Gaszuführung für Elektrofilter und Elektrofiltervorrichtung

Improvements in and in the Method of Forming Blocks for Structural and Decorative Purposes.

... 12,293. Davis, T. May 24. Slabs.-Blocks for structural or decorative purposes are made by forming a sand bed a on a level floor b, marking out on the sand bed the structure to be formed, for instance the gable end of a house, laying on the sand rough stones g or other decorative or facing objects dividing the stones up into area i of a preferably slightly irregular shape by means of paper or tinfoil j, placing thin wooden strips k above the stones and substantially in line with the paper and finally running cement grouting m over the stones and completing the backing by means of rough finishing-cement n. After the cement backing is set, the blocks are marked for identification and removed for erection. The backing may be reinforced by metal hoops or rods.

TREATMENT PROCEDURE USING CTLA-4 ANTIBODIES

HYDROFINING

Methods of treatment using CTLA-4 antibodies

Methods of treatment using CTLA-4 antibodies

EMBEDDABLE MODULE FOR HIGH OUTPUT LED

In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. 144.-. (canceled)45. A light module , comprising:a housing providing a hollow chamber extending from a proximal end to a distal end,a lens positioned in the hollow chamber, the lens having a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens,an adapter configured for removable and replaceable coupling to the distal end of the hollow chamber of the housing, the adapter being further configured for receiving a proximal part of a light guide such that the light guide is secured within the adapter so as to receive at least a portion exiting the output surface of the lens, andwherein the adapter comprises an opening on a lateral surface thereof for receiving a retaining pin for securing the light guide within the adapter.46. The light module of claim 45 , wherein said adapter comprises a housing having a plurality of external threads for engaging with a plurality of internal threads disposed at an end of said hollow chamber for coupling the adapter to the hollow chamber.47. The light module of claim 46 , wherein said hollow chamber is substantially cylindrical.48. The light module of claim 45 , wherein said light guide comprises an optical fiber.49. The light module of claim 45 , wherein said light guide ...

Manure spreader.

An apparatus for dispersing material comprises a container for holding material to be dispersed, and a lid (38) movable relative to the base. A shaft (33) is rotatably mounted between the front and rear walls of the base and a plurality of dispersing members (19) are mounted on and rotatable with the shaft for throwing material held in the base through a gap (37) defined between the lid and the base. The shaft is movable in slot 28 in a substantially vertical direction to sustain generally uniform contact between the dispersing members and the material to be dispersed. ...

CARBOLIN DERIVATIVES FOR THE TREATMENT OF CANCER

PHOTO CHROME COMPOSITIONS AND ARTICLES WITH SILOXAN; ALKYLENODER SUBST. - ALKYLENOLIGOMEREN

TIGHTENER

SHOCK ABSORBER

Methods for treating viral conditions

Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are described. Also described are methods of inhibiting viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

PHOTO CHROME CONNECTIONS WITH POLYMERS SUBSTITUENTS, THEIR PRODUCTION AND USE

WATER DEMINERALIZATION PROCEDURE AND - DEVICE

Porous polymers

AIR COMPRESSOR MOTOR

POLYMERISATION REACTIONS UNDER MINIEMULSION CONDITIONS

A method of forming a polymer comprising: a) forming a miniemulsion including i) a monomer, ii) a non-aqueous solution including a cobalt-containing chain transfer agent, and iii) an aqueous solution; and b) reacting the miniemulsion in the presence of an initiator for a time sufficient to form the polymer.

Zusammensetzung zur Krebsbehandlung, welche ein antineoplastisches Mittel und einen PDE4-Inhibitor enthält

HYDRAULIC REFINING PROCESS FOR KOHLENWASSERSTOFFHALTIGES REPLACEMENT MATERIAL.

HYDROVISBREAKING FOR KOHLENWASSERSTOFFHALTIGES REPLACEMENT MATERIAL.

GASZUFÜHRUNG FOR ELECTROSTATIC FILTERS AND ELECTROSTATIC FILTER DEVICE

Gas supply for electrostatic filters and electrostatic filter arrangement

Ex-vivo rescue of transplantable hematopoietic stem cells following myeloablative injury

SYSTEM AND METHOD FOR FACILITATING HEMOSTASIS OF BLOOD VESSEL PUNCTURES WITH ABSORBABLE SPONGE

Trichter

Fork lift agricultural trailer

Trailer 1 has an elongate frame made up of longitudinal channels 2 and 3 and transverse members 6 and 6a. A fork-lift mast assembly 8 has a base portion including lateral members 10 carrying rollers 30 accommodated within the channels 2 and 3 so that the mast assembly may be displaced longitudinally along the length of the trailer between an extended position and a retracted position. In the extended condition, the forks 9 are located rearwardly of the frame so that they may be lowered to the ground, while in the retracted condition they are located inboard on the trailer frame, so that a load may be carried in a stable manner with its centre of gravity located between the wheels 5 and the coupling 7a. Hydraulic rams 24 and 23 control longitudinal displacement of the assembly and the raising and lowering movement of the forks 9 respectively. The upwardly-extending part of the mast may also be tilted relative to the base portion by further hydraulic rams 24. ...

