble hyaluronidase , comprising:a) measuring the expression or level of a marker associated with a hyaluronan-associated disease or condition in a sample from a subject;b) comparing the expression or level of the marker to expression or level in a control sample or standard; andc) if the marker is changed compared to the control sample or standard, selecting the subject for treatment with the modified soluble hyaluronidase, wherein modification of the soluble hyaluronidase is conjugation to a polymer.2. The method of claim 1 , wherein the marker is hyaluronan (HA) claim 1 , a hyaluronidase or a hyaluronan synthase.3. The method of claim 2 , wherein the marker is a hyaluronan synthase that is hyaluronan synthase 2 (HAS2).4. The method of claim 1 , wherein the sample in a) is selected from among a tissue claim 1 , cell and bodily fluid.5. The method of claim 4 , wherein the sample is a tumor.6. The method of claim 1 , wherein the control sample in b) is selected from among:a) an analogous sample from another subject that is a normal subject or a subject known to express low hyaluronan in the sample; andb) a cell line.7. The method of claim 1 , wherein the expression or ...

Liquid crude hydrocarbon composition

Disclosed is a liquid crude hydrocarbon composition containing (a) a liquid crude hydrocarbon having an API gravity of less than or equal to about 20; and (b) a minor amount of a blend comprising (i) one or more hydrocarbon-containing solvents having an aromatic content of at least about 10 wt. %; and (ii) one or more asphaltene modifiers selected from the group consisting of an aromatic sulfonic acid or salt thereof, an aliphatic sulfonic acid or salt thereof and an alkyl-substituted hydroxyaromatic carboxylic acid or salt thereof. Also disclosed is a method for transporting a liquid crude hydrocarbon having an API gravity of less than or equal to about 20. 1. A liquid crude hydrocarbon composition comprising:(a) a liquid crude hydrocarbon having an API gravity of less than or equal to about 20; and(b) a minor amount of a blend comprising (i) one or more hydrocarbon-containing solvents having an aromatic content of at least about 10 wt. %; and (ii) one or more asphaltene modifiers selected from the group consisting of an aromatic sulfonic acid or salt thereof, an aliphatic sulfonic acid or salt thereof and an alkyl-substituted hydroxyaromatic carboxylic acid or salt thereof.2. The liquid crude hydrocarbon composition of claim 1 , wherein the liquid crude hydrocarbon having an API gravity of less than or equal to about 20 comprises a heavy crude oil.3. The liquid crude hydrocarbon composition of claim 1 , wherein the liquid crude hydrocarbon having an API gravity of less than or equal to about 20 comprises an extra heavy crude oil.4. The liquid crude hydrocarbon composition of claim 1 , wherein the liquid crude hydrocarbon having an API gravity of less than or equal to about 20 has a viscosity greater than about 100 cSt and no more than 2 claim 1 ,000 claim 1 ,000 cSt at 40° C.5. The liquid crude hydrocarbon composition of claim 1 , wherein the one or more hydrocarbon-containing solvents comprises a solvent having an aromatic content of at least about 20 wt. %.6. ...

CHIP IDENTIFICATION PADS FOR IDENTIFICATION OF INTEGRATED CIRCUITS IN AN ASSEMBLY

Chip identification pads for identification of integrated circuits in an assembly. In one example embodiment, an integrated circuit (IC) assembly includes a controller, a plurality of ICs, a shared communication bus connecting the controller to the plurality of ICs and configured to enable communication between the controller and each of the plurality of ICs, and a set of one or more chip identification pads formed on each IC. Each set of chip identification pads has an electrical connection pattern. The electrical connection pattern of each set is distinct from the electrical connection pattern on every other set. Each distinct electrical connection pattern represents a unique identifier of the corresponding IC thereby enabling the controller to distinguish between the ICs. 1. A printed circuit board assembly (PCBA) comprising:a controller;a plurality of integrated circuits (ICs);a shared communication bus connecting the controller to the plurality of ICs and configured to enable communication between the controller and each of the plurality of ICs;a set of one or more chip identification pads formed on each IC, each set of chip identification pads having an electrical connection pattern, the electrical connection pattern of each set being distinct from the electrical connection pattern on every other set, each distinct electrical connection pattern representing a unique identifier of the corresponding IC thereby enabling the controller to distinguish between the ICs.2. The PCBA as recited in claim 1 , wherein the electrical connection pattern is created by electrically placing each chip identification pad in one of two binary states.3. The PCBA as recited in claim 1 , wherein the two binary states are created by connecting each chip identification pad to a known voltage or leaving each chip identification pad unconnected.4. The PCBA as recited in claim 1 , further comprising a memory formed on each IC claim 1 , and each IC is configured to store the unique ...

COORDINATE MEASURING MACHINES WITH DUAL LAYER ARM

A portable articulated arm coordinate measuring machine (AACMM) is provided including a manually positionable articulated arm having opposed first and second ends. The arm includes multiple connected arm segments. Each arm segment has a longitudinal axis. Each arm segment includes a generally tubular core, an outer sleeve surrounding at least a portion of a length of the core, and at least one position transducer for producing a position signal. The outer sleeve is a cylindrical tube having a first portion at a first end and a second portion that extends from the first portion to an opposite end. The first portion is coupled to an end of the core. The first portion is shorter than the second portion and the second portion is configured to move relative to the core. 1. A portable articulated arm coordinate measurement machine (AACMM) , comprising:a manually positionable articulated arm having opposed first and second ends, the arm including a plurality of connected arm segments, at least one of the arm segments having a longitudinal axis and including a generally tubular composite core, an outer sleeve surrounding at least a part of a length of the composite core, and at least one position transducer for producing a position signal, wherein the outer sleeve is a cylindrical tube that includes a first portion at a third end of the outer sleeve and a second portion that extends between the first portion and a fourth end opposite the third end such that the first portion is coupled to a fifth end of the composite core, the first portion having a shorter length than the second portion and wherein the second portion is configured to move freely relative to the composite core;a measurement device attached to a first end of the AACMM; andan electronic circuit for receiving the position signal from the at least one transducer and for providing data corresponding to a position of the measurement device.2. The portable AACMM according to claim 1 , wherein the composite core ...

Soybean aphid resistance gene rag2

Provided herein are isolated nucleic acid molecules representing a genetically defined region of the genome of the aphid resistant soybean plant ( Glycine max ) cultivar PI 200538 that confers resistance to soybean aphid ( Aphis glycines ). Within the region is a gene encoding the aphid resistance protein Rag2. Also provided herein are methods for conferring aphid resistance on a plant or enhancing aphid resistance in a plant by transforming it to contain and express such nucleic acid sequences encoding Rag2 aphid resistance or introgressing DNA encoding the trait into the plant by plant breeding. Further provided are polymorphic markers useful for identifying plant germplasm containing aphid resistance, and methods for using such markers.

Combination therapy with an anti-hyaluronan agent and therapeutic agent

Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers. 1. A combination , comprising:a composition comprising an anti-hyaluronan agent; anda composition comprising a tumor-targeted taxane.2. The combination of claim 1 , wherein:the compositions are formulated for direct administration;the concentration of anti-hyaluronan agent is sufficient to degrade tumor-associated hyaluronan; andthe concentration of tumor-targeted taxane is sufficient to achieve intratumoral delivery.3. The combination of claim 1 , wherein the concentration of tumor-targeted taxane formulation is sufficient to reduce intratumoral nucleoside deaminase protein levels or protein activity compared to the levels or activity of the nucleoside deaminase in the absence of the intratumoral taxane formulation.4. The combination of claim 1 , wherein the anti-hyaluronan agent and tumor-targeted taxane are co-formulated or provided separately.5. The combination of claim 1 , further comprising a composition comprising a nucleoside analog.6. The combination of claim 5 , wherein:the composition is formulated for direct administration; andthe concentration of nucleoside analog is sufficient to achieve intratumoral delivery.7. The combination of claim 5 , wherein the nucleoside analog is provided separately from the anti-hyaluronan agent and tumor-targeted taxane.8. The combination of claim 5 , wherein the nucleoside analog is co-formulated with the anti-hyaluronan agent or is co-formulated with the tumor-targeted taxane.9. The combination of claim 5 , wherein the nucleoside analog is co-formulated with the anti-hyaluronan agent and the tumor-targeted taxane.10. The combination of claim 1 , wherein the compositions are ...

INTEGRATING MULTIPLE DATA SOURCES FOR MALWARE CLASSIFICATION

Disclosed herein are representative embodiments of tools and techniques for classifying programs. According to one exemplary technique, at least one graph representation of at least one dynamic data source of at least one program is generated. Also, at least one graph representation of at least one static data source of the at least one program is generated. Additionally, at least using the at least one graph representation of the at least one dynamic data source and the at least one graph representation of the at least one static data source, the at least one program is classified. 1. A method , implemented at least in part by one or more computing devices , the method comprising:generating at least one graph representation of at least one dynamic data source of at least one program;generating at least one graph representation of at least one static data source of the at least one program; andat least using the at least one graph representation of the at least one dynamic data source and the at least one graph representation of the at least one static data source, classifying the at least one program.2. One or more computer readable storage media storing computer-executable instructions which when executed cause a computing device to perform a method , the method comprising:generating at least one graph representation of at least one dynamic data source of at least one program;generating at least one graph representation of at least one static data source of the at least one program; andat least using the at least one graph representation of the at least one dynamic data source and the at least one graph representation of the at least one static data source, classifying the at least one program.3. The method of claim 1 , wherein the classifying the program comprises classifying the program as malware or non-malware.4. The method of claim 1 , wherein the at least one graph representation of the at least one dynamic data source or the at least one graph ...

Bicast turbine engine components

A turbine blade assembly includes a turbine blade having a pressure sidewall and an opposed suction sidewall and a first snubber assembly associated with one of the pressure sidewall and the suction sidewall. The first snubber assembly includes a first base portion extending outwardly from the one of the pressure sidewall and the suction sidewall, and a first snubber portion. The first base portion is integrally cast with the turbine blade and includes first connection structure. The first snubber portion is bicast onto the first base portion and includes second connection structure that interacts with the first connection structure to substantially prevent separational movement between the first base portion and the first snubber portion.

Sensing system and method for use in electromagnetic-absorbing material

Systems and methods for obtaining telemetry environmental readings from within an electromagnetic-absorbing material are disclosed herein. The system may include a self-contained power source powering a switch-mode amplifier to drive a multi-turn coil to be driven with a low-frequency carrier.

TROCAR ASSEMBLY WITH A CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

The present disclosure relates to a trocar assembly with an integrated scope-cleaning structure. The trocar assembly may include a housing defining boundaries of a chamber with (a) a proximal opening configured to receive a distal end of a scope, and (b) a distal opening in fluid and mechanical communication with a trocar cannula. The trocar assembly may further include a cleaning element located at least partially between the proximal opening and the distal opening, where the cleaning element is movable with respect to the housing from at least a first setting where a first portion of the cleaning element may be in a first location and may form a first cleaning surface within the chamber, the first cleaning surface configured to remove debris from a distal end of the scope when the distal end of the scope contacts the first portion of the cleaning element. 1. A method for cleaning a scope , the method comprising:maneuvering a distal end of the scope to a position within a housing, which housing includes a distal opening in fluid communication with a trocar cannula, wherein the housing is coupled to a rotatable wheel having a first cleaning surface and a wheel opening, said first cleaning surface and said wheel opening longitudinally alignable with a longitudinal axis through the trocar cannula and the distal opening;contacting a cleaning surface of the rotatable wheel with a distal end surface of the scope while the rotatable wheel is in a first setting, wherein in the first setting, the first cleaning surface is longitudinally aligned with the distal opening of the housing;rotating the rotatable wheel to a second setting; andpassing a distal end of a scope distally through and the distal opening of the housing.2. The method of claim 1 , wherein in the second setting claim 1 , an opening of the rotatable wheel is longitudinally aligned with the distal opening of the housing such that the distal end of the scope readily passes longitudinally distally through the ...

