Methods and compositions for gray leaf spot resistance in corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.

Pepper plants and fruits with improved nutritional value

The present invention concerns Capsicum annuum plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles.

Methods and compositions for Goss' Wilt resistance in corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.

PEPPER PLANTS AND FRUITS WITH IMPROVED NUTRITIONAL VALUE

The present invention concerns plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles. 1Capsicum annuum. A blocky fruit type pepper plant bearing extreme dark green color fruit at immature harvestable stage , said plant comprising two genetic determinants directing or controlling expression of said extreme dark green color in the pepper fruit of the pepper plant wherein said two genetic determinants are represented by two QTL ,{'i': 'Capsicum annuum', 'wherein the said genetic determinants are the genetic determinants of ancho San Luis′,'}wherein the first QTL, QTL1, is genetically or physically linked to at least one of marker loci SP436 and SP626,and the second QTL, QTL2, is genetically or physically linked to at least one of marker loci SP693 and SP694, andwherein said pepper plant is homozygous at QTL1 and QTL2, and a content in Chlorophyll B greater than 6 μg/g of fresh weight,', 'a content in Chlorophyll A greater than 20 μg/g of fresh weight,', 'a content in lutein greater than 5 μg/g of fresh weight, and', 'a content in violaxanthin greater than 2 μg/g of fresh weight., 'wherein the extreme dark green color is associated with the following physicochemical characteristics of the pepper fruits at immature harvestable stage2. A blocky fruit type pepper plant according to claim 1 , wherein marker locus SP436 can be identified in a PCR by amplification of a DNA fragment with the pair of oligonucleotide primers: forward primer of SEQ ID NO: 1 and reverse primer of SEQ ID ...

Methods & Compositions for Selection of Loci for Trait Performance & Expression

The present invention provides novel methods and compositions for the identification and selection of loci modulating transgene performance and expression in plant breeding. In addition, methods are provided for screening germplasm entries for the performance and expression of at least one transgene.

METHODS AND APPARATUSES FOR ATTACHING TISSUE TO ORTHOPAEDIC IMPLANTS

Methods and apparatuses for attaching tissue structures to orthopaedic implants. In one exemplary embodiment, the methods and apparatuses are used to attach soft tissue and/or bone to a proximal tibial implant. In another exemplary embodiment, the methods and apparatuses are used to attach soft tissue and/or bone to a proximal femoral implant. 116-. (canceled)17. A segmental femoral orthopaedic implant configured for attachment to a tissue structure , the segmental femoral orthopaedic implant comprising:a body comprising an anterior surface, a posterior surface, a lateral surface, a medial surface, a proximal end, and a distal end, the lateral surface of the body comprising a porous material;a neck that extends medially from the body, the neck configured to support a head for articulation with an acetabular component; anda protrusion that projects medially from the body beneath the neck, the protrusion defining at least one suture throughbore.18. The segmental femoral orthopaedic implant of claim 17 , wherein the neck is one of an integral component that is integrally coupled to the body and a modular component that is removably coupled to the body.19. The segmental femoral orthopaedic implant of claim 17 , wherein the protrusion comprises a porous surface.20. The segmental femoral orthopaedic implant of claim 17 , wherein the distal end of the body is substantially cylindrical in shape and the protrusion projects radially outwardly from the cylindrical body.21. The segmental femoral orthopaedic implant of claim 17 , further comprising at least one washer having a clamping surface claim 17 , the at least one washer coupled to the body with the clamping surface facing the lateral surface of the body claim 17 , wherein the at least one washer is configured to clamp the tissue structure between the clamping surface and the lateral surface of the body.22. The segmental femoral orthopaedic implant of claim 21 , wherein the at least one washer is rotatably coupled to the ...

Plants and seeds of corn variety cv547369

According to the invention, there is provided seed and plants of the corn variety designated CV547369. The invention thus relates to the plants, seeds and tissue cultures of the variety CV547369, and to methods for producing a corn plant produced by crossing a corn plant of variety CV547369 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV547369 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV547369.

Methods and Compositions for Gray Leaf Spot Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 2. The method according to claim 1 , wherein the at least one corn plant genotyped in step (a) and/or the at least one corn plant selected in step (b) is a corn plant from a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein genotyping is effected in step (a) by determining the allelic state of at least one of said corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant to introgress GLS resistance into a corn germplasm.9. The method of claim 2 , wherein said population is a haploid breeding population.10. A method of introgressing a Gray Leaf Spot (GLS) resistance QTL allele into a corn plant comprising:a) screening a population with at least one nucleic acid marker to determine if one or more corn plants from the population comprise(s) an allele of said ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 120-. (canceled)23. The method of claim 22 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed in the presence of a solvent.24. The method of claim 23 , wherein the solvent comprises dichloroethane and tBuOH.25. The method of claim 24 , wherein the ratio of dichloroethane to tBuOH is 1:1.26. The method of claim 22 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed in the presence of a base.27. The method of claim 26 , wherein the base is Hunig's base.28. The method of claim 22 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed in a sealed container.29. The method of claim 22 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed at elevated temperature.30. The method of claim 29 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed at 88° C.31. The method of claim 22 , wherein the reaction of the compound of Formula (V) and the compound of Formula (VI) is performed for 1.5 hour.32. The method of claim 22 , further comprising isolating the compound of Formula (IV) claim 22 , wherein isolating the compound of Formula (IV) comprises precipitating the compound of Formula (IV) from the reaction mixture.33. The method of claim 32 , wherein isolating the compound of Formula (IV) comprises dilution of the reaction mixture with EtO/EtOH.34. The method of claim 33 , wherein the ratio of EtO/EtOH is 10:1.35. The method of claim 32 , wherein the isolation of the compound of Formula (IV) further comprises filtration.36. The method of claim 22 , wherein the compound of Formula (IV) is converted into a salt thereof.37. The method of claim 36 , wherein the salt is the HCl salt.38. The method of claim 37 , wherein the HCl salt is formed by a reaction with 4M HCl in dioxane.39. The method of ...

Methods and Compositions for Goss' Wilt Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Goss' Wilt resistance in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NOs: 13, 19, 24, 27, 36, 50, 53, 90, 94, 95, 97, 99, 101, 102, 106, 110, 111, 119, 121, 122, 124, 128, 130-132, 136, 138, 141, 146, 153, 158-160, 162, 164, 166, 169, 172, 175, 177, 186, 200, 202, 203, 207, 208, 215, 216, 218, 220, 224, 228, 231-236, 244, 248, 250, 252, 256, 257, 260, 265-267, 271-274, 278, 279, 282, 287, 289, 294-296, 299, 317, 320, 332-334, 337, 347, 355, 362, 363, 366-368, 370, 371, 375, 381, 382, 392, 395, 401, 408, 409, 411, 412, 422, 423, 429, 430, 433, 438, 440, 447, 474, 476, 479, 480, 482, 486, 490, 493, 498, 500, 525, 530, 533, 556, 566, 582, 585, 587, 589, 593, 594, 599, 611, 618, 621, 623, 629, 630, 632, 637, 639, 646, 649, 650, 657, 665, 669, 678, 679, 688, 690, 704, 709, 710, 717, 719-721, 726, 727, 733, 734, 744, 746, 758, 760, 764, 768, 773, 792, 793, 812, 821, 825, 835, 844, 846, 850, 854, 856-858, 874, 876, 880, 882, 885, 893, 896, 897, 915, 926, 940, 942, 949, 951, 957, 963, 964, 974, 976, 981, 983, 990, 997, 999, 1000, 1015, 1016, 1027, 1043, 1049, 1053, 1054, 1056, 1075, 1081, 1087, 1088, 1098-1100, 1104, 1105, 1108, 1110, 1115, 1122, 1131, 1133, 1142, 1143, 1145, 1146, 1148, 1149, 1159, 1168, 1174, 1184, 1186, 1196, 1204, 1212, 1215, 1229, 1234-1302, and 1303, andb) selecting at least one corn plant comprising an allele of at least one of said markers that is associated ...

Load monitoring nodes and apparatuses

Load monitoring nodes and apparatuses are disclosed. According to an aspect, apparatus for load monitoring at a power measurement input may include a load monitoring node configured to capture load data at a power measurement input of an electrical outlet. The node may communicate the captured load data to a network communications device. The apparatus may also include a frame configured to hold the load monitoring node. Further, the apparatus may include an attachment mechanism configured to attach the frame to the electrical outlet.

LOAD MONITORING SYSTEMS, NODES, AND RELATED METHODS

Load monitoring systems, nodes, and related methods are disclosed. According to an aspect, a load monitoring system includes multiple load monitoring nodes. Each node is in communication with a power measurement input and is configured to capture load data at the respective power measurement input. The system includes a network communications device configured to receive the captured load data from each of the load monitoring nodes and to communicate the captured load data to a remote computing device. 1. A load monitoring system comprising:a plurality of load monitoring nodes each being in communication with a power measurement input and each being configured to capture load data at the respective power measurement input; anda network communications device configured to receive the captured load data from each of the load monitoring nodes and to communicate the captured load data to a remote computing device.2. The load monitoring system of claim 1 , wherein the plurality of load monitoring nodes includes first and second load monitoring nodes claim 1 , andwherein the first load monitoring node communicates its respective captured load data to the second load monitoring node, andwherein the second load monitoring node includes a relay function configured to communicate the captured load data of the first load monitoring node to the network communications device.3. The load monitoring system of claim 1 , wherein each of the load monitoring nodes is configured to communicate the captured load data to the network communications device.4. The load monitoring system of claim 1 , wherein each of the load monitoring nodes is configured to periodically communicate the captured load data to the network communication device.5. The load monitoring system of claim 1 , further comprising a wireless local area network (WLAN) including the load monitoring nodes claim 1 , andwherein the network communications device is configured with gateway functions for managing communications ...

METHODS OF PREPARING CLUSTERBORON

New methods are provided for synthesis of ClusterBoron® (BH). Preferred methods of the invention include generation of the conjugate acid of BHand degradation of the acid in solution to produce BHin high yields and high purity. The invention further provides isotopically enriched boranes, particularly isotopically enriched BHand BH. 1. A method of synthesizing octadecaborane (BH) , the method comprising:{'sub': 20', '18', '2', '20', '18', '2, 'sup': '2−', '(a) contacting the salt of borane anion BHwith an acid to produce HBH\ue8a0xHO; and'}{'sub': 18', '22, '(b) removing water from the reaction vessel in the presence of a BHsolubilizing solvent that remains essentially chemically inert in the system.'}2. A method of synthesizing octadecaborane (BH) , the method comprising:{'sub': 20', '18', '2', '20', '18', '2, 'sup': '2−', '(a) contacting the salt of borane anion BH in solvent with an acid to produce a solution of HBH\ue8a0xHO;'}{'sub': 2', '20', '18', '2, '(b) optionally concentrating the mixture comprising HBH\ue8a0xHO;'}{'sub': 18', '22, '(c) removing water from the reaction vessel in the presence of a BHsolubilizing solvent that remains essentially chemically inert in the system; and'}{'sub': 18', '22, '(d) optionally separating insoluble byproducts from the reaction mixture through (i) filtration and/or (ii) concentration of reaction solvent, dissolution of BHinto solvent and filtration of byproducts.'}3. The method of further comprising isolating BHthrough removal of solvent.4. The method of wherein the BHsalt is an alkyl ammonium salt with a cation formula of [NRRRR] claim 2 , wherein{'sup': 1', '2', '3', '1', '2', '3, 'sub': 1-20', '6-10', '7-10, 'R, R, and Rare independently selected from the group consisting of hydrogen, Calkyl, Caryl, Caralkyl, or any two of R, R, or Rtaken in combination form a heterocyclic ring; and'}{'sup': '4', 'sub': 1-20', '6-10, 'Ris selected from hydrogen, Calkyl, or Caryl;'}5. The method of or wherein the acid is an organic acid ...