Methods of treatement using CTLA-4 antibodies

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

VERFAHREN ZUR HYDROFINING-BEHANDLUNG EINES KOHLENWASSERSTOFFHALTIGEN BESCHICKUNGSSTROMS

ABGASDÜSENKÜHLSYSTEM

ZIGARETTENHERSTELLUNGSMASCHINE UND STEUERSYSTEM DAFÜR

Improvements in Rotary Engines.

... 18,331. Davis, T. Sept. 11. Crescent - shaped chamber type.-In steam or compressed-air engines of the e crescentshaped chamber type having hinged vanes pressed outwardly by springs, a part J of the casing is made concentric with the shaft E. The piston D carries three hinged vanes C pressed outwards by tangentiallyarranged spring- pressed plungers K. The inlet port is shown at B and the exhaust port at F, the latter opening as the former is closed.

HYDROFINING PROCESS FOR HYDROCARBON CONTAINING FEED STREAMS

At least one decomposable molybdenum dithiocarbamate compound is mixed with a hydrocarbon-containing feed stream. The hydrocarboncontaining feed stream containing such decomposable molybdenum dithiocarbamate compound is then contacted in a hydrofining process with a catalyst composition comprising a support selected from the group consisting of alumina, silica and silica-alumina and a promoter comprising at least one metal selected from Group VIB, Group VIIB and Group VIII of the Periodic Table. The introduction of the decomposable molybdenum dithiocarbamate compound may be commenced when the catalyst is new, partially deactivated or spent with a beneficial result occuring in each case.

New or Improved Compartmented and Separable Envelope for the Transmission of Subscriptions, Donations, and the like.

... 118,263. Davis, T. June 14, 1918. Envelopes.-In an envelope of the kind formed with several compartments a, b, c disposed side by side, a single closing flap 4 is provided for all the compartments, and the usual lines of perforations 7 are continued across this flap so that the closed .envelope may easily be torn into complete closed units.

Pipe Cleaner.

... 103,284. Davis, T. Nov. 25, 1916. Cleaning internally, non-rotary appliances for.-A cleaner or scraper consists of two or more helically coiled coreless strips 1, 2 flexibly connected, preferably by means cf links 3, and adapted to be drawn through the water-main or other pipe by means of a cable 5. In the construction shown, two strips coiled in opposite directions are employed.

KREBSBEHANDLUNG ZUSAMMENSETZUNG, WELCHE EIN ANTINEOPLASTISCHES MITTEL UND PDE4 INHIBITOR ENTHÄLT

Gas supply for electrostatic filters and electrostatic filter arrangement

HYDROVISBREAKING PROCESS FOR HYDROCARBON CONTAINING FEED STREAMS

At least one decomposable molybdenum compound selected from the group consisting of molybdenum dithiophosphates and molybdenum dithiocarbamates is mixed with a hydrocarbon-containing feed stream. The hydrocarbon-containing feed stream containing such decomposable molybdenum compound is then contacted in a hydrovisbreaking process with hydrogen under suitable hydrovisbreaking conditions.

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

... ²Compounds that selectively inhibit pathological production of human vascular ²endothelial growth factor (VEGF) and compositions comprising such compounds ²are ²described. Compounds that inhibit viral replication or the production of viral ²RNA or DNA ²or viral protein and compositions comprising such compounds are described. ²Also described ²are methods of reducing VEGF using such compounds and methods for treating ²cancer and ²non-neoplastic conditions involving the administration of such compounds. ²Further described ²are methods of inhibiting viral replication or the production of viral RNA or ²DNA or viral ²protein using such compounds and methods for treating viral infections ²involving the ²administration of such compounds. The compounds may be administered as a ²single agent ²therapy or in combination with one or more additional therapies to a human in ²need of such ²treatments.² ...

HYDROVISBREAKING

NANOPARTICLE ENCAPSULATION TO TARGET G PROTEIN-COUPLED RECEPTORS IN ENDOSOMES

The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder.

HYDROFINING PROCESS FOR HYDROCARBON CONTAINING FEED STREAMS

At least one decomposable molybdenum dithiophosphate compound is mixed with a hydrocarbon-containing feed stream. The hydrocarboncontaining feed stream containing such decomposable molybdenum dithiophosphate compound is then contacted in a hydrofining process with a catalyst composition comprising a support selected from the group consisting of alumina, silica and silica-alumina and a promoter comprising at least one metal selected from Group VIB, Group VIIB and Group VIII of the Periodic Table. The introduction of the decomposable molybdenum dithiophosphate compound may be commenced when the catalyst is new, partially deactivated or spent with a beneficial result occurring in each case.

ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES

In accordance with the present invention, compounds are provided which ar e useful in a method or in the manufacture of a medicament for post-transcri ptionally inhibiting the expression of VEGF in a subject in need thereof com prising inhibiting VEGF mRNA translation by orally administering said medica ment once, twice or thrice daily to the subject.

METHODS OF TREATEMENT USING CTLA-4 ANTIBODIES

The present invention provided method of treatment using human sequence antibodies against human CTLA-4. in particular, methods of treating cancer are provided. © KIPO & WIPO 2007 ...