Coupling Polymeric Components to One Another Utilizing Electromagnetic Energy

A method of coupling polymeric components utilizing electromagnetic energy is disclosed. The method can include obtaining a first component having a first coupling portion, a second component having a second coupling portion, and a susceptor. The method can also include mating the first and second components such that the susceptor is proximate the first and second coupling portions. In addition, the method can include applying electromagnetic energy to the susceptor. The susceptor can convert the electromagnetic energy to heat, which can melt portions of the first and second coupling portions about the susceptor to couple the first and second components to one another upon solidification.

Fixation for implantable medical devices

A tine portion of an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from a distal end of the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, for example, defined by a single radius, preferably tapers from a first width thereof, in proximity to a proximal end thereof, to a smaller, second width thereof, in proximity to the distal end thereof, wherein the tip has a width that is greater than the second width of the hook segment. Alternately, the tine portion may include a hook segment that is defined by two radii and a straight section extending therebetween.

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE IMAGING

When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital focal plane array (DFPA) with one or more m-bit counters can produce an image whose dynamic range is greater than the native dynamic range. In one example, the DFPA acquires a first image over a relatively brief integration period at a relatively low gain setting. The DFPA then acquires a second image over longer integration period and/or a higher gain setting. During this second integration period, counters may roll over, possibly several times, to capture a residue modulus m of the number of counts (as opposed to the actual number of counts). A processor in or coupled to the DFPA generates a high-dynamic range image based on the first image and the residues modulus m.

Air filter cartridges; air cleaner assemblies; housings; features; components; and, methods

According to the present disclosure, features, components and techniques useable for providing air cleaner arrangements are provided. Many of the features relate to an axial seal arrangement provided on a filter cartridge. A typical filter cartridge, for use with these features, is a filter cartridge having opposite flow ends. Example media arrangements that fit this characterization are described. Seal arrangements provided with an axial housing sealing engagement surface are shown. A seal arrangement is provided with variations therein, to advantage. These variations can be in both of an outer peripheral edge surface and a housing seal engagement surface. Also, air cleaner assemblies having advantageous features therein are provided. Further, air cleaner housings are described, with selected, preferred features for engagement with filter cartridges.

COMBINATION THERAPY WITH A HYALURONAN-DEGRADING ENZYME AND AN IMMUNE CHECKPOINT INHIBITOR

Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided. 1. A method for treating a cancer , comprising:administering a first composition comprising a soluble hyaluronidase, wherein the soluble hyaluronidase is conjugated to a polymer, or is formulated for slow release or is encoded in an oncolytic vector; andadministering a second composition comprising an immune checkpoint inhibitor, wherein:the hyaluronidase is administered simultaneously, sequentially or intermittently with the immune checkpoint inhibitor or in the same composition; andthe immune checkpoint inhibitor is an anti-CTLA4, anti-PD-1 or anti-PD-L1 antibody or antigen binding fragment thereof.2. The method of claim 1 , wherein the compositions are administered systemically.3. The method of claim 1 , wherein the compositions are administered intravenously.4. The method of claim 1 , wherein the soluble hyaluronidase is conjugated to a polymer.5. The method of claim 4 , wherein the polymer is a PEG moiety claim 4 , whereby the hyaluronidase is pegylated.6. The method of claim 1 , wherein the soluble hyaluronidase is administered at least or at least about or about or 5 minutes claim 1 , 15 minutes claim 1 , 30 minutes claim 1 , 1 hour claim 1 , 2 hours claim 1 , 3 hours claim 1 , 4 hours claim 1 , 6 hours claim 1 , 8 hours claim 1 , 12 hours claim 1 , 16 hours claim 1 , 18 hours claim 1 , 20 hours claim 1 , 22 hours claim 1 , 24 hours claim 1 , 30 hours claim 1 , 36 hours claim 1 , 40 hours or 48 hours prior to administration of the immune checkpoint inhibitor.7. The method of claim 1 , wherein the cancer comprises a solid tumor.8. The method of claim 7 , wherein:the tumor is determined to have moderate to high hyaluronan content or high hyaluronan content;moderate content is ...

HIGH MEMORY BANDWIDTH NEUROMORPHIC COMPUTING SYSTEM

Three-dimensional (3D) neuromorphic computing systems are provided. A system includes a logic wafer having a plurality of processors. The system further includes a double-sided interposer bonded to the logic wafer and incorporating a signal port ring for sending and receiving signals. The system also includes a plurality of 3D memory modules bonded to the double-sided interposer. The double-sided interposer is a wafer scale or a panel scale providing communication between the plurality of processors and the plurality of 3D memory modules. 1. A three-dimensional (3D) neuromorphic computing system , comprising:a logic wafer having a plurality of processors;a double-sided interposer bonded to the logic wafer, and incorporating a signal port ring for sending and receiving signals; anda plurality of 3D memory modules bonded to the double-sided interposer,wherein the double-sided interposer is a wafer scale or a panel scale providing communication between the plurality of processors and the plurality of 3D memory modules.2. The 3D neuromorphic computing system of claim 1 , wherein the double-sided interposer comprises Si or glass or a flexible material.3. The 3D neuromorphic computing system of claim 1 , wherein the double-sided interposer is formed into a rectangular shape.4. The 3D neuromorphic computing system of claim 1 , wherein the double-sided interposer comprises one or more switches for power island control selected from the group consisting of microelectromechanical switches and nanoelectromechanical switches.5. The 3D neuromorphic computing system of claim 1 , further comprising a plurality of power modules disposed amongst the plurality of 3D memory modules.6. The 3D neuromorphic computing system of claim 5 , wherein the logic wafer comprises a plurality of fully integrated voltage regulators for connecting to plurality of power modules.7. The 3D neuromorphic computing system of claim 6 , further comprising a printed circuit board for distributing power to the ...

SOLVENT EXTRACTION FOR PREPARING A SALT OF A SULFURIZED ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOSITION

Disclosed is a process for preparing a salt of a sulfurized alkyl-substituted hydroxyaromatic composition having a reduced content of unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt. The process involves at least the steps of: (a) providing a composition comprising (i) a salt of a sulfurized alkyl-substituted hydroxyaromatic compound; (ii) an unsulfurized alkyl-substituted hydroxyaromatic compound and (iii) an unsulfurized metal salt of the alkyl-substituted hydroxyaromatic compound; wherein the alkyl-substituted hydroxyaromatic compound is derived from alkylation of a hydroxyaromatic compound with one or more olefins comprising Cto Coligomers of monomers selected from propylene, butylene or mixtures thereof; and (b) extracting the unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt from the composition of step (a) with one or more solvents capable of solubilizing the unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt and under extraction conditions sufficient to provide a salt of a sulfurized alkyl-substituted hydroxyaromatic composition having a reduced content of unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt. 1. A process for preparing a salt of a sulfurized alkyl-substituted hydroxyaromatic composition having a reduced content of unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt , the process comprising the steps of:{'sub': 9', '18, '(a) providing a composition comprising (i) a salt of a sulfurized alkyl-substituted hydroxyaromatic compound; (ii) an unsulfurized alkyl-substituted hydroxyaromatic compound and (iii) an unsulfurized metal salt of the alkyl-substituted hydroxyaromatic compound; wherein the alkyl-substituted hydroxyaromatic compound is derived from alkylation of a hydroxyaromatic compound with one or more olefins comprising Cto Coligomers of monomers selected ...

COMPUTATIONAL METHOD FOR FEEDBACK IN A HIERARCHICAL NEURAL NETWORK

Feedback within hierarchical neural networks such as hierarchical temporal memories is provided. In various embodiments, a plurality of input streams is received at a first region of a hierarchical artificial neural network. The plurality of input streams is pooled in the first region. One or more recurrent features are identified in the pooled input streams in the first region. A temporal pattern is recognized in the one or more recurrent features in the first region. An indication of the temporal pattern is provided to at least a second region of the hierarchical neural network. A response to a further input is modulated based on feedback from the second region and at least one additional region. 1. A method , comprising:identifying one or more recurrent features in an input stream in a first region of a hierarchical artificial neural network;recognizing a temporal pattern in the one or more recurrent features in the first region;providing to at least a second region of the hierarchical neural network an indication of the temporal pattern; andmodulating a response to a further input to the first region based on feedback from the second region and at least one additional region.2. The method of claim 1 , wherein the input stream is a pooled input stream claim 1 , the method further comprising:receiving a plurality of input streams at the first region; andpooling the plurality of input streams to form the input stream in the first region.3. The method of claim 1 , wherein the feedback from the second region is based on a stable representation within the second region.4. The method of claim 3 , wherein the stable representation is based on prior input to the hierarchical artificial neural network.5. The method of claim 1 , further comprising:providing to at least a third region of the hierarchical neural network an indication of the one or more recurrent features.6. The method of claim 1 , wherein said providing the indication of the temporal pattern comprises ...

SELF-ADJUSTING THRESHOLD FOR SYNAPTIC ACTIVITY IN NEURAL NETWORKS

Self-adjusting thresholds for synaptic activity in neural networks are provided. In various embodiments, for each of a plurality of neurons within an artificial neural network, an overlap value is determined corresponding to active inputs connected to the neuron via synapses having non-zero synaptic weights. A count of those of the plurality of neurons whose overlap exceeds an activation threshold of the neural network is determined. The count is compared to a predetermined neuronal activity target. The activation threshold of the neural network is adjusted to approach the predetermined neuronal activity target. 1. A method , comprising:for each of a plurality of neurons within an artificial neural network, determining an overlap value corresponding to active inputs connected to the neuron via synapses having non-zero synaptic weights;determining a count of those of the plurality of neurons whose overlap exceeds an activation threshold of the neural network;comparing the count to a predetermined neuronal activity target; andadjusting the activation threshold of the neural network to approach the predetermined neuronal activity target.2. The method of claim 1 , wherein adjusting the threshold comprises:decrementing the threshold when the count is less than the predetermined neuronal activity target.3. The method of claim 1 , wherein the threshold is predetermined.4. The method of claim 1 , wherein determining the overlap value comprises applying synaptic weights to the inputs.5. The method of claim 4 , wherein said applying the synaptic weights to the inputs comprises multiplication of the synaptic weights by the inputs and summation of the results thereof.6. The method of claim 4 , wherein the synaptic weights are binary.7. The method of claim 1 , wherein each of the plurality of neurons is within one layer of the artificial neural network.8. The method of claim 1 , wherein each of the plurality of neurons is within one spatial region of the artificial neural ...