Plants and seeds of hybrid corn variety ch900774

According to the invention, there is provided seed and plants of the hybrid corn variety designated CH900774. The invention thus relates to the plants, seeds and tissue cultures of the variety CH900774, and to methods for producing a corn plant produced by crossing a corn plant of variety CH900774 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH900774.

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH458430

According to the invention, there is provided seed and plants of the hybrid corn variety designated CH458430. The invention thus relates to the plants, seeds and tissue cultures of the variety CH458430, and to methods for producing a corn plant produced by crossing a corn plant of variety CH458430 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH458430. 1. A seed of the hybrid corn variety CH458430 , produced by crossing a first plant of variety CV683228 with a second plant of variety CV760185 , wherein representative seed of said varieties CV683228 and CV760185 have been deposited under ATCC Accession numbers PTA-______ and PTA-11790 , respectively.2. A plant of the hybrid corn variety CH458430 grown from the seed of .3. A plant part of the plant of .4. The plant part of claim 3 , further defined as an ear claim 3 , ovule claim 3 , pollen or cell.5. A composition comprising the seed of comprised in plant seed growth media.6. The composition of claim 5 , wherein the growth media is soil or a synthetic cultivation medium.7. The seed of claim 1 , further comprising at least a first transgene.8. The seed of claim 7 , wherein the transgene confers a trait selected from the group consisting of male sterility claim 7 , herbicide tolerance claim 7 , insect resistance claim 7 , disease resistance claim 7 , waxy starch claim 7 , modified fatty acid metabolism claim 7 , modified phytic acid metabolism claim 7 , modified carbohydrate metabolism and modified protein metabolism.9. A method of producing hybrid corn seed comprising crossing a plant of variety CV683228 with a plant of variety CV760185 claim 7 , wherein representative seed of variety CV683228 and variety CV760185 have been deposited under ATCC Accession numbers PTA-______ and PTA-11790 claim 7 , respectively.10. A seed of the hybrid corn variety CH458430 comprising at least a first single locus conversion claim 7 , ...

PLANTS AND SEEDS OF CORN VARIETY CV683228

According to the invention, there is provided seed and plants of the corn variety designated CV683228. The invention thus relates to the plants, seeds and tissue cultures of the variety CV683228, and to methods for producing a corn plant produced by crossing a corn plant of variety CV683228 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV683228 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV683228. 1. A plant of corn variety CV683228 , wherein a sample of seed of corn variety CV683228 has been deposited under ATCC Accession No. PTA-120303.2. A plant part of the plant of .3. The plant part of claim 2 , further defined as pollen claim 2 , an ovule or a cell.4. A seed of corn variety CV683228 claim 2 , wherein a sample of seed of corn variety CV683228 has been deposited under ATCC Accession No. PTA-120303.5. The seed of claim 4 , further comprising a transgene.6. A corn plant that expresses all of the physiological and morphological characteristics of the corn variety CV683228 claim 4 , wherein a sample of seed of corn variety CV683228 has been deposited under ATCC Accession No. PTA-120303.7. A composition comprising a seed of corn variety CV683228 comprised in plant seed growth media claim 4 , wherein a sample of seed of corn variety CV683228 has been deposited under ATCC Accession No. PTA-120303.8. The composition of claim 7 , wherein the growth media is soil or a synthetic cultivation medium.9. An F1 hybrid seed produced by crossing a plant of corn variety CV683228 according to with a second claim 1 , distinct corn plant to produce seed.10. The F1 hybrid seed of claim 9 , wherein said plant of corn variety CV683228 further comprises a transgene that is inherited by the seed.11. An F1 hybrid plant grown from the seed of .12. A plant ...

Methods and Compositions for Gray Leaf Spot Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 1. A method of creating a population of corn plants comprising at least one allele associated with Gray Leaf Spot (GLS) resistance comprising SEQ ID NO: 157 , 167 , or 389 , the method comprising the steps of:a) genotyping a first population of corn plants;b) selecting from said first population one or more corn plants containing said allele; andc) producing from said selected corn plants a second population.2. The method according to claim 1 , wherein the first population of corn plants genotyped in step (a) is a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein said genotyping is effected in step (a) by determining the allelic state of at least one corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant to introgress GLS resistance into a corn germplasm.9. ...

CONTAINER SYSTEM FOR STORING REMAINS

A container system for storing remains is provided, including a rigid storage vessel defining an inner chamber for receiving remains. The system includes at least one display frame member outside the rigid storage vessel for displaying information, such as a picture. A cap is provided proximate the storage vessel, wherein the cap defines at least one storage area for receiving an object. 1. A container system for storing remains , comprising:a base;an inner container defining a cavity and connected to the base;a rigid storage vessel positioned in the cavity defined by the inner container, the rigid storage vessel defining an inner chamber for receiving the remains; andat least one frame member positioned outside the inner container for displaying information.2. The container system of claim 1 , further comprising a closure for sealing said storage vessel.3. The container system of claim 1 , further comprising a cap adapted to be removably attached to said inner container.4. The container system of claim 3 , wherein said cap defines a display area for displaying information.5. The container system of claim 3 , wherein said cap defines a cavity for receiving an object.6. The container system of claim 1 , wherein said at least one frame member is adapted for receiving information selected from the group consisting of photographs claim 1 , printed documents claim 1 , and mementos.7. The container system of claim 1 , wherein said at least one frame member is adapted for displaying digital images.8. The container system of claim 1 , further comprising an audio system for playing a sound recording.9. The container system of claim 1 , wherein the storage vessel is removably secured within said housing.10. The container system of claim 1 , wherein said at least one frame member is formed integral with said base.11. The container system of claim 1 , wherein said base has at least three sides.12. A container system for storing remains claim 1 , comprising:a rigid storage ...

IMPRESSION SYSTEM

An impression system is provided for capturing an anatomical impression of an animal. The impression system comprises a foam that substantially retains an impression after application of pressure and subsequent removal of pressure and a case having a recessed area for receiving the foam and a case for retaining the foam therein. The system further comprises a cover having a viewing pane attachable to the case for providing viewing of the foam when closed. 1. An impression system for capturing an anatomical impression , comprising:a foam that substantially retains an anatomical impression after application of pressure and subsequent removal of pressure; anda case having a recessed area for receiving the foam.2. The system of claim 1 , further comprising a cover attached to the case claim 1 , wherein the cover is movable between an open position and a closed position.3. The system of claim 2 , wherein the cover is hingedly attached to the case.4. The system of claim 1 , wherein the cover comprises a rigid material.5. The system of claim 2 , wherein the cover includes a display area.6. The system of claim 2 , wherein the cover further comprises an edge to engage with the case when the cover is in a closed position.7. The system of claim 1 , wherein the foam is a podiatric foam.8. The system of claim 7 , wherein the podiatric foam is dry.9. The system of claim 1 , wherein the foam is a closed-cell foam.10. The system of claim 1 , wherein the foam comprises a phenolic plastic.11. The system of claim 1 , wherein the foam substantially retains an impression without the use of heat.12. The system of claim 1 , wherein the anatomical impression is of an animal.13. An impression system for capturing an anatomical impression claim 1 , comprising:a foam that substantially retains an anatomical impression after application of pressure and subsequent removal of pressure;a case having a recessed area for receiving the foam; anda cover for the case.14. The system of claim 13 , ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 120-. (canceled)22. The method of claim 21 , wherein the reaction is performed in the presence of a catalyst.23. The method of claim 22 , wherein the catalyst is 10% palladium on carbon.24. The method of claim 21 , wherein the reaction is performed in the presence of a solvent.25. The method of claim 24 , wherein the solvent is 2N methanolic NH.26. The method of claim 21 , wherein the reaction of the compound of Formula (B1) with hydrogen is performed under hydrogen pressure.27. The method of claim 26 , wherein the pressure is 45 psi.28. The method of claim 21 , wherein the reaction is performed in a Parr reactor.29. The method of claim 21 , wherein the reaction is performed at ambient temperature.30. The method of claim 29 , wherein the temperature is 25° C.31. The method of claim 21 , wherein the reaction is performed for 3 hours.32. The method of claim 21 , further comprising isolating the compound of Formula (B2) claim 21 , wherein isolating the compound of Formula (B2) comprises filtration.33. The method of claim 32 , wherein the filtration is through Celite.35. The method of claim 34 , wherein the reaction is performed in the presence of a solvent.36. The method of claim 35 , wherein the solvent is acetonitrile.37. The method of claim 34 , wherein the reaction is performed in the presence of a base.38. The method of claim 37 , wherein the base is cesium carbonate.39. The method of claim 36 , wherein the reaction is added at ambient temperature.40. The method of claim 39 , wherein the temperature is 25° C.41. The method of claim 34 , wherein the reaction is performed at elevated temperature.42. The method of claim 41 , wherein the temperature is 80° C.43. The method of claim 34 , further comprising isolating the compound of Formula (B1) claim 34 , wherein isolating the compound of Formula (B1) comprises decreasing the temperature of the reaction mixture to ambient temperature.44. The method of claim ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 2. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base.3. The method of claim 2 , wherein the base is diethylamine (DIEA).4. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours.5. The method of claim 1 , wherein the reaction is performed in the presence of a solvent.6. The method of claim 5 , wherein the solvent is 1 claim 5 ,2-dichloroethane (DCE):t-BuOH.7. The method of claim 6 , wherein the 1 claim 6 ,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol.8. The method of claim 1 , wherein the temperature is 80° C.9. The method of claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature.10. The method of claim 9 , wherein the temperature is 25° C.11. The method of claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc.12. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water.13. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO.14. The method of claim 9 , wherein isolating the compound of Formula (1) comprises filtration. This patent application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 60/912,597, filed Apr. 18, 2007.This invention relates to novel sulfonyl amide derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.It ...

Sulfonyl amide derivatives for the treatment of abnormal cell growth

wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

PEPPER PLANTS AND FRUITS WITH IMPROVED NUTRITIONAL VALUE

The present invention concerns plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles. 1Capsicum annuum. A blocky fruit type pepper plant bearing extreme dark green color fruit at immature harvestable stage , said plant comprising two genetic determinants directing or controlling expression of said extreme dark green color in the pepper fruit of the pepper plant wherein said two genetic determinants are represented by two QTL ,{'i': 'Capsicum annuum', 'wherein the said genetic determinants are the genetic determinants of ancho ‘San Luis’,'}wherein the first QTL, QTL1, is genetically or physically linked to at least one of marker loci SP436 and SP626,wherein marker locus SP436 can be identified in a PCR by amplification of a DNA fragment with a pair of oligonucleotide primers: forward primer of SEQ ID NO: 1 and reverse primer of SEQ ID NO: 2 and probe of SEQ ID NO: 9, andmarker locus SP626 can be identified in a PCR by amplification of a DNA fragment with a pair of oligonucleotide primers: forward primer of SEQ ID NO: 3 and reverse primer of SEQ ID NO: 4 and probe of SEQ ID NO: 10,and wherein the second QTL, QTL2, is genetically or physically linked to at least one of marker loci SP693 and SP694,wherein marker locus SP693 can be identified in a PCR by amplification of a DNA fragment with a pair of oligonucleotide primers: forward primer of SEQ ID NO: 5 and reverse primer of SEQ ID NO: 6 and probe of SEQ ID NO: 11, andmarker locus SP694 can be identified in a PCR by ...