METHODS OF TREATEMENT USING CTLA-4 ANTIBODIES

Method for facilitating blood vessel hemostasis

HYDROFINING

Improvements in or relating to gas-cooled nuclear reactors

... 789,257. Nuclear fuel elements. UNITED KINGDOM ATOMIC ENERGY AUTHORITY. Oct. 25, 1956 [Nov. 5, 1955], No. 31697/55. Class 39(4). A nuclear fuel element comprises a rod or tube of fissile material 10, 23, undulating in longitudinal section, and enclosed in a sheath 11 of substantially uniform thickness. In form the undulations of the element may be sinuous, as with the tube shown in Fig. 2, or angular as produced by annuli 18 of Fig. 1. Conical members 15, 14 screwed to end caps 12 locate the element. Rings 21 introduce turbulence. The sheaths 24, 25 of the tubular element may be roughened to promote heat transfer. The coolant channel 16 shown is in a graphite structure 22 and in Fig. 1 a gaseous coolant may be circulated downwards to reduce resistance to flow, or preferably upwards to improve heat transfer.

HYDROFINING

Administration of carboline derivatives useful in the treatment of cancer and other diseases

Electrostatic fast-set sprayable polymer system and process

A method and apparatus for electrostatically spraying a plural component fast set polymer is disclosed. The system comprises a spray gun and at least two hoses connected to the head of the spray gun. The system also includes a proportioner connected to an end of the at least two hoses and a high voltage generator electrically and pneumatically in communication with the spray gun. The electrostatic spray system will allow for a fast set polymer to be imparted with electrical charge after mixing of a first and second component in a spray head thereof prior to expulsion via a nozzle to a grounded target that is being coated with the electrostatic spray coating.

Method and apparatus for rapid surveying of static structures

An apparatus to facilitate field assessment of static structure sites to provide data in a predetermined format acceptable to a taxing authority, including a personal computing device having a graphic display screen, a user interface, and application software. The user interface is arranged to accept alphanumeric data provided by a user of the apparatus and also accept graphic input from the user representative of structural features of the static structure. The application software is arranged to provide a real-time display on the graphic display screen of dimensional data associated with the graphic inputs as they are entered by the user. The application software is also arranged to compute dimensional attributes of enclosed polygons resulting from the graphic input by the user.

Embeddable Module For High Output LED

In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing. In other embodiments, the shoulder can be provided by a sleeve disposed in the module's housing. 1. A light module , comprising:a housing providing a hollow chamber extending from a proximal end to a distal end,a lens positioned in said hollow chamber, said lens having a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens, said lens further comprising a collar encircling at least partially said lens body,at least one shoulder disposed in said hollow chamber in contact with said collar for providing mechanical support to said lens,a light source coupled to said hollow chamber at said proximal end for providing light to said input surface of the lens.2. The light module of claim 1 , further comprising an optical window disposed in said hollow chamber and optically coupled to said output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light ...

HYDROVISBREAKING

Polymerisation reactions under miniemulsion conditions

HYDROFINING

Nanoparticle encapsulation to target G protein-coupled receptors in endosomes

The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder.

POLYESTERS CONTAINING COPOLYMERIZED, ANTHRAQUINONE COLORANT COMPOUNDS CONTAINING SULFONAMIDO GROUPS

POLYMERISATION REACTIONS UNDER MINIEMULSION CONDITIONS

A method of forming a polymer comprising: a) forming a miniemulsion including i) a monomer, ii) a non-aqueous solution including a cobalt- containing chain transfer agent, and iii) an aqueous solution; and b) reacting the miniemulsion in the presence of an initiator for a time sufficient to form the polymer. © KIPO & WIPO 2007 ...

BMI-1 PROTEIN EXPRESSION MODULATORS

The compounds, pharmaceutical compositions, and methods of using such compounds or compositions thereof described herein are useful for treating a disease modulated by B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein expression.

HYDROVISBREAKING-VERFAHREN FUER KOHLENWASSERSTOFFHALTIGE SPEISESTROEME

ZIGARETTENHERSTELLUNGSMASCHINE UND STEUERSYSTEM DAFÜR

Sprayed in place pipe lining apparatus and method thereof

A method and apparatus for applying a liner to a pipe is disclosed. The apparatus includes a base assembly having a plurality of guide rails and a shuttle plate attached thereto. The apparatus also includes a motor module attached to an end of the base assembly. An extension arm is connected to a top surface of the shuttle plate. The extension arm has a spray head assembly attached at an opposite end thereof. The extension arm and spray head assembly will move relative to the base assembly of the apparatus. A fast cure coating will be applied via the spray head assembly to the interior surface of a pipe being rehabilitated. The spray head assembly will have an air blow off mechanism therein thus allowing for the tip of the spray head assembly to stay relatively clog free during the fast cure coating operation of the apparatus. The methodology also includes an oscillation system wherein the spray head assembly will move relative to the base assembly thus creating an over lapping pattern ...

