Exhaust gas turbine of a turbocharger for an internal combustion engine

An exhaust gas turbine portion of a vehicle engine turbocharger is provided with at least one variable guide-blade cascade with guide blades in a nozzle opening to the turbocharger rotor for effectively changing the cross section of the exhaust flow to the rotor wherein the angle of the guide blades is selectively settable by an adjusting device. The width dimension of the gap between the ends of the guide-blade cascade and the casing wall defining the nozzle is adjustable between a substantially zero gap dimension and a maximum gap dimension.

Exhaust gas turbocharger turbine

An exhaust-gas turbocharger turbine of an internal combustion engine is provided with a spiral guide passage arranged in a turbine housing, a turbine impeller, a flow gap be ween the guide passage and the turbine impeller, and guide blades forming a guide cascade. The guide cascade with the guide blades projects axially from a support, arranged so as to be displaceable in the axial direction in the turbine housing, in such a way that the guide blades, in normal operation, are mounted in recesses of a housing wall part of the turbine housing, the recesses, in the form of a female piece, forming a mating profile shape for the guide blades. In braking operation of the internal combustion engine, the guide blades project into the flow gap during an axial displacement of the support. The device with actuation for the braking operation can be fitted as a complete module into the turbine spiral.

Antibody preparation

The present invention relates to the field of biotechnology, and in particular to the field of antibodies. Provided herein are novel methods for removing glycosylated antibody variants from an antibody preparation, an antibody preparation obtained by said method, and a pharmaceutical composition comprising the same.

Antibody Preparation

The present invention relates to the field of biotechnology, and in particular to the field of antibodies. Provided herein are novel methods for removing glycosylated antibody variants from an antibody preparation, an antibody preparation obtained by said method, and a pharmaceutical composition comprising the same. 1. A method for reducing the amount of a CDR-H1 glycosylated antibody variant that competes for binding to human VEGF-A with the antibody bevacizumab in a preparation comprising said antibody variant , the method comprising the following steps: (i) subjecting said preparation to cation exchange chromatography (CEX) , size exclusion chromatography (SEC) or lectin affinity purification (LAP) , (ii) analyzing fractions obtained in step (i) for the presence of said CDR-H1 glycosylated antibody variant by HPLC-MS(/MS); and (iii) removing fractions comprising said CDR-H1 glycosylated antibody variant.2. The method of claim 1 , further comprising changing a purification process for bevacizumab claim 1 , by adjusting splitting criteria for a CEX-step and/or introducing an SEC purification step.3. The method of claim 1 , wherein said competition is measured by ELISA claim 1 , flow cytometry or surface plasmon resonance (SPR) assay.4. The method of claim 1 , wherein said antibody comprises a CDR-H1 having the amino acid sequence shown in SEQ ID NO: 1 (SGYTFTNYGMN) claim 1 , wherein the first N is glycosylated.5. The method of claim 1 , wherein said N-glycosylation is a complex type glycosylation.6. The method of claim 1 , wherein said CDR-H1 glycosylated variant (i) has a reduced binding affinity to VEGF in comparison to a non-CDR-H1 glycosylated variant and/or (ii) shows a reduced inhibition on the VEGF-dependent proliferation of HUVEC cells in comparison to a non-CDR-H1 glycosylated variant.7. The method of claim 1 , wherein said antibody comprises a CDR-H1 shown in SEQ ID NO: 1 claim 1 , CDR-H2 shown in SEQ ID NO: 2 claim 1 , CDR-H3 shown in SEQ ID NO: 3 claim ...

Engine-braking arrangement for an internal combustion engine with an exhaust-gas turbocharger

In an engine braking arrangement for an internal combustion engine with an exhaust gas turbocharger including a turbine arranged in the engine exhaust duct and a compressor driven by the turbine and arranged in the engine intake duct, a brake valve disposed in the exhaust duct upstream of the turbine and a pressure relief line extending from the exhaust duct upstream of the turbine rotor to an area downstream of the turbine and including a stop valve, the stop valve is a rotationally adjustable rotary valve operable by an actuating device depending on the intake pressure in the intake duct.

Headlight for a vehicle having pixel light source modules forming vertically disposed light patterns

Two headlights are spaced apart from each other in the transverse direction of a vehicle in which they are installed. When the headlights are in position to simultaneously provide light patterns, a first light pattern is located at least partially above a second light pattern in the vertical direction with respect to the installation position of the headlights.

Liquid cooled cylinder head

In an internal combustion engine, with a cylinder head having a coolant space associated with each combustion chamber, wherein the coolant space comprises, for each cylinder of the engine, a first coolant chamber and a second coolant chamber separate from one another, the coolant space has a coolant inlet which extends to the outside and is connected to a coolant supply line for directly supplying coolant from the outside to the first and second coolant chambers.