Method of Cooling Nuclear Reactor and Nuclear Reactor Including Polyhedral Boron Hydride or Carborane Anions

A method of cooling a nuclear reactor core is disclosed. The method includes contacting the nuclear reactor core with an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions. Nuclear reactors are also disclosed. The nuclear reactor has a neutron moderator that is an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions, or the nuclear reactor has an emergency core cooling system including a vessel containing a volume of an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions. The nuclear reactor can also have both an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions as a neutron moderator and an emergency core cooling system that includes an aqueous solution comprising at least one of polyhedral boron hydride an ions or carborane anions.

METHODS AND COMPOSITIONS FOR GRAY LEAF SPOT RESISTANCE IN CORN

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Gray Leaf Spot (GLS) resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NO:1-62, 64-70, 72-156, 158-172, 174-187, 189-377, 379, 380, 382-409, 411-459, 461-1233, 1360 and 1361, andb) selecting at least one corn plant comprising an allele of at least one of said markers associated with Gray Leaf Spot (GLS) resistance.2. The method according to claim 1 , wherein the at least one corn plant genotyped in step (a) and/or the at least one corn plant selected in step (b) is a corn plant from a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein genotyping is effected in step (a) by determining the allelic state of at least one of said corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back ...

COATING WITH CONDUCTIVE AND CORROSION RESISTANCE CHARACTERISTICS

The invention relates to an article, such as a plate for a use in a fuel cell, which has a base onto which a coating is applied which is electrically conductive and which includes a substantially carbon material layer and at least one intermediate layer which can be a nitride, carbide, metal and metal alloy. The multilayer coating which is formed allows the protection of the article in an efficient and effective manner. 1: An article , said article including a base or plate formed of an electrically conductive material and a coating applied thereto to cover at least part of the external surface of the same , said coating including , at least it's external face , a conductive , substantially carbon material layer and/or a noble metal layer and intermediate said external face and the base there is provided at least one intermediate layer of one or more electrically conductive materials , and wherein at least part of the coating is graded and the substantially carbon material is of a substantially graphitic sp2 form at least at and/or adjacent to the external surface of the coating.2: An article according to wherein at least one intermediate layer is formed of nitride and/or carbide material.3: An article according to wherein the nitride and/or carbide layer provides any claim 2 , or any combination of claim 2 , adhesion for the coating to the base claim 2 , a barrier layer for the base material and/or corrosion protection for the base material.4: An article according to wherein the coating claim 1 , in addition claim 1 , or alternatively claim 1 , to the nitride and/or carbide layer includes a metal or metal alloy layer and/or a metal oxide layer.5. (canceled)6: An article according to wherein the transition between the substantially carbon material layer and at least one intermediate layer is graded.7. (canceled)8: An article according to wherein the coating is graded on the basis of density and/or the sp2/sp3 carbon bond ratio in the substantially carbon material ...

SPECIALLY DESIGNED PHASED ARRAY TRANSDUCER FOR THE INSPECTION OF FASTENER HOLES AND ADJACENT STRUCTURE WITHOUT THE REMOVAL OF THE FASTENER

A phased array transducer for inspecting a fastener hole and adjacent structure to identify defects and determine hole integrity without removing the fastener from the hole. The phased array transducer includes a plurality of transducer elements, where one of the transducer elements is used to align the transducer to the hole, one group of the remaining transducer elements inspects the entire thickness of the structure at one side of the fastener and another group of the remaining transducer elements inspects the entire thickness of the structure at an opposite side of the fastener. 1. A phased array transducer for inspecting a fastener hole and adjacent structure without removing a fastener from the hole , said transducer comprising:a body including a upper body portion and a lower body portion; anda plurality of transducer elements positioned in the body, wherein at least one of the transducer elements is a centering transducer element that locates the center of the hole or fastener, said plurality of transducer elements also including two groups of inspection transducer elements, where a first group of the inspection transducer elements inspects one side of the hole and a second group of the inspection transducer elements inspects an opposite side of the hole.2. The transducer according to wherein the body includes a semi-circular cut-out section configured to accept a portion of the fastener.3. The transducer according to wherein the lower body portion is made of a clear or translucent plastic.4. The transducer according to wherein the body is rectangular.5. The transducer according to wherein the plurality of inspection transducer elements is thirty-two transducer elements claim 1 , where the first group of inspection transducer elements is sixteen elements and the second group of inspection transducer elements is sixteen elements.6. The transducer according to further comprising a magnet positioned in the lower body portion.7. The transducer according to ...

CDK2/4/6 Inhibitors

This invention relates to compounds of general Formula (I) 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris F claim 1 , Cl claim 1 , C-Calkyl or C-Cfluoroalkyl claim 1 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare independently H claim 1 , OH or C-Calkyl.6. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.7. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris F claim 5 , Cl claim 5 , C-Calkyl or C-Cfluoroalkyl claim 5 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.8. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Rand Rare independently H claim 5 , OH or C-Calkyl.10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.11. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Ris F claim 9 , Cl claim 9 , C-Calkyl or C-Cfluoroalkyl claim 9 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.12. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Rand Rare independently H claim 9 , OH or C-Calkyl.15. The compound of claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , wherein Ris 5-6 membered heterocyclyl substituted by R; and Ris SORor SONRR.16. The ...

Methods and Compositions for Goss' Wilt Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.

POOL INCLUDING AQUEOUS SOLUTION OF POLYHEDRAL BORON HYDRIDE ANIONS OR CARBORANE ANIONS AND METHODS OF USING THE SAME

A method of storing nuclear fuel is described. In some cases, the method includes submerging at least a portion of a nuclear fuel rod in a storage pool containing an aqueous solution including at least one of polyhedral boron hydride anions or carborane anions. In some cases, the method includes adding a salt having a polyhedral boron hydride anion or carborane anion to a storage pool containing water and at least a portion of a nuclear fuel rod submerged in it. The method may include both of these. A storage pool is also described. The storage pool includes an aqueous solution having at least one of polyhedral boron hydride anions or carborane anions with at least a portion of a nuclear fuel rod submerged in the aqueous solution. A method of servicing a nuclear reactor core is also described. 1. A method of storing nuclear fuel outside of a nuclear reactor core , the method comprising at least one of:submerging at least a portion of a nuclear fuel rod in a storage pool comprising an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions; oradding a salt comprising a polyhedral boron hydride anion or carborane anion to a storage pool comprising water and at least a portion of a nuclear fuel rod submerged therein, wherein adding the salt provides an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions.2. A storage pool comprising:an aqueous solution comprising at least one of polyhedral boron hydride anions or carborane anions;and at least a portion of a nuclear fuel rod submerged in the aqueous solution.3. The method of claim 1 , wherein the nuclear fuel rod or the portion thereof is a spent fuel rod or a portion thereof or a used fuel rod or a portion thereof4. The method of claim 1 , wherein the nuclear fuel rod or the portion thereof is a fresh fuel rod or a portion thereof.5. A method of servicing a nuclear reactor core claim 1 , the method comprising receiving at least one used ...

APPARATUS AND A METHOD FOR DEPOSITION OF MATERIAL TO FORM A COATING

Apparatus and a method for creation and maintenance of a closed field system in which magnetrons and/or magnet assemblies are provided in a form to create a magnetic field around an area in which a substrate to be coated is located. The method also relates to the steps of cleaning the substrates and applying an adhesive layer prior to the material which is to form the coating. 1. A magnetron sputter ion plating apparatus comprising;a chamber with a top and a bottom, at least one substrate to be coated, said at least one substrate mounted on a holder located in the chamber and magnetic field means located in the chamber, the magnetic field means comprising at least two magnetrons and/or magnet assemblies each having an inner portion and an outer portion of opposite polarity, the magnetrons or magnet assemblies arranged as a closed field such that the outer portion of at least one of the magnetrons or magnet assemblies has a first polarity and an adjacent magnetron or magnet assembly has an outer portion with opposite polarity so that magnetic field lines extend between said magnetrons and/or magnet assemblies and substantially prevent the escape of electrons from the system between the magnetrons and/or magnet assemblies, at least two magnetrons with outer portions having opposing polarities are provided with targets of the same material and said at least two magnetrons are initially operated simultaneously for a period of time to perform a cleaning action and then apply a layer of material deposited from the said targets of the same material onto the said at least one substrate wherein the chamber is provided with side walls, a top and a bottom, the said at least two magnetrons and/or magnet assemblies are located at the side walls of the chamber and arranged around the holder on which the at least one substrate is located, which has a central position such that the magnetrons and/or magnet assemblies are substantially equally angularly spaced in a polygon or ring ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 2. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base.3. The method of claim 2 , wherein the base is diethylamine (DIEA).4. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours.5. The method of claim 1 , wherein the reaction is performed in the presence of a solvent.6. The method of claim 5 , wherein the solvent is 1 claim 5 ,2-dichloroethane (DCE):t-BuOH.7. The method of claim 6 , wherein the 1 claim 6 ,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol.8. The method of claim 1 , wherein the temperature is 80° C.9. The method of claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature.10. The method of claim 9 , wherein the temperature is 25° C.11. The method of claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc.12. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water.13. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO.14. The method of claim 9 , wherein isolating the compound of Formula (1) comprises filtration. This patent application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 60/912,597, filed Apr. 18, 2007.This invention relates to novel sulfonyl amide derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.It ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 2. The compound of wherein A is a phenyl.3. The compound of wherein A is a 5- to 6-membered heteroaryl.4. The compound of wherein each Ris independently selected from the group consisting of —H claim 1 , halo claim 1 , —CF claim 1 , —CN claim 1 , —NO claim 1 , —NRR claim 1 , —NRC(NRR)(═CR) claim 1 , —CR(NRR)(═NR) claim 1 , —NRC(NRR)(═NR) claim 1 , —NRC(O)R claim 1 , —C(O)NRR claim 1 , —C(O)R claim 1 , —C(O)C(O)R claim 1 , —C(O)OR claim 1 , —OC(O)R claim 1 , —OR claim 1 , —OC(O)OR claim 1 , —S(O)R claim 1 , and —S(O)(═NR)R.5. The compound of wherein each Ris independently selected from the group consisting of —H claim 1 , fluoro claim 1 , chloro claim 1 , —CF claim 1 , —CN claim 1 , —C(O)NRR claim 1 , and —OR.6. The compound of wherein Ris —C(O)NRR.7. The compound of wherein Rand Rare each independently selected from the group consisting —H and —(C-C)alkyl.8. The compound of wherein Ris —C(O)R.9. The compound of wherein Ris —C(O)Rand Ris selected from the group consisting of —NRR claim 8 , —(C-C)alkyl and —(C-C)cycloalkyl; wherein each of said —(C-C)alkyl claim 8 , and —(C-C)cycloalkyl of said Rgroup is optionally substituted by one to three Rgroups; and wherein two groups attached to the same tetravalent carbon atom of said —(C-C)alkyl and —(C-C)cycloalkyl of said Rmay optionally join to form a ring system selected from the group consisting of a —(C-C)cycloalkyl claim 8 , —(C-C)cycloalkenyl claim 8 , —(C-C)heterocycloalkyl claim 8 , and —(C-C)heterocycloalkenyl.10. The compound of wherein Ris —C(O)Rand Ris —NRR.11. The compound of wherein Ris —C(O)R claim 10 , Ris —NRR claim 10 , and Rand Rare each independently selected from the group consisting of —H and —(C-C)alkyl; and wherein said —(C-C)alkyl of said Rand Rgroups is optionally independently substituted with one to three groups selected from the group consisting of -halo claim 10 , —CF claim 10 , —CN claim 10 , —NO claim 10 , —OH claim 10 , —O((C-C) ...