DISLOCATION ENGINEERING USING A SCANNED LASER

A method for generating patterned strained regions in a semiconductor device is provided. The method includes directing a light-emitting beam locally onto a surface portion of a semiconductor body; and manipulating a plurality of dislocations located proximate to the surface portion of the semiconductor body utilizing the light-emitting beam, the light-emitting beam being characterized as having a scan speed, so as to produce the patterned strained regions. 1. A method for manipulating dislocations from a semiconductor device , comprising:directing a light-emitting beam locally onto a surface portion of a semiconductor body that includes active regions of the semiconductor device; andmanipulating a plurality of dislocations located proximate to the surface portion of the semiconductor body utilizing the light-emitting beam,wherein manipulating the plurality of dislocations comprises directly scanning the plurality of dislocations with the light-emitting beam to manipulate a location of each of the plurality of dislocations on the surface portion of the semiconductor body by adjusting a temperature of the surface portion of the semiconductor body corresponding to the plurality of dislocations and adjusting a scan speed of the laser beam.2. The method of claim 1 , wherein manipulating the plurality of dislocations further comprises heating the plurality of dislocations with the laser beam such that the plurality of dislocations are driven away from the surface portion of the semiconductor body into the substrate. This is a divisional application of application Ser. No. 13/372,713, filed Feb. 14, 2012 which is a divisional application of application Ser. No. 12/242,990, filed Oct. 1, 2008 and assigned U.S. Pat. No. 8,138,066, dated Mar. 20, 2012.This invention relates to a system and method for manipulating dislocations in semiconductor devices using a scanned laser.Currently, 65 nanometer (nm) technology and beyond makes extensive use of strain engineering to optimize ...

DISLOCATION ENGINEERING USING A SCANNED LASER

A system for manipulating dislocations on semiconductor devices, includes a moveable laser configured to generate a laser beam locally on a surface portion of the semiconductor body having a plurality of dislocations, the moveable laser being characterized as having a scan speed, the moveable laser manipulates the plurality of dislocations on the surface portion of the semiconductor body by adjusting the temperature and the scan speed of the laser beam. 1. A method for manipulating dislocations from a semiconductor device , comprising:directing a light-emitting beam locally onto a surface portion of a semiconductor body that includes active regions of the semiconductor device; andmanipulating a plurality of dislocations located proximate to the surface portion of the semiconductor body utilizing the light-emitting beam;wherein manipulating the plurality of dislocations comprises directly scanning the plurality of dislocations with the light-emitting beam to manipulate a size of the plurality of dislocations on the surface portion of the semiconductor body by adjusting a temperature of the surface portion of the semiconductor body corresponding to the plurality of dislocations and adjusting a scan speed of the laser beam.2. The method of claim 1 , wherein manipulating the plurality of dislocations further comprises scanning across the plurality of dislocations with the laser beam such that the plurality of dislocations grow over the length of a scan of the laser beam enabling the removal of threading dislocations from a relaxed strained layer on the semiconductor device. This is a divisional application of Ser. No. 13/565,018, filed Aug. 2, 2012, which is a divisional of application Ser. No. 13/372,713, filed Feb. 14, 2012, which is a divisional application of application Ser. No. 12/242,990, filed Oct. 1, 2008.This invention relates to a system and method for manipulating dislocations in semiconductor devices using a scanned laser.Currently, 65 nanometer (nm) ...

ISOMERIZED ALPHA OLEFIN SULFONATE AND METHOD OF MAKING THE SAME

The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C-Cnormal alpha olefins: and neutralizing the isomerized alpha olefin sulfonic acid with a source of an alkali metal or ammonium or substituted ammonium ion. 2. The sulfonate of wherein the aliphatic hydrocarbyl group is derived from a skeletal isomerized alpha olefin having a Branching Index (BI) from about 16 to about 27 claim 1 , a Branching Proximity (BP) from about 9 to about 34 and a Free Carbon Index (FCI) from about 2 to about 8.35.-. (canceled)6. The sulfonate of wherein M is an alkali metal or ammonium or substituted ammonium ion.7. The sulfonate of wherein M is sodium.8. The sulfonate of wherein the skeletal isomerized alpha olefin aliphatic is derived from the skeletal isomerization of Cto Cnormal alpha olefins.9. The sulfonate of wherein the skeletal isomerized alpha olefin aliphatic is derived from the skeletal isomerization of Cto Cnormal alpha olefins.10. The sulfonate of wherein the skeletal isomerized alpha olefin aliphatic is derived from the skeletal isomerization of Cto Cnormal alpha olefins. This application is a divisional of co-pending U.S. patent application Ser. No. 12/962,818 filed Dec. 8, 2010, which claims benefit of U.S. Provisional Application No. 61/289,091 filed Dec. 22, 2009, the contents of which are incorporated herein by reference.The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same.Alpha-olefins, especially those containing about 6 to about 20 carbon atoms, are important items of commerce, with about 1.5 million tons reportedly being produced in 1992. Alpha olefins are also used as intermediates in ...

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE IMAGING

When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital focal plane array (DFPA) with one or more m-bit counters can produce an image whose dynamic range is greater than the native dynamic range. In one example, the DFPA acquires a first image over a relatively brief integration period at a relatively low gain setting. The DFPA then acquires a second image over longer integration period and/or a higher gain setting. During this second integration period, counters may roll over, possibly several times, to capture a residue modulus 2of the number of counts (as opposed to the actual number of counts). A processor in or coupled to the DFPA generates a high-dynamic range image based on the first image and the residues modulus 2. 1generating, in the m-bit counter, a first count representative of detections by the detector element during a first integration period;generating, in the m-bit counter, a second count representative of detections by the detector element during a second integration period;performing a comparison of the first count to the second count;identifying motion in the scene based on the comparison of the first count to the second count; andgenerating the motion-compensated representation of the scene based at least in part on the first count and the motion in the scene, the motion-compensated representation of the scene having a bit depth greater than m bits.. A method of generating a motion-compensated representation of a scene with a detector element operably coupled to an m-bit counter, where m is a positive integer, the method comprising: This application is a continuation of U.S. application Ser. No. 15/463,590, filed Mar. 20, 2017, which is a continuation of U.S. application Ser. No. 14/995,557, now U.S. Pat. No. 9,615,038, filed Jan. 14, 2016, which is a continuation of U.S. application Ser. No. 14/261,840, now ...

Combination therapy with an anti-hyaluronan agent and therapeutic agent

Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

COMPUTATIONAL METHOD FOR TEMPORAL POOLING AND CORRELATION

A computational method is disclosed for the simulation of a hierarchical artificial neural network (ANN), wherein a single correlator pools, during a single time-step, two or more consecutive feed-forward inputs from previously predicted and now active neurons of one or more lower levels. 1. A computational method for the simulation of a hierarchical artificial neural network (ANN) , wherein a single correlator pools , during a single time-step , two or more consecutive feed-forward inputs from previously predicted and now active neurons of one or more lower levels.2. The method of claim 1 , wherein the single correlation is a static correlator.3. The method of claim 1 , wherein pooling of feed-forward inputs is done by logical OR of consecutive feed-forward inputs.4. The method of claim 1 , wherein pooling of feed-forward inputs is done by concatenating consecutive inputs.5. The method of claim 1 , wherein a transformation operation is applied to each feed-forward input prior to pooling.6. The method of claim 5 , wherein the transformation operation is any of the following: a permutation operation claim 5 , a logical XOR operation claim 5 , or a logical AND operation.7. A computational method for the simulation of a hierarchical artificial neural network (ANN) claim 5 , the method comprising:(a) correlating two pooled feed-forward inputs, S(t), from time step, t, and S(t−1), from time-step, t−1 for all times t;(b) indirectly learning correlation between input S(t) and S(t−t′), where t′ is a positive integer that is ≥2; and(c) outputting correlations learned in (a) and (b).8. The method of claim 7 , wherein the output is a sparse distributed representation (SDR) matrix.9. The method of claim 7 , wherein the correlating step in (a) is done by a static correlator.10. The method of claim 7 , wherein pooling of feed-forward inputs is done by logical OR of consecutive feed-forward inputs.11. The method of claim 7 , wherein pooling of feed-forward inputs is done by ...

PROCESS FOR PREPARING A PARA-LINEAR ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOUND

Disclosed herein is a process for preparing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound. The process involves the steps of: (a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Clinear alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent; (b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an oxygen-containing source, thereby converting the first alkyl substituent which is a Cto Calkyl moiety to a hydroperoxide-containing substituted moiety to produce an isomeric mixture comprising a major amount of a para-linear alkyl-substituted, hydroperoxide-containing substituted aromatic compound; and (c) converting the hydroperoxide-containing substituted moiety to a hydroxyl moiety thereby providing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound. 1. A process for preparing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound , the process comprising the steps of:{'sub': 3', '8', '4+n', '8+n, '(a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Clinear alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent;'}{'sub': 3', '8, '(b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an oxygen- ...

PROCESS FOR PREPARING A PARA-BRANCHED ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOUND

Disclosed herein is a process for preparing an isomeric mixture comprising a major amount of a para-branched mono-alkyl-substituted hydroxyaromatic compound. The process involves the steps of: (a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Cbranched alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent; (b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an oxygen-containing source, thereby converting the first alkyl substituent which is a Cto Calkyl moiety to a hydroperoxide-containing substituted moiety to produce an isomeric mixture comprising a major amount of a para-branched alkyl-substituted, hydroperoxide-containing substituted aromatic compound; and (c) converting the hydroperoxide-containing substituted moiety to a hydroxyl moiety thereby providing an isomeric mixture comprising a major amount of a para-branched mono-alkyl-substituted hydroxyaromatic compound. 1. A process for preparing an isomeric mixture comprising a major amount of a para-branched mono-alkyl-substituted hydroxyaromatic compound , the process comprising the steps of:{'sub': 3', '8', '4+n', '8+n, '(a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Cbranched alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent;'}{'sub': 3', '8, '(b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an ...

PLUG FOR AN UNDERSEA CABLE

A plug for joining a polyethylene (PE) jacketed cable to a PE tube is provided. The plug includes first and second heating wires and a PE body. The PE body includes a first section and a second section. The first section is insertible into the PE tube and includes a first surface to engage with the PE tube. The first heating wires are embeddable in the first surface. The second section is within the first section and the PE jacketed cable is insertible into the second section. The second section includes a second surface to engage with the PE jacketed cable. The second heating wires are embeddable in the second section. 1. A plug for joining a polyethylene (PE) jacketed cable to a PE tube , the plug comprising:first and second heating wires; and a first section insertible into the PE tube and comprising a first surface to engage with the PE tube and in which the first heating wires are embeddable; and', 'a second section within the first section and into which the PE jacketed cable is insertible, the second section comprising a second surface to engage with the PE jacketed cable and in which the second heating wires are embeddable., 'a PE body comprising2. The plug according to claim 1 , wherein the first and second sections are annular and co-axial and the second section is thicker than the first section.3. The plug according to claim 1 , wherein the first surface is annular and faces radially outwardly and the second surface is annular and faces radially inwardly.4. The plug according to claim 1 , wherein the first heating wires are embeddable in an outermost surface of the first surface and the second heating wires are embeddable in an innermost surface of the second surface.5. The plug according to claim 1 , wherein the PE tube is formed to define a first bore receptive of the PE body and the second section is formed to define a second bore receptive of the PE jacketed cable.6. The plug according to claim 1 , further comprising additional heating wires claim 1 , ...

SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEM

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient. 1. A chiller comprising: i) a first compressor that pumps refrigerant through the first refrigerant circuit;', 'ii) a first tube-in-tube heat exchanger in fluid communication with the first compressor, wherein the first tube-in-tube heat exchanger comprises an inner lumen and an outer lumen that surrounds the inner lumen, wherein the refrigerant flows through the outer lumen;, 'a) a first refrigerant circuit, comprising i) a second compressor that pumps cryogenic refrigerant through the cryogenic refrigerant circuit;', 'ii) the first tube-in-tube heat exchanger in fluid communication with the second compressor; wherein the cryogenic refrigerant flows through the inner lumen;', 'iii) a second tube-in-tube heat exchanger in fluid communication with the first tube-in-tube heat exchanger; wherein the second tube-in-tube heat exchanger comprises an inner lumen and an outer lumen that surrounds the inner lumen, wherein the cryogenic refrigerant flows through ...

