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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 17. Отображено 17.
08-12-2016 дата публикации

DEVICES FOR AND METHODS OF TREATMENT OF METABOLIC SYNDROMES

Номер: US20160354509A1
Автор: Michael Parlato, Pratik Patel, Kevin Colbert, Ashish Nimgaonkar, Pankaj Pasricha, PARLATO MICHAEL, PATEL PRATIK, COLBERT KEVIN, NIMGAONKAR ASHISH, PASRICHA PANKAJ, Parlato Michael, Patel Pratik, Colbert Kevin, Nimgaonkar Ashish, Pasricha Pankaj
Принадлежит:

Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. In some embodiments, the devices include multilayered bioadhesive patches delivered orally by dissolvable ingestible capsule, wherein various mechanisms are provided for anchoring the bioadhesive patches to the duodenal mucosa. 1. A method for applying a physical barrier to the gastrointestinal (GI) tract of a subject between the intestinal lining and the luminal contents , wherein the physical barrier has one or more of the following effects or characteristics: (a) is created in situ; (b) comprises one or more discrete and non-contiguous components; and (c) preserves significant nutrient absorption capacity within the intestines of the subject; and combinations thereof.2. (canceled)3. The method of claim 1 , wherein the physical barrier regulates one or more neurohormonal signaling pathways.4. The method of claim 1 , wherein the physical barrier is created when a cationic compound combines in situ with the anionic mucins lining the wall of the intestines.5. The method of claim 1 , wherein the subject is afflicted by a metabolic disorder selected from the group consisting of obesity claim 1 , pre-diabetes claim 1 , insulin resistance claim 1 , type 1 diabetes mellitus claim 1 , type 2 diabetes mellitus claim 1 , glucose impairment claim 1 , hypertension claim 1 , and dyslipidemia.6. The method of claim 1 , further comprising applying the physical barrier to limit an area of effective coverage on the lining of the GI tract to a section of the GI tract less than about 30 cm in length claim 1 , wherein the section of the intestines begin at the pyloric sphincter and extends distally toward the jejunum.7. The method of claim 6 , wherein the physical ...

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Номер записи: 1
30-01-2020 дата публикации

NANOFIBER-HYDROGEL COMPOSITES FOR CELL AND TISSUE DELIVERY

Номер: US20200030496A1
Автор: Chang Calvin, Colbert Kevin, Li Xiaowei, Mao Hai-Quan, Martin Russell, Reddy Sashank
Принадлежит:

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material. 138-. (canceled)39. A soft tissue device , comprising:a biologically active material, anda population of substantially non-spherical microbeads comprising a functionalized hyaluronic acid network covalently linked to a plurality of polycaprolactone fibers having a mean length of less than about 200 micrometers, and a crosslinking agent present at a concentration from about 1 mg/mL to about 25 mg/mL, wherein the mean size of the non-spherical microbeads is within the range of about 50 micrometers to about 300 micrometers along the longest dimension,wherein the biologically active material comprises a population of adipose cells, autologous adipose cells, allogenic cells, genetically modified allogenic cells, stem cells, mesenchymal stem cells, genetically modified stem cells, genetically modified allogenic induced pluripotent stem (iPS) cells, genetically modified hypoimmunogenic pluripotent stem cells, adipose stromal vascular fraction, adipose tissue, autologous adipose tissue, lipoaspirate, a derivative thereof, or a combination thereof,wherein the soft tissue device is capable of being implanted or injected into a target tissue of a subject in need thereof.40. The device of claim 39 , wherein the biologically active material is operably encapsulated within the non-spherical microbeads.41. The device of claim 39 , ...

