Method and Device for Application of Fluid Forces to Cells

A system and method of determining biomechanical properties of a cell. A cell is introduced into a multiport flow device, the device being configured such that during fluid flow at least one stagnation zone arises in an expected location within the device. The cell is trapped in the stagnation zone of the device. A selected physical stimulus is applied to the cell, such as rotation, stretching or time-varying shear rate. The cell is observed while trapped to detect an absolute, differential and/or transient effect of the applied physical stimulus and to thereby determine biomechanical properties of the cell. Disease diagnosis may follow, by comparison to a normal control. Selectively directing the cell to a chosen outlet based on observed properties provides cell sorting, which may be implemented in parallel to increase throughput and/or in series to enlarge sorting criteria. Micro-particles may be investigated by use of appropriate particle model. 1. A method of determining biomechanical properties of a cell , the method comprising:introducing the cell into a multiport flow device, the device being configured such that during fluid flow at least one stagnation zone arises in an expected location within the device;trapping the cell in the stagnation zone of the device;applying a selected physical stimulus to the cell; andobserving the cell while trapped to detect an effect of the applied physical stimulus and to thereby determine biomechanical properties of the cell.2. The method of wherein the cell is a red blood cell and the biomechanical property is the stiffness of the red blood cell as determined in response to the selected physical stimulus.3. The method of claim 2 , further comprising giving a diagnosis of a disease comprising one of diabetes claim 2 , cancer claim 2 , obesity and malaria.4. A device for determining biomechanical properties of a cell claim 2 , the device comprising:a plurality of fluid ports communicating with a fluid chamber, the ports and ...

Tooth whitening product

A tooth whitening product comprises a multi-phase oral composition contained in a package. The multi-phase composition comprises a hydrophobic phase comprising a flavor, and a hydrophilic phase comprising a peroxide bleaching agent. The package comprises a container formed of an oxygen-permeable substrate comprising one or more layers, wherein the substrate has an oxygen transmission rate at 23° C. of at least about 5 cc/(m2*day) and the substrate is free of a barrier layer. A dispensing orifice in fluid communication with the container is covered by a cap.

ORAL CARE PRODUCT

An oral care product comprises a package comprising a container and an applicator tip attached to the container. The applicator tip comprises a material having a Shore A hardness of from about 15 to about 80 and has a dispensing orifice in fluid communication with the container. The dispensing orifice has a minimum diameter of at least about 0.5 mm, preferably at least about 1 mm. The oral care product further comprises an oral care composition contained within the container of the package, wherein the oral care composition comprises an oral care active and has a cone penetration value of from about 10 to about 500, preferably from about 100 to about 300. 1. An oral care product comprising:a package comprising a container and an applicator tip attached to the container, wherein the applicator tip comprises a material having a Shore A hardness of from about 15 to about 80 and has a dispensing orifice in fluid communication with the container, the dispensing orifice having a minimum diameter of at least about 0.5 mm; andan oral care composition contained within the container of the package, wherein the oral care composition comprises an oral care active and has a cone penetration value of from about 10 to about 500.2. The oral care product of claim 1 , wherein the minimum diameter is at least about 1 mm.3. The oral care product of claim 1 , wherein the cone penetration value is from about 100 to about 300.4. The oral care product of claim 1 , wherein the applicator tip comprises a tooth-contacting surface surrounding the dispensing orifice.5. The oral care product of claim 4 , wherein the applicator tip has a longitudinal axis claim 4 , wherein the tooth-contacting surface forms an angle relative to the longitudinal axis of from about 20° to about 80°.6. The oral care product of claim 5 , wherein the angle relative to the longitudinal axis is from about 30° to about 60°.7. The oral care product of claim 6 , wherein the angle relative to the longitudinal axis is from ...

Oral care compositions comprising peroxide and alumina

Oral care compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, uncalcined alumina, and optionally water. Methods of use to whiten teeth using one or more of the disclosed compositions.

HYDRATING ORAL CARE COMPOSITIONS COMPRISING PEROXIDE

Hydrating oral care compositions including peroxide and water. Hydrating dentifrice compositions including peroxide and water. Hydrating oral care compositions including peroxide and water that can release at least about 1% of the peroxide within 120 seconds. Hydrating oral care compositions including peroxide and water that can release at least about 15% of the peroxide within 15 minutes. 2. The oral care composition of claim 1 , wherein the peroxide comprises hydrogen peroxide claim 1 , urea peroxide claim 1 , carbamide peroxide claim 1 , calcium peroxide claim 1 , sodium peroxide claim 1 , zinc peroxide claim 1 , sodium percarbonate claim 1 , polyvinylpyrrolidone-hydrogen peroxide complex claim 1 , cross-linked polyvinyl pyrrolidone-hydrogen peroxide complex claim 1 , or combinations thereof.3. The oral care composition of claim 1 , wherein the oral care composition comprises at least about 1% claim 1 , by weight of the oral care composition claim 1 , of the peroxide.4. The oral care composition of claim 1 , wherein the oral care composition comprises at least about 3% claim 1 , by weight of the oral care composition claim 1 , of the peroxide.5. The oral care composition of claim 1 , wherein the oral care composition comprises at least about 3.5% claim 1 , by weight of the oral care composition claim 1 , of the peroxide.6. The oral care composition of claim 1 , wherein the oral care composition comprises from about 5% claim 1 , to about 75% claim 1 , by weight of the oral care composition claim 1 , of the water.7. The oral care composition of claim 1 , wherein the oral care composition comprises abrasive claim 1 , the abrasive comprising silica claim 1 , alumina claim 1 , calcium abrasive claim 1 , or combinations thereof.8. The oral care composition of claim 7 , wherein the calcium abrasive comprises calcium carbonate claim 7 , calcium phosphate claim 7 , calcium pyrophosphate claim 7 , or combinations thereof.9. The oral care composition of claim 7 , wherein ...