SYSTEMS AND METHODS FOR PREDICTING SERVICE DEMAND BASED ON GEOGRAPHICALLY ASSOCIATED EVENTS

Techniques for predicting an impact of one or more events on service demand are disclosed. Some embodiments include first and second sets of data characterising properties of historic events using metadata tags, and demand for services that are then filtered to distinguish ordinary demand from extra-ordinary demand. Machine learning is used to determine correlations between metadata tags and extra-ordinary demand to produce a third data set operable for predictive determinations of future event on service demand. 1. (canceled)2. A method of predicting event an impact of one or more events on service demand , comprising:a. receiving a first set of data comprising properties of one or more historic events, each having at least a temporal factor;b. characterising one or more properties of each of the one or more historic events into a plurality of metadata tags;c. receiving a second set of data relating to a demand for one or more services, the demand for each of the one or more services having at least a temporal factor;d. filtering the demand for the one or more services to thereby distinguish ordinary demand from extra-ordinary demand;e. determining, by machine learning, one or more correlations between two or more of the plurality of metadata tags, or combinations thereof and extra-ordinary demand, then quantifying the impact of the correlation with at least a binary characterisation;producing a third data set comprising a grouping of two or more of the metadata tags, or combinations thereof, associated with events having impact quantified above a threshold, wherein the third dataset is operable for predictive determinations of future event impact on service demand; andg. determining, by machine learning, a prediction model relating two or more of the metadata tags, or combinations thereof of the third data set to extraordinary demand.3. The method of claim 1 , wherein the method further comprising predicting a measure of impact a future event will have on the ...

Methods and apparatus for true high dynamic range (thdr) time-delay-and-integrate (tdi) imaging

In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic range of the resulting image. Fortunately, TDI imaging can be implemented with a digital focal plane array (DFPA) that includes a detector, analog-to-digital converter (ADC), and counter in each pixel and transfer circuitry connected adjacent pixels. During each integration period in the TDI scan, each detector in the DFPA generates a photocurrent that the corresponding ADC turns into digital pulses, which the corresponding counter counts. Between integration periods, the DFPA transfers the counts from one column to the next, just like in a TDI CCD. The DFPA also non-destructively transfers some or all of the counts to a separate memory. A processor uses these counts to estimate photon flux and correct any rollovers caused by “saturation” of the counters.

Unmanned Underwater Vehicle

An unmanned underwater vehicle (UUV) is disclosed. The UUV includes a body and a propulsion system for propelling and orienting the UUV. The propulsion system has an inlet formed in the body that facilitates fluid being drawn into the UUV from outside the body. The propulsion system also has a duct in fluid communication with the inlet. The duct is adapted to direct the fluid along a flow path. The propulsion system further includes a pump operable with the duct to increase the velocity of the fluid. In addition, the propulsion system includes a nozzle in fluid communication with the duct to receive the fluid at the increased velocity. The nozzle is supported about a side of the body and adapted to moveably redirect fluid out of the UUV. The propulsion system provides multi-axis control of the UUV.

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE IMAGING

When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital focal plane array (DFPA) with one or more m-bit counters can produce an image whose dynamic range is greater than the native dynamic range. In one example, the DFPA acquires a first image over a relatively brief integration period at a relatively low gain setting. The DFPA then acquires a second image over longer integration period and/or a higher gain setting. During this second integration period, counters may roll over, possibly several times, to capture a residue modulus 2of the number of counts (as opposed to the actual number of counts). A processor in or coupled to the DFPA generates a high-dynamic range image based on the first image and the residues modulus 2. 1. A method of generating a digital representation of a scene with a detector element operably coupled to an m-bit counter , the method comprising:generating, in the m-bit counter, a first count representative of detections by the detector element during a first integration period;generating, in the m-bit counter, a second count representative of detections by the detector element during a second integration period; andconcatenating k bits of the first count with at least l bits of the second count to form a third count,wherein m, k, and l are positive integers, k≦m, l≦m, and l−k≧m−1.22. The method of claim 1 , wherein generating the second count comprises counting more than 1 detections by the detector during the second integration period.3. The method of claim 2 , wherein concatenating the k bits of the first count with the at least l bits of the second count comprises appending the at least l bits of the second count to the k most significant bits of the first count.4. The method of claim 3 , wherein k Подробнее

ON-CHIP SENSOR FOR MONITORING ACTIVE CIRCUITS ON INTEGRATED CIRCUIT (IC) CHIPS

A sensor for on-chip monitoring the effects of operating conditions on a circuit, Integrated Circuit (IC) chips including the sensors, and a method of monitoring operating condition effects on-chip circuits, e.g., for the occurrence of electromigration. The sensor includes a multi-fingered driver associated with a monitored circuit, sensitive to known circuit parameter sensitivities. Sense and control logic circuit selectively driving the multi-fingered driver, and selectively monitoring for an expected multi-fingered driver response. 1. A sensor for monitoring for the effects of operating conditions , said sensor comprising:a multi-fingered driver associated with a monitored circuit on an integrated circuit (IC) chip, said monitored circuit having known parameter sensitivities, said multi-fingered driver being sensitive to one or more of said known parameter sensitivities;a load driven by said multi-fingered driver; andsense and control logic circuit providing a drive signal selectively driving said multi-fingered driver, and selectively monitoring said load for an expected multi-fingered driver response.2. A sensor as in claim 1 , wherein said IC chip is a CMOS IC chip and said multi-fingered driver is a CMOS driver including at least two field effect transistors (FETs) comprising a p-type FET (PFET) and an n-type FET (NFET).3. A sensor as in claim 2 , wherein said CMOS driver is a multi-fingered inverter claim 2 , said NFET is a fingered NFET and said PFET is a fingered NFET claim 2 , the gate of said fingered NFET and the gate of said fingered PFET being selectively driven from said sense and control logic circuit.4. A sensor as in claim 3 , wherein said the gate of said fingered NFET and the gate of said fingered PFET are selectively independently driven from said sense and control logic circuit.5. A sensor as in claim 2 , wherein said sense and control logic circuit comprises:control logic receiving select signals and providing said drive signal responsive to ...

Coupling Components to One Another Utilizing Electromagnetic Energy

A method of coupling components utilizing electromagnetic energy is disclosed. The method can include obtaining a first component having a first coupling portion, and obtaining a second component having a second coupling portion configured to interface with the first coupling portion. The method can also include disposing a hot melt adhesive on at least one of the first and second coupling portions, and disposing a susceptor proximate the hot melt adhesive. The method can further include mating the first and second coupling portions. In addition, the method can include applying electromagnetic energy to the susceptor. The susceptor can convert the electromagnetic energy to heat, which melts the hot melt adhesive into contact with the first and second coupling portions to couple the first and second components to one another upon solidification of the hot melt adhesive. 1. A method of coupling components utilizing electromagnetic energy , comprising:obtaining a first component having a first coupling portion;obtaining a second component having a second coupling portion configured to interface with the first coupling portion;disposing a hot melt adhesive on at least one of the first and second coupling portions;disposing a susceptor proximate the hot melt adhesive;mating the first and second coupling portions; andapplying electromagnetic energy to the susceptor, wherein the susceptor converts the electromagnetic energy to heat, which melts the hot melt adhesive into contact with the first and second coupling portions to couple the first and second components to one another upon solidification of the hot melt adhesive.2. The method of claim 1 , wherein the first coupling portion comprises an opening and the second coupling portion comprises a protrusion.3. The method of claim 2 , wherein the opening and the protrusion are tapered to generate axial compression between the first and second coupling portions.4. The method of claim 3 , wherein the opening and the ...

Composite Structural Component

A composite structural component is disclosed. The composite structural component can include a lattice structure, a casing disposed about at least a portion of the lattice structure, and a skin adhered to a surface of the casing. The lattice structure and the casing can be formed of a polymeric material and the skin can be formed of a metallic material. 1. A composite structural component , comprising:a lattice structure;a casing disposed about at least a portion of the lattice structure, wherein the lattice structure conforms to the casing; anda skin adhered to a surface of the casing,wherein the lattice structure and the casing are formed of a polymeric material and the skin is formed of a metallic material.2. The composite structural component of claim 1 , wherein the lattice structure and the casing are integrally formed with one another.3. The composite structural component of claim 1 , wherein the skin comprises a plating on the surface of the casing.4. The composite structural component of claim 1 , wherein the metallic material comprises nickel.5. The composite structural component of claim 1 , wherein the casing defines at least one of an exterior and an interior of the composite structural component.6. The composite structural component of claim 1 , wherein the casing comprises a cylindrical configuration.7. The composite structural component of claim 1 , further comprising a second casing disposed about at least a portion of the lattice structure opposite the first casing.8. The composite structural component of claim 7 , wherein a portion of the skin is adhered to a surface of the second casing.9. The composite structural component of claim 7 , wherein the second casing defines at least one of an exterior and an interior of the composite structural component.10. The composite structural component of claim 1 , wherein a portion of the skin is adhered to a surface of the lattice structure.11. A composite structural assembly claim 1 , comprising: a lattice ...

COMPOSITE GYPSUM BOARD FORMED FROM HIGH-SALT STUCCO AND RELATED METHODS

Disclosed are a composite gypsum board and a method of preparing gypsum board. The board contains at least one set gypsum layer sandwiched between face and back cover sheets. The set gypsum layer is formed from at least stucco and water. The stucco material generally includes a high salt impurity content, for example, when the stucco is calcined from certain sources of low-quality synthetic gypsum. For example, in some embodiments, the salts are chloride salts, e.g., sodium chloride (NaCl), potassium chloride (KCl), magnesium chloride (MgCl), and/or calcium chloride (CaCl). The board and methods improve the bond between the gypsum layer(s) and at least one of the cover sheets (e.g., the back cover sheet). Also provided are methods and systems relating to drying gypsum board. 1. A gypsum board comprising a set gypsum core disposed between a face cover sheet and a back cover sheet , the set gypsum core formed from a slurry comprising water , stucco , and a high salt impurity content , the board comprising at least two of the following:(a) perforations in the back cover sheet;(b) the back cover sheet containing high absorption paper;(c) starch included between the set gypsum core and at least one of the cover sheets; and(d) (i) a back skim coat layer defining first and second skim coat faces, the back skim coat layer formed from a second slurry comprising water, stucco, and a skim coat starch, the first face of the back skim coat facing the back cover sheet and the second face of the back skim coat facing the first core face, and (ii) a face skim coat layer defining first and second faces, the face skim coat layer formed from a third slurry comprising water, stucco, and optionally, the skim coat starch, the first face of the face skim coat layer facing a second face of the board core, and the second face of the face skim coat layer facing the face cover sheet, wherein the skim coat starch enhances the bond between the core and at least the back cover sheet, wherein the ...

User interfaces for continuous glucose monitoring

The subject matter disclosed herein provides methods for presenting glucose level data. Glucose data for a patient may be received. A current glucose level and a rate of change of the current glucose level may be determined based on the received glucose data. A first interface may be displayed on a screen of a device. The first interface may include a unitary icon. The unitary icon may display the current glucose level and a visualization of the rate of change. Related apparatus, systems, techniques, and articles are also described.