LIN NETWORK

A LIN network having a plurality of communications units linked for communicating to one another via a communications path, having a master communications unit and at least one slave communications unit, the LIN network having a LIN-LIN interface unit which is arranged to provide a communication link between LIN network and a LIN sub-network according to the LIN standard. 110-. (canceled)11. A LIN network comprising a plurality of communications units linked for communicating to one another via a communications path , having a master communications unit and at least one slave communications unit , the LIN network further comprising a LIN-LIN interface unit arranged to provide a communication link between the LIN network and a LIN sub-network according to a LIN standard.12. The LIN network according to claim 11 , wherein the LIN sub-network is arranged for operating according to the LIN standard.13. The LIN network according to claim 11 , wherein the LIN-LIN interface unit is arranged for operating as a master communications unit and also as a slave communications unit.14. The LIN network according to claim 13 , wherein the LIN-LIN interface unit is arranged for operating as the master communications unit in the LIN sub-network and for operating as the slave communications unit in the LIN network.15. The LIN network according to claim 14 , wherein the LIN-LIN interface unit comprises a LIN transceiver for communicating with the LIN network as the slave communications unit and a LIN transceiver for communicating with the LIN sub-network as the master communications unit.16. The LIN network according to claim 15 , wherein the LIN-LIN interface unit comprises a microcontroller for controlling at least one transceiver from the LIN transceiver for communicating with the LIN network as the slave communications unit and from the LIN transceiver for communicating with the LIN sub-network as the master communications unit.17. The LIN network according to claim 15 , wherein ...

Exhaust gas turbocharger for internal combustion engine enables different flow rates through exhaust gas openings to be set by altering valve body position

The device has an exhaust gas turbine (3), a valve housing forming a common component with an exhaust gas turbine housing and a valve body in the valve housing for opening and closing first and second outlet openings associated with first and second exhaust gas channels. Different flow rates through the openings can be set by altering the valve body position.

Antibody preparation

The present invention relates to the field of biotechnology, and in particular to the field of antibodies. Provided herein are novel methods for removing glycosylated antibody variants from an antibody preparation, an antibody preparation obtained by said method, and a pharmaceutical composition comprising the same.

Turbocharger turbine

Abgasturboladerturbine einer Brennkraftmaschine mit einem in einem Turbinengehäuse angeordneten spiralförmigen Leitkanal, einem Turbinenlaufrad, einem Strömungsspalt zwischen dem Leitkanal und dem Turbinenlaufrad und mit ein Leitgitter bildenden Leitschaufeln, dadurch gekennzeichnet, dass das Leitgitter (10) mit den Leitschaufeln (9) derart axial aus einem in axialer Richtung in dem Turbinengehäuse (4) verschiebbar angeordneten Träger (8, 8') vorstehen, dass die Leitschaufeln (9) im Normalbetrieb in Aussparungen in einem Gehäusewandteil (11a) des Turbinengehäuses (4) gelagert sind, das in Form einer Matrize eine Gegenprofilform zu den Leitschaufeln (9) bildet, dass die Leitschaufeln (9) im Bremsbetrieb der Brennkraftmaschine zur Bildung einer Bremseinrichtung bei einer axialen Verschiebung des Trägers (8, 8') in den Strömungsspalt (3) ragen, und dass die Bremseinrichtung als vorgefertigtes Modul ausgebildet in die Turbine einschiebbar ist, wobei wenigstens das Leitgitter (10) mit den Leitschaufeln (9), der Träger (8, 8') und das Gehäusewandteil (11a), das die Matrize bildet, Teile des Moduls sind. Turbocharger turbine an internal combustion engine with a arranged in a turbine housing spiral Guide channel, a turbine wheel, a flow gap between the guide channel and the turbine runner and vanes forming guide vanes, characterized in that the guide grid (10) with the guide vanes (9) so axially from a in the axial direction in the turbine housing (4) slidably arranged carrier (8, 8 ') protrude that the guide vanes (9) in normal operation in Recesses in a housing wall part (11a) of the turbine housing (4) are stored, which in the form of a die a counter-profile shape to the guide vanes (9) forms that the guide vanes (9) in braking operation the internal combustion engine to form a braking device at a axial displacement of the carrier (8, 8 ') in the flow gap (3) protrude, and that the braking device as a prefabricated module trained in the turbine is ...

Engine brake device for an internal combustion engine with an exhaust gas turbocharger

Testata cilindri con raffreddamento a liquido.

Scheinwerfereinrichtung für ein fahrzeug, fahrzeug sowie verfahren zum betreiben einer scheinwerfereinrichtung eines fahrzeugs

Die Erfindung betrifft eine Scheinwerfereinrichtung (12) für ein Fahrzeug, mit zwei in Einbaulage der Scheinwerfereinrichtung (12) in Fahrzeugquerrichtung (22) voneinander beabstandeten Scheinwerfern (18, 20), welche dazu ausgebildet sind, gleichzeitig ein jeweiliges Lichtbild (24, 26) bereitzustellen, wobei bei einem gleichzeitigen Bereitstellen der Lichtbilder (24, 26) bezogen auf die Einbaulage der Scheinwerfereinrichtung (12) ein erstes der Lichtbilder (24, 26) in vertikaler Richtung (36) zumindest teilweise oberhalb des zweiten Lichtbilds (26) angeordnet ist.

Testata cilindri con raffreddamento a liquido.

Culasse de refroidissement par liquide

L'invention concerne un carter à fluide de refroidissement 7 pour la culasse de moteur à combustion interne, avec au moins une enceinte à fluide de refroidissement 1 chaque fois associée à une chambre de combustion, enceinte présentant au moins une amenée de fluide de refroidissement 4 et au moins une évacuation de fluide de refroidissement 5, l'enceinte à fluide de refroidissement 1 présentant au moins une première chambre à fluide de refroidissement 2 et au moins une deuxième chambre à fluide de refroidissement 3, séparée de celle-ci.

Testata cilindri con raffreddamento a liquido.

Scheinwerfereinrichtung für ein fahrzeug, fahrzeug sowie verfahren zum betreiben einer scheinwerfereinrichtung eines fahrzeugs