Oral Care Compositions Comprising Medium Length Polyphosphates

An oral care composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A mouth rinse composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. 1. An oral care composition comprising:(a) about 20% or greater, by weight of the oral care composition, of water;(b) a polyphosphate source comprising a first linear polyphosphate with an average chain length of from about 6 to about 21;(c) a pH of about 5 or less, andwherein the composition has a ΔE of about 3 or less.2. The oral care composition of claim 1 , wherein the polyphosphate source further comprises a second linear polyphosphate with an average chain length of from about 2 to about 6.3. The oral care composition of claim 2 , wherein the dentifrice has a ratio of the first polyphosphate to the second polyphosphate is from about 6:1 to about 1:1.4. The oral care composition of claim 2 , wherein the ratio of the first linear polyphosphate to the second linear polyphosphate source is from 4:1 to 1:15. The oral care composition of claim 2 , wherein the oral care composition comprises from about 2% to about 12% claim 2 , by weight of the oral care composition claim 2 , of the polyphosphate source.6. The oral care composition of claim 2 , wherein the second linear polyphosphate comprises a pyrophosphate ion claim 2 , a tripolyphosphate ion claim 2 , or sodaphos polyphosphate ion.7. The oral care composition of claim 1 , wherein the oral care composition is free of a peroxide claim 1 , oxidizer claim 1 , an enzyme claim 1 , calcium pyrophosphate claim 1 , an alcohol claim 1 , or a paraben.8. The oral care composition of further comprising a surfactant.9. The oral care composition of further comprising polyvinylpyrrolidone.10. The oral care composition of claim 1 , wherein the first linear polyphosphate ...

Multi-Phase Oral Care Compositions

Multi-phase oral care compositions for whitening teeth. including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A multi-phase oral care composition comprising:a) solid hydrophilic bleaching agent particles, wherein at least 20 parts by weight of the solid hydrophilic bleaching agent particles are soluble in 100 parts, by weight of water; andb) at least about 60%, by weight of the multi-phase oral care composition, of hydrophobic phase.2. (canceled)3. The multi-phase oral care composition of claim 1 , wherein at least 50 parts by weight of the hydrophilic bleaching agent particles are soluble in 100 parts by weight of water.4. The multi-phase oral care composition of claim 3 , wherein the hydrophilic bleaching agent particles comprise hydrogen peroxide adduct.5. The multi-phase oral care composition of claim 4 , wherein the hydrogen peroxide adduct comprises urea peroxide claim 4 , polyvinyl pyrrolidone complexed with peroxide claim 4 , or combinations thereof.6. The multi-phase oral care composition of claim 1 , wherein the hydrophilic bleaching agent particle swells by at least about 50% upon contact with water.7. The multi-phase oral care composition of claim 1 , wherein the hydrophilic bleaching agent particle is insoluble in the hydrophobic phase and the hydrophobic phase is insoluble in water.8. The multi-phase oral care composition of claim 1 , wherein the multi-phase oral care composition has a cone penetration consistency value of from about 25 to about 300.9. The multi-phase oral care composition of claim 1 , wherein the hydrophobic phase has a cone penetration consistency value of from about 50 to about 250.10. ...

Semisolid Oral Dispersions Comprising Active Agents

Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Semisolid Oral Dispersions Comprising Active Agents

The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A semisolid oral dispersion comprising:a) solid hydrophilic active agent particles;b) at least about 50%, by weight of the dispersion, of hydrophobic phase.2. The semisolid oral dispersion of claim 1 , wherein at least about 20 parts by weight of the hydrophilic active agent particles are soluble in about 100 parts by weight of water.3. The semisolid oral dispersion of claim 2 , wherein at least about 50 parts by weight of the hydrophilic active agent particles are soluble in about 100 parts by weight of water4. The semisolid oral dispersion of claim 3 , wherein the hydrophilic active agent particles comprise healing agent claim 3 , anticalculus agent claim 3 , anticaries agent claim 3 , antimicrobial agent claim 3 , dentinal desensitizing agent claim 3 , anesthetic agent claim 3 , antifungal agent claim 3 , coolant claim 3 , anti-inflammatory agent claim 3 , selective H-2 antagonist claim 3 , anticaries agent claim 3 , nutrient claim 3 , erythritol claim 3 , probiotic claim 3 , hydrophilic bleaching agent claim 3 , tooth whitening agent claim 3 , or mixtures thereof.5. The semisolid oral dispersion of claim 4 , wherein the healing agent comprises hyaluronic acid or salts claim 4 , glucosamine or salts claim 4 , allantoin claim 4 , curcumin claim 4 , D panthenol claim 4 , niacinamide claim 4 , ellagic acid claim 4 , flavanoids claim 4 , vitamin E claim 4 , ubiquinone claim 4 , or combinations thereof.6Lactobacillus reuteriLactobacillus salivariusLactobacillus paracaseiStreptococcus salivariusBifidobacteriumL. paracaseiS. OralisS. rattusS. uberisLactobacillus, ...

Semisolid Oral Dispersions Comprising Bleaching Agents

Semisolid oral dispersions for whitening teeth. The semisolid oral dispersions include hydrophilic bleaching agent particles in a hydrophobic phase. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A semisolid oral dispersion comprising:a) solid hydrophilic bleaching agent particles;b) at least about 50%, by weight of the dispersion, of hydrophobic phase.2. The semisolid oral dispersion of claim 1 , wherein at least about 20 parts by weight of the hydrophilic bleaching agent particles are soluble in about 100 parts by weight of water.3. The semisolid oral dispersion of claim 2 , wherein at least about 50 parts by weight of the hydrophilic bleaching agent particles are soluble in about 100 parts by weight of water4. The semisolid oral dispersion of claim 3 , wherein the hydrophilic bleaching agent particles comprise hydrogen peroxide adduct.5. The semisolid oral dispersion of claim 4 , wherein the hydrogen peroxide adduct comprises urea peroxide claim 4 , polyvinyl pyrrolidone complexed with peroxide claim 4 , or combinations thereof.6. The semisolid oral dispersion of claim 1 , wherein the hydrophilic bleaching agent particle swells by at least about 50% upon contact with water.7. The semisolid oral dispersion of claim 1 , wherein the hydrophilic bleaching agent particle is insoluble in the hydrophobic phase and the hydrophobic phase is insoluble in water.8. The semisolid oral dispersion of claim 1 , wherein the dispersion has a cone penetration consistency value of from about 25 to about 300.9. The semisolid oral dispersion of claim 1 , wherein the hydrophobic phase has a cone penetration consistency value of from about 25 to about 300.10. The semisolid oral dispersion of claim 1 , wherein the dispersion has a drop melting point of from ...