PLASTIC CONTAINER

Non-cylindrical plastic paint container with handle. 1. A plastic container , said container comprising a bucket and a lid sized to fit the bucket , said bucket comprising a rim at a mouth of the bucket , sidewalls , corners , and a bottom , said rim being integral at the top of each sidewall , each said sidewall having a width and comprising two borders integral on each of the borders to one of the corners and each sidewall also integral to the bottom , each said sidewall also comprising an upper portion , a nesting ridge and a lower portion , said upper portion comprising a first end near the mouth and a second end integral to the nesting ridge , and the lower portion comprising a first end integral to the nesting ridge and a second end integral to the bottom , each said lower portion of the sidewalls having a width greater near the nesting ridge than at the bottom , such that the mouth of the bucket is wider than the bottom and one of the buckets may be nested inside another bucket when the lids are removed and the buckets are empty.2. The container as in wherein the corners of the bucket claim 1 , the rim and the lid are rounded.3. The container as in wherein the sidewalls are four in number and the mouth of the bucket claim 1 , the rim and the lid are shaped as a rectangle.4. The container as in wherein the rectangle is a square5. The container as in wherein said lower portion of each of the sidewalls comprises an internal surface claim 1 , and at least one of the internal surfaces comprises ridges.6. The container as in wherein the ridges are disposed approximately parallel to the bottom of the bucket.7. The container as in wherein the rim comprises a breakaway tab at one or more of the corners.8. The container as in wherein the lid comprises an outer edge and a stacking ridge near the outer edge claim 1 , and the bucket further comprises a stacking loop integral to the bottom claim 1 , the sidewalls and the corners of the bucket claim 1 , said stacking loop ...

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE (THDR) TIME-DELAY-AND-INTEGRATE (TDI) IMAGING

In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic range of the resulting image. Fortunately, TDI imaging can be implemented with a digital focal plane array (DFPA) that includes a detector, analog-to-digital converter (ADC), and counter in each pixel and transfer circuitry connected adjacent pixels. During each integration period in the TDI scan, each detector in the DFPA generates a photocurrent that the corresponding ADC turns into digital pulses, which the corresponding counter counts. Between integration periods, the DFPA transfers the counts from one column to the next, just like in a TDI CCD. The DFPA also non-destructively transfers some or all of the counts to a separate memory. A processor uses these counts to estimate photon flux and correct any rollovers caused by “saturation” of the counters. 1. A method of estimating a total number of detections by a detector element in a detector array comprising at least N detector elements and a counter array comprising at least N m-bit counters , each detector element in the detector array operably coupled to a corresponding m-bit counter in the counter array , the method comprising:generating a time-delay-and-integrate (TDI) image with the detector array and the counter array over N integration periods;non-destructively reading a from an m-bit counter during at least one integration period in the N integration periods; and{'sup': 'th', 'estimating a total number of detections by an Ndetector element in the detector array during the N detection periods based at least in part on the TDI image and the count.'}2. The method of claim 1 , wherein non-destructively reading the count from the m-bit counter comprises:{'sup': 'th', 'non-destructively reading the at the end of the N−1integration period in the N integration periods.'}3. The method of claim 1 , wherein generating the TDI ...

APPROACHING HOMEOSTASIS IN A BINARY NEURAL NETWORK

Homeostasis-maintaining binary neural networks such as hierarchical temporal memories are provided. In various embodiments, a region of an artificial neural network is initialized. The region comprises a plurality of neurons and has a permanence value associated with each potential synaptic connection between neurons. The initialization comprises connecting a subset of the potential synaptic connections by synapses. A plurality of time-ordered inputs to the region is received. Some of the plurality of neurons are thereby caused to fire upon receipt of each time-ordered input. Upon receipt of each time-ordered input, for each potential synaptic connection between neurons, the permanence value is adjusted according to a firing sequence of the plurality of neurons. Those potential synaptic connections having a permanence value above a predetermined permanence threshold are connected when the total number of connected synapses in the region does not exceed a predetermined connectivity threshold. Synapses whose associated pre-synaptic neuron or post-synaptic neuron have more than a predetermined number of connected synapses are disconnected. 1. A method comprising: the region comprising a plurality of neurons and having a permanence value associated with each potential synaptic connection between neurons,', 'said initializing comprising connecting a subset of the potential synaptic connections to form synapses;, 'initializing a region of an artificial neural network,'} (i) adjusting the permanence value according to a firing sequence of the plurality of neurons;', '(ii) connecting those potential synaptic connections having a permanence value above a predetermined permanence threshold when the total number of connected synapses in the region does not exceed a predetermined connectivity threshold; and', '(iii) disconnecting synapses whose associated pre-synaptic neuron and/or post-synaptic neuron have more than a predetermined number of connected synapses., 'upon receipt ...

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE IMAGING

When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital focal plane array (DFPA) with one or more m-bit counters can produce an image whose dynamic range is greater than the native dynamic range. In one example, the DFPA acquires a first image over a relatively brief integration period at a relatively low gain setting. The DFPA then acquires a second image over longer integration period and/or a higher gain setting. During this second integration period, counters may roll over, possibly several times, to capture a residue modulus 2m of the number of counts (as opposed to the actual number of counts). A processor in or coupled to the DFPA generates a high-dynamic range image based on the first image and the residues modulus 2m. 1generating, in the m-bit counter, a first count representative of detections by the detector element during a first integration period;generating, in the m-bit counter, a second count representative of detections by the detector element during a second integration period; andconcatenating k bits of the first count with at least l bits of the second count to form a third count,wherein m, k, and l are positive integers, k≦m, l≦m, and l−k≧m−1.. A method of generating a digital representation of a scene with a detector element operably coupled to an m-bit counter, the method comprising: This application is a continuation of U.S. application Ser. No. 14/995,557, to be issued as U.S. Pat. No. 9,615,038, filed Jan. 14, 2016, which is a continuation of U.S. application Ser. No. 14/261,840, now U.S. Pat. No. 9,270,895, filed Apr. 25, 2014, which in turn claims priority, under 35 U.S.C. §119(e), from U.S. Provisional Application 61/860,438, filed Jul. 31, 2013, and entitled “True High Dynamic Range Imaging.” Each of these applications is hereby incorporated herein by reference in its entirety.This invention was made ...

Slurry distributor, system and method for using same

A slurry distribution system can include a feed conduit and a distribution conduit in fluid communication therewith. The feed conduit can include a first feed inlet and a second feed inlet disposed in spaced relationship thereto. The distribution conduit can extend generally along a longitudinal axis and include an entry portion and a distribution outlet in fluid communication therewith. The entry portion is in fluid communication with the first and second feed inlets of the feed conduit. The distribution outlet extends a predetermined distance along a transverse axis, which is substantially perpendicular to the longitudinal axis. The slurry distribution system can be placed in fluid communication with a gypsum slurry mixer adapted to agitate water and calcined gypsum to form an aqueous calcined gypsum slurry.

COMBINATION THERAPY WITH A HYALURONAN-DEGRADING ENZYME AND AN IMMUNE CHECKPOINT INHIBITOR

Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided. 1. A method for treating a cancer , comprising:administering a first composition comprising a soluble hyaluronidase, wherein the soluble hyaluronidase is conjugated to a polymer, or is formulated for slow release or is encoded in an oncolytic vector; andadministering a second composition comprising an immune checkpoint inhibitor, wherein:the hyaluronidase is administered simultaneously, sequentially or intermittently with the immune checkpoint inhibitor or in the same composition; andthe immune checkpoint inhibitor is an anti-CTLA4, anti-PD-1 or anti-PD-L1 antibody or antigen binding fragment thereof.2. The method of claim 1 , wherein the compositions are administered systemically.3. The method of claim 1 , wherein the compositions are administered intravenously.4. The method of claim 1 , wherein the soluble hyaluronidase is conjugated to a polymer.5. The method of claim 4 , wherein the polymer is a PEG moiety claim 4 , whereby the hyaluronidase is pegylated.6. The method of claim 1 , wherein the soluble hyaluronidase is administered at least or at least about or about or 5 minutes claim 1 , 15 minutes claim 1 , 30 minutes claim 1 , 1 hour claim 1 , 2 hours claim 1 , 3 hours claim 1 , 4 hours claim 1 , 6 hours claim 1 , 8 hours claim 1 , 12 hours claim 1 , 16 hours claim 1 , 18 hours claim 1 , 20 hours claim 1 , 22 hours claim 1 , 24 hours claim 1 , 30 hours claim 1 , 36 hours claim 1 , 40 hours or 48 hours prior to administration of the immune checkpoint inhibitor.7. The method of claim 1 , wherein the cancer comprises a solid tumor.8. The method of claim 7 , wherein:the tumor is determined to have moderate to high hyaluronan content or high hyaluronan content;moderate content is ...

Method for an Efficient Modeling of the Impact of Device-Level Self-Heating on Electromigration Limited Current Specifications

An efficient method of calculating maximum current limits for library gates in which a current limit includes the impact of self-heating effects associated with the maximum current. A maximum current solution is obtained in a self-consistent fashion, providing a way of determining the self-consistent solution in a rapid fashion without extensive numerical calculations or simulations. The present method provides a practical approach for characterizing a large library of gates for use in CMOS designs. 1. A method of designing and analyzing CMOS digital circuitry based on characterization a design cell library , the method comprising:a) determining electromigration-limited currents of said CMOS digital design cell library without including device-level self-heating effects;b) determining a thermal resistivity from data provided by each design cell of said CMOS library;c) computing a universal scaling curve of allowance reduction of said electromigration-limited currents as a function of said effects of device-level self-heating;d) determining by including a reduction from said self-heating effects said electromigration-limited currents of said CMOS design cell library; ande) obtaining a function of temperature increases from said thermal analysis based on said electromigration current limits.2. The method as recited in claim 1 , wherein said cell thermal resistivity is based on generic physical attributes that includes width claim 1 , height of said cells claim 1 , a number and size of device fingers.3. The method as recited in claim 1 , wherein said computing said universal curve based on said reduction caused by self-heating is a function of said temperature increase from said thermal analysis based on said electromigration current limit without considering any of said self-heating effects.4. The method as recited in claim 1 , wherein a self-consistent change in temperature caused by device self-heating scales other electrical characteristics of a CMOS gate that ...

METHODS AND APPARATUS FOR TRUE HIGH DYNAMIC RANGE (THDR) TIME-DELAY-AND-INTEGRATE (TDI) IMAGING

In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic range of the resulting image. Fortunately, TDI imaging can be implemented with a digital focal plane array (DFPA) that includes a detector, analog-to-digital converter (ADC), and counter in each pixel and transfer circuitry connected adjacent pixels. During each integration period in the TDI scan, each detector in the DFPA generates a photocurrent that the corresponding ADC turns into digital pulses, which the corresponding counter counts. Between integration periods, the DFPA transfers the counts from one column to the next, just like in a TDI CCD. The DFPA also non-destructively transfers some or all of the counts to a separate memory. A processor uses these counts to estimate photon flux and correct any rollovers caused by “saturation” of the counters. 1. A method of estimating a total number of detections by a detector element in a detector array comprising at least N detector elements and a counter array comprising at least Nm-bit counters , each detector element in the detector array operably coupled to a corresponding m-bit counter in the counter array , the method comprising:{'sup': 'm', 'generating, in a first m-bit counter in the counter array, a first count of less than or equal to 2−1, the first count representative of detections by a first detector element in the detector array during a first integration period in N integration periods;'} [{'sup': th', 'th', 'th, 'transferring the ncount from the nm-bit counter to the n+1m-bit counter;'}, {'sup': th', 'th', 'th', 'th', 'th, 'incrementing, by the n+1m-bit counter, the ncount to form an n+1count in response to detections by the n+1detector element during an n+1integration period in the N integration periods;'}], 'for n=1 to n=N−1{'sup': 'th', 'estimating a total number of detections by an Nth detector element in the ...