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Номер записи: 2
05-03-2020 дата публикации

NANOFIBER-HYDROGEL COMPOSITES FOR ENHANCED SOFT TISSUE REPLACEMENT AND REGENERATION

Номер: US20200069846A1
Автор: Colbert Kevin, Mao Hai-Quan, Martin Russell, Reddy Sashank
Принадлежит:

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel. 131-. (canceled)32. An injectable population of substantially non-spherical microbeads comprising a functionalized hyaluronic acid network covalently linked to a plurality of polycaprolactone fibers having a mean length of less than about 200 micrometers , and a crosslinking agent present at a concentration from about 1 mg/mL to about 25 mg/mL ,wherein the mean size of the non-spherical microbeads is within the range of about 50 micrometers to about 300 micrometers along the longest dimension,wherein the microbeads are substantially stable at room temperature for at least about 6 months.33. The microbeads of claim 32 , wherein the microbeads are injectable through a 16- to 31-gauge needle.341. A kit comprising a syringe comprising the microbeads of claim 32 , wherein said microbeads are formulated during storage as i) substantially dehydrated beads or ii) hydrated beads that are ready for injection into a target tissue of a subject claim 32 , wherein the dehydrated microbeads are suitable for reconstitution with water claim 32 , saline solution or suitable reconstitution fluid to substantially replace the water mass lost (as measured by weight) prior to injection into a target tissue of a subject such that when the water mass lost is replaced to form the population of microbeads of claim claim 32 , the concentration of the microbeads in the reconstitution fluid is the same or substantially the same as the concentration of microbeads before lyophilization.35. The microbeads of claim 32 , wherein the functionalized hydrogel ...

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Номер записи: 3
03-05-2018 дата публикации

A NON-INVASIVE BIO-FLUID DETECTOR AND PORTABLE SENSOR-TRANSMITTER-RECEIVER SYSTEM

Номер: US20180116515A1
Автор: Acharya Soumyadipta, BUDMAN Joshua, Colbert Kevin, Enten Aaron, Mayya Vaishakhi, Polhemus Ashley
Принадлежит:

The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones. 1. A system for determining hemoglobin level in a subject's blood comprising:a mobile communication device; and a light emitting diode (LED) configured to transmit light through tissue of the subject at four wavelengths;', 'a photosensor configured to receive and measure the light transmitted through the tissue of the subject by the LED; and', 'a communications board configured to trigger the LED to transmit the light transmitted through the tissue of the subject, configured to receive information related to the light transmitted through the tissue of the subject received by the photosensor, and further configured to communicate with the mobile communication device., 'a sensor system comprising2. The sensor system of further comprising an LED driver.3. The sensor system of further comprising a timer coupled to the LED driver.4. The system of further comprising a power source for providing power to the sensor system.5. The system of wherein the power source further comprises one selected from a group consisting of the mobile communication device and a battery.6. The system of wherein the communication board further comprises an amplifier.7. The system of wherein the amplifier further comprises one selected from a group consisting of amplitude modulation (AM) or binary frequency shift keying (BFSK).8. The system of wherein the mobile communication device further comprises a cellular telephone.9. The system of wherein the mobile communication device further comprises a headset-in jack and a headset-out jack.10. The system of ...

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Номер записи: 4
16-08-2018 дата публикации

COMPOSITION AND METHOD FOR TREATMENT OF METABOLIC DISORDERS

Номер: US20180228863A1
Автор: Colbert Kevin, Jozefiak Thomas, NIMGAONKAR Ashish, Parlato Michael, Pasricha Pankaj, Patel Pratik
Принадлежит:

The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. The compositions include components for forming luminal barriers within the gastrointestinal tract of a subject where the barrier is created in-situ via interaction of resident mucin with the mucin-interacting agent. 1. A method for applying a physical barrier to the gastrointestinal (GI) tract of a subject between the intestinal lining and the luminal contents comprising administering to the GI tract of the subject a composition having a mucin-interacting agent , wherein the physical barrier is created in-situ by interaction of resident mucin in the GI tract and the mucin-interacting agent.24-. (canceled)5. The method of claim 1 , wherein the physical barrier is applied to the duodenum claim 1 , or a portion thereof starting from the pyloric sphincter up to about 1 claim 1 , 5 claim 1 , 10 claim 1 , 15 claim 1 , 20 or 30 cm distal along the GI tract therefrom.6. The method of claim 1 , wherein the composition has a retention period in the GI tract of greater than about 0.5 claim 1 , 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , 11 claim 1 , 12 claim 1 , 13 claim 1 , 14 claim 1 , 15 claim 1 , 16 claim 1 , 17 claim 1 , 18 claim 1 , 19 claim 1 , 20 claim 1 , 21 claim 1 , 22 claim 1 , 23 or 24 hours.7. The method of claim 1 , wherein the composition is administered orally to the subject.810-. (canceled)11. The method of claim 1 , wherein the mucin-interacting agent is cationic or polycationic.12. The method of claim 1 , wherein the mucin-interacting agent is one or more agents selected from carbomers claim 1 , hydroxyethylcellulose claim 1 , ...