Methods for treating cancer and non-neoplastic conditions

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

Trichter

Administration of Carboline Derivatives Useful in the Treatment of Cancer and Other Diseases

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Methods for screening for compounds for treating cancer

The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.

Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment

This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

HYDROFINING PROCESS FOR HYDROCARBON CONTAINING FEED STREAMS

Carboline derivatives useful in the treatment of cancer

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

USE OF ANTI-PD-1 ANTIBODY IN COMBINATION WITH ANTI-CD27 ANTIBODY IN CANCER TREATMENT

This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof. 1. A method for treating a subject afflicted with a tumor comprising administering the subject in need thereofan antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“anti-PD-1 antibody or antigen-binding portion thereof”) in combination withan antibody or an antigen-binding portion thereof that specifically binds to CD27 (“anti-CD27 antibody or antigen-binding portion thereof”).2. The method of claim 1 , wherein the tumor is colorectal cancer claim 1 , rectal cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , melanoma claim 1 , ovarian cancer claim 1 , head and neck cancer claim 1 , or any combination thereof.3. The method of claim 2 , wherein the lung cancer is non-small cell lung cancer (NSCLC).4. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof cross-competes with nivolumab for binding to human PD-1.5. The method of claim 1 , wherein the anti-CD27 antibody or antigen-binding portion thereof cross-competes with varlilumab for binding to human CD27.6. The method of claim 1 , wherein:(i) the anti-PD-1 antibody is nivolumab;(ii) the anti-CD27 antibody is varlilumab; or(iii) the anti-PD-1 antibody is nivolumab and the anti-CD27 antibody is varlilumab.7. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose ranging from at least about 0.1 mg/kg to at least about 10.0 mg/kg body weight once about every 1 claim 1 , 2 or 3 weeks.8. The method of claim 7 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose of at ...

ABGASDÜSENKÜHLSYSTEM

Gas supply for electrostatic filter and electrostatic filter arrangement

Gas supply for electrostatic filter and electrostatic filter arrangement

The invention relates to a gas supply for an electrostatic filter and an electrostatic filter arrangement which has an electrostatic filter and gas supply. Here, the gas supply has an incoming flow channel of constant cross-sectional area, a gas inlet hood with cross-sectional area expanding in the direction of the electrostatic filter, and an admixture arrangement for a conditioning means, wherein at least one flow distributor is arranged in the expanded cross-sectional region of the gas inlet hood. Characterizing features include a first vortex arrangement generating a leading-edge vortex arranged in the incoming flow channel, a second vortex arrangement generating a leading-edge vortex arranged in the gas inlet hood before the flow divider in the gas flow direction, and the admixture arrangement arranged in the region of one of the two vortex arrangements.

Carboline derivatives useful in the treatment of cancer

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

HYDROVISBREAKING PROCESS FOR HYDROCARBON CONTAINING FEED STREAMS

GAS SUPPLY FOR ELECTROSTATIC FILTER, AND ELECTROSTATIC FILTER ARRANGEMENT HAVING ELECTROSTATIC FILTER AND GAS SUPPLY WITHIN

PURPOSE: A gas supply for electrostatic filter and an electrostatic filter arrangement are provided to improve the efficiency of an electrostatic filter device. CONSTITUTION: The electrostatic filter device(1) includes: an electrostatic filter(2); a gas supply(3); and a gas exhauster(4). The gas supply(3) carries a gas flow(5) and filtrates it, and the electrostatic filter(2) deflects the gas flow(5) form a vertical direction to a basic, horizontal direction. The gas flow(5) filtrated by the filter(2) is discharged through the gas exhauster(4) as a other gas flow(6) which is filtrated by the electrostatic filter device(1) and frees the particles within the gas collected through the pre-treated electric processes. The gas supply(3) basically comprises a vertical inflow channel(6) on its' own constant flow section. © KIPO 2006 ...

Electrolytic capacitor case design with insert molded elastomer seals

Disclosed herein is a method for manufacturing a feed thru for use in an electrolytic capacitor case. First, an electrode is inserted into a liquid injection mold. Liquid elastomer is then injected into the mold to surround a portion of the electrode. The elastomer is cured, and the resulting electrode and feed thru combination is inserted into a machined hole in a capacitor case. The machined hole may be located on either the base or the lid of the capacitor case. In other embodiments, a ferrule may also be placed in the liquid injection mold prior to injecting liquid elastomer. When a ferrule is used, the assembly may be welded into a machined hole in a capacitor case.

Handheld mobile light source

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Methods for treating cancer and non-neoplastic conditions

BMI-1 protein expression modulators

Compounds having Formula I: wherein the variables Ar1, Ar2, R1, R2 and R3 are defined herein, pharmaceutical compositions, and methods of using such compounds or compositions for inhibiting Bmi-1 expression.