INTERLEAF PACKING AND DEPLOYMENT SYSTEM

A packing module includes a volumetrically efficient structure for separately retaining sensors and a cable of a sensor array. The packing module includes a tray that supports the sensors and a retaining leaf arrangement that extends outwardly from the tray to retain the cable on the tray. The retaining leaf arrangement includes a plurality of nested leaves that are spaced relative to each other. Packing the module includes placing the sensors separately and in succession on the tray and inserting a portion of the cable in the retaining leaf arrangement in between each placing of a sensor. The placement of a sensor and insertion of a portion of the cable occurs alternately until the entire sensor array is accommodated. Deployment of the sensor array may occur by alternately removing a sensor and a portion of the cable until the sensor array is displaced from the module.

TROCAR ASSEMBLY WITH A CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

The present disclosure relates to a trocar assembly with an integrated scope-cleaning structure. The trocar assembly may include a housing defining boundaries of a chamber with (a) a proximal opening configured to receive a distal end of a scope, and (b) a distal opening in fluid and mechanical communication with a trocar cannula. The trocar assembly may further include a cleaning element located at least partially between the proximal opening and the distal opening, where the cleaning element is movable with respect to the housing from at least a first setting where a first portion of the cleaning element may be in a first location and may form a first cleaning surface within the chamber, the first cleaning surface configured to remove debris from a distal end of the scope when the distal end of the scope contacts the first portion of the cleaning element. 1. A trocar assembly with an integrated scope-cleaning structure , the trocar assembly comprising:a housing defining boundaries of a chamber with (a) a proximal opening configured to receive a distal end of a scope, and (b) a distal opening in fluid and mechanical communication with a trocar cannula; anda cleaning element located at least partially between the proximal opening and the distal opening, where the cleaning element is movable with respect to the housing from at least a first setting to at least a second setting,wherein in the first setting, a first portion of the cleaning element is in a first location and provides a first cleaning surface within the chamber, the first cleaning surface configured to remove debris from a distal end of the scope when the distal end of the scope contacts the first portion of the cleaning element, andwherein in a second setting, the first portion of the cleaning element is displaced to a second location and the scope can extend longitudinally through the distal opening of the housing.2. The trocar assembly of claim 1 , wherein in the second setting claim 1 , an opening of ...

TROCAR ASSEMBLY WITH A CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

The present disclosure relates to a housing for a laparoscopic trocar assembly with an integrated scope-cleaning structure. The housing may include a shell forming a wall portion of a chamber and a cleaning element forming at least a portion of an internal surface of the chamber, the cleaning element configured to remove debris from a distal end of a scope upon contact between the cleaning element and the distal end of the scope. The cleaning element may be movable with respect to the shell of the housing in response to an input force upon the shell that moves a portion of the shell and a portion of the cleaning element between a default state and a displaced state. 1. A housing for a laparoscopic trocar assembly with an integrated scope-cleaning structure , the housing comprising:a shell forming a wall portion of a chamber; anda cleaning element forming at least a portion of an internal surface of the chamber, the cleaning element configured to remove debris from a distal end of a scope upon contact between the cleaning element and the distal end of the scope,wherein the cleaning element is movable with respect to the shell of the housing in response to an input force upon the shell that moves a portion of the shell and a portion of the cleaning element between a default state and a displaced state.2. The housing of claim 1 , further comprising an external surface at least partially formed by the shell claim 1 , wherein an external facing surface of the cleaning element forms at least a portion of the external surface of the housing.3. The housing of claim 1 , wherein the cleaning element is formed of a resilient material such that the cleaning element includes a tendency to assume the default state in the absence of an input force claim 1 , and wherein the default state forms an external shape that is generally continuous with the shell claim 1 , or that extends from the shell in a visually-contrasting manner.4. The housing of claim 1 , further comprising at least ...

TROCAR ASSEMBLY WITH A CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

The present disclosure relates to a trocar assembly with an integrated scope-cleaning structure. The trocar assembly may include a chamber with a proximal opening configured to receive a distal end of a scope. A cannula extend distally from the chamber and may be configured to extend distally into a patient body. The cannula may be further configured to receive the distal end of the scope such that the scope can be maneuvered through the cannula to a location within the patient body. The trocar assembly may include a cleaning element forming a surface within the chamber, where the surface of the cleaning element is configured to remove debris from at least one non-longitudinal, end-facing surface of the scope. 1. A trocar assembly with an integrated scope-cleaning structure , the trocar assembly comprising:a chamber with a proximal opening configured to receive a distal end of a scope;a cannula extending distally from the chamber, and configured to extend distally into a patient body, wherein the cannula is further configured to receive the distal end of the scope such that the scope can be maneuvered through the cannula to a location within the patient body; anda cleaning element forming a surface within the chamber, wherein the surface of the cleaning element is configured to remove debris from at least one non-longitudinal, end-facing surface of the scope.2. The trocar assembly of claim 1 , further comprising a valve configured to form a fluid barrier at or near the proximal opening between an environment within the chamber and an external environment.3. The trocar assembly of claim 1 , wherein cleaning element includes an opening aligned with a longitudinal axis of the cannula.4. The trocar assembly of claim 1 , wherein the surface of the cleaning element includes a curved portion.5. The trocar assembly of claim 1 , wherein the cleaning element is movable with respect to the chamber in response to an input force between a default state and a displaced state.6. ...

Intelligent user interface element selection using eye-gaze

Systems and methods disclosed herein are related to an intelligent UI element selection system using eye-gaze technology. In some example aspects, a UI element selection zone may be determined. The selection zone may be defined as an area surrounding a boundary of the UI element. Gaze input may be received and the gaze input may be compared with the selection zone to determine an intent of the user. The gaze input may comprise one or more gaze locations. Each gaze location may be assigned a value according to its proximity to the UI element and/or its relation to the UI element's selection zone. Each UI element may be assigned a threshold. If the aggregated value of gaze input is equal to or greater than the threshold for the UI element, then the UI element may be selected.

Method for Manufacturing Polymer-Metal Composite Structural Component

A composite structural component is disclosed. The composite structural component can include a lattice structure, a casing disposed about at least a portion of the lattice structure, and a skin adhered to a surface of the casing. The lattice structure and the casing can be formed of a polymeric material and the skin can be formed of a metallic material. A method of manufacturing a composite structural component is disclosed. The method can include creating a casing of a polymeric material and creating a lattice structure of a polymeric material disposed about at least a portion of the casing. The method can include sealing the porosity of the casing and lattice structure. The method can include adhering a skin of a metallic material to at least a portion of the casing. At least one of creating a lattice structure and creating a casing comprises utilizing an additive manufacturing process. 1. A composite structural component , comprising:a lattice structure;a casing disposed about at least a portion of the lattice structure, wherein the lattice structure conforms to the casing; anda skin adhered to a surface of the casing,wherein the lattice structure and the casing are formed of a polymeric material and the skin is formed of a metallic material.2. The composite structural component of claim 1 , wherein the lattice structure and the casing are integrally formed with one another.3. The composite structural component of claim 1 , wherein the skin comprises a plating on the surface of the casing.4. The composite structural component of claim 1 , wherein the metallic material comprises nickel.5. The composite structural component of claim 1 , wherein the casing defines at least one of an exterior and an interior of the composite structural component.6. The composite structural component of claim 1 , wherein the casing comprises a cylindrical configuration.7. The composite structural component of claim 1 , further comprising a second casing disposed about at least a ...

ELECTRON BEAM ADDITIVE MANUFACTURING

A method and apparatus particularly for additively manufacturing materials that are susceptible to hot cracking. The additive manufacturing process may include a leading energy beam () for liquefying a raw material to form a melt pool (), and a trailing energy beam () directed toward a trailing region of the melt pool. The trailing energy beam may be configured to enhance agitation and/or redistribution of liquid in the melt pool to prevent hot cracking, reduce porosity, or improve other characteristics of the solidified part. The method and apparatus also may improve processing parameters, such as adjusting vacuum level to prevent volatilization of alloying agents, or providing a chill plate to control interpass temperature. The process may be used to form new articles, and also may be used to enhance tailorability and flexibility in design or repair of pre-existing articles, among other considerations. 1. A method of additive manufacturing , comprising:providing a raw material in solid state form;exposing the raw material to a leading energy beam thereby liquefying the raw material;forming a melt pool with the liquefied raw material, the melt pool having a leading region and a trailing region; andexposing the trailing region of the melt pool to a trailing energy beam.2. The method of additive manufacturing according to claim 1 ,wherein the forming the melt pool with the liquefied raw material is performed as the leading energy beam moves in a travel direction along an x-y plane;wherein the leading region of the melt pool is proximal to the leading energy beam as the leading energy beam moves in the travel direction; andwherein the trailing region of the melt pool trails the leading region as the leading energy beam moves in the travel direction.3. The method of additive manufacturing according to claim 1 , further comprising:solidifying the melt pool to form a re-solidified layer that trails the trailing region as the trailing energy beam moves in the travel ...

COMBINATION THERAPY WITH AN ANTI-HYALURONAN AGENT AND THERAPEUTIC AGENT

Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers. 1. A method for treating a stromal barrier cancer , comprising administering to a subject:a) a composition comprising a soluble PH20 hyaluronidase conjugated to a polymer; andb) a composition comprising a tumor-targeted taxane that is nab-paclitaxel or nab-docetaxel, wherein:the composition comprising the soluble PH20 hyaluronidase conjugated to a polymer, and the composition comprising the tumor-targeted taxane are administered separately in two compositions or in a single composition.2. The method of claim 1 , wherein the compositions are administered sequentially.3. The method of claim 1 , wherein the cancer is pancreatic cancer.4. The method of claim 1 , further comprising administering a composition comprising a nucleoside analog.5. The method of claim 1 , wherein the cancer is selected from among pancreatic cancer claim 1 , ovarian cancer claim 1 , lung cancer claim 1 , colon cancer claim 1 , prostate cancer claim 1 , non-small-cell lung cancer (NSCLC) claim 1 , in situ carcinoma (ISC) claim 1 , squamous cell carcinoma (SCC) claim 1 , cervical cancer claim 1 , head and neck cancer and breast cancer.6. The method of claim 1 , wherein the soluble PH20 hyaluronidase comprises a sequence of amino acids that has at least 95% sequence identity to the sequence set forth in SEQ ID NO: 4.7. The method of claim 1 , wherein:the hyaluronidase is a truncated PH20; andthe truncated PH20 comprises a sequence of amino acids that contains amino acids 36-464 of SEQ ID NO:1, or comprises a sequence of amino acids that has at least 95% sequence identity to a sequence of amino acids that contains at least amino acids 36-464 of SEQ ID NO:1 and retains hyaluronidase ...

