Injection tip and method for nucleating and propagating hydraulic fractures from probe rods

An injection tip assembly 10 and methods for use more reliably provide for delivery of fluid substances, such as materials that promote removal, destruction, or isolation of contaminants, into targeted zones within soil or bedrock. The injection tip assembly 10 permits the application of pressurized fluid 163 so as to erode or cut a desired cavity or eroded volume 164 within the subsurface 14, allows for timely observation, adjustment, and control of pressure within the cavity, and directs the delivery of a second substance or fluid that may incorporate desired materials. The consequence of managed erosion and pressure control is to nucleate and propagate a hydraulic fracture of desirable form that optimally delivers remedial agents throughout the targeted formation.

Injection tip and method for nucleating and propagating hydraulic fractures from probe rods

An injection tip assembly 10 and methods for use more reliably provide for delivery of fluid substances, such as materials that promote removal, destruction, or isolation of contaminants, into targeted zones within soil or bedrock. The injection tip assembly permits the application of pressurized fluid 163 so as to erode or cut a desired cavity or eroded volume 164 within the subsurface 14, allows for timely observation, adjustment, and control of pressure within the cavity, and directs the delivery of a second substance or fluid that may incorporate desired materials. The consequence of managed erosion and pressure control is to nucleate and propagate a hydraulic fracture of desirable form that optimally delivers remedial agents throughout the targeted formation.

Injection Tip And Method For Nucleating And Propagating Hydraulic Fractures From Probe Rods

An injection tip assembly 10 and methods for use more reliably provide for delivery of fluid substances, such as materials that promote removal, destruction, or isolation of contaminants, into targeted zones within soil or bedrock. The injection tip assembly 10 permits the application of pressurized fluid 163 so as to erode or cut a desired cavity or eroded volume 164 within the subsurface 14 , allows for timely observation, adjustment, and control of pressure within the cavity, and directs the delivery of a second substance or fluid that may incorporate desired materials. The consequence of managed erosion and pressure control is to nucleate and propagate a hydraulic fracture of desirable form that optimally delivers remedial agents throughout the targeted formation.

Injection Tip And Method For Nucleating And Propagating Hydraulic Fractures From Probe Rods

An injection tip assembly 10 and methods for use more reliably provide for delivery of fluid substances, such as materials that promote removal, destruction, or isolation of contaminants, into targeted zones within soil or bedrock. The injection tip assembly permits the application of pressurized fluid so as to erode or cut a desired cavity or eroded volume within the subsurface , allows for timely observation, adjustment, and control of pressure within the cavity, and directs the delivery of a second substance or fluid that may incorporate desired materials. The consequence of managed erosion and pressure control is to nucleate and propagate a hydraulic fracture of desirable form that optimally delivers remedial agents throughout the targeted formation. 1. A method for nucleating and propagating hydraulic fractures , the method comprising:driving an injection tip into a subsurface, the injection tip having a first channel and a second channel;dispensing a first substance through the first channel of the injection tip and outwardly therefrom to form a cavity in the subsurface;allowing the first substance, and any subsurface material carried thereby as a result of the dispensing of the first substance, to enter the second channel at the injection tip so as to be routed upwardly from the subsurface;thereafter dispensing a second substance through the second channel of the injection tip and outwardly therefrom into the cavity; andcontrolling the pressure in the cavity during the dispensing of the first substance and the dispensing of the second substance, thereby to construct a nucleation cavity of suitable geometry while limiting pressure and thereafter controlling the pressure to cause a hydraulic fracture of desired orientation and form.2. The method of claim 1 , wherein the controlling further comprises:sensing the pressure in the cavity; andvarying the rate of the allowing and/or the dispensing of the first substance and/or the dispensing of the second substance, ...

Methods for Preparing Internally Constrained Peptides and Peptidomimetics

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed. 7. The method according to claim 1 , wherein said reacting is carried out on a solid support.8. A compound prepared according to the method of .9. A compound prepared according to the method of .10. A peptide having one or more stable claim 6 , internally-constrained alpha-helical claim 6 , beta-sheet/beta-turn claim 6 , 3-helical claim 6 , or pi-helical regions.15. The peptide according to claim 10 , wherein said one or more regions comprises a pi helix.16. The peptide according to claim 10 , wherein said one or more regions comprises a beta sheet/beta turn.17. The peptide according to claim 10 , wherein said one or more regions comprises a 3helix.18. The peptide according to claim 10 , wherein said one or more regions comprises an alpha-helix. This application is a divisional of U.S. patent application Ser. No. 12/712,089, filed Feb. 24, 2010, which is a continuation of U.S. patent application Ser. No. 11/128,722, filed May 13, 2005, which claims the benefit of U.S. Provisional Patent Application Ser. No. 60/574,964, filed May 27, 2004, which is hereby incorporated by reference in its entirety.The present invention was made, at least in part, with funding received from the National Institutes of Health, grant number GM073943, and the National Science Foundation, grant numbers MRI-0116222 and CHE-0234863. The U.S. government may have certain rights in this invention.This invention is directed generally to methods for preparing internally constrained peptides and peptidomimetics.Protein secondary structures include 13-sheets/13-turns, 7r-helices, 3-helices, and a-helices.The a-helix is the most common ...