Methods and Compositions for Gray Leaf Spot Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Gray Leaf Spot (GLS) resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NO:1-62, 64-70, 72-156, 158-172, 174-187, 189-377, 379, 380, 382-409, 411-459, 461-1233, 1360 and 1361, andb) selecting at least one corn plant comprising an allele of at least one of said markers associated with Gray Leaf Spot (GLS) resistance.2. The method according to claim 1 , wherein the at least one corn plant genotyped in step (a) and/or the at least one corn plant selected in step (b) is a corn plant from a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein genotyping is effected in step (a) by determining the allelic state of at least one of said corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back ...

An Aircraft for Aerial Delivery

An aircraft for the autonomous aerial delivery of a load to a target location, the aircraft comprising an airframe having at least one adjustable control structure for controlling the flight of the aircraft and a main body adapted to receive a load a self-contained control module releaseably connected to the airframe, the control module containing an actuator for adjusting the control structure and a controller for producing an electrical drive signal for controlling the actuator; and at least one linkage extending from the control module to the at least one adjustable control structure so as to operably connect the control module to the at least one adjustable control structure, wherein the actuator of the control module is adapted to adjust the at least one adjustable control structure using the at least one linkage so as to control the flight of the aircraft and to steer the aircraft to the target location.

Aerial Delivery Assembly

An aerial delivery assembly for autonomously delivering a load to a target location, the assembly comprising an airframe which comprises a main body, at least one deployable lift providing structure, the lift providing structure being moveable between a stowed position and a deployed position; and at least one deployable and adjustable control structure for controlling the flight of the assembly and moveable between a stowed position and a deployed position. The main body comprises a compartment for receiving a load to be delivered. The assembly further comprises a control unit comprising an actuation module for use in adjusting the control structure, wherein the control unit is releaseably connected to the airframe such that it is reusable in an aerial delivery assembly having a different airframe.

DUAL CONTACT PROCESS WITH SELECTIVE DEPOSITION

Embodiments disclosed herein include complementary metal-oxide-semiconductor (CMOS) devices and methods of making such devices. In an embodiment, a CMOS device comprises a first transistor with a first conductivity type, where the first transistor comprises a first source region and a first drain region, and a first interface material over the first source region and the first drain region. In an embodiment, the CMOS device further comprises a second transistor with a second conductivity type that is opposite form the first conductivity type, where the second transistor comprises a second source region and a second drain region, and a second interface material over the second source region and the second drain region. 1. A complementary metal-oxide-semiconductor (CMOS) device , comprising: a first source region and a first drain region; and', 'a first interface material over the first source region and the first drain region; and, 'a first transistor with a first conductivity type, wherein the first transistor comprises a second source region and a second drain region; and', 'a second interface material over the second source region and the second drain region., 'a second transistor with a second conductivity type that is opposite form the first conductivity type, wherein the second transistor comprises2. The CMOS device of claim 1 , wherein the first interface material comprises germanium claim 1 , and wherein the second interface material comprises TiSi.3. The CMOS device of claim 1 , wherein a first thickness of the first interface material is between approximately 1 nm and approximately 10 nm claim 1 , and wherein a second thickness of the second interface material is between approximately 1 nm and approximately 10 nm.4. The CMOS device of claim 3 , wherein the first thickness is substantially equal to the second thickness.5. The CMOS device of claim 1 , wherein the first conductivity type is P-type claim 1 , and wherein the second conductivity type is N-type.6. ...

DUAL CONTACT PROCESS WITH STACKED METAL LAYERS

Embodiments disclosed herein include complementary metal-oxide-semiconductor (CMOS) devices and methods of forming CMOS devices. In an embodiment, a CMOS device comprises a first transistor with a first conductivity type, where the first transistor comprises a first source region and a first drain region, and a first metal over the first source region and the first drain region. In an embodiment, the CMOS device further comprises a second transistor with a second conductivity type opposite form the first conductivity type, where the second transistor comprises a second source region and a second drain region, a second metal over the second source region and the second drain region, and the first metal over the second metal. 1. A complementary metal-oxide-semiconductor (CMOS) device , comprising:{'claim-text': ['a first source region and a first drain region; and', 'a first metal over the first source region and the first drain region; and'], '#text': 'a first transistor with a first conductivity type, wherein the first transistor comprises:'}{'claim-text': ['a second source region and a second drain region;', 'a second metal over the second source region and the second drain region; and', 'the first metal over the second metal.'], '#text': 'a second transistor with a second conductivity type opposite form the first conductivity type, wherein the second transistor comprises:'}2. The CMOS device of claim 1 , wherein the first metal comprises tungsten claim 1 , and wherein the second metal comprises one or more of titanium claim 1 , nickel claim 1 , cobalt claim 1 , and molybdenum.3. The CMOS device of claim 1 , wherein a thickness of the first metal is between approximately 1 nm and approximately 10 nm.4. The CMOS device of claim 1 , wherein the first conductivity type is P-type claim 1 , and wherein the second conductivity type is N-type.5. The CMOS device of claim 1 , wherein the first conductivity type is N-type claim 1 , and wherein the second conductivity type is ...

BLOOD COLLECTION DEVICES, SYSTEMS, AND METHODS

An access system can include a connector couplable with a catheter assembly having a catheter tube that can be positioned in a blood vessel of a patient. The access system can include a reinforcement member and a cannula couplable with a fluid collection device. The cannula can include a polymeric tube that defines a distal tip and a support tube that is stiffer than the polymeric tube and encompasses a portion of the polymeric tube. The support tube can define an inner diameter that is marginally larger than an outer diameter of the polymeric tube so as to prevent kinking of the portion of the polymeric tube that is encompassed by the support tube when the polymeric tube experiences proximally and distally directed compressive forces. 1. An access system comprising:a connector configured to couple with a catheter assembly that comprises a catheter tube configured to be positioned in a blood vessel of a patient;a reinforcement member fixedly secured to the connector, the reinforcement member being longitudinally elongated; and a polymeric tube that defines a distal tip; and', 'a support tube that is stiffer than the polymeric tube and encompasses a portion of the polymeric tube, the support tube defining an inner diameter that is marginally larger than an outer diameter of the polymeric tube so as to prevent kinking of the portion of the polymeric tube that is encompassed by the support tube when the polymeric tube experiences proximally and distally directed compressive forces, the support tube being in a fixed relationship with the polymeric tube so as to move in unison with the polymeric tube as the cannula is moved from the retracted position to the advanced position, the support tube defining a distal edge that encircles the polymeric tube and is proximally spaced from the distal tip of the polymeric tube, the distal edge of the support tube being positioned within the reinforcement member when the cannula is in the retracted position,, 'a cannula configured to ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 2. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base.3. The method of claim 2 , wherein the base is diethylamine (DIEA).4. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours.5. The method of claim 1 , wherein the reaction is performed in the presence of a solvent.6. The method of claim 5 , wherein the solvent is 1 claim 5 ,2-dichloroethane (DCE):t-BuOH.7. The method of claim 6 , wherein the 1 claim 6 ,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol.8. The method of claim 1 , wherein the temperature is 80° C.9. The method of claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature.10. The method of claim 9 , wherein the temperature is 25° C.11. The method of claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc.12. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water.13. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO.14. The method of claim 9 , wherein isolating the compound of Formula (1) comprises filtration. This patent application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 60/912,597, filed Apr. 18, 2007.This invention relates to novel sulfonyl amide derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.It ...

VERTICAL CAVITY SURFACE EMITTING DEVICE WITH A BURIED INDEX GUIDING CURRENT CONFINEMENT LAYER

A vertical cavity surface emitter device (e.g., VCSEL or RC-LED) containing a buried index-guiding current confinement aperture layer which is grown, and lithographically processed to define position, shape and dimension of an inner aperture. In a regrowth process, the aperture is filled with a single crystalline material from the third contact layer. The aperture provides for both current and optical confinement, while allowing for higher optical power output and improved thermal conductivity. 1. A vertical cavity surface emitting optoelectronic apparatus comprising:(a) a top reflector and bottom reflector;(b) a first contact layer above said bottom reflector and having a first type of doping;(c) an active region located above said first contact layer and containing one or more quantum well layers;(d) a second contact layer above said active region and having a second type of doping;(e) an index-guiding current confinement layer above said second contact layer, said index-guiding current confinement layer having a central aperture; and(f) a third contact layer, having a second type of doping, positioned over said index-guiding current confinement layer and filling the central aperture of said index-guiding current confinement layer.2. The apparatus of claim 1 , wherein said apparatus comprises a vertical-cavity surface-emitting laser (VCSEL) or a resonant-cavity light-emitting diode (RC-LED).3. The apparatus of claim 2 , wherein said vertical-cavity surface-emitting laser (VCSEL) or resonant-cavity light-emitting diode (RC-LED) claim 2 , comprises an electrically pumped device or an optically pumped device.4. The apparatus of claim 1 , wherein said one or more quantum well layers are sandwiched between cladding layers.5. The apparatus of claim 1 , further comprising electrodes comprising a bottom electrode and top electrode.6. The apparatus of claim 5 , wherein said bottom electrode is beneath a substrate which is beneath said bottom reflector.7. The apparatus of ...

CDK2/4/6 Inhibitors

This invention relates to compounds of general Formula (I) 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris F claim 1 , Cl claim 1 , C-Calkyl or C-Cfluoroalkyl claim 1 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare independently H claim 1 , OH or C-Calkyl.6. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.7. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris F claim 5 , Cl claim 5 , C-Calkyl or C-Cfluoroalkyl claim 5 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.8. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Rand Rare independently H claim 5 , OH or C-Calkyl.10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Ris 3-10 membered heterocyclyl substituted by Rand optionally further substituted by one or more R; and Ris SORor SONRR.11. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Ris F claim 9 , Cl claim 9 , C-Calkyl or C-Cfluoroalkyl claim 9 , where said C-Calkyl and C-Cfluoroalkyl are optionally substituted by OH.12. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein Rand Rare independently H claim 9 , OH or C-Calkyl.15. The compound of claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , wherein Ris 5-6 membered heterocyclyl substituted by R; and Ris SORor SONRR.16. The ...

TISSUE ENGAGEMENT DEVICES, SYSTEMS, AND METHODS

Tissue engagement devices can include a sheath, a first arm, a second arm and an actuation cannula. At least a proximal portion of each arm is within the sheath. The actuation cannula is also within the sheath, and can move within the sheath between a retracted position and an extended position. The actuation cannula moves at least a portion of each of the first and second arms into a region between an exterior surface of the actuation cannula and an interior surface of the sheath as the actuation cannula moves to the extended position. 1. A tissue engagement device comprising:a sheath;a first arm of which at least a proximal portion thereof is within the sheath, the first arm comprising a first piercing surface;a second arm of which at least a proximal portion thereof is within the sheath, the second arm comprising a second piercing surface; andan actuation cannula within the sheath, the actuation cannula being configured to move within the sheath between a retracted position and an extended position, wherein the actuation cannula moves at least a portion of each of the first and second arms into a region between an exterior surface of the actuation cannula and an interior surface of the sheath as the actuation cannula moves distally to the extended position.2. The tissue engagement device of claim 1 , wherein the first and second arms extend distally from a distal end of a cannular base claim 1 , and wherein at least a portion of the cannular base is positioned between the exterior surface of the actuation cannula and the interior surface of the sheath.3. (canceled)4. The tissue engagement device of claim 2 , wherein the first and second arms and the cannular base are integrally formed from a unitary piece of material.5. (canceled)6. The tissue engagement device of claim 2 , wherein claim 2 , when the actuation cannula is in the retracted position claim 2 , the first arm crosses the second arm at a position within the sheath that is distal to the distal end of the ...