Handheld mobile light source

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

GAS SUPPLY FOR ELECTROSTATIC FILTER AND ELECTROSTATIC FILTER ARRANGEMENT

The invention relates to a gas supply for an electrostatic filter and an electrostatic filter arrangement which has an electrostatic filter and a gas supply. Here, the gas supply has an incoming flow channel of constant cross-sectional area, a gas inlet hood with cross-sectional area expanding in the direction of the electrostatic filter, and an admixture arrangement for a conditioning means, wherein at least one flow distributor is arranged in the expanded cross-sectional region of the gas inlet hood. Characterizing features include a first vortex arrangement generating a leading-edge vortex arranged in the incoming flow channel, a second vortex arrangement generating a leading-edge vortex arranged in the gas inlet hood before the flow divider in the gas flow direction, and the admixture arrangement arranged in the region of one of the two vortex arrangements.

ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES

In accordance with the present invention, compounds are provided which are useful in a method or in the manufacture of a medicament for post-transcriptionally inhibiting the expression of VEGF in a subject in need thereof comprising inhibiting VEGF mRNA translation by orally administering said medicament once, twice or thrice daily to the subject.

HANDHELD MOBILE LIGHT SOURCE

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment

This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

METHODS FOR SCREENING FOR COMPOUNDS FOR TREATING CANCER

The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.

CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. 118.-. (canceled)22. The method of any one of to , wherein said stereoisomer of said compound is an (S) isomer at said chiral carbon.23. The method of any one of to , wherein inhibiting pathologically induced VEGF expression treats a solid tumor cancer.24. The method of any one of to , wherein the compound has an ECof less than 50 μM for inhibiting hypoxia-induced VEGF expression in cultured HeLa cells.25. The method of claim 19 , wherein the compound inhibits pathologically induced VEGF production in a HT1080 solid tumor grown in a nude mouse.26. The method of claim 19 , wherein the compound inhibits HT1080 solid tumor growth in a nude mouse.27. The method of claim 19 , wherein the compound inhibits angiogenesis in a HT1080 solid tumor grown in a nude mouse.28. The method of claim 19 , wherein the compound inhibits pathologically induced VEGF production as shown by an ELISA in HeLa cells. This application is a divisional of U.S. application Ser. No. 11/735,069, filed Apr. 13, 2007, which is a continuation-in-part of U.S. application Ser. No. 11/107,783, filed Apr. 18, 2005, which is a continuation-in-part of U.S. application Ser. No. 11/079,420, filed Mar. 15, 2005, and having the title “Carboline Derivatives Useful in the Inhibition of Angiogenesis,” which claims the benefit of and priority to U.S. Provisional Application No. 60/552,725, ...

Gas supply for electrostatic filter and electrostatic filter arrangement

The invention relates to a gas supply for an electrostatic filter and an electrostatic filter arrangement which has an electrostatic filter and a gas supply. Here, the gas supply has an incoming flow channel of constant cross-sectional area, a gas inlet hood with cross-sectional area expanding in the direction of the electrostatic filter, and an admixture arrangement for a conditioning means, wherein at least one flow distributor is arranged in the expanded cross-sectional region of the gas inlet hood. Characterizing features include a first vortex arrangement generating a leading-edge vortex arranged in the incoming flow channel, a second vortex arrangement generating a leading-edge vortex arranged in the gas inlet hood before the flow divider in the gas flow direction, and the admixture arrangement arranged in the region of one of the two vortex arrangements.

Method and apparatus for determining the identity of a digital printer from its output

A method for inserting an identification modulation code into a printed image. The method has the steps of inserting a start code modulation sequence, followed by the code modulation sequence, and then a stop code modulation sequence. The code is preferably repeated several times throughout the printed image. The modulation sequence can have several levels of subpixel modulation magnitude.

Layered neutron shielding

Neutron shielding. The neutron shielding comprises a plurality of absorption layers, and at least one moderating layer. The plurality of absorption layers each comprise tungsten boride or tungsten carbide. The at least one moderating layer comprises a metal hydride. Each moderating layer is between at least two absorption layers.

USE OF ANTI-PD-1 ANTIBODY IN COMBINATION WITH ANTI-CD27 ANTIBODY IN CANCER TREATMENT

This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof. 1. A method for treating a subject afflicted with a tumor comprising administering the subject in need thereofan antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“anti-PD-1 antibody or antigen-binding portion thereof”) in combination withan antibody or an antigen-binding portion thereof that specifically binds to CD27 (“anti-CD27 antibody or antigen-binding portion thereof”).2. The method of claim 1 , wherein the tumor is colorectal cancer claim 1 , rectal cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , melanoma claim 1 , ovarian cancer claim 1 , head and neck cancer claim 1 , or any combination thereof.3. The method of claim 2 , wherein the lung cancer is non-small cell lung cancer (NSCLC).4. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof cross-competes with nivolumab for binding to human PD-1.5. The method of claim 1 , wherein the anti-CD27 antibody or antigen-binding portion thereof cross-competes with varlilumab for binding to human CD27.6. The method of claim 1 , wherein:(i) the anti-PD-1 antibody is nivolumab;(ii) the anti-CD27 antibody is varlilumab; or(iii) the anti-PD-1 antibody is nivolumab and the anti-CD27 antibody is varlilumab.7. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose ranging from at least about 0.1 mg/kg to at least about 10.0 mg/kg body weight once about every 1 claim 1 , 2 or 3 weeks.8. The method of claim 7 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose of at ...