VIRTUALIZATION IN HIERARCHICAL CORTICAL EMULATION FRAMEWORKS

Embodiments of the present invention describe a hierarchical cortical emulation using a scratchpad memory device and a storage class memory device. The scratchpad memory device is partitioned into a first subset of memory locations and a second subset of memory locations. A processor from a neural network device is assigned a first memory portion from the first subset, a second memory portion from the second subset, and a third memory portion from the storage class memory device. Further the neural network device and a memory controller perform a compute cycle for a hierarchical level k, 1≤k≤n, n being total number of levels. A compute cycle includes performing, by the processor, computations from the level k using neuron data stored in the first memory portion, and in parallel, copying by the memory controller, the neuron data for a hierarchical level k+1 from the third memory portion to the second memory portion. 1. A hierarchical cortical emulation system comprising:a neural network device comprising a plurality of processors;a memory controller communicatively coupled with the neural network device;a scratchpad memory device communicatively coupled to the memory controller; anda storage class memory device communicatively coupled to the memory controller; the scratchpad memory device is partitioned into a first subset of memory locations and a second subset of memory locations;', 'a processor from the plurality of processors of the neural network device is assigned a first memory portion from the first subset of memory locations, a second memory portion from the second subset of memory locations, and a third memory portion from the storage class memory device; and', performing, by the processor, computations for a neuron from the level k using neuron data for the hierarchical level k stored in the first memory portion; and', 'in parallel, copying by the memory controller, the neuron data for a hierarchical level k+1 from the third memory portion to the second ...

SCOPE WITH INTEGRAL CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

A scope includes a housing having a distal portion with a distal end. A lens is at the distal end. A cleaning element is operatively coupled to the distal portion of the housing, wherein the cleaning element is movable between a first position and a second position contacting the distal end. 1. A scope , comprising:a housing having a distal portion with a distal end;a lens at the distal end; anda cleaning element operatively coupled to the distal portion of the housing, wherein the cleaning element is movable between a first position and a second position contacting the distal end.2. The scope of claim 1 , wherein the cleaning element is slidably coupled to a side wall of the housing at the distal portion claim 1 , and as the cleaning element is moved toward the first position claim 1 , the cleaning element is configured to move across the lens.3. The scope of claim 2 , wherein the cleaning element is made of a shape memory material.4. The scope of claim 1 , wherein the cleaning element further comprises:a cover rotatably coupled to the distal portion of the housing at the distal end, the cover extending over the lens; anda band extending laterally across the cover, wherein the band is configured to remain in contact with the cover as the cover revolves between the first position and the second position.5. The scope of claim 4 , wherein the band has a first end coupled to the distal portion at a first point and a second end opposite the first end coupled to the distal portion at a second point laterally opposing the first point.6. The scope of claim 1 , wherein the cleaning element comprises a band extending laterally across the lens claim 1 , the band having a first segment with a cleaning surface configured to contact the lens as the lens is rotatable with respect to the housing.7. The scope of claim 6 , wherein the band is movable from the second position to the first position to allow the lens to move distally with respect to the distal end of the housing.8. The ...

MODIFIED HYALURONIDASES AND USES IN TREATING HYALURONAN-ASSOCIATED DISEASES AND CONDITIONS

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions. 1. A method for identifying a subject , who has pancreatic cancer , for a treatment that includes administering a polymer-modified soluble hyaluronidase , comprising:a) obtaining a tumor biopsy sample from the subject, wherein the sample is a pancreatic tumor biopsy;b) measuring the level of expression of hyaluronan in the tumor biopsy sample; andc) identifying, for treatment, a subject with a tumor that is susceptible to a treatment that includes a polymer-modified soluble hyaluronidase, wherein hyaluronan is expressed in at least 30% of the tumoral area in the tumor biopsy sample from the subject, wherein the polymer-modified soluble hyaluronidase has longer serum half-life than the unmodified soluble hyaluronidase.2. The method of claim 1 , wherein the polymer-modified soluble hyaluronidase is PEGylated or sialated or modified with dextran or a polypeptide.3. The method of claim 1 , wherein the polymer-modified soluble hyaluronidase is PEGylated.4. The method of claim 1 , wherein hyaluronan is expressed in at least 50% of the tumoral area in the tumor biopsy sample.5. The method of claim 1 , wherein measurement is effected by immunohistochemistry.6. The method of claim 1 , wherein measurement is effected by immunofluorescence.7. The ...

TROCAR ASSEMBLY WITH A CLEANING ELEMENT FOR USE DURING A LAPAROSCOPIC PROCEDURE

A trocar assembly includes a cannula having a proximal portion and an opposing distal portion. The distal portion is configured to extend into a patient body. The cannula defines an access channel between the proximal portion and the distal portion, wherein the access channel is configured to receive a scope such that the scope can be maneuvered through the access channel to a location within the patient body. A cleaning element at the distal portion is configured to contact at least a distal end of the scope. 1. A trocar assembly , comprising:a proximal portion;a cannula extending between the proximal portion and a distal portion of the trocar assembly opposite the proximal portion, the distal portion configured to extend into a patient body, the cannula defining an access channel between a first opening at the proximal portion and a second opening at the distal portion, wherein the access channel is configured to receive a scope such that the scope can be maneuvered through the access channel to a location within the patient body; anda cleaning element at the distal portion, wherein the cleaning element is configured to contact at least a distal end of the scope with the cleaning element in a first position.2. The trocar assembly of claim 1 , wherein the cleaning element is movable between the first position and a second position claim 1 , and in the first position claim 1 , the cleaning element contacts at least the distal portion of the scope with the scope positioned in the access channel.3. The trocar assembly of claim 2 , wherein in the first position claim 2 , the cleaning element extends radially inward toward a longitudinal axis of the cannula.4. The trocar assembly of claim 2 , wherein in a second position claim 2 , the cleaning element extends distally outward from the second opening.5. The trocar assembly of claim 1 , further comprising an actuator at the proximal portion of the cannula claim 1 , the actuator operatively coupled to the cleaning element ...

Air cleaner assemblies and methods of use

Air cleaner assemblies, components therefor, and features thereof are described. Also described are methods of assembly and use. In depicted examples, the air cleaner assemblies and components optionally use advantageous housing seal features. Methods of assembly and use are described.

TROCAR ASSEMBLY WITH A MOVABLE CLEANING ELEMENT

A trocar assembly with an integrated scope-cleaning structure may have a proximal portion configured for accessibility by a user and a cannula extending distally from the proximal portion and configured to extend distally into a patient body, where the cannula is further configured to receive a distal end of a scope such that the scope can be maneuvered through the cannula to a location within the patient body. A cleaning element may be included, where the proximal portion includes a housing, where the cleaning element is substantially located within the housing.

METHODS AND APPARATUS FOR IN-PIXEL FILTERING IN FOCAL PLANE ARRAYS

Digital focal plane arrays (DFPAs) with multiple counters per unit cell can be used to convert analog signals to digital data and to filter the digital data. Exemplary DFPAs include two-dimensional arrays of unit cells, where each unit cell is coupled to a corresponding photodetector in a photodetector array. Each unit cell converts photocurrent from its photodetector to a digital pulse train that is coupled to multiple counters in the unit cell. Each counter in each unit cell can be independently controlled to filter the pulse train by counting up or down and/or by transferring data as desired. For example, a unit cell may perform in-phase/quadrature filtering of homodyne- or heterodyne-detected photocurrent with two counters: a first counter toggled between increment and decrement modes with an in-phase signal and a second counter toggled between increment and decrement modes with a quadrature signal. 1. An apparatus for counting pulses representing an analog signal , the apparatus comprising: (i) a converter to convert a photocurrent from at least one photodetector in the photodetector array to a series of pulses;', '(ii) a first counter, operably coupled to the converter, to count first pulses in the series of pulses in response to a first clock selection signal and according to a first operating mode; and', '(iii) a second counter, operably coupled to the converter, to count second pulses in the series of pulses in response to a second clock selection signal and according to a second operating mode,, 'an integrated circuit operably coupled to a photodetector array, the integrated circuit comprising a plurality of unit cells, wherein at least one unit cell in the plurality of unit cells compriseswherein the first operating mode and the second operating mode are independently controllable by a first control signal and a second control signal, respectively.2. The apparatus of claim 1 , wherein the at least one unit cell further comprises a switch claim 1 , wherein ...

MODIFIED HYALURONIDASES AND USES IN TREATING HYALURONAN-ASSOCIATED DISEASES AND CONDITIONS

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions. 1. A method for treating a tumor with a polymer-conjugated soluble human PH20 hyaluronidase in a subject having cancer , comprising:a) measuring the expression or level of hyaluronan in a tumor sample from the subject; and the tumor sample is a tumor biopsy sample;b) determining the level of expression of hyaluronan in the tumor biopsy sample;c) identifying, for treatment, the subject, wherein hyaluronan is expressed in at least 30% of the tumoral area in the tumor biopsy sample from the subject; and thend) administering to the subject, the polymer-conjugated soluble hyaluronidase.2. The method of claim 1 , wherein the polymer-conjugated soluble human PH20 is a PEGylated PH20 (PEGPH20).3. The method of claim 1 , wherein the cancer is selected from among ovarian cancer claim 1 , in situ carcinoma (ISC) claim 1 , squamous cell carcinoma (SCC) claim 1 , prostate cancer claim 1 , gastric cancer claim 1 , non-small cell lung cancer claim 1 , breast cancer claim 1 , brain cancer and colon cancer.4. The method of claim 1 , further comprising administering a second agent that is an anti-cancer agent or treatment for treating the tumor in the subject.5. The method of claim 1 , wherein the polymer-conjugated soluble hyaluronidase is a C-terminally ...

Turbine Engine Airfoil and Platform Assembly

A turbine airfoil ( 22 A) is formed by a first process using a first material. A platform ( 30 A) is formed by a second process using a second material that may be different from the first material. The platform ( 30 A) is assembled around a shank ( 23 A) of the airfoil. One or more pins ( 36 A) extend from the platform into holes ( 28 ) in the shank ( 23 A). The platform may be formed in two portions ( 32 A, 34 A) and placed around the shank, enclosing it. The two platform portions may be bonded to each other. Alternately, the platform ( 30 B) may be cast around the shank ( 23 B) using a metal alloy with better castability than that of the blade and shank, which may be specialized for thermal tolerance. The pins ( 36 A- 36 D) or holes for them do not extend to an outer surface ( 31 ) of the platform, avoiding stress concentrations.

Modular turbine airfoil and platform assembly with independent root teeth

A turbine airfoil ( 22 E-H) extends from a shank ( 23 E-H). A platform ( 30 E-H) brackets or surrounds a first portion of the shank ( 23 E-H). Opposed teeth ( 33, 35 ) extend laterally from the platform ( 30 E-H) to engage respective slots ( 50 ) in a disk. Opposed teeth ( 25, 27 ) extend laterally from a second portion of the shank ( 29 ) that extends below the platform ( 30 E-H) to engage other slots ( 52 ) in the disk. Thus the platform ( 30 E-H) and the shank ( 23 E-H) independently support their own centrifugal loads via their respective teeth. The platform may be formed in two portions ( 32 E-H, 34 E-H), that are bonded to each other at matching end-walls ( 37 ) and/or via pins ( 36 G) passing through the shank ( 23 E-H). Coolant channels ( 41, 43 ) may pass through the shank beside the pins ( 36 G).