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Номер записи: 5
23-08-2018 дата публикации

DEVICES FOR AND METHODS OF TREATMENT OF METABOLIC SYNDROMES

Номер: US20180236127A1
Автор: Colbert Kevin, NIMGAONKAR Ashish, Parlato Michael, Pasricha Pankaj, Patel Pratik
Принадлежит:

Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. In some embodiments, the devices include multilayered bioadhesive patches delivered orally by dissolvable ingestible capsule, wherein various mechanisms are provided for anchoring the bioadhesive patches to the duodenal mucosa. 1. A method for applying a physical barrier to the gastrointestinal (GI) tract of a subject between the intestinal lining and the luminal contents , wherein the physical barrier has one or more of the following effects or characteristics: (a) is created in situ; (b) comprises one or more discrete and non-contiguous components; and (c) preserves significant nutrient absorption capacity within the intestines of the subject; and combinations thereof.2. The method of claim 1 , wherein the physical barrier regulates one or more neurohormonal signaling pathways.3. The method of claim 1 , wherein the physical barrier is created when a cationic compound combines in situ with the anionic mucins lining the wall of the intestines.4. The method of claim 1 , wherein the subject is afflicted by a metabolic disorder selected from the group consisting of obesity claim 1 , pre-diabetes claim 1 , insulin resistance claim 1 , type 1 diabetes mellitus claim 1 , type 2 diabetes mellitus claim 1 , glucose impairment claim 1 , hypertension claim 1 , and dyslipidemia.5. The method of claim 1 , further comprising applying the physical barrier to limit an area of effective coverage on the lining of the GI tract to a section of the GI tract less than about 30 cm in length claim 1 , wherein the section of the intestines begin at the pyloric sphincter and extends distally toward the jejunum.6. The method of claim 5 , wherein the physical barrier is ...

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Номер записи: 6
21-12-2017 дата публикации

IMPLANTABLE BODY-DRIVEN SHUNT PUMP

Номер: US20170361074A1
Автор: Camacho Michelle, Colbert Kevin James, NIMGAONKAR Ashish, Petney Matthew, Scavo Laura
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

An implantable, body-driven shunt pump includes a pump body defining a fluid inlet, a fluid outlet and a fluid chamber therebetween; an inlet valve arranged in the fluid inlet, the inlet valve being a one-way valve arranged such that it is operable to allow fluid flow into the fluid chamber and to prevent fluid flow out of the fluid chamber; and an outlet valve arranged in the fluid outlet, the outlet valve being a one-way valve arranged such that it is operable to allow fluid flow out of the fluid chamber and to prevent fluid flow into the fluid chamber. The pump body includes an expandable and contractible component in a portion of the pump body that defines the fluid chamber such that the fluid chamber changes volume in response to a change in pressure of fluid in the fluid chamber. 1. An implantable , body-driven shunt pump , comprising:a pump body defining a fluid inlet, a fluid outlet and a fluid chamber therebetween;an inlet valve arranged in said fluid inlet, said inlet valve being a one-way valve arranged such that it is operable to allow fluid flow into said fluid chamber and to prevent fluid flow out of said fluid chamber; andan outlet valve arranged in said fluid outlet, said outlet valve being a one-way valve arranged such that it is operable to allow fluid flow out of said fluid chamber and to prevent fluid flow into said fluid chamber,wherein said pump body comprises an expandable and contractible component in a portion of said pump body that defines said fluid chamber such that said fluid chamber changes volume in response to a change in pressure of fluid in said fluid chamber.2. The implantable claim 1 , body-driven shunt pump according to claim 1 , wherein said pump body claim 1 , said inlet valve claim 1 , and said outlet valve are all biocompatible materials.3. The implantable claim 1 , body-driven shunt pump according to claim 1 , wherein said implantable claim 1 , body-driven shunt pump has a size suitable to be implantable into an abdominal ...