GAS SUPPLY FOR ELECTROSTATIC PRECIPITATOR AND ELECTROSTATIC PRECIPITATOR

Methods for treating cancer and non-neoplastic conditions

Method of spray a liner on the inside surface of a pipe

A method for applying a liner to a pipe is disclosed. The methodology includes inserting an apparatus within the pipe and moving the apparatus at a predetermined speed through the pipe. The method sprays a material from a spray head secured to the apparatus. The methodology also includes an oscillation system wherein the spray head assembly will move relative to the base assembly thus creating an over lapping pattern for the spray coating being applied to the interior surface of the pipeline. This oscillation system will allow for a more uniform coating to be applied.

Electrostatic fast-set sprayable polymer system and process

A method and apparatus for electrostatically spraying a plural component fast set polymer is disclosed. The system comprises a spray gun and at least two hoses connected to the head of the spray gun. The system also includes a proportioner connected to an end of the at least two hoses and a high voltage generator electrically and pneumatically in communication with the spray gun. The electrostatic spray system will allow for a fast set polymer to be imparted with electrical charge after mixing of a first and second component in a spray head thereof prior to expulsion via a nozzle to a grounded target that is being coated with the electrostatic spray coating.

Carboline derivatives useful in the inhibition of angiogenesis

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Methods for treating cancer and non-neoplastic conditions

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

Photovoltaic-Thermal (PV-T) System for Desalination

A photovoltaic-thermal (PV-T) system and a method of cooling photovoltaic (PV) cells in the system is described herein. Energy from an excitation source such as the sun hits the PV cells in the PV-T system causing heating that reduces PV efficiency. The PV cells are cooled by fluid in an intact heat-transfer system making a heated water byproduct while the PV cells release a form of energy. In addition, the PV-T system can be implemented in a desalination plant to harvest energy and heat for desalination processes. The present invention also includes methods for transferring heat from PV cells to the earth to improve PV performance and reduce thermal shock to the PV cells. 1. A photovoltaic-thermal (PV-T) based desalination system , wherein the PV-T desalination system comprises:one or more arrays of photovoltaic (PV) cells in thermal communication with an excitation source;a cooling system in contact with the PV-T system, wherein a fluid that traverses the cooling system cools the PV cells and makes a heated water byproduct; anda desalination system for capturing and using a thermal energy from the heated water byproduct.2. The system of claim 1 , wherein the desalination system comprises a reverse osmosis (RO) claim 1 , nanofiltration (NF) claim 1 , electrodialysis (ED) claim 1 , electrodialysis reversal (EDR) claim 1 , electrodeionization (EDI) claim 1 , capacitive deionization (CDI) claim 1 , membrane distillation (MD) claim 1 , evaporative desalination processes claim 1 , or any combinations thereof.3. The system of claim 1 , wherein one or more lenses or mirrors are used to intensify the thermal communication with the excitation source to harvest a form of energy.4. A method of cooling one or more photovoltaic (PV) cells in a photovoltaic-thermal (PV-T) based desalination system claim 1 , comprising the steps of:disposing a cooling system on, at, or about the one or more PV cells, wherein a fluid that traverses the cooling system cools the PV cells to produce ...

METHODS FOR TREATING NEUROFIBROMATOSIS

Methods for treating neurofibromatosis involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. 2. The method of claim 1 , wherein the NF is NF Type 1.3. The method of claim 1 , wherein the NF is NF Type 2.4. The method of claim 3 , wherein bilateral vestibular schwannomas or unilateral vestibular schwannomas are present in the human in optional conjunction with the presence of one or more NF2-associated tumors selected from a meningioma claim 3 , schwannoma claim 3 , ependymoma claim 3 , glioma or neurofibroma.5. The method of claim 1 , wherein the NF is Schwannomatosis.6. The method of claim 1 , wherein the effective amount is in a range of from about 0.001 mg per kg per day to about 1500 mg per kg per day.7. The method of claim 1 , wherein the compound is administered during or within about 30 minutes after a meal.8. The method of claim 1 , wherein the effective amount of the compound is administered two times per day at a time interval of from about 12 hours to about 18 hours between doses.9. The method of claim 8 , wherein the effective amount of the compound is administered two times per day at a time interval of about 12 hours between doses.10. The method of claim 1 , wherein the effective amount of the compound is administered three times per day at a time interval of from about 8 hours to about 12 hours between doses.11. The method of claim 10 , wherein the effective amount of the compound is administered three times per day at a time interval of about 8 hours between doses. This application claims the benefit of priority to U.S. Provisional Patent Application 61/181,650, filed May 27, 2009, incorporated herein by reference in its entirety and for all purposes.Methods for treating neurofibromatosis involving the administration of a compound ...