Device For Applying Emulsion Compositions

An applicator device for the application of hydrophobic compositions to hydrophilic surfaces. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges. 130. An applicator tip () comprising:{'b': '31', '(a) at least one external ridge ();'}{'b': '32', '(b) a plurality of internal ridges (); and'}{'b': 33', '32, '(c) a plurality of internal channels () between the plurality of internal ridges (),'}{'b': 30', '31, 'wherein at least a portion of a perimeter of the applicator tip () is free from the at least on external ridge ().'}23030. The applicator tip () of claim 1 , wherein the applicator tip () has a durometer rating of from about 45 A to about 75 A.33030. The applicator tip () of claim 1 , wherein the application tip () is colored.43032. The applicator tip () of claim 1 , wherein a portion of the plurality of internal ridges () are substantially straight.53032. The applicator tip () of claim 1 , wherein a portion of the plurality of internal ridges () are curved.6303232. The applicator tip () of claim 1 , wherein a first portion of the plurality of internal ridges () are substantially straight and a second portion of the plurality of internal ridges () are curved.73032. The applicator tip () of claim 1 , wherein the plurality of internal ridges () comprises from 2 to about 20 internal ridges.83031. The applicator tip () of claim 1 , wherein the at least one external ridge () comprises a plateau.93030. The applicator tip () of claim 1 , wherein the applicator tip () is made from an elastomer.1030. The applicator tip () of claim 9 , wherein the elastomer is a thermoplastic elastomer claim 9 , a styrenic claim 9 , a copolyester claim 9 , a polyurethane claim 9 , a polyamide claim 9 , a polyolefin blend claim 9 , a polyolefin alloy claim 9 , a reactor TPO claim 9 , a polyolefin ...

Kit For Applying Emulsion Compositions

A kit for the application of hydrophobic compositions to hydrophilic surfaces with an applicator device and a container for the hydrophobic composition. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges. A container with a ribbon orifice for the dispensing of the emulsion composition. 1. A kit for applying an oral care composition to an oral cavity surface comprising:{'b': 10', '10, 'claim-text': [{'b': '31', '(i) at least one external ridge (),'}, {'b': '32', '(ii) a plurality of internal ridges (), and'}, {'b': 33', '32, '(iii) a plurality of internal channels () between the plurality of internal ridges (); and'}], '(a) an applicator device (), the applicator device () comprising{'b': 50', '50, 'claim-text': [{'b': 51', '52, '(i) a nozzle () comprising a ribbon orifice (), and'}, {'b': '54', '(ii) a storage portion ().'}], '(b) a container () for the oral care composition, the container () comprising231. The kit of claim 1 , wherein the at least one external ridge () has a first height and the plurality of internal ridges has a second height claim 1 , and the first height is greater than the second height.310353132. The kit of claim 2 , wherein the applicator device () comprises an internal cavity () formed from the difference in heights of the at least one external ridge () and the plurality of internal ridges ().41030. The kit of claim 1 , wherein the applicator device () comprises an applicator tip () with a durometer rating of from about 45 A to about 75 A.530. The kit of claim 4 , wherein the application tip () has a durometer rating of from about 60 A to about 70 A.632. The kit of claim 1 , wherein the plurality of internal ridges () comprises from 2 to about 20 internal ridges.730. The kit of claim 1 , wherein the applicator tip () is made from an elastomer.8. The ...

Multi-Phase Oral Care Compositions

Multi-phase oral care compositions for whitening teeth, including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A multi-phase oral care composition comprising:a) solid hydrophilic bleaching agent particles, wherein the solid hydrophilic bleaching agent particles comprise urea peroxide, polyvinyl pyrrolidone complexed with hydrogen peroxide, or combinations thereof; andb) at least about 60%, by weight of the multi-phase oral care composition, of hydrophobic phase.2. The multi-phase oral care composition of claim 1 , wherein the hydrophilic bleaching agent particle is insoluble in the hydrophobic phase and the hydrophobic phase is insoluble in water.3. The multi-phase oral care composition of claim 1 , wherein the multi-phase oral care composition has a cone penetration consistency value of from about 25 to about 300.4. The multi-phase oral care composition of claim 1 , wherein the hydrophobic phase has a cone penetration consistency value of from about 50 to about 250.5. The multi-phase oral care composition of claim 1 , wherein the multi-phase oral care composition has a cone penetration consistency value of from about 50 to about 250.6. The multi-phase oral care composition of claim 1 , wherein the hydrophobic phase comprises mineral oil thickened with wax claim 1 , mineral oil thickened with polyethylene claim 1 , petrolatum claim 1 , or combinations thereof.7. The multi-phase oral care composition of claim 1 , wherein the hydrophobic phase comprises petrolatum.8. The multi-phase oral care composition of claim 7 , wherein the solid hydrophilic bleaching agent particles comprise urea peroxide.9. The multi-phase oral ...

