30-04-2015 дата публикации
Номер: US20150118197A1
Принадлежит:
The invention provides a method for producing an electrospun scaffold, comprising electrospinning a polymer or co-polymer onto a template comprising a conductive collector having a three dimensional pattern thereon, wherein said electrospun polymer or co-polymer preferentially deposits onto said three dimensional pattern. 1. A method for producing an electrospun scaffold , comprising electrospinning a polymer or co-polymer onto a template comprising a conductive collector having a three dimensional pattern thereon , wherein said electrospun polymer or co-polymer preferentially deposits onto said three dimensional pattern.2. The method according to claim 1 , wherein said three dimensional pattern is non-conductive.3. The method according to or claim 1 , wherein said three dimensional pattern is dimensioned to provide an electrospun scaffold having at least one cavity therein capable of acting as a stem cell niche.4. The method according to any one of the preceding claims wherein said polymer or co-polymer is biodegradable.5. The method according to claim 4 , wherein said biodegradable polymer or copolymer is biocompatible.6. The method according to or claim 4 , wherein said biodegradable polymer is a collagen claim 4 , a poly alpha ester claim 4 , a polyorthoester or a polyanhydride or a copolymer thereof.7. The method according to claim 6 , wherein said biodegradable polymer or copolymer is cellulose ether claim 6 , cellulose claim 6 , cellulosic ester claim 6 , fluorinated polyethylene claim 6 , phenolic claim 6 , poly-4-methylpentene claim 6 , polyacrylonitrile claim 6 , polyamide claim 6 , polyamideimide claim 6 , polyacrylate claim 6 , polybenzoxazole claim 6 , polycarbonate claim 6 , polycyanoarylether claim 6 , polyester claim 6 , polyestercarbonate claim 6 , polyether claim 6 , polyetheretherketone claim 6 , polyetherimide claim 6 , polyetherketone claim 6 , polyethersulfone claim 6 , polyethylene claim 6 , polyfluoroolefin claim 6 , polyimide claim 6 , ...
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