METHODS FOR TREATING BRAIN TUMORS

Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment. 2. The method of claim 1 , wherein the brain tumor is a malignant primary brain tumor claim 1 , a malignant non-primary brain tumor claim 1 , a benign primary brain tumor or a benign non-primary brain tumor.3. The method of claim 2 , wherein the primary brain tumor is a glioma or non-glioma claim 2 , wherein the glioma is selected from an astrocytoma claim 2 , an oligodendroglioma claim 2 , a mixture of oligodendroglioma and astrocytoma elements or an ependymoma claim 2 , and wherein the non-glioma is selected from a non-malignant meningioma or pituitary adenoma or a malignant primitive neuroectodermal tumor claim 2 , medullblastoma claim 2 , primary Central Nervous System (CNS) lymphoma or CNS germ cell tumor.4. The method of claim 2 , wherein the brain tumor is an acoustic neuroma claim 2 , an anaplastic astrocytoma claim 2 , glioblastoma multiforme claim 2 , a meningioma claim 2 , a brain stem glioma claim 2 , a craniopharyngioma claim 2 , an ependyoma claim 2 , a juvenile pilocytic astrocytoma claim 2 , a medulloblastoma claim 2 , an optic nerve glioma claim 2 , a primitive neuroectodermal tumor or a rhabdoid tumor.5. The method of claim 4 , wherein the brain tumor is glioblastoma multiforme.6. The method of claim 1 , wherein the brain tumor is in a human adult.7. The method of claim 1 , wherein the brain tumor is in a human child.8. The method of claim 1 , wherein the effective amount of the compound is administered based on body weight.9. The method of claim 1 , wherein the effective amount is in a range of from about 0.001 mg per kg per day to about 1500 mg per kg per day.10. The method of claim 1 , wherein the compound is administered during or within ...

HYBRID OPEN-LOOP/CLOSED-LOOP COMPRESSION OF PICTURES

In a method of video coding, in which a difference is formed between input picture values and picture prediction values and that difference is transforming with a DCT, the picture prediction is formed as: P=(1−c)P+CPwhere Pis a closed loop predictor which is restricted to prediction values capable of exact reconstruction in a downstream decoder and Pis a spatial predictor which is not restricted to prediction values capable of exact reconstruction. The factor can vary from zero to unity depending on a variety of parameters. 1. A method of compression coding , the method comprising the steps of:forming a difference between input picture values and picture prediction values; and transforming the difference in a transform;{'sup': C', 'O', 'O', 'O, 'wherein a picture prediction P is formed by the combination of a predictor Pwhich is a temporal predictor or a spatial predictor and which is restricted to prediction values capable of exact reconstruction in a downstream decoder and a predictor Pwhich is not restricted to prediction values capable of exact reconstruction in a downstream decoder, the predictor Pbeing a spatial predictor with the transform being a spatial transform or a temporal transform or the predictor Pbeing a temporal predictor with the transform being a temporal transform.'}2. A method according to claim 1 , wherein said picture prediction P comprises a weighted sum of the respective outputs of the predictor Pand the predictor Pof the form:{'br': None, 'i': P=aP', '+bP, 'sup': C', 'O}3. A method according to claim 1 , wherein the relative weighting of the predictor Pand the predictor Pvaries with picture content.4. A method according to claim 1 , wherein the picture prediction P is formed as:{'br': None, 'i': P', '−c', 'P', '+cP, 'sup': C', 'O, '=(1)'}where c is a selectable weighting factor variable between zero and unity.5. A method according to claim 4 , wherein metadata indicating the weighting factor c is signalled in a bitstream.6. A method ...

METHODS FOR TREATING PROSTRATE CONDITIONS

Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described. Methods for treating benign prostatic hyperplasia involving the administration of a compound that selectively inhibits pathological production of human VEGF are also described. The compound may be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. 2. (canceled)3. The method of claim 1 , wherein the prostate cancer is castration-resistant prostate cancer.4. The method of claim 1 , wherein the effective amount is in a range of from about 0.001 mg per kg per day to about 1500 mg per kg per day.5. The method of claim 1 , wherein the compound is administered during or within about 30 minutes after a meal.6. The method of claim 1 , wherein the effective amount of the compound is administered two times per day at a time interval of from about 12 hours to about 18 hours between doses.7. The method of claim 1 , wherein the effective amount of the compound is administered two times per day at a time interval of about 12 hours between doses.8. The method of claim 1 , wherein the effective amount of the compound is administered three times per day at a time interval of from about 8 hours to about 12 hours between doses.9. The method of claim 1 , wherein the effective amount of the compound is administered three times per day at a time interval of about 8 hours between doses.11. (canceled)13. (canceled)15. (canceled)17. (canceled)19. (canceled)21. (canceled) This application claims the benefit of priority to U.S. Provisional Patent Application 61/181,649, filed May 27, 2009, incorporated herein by reference in its entirety and for all purposes.Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial ...