Multi-Phase Oral Care Compositions

Multi-phase oral care compositions for whitening teeth including hydrophilic bleaching agent particles in a hydrophobic phase with a cone penetration consistency value of from about 25 to about 300. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A multi-phase oral care composition comprising:a) solid hydrophilic bleaching agent particles;b) at least about 50%, by weight of the multi-phase oral care composition, of hydrophobic phase,wherein the multi-phase oral care composition has a cone penetration consistency value of from about 25 to about 300.2. The multi-phase oral care composition of claim 1 , wherein at least about 20 parts by weight of the hydrophilic bleaching agent particles are soluble in about 100 parts by weight of water.3. The multi-phase oral care composition of claim 2 , wherein at least about 50 parts by weight of the hydrophilic bleaching agent particles are soluble in about 100 parts by weight of water4. The multi-phase oral care composition of claim 3 , wherein the hydrophilic bleaching agent particles comprise hydrogen peroxide adduct.5. The multi-phase oral care composition of claim 4 , wherein the hydrogen peroxide adduct comprises urea peroxide claim 4 , polyvinyl pyrrolidone complexed with peroxide claim 4 , or combinations thereof.6. The multi-phase oral care composition of claim 1 , wherein the hydrophilic bleaching agent particle swells by at least about 50% upon contact with water.7. The multi-phase oral care composition of claim 1 , wherein the hydrophilic bleaching agent particle is insoluble in the hydrophobic phase and the hydrophobic phase is insoluble in water.8. The multi-phase oral care composition of claim 1 , wherein the multi-phase oral care composition has a cone penetration consistency value of ...

Multi-Phase Oral Care Compositions

Semisolid oral dispersions for whitening teeth including hydrogen peroxide adducts in petrolatum. The hydrogen peroxide adduct can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The semisolid oral dispersion and/or the petrolatum can have a cone penetration consistency value of from about 25 to about 300. 2. The semisolid dispersion of claim 1 , wherein the hydrogen peroxide adduct comprises urea peroxide claim 1 , polyvinyl pyrrolidone complexed with peroxide claim 1 , or combinations thereof.3. The semisolid oral dispersion of claim 1 , wherein hydrogen peroxide adduct swells by at least about 50% upon contact with water.4. The semisolid oral dispersion of claim 1 , wherein the hydrogen peroxide adduct has a water solubility of at least about 20 parts claim 1 , by weight of the adduct claim 1 , in about 100 parts claim 1 , by weight claim 1 , of water.5. The semisolid oral dispersion of claim 1 , wherein hydrogen peroxide adduct is insoluble in the petrolatum and the petrolatum is insoluble in water.6. The semisolid oral dispersion of claim 1 , wherein the dispersion has a cone penetration consistency value of from about 50 to about 250.7. The semisolid oral dispersion of claim 1 , wherein the petrolatum has a cone penetration consistency value of from about 50 to about 250.8. The semisolid oral dispersion of claim 1 , wherein the dispersion has a drop melting point of from about 40° C. to about 80° C.9. The semisolid oral dispersion of claim 1 , wherein the dispersion has a bleaching efficacy of at least about 1.10. The semisolid oral dispersion of claim 9 , wherein the dispersion has a ratio of the bleaching efficacy to the weight percentage of hydrophilic bleaching agent particles present in the dispersion of at least about 1.11. A method for whitening teeth comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a) applying the semisolid oral dispersion of to a delivery carrier; ...

Multi-Phase Oral Care Compositions

Semisolid oral dispersions for whitening teeth comprising a hydrophilic discontinuous phase and a hydrophobic continuous phase. The semisolid oral dispersions include a hydrophilic discontinuous phase comprising bleaching agent particles. The semisolid oral dispersions also include a hydrophobic continuous phase comprising petrolatum. The h bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. 1. A semisolid oral dispersion comprising:a) hydrophilic discontinuous phase comprising bleaching agent particles; andb) hydrophobic continuous phase comprising petrolatum.2. The semisolid oral dispersion of claim 1 , wherein at least about 20 parts by weight of the bleaching agent particles are soluble in about 100 parts by weight of water.3. The semisolid oral dispersion of claim 2 , wherein at least about 50 parts by weight of the bleaching agent particles are soluble in about 100 parts by weight of water4. The semisolid oral dispersion of claim 3 , wherein the bleaching agent particles comprise hydrogen peroxide adduct.5. The semisolid oral dispersion of claim 4 , wherein the hydrogen peroxide adduct comprises urea peroxide claim 4 , polyvinyl pyrrolidone complexed with peroxide claim 4 , or combinations thereof.6. The semisolid oral dispersion of claim 1 , wherein the bleaching agent particles swell by at least about 50% upon contact with water.7. The semisolid oral dispersion of claim 1 , wherein the bleaching agent particles are insoluble in the hydrophobic phase and the hydrophobic phase is insoluble in water.8. The semisolid oral dispersion of claim 1 , wherein the dispersion has a cone penetration consistency value of from about 25 to about 300.9. The semisolid oral dispersion of claim 1 , wherein the hydrophobic phase has a cone penetration consistency value of from about 25 ...

Oral care compositions comprising peroxide and alumina

Oral care compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, uncalcined alumina, and optionally water. Methods of use to whiten teeth using one or more of the disclosed compositions.

Stain removing oral care compositions comprising medium length polyphosphates

An oral care composition with one or more polyphosphates with about 20 wt% or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt% or more of water at a pH of about 5 or less. A mouth rinse composition with one or more polyphosphates with about 20 wt% or more of water at a pH of about 5 or less.

Kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Oral care compositions comprising dicarboxylic acid

Oral care compositions including dicarboxylic acid and a pH of from about 4 to about 6. Oral care kits including a first oral care composition with fluoride and a second oral care composition with dicarboxylic acid. Oral care compositions including fluoride and dicarboxylic acid that provide an erosion benefit, a stain prevention benefit, and/or a stain removal benefit.

Semisolid oral dispersions comprising bleaching agents

Semisolid oral dispersions for whitening teeth. The semisolid oral dispersions include hydrophilic bleaching agent particles in a hydrophobic phase. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Kit for applying emulsion compositions

A kit for the application of hydrophobic compositions to hydrophilic surfaces with an applicator device and a container for the hydrophobic composition. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges. A container with a ribbon orifice for the dispensing of the emulsion composition.