New pepper plants and fruits with improved nutritional value

The present invention concerns Capsicum annuum plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles.

FEMORAL CUT GUIDE

The present disclosure provides a femoral cut guide for preparing a distal femur to receive a prosthetic femoral component of a knee implant. The prosthetic femoral component includes a central box. The femoral cut guide replicates the size and shape of the prosthetic femoral component, such that the femoral cut guide may serve as a trial or provisional component used to reduce and test the prepared knee joint before implanting the final prosthetic femoral component. The femoral cut guide includes a detachable box cut guide for preparing the distal femur to receive the central box of the prosthetic femoral component. 116-. (canceled)17. A femoral cut guide for preparing a distal femur to receive a prosthetic femoral component , the prosthetic femoral component including a first articulating surface and an opposing first bone-contacting surface that rests against the distal femur , the prosthetic femoral component further including a box that projects proximally from the first bone-contacting surface , the femoral cut guide comprising:a body having a second articulating surface that is shaped to replicate the first articulating surface and a second bone-contacting surface that is shaped to replicate the first bone-contacting surface, the body including a medial side and a lateral side that define an opening therebetween;a box cut guide removably coupled to the body such that the box cut guide spans the medial and lateral sides of the body across the opening, the box cut guide including a first reference surface located in a first cut plane; anda second cut guide removably coupled to the body at a different location than the box cut guide such that the second cut guide spans the medial and lateral sides of the body across the opening, the second cut guide including a second reference surface that is located in a second cut plane, the second cut plane intersecting the first cut plane at an obtuse angle.18. The femoral cut guide of claim 17 , wherein the box cut guide ...

Coated substrate

The invention to which this application relates is improvements to the provision of Molybdenum and/or Tungsten containing coatings of the type which can be used to improve certain characteristics of the surface of a substrate to which the coating is applied. In one embodiment the coating also includes Ti to provide the advantages of high adhesion, high humidity and wear resistance of the coating and TiB 2 to promote the formation of a relatively uniform, dense, coating, so strengthening the coating which is formed and improving the high temperature performance of the coatings.

BLOOD COLLECTION DEVICES, SYSTEMS, AND METHODS

In certain instances, an access system can include a connector to couple with a catheter assembly, a reinforcement member fixedly secured to the connector, and a cannula movable relative to the reinforcement member. The cannula can include a polymeric tube and a support tube that encompasses a portion of and is stiffer than the polymeric tube. The support tube can define an inner diameter that is marginally larger than an outer diameter of the polymeric tube to prevent kinking of the polymeric tube and can be in a fixed relationship with the polymeric tube. A distal edge of the support tube is proximally spaced from a distal tip of the polymeric tube and is within the reinforcement member when the distal tip of the polymeric tube is first positioned distal of and external to the reinforcement member as the cannula is advanced. 1. An access system comprising:a connector configured to couple with a catheter assembly that comprises a catheter tube configured to be positioned in a blood vessel of a patient;a reinforcement member fixedly secured to the connector; and a polymeric tube that defines a distal tip; and', 'a support tube that encompasses a portion of and is stiffer than the polymeric tube, the support tube defining an inner diameter that is marginally larger than an outer diameter of the polymeric tube so as to prevent kinking of the polymeric tube, the support tube being in a fixed relationship with the polymeric tube so as to move in unison therewith, the support tube defining a distal edge that is proximally spaced from the distal tip of the polymeric tube and that is configured to be within the reinforcement member when the distal tip of the polymeric tube is first positioned distal of and external to the reinforcement member as the cannula is transitioned from the retracted position to the advanced position,, 'a cannula movable relative to the reinforcement member from a retracted position in which at least a portion of the cannula is within the ...

LOW-LATENCY INTERACTIVE MULTIVIEWER INTERFACES AND METHODS FOR VIDEO BROADCAST EQUIPMENT

Low-latency interactive multiviewer interfaces and methods for video broadcast equipment are disclosed. A video switcher includes an integrated multiviewer to generate a multiviewer interface. Video signals are received from video sources and a user interface graphic is received from an external source such as an external computer. The received video signals are routed in a video path of the video switcher to be presented in a multiviewer interface on a display, and the received interface graphic is overlaid on the received video signals for presentation in the multiviewer interface. Realtime elements associated with frames of the video signals may also be generated within the video switcher and combined with the video signals and the externally generated interface graphic in the multiviewer interface. The video signals could include video signals from external video sources, outputs of internal processing elements within the video switcher, and/or intermediary video signals within the video switcher. 1. A video switcher comprising:an input to receive video signals from video sources and a user interface graphic from an external source;a video path for the received video signals from the video sources to be presented in a multiviewer interface on a display;an overlay module to overlay the received interface graphic on the received video signals for presentation in the multiviewer interface.2. The video switcher of claim 1 , the video signals comprising one or more of: video signals from external video sources claim 1 , outputs of internal processing elements within the video switcher claim 1 , and intermediary video signals within the video switcher.3. The video switcher of claim 1 , the interface graphic comprising graphics representing a graphical user interface.4. The video switcher of claim 3 , the graphical user interface comprising graphical control elements to trigger commands to one or more of: the video switcher and external equipment.5. The video switcher ...

Methods and Compositions for Goss' Wilt Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.

FEMORAL CUT GUIDE

The present disclosure provides a femoral cut guide for preparing a distal femur to receive a prosthetic femoral component of a knee implant. The prosthetic femoral component includes a central box. The femoral cut guide replicates the size and shape of the prosthetic femoral component, such that the femoral cut guide may serve as a trial or provisional component used to reduce and test the prepared knee joint before implanting the final prosthetic femoral component. The femoral cut guide includes a detachable box cut guide for preparing the distal femur to receive the central box of the prosthetic femoral component. 1. A method of preparing a distal femur to receive a prosthetic femoral component , the prosthetic femoral component including a first articulating surface , an opposing first bone-contacting surface , and a box that projects proximally from the first bone-contacting surface to a top surface , the method comprising the steps of:providing a body having a second articulating surface that is shaped to replicate the first articulating surface and a second bone-contacting surface that is shaped to replicate the first bone-contacting surface;positioning the second bone-contacting surface of the body against the distal femur;attaching a box cut guide to the body, the box cut guide including a reference surface located in a cut plane;guiding a cutting tool across the reference surface of the box cut guide to prepare a resected surface of the distal femur, the resected surface of the distal femur located in the cut plane;removing the body from the distal femur; andpositioning the first bone-contacting surface of the prosthetic femoral component against the distal femur with the top surface of the box bordering the resected surface of the distal femur.2. The method of claim 1 , wherein the reference surface of the box cut guide defines a guide slot claim 1 , the guiding step comprising guiding the cutting tool through the guide slot.3. The method of claim 1 , ...

Methods and Compositions for Gray Leaf Spot Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Gray Leaf Spot (GLS) resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NO:1-62, 64-70, 72-156, 158-172, 174-187, 189-377, 379, 380, 382-409, 411-459, 461-1233, 1360 and 1361, andb) selecting at least one corn plant comprising an allele of at least one of said markers associated with Gray Leaf Spot (GLS) resistance.2. The method according to claim 1 , wherein the at least one corn plant genotyped in step (a) and/or the at least one corn plant selected in step (b) is a corn plant from a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein genotyping is effected in step (a) by determining the allelic state of at least one of said corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back ...

BIDIRECTIONAL MEDICAL VALVES

A medical valve can include a housing that includes a sidewall and defines a chamber. The medical valve can include a septum coupled to the housing. The septum can include a proximal surface and a selectively openable closure positioned within the chamber. The medical valve can further include a plurality of projections that extend away from the sidewall and are configured to contact the proximal surface of the septum to oppose movement of a restricted portion of the septum in a proximal direction such that an aspiration cracking pressure required to open the closure to permit fluid flow through the septum in the proximal direction exceeds an infusion cracking pressure required to open the closure to permit fluid flow through the septum in the distal direction. 1. A medical valve comprising:a housing comprising a sidewall and defining a chamber;a connection interface in fluid communication with the chamber, the connection interface being configured to couple with one or more medical devices for infusion of fluid through the medical valve in a distal direction and aspiration of fluid through the medical valve in a proximal direction;a septum coupled to the housing, the septum comprising a proximal surface, a distal surface, and a selectively openable closure that extends through a full thickness of the septum between the proximal surface and the distal surface, wherein the closure is positioned within the chamber; anda plurality of projections that extend away from the sidewall and are configured to contact the proximal surface of the septum to oppose movement of a restricted portion of the septum in the proximal direction such that an aspiration cracking pressure required to open the closure to permit fluid flow through the septum in the proximal direction exceeds an infusion cracking pressure required to open the closure to permit fluid flow through the septum in the distal direction.2. The medical valve of claim 1 , wherein the plurality of projections are ...

CDK2 INHIBITORS

This invention relates to compounds of Formula (I) 3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris -L-(5-10 membered heteroaryl) claim 2 , where said 5-10 membered heteroaryl is optionally substituted by one or more R.4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein said 5-10 membered heteroaryl is pyrazolyl or isoxazolyl claim 3 , optionally substituted by one or more R.5. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein Lis a bond or methylene.6. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein each Ris independently C-Calkyl or C-Calkoxy claim 2 , where each C-Calkyl is optionally substituted by one or more R.7. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris H and Ris C-Calkyl.8. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris H and Ris -L-(C-Ccycloalkyl) claim 2 , where said C-Ccycloalkyl is optionally substituted by one or more R.9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof claim 8 , wherein Lis a bond or methylene.10. A compound selected from the group consisting of:(1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl propan-2-ylcarbamate; and(1R,3S)-3-(3-{[(3-methyl-1,2-oxazol-5-yl)acetyl]amino}-1H-pyrazol-5-yl)cyclopentyl (1-methylcyclopropyl)carbamate;or a pharmaceutically acceptable salt thereof.13. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier or excipient.14. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , and a pharmaceutically acceptable carrier or excipient.15. A pharmaceutical composition comprising a compound of claim 11 , ...

HIGH SURFACE AREAS (HSA) COATINGS AND METHODS FOR FORMING THE SAME

The invention relates to a method of applying a coating to an article and an article with said coating. The coating is provided with at least one layer which has a surface area which is greater than the apparent or projected area of the said layer of the coating. This high surface area coating is applied in relatively high gas pressures and in one embodiment can be applied using a magnetron sputter ion plating system. 1: An article with a coating applied to at least a portion of the same , said coating including at least one layer which has a surface area which is greater than the apparent or projected area of the said layer of the coating.2: An article according to wherein the said surface area is at least 30 times greater than the said apparent or projected area.3: An article according to wherein the apparent or projected area of the said at least one layer is defined as the area of an equivalent homogeneous coating claim 1 , fully conformal with the surface of the article.45-. (canceled)6: An article according to wherein the said at least one layer is provided within the coating with at least one further layer of material applied over the same.7: An article according to wherein the coating has a grain size in the range of 3 to 100 nm.8: An article according to wherein the coating has a layer thickness in the range of 50 nm to 10 μm.910-. (canceled)11: An article according to wherein the coating is composed of any claim 1 , or any combination claim 1 , of metal claim 1 , semi-metals claim 1 , and/or ceramics.12: An article according to wherein the coating is applied to the article to enable and/or improve the use of the article for any claim 1 , or any combination of catalytic claim 1 , photo-catalytic claim 1 , anti-reflection claim 1 , antibacterial claim 1 , sensors claim 1 , filters claim 1 , pyrophoric devices claim 1 , hydrophobic surfaces claim 1 , biomedical prostheses and/or thermal barrier functions.13: An article according to wherein the said at least ...