METHODS FOR PREPARING INTERNALLY CONSTRAINED PEPTIDES AND PEPTIDOMIMETICS

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, -helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, -helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed. 7. The method according to claim 1 , wherein said reacting is carried out on a solid support.8. A compound prepared according to the method of .9. A compound prepared according to the method of .10. A peptide having one or more stable claim 6 , internally-constrained alpha-helical claim 6 , beta-sheet/beta-turn claim 6 , 3-helical claim 6 , or pi-helical regions.15. The peptide according to claim 10 , wherein said one or more regions comprises a pi helix.16. The peptide according to claim 10 , wherein said one or more regions comprises a beta sheet/beta turn.17. The peptide according to claim 10 , wherein said one or more regions comprises a 3helix.18. The peptide according to claim 10 , wherein said one or more regions comprises an alpha-helix. This application is a divisional of U.S. patent application Ser. No. 12/712,089, filed Feb. 24, 2010, which is a continuation of U.S. patent application Ser. No. 11/128,722, filed May 13, 2005, which claims the benefit of U.S. Provisional Patent Application Ser. No. 60/574,964, filed May 27, 2004, which is hereby incorporated by reference in its entirety.The present invention was made, at least in part, with funding received from the National Institutes of Health, grant number GM073943, and the National Science Foundation, grant numbers MRI-0116222 and CHE-0234863. The U.S. government may have certain rights in this invention.This invention is directed generally to methods for preparing internally constrained peptides and peptidomimetics.Protein secondary structures include 13-sheets/13-turns, 7r-helices, 3-helices, and a-helices.The α-helix is the most common ...

Electricity generating device for generating electricity downhole in a well.

Well device for generating electrical power in a well

Brönnanordning for generering av elektrisk kraft i en brönn

Well device for generating electrical power in a well

Downhole apparatus for generating electrical power in a well

Electrical generating apparatus is provided which connects to the production tubing. In a preferred embodiment, this apparatus includes a housing having a primary flow passageway in communication with the production tubing. The housing also includes a laterally displaced side passageway communicating with the primary flow passageway such that production fluid passes upwardly towards the surface through the primary and side passageways. A flow diverter may be positioned in the housing to divert a variable amount of production fluid from the production tubing and into the side passageway. In accordance with an important feature of this invention, an electrical generator is located at least partially in or along the side passageway. The electrical generator generates electricity through the interaction of the flowing production fluid.

Source device for generating electrical power in a well

En elektrisk genereringsanordning som er forbundet med produksjonsrøret. I en foretrukket utføringsform omfatter denne anordningen et hus som har en hovedstrømningskanal (22) i forbindelse med produksjonsrøret. Huset omfatter også en sideveis forskjøvet sidekanal (24) som står i forbindelse med hovedstrømningskanalen slik at produksjonsfluid strømmer oppover mot overflaten gjennom hoved- og sidekanalene. En strømningsavleder (30) kan være anordnet i huset for å avlede en variabel mengde av produksjonsfluid fra produksjonsrøret og inn i sidekanalen (24). I samsvar med et viktig trekk ved denne oppfinnelse, er en elektrisk generator (42) plassert i det minste delvis i eller langs sidekanalen. Den elektriske generator (42) genererer elektrisitet ved samvirkning med det strømmende produksj onsfluid. An electrical generating device connected to the production pipe. In a preferred embodiment, this device comprises a housing having a main flow channel (22) in connection with the production pipe. The housing also comprises a laterally offset side channel (24) which communicates with the main flow channel so that production fluid flows upwards towards the surface through the main and side channels. A flow diverter (30) may be provided in the housing to divert a variable amount of production fluid from the production pipe and into the side channel (24). In accordance with an important feature of this invention, an electric generator (42) is located at least partially in or along the side channel. The electric generator (42) generates electricity by cooperating with the flowing production fluid.

Well device for generating electrical power in a well

Downhole apparatus for generating electrical power in a well

Downhole apparatus for generating electrical power in a well

Electrical generating apparatus is provided which connects to the production tubing. In a preferred embodiment, this apparatus includes a housing having a primary flow passageway in communication with the production tubing. The housing also includes a laterally displaced side passageway communicating with the primary flow passageway such that production fluid passes upwardly towards the surface through the primary and side passageways. A flow diverter may be positioned in the housing to divert a variable amount of production fluid from the production tubing and into the side passageway. In accordance with an important feature of this invention, an electrical generator is located at least partially in or along the side passageway. The electrical generator generates electricity through the interaction of the flowing production fluid.

Downhole apparatus for generating electrical power in a well

Electrical generating apparatus is provided which connects to the production tubing. In a preferred embodiment, this apparatus includes a housing having a primary flow passageway in communication with the production tubing. The housing also includes a laterally displaced side passageway communicating with the primary flow passageway such that production fluid passes upwardly towards the surface through the primary and side passageways. A flow diverter may be positioned in the housing to divert a variable amount of production fluid from the production tubing and into the side passageway. In accordance with an important feature of this invention, an electrical generator is located at least partially in or along the side passageway. The electrical generator generates electricity through the interaction of the flowing production fluid.