Low friction wheel for toy cars

A wheel for toy cars with a threaded bore. The threaded bore provides a low friction surface between the wheel and axel, and enables a custom fit to axel through thread deformation. 1. A low friction wheel for toy cars comprising:A threaded wheel bore, hub, rim, and tread.2. The threaded wheel bore of wherein the threads are continuous through the wheel bore; the wheel bore is of equal diameter throughout its length.3. The threaded wheel bore of wherein the wheel bore threads are suggested to be of typical machine threads.4. The threaded wheel bore of wherein the wheel bore diameter is suggested to be slightly smaller than the wheel axel to allow for a custom fit between the threaded wheel bore and axel. A custom fit between the axel and threaded wheel bore is achieved by inserting the axel into the wheel bore claim 1 , and rotating the wheel on the axel. Application of pressure on the wheel perpendicular to the axel during wheel rotation will burnish the threads providing necessary clearance between the wheel bore and axel.5. The threaded wheel bore of wherein the wheel bore thread diameter may be burnished claim 1 , and or reamed to increase the wheel bored diameter.6. The hub of wherein may have a chamfered or rounded edge to minimize surface contact with the car body to reduce friction.7. The rim of wherein a design of the rim may include decorative designs such as a wheel hub cap claim 1 , tire claim 1 , tire tread claim 1 , numbers claim 1 , letters or designs for appearance purposes.8. The tread of wherein the design of the tread may be smooth claim 1 , grooved claim 1 , or otherwise configured to reduce friction.9. The tread of wherein the tread may be decorative in nature.10. The tread of wherein the tread mass is reduced to minimize energy needed to rotate the wheel.11. The threaded wheel bore of wherein the threaded wheel bore; hub claim 1 , rim claim 1 , and tread are symmetrical in design or consistent in shape to allow the wheel to remain in balance ...

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. 2. A pharmaceutical composition comprising the compound of .5. The method of claim 3 , wherein the cell is in a subject.6. The method of claim 4 , wherein in the cell is in a subject.13. A method for treating cancer in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .14. A method for treating a non-neoplastic condition in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .15. A method for treating a viral infection in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .16. The method of claim 13 , wherein the cancer is a solid tumor cancer.17. (canceled)18. The method of claim 14 , wherein the non-neoplastic condition is rheumatoid arthritis claim 14 , obesity claim 14 , psoriasis claim 14 , atherosclerosis claim 14 , diabetic retinopathy claim 14 , retinopathy of prematurity claim 14 , retrolental fibroplasia claim 14 , neovascular glaucoma claim 14 , age-related macular degeneration claim 14 , exudative macular ...

SYSTEM AND METHOD OF DEPICTING FOLIAGE

A system and method for creating and replicating foliage patterns comprising: a first stencil, where the first stencil forms the shape of a leaf; and a second stencil, where the second stencil forms the shape of an arrangement of veins and stems of a leaf, wherein a user may selectively arrange and attach the first and second stencil to create a foliage pattern. The leaf may include either an oak leaf or a maple leaf. The user may selectively apply at least one paint color to the stencils to create a depiction of the foliage pattern. In one particular embodiment, the system may comprise a layer of clear coat paint or sealant over the painted surface in order to protect the appearance of the pattern of foliage. 1. A system for creating and replicating foliage patterns comprising:a. a first stencil, where the first stencil forms the shape of a leaf; andb. a second stencil, where the second stencil forms the shape of an arrangement of veins and stems of a leaf, wherein a user may selectively arrange and attach the first and second stencil to create a foliage pattern.2. The system according to claim 1 , where the leaf includes at least one of an oak leaf and a maple leaf.3. The system according to claim 1 , where the user selectively applies at least one paint color to the stencils to create a depiction of the foliage pattern.4. The system according to claim 1 , further comprising a layer of clear coat paint or sealant over the painted surface in order to protect the appearance of the pattern of foliage.5. The system according to claim 3 , where the user applies the paint with an airbrush.6. The system according to claim 3 , where the user applies the paint with at least one of a horsehair brush claim 3 , a synthetic hair brush and an aerosol spray.7. The system according to claim 1 , where the foliage pattern includes an appearance of depth.8. A method of creating and replicating foliage patterns comprising the steps of:a. forming a stencil arrangement with a first ...

CRYPTIC GLYCAN MARKERS AND APPLICATIONS THEREOF

The present invention relates to a novel glycan marker of cancer and monoclonal antibodies against it. Furthermore, novel glycan markers and their use in the detection and monitoring of cancerous cells and cancer-associated or specific antibody signatures are described. 1. A glyco-epitope that is aberrantly expressed by tumor cells , including human melanoma (Trombelli , MM5) , prostate (PC3 , DU145 , LN-CAP) , breast (ZR75.1 , MDA-MB 468) , and ovarian cancer cell lines (PEA-1 , PEO-1 , SK-OV-3) and that is displayed by mannose-containing N-glycans of tumor cells and by high-mannose-cluster-carrier protein conjugates in carbohydrate microarrays.2. An antibody that specifically binds to the glyco-epitope of .3. The antibody of claim 2 , wherein said antibody is a mouse monoclonal claim 2 , mouse-human chimeric or humanized antibody claim 2 , or a functional fragment thereof.4. The antibody of claim 3 , that is an IgM antibody.5. The antibody of claim 3 , that is an IgG antibody.6. Monoclonal antibody TM 10 that specifically binds to the glyco-epitope of and that is produced by the hybridoma cell line TM10 and deposited with the ATCC on ______.7. Functional fragments of the monoclonal antibody of claim 6 , wherein the binding portion is selected from the group consisting of an Fab claim 6 , an F(ab′)2