Pepper Plants Producing Fruits With Extreme Dark Green Color

The present invention concerns plants producing pepper fruits exhibiting new physicochemical characteristics of the pepper fruit in relation to pigments such as chlorophyll A, chlorophyll B, α-carotene, β-carotene, lutein and/or violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles. The invention further provides novel pepper cultivars RPP 25822, RPP 26098, RPP 26105, 16452A, 16452B 16452C and 8728C, and plant parts, seed, and tissue culture therefrom. The invention additionally provides methods for producing a pepper plant by crossing the pepper plants of the invention with themselves or another pepper plant. The invention also provides pepper plants produced from such a crossing as well as plant parts, seed, and tissue culture therefrom. 1. A seed of pepper cultivar RPP 25822 , RPP 26098 , RPP 26105 , 8728C , 16452A , 16452B or 16452C , a representative sample of seed having been deposited under ATCC Accession Nos. PTA-121983 , PTA-121984 , PTA-121982 , PTA-121980 , PTA-121981 and PTA-121985 , respectively , or pepper cultivar 8728C , a representative sample of seed having been deposited under NCIMB Accession Number 41858.2. A plant of pepper cultivar RPP 25822 , RPP 26098 , RPP 26105 , 16452A , 16452B or 16452C , a representative sample of seed having been deposited under ATCC Accession Nos. PTA-121983 , PTA-121984 , PTA-121982 , PTA-121980 , PTA-121981 and PTA-121985 , respectively , or pepper cultivar 8728C , a representative sample of seed having been deposited under NCIMB Accession Number 41858.3. A pepper plant claim 2 , or a part thereof claim 2 , having all the physiological and morphological characteristics of the pepper plant of .4. A plant that shares at least 50% ...

TISSUE ENGAGEMENT DEVICES, SYSTEMS, AND METHODS

A method can include engaging the pericardium of a patient at two engagement positions of the pericardium. The method can further include moving the two engagement positions of the pericardium away from each other to tension a portion of the pericardium. The method can further include advancing an access device through the tensioned portion of the pericardium to introduce the access device into the pericardial space of the patient. Other and further methods are also disclosed. 1. A method comprising:engaging the pericardium of a patient with first and second arms of a tissue engagement device;tensioning a portion of the pericardium by separating at least a portion of each of the first and second arms from each other while the first and second arms continue to engage the pericardium; andafter said tensioning, advancing an access device through the tensioned portion of the pericardium to introduce the access device into the pericardial space of the patient.2. A method comprising:engaging the pericardium of a patient at two engagement positions of the pericardium;moving the two engagement positions of the pericardium away from each other to tension a portion of the pericardium; andadvancing an access device through the tensioned portion of the pericardium to introduce the access device into the pericardial space of the patient. This application is a continuation of U.S. patent application Ser. No. 15/361,312, titled TISSUE ENGAGMENT DEVICES, SYSTEMS, AND METHODS, which claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 62/260,212, titled TISSUE ENGAGEMENT DEVICES, SYSTEM, AND RELATED METHODS, filed on Nov. 25, 2015; the entire contents of each of the foregoing applications are hereby incorporated by reference herein.The present disclosure relates generally to systems, devices and methods for providing access to a region beneath a tissue layer. More specifically, the present disclosure relates to devices and methods for accessing the ...

CDK2 INHIBITORS

This invention relates to compounds of Formula (I) 3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris -L-(5-10 membered heteroaryl) claim 2 , where said 5-10 membered heteroaryl is optionally substituted by one or more R.4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein said 5-10 membered heteroaryl is pyrazolyl or isoxazolyl claim 3 , optionally substituted by one or more R.5. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein Lis a bond or methylene.6. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein each Ris independently C-Calkyl or C-Calkoxy claim 2 , where each C-Calkyl is optionally substituted by one or more R.7. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris H and Ris C-Calkyl.8. The compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris H and Ris -L-(C-Ccycloalkyl) claim 2 , where said C-Ccycloalkyl is optionally substituted by one or more R.9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof claim 8 , wherein Lis a bond or methylene.10. A compound selected from the group consisting of:(1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl propan-2-ylcarbamate; and(1R,3S)-3-(3-{[(3-methyl-1,2-oxazol-5-yl)acetyl]amino}-1H-pyrazol-5-yl)cyclopentyl (1-methylcyclopropyl)carbamate.13. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier or excipient.14. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , and a pharmaceutically acceptable carrier or excipient.15. A pharmaceutical composition comprising a compound of claim 11 , and a pharmaceutically acceptable carrier or ...

METHODS OF ORDERING AND MANUFACTURING ORTHOPEDIC COMPONENTS

Methods of ordering and manufacturing orthopedic components eliminate the need to stockpile and inventory large volumes of implants and instruments. In one exemplary embodiment, the surgeon begins by acquiring anatomical data from a patient. The anatomical data may then be loaded into a data comparison program. The data comparison program performs a best-fit analysis by comparing the patient's anatomical data to a number of predesigned, tested, and validated virtual implant models that are stored in a database. Once an implant has been identified by the data comparison program for the individual patient, the surgeon may place an order electronically with the manufacturer via the internet. In one exemplary embodiment, when placing the order, the surgeon will specify the type of implant, the surgery date, specific patient information, shipping information, and the preferred surgical technique that the surgeon anticipates using. 1. A method of ordering and manufacturing an implant and related instruments , comprising the steps of:receiving anatomical data collected from a patient;comparing the anatomical data to a database of implant designs;identifying an implant design from the implant designs in the database based on a result of said step of comparing the anatomical data to a database of implant designs;manufacturing an implant based on the identified implant design;manufacturing at least one instrument for use in implanting the implant;packaging the implant and the instrument in at least one container;contemporaneously shipping the implant and the instrument in the at least one container to a customer, andreceiving the at least one container after the at least one instrument has been used.2. The method of claim 1 , wherein the instrument involved in said steps of packaging the implant and instrument and contemporaneously shipping the implant and instrument is an unused instrument.3. The method of claim 1 , wherein said step of packaging the implant and the at least ...

Methods and Compositions for Goss' Wilt Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Goss' Wilt resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NOs: 13, 19, 24, 27, 36, 50, 53, 90, 94, 95, 97, 99, 101, 102, 106, 110, 111, 119, 121, 122, 124, 128, 130-132, 136, 138, 141, 146, 153, 158-160, 162, 164, 166, 169, 172, 175, 177, 186, 200, 202, 203, 207, 208, 215, 216, 218, 220, 224, 228, 231-236, 244, 248, 250, 252, 256, 257, 260, 265-267, 271-274, 278, 279, 282, 287, 289, 294-296, 299, 317, 320, 332-334, 337, 347, 355, 362, 363, 366-368, 370, 371, 375, 381, 382, 392, 395, 401, 408, 409, 411, 412, 422, 423, 429, 430, 433, 438, 440, 447, 474, 476, 479, 480, 482, 486, 490, 493, 498, 500, 525, 530, 533, 556, 566, 582, 585, 587, 589, 593, 594, 599, 611, 618, 621, 623, 629, 630, 632, 637, 639, 646, 649, 650, 657, 665, 669, 678, 679, 688, 690, 704, 709, 710, 717, 719-721, 726, 727, 733, 734, 744, 746, 758, 760, 764, 768, 773, 792, 793, 812, 821, 825, 835, 844, 846, 850, 854, 856-858, 874, 876, 880, 882, 885, 893, 896, 897, 915, 926, 940, 942, 949, 951, 957, 963, 964, 974, 976, 981, 983, 990, 997, 999, 1000, 1015, 1016, 1027, 1043, 1049, 1053, 1054, 1056, 1075, 1081, 1087, 1088, 1098-1100, 1104, 1105, 1108, 1110, 1115, 1122, 1131, 1133, 1142, 1143, 1145, 1146, 1148, 1149, 1159, 1168, 1174, 1184, 1186, 1196, 1204, 1212, 1215, 1229, 1234-1302, and 1303, andb) selecting at least one corn plant comprising an allele of at least one of said markers that is ...

AIR-CAVITY DOMINANT VERTICAL CAVITY SURFACE EMITTING LASERS

Vertical-cavity surface-emitting laser (VCSEL) structures are described which enable their use as widely wavelength-swept coherent light sources and multiple-wavelength VCSEL arrays. Three general configurations are described: (a) a semiconductor-cavity-dominant (SCD) with high reflection at the semiconductor-air interface, (b) an extended-cavity (EC) design in which reflections at the semiconductor-air interface is reduced to insignificance compared to the SCD design with a refractive index-matched layer (i.e., AR layer) so the entire structure resonates as one cavity, and (c) an air-cavity-dominant (ACD) design which facilitates a larger field confinement in the air gap, and the increased field confinement causes the air gap to be the dominant cavity. 1. An air-cavity-dominant (ACD) vertical-cavity surface-emitting laser (VCSEL) apparatus , comprising:a top mirror and a semiconductor portion beneath said top mirror and separated from said top mirror by an air-gap; andsaid semiconductor portion comprising a semiconductor-air coupling (SAC) region, a top distributed Bragg reflector (DBR) beneath said semiconductor-air coupling (SAC) region, a semiconductor cavity containing an active region beneath the top DBR, a bottom DBR beneath said semiconductor cavity, and a substrate beneath said bottom DBR;wherein said SAC region comprises a window layer (WL) followed by a quarter-lambda low-refractive index layer.2. The apparatus of claim 1 , wherein said window layer (WL) has a thickness of zero.3. The apparatus of claim 1 , wherein said window layer (WL) has a thickness which is a positive integer multiple of half-lambda.4. The apparatus of claim 1 , wherein for a one-lambda high-refractive index semiconductor cavity claim 1 , said top DBR comprises integer pairs of low-refractive index and high-refractive index quarter-lambda layers claim 1 , starting with a low-refractive index layer above said semiconductor cavity claim 1 , and finishing with a high-refractive index ...

Methods and Compositions for Goss' Wilt Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Goss' Wilt resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NOs: 13, 19, 24, 27, 36, 50, 53, 90, 94, 95, 97, 99, 101, 102, 106, 110, 111, 119, 121, 122, 124, 128, 130-132, 136, 138, 141, 146, 153, 158-160, 162, 164, 166, 169, 172, 175, 177, 186, 200, 202, 203, 207, 208, 215, 216, 218, 220, 224, 228, 231-236, 244, 248, 250, 252, 256, 257, 260, 265-267, 271-274, 278, 279, 282, 287, 289, 294-296, 299, 317, 320, 332-334, 337, 347, 355, 362, 363, 366-368, 370, 371, 375, 381, 382, 392, 395, 401, 408, 409, 411, 412, 422, 423, 429, 430, 433, 438, 440, 447, 474, 476, 479, 480, 482, 486, 490, 493, 498, 500, 525, 530, 533, 556, 566, 582, 585, 587, 589, 593, 594, 599, 611, 618, 621, 623, 629, 630, 632, 637, 639, 646, 649, 650, 657, 665, 669, 678, 679, 688, 690, 704, 709, 710, 717, 719-721, 726, 727, 733, 734, 744, 746, 758, 760, 764, 768, 773, 792, 793, 812, 821, 825, 835, 844, 846, 850, 854, 856-858, 874, 876, 880, 882, 885, 893, 896, 897, 915, 926, 940, 942, 949, 951, 957, 963, 964, 974, 976, 981, 983, 990, 997, 999, 1000, 1015, 1016, 1027, 1043, 1049, 1053, 1054, 1056, 1075, 1081, 1087, 1088, 1098-1100, 1104, 1105, 1108, 1110, 1115, 1122, 1131, 1133, 1142, 1143, 1145, 1146, 1148, 1149, 1159, 1168, 1174, 1184, 1186, 1196, 1204, 1212, 1215, 1229, 1234-1302, and 1303, andb) selecting at least one corn plant comprising an allele of at least one of said markers that is ...