COMBINATION THERAPY WITH A HYALURONAN-DEGRADING ENZYME AND AN IMMUNE CHECKPOINT INHIBITOR

Provided are methods of treatment of cancers with combinations of and compositions containing a soluble hyaluronidase, such as a polymer-modified soluble hyaluronidase, and an immune checkpoint inhibitor for treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided. 1. A method for treating a cancer , comprising:intravenously administering a first composition comprising a soluble hyaluronidase, wherein the hyaluronidase is conjugated to a polymer or is formulated for slow release or is encoded in a viral vector; andthen, within 8 to 48 hours after administering the hyaluronidase, intravenously administering a second composition comprising an immune checkpoint inhibitor.2. The method of claim 1 , wherein the hyaluronidase is conjugated to a polymer.3. The method of claim 1 , wherein:the cancer comprises a tumor that expresses hyaluronan; andthe hyaluronidase is conjugated to a polymer.4. The method of claim 1 , wherein the hyaluronidase is administered separately from claim 1 , and at least 12 hours up to 48 hours before the immune checkpoint inhibitor; wherein the immune checkpoint inhibitor is an immune checkpoint inhibitor antibody or an antigen binding fragment thereof.5. The method of claim 1 , wherein the immune checkpoint inhibitor is an immune checkpoint inhibitor antibody or antigen binding fragment thereof that is an anti-CTLA-4 claim 1 , anti-PD-1 claim 1 , or anti-PD-L1 antibody claim 1 , or comprises an antigen binding fragment of the anti-CTLA-4 claim 1 , anti-PD-1 claim 1 , or anti-PD-L1 antibody.6. The method of claim 2 , wherein the polymer-conjugated soluble hyaluronidase is a PEGylated soluble PH20 hyaluronidase.7. The method of claim 2 , wherein the hyaluronidase is a human hyaluronidase.8. The method of claim 1 , wherein the cancer comprises a solid tumor.9. The method of claim 1 , wherein the cancer is selected from among pancreatic cancer claim 1 , breast cancer claim 1 , prostate cancer claim 1 ...

OLEFIN SULFONATES

The present disclosure is directed to surfactants (in particular olefin sulfonates), surfactant packages, compositions derived thereof, and uses thereof in hydrocarbon recovery. Methods of making olefin sulfonate surfactants are also described. 1. A surfactant composition comprising water , an olefin sulfonate , and one or more additional components chosen from one or more co-surfactants , a viscosity-modifying polymer , or any combination thereof , wherein the olefin sulfonate is a propylene oligomer comprising one or more sulfonate groups , and wherein the propylene oligomer has an average total branching of about 3 to about 15 per molecule.2. The composition of claim 1 , wherein the one or more co-surfactants comprise an anionic surfactant.3. The composition of claim 2 , wherein the anionic surfactant comprises a sulfonate claim 2 , a disulfonate claim 2 , a sulfate claim 2 , a disulfate claim 2 , a sulfosuccinate claim 2 , a disulfosuccinate claim 2 , a carboxylate claim 2 , a dicarboxylate claim 2 , or any combination thereof.4. The composition of claim 2 , wherein the anionic surfactant comprises one of the following:a branched or unbranched C6-C32:PO (0-65):EO (0-100)-carboxylate;a C8-C30 alkyl benzene sulfonate (ABS);a sulfosuccinate surfactant; {'br': None, 'R1—R2—R3'}, 'a surfactant defined by the formula below'}whereinR1 comprises a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having 6-32 carbon atoms and an oxygen atom linking R1 and R2;R2 comprises an alkoxylated chain comprising at least one oxide group selected from the group consisting of ethylene oxide, propylene oxide, butylene oxide, and any combination thereof; andR3 comprises a branched or unbranched hydrocarbon chain comprising 2-12 carbon atoms and from 2 to 5 carboxylate groups; ora surfactant defined by the formula belowwhereinR4 is, individually for each occurrence, a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, ...

Implantable limb lengthening nail driven by a shape memory alloy

An implantable intramedullary bone lengthening device for correction of limb length deficiencies without a need for transcutaneous connections. The implantable intramedullary bone lengthening nail has an implantable housing, an adjustment mechanism attached to the telescoping cylinder housing, and a drive assembly attached to the housing and the adjustment mechanism for transmitting an expansion force to the adjustment mechanism. The implantable housing may be sealed, encapsulating the unit. The intramedullary bone lengthening nail is inserted into the intramedullary cavity of a bone, which may have been enlarged by reaming. The implantable housing of the intramedullary nail is formed from two telescoping cylinders and is affixed at either end to the bone using pins. The adjustment mechanism is attached to both cylinders of the housing and includes a mechanism for expanding the nail and a ratcheting mechanism for regulating the expansion. The drive assembly includes a shape memory alloy to provide an expansion force. The drive mechanism transmits the expansion force in response to an external signal to the adjustment mechanism.

System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient

A system controls and manages administration of a therapeutic gas, such as NO, O 2 , or the like, to a spontaneously breathing, non-ventilated patient such that concentrated NO is as low as reasonably possible while delivering the desired amount of NO to the distal portions of the lungs. The system includes an entrainment cell that provides remote, turbulent mixing with low temporal latency and can be used with a nasal cannula or a mask. The entrainment cell uses room air to dilute the therapeutic gas; however, supplementary gases can also be used. A baffle can be included to promote mixing and a flow sensor can also be used if desired. Multiple ports can be included in the entrainment cell. An equalizing valve is also disclosed.

Method for the preparation of metallocene catalysts

Process of preparing silica-supported catalysts. A support material comprising silica particles impregnated with an alumoxane co-catalyst with at least one-half of the co-catalyst disposed within the internal pore volume of the silica is contacted with a dispersion of a metallocene catalyst in an aromatic solvent. The dispersion and support are mixed at a temperature of about 10° C. or less to enable the metallocene to become reactively supported on and impregnated within the alumoxane-impregnated silica particles. The supported catalyst is recovered from the aromatic solvent and washed with an aromatic hydrocarbon and then a paraffinic hydrocarbon at a temperature of about 10° C. or less. The washed catalyst is dispersed in a viscous mineral oil.

Filter cartridges; air cleaner assemblies; housings; features; components; and, methods

According to the present disclosure, air cleaner assemblies, components, features, and methods relating thereto, are described. These features, in part, relate to configuration of a preferred seal arrangement and seal surface of the cartridge. Particular arrangements are shown, in which: the filter cartridge includes a seal arrangement having a axial pinch seal surface with a projection/recess contour including at least one projection thereon; and, the cartridge includes a seal contour projection stabilizing portion at a location in perimeter alignment with the portion of the seal pinch arrangement including the first housing engagement projection. Additional features are included that relate to clean air separator section tubes of a precleaner arrangement secured to a cartridge. These features can be used in cartridges including features outlined above, or in alternative cartridges. Additional features of air cleaner arrangements and filter cartridges in accord with the above are described.

Nestable containers with reversibly deformable closures

Embodiments include nestable containers and reversibly deformable closures for the containers that are disposable in the nested arrangement. For example, materials and methods are described for making and using a food storage apparatus having food storage containers and closures for the containers, the food storage apparatus including a plurality of nested food storage containers each having an opening, and a plurality of reversibly deformable closures for covering the openings, with the containers being nestable with each other with one of the closures disposed between each nested container.

Interosmolar fluid removal

There are many medical situations that require removal of fluid from a patient. There are many ways to remove the fluid but many of these situations have not been solved. Herein, inventions are disclosed that generate osmotic pressure that can be used to remove these fluids very effectively, a technique which requires no harsh suction or pumping. One embodiment involves implanting a reservoir that has a semipermeable membrane sidewall. The reservoir contains trapped osmotic solutes that can not pass out through the membrane. But fluid from the patient can flow in. The osmotic pressure from the trapped solutes in the reservoir draws fluid from the patient across the semipermeable membrane and into the device. In some versions, the membrane can be changed as desired during the lifetime of the device by pulling the membrane out through the implanted device and putting a new one back in.

Catalytic thermal barrier coatings

A catalyst element ( 30 ) for high temperature applications such as a gas turbine engine. The catalyst element includes a metal substrate such as a tube ( 32 ) having a layer of ceramic thermal barrier coating material ( 34 ) disposed on the substrate for thermally insulating the metal substrate from a high temperature fuel/air mixture. The ceramic thermal barrier coating material is formed of a crystal structure populated with base elements but with selected sites of the crystal structure being populated by substitute ions selected to allow the ceramic thermal barrier coating material to catalytically react the fuel-air mixture at a higher rate than would the base compound without the ionic substitutions. Precious metal crystallites may be disposed within the crystal structure to allow the ceramic thermal barrier coating material to catalytically react the fuel-air mixture at a lower light-off temperature than would the ceramic thermal barrier coating material without the precious metal crystallites.

Single cam operated attachment device

A fastening device (F) with first ( 16 ) and second sides ( 30 ) attaches a first device ( 10 ) to a mounting rail ( 12 ) of a second device ( 14 ). A top section ( 44 ) for mounting the first device extends from the first or second sides. The sides are adapted to removably clamp about the rail. A clamping member ( 46 ) extends between the first and second sides. An extended end ( 48 ) of the clamping member extends through the first side, and an opposing end ( 50 ) is coupled with the second side. The clamping member extended portion ( 48 ) is movably coupled to a single cam member ( 56 ) operably mounted with the first side for drawing the sides closer together into a clamping position ( 58 ) to mate the sides with the rail.

Production of low fine sediment high TBN phenate stearate

An overbased phenate stearate is produced by overbasing a mixture that comprises sulfurized phenate, metal stearate (such as calcium stearate), at least one solvent, calcium hydroxide, and water, by contacting the mixture with carbon dioxide in the presence of an alkyl polyhydric alcohol, such as ethylene glycol. The level of agitation is maintained at a level sufficiently high so that all solids are suspended over the length of the overbasing step. The polyhydric alcohol to water ratio is maintained sufficiently high so that the ratio is at least 4:1 at the end of the overbasing step. The overbased mixture is stripped to produce an overbased phenate stearate having less than 0.10 vol.% fine sediments.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Determining a user's urgency index associated with a physiological condition

Display screen or portion thereof with graphical user interface for analyte data presentation

Display screen or portion thereof with graphical user interface for presentation of analyte data

Glycemic urgency assessment and alerts interface

Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user - entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump.

Glycemic urgency assessment and alerts interface

Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user - entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump.

Glycemic urgency assessment and alerts interface

Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user - entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump.

Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor

Provided are combinations of a hyaluronan-degrading enzyme, such as a hyaluronidase, and an immune checkpoint inhibitor. The combinations are used to improve any therapy, particularly anti-tumor therapy, that includes administration of immune checkpoint inhibitors or other inhibitors of the immunosuppressive effects of tumors. The combination therapy is for use in treating cancers, including solid and non-solid tumors. Methods of treating cancers also are provided.

Filter element, air cleaner assembly, and methods

An air cleaner assembly includes a housing and a removable cover. A filter element is removably positioned in the housing. A two-part mating catch assembly includes a first part that is secured to the cover and a second part that is on one of the housing and the filter element. The first part and second part are positioned to releasably mate when the filter element is operably mounted within the housing.

Air cleaner assemblies and cartridge

Air cleaner assemblies, components therefor, and features thereof are described. Also described are methods of assembly and use. In depicted examples, the air cleaner assemblies and components optionally use advantageous housing seal features. Methods of assembly and use are described.

Filter element, air cleaner assembly, and methods

An air cleaner assembly includes a housing and a removable cover. A filter element is removably positioned in the housing. A two-part mating catch assembly includes a first part that is secured to the cover and a second part that is on one of the housing and the filter element. The first part and second part are positioned to releasable, mate when the filter element is operably mounted within the housing

Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane

Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions.

Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Provided herein are diagnostic methods for identifying subjects susceptible to treatment with a hypoxia-activated agent, and related methods. Also provided herein are methods of monitoring treatments with anti-hyaluronan agents, and related methods.

Modified hyaluronidases for use in treating hyaluronan-associated diseases and conditions

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions.

Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions.

Combination therapy with an anti-hyaluronan agent and therapeutic agent

Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

Combination therapy with an anti-hyaluronan agent and therapeutic agent

Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor

Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.