Oral care product

An oral care product comprises a package comprising a container and an applicator tip attached to the container. The applicator tip comprises a material having a Shore A hardness of from about 15 to about 80 and has a dispensing orifice in fluid communication with the container. The dispensing orifice has a minimum diameter of at least about 0.5 mm, preferably at least about 1 mm. The oral care product further comprises an oral care composition contained within the container of the package, wherein the oral care composition comprises an oral care active and has a cone penetration value of from about 10 to about 500, preferably from about 100 to about 300.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values. Toothpaste compositions including jammed oil-in-water emulsion wherein the yield stress of the toothpaste composition can be modified through physical manipulation. Arrays of oral care compositions including a first jammed oil-in-water emulsion toothpaste composition including oral care active agent and a second oral care composition including peroxide.

Device for applying emulsion compositions

An applicator device for the application of hydrophobic compositions to hydrophilic surfaces. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges.

Oral care compositions comprising dicarboxylic acid

Oral care compositions including dicarboxylic acid and fluoride. Oral care kits including a first oral care composition with fluoride and a second oral care composition with dicarboxylic acid. Oral care compositions including fluoride and dicarboxylic acid that provide an enhanced anticaries benefit, a stain prevention benefit, and/or a stain removal benefit.

Kit comprising an electromagnetic radiation source, a deliver carrier and a semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition in form of a dispersion for whitening teeth applied on a delivery carrier.

Methods of making 6-[(4,5-dihydro-1h-imidazol-2-yl)amino-]-7-methyl-1h-benzimidazole-4-carbonitrile and its preferred salt form

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form

Semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Multi-phase oral care compositions

Semisolid oral dispersions for whitening teeth including hydrogen peroxide adducts in petrolatum. The hydrogen peroxide adduct can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The semisolid oral dispersion and/or the petrolatum can have a cone penetration consistency value of from about 25 to about 300.

Kit comprising a carrier and a semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A kit comprising a semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Semisolid oral dispersions comprising active agents

Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

PROCESS FOR THE PREPARATION OF 6-E (4,5-DIHYDRO-1H-IMIDAZOLE-2-YL) AMINO-U-7-METHYL-1H-BENZIMIDAZOLE-4-CARBONITRILE AND ITS PREFERRED SALT FORM

Methods of making 6-[(4,5-dihydro-1h-imidazol-2-yl)amino-]-7-methyl-1h-benzimidazole-4-carbonitrile and its preferred salt form

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

COMPOSITIONS FOR ORAL TREATMENT COMPRISING DICARBOXYLIC ACID

COMPOSIÇÕES PARA TRATAMENTO BUCAL COMPREENDENDO ÁCIDO DICARBOXÍLICO. Trata-se de composições para tratamento bucal que incluem ácido dicarboxílico e fluoreto. A invenção revela, também, kits para tratamento bucal incluindo uma primeira composição para tratamento bucal com fluoreto e uma segunda composição para tratamento bucal com ácido dicarboxílico. Composições para tratamento bucal que incluem fluoreto e ácido dicarboxílico que fornecem um benefício anticárie intensificado, um benefício de prevenção de manchas e/ou um benefício de remoção de manchas. ORAL TREATMENT COMPOSITIONS COMPRISING DICARBOXYLIC ACID. These are oral care compositions comprising dicarboxylic acid and fluoride. The invention also provides oral care kits including a first fluoride oral care composition and a second dicarboxylic acid oral care composition. Oral care compositions that include fluoride and dicarboxylic acid that provide an enhanced anticaries benefit, a stain prevention benefit, and/or a stain removal benefit.

Semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Oral care compositions comprising dicarboxylic acid

Oral care compositions including dicarboxylic acid and fluoride. Oral care kits including a first oral care composition with fluoride and a second oral care composition with dicarboxylic acid. Oral care compositions including fluoride and dicarboxylic acid that provide an enhanced anticaries benefit, a stain prevention benefit, and/or a stain removal benefit.

Oral care compositions comprising peroxide and alumina

Oral care compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, uncalcined alumina, and optionally water. Methods of use to whiten teeth using one or more of the disclosed compositions.

Methods of making 6-[(4,5-dihydro-1h-imidazol-2-yl)amino-]-7-methyl-1h-benzimidazole-4-carbonitrile and its preferred salt form

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

Composiciones para el cuidado bucal que comprenden acido dicarboxilico.

Composiciones para el cuidado bucal que incluyen ácido dicarboxílico y un pH de aproximadamente 4 a aproximadamente 6. Kits para el cuidado bucal que incluyen una primera composición para el cuidado bucal con fluoruro y una segunda composición para el cuidado bucal con ácido dicarboxílico. Composiciones para el cuidado bucal que incluyen fluoruro y ácido dicarboxílico que proporcionan un beneficio de erosión, un beneficio de prevención de manchas y/o un beneficio de eliminación de manchas.

Kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Semisolid multi-phase oral composition comprising hydrophilic active agent particles

A semisolid multi-phase oral composition in form of a semisolid dispersion for use in oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anti-calculus agents, and/or combinations thereof.

Kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition comprising hydrophilic bleaching agent particles

A kit comprising an electromagnetic radiation source and a semisolid multi-phase oral composition in form of a dispersion for whitening teeth.

Semisolid multi-phase oral composition comprising hydrophilic active agent particles

A semisolid multi-phase oral composition in form of a semisolid dispersion for use in oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anti-calculus agents, and/or combinations thereof.

Dispositivo para aplicar composiciones en emulsion.

Un dispositivo aplicador para la aplicación de composiciones hidrófobas a superficies hidrófilas. Un dispositivo aplicador para la aplicación de una composición en emulsión a dientes humedecidos. Una punta del aplicador con al menos un borde externo, una pluralidad de bordes internos y una pluralidad de canales internos entre la pluralidad de bordes internos.

Composiciones para el cuidado bucal que comprenden acido dicarboxilico.

Composiciones para el cuidado bucal que incluyen ácido dicarboxílico y fluoruro. Kits para el cuidado bucal que incluyen una primera composición para el cuidado bucal con fluoruro y una segunda composición para el cuidado bucal con ácido dicarboxílico. Composiciones para el cuidado bucal que incluyen fluoruro y ácido dicarboxílico que proporcionan un beneficio anticaries mejorado, un beneficio de prevención de manchas, y/o un beneficio de eliminación de manchas.