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I 2. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base.3. The method of claim 2 , wherein the base is diethylamine (DIEA).4. The method of claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours.5. The method of claim 1 , wherein the reaction is performed in the presence of a solvent.6. The method of claim 5 , wherein the solvent is 1 claim 5 ,2-dichloroethane (DCE):t-BuOH.7. The method of claim 6 , wherein the 1 claim 6 ,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol.8. The method of claim 1 , wherein the temperature is 80° C.9. The method of claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature.10. The method of claim 9 , wherein the temperature is 25° C.11. The method of claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc.12. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water.13. The method of claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO.14. The method of claim 9 , wherein isolating the compound of Formula (1) comprises filtration. This patent application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 60/912,597, filed Apr. 18, 2007.This invention relates to novel sulfonyl amide derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.It ...

Methods and Compositions for Gray Leaf Spot Resistance in Corn

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with spp. 1. A method of identifying a corn plant comprising at least one allele associated with Gray Leaf Spot (GLS) resistance allele in a corn plant comprising:a) genotyping at least one corn plant with at least one nucleic acid marker selected from the group consisting of SEQ ID NO:1-62, 64-70, 72-156, 158-172, 174-187, 189-377, 379, 380, 382-409, 411-459, 461-1233, 1360 and 1361, andb) selecting at least one corn plant comprising an allele of at least one of said markers associated with Gray Leaf Spot (GLS) resistance.2. The method according to claim 1 , wherein the at least one corn plant genotyped in step (a) and/or the at least one corn plant selected in step (b) is a corn plant from a population generated by a cross.3. The method of claim 2 , wherein said cross is effected by mechanical emasculation claim 2 , chemical sterilization claim 2 , or genetic sterilization of a pollen acceptor.4. The method of claim 1 , wherein genotyping is effected in step (a) by determining the allelic state of at least one of said corn genomic DNA markers.5. The method according to claim 1 , wherein the selected one or more corn plants exhibit at least partial resistance to a GLS-inducing fungus or at least substantial resistance to a GLS-inducing fungus.6. The method of claim 2 , wherein said population is generated by a cross of at least one Gray Leaf Spot (GLS) resistant corn plant with at least one Gray Leaf Spot (GLS) sensitive corn plant.7. The method of claim 2 , wherein said population is a segregating population.8. The method of claim 2 , wherein said cross is a back ...

Catheter delivery devices, systems, and methods

A system can include a handle and a needle fixedly secured to the handle. The needle can include a distal tip that can be inserted through a sidewall of a vessel of a patient. The system can further include a catheter that defines a lumen through which the needle extends and includes an engagement surface at an interior thereof. A cannular stiffener can be positioned within the lumen of the catheter at an exterior of the needle and can include an engagement surface that can press distally on the engagement surface of the catheter to advance the catheter distally over the needle and through a lumen of the vessel when the stiffener is advanced distally over the needle. The system can further include a stiffener hub attached to the stiffener, the stiffener hub being movably coupled with the handle so as to translate relative thereto. The stiffener hub can be configured to move distally relative to the handle from a retracted position to a deployed position to advance the stiffener and the catheter over the needle and to a target depth within the lumen of the vessel as the handle is held stationary relative to the vessel.

ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH

This invention relates to compounds of general Formula I 5. The compound of claim 4 , or a pharmaceutically acceptable salt thereof claim 4 , wherein:A is CH or N;{'sup': 3', '5, 'Ris 5- to 7-membered heterocyclyl optionally substituted with 1 R; and'}{'sup': '5', 'sub': 1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2, 'Ris selected from the group consisting of F, OH, —CN, C-Calkyl, C-Cfluoroalkyl, C-Calkoxy, C-Cfluoroalkoxy, C-Calkoxy-C-Calkyl-, C-Cfluoroalkoxy-C-Calkyl-, C-Calkoxy-C-Cfluoroalkyl-, and C-Cfluoroalkoxy-C-Cfluoroalkyl-.'}6. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris selected from the group consisting of 2-azaspiro[3.3]heptanyl claim 5 , tetrahydrofuranyl claim 5 , pyrrolidinyl claim 5 , and piperidinyl claim 5 , wherein each of the heterocyclyl selections is optionally substituted with 1 R; and Ris selected from the group consisting of F claim 5 , OH claim 5 , —CN claim 5 , C-Calkyl claim 5 , C-Cfluoroalkyl claim 5 , C-Calkoxy claim 5 , C-Cfluoroalkoxy claim 5 , C-Calkoxy-C-Calkyl- claim 5 , C-Cfluoroalkoxy-C-Calkyl- claim 5 , C-Calkoxy-C-Cfluoroalkyl- claim 5 , and C-Cfluoroalkoxy-C-Cfluoroalkyl-.7. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris 2-azaspiro[3.3]heptan-6-yl optionally substituted with 1 Rthat is selected from the group consisting of C-Calkyl claim 5 , C-Cfluoroalkyl claim 5 , C-Calkoxy-C-Calkyl- claim 5 , and C-Cfluoroalkoxy-C-Calkyl-.8. The compound of claim 4 , or a pharmaceutically acceptable salt thereof claim 4 , wherein:A is CH or N;{'sup': 3', '5', '6, 'sub': 3', '6', '2, 'Ris C-Ccycloalkyl optionally substituted with 1 or 2 Rand further optionally substituted with 1 —N(R);'}{'sup': '5', 'sub': 1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2', '1', '2, 'each Ris independently selected from the group ...

CDK2/4/6 Inhibitors

This invention relates to compounds of general Formula (1) 2. The method of claim 1 , wherein the cancer is (a) breast cancer or ovarian cancer; (b) characterized by amplification or overexpression of cyclin E1 (CCNE1) or cyclin E2 (CCNE2); or (c) both (a) and (b).4. The method of claim 3 , wherein the cancer is selected from the group consisting of breast cancer claim 3 , ovarian cancer claim 3 , bladder cancer claim 3 , uterine cancer claim 3 , prostate cancer claim 3 , lung cancer claim 3 , esophageal cancer claim 3 , head and neck cancer claim 3 , colorectal cancer claim 3 , kidney cancer claim 3 , liver cancer claim 3 , pancreatic cancer claim 3 , stomach cancer and thyroid cancer.5. The method of claim 4 , wherein the cancer is breast cancer.6. The method of claim 5 , wherein the breast cancer is hormone receptor positive (HR+) claim 5 , human epidermal growth factor receptor 2 negative (HER2−) breast cancer.7. The method of claim 6 , wherein the breast cancer is HR+ claim 6 , HER2− advanced or metastatic breast cancer.8. The method of claim 5 , wherein the breast cancer is triple negative breast cancer (TNBC).9. The method of claim 8 , wherein the breast cancer is advanced or metastatic TNBC.10. The method of claim 4 , wherein the cancer is ovarian cancer.11. The method of claim 4 , wherein the cancer is characterized by amplification or overexpression of CCNE1 and/or CCNE2.12. The method of claim 3 , wherein the subject is human.13. The method of claim 3 , further comprising administering to the subject an amount of an additional anticancer therapeutic agent claim 3 , which amounts are together effective in treating said cancer. The present application is a divisional application of U.S. patent application Ser. No. 16/251,032, filed Jan. 17, 2019, now allowed, which is a continuation of U.S. patent application Ser. No. 15/664,265, filed Jul. 31, 2017, now U.S. Pat. No. 10,233,188, which claims the benefit of priority to U.S. Provisional Application No. 62/ ...

Two-piece radio-transparent proximal targeting device for a locking intramedullary nail

The targeting device of this invention includes a radio-transparent handle and a metal snap fit barrel. The radio-transparent handle reduces obstructions in the radio-graphic image to provide a clearer image to the surgeon for proper placement of the locking screws. The metal snap fit barrel is retained in the handle by an interference fit between the handle and biased keys carried by the barrel. After use, the barrel may be easily disassembled for cleaning by striking a removal tool against the keys to drive the barrel from the handle.

Ratchet lock for an intramedullary nail locking bolt

This invention includes a ratchet wheel carried by the locking bolt and engaged by a pin carried by the targeting guide. The pin and ratchet wheel permit the locking bolt to rotate in a tightening direction and prevent the bolt from rotating in a direction to cause the bolt to loosen. Therefore, during impact, the bolt is prevented from loosening. After the IM rod is inserted and the surgeon wants to remove the targeting guide, the pin is shifted and locked into a disengaged position with the ratchet wheel to permit the locking bolt to rotate without obstruction. The ratchet pin may be locked in its retracted position.

Thienyl-containing glycopyranosyl derivatives as antidiabetics

Sulfonyl amide derivatives for the treatment of abnormal cell growth

The present invention relates to a compound of the formula (I) wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

sulfonyl amide derivatives for the treatment of abnormal cell growth, their sos, as well as pharmaceutical composition

derivados de sulfonil amida para o tratamento de crescimento celular anormal, seu usos, bem como composição farmacêutica. a presente invenção se refere a um composto da fórmula i na qual r1 a r6, a, b, n e m são definidos aqui. tais novos derivados de sulfonil amida são úteis no tratamento de crescimento celular anormal, tal como câncer, em mamíferos. esta invenção também refere-se a uma método de usar tais compostos no tratamento de crescimento celular anormal em mamíferos, especialmente seres humanos, e às composições farmacêuticas contendo tais compostos. sulfonyl amide derivatives for the treatment of abnormal cell growth, their uses, as well as pharmaceutical composition. The present invention relates to a compound of formula I in which r1 to r6, a, b, n and m are defined herein. such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. this invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Anti-proliferative agents for treating PAH

This invention relates to compounds of general Formula I in which A, R

PYRID [2,3-d] PYRIMIDIN-7 (8H) -ONAS 6-FLUOROALKYL-2- (ALKYLSULFONYLPIPERIDIN-4-IL) AMINO SUBSTITUTES

<p>Esta invención se relaciona con compuestos de tipo 5 pirido[2,3-d]pirimidin-7(8h)-onas 6-fluoroalquil-2-(alquilsulfonilpiperidin-4-il)amino sustituidas, de la fórmula general (I)</p> <p>ESPACIO PARA FÓRMULA</p> <p>y sales farmacéuticamente aceptables de los mismos, en los cuales R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q y r son como se definen en la presente, a composiciones farmacéuticas que comprenden tales compuestos y sales, y métodos para utilizar tales compuestos, sales y composiciones para el tratamiento de crecimiento celular anormal, incluyendo cáncer.</p> <p> </p> <p> This invention relates to 5-pyrido [2,3-d] pyrimidin-7 (8h) -ones 6-fluoroalkyl-2- (alkylsulfonylpiperidin-4-yl) amino substituted compounds of the general formula (I ) </p> <p> SPACE FOR FORMULA </p> <p> and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8 , R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer. </p> < p> </p>

Cdk2/4/6 inhibitors

This invention relates to compounds of general Formula (I) (see formula I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including certain cancers.