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Номер записи: 7
14-11-2019 дата публикации

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

Номер: WO2019217767A1
Автор: Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

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Номер записи: 8
14-11-2019 дата публикации

Nanofiber-hydrogel composites for cell and tissue delivery

Номер: WO2019217765A1
Автор: Calvin Chang, Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy, Xiaowei Li
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

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Номер записи: 9
03-12-2020 дата публикации

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

Номер: AU2019265839A1
Автор: Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy
Принадлежит: JOHNS HOPKINS UNIVERSITY

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

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Номер записи: 10
14-11-2019 дата публикации

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

Номер: CA3099733A1
Автор: Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy
Принадлежит: JOHNS HOPKINS UNIVERSITY

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

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Номер записи: 11
14-11-2019 дата публикации

Nanofiber-hydrogel composites for cell and tissue delivery

Номер: CA3099732A1
Автор: Calvin Chang, Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy, Xiaowei Li
Принадлежит: JOHNS HOPKINS UNIVERSITY

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

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Номер записи: 12
23-02-2021 дата публикации

microsphere population, formulation, biomaterial, kit, method for performing a procedure, microsphere complex

Номер: BR112020022853A2
Автор: Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy
Принадлежит: THE JOHNS HOPKINS UNIVERSITY

Um material compósito pode incluir um gel e pelo menos uma nanoestrutura disposta dentro do gel. Um método para curar um defeito de tecido mole pode incluir a aplicação de um material compósito a um defeito de tecido mole, em que o material compósito inclui um gel e uma nanoestrutura disposta dentro do gel. Um método para fabricar um material compósito para uso na cura de defeitos de tecidos moles pode incluir fornecer um gel e a disposição de nanofibras dentro do gel. A composite material can include a gel and at least one nanostructure disposed within the gel. One method to cure a soft tissue defect may include the application of a composite material to a soft tissue defect, in which the material composite includes a gel and a nanostructure disposed within the gel. One method for manufacturing a composite material for use in curing defects soft tissue may include providing a gel and the provision of nanofibers inside the gel.

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Номер записи: 13
03-10-2023 дата публикации

Nanofiber-hydrogel composites for cell and tissue delivery

Номер: US11771807B2
Автор: Calvin Chang, Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy, Xiaowei Li
Принадлежит: JOHNS HOPKINS UNIVERSITY

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

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Номер записи: 14
13-06-2018 дата публикации

Composition and method for treatment of metabolic disorders

Номер: EP3331499A1
Автор: Ashish Nimgaonkar, Kevin COLBERT, Michael PARLATO, Pankaj Pasricha, Pratik Patel, Thomas Jozefiak
Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. The compositions include components for forming luminal barriers within the gastrointestinal tract of a subject where the barrier is created in-situ via interaction of resident mucin with the mucin-interacting agent.

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Номер записи: 15
16-07-2024 дата публикации

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

Номер: US12036339B2
Автор: Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy
Принадлежит: JOHNS HOPKINS UNIVERSITY

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

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Номер записи: 16
15-08-2024 дата публикации

Nanofiber-hydrogel composites for cell and tissue delivery

Номер: US20240269351A1
Автор: Calvin Chang, Hai-quan Mao, Kevin COLBERT, Russell Martin, Sashank Reddy, Xiaowei Li
Принадлежит: JOHNS HOPKINS UNIVERSITY

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

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Номер записи: 17