Kit para aplicar composiciones en emulsion.

Un kit para la aplicación de composiciones hidrófobas a superficies hidrófilas con un dispositivo aplicador y un recipiente para la composición hidrófoba. Un dispositivo aplicador para la aplicación de una composición en emulsión a dientes humedecidos. Una punta del aplicador con al menos un borde externo, una pluralidad de bordes internos y una pluralidad de canales internos entre la pluralidad de bordes internos. Un recipiente con un orificio de cinta para dispensar la composición en emulsión.

Oral care compositions comprising peroxide and alumina

Oral care compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, and optionally water. Dentifrice compositions including peroxide, calcined alumina, uncalcined alumina, and optionally water. Methods of use to whiten teeth using one or more of the disclosed compositions.

Hydrating oral care compositions comprising peroxide

Hydrating oral care compositions including peroxide and water. Hydrating dentifrice compositions including peroxide and water. Hydrating oral care compositions including peroxide and water that can release at least about 1% of the peroxide within 120 seconds. Hydrating oral care compositions including peroxide and water that can release at least about 15% of the peroxide within 15 minutes.

Tooth whitening product

A tooth whitening product comprises a multi-phase oral composition contained in a package. The multi-phase composition comprises a hydrophobic phase comprising a flavor, and a hydrophilic phase comprising a peroxide bleaching agent. The package comprises a container formed of an oxygen-permeable substrate comprising one or more layers, wherein the substrate has an oxygen transmission rate at 23°C of at least about 5 cc/(m2*day) and the substrate is free of a barrier layer. A dispensing orifice in fluid communication with the container is covered by a cap.

Tooth whitening product

A tooth whitening product comprises a multi-phase oral composition contained in a package. The multi-phase composition comprises a hydrophobic phase comprising a flavor, and a hydrophilic phase comprising a peroxide bleaching agent. The package comprises a container formed of an oxygen-permeable substrate comprising one or more layers, wherein the substrate has an oxygen transmission rate at 23°C of at least about 5 cc/(m2*day) and the substrate is free of a barrier layer. A dispensing orifice in fluid communication with the container is covered by a cap.

Tooth whitening product

A tooth whitening product comprises a multi-phase oral composition contained in a package. The multi-phase composition comprises a hydrophobic phase comprising a flavor, and a hydrophilic phase comprising a peroxide bleaching agent. The package comprises a container formed of an oxygen-permeable substrate comprising one or more layers, wherein the substrate has an oxygen transmission rate at 23°C of at least about 5 cc/(m2*day) and the substrate is free of a barrier layer. A dispensing orifice in fluid communication with the container is covered by a cap.

Multi-phase oral care compositions

Multi-phase oral care compositions for whitening teeth, including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Opaque jammed oil-in-water emulsion toothpaste compositions without an opacifier and/or abrasive. Toothpaste compositions including jammed oil-in-water emulsion wherein the opacity can be modified through physical manipulation. Toothpaste compositions comprising jammed oil-in-water emulsion wherein the toothpaste composition is opaque without a solid opacifier.

Jammed emulsion toothpaste compositions comprising fluoride

Jammed oil-in-water emulsion toothpaste compositions. Anticavity jammed oil-in-water emulsion toothpaste compositions including fluoride. Anticavity jammed oil-in-water emulsion toothpaste compositions including an unexpectedly low amount of fluoride, such as less than 500 ppm of fluoride. An array of oral care compositions including a first anticavity jammed oil-in-water emulsion toothpaste including fluoride and a whitening composition, such as a second jammed oil-in- water emulsion toothpaste including peroxide.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier. Jammed oil-in-water emulsion toothpaste compositions with a hydrophobic phase with a particular droplet size of from about 0.4 microns to about 1000 microns, which can lead to toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values. Toothpaste compositions including jammed oil-in-water emulsion wherein the yield stress of the toothpaste composition can be modified through physical manipulation. Arrays of oral care compositions including a first jammed oil-in-water emulsion toothpaste composition including oral care active agent and a second oral care composition including peroxide.

親水性有効成分粒子を含む半固体多相口腔用組成物

【課題】口腔内で使用するための、半固体分散体の形態の半固体多相口腔用組成物を提供する。【解決手段】半固体多相口腔用組成物であって、（ａ）前記多相口腔用組成物の約０．００１重量％～約５０重量％の親水性有効成分粒子と、（ｂ）前記多相口腔用組成物の少なくとも約５０重量％の疎水性相と、を含み、前記疎水性相及び／又は前記半固体多相口腔用組成物の円錐貫入稠度値が、約２５～約３００であり、前記半固体多相口腔用組成物が、半固体分散物である、半固体多相口腔用組成物とする。前記親水性有効成分粒子は、漂白剤、抗菌剤、抗結石剤、及び／又はこれらの組合せを含むことができる。【選択図】図１

Device for applying emulsion compositions

M-WO JC 20 ABSTRACT An applicator device for the application of hydrophobic compositions to hydrophilic surfaces. ) An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels 5 between the plurality of internal ridges.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier. Jammed oil-in-water emulsion toothpaste compositions with a hydrophobic phase with a particular droplet size of from about 0.4 microns to about 1000 microns, which can lead to toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Opaque jammed oil-in-water emulsion toothpaste compositions without an opacifier and/or abrasive. Toothpaste compositions including jammed oil-in-water emulsion wherein the opacity can be modified through physical manipulation. Toothpaste compositions comprising jammed oil-in-water emulsion wherein the toothpaste composition is opaque without a solid opacifier.

Kit compreendendo uma fonte de radiação eletromagnética e uma composição bucal multifásica semissólida compreendendo partículas hidrofílicas de agente de clareamento

kit compreendendo uma fonte de radiação eletromagnética e uma composição bucal multifásica semissólida compreendendo partículas hidrofílicas de agente de clareamento. a presente invenção se refere a um kit que compreende uma fonte de radiação eletromagnética e uma composição bucal multifásica semissólida sob a forma de uma dispersão para branqueamento dos dentes.