Enclosure apparatus for retaining devices within a computer

ENCLOSURE APPARATUS FOR RETAINING DEVICES WITHIN A COMPUTER ABSTRACT OF THE DISCLOSURE A computer enclosure is provided which is capable of accommodating a plurality of drive devices therein in as fashion whereby the drive devices are readily removable. The enclosure includes a box having first and second opposed sides and a substantially rectangular opening extending between the first and second sides. The enclosure further includes a drive device retainer member having first and second opposed ends, the first end of the retainer being removably pivotally attachable to the first end of the box, the second end of the retainer member being attachable to the second side of the box. The retainer member contacts the drive devices to hold the drive devices in the box. The enclosure further includes a bezel structure having first and second opposed ends. The bezel structure is situated atop the retainer member, the first end of the bezel structure being removable pivotally attachable to the second side of the box, the remaining first end of the bezel structure being removably attachable to the first end of the box so as to hold the retainer member on the box.

TRIARILOXIARILOXIPIRIMIDIN-2,4,6-TRIONA METALOPROTEINASE INHIBITORS.

Un compuesto de **fórmula**, en la que R1 se selecciona del grupo constituido por hidrógeno, (R2)2n+1-(C)n- y cicloalquilo (C3-C7); pudiendo estar opcionalmente sustituido el citado cicloalquilo (C3- C7) en cualquier átomo de carbono de anillo capaz de soportar un sustituyente adicional con uno a dos sustituyentes independientemente seleccionados del grupo constituido por halo, alquilo (C1-C4), alquenilo (C1-C4), alquinilo (C1-C4), R3-, R3-O-, perfluoroalcoxi (C1-C4), R3- alquil (C1-C4)-O-, R3-(C=O)-O-, (R3)2N-(C=O)-O-, -NO2, (R3)2N-, R3-(C=O)-(NR4)-, R3-(SO2)-(NR4)-, R3O-(C=O)-(NR4)-, (R3)2-N-(C=O)-(NR4)-, R3-S-, R3-(S=O)-, R3-(SO2)-, (R3)2N- (SO2)-, -CN, R3-(C=O)-, R3-O-(C=O)- y (R3)2N-(C=O)-; o una sal farmacéutica aceptable del mismo.

Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors

Apparatus for reducing electromagnetic radiation from a computer device

APPARATUS FOR REDUCING ELECTROMAGNETIC RADIATION FROM A COMPUTER DEVICE ABSTRACT OF THE DISCLOSURE A shielding strip is provided for a computer including an electrically conductive housing and a non-conductive drive mounting structure situated within the housing. The drive mounting structure includes a plurality of bays which communicate with an opening in the housing. An electrically conductive retainer is situated over the opening to hold the disk drives in the bays. The shielding strip includes a longitudinal main portion extending along a first side of the housing adjacent the opening and situated between the first side of the housing and the drive mounting structure. The shielding strip further includes a plurality of spring structures extending laterally away from the main portion and toward the bays, each of such spring structures including a first spring portion for contacting the retainer and a second spring portion for contacting a conductive portion of a disk drive mounted in a respective bay.

Systems and methods for uniform, cross-platform transactions

A cross-platform integration component is configured for operation on a plurality of different types of partner computing devices and/or platforms. The integration component provides a same interface on each different type of computing device. The integration component comprises a plurality of implementation modules, each configured to implement reader-based transactions on a respective type of computing device and/or platform. The integration component may further comprise a platform-independent component capable of implementing non-reader-based transactions across the plurality of platforms.

Printed circuit board interconnect apparatus

A personal computer system unit has a planar card (10) upon which is mounted a processor card (10). The processor has mounted thereon those components, except for system memory, which are most likely to be replaced for a system upgrade. The processor card (10) has a printed circuit board with printed circuits thereon that terminate along one edge at contacts (176). Two aligned edge connectors (100,101) are mounted on the planar board (50). One connector (100) has a key (173) which engages a slot (169) on the edge (48) of the processor card (10) to align the many contacts (176) with contact arms (186). Two levers (210) are mounted on the card (10) and cooperate with frame elements (201) to insert, extract and latch the processor card (10). Each element (201) also has a guide to align the processor card (10) for insertion into the edge connectors (100,101).

Ratchet lock for an intramedullary nail locking bolt

Pyridopyrimdinone cdk2/4/6 inhibitors

Sulfonyl amide derivatives for the treatment of abnormal cell growth

The present invention relates to a compound of the formula (I) wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Methods of preparing clusterboron

The invention provides new methods for synthesis of ClusterBoron (B 18 H 22 ). Preferred methods of the invention include in situ generation of the conjugate acid of B 20 H 18 2− and degradation of the acid in solution to produce B 18 H 22 in high yields and high purity. The invention further provides isotopically enriched boranes, particularly isotopically enriched 10 B) 18 H 22 and 11 B 18 H 22 .

Method and compositions for breeding for preferred traits associated with goss` wilt resistance in plants

The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot (GLS), a fungal disease associated with Cercospora spp. The invention further includes a method for breeding corn plants containing QTL that are associated with Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.

Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors

The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors of the formula (I) wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G and W are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Device adapter tray

A disk drive adapter tray (200) is provided for facilitating the mounting of a first size disk drive in a bay of a computer wherein the bay is capable of housing a second size disk drive which is larger than the first size disk drive. The tray includes a main body on which the first size disk drive is mountable. The main body includes first and second opposed side surfaces. First and second substantially parallel rails (320, 325) are integrally formed into the first and second side surfaces, respectively, of the main body. The first and second rails extending outwardly away from the first and second surfaces in opposite directions to engage rail guides situated within the bay in which the adapter tray is to be mounted.

Pyridopyrimdinone cdk2/4/6 inhibitors

This invention relates to compounds of general Formula (I), and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Enclosure for a computer

Shielding strip for a computer

Grounding apparatus for rail-mounted devices employed in a computer

GROUNDING APPARATUS FOR RAIL-MOUNTED DEVICES EMPLOYED IN A COMPUTER ABSTRACT OF THE DISCLOSURE A grounding structure is provided for a disk drive rail wherein the rail includes two sides, one side of which is mountable on a side of a disk drive or other rail mounted device. The grounding structure includes a substantially flat main body extending laterally along one side of the rail to a first end of the rail. The grounding structure further includes a wrap around portion extending from the main body at the first end of the rail and around the first end of the rail and further extending along a portion of the remaining side of the rail so as to hold the grounding structure to the rail. The wrap around portion is connectable to a ground contact adjacent thereto.

Pyrazolospiroketone acetyl-CoA carboxylase inhibitors

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R 1 , R 2 , and R 3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.

Improved flat support structure for printed circuit boards.

Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors

The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R 1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

DERIVATIVES OF SULFONIL AMIDA FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH

Reivindicacion 1: Un compuesto caracterizado porque es de formula 1, o una sal farmacéuticamente aceptable del mismo; en la que A es un resto anillo seleccionado entre el grupo constituido por: (a) carbociclilo de 4 a 7 miembros, (b) heterociclilode 4 a 7 miembros, (c) fenilo, y (d) anillo de heteroarilo de 5 a 6 miembros, en el que cada uno de dicho carbociclilo de 4 a 7 miembros y heterociclilo de 4 a 7 miembros de dicho grupo A puede contener opcionalmente uno o dos enlaces olefínicos; yen el que uno o dos átomos de carbono en el anillo en cada uno de dicho carbociclilo de 4 a 7 miembros y heterociclilo de 4 a 7 miembros de dicho grupo A puede reemplazarse independientemente opcionalmente por uno o dos restos seleccionadosindependientemente entre el grupo constituido por -C(O)-, -C(S)- y -C(=NR4)-; B es fenilo o un heteroarilo de 5 a 6 miembros; K es CH, C(NH2) o N; cada R1 se selecciona independientemente entre el grupo constituido por -H, halo, -CF3, -CN, -NO2, -NR7R8, NR7C(NR7R8)(=CR9), -CR7(NR7R8)(=NR7), -NR7C(NR7R8)(=NR7), -NR7C(O)R9, -C(O)NR7R8, -C(O)R9, -C(O)C(O)R9, -C(O)OR10, -OC(O)R9, -OR10, -OC(O)OR10, -S(O)jR11, -S(O)(=NR7)R8, -alquilo C1-6, -alquenilo C2-6, -alquinilo C2-6, -cicloalquilo C3-10, -cicloalquenilo C5-10, -bicicloalquilo C6-10, -bicicloalquenilo C6-10, -heterocicloalquilo C1-9, -heterocicloalquenilo C4-9, -heterobicicloalquilo C6-9, -heterobicicloalquenilo C6-9, -arilo C6-10, y -heteroarilo C1-9; y en el que cada uno de losrestos anteriores -alquilo C1-6, -alquenilo C2-6, -alquinilo C2-6, -cicloalquilo C3-10, -cicloalquenilo C5-10, -heterocicloalquilo C1-9, -heterocicloalquenilo C4-9, -arilo C6-10, y -heteroarilo C1-9; de dicho R1 está sustituido opcionalmenteindependientemente con de uno a tres grupos R12; cada uno de R2 y R3 se selecciona independientemente entre el grupo constituido por -H, -halo, -OR10, -alquilo C1-6, -alquenilo C2-6, -alquinilo C2-6, -cicloalquilo C3-10, -cicloalquenilo C5-10, -heterocicloalquilo C2-9, - ...

Pyrazolospiroketone acetyl-coa carboxylase inhibitors

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.

Equipotential bonding structure for devices used in a computer and mounted on rails.

Pyridopyrimdinone cdk2/4/6 inhibitors

Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

INHIBITORS TRIARILOXIARILOXIPIRIMIDIN-2,4,6-METALOPROTEINASE TRION

LA PRESENTE INVENCION SE REFIERE A INHIBIDORES TRIARILOXIARILOXIPIRIMIDIN-2,4,6-TRIONA DE METALOPROTEINASA DE FORMULA I EN LA QUE X, A, Y, B, G, W Y R1 SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA, Y A COMPOSICIONES FARMACEUTICAS Y PROCEDIMIENTOS DE TRATAMIENTO DE LA INFLAMACION, EL CANCER Y OTROS TRASTORNOS. THE PRESENT INVENTION CONCERNS TRIARILOXIARILOXIPIRIMIDIN-2,4,6-TRIONA METALOPROTEINASE INHIBITORS OF FORMULA I IN WHICH X, A, Y, B, G, WY R1 ARE AS DEFINED IN THE DESCRIPTIVE MEMORY, AND PHARMACEUTICAL PROCESSING COMPOSITIONS OF TREATMENT OF INFLAMMATION, CANCER AND OTHER DISORDERS.

Pyridopyrimdinone cdk2/4/6 inhibitors

Hip stem centralizer datum guide, and method

A hip stem centralizer datum guide and method are provided for positioning a proximal portion of a hip stem component within bone cement in an intramedullary canal of a femur. The datum guide is positionable in a predetermined position relative to the intramedullary canal and is able to create a datum that records the predetermined hip stem component position relative to the intramedullary canal. The datum is able to be referenced to position the hip stem component in the predetermined hip stem component position in the bone cement in the intramedullary canal.

Personal computer processor card interconnect system

A personal computer system unit has a planar card upon which is mounted a processor card. The processor has mounted thereon those components, except for system memory, which are most likely to be replaced for a system upgrade. The processor card has a printed circuit board with printed circuits thereon that terminate along one edge at contacts. Two aligned edge connectors are mounted on the planar board. One connector has a key which engages a slot on the edge of the processor card to align the many contacts with contact arms. Two levers are mounted on the card and cooperate with frame elements to insert, extract and latch the processor card. Each element also has a guide to align the processor card for insertion into the edge connectors.