Well device for generating electrical power in a well

Downhole apparatus for generating electrical power in a well

Electrical generating apparatus is provided which connects to the production tubing. In a preferred embodiment, this apparatus includes a housing having a primary flow passageway in communication with the production tubing. The housing also includes a laterally displaced side passageway communicating with the primary flow passageway such that production fluid passes upwardly towards the surface through the primary and side passageways. A flow diverter may be positioned in the housing to divert a variable amount of production fluid from the production tubing and into the side passageway. In accordance with an important feature of this invention, an electrical generator is located at least partially in or along the side passageway. The electrical generator generates electricity through the interaction of the flowing production fluid.

Well device for generating electrical power in a well

Well device for generating electrical power in a well

Well device for generating electrical power in a well

Well device for generating electrical power in a well

Downhole apparatus for generating electrical power in a well

Mill liner installation

Inhibiting interaction between hif-1.alpha. and p300/cbp with hydrogen bond surrogate-based helices

The present invention relates to peptides having one or more stable, internally constrained .alpha.-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1.alpha.. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1.alpha. with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/ or p300.

Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices

The present invention relates to peptides having one or more stable, internally constrained a helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-la. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-la with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB -binding protein and/or p300.

Methods for preparing internally constrained peptides and peptidomimetics

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.

Methods for Preparing Internally Constrained Peptides and Peptidomimetics

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.

Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices

The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-lα. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-lα with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.

Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices

The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-lα. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-lα with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.

Lateral seal and control system

A downhole multilateral completion tool is disclosed which includes a premachined window joint and a production tube adapted to be moved downhole through the window joint and kicked off into the pre-drilled lateral. A flange and seal form a part of the uphole end of the production tube and provide a 3500 psi seal after the production tube is placed in the lateral. The invention, moreover, includes an energizing sleeve which biases the flange into a sealed position and a packer which by pulling the production tube, enhances the seal of the flange.

Environmentally acceptable acidic lavatory treatment compositions

Aqueous, thickened, acidic compositions which exhibit a pH of about (7) or less preferably (5) or less, and comprise an organic acid constituent selected from formic acid, citric acid and oxalic acid, a thickening constituent or constituents based on one or more gums, particularly xanthan gum which form a thickener system in the inventive composition, and at least one detersive surfactant based on glycoside surfactants, water in an amount of at least 85%wt, preferably at least about 90%wt, and one or more further optional constituents, wherein the compositions exclude: (a) surfactant compounds which include a nitrogen atom in the surfactant compound, and (b) inorganic acids.

Mill liner installation

The present disclosure relates to a method for use in installation of a mill liner, the method including (a) retaining a mounting bolt at least partially within a liner opening extending through the mill liner, (b) positioning the mill liner against a mill shell so that the retained mounting bolt is aligned with a mill shell opening extending through the mill shell, (c) selectively coupling an extraction tool to the mounting bolt, the coupling performed by an operator outside of the mill shell, (d) detaching the mounting bolt from the liner using the extraction tool; (e) pulling the mounting bolt through the mill shell opening so that at least a portion of the mounting bolt protrudes outside of the mill shell, and, (e) securing a fastener onto the mounting bolt to thereby attach the mill liner to the mill.

Method of drilling a window into a casing

An injection tip and method for nucleating and propagating hydaulic fractures from probe rods

An injection tip assembly 10 and methods for use more reliably provide for delivery of fluid substances, such as materials that promote removal, destruction, or isolation of contaminants, into targeted zones within soil or bedrock. The injection tip assembly 10 permits the application of pressurized fluid 163 so as to erode or cut a desired cavity or eroded volume 164 within the subsurface 14, allows for timely observation, adjustment, and control of pressure within the cavity, and directs the delivery of a second substance or fluid that may incorporate desired materials. The consequence of managed erosion and pressure control is to nucleate and propagate a hydraulic fracture of desirable form that optimally delivers remedial agents throughout the targeted formation.

Ｈｅｌｍｈｏｌｔｚ相互画像ペアを用いた表面再構成及びレジストレーション

【課題】 本発明はＨｅｌｍｈｏｌｔｚ相互画像ペアによる表面再構成とレジストレーションに関する。 【解決手段】 画像再構成の方法は、第１画像と対応する相互画像とを含むオブジェクト（３０）に対応する画像のＨｅｌｍｈｏｌｔｚ相互ペアを取得する段階と、Ｈｅｌｍｈｏｌｔｚ相互ペアの取得に関連するイメージングの幾何学的配置を決定する段階と、マッチングのための候補ポイントを選択する段階と、画像の相互ペアでの選択されたポイントと候補ポイントとをマッチングさせる段階とを含む。 【選択図】 図１

Surface reconstruction and registration with a Helmholtz reciprocal image pair