Composiciones para el cuidado bucal hidratantes que comprenden peroxido.

Composiciones para el cuidado bucal hidratantes que incluyen peróxido y agua. Composiciones dentífricas hidratantes que incluyen peróxido y agua. Composiciones para el cuidado bucal hidratantes que incluyen peróxido y agua que pueden liberar al menos aproximadamente 1 % del peróxido dentro de 120 segundos. Composiciones para el cuidado bucal hidratantes que incluyen peróxido y agua que pueden liberar al menos aproximadamente 15 % del peróxido dentro de 15 minutos.

Device for applying emulsion compositions

Composiciones para el cuidado bucal que comprenden peroxido y alumina.

Composiciones para el cuidado bucal que incluyen peróxido, alúmina y opcionalmente agua. Composiciones dentífricas que incluyen peróxido, alúmina y opcionalmente agua. Composiciones dentífricas que incluyen peróxido, alúmina calcinada y opcionalmente agua. Composiciones dentífricas que incluyen peróxido, alúmina calcinada, alúmina no calcinada y opcionalmente agua. Métodos de uso para blanquear los dientes usando una o más de las composiciones descritas.

Composição bucal multifásica semissólida que compreende partículas de agente ativo hidrofílico

composição bucal multifásica semissólida que compreende partículas de agente ativo hidrofílico. a presente invenção se refere a uma composição bucal multifásica semissólida sob a forma de uma dispersão semissólida para uso na cavidade bucal. as dispersões bucais semissólidas incluem partículas de agente ativo hidrofílico em fase hidrofóbica. as partículas de agente ativo hidrofílico podem incluir agentes alvejantes, agentes antimicrobianos, agentes anticálculo e/ou combinações dos mesmos.

Composição bucal semissólida de múltiplas fases compreendendo partículas de agente de clareamento hidrofílico

composição bucal semissólida de múltiplas fases compreendendo partículas de agente de clareamento hidrofílico. a presente invenção se refere a uma composição bucal semissólida de múltiplas fases sob a forma de uma dispersão para branqueamento dos dentes.

Producto blanqueador de dientes.

Un producto blanqueador de dientes comprende una composición bucal de fases múltiples contenida en un envase. La composición de fases múltiples comprende una fase hidrófoba que comprende un saborizante y una fase hidrófila que comprende un agente blanqueador de peróxido. El envase comprende un contenedor formado de un sustrato permeable al oxígeno que comprende una o más capas, en donde el sustrato tiene una velocidad de transmisión de oxígeno a 23 °C de al menos aproximadamente 5 cc/(m2*día) y el sustrato está libre de una capa de barrera. Un orificio dispensador en comunicación fluida con el contenedor está cubierto por una tapa.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values. Toothpaste compositions including jammed oil-in-water emulsion wherein the yield stress of the toothpaste composition can be modified through physical manipulation. Arrays of oral care compositions including a first jammed oil-in-water emulsion toothpaste composition including oral care active agent and a second oral care composition including peroxide.

Jammed emulsion toothpaste compositions comprising fluoride

Jammed oil-in-water emulsion toothpaste compositions. Anticavity jammed oil-in-water emulsion toothpaste compositions including fluoride. Anticavity jammed oil-in-water emulsion toothpaste compositions including an unexpectedly low amount of fluoride, such as less than 500 ppm of fluoride. An array of oral care compositions including a first anticavity jammed oil-in-water emulsion toothpaste including fluoride and a whitening composition, such as a second jammed oil-in- water emulsion toothpaste including peroxide.

Producto para el cuidado bucal.

Un producto para el cuidado bucal comprende un envase que comprende un recipiente y una punta aplicadora unida al recipiente. La punta aplicadora comprende un material que tiene una dureza Shore A de aproximadamente 15 a aproximadamente 80 y tiene un orificio dispensador en comunicación fluida con el recipiente. El orificio dispensador tiene un diámetro mínimo de al menos aproximadamente 0.5 mm, preferentemente al menos aproximadamente 1 mm. El producto para el cuidado bucal comprende además una composición para el cuidado bucal contenida dentro del recipiente del envase, en donde la composición para el cuidado bucal comprende un activo para el cuidado bucal y tiene un valor de penetración de cono de aproximadamente 10 a aproximadamente 500, preferentemente de aproximadamente 100 a aproximadamente 300.

Composiciones de pasta dental de emulsion espesada.

Composiciones de pasta dental de emulsión aceite en agua espesada. Composiciones de pasta dental de emulsión aceite en agua espesada con valores de límite de fluencia inesperadamente altos y/u opacidad alta sin el uso de un opacante sólido. Composiciones de pasta dental de emulsión aceite en agua espesada con una fase hidrófoba con un tamaño de gotita particular de aproximadamente 0.4 micrones a aproximadamente 1000 micrones, que pueden conducir a composiciones de pasta dental con valores de límite de fluencia inesperadamente altos y/u opacidad alta sin el uso de un opacante sólido.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier. Jammed oil-in-water emulsion toothpaste compositions with a hydrophobic phase with a particular droplet size of from about 0.4 microns to about 1000 microns, which can lead to toothpaste compositions with unexpectedly high yield stress values and/or high opacity without the use of a solid opacifier

Hydrating oral care compositions comprising peroxide

Hydrating oral care compositions including peroxide and water. Hydrating dentifrice compositions including peroxide and water. Hydrating oral care compositions including peroxide and water that can release at least about 1% of the peroxide within 120 seconds. Hydrating oral care compositions including peroxide and water that can release at least about 15% of the peroxide within 15 minutes.

