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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 5. Отображено 5.
06-09-2016 дата публикации

Processes for the preparation of isoindole compounds and isotopologues thereof

Номер: US0009434689B2
Автор: Terrence J. Connolly, Alexander L. Ruchelman, Kelvin H. Y. Yong, Chengmin Zhang, CONNOLLY TERRENCE J, RUCHELMAN ALEXANDER L, YONG KELVIN H Y, ZHANG CHENGMIN, Connolly Terrence J., Ruchelman Alexander L., Yong Kelvin H. Y., Zhang Chengmin
Принадлежит: Celgene Corporation, CELGENE CORP

Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic asymmetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.

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Номер записи: 1
22-08-2013 дата публикации

ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS

Номер: US20130217919A1
Автор: Connolly Terrence J., LEONG William W., RUCHELMAN Alexander L.
Принадлежит: Celgene Corporation

Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds. 2. The process of claim 1 , wherein Rand Rare substituted or unsubstituted (C-C)alkoxy claim 1 , or an isotopologue thereof.3. The process of claim 2 , wherein Ris OMe claim 2 , or an isotopologue thereof claim 2 , Ris OEt claim 2 , or an isotopologue thereof claim 2 , and Ris Me claim 2 , or an isotopologue thereof.4. The process of claim 1 , wherein the metal catalyst contains rhodium.5. The process of claim 4 , wherein the metal catalyst is Rh(cod)OTf.6. The process of claim 1 , wherein the chiral ligand or chiral metal catalyst/ligand complex is (S claim 1 ,R)-t-Bu Josiphos claim 1 , Josiphos SL-J011-2 claim 1 , (S claim 1 ,S)-Me-Duphos claim 1 , (S claim 1 ,S)-Chiraphos claim 1 , (R)-Phanephos claim 1 , (R)—Ru(OAc)(DM-segphos) claim 1 , [(R claim 1 ,R)-Me-BPE]Rh(cod)BF claim 1 , (R)—C-TunePhos claim 1 , (R)—[Rh(cod)TCFP]BF claim 1 , or a stereoisomer thereof.7. The process of claim 6 , wherein the chiral ligand is (S claim 6 ,R)-t-Bu Josiphos.8. The process of claim 1 , wherein the load of catalyst is between about 0.05 mol % and about 5 mol %.9. The process of claim 1 , wherein the molar ratio of the chiral ligand to the metal catalyst is from about 3:1 to about 1:1.10. The process of claim 1 , wherein the hydrogen pressure is between about 15 psig and about 250 psig.11. The process of claim 1 , wherein the solvent is ethyl acetate claim 1 , diethyl ether claim 1 , tetrahydrofuran claim 1 , 1 claim 1 ,4-dioxane claim 1 , acetonitrile claim 1 , dichloromethane claim 1 , chloroform claim 1 , N-methylpyrrolidinone claim 1 , dimethyl formamide claim 1 , dimethyl sulfoxide claim 1 , formic acid claim 1 , acetic acid claim 1 , methanol claim 1 , ethanol claim 1 , isopropanol claim 1 , 2 claim 1 ,2 claim 1 ,2-trifluoroethanol claim 1 , or mixtures ...

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Номер записи: 2
20-03-2014 дата публикации

PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF

Номер: US20140081032A1
Автор: Connolly Terrence J., RUCHELMAN Alexander L., Yong Kelvin H.Y., Zhang Chengmin
Принадлежит: Celgene Corporation

Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange. 4. The process of claim 1 , wherein Yis hydrogen or deuterium; and Yand Yare both hydrogen or both deuterium.5. The process of claim 4 , wherein Yis hydrogen or deuterium; and Yand Yare both hydrogen or both deuterium claim 4 , wherein not all of Y claim 4 , Y claim 4 , and Yare hydrogen.7. The process of claim 1 , wherein Rand Rare substituted or unsubstituted (C-C)alkoxy claim 1 , or an isotopologue thereof.8. The process of claim 7 , wherein Ris OMe enriched with 0 claim 7 , 1 claim 7 , 2 claim 7 , or 3 deuterium claim 7 , and Ris OEt enriched with 0 claim 7 , 1 claim 7 , 2 claim 7 , 3 claim 7 , 4 claim 7 , or 5 deuterium.9. The process of claim 8 , wherein Ris OCD claim 8 , and Ris OEt.10. The process of claim 8 , wherein Ris OCD claim 8 , and Ris OCDCD.11. The process of claim 1 , wherein Ris Me enriched with 0 claim 1 , 1 claim 1 , 2 claim 1 , or 3 deuterium.14. The process of claim 1 , wherein R is methyl enriched with 0 claim 1 , 1 claim 1 , 2 claim 1 , or 3 deuterium or cyclopropyl enriched with 0 claim 1 , 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5 deuterium.15. The process of claim 1 , wherein the hydrogenation in step (a) occurs with hydrogen gas.16. The process of claim 1 , wherein the hydrogenation in step (a) occurs with deuterium gas.17. The process of claim 1 , wherein the hydrogenation in step (a) occurs in a solvent containing exchangeable proton for proton-deuterium exchange.18. The process of claim 17 , wherein the solvent containing exchangeable proton for proton-deuterium exchange is 2 claim 17 ,2 claim 17 ,2-trifluoroethanol.19. The process of claim 1 , wherein the hydrogenation in step (a) occurs in a solvent containing ...

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Номер записи: 3
02-07-2015 дата публикации

PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF

Номер: US20150183739A1
Автор: Connolly Terrence J., RUCHELMAN Alexander L., Yong Kelvin H.Y., Zhang Chengmin
Принадлежит:

Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic assymetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange. 125-. (canceled)27. The process of claim 26 , wherein Yis hydrogen or deuterium; and Yand Yare both hydrogen or both deuterium.28. The process of claim 27 , wherein Yis hydrogen or deuterium; and Yand Yare both hydrogen or both deuterium claim 27 , wherein not all of Y claim 27 , Y claim 27 , and Yare hydrogen.30. The process of claim 26 , wherein Rand Rare substituted or unsubstituted (C-C)alkoxy claim 26 , or an isotopologue thereof.31. The process of claim 30 , wherein Ris OMe enriched with 0 claim 30 , 1 claim 30 , 2 claim 30 , or 3 deuterium claim 30 , and Ris OEt enriched with 0 claim 30 , 1 claim 30 , 2 claim 30 , 3 claim 30 , 4 claim 30 , or 5 deuterium.32. The process of claim 31 , wherein Ris OCD claim 31 , and Ris OEt.33. The process of claim 31 , wherein Ris OCD claim 31 , and Ris OCDCD.34. The process of claim 26 , wherein Ris Me enriched with 0 claim 26 , 1 claim 26 , 2 claim 26 , or 3 deuterium.37. The process of claim 26 , wherein the hydrogenation in step (a) occurs with hydrogen gas.38. The process of claim 26 , wherein the hydrogenation in step (a) occurs with deuterium gas.39. The process of claim 26 , wherein the hydrogenation in step (a) occurs in a solvent containing exchangeable proton for proton-deuterium exchange.40. The process of claim 39 , wherein the solvent containing exchangeable proton for proton-deuterium exchange is 2 claim 39 ,2 claim 39 ,2-trifluoroethanol.41. The process of claim 26 , wherein the hydrogenation in step (a) occurs in a solvent containing exchangeable deuterium for proton-deuterium exchange.42. The process of claim 41 , wherein the solvent containing exchangeable deuterium for proton-deuterium exchange is 2 claim ...

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Номер записи: 4
25-08-2014 дата публикации

Composiciones farmaceuticas de 7-(6- (2-hidroxi propan -2-il) piridin -3-il) -1- ((trans) -4-metoxiciclohexil ) -3, 4- dihidropiracino [2,3-b] piracin-2 (1h) -ona, una forma solida de las mismas y metodos de su uso

Номер: CR20140260A
Автор: Amanda N Miklos, Anil Menon, Cohen Benjamin, Jean Xu Warren, Juan Antonio GAMBOA, Kevin J Klopfer, LEE THOMAS, LI Ying, Michael Kreilein Mathew, Nathan BOERSEN, Terrence J Connolly, Wan Hui Ho, Wet-Hwaleong William
Принадлежит: Signal Pharm Llc

Se proporcionan en la presente composiciones de 7-(6-(2-hidroxipropan-2-il)piridin-3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pirazin-2(1H)-ona, formas sólidas, isotopólogos, y metabolitos de los mismos y métodos de su uso para el tra

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Номер записи: 5