Stain removing oral care compositions comprising medium length polyphosphates

Described herein are oral care compositions with improved stain removal performance without having to increase the amount of abrasive or incorporating oxidizing agents. For example, an oral care composition comprises: (a) about 20 % or greater, by weight of the oral care composition, of water; (b) a polyphosphate source comprising: (i) a first linear polyphosphate with an average chain length of from about 6 to about 21; (ii) a second linear polyphosphate with an average chain length of from about 2 to about 6, wherein the second linear polyphosphate has a smaller chain length than the first linear polyphosphate; (c) a pH of about 5 or less, and wherein the composition has a AE of about 3 or less.

Oral care product

An oral care product comprises a package comprising a container and an applicator tip attached to the container. The applicator tip comprises a material having a Shore A hardness of from about 15 to about 80 and has a dispensing orifice in fluid communication with the container. The dispensing orifice has a minimum diameter of at least about 0.5 mm, preferably at least about 1 mm. The oral care product further comprises an oral care composition contained within the container of the package, wherein the oral care composition comprises an oral care active and has a cone penetration value of from about 10 to about 500, preferably from about 100 to about 300.

Composiciones para el cuidado bucal que comprenden polifosfatos de longitud media.

Una composición para el cuidado bucal con uno o más polifosfatos con aproximadamente 20 % en peso o más de agua a un pH de aproximadamente 5 o menos. Una composición dentífrica con uno o más polifosfatos con aproximadamente 20 % en peso o más de agua a un pH de aproximadamente 5 o menos. Una composición de enjuague bucal con uno o más polifosfatos con aproximadamente 20 % en peso o más de agua a un pH de aproximadamente 5 o menos.

Device For Applying Emulsion Compositions

An applicator for the application of an oral care composition to an oral cavity. The applicator may include an applicator tip and an applicator handle detachably or non-detachably connected to a proximal end of the applicator tip. The applicator tip may include an external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges.

Semisolid Oral Dispersions Comprising Active Agents

A method for whitening teeth is provided where the method includes contacting at least one tooth surface with a semisolid oral dispersion. The semisolid oral dispersion may include solid hydrophilic active agent particles, where at least about 20 parts, by weight, of the solid hydrophilic active agent particles are soluble in about 100 parts, by weight, of water or the solid hydrophilic active agent particles swell by at least about 50% upon contact with water, and at least about 60%, by weight of the semisolid oral dispersion, of a semisolid hydrophobic phase.

Tooth whitening product

A tooth whitening product comprises a multi-phase oral composition contained in a package. The multi-phase composition comprises a hydrophobic phase comprising a flavor, and a hydrophilic phase comprising a peroxide bleaching agent. The package comprises a container formed of an oxygen-permeable substrate comprising one or more layers, wherein the substrate has an oxygen transmission rate at 23°C of at least about 5 cc/(m2*day) and the substrate is free of a barrier layer. A dispensing orifice in fluid communication with the container is covered by a cap.

Composiciones de pasta dental de emulsion espesada que comprenden fluoruro.

Composiciones de pasta dental de emulsión aceite en agua espesada. Composiciones de pasta dental de emulsión aceite en agua espesada anticaries que incluyen fluoruro. Composiciones de pasta dental de emulsión aceite en agua espesada anticaries que incluyen una cantidad inesperadamente baja de fluoruro, tal como menos de 500 ppm de fluoruro. Una matriz de composiciones para el cuidado bucal que incluyen una primera pasta dental de emulsión aceite en agua espesada anticaries que incluye fluoruro y una composición blanqueadora, tal como una segunda pasta dental de emulsión aceite en agua espesada que incluye peróxido.

Jammed emulsion toothpaste compositions comprising fluoride

Jammed oil-in-water emulsion toothpaste compositions. Anticavity jammed oil-in-water emulsion toothpaste compositions including fluoride. Anticavity jammed oil-in-water emulsion toothpaste compositions including an unexpectedly low amount of fluoride, such as less than 500 ppm of fluoride. An array of oral care compositions including a first anticavity jammed oil-in-water emulsion toothpaste including fluoride and a whitening composition, such as a second jammed oil-in- water emulsion toothpaste including peroxide.

Composiciones de pasta dental de emulsion espesada.

Composiciones de pasta dental de emulsión aceite en agua espesada. Composiciones de pasta dental de emulsión aceite en agua espesada con valores de límite de fluencia inesperadamente altos. Composiciones de pasta dental que incluyen emulsión aceite en agua espesada en donde el límite de fluencia de la composición de pasta dental puede modificarse mediante manipulación física. Matrices de composiciones para el cuidado bucal que incluyen una primera composición de pasta dental de emulsión aceite en agua espesada que incluye agente activo para el cuidado bucal y una segunda composición para el cuidado bucal que incluye peróxido.

Jammed emulsion toothpaste compositions

Jammed oil-in-water emulsion toothpaste compositions. Jammed oil-in-water emulsion toothpaste compositions with unexpectedly high yield stress values. Toothpaste compositions including jammed oil-in-water emulsion wherein the yield stress of the toothpaste composition can be modified through physical manipulation. Arrays of oral care compositions including a first jammed oil-in-water emulsion toothpaste composition including oral care active agent and a second oral care composition including peroxide.

Hydrating oral care compositions comprising peroxide

Oral care compositions comprising dicarboxylic acid

Oral care compositions including dicarboxylic acid and a pH of from about 4 to about 6. Oral care kits including a first oral care composition with fluoride and a second oral care composition with dicarboxylic acid. Oral care compositions including fluoride and dicarboxylic acid that provide an 5 erosion benefit, a stain prevention benefit, and/or a stain removal benefit.

Multi-phase oral care compositions

Semisolid oral dispersions for whitening teeth comprising a hydrophilic discontinuous phase and a hydrophobic continuous phase. The semisolid oral dispersions include a hydrophilic discontinuous phase comprising bleaching agent particles. The semisolid oral dispersions also include a hydrophobic continuous phase comprising petrolatum. The h bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Oral care compositions comprising medium length polyphosphates

An oral care composition with one or more polyphosphates with about 20 wt% or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt% or more of water at a pH of about 5 or less. A mouth rinse composition with one or more 5 polyphosphates with about 20 wt% or more of water at a pH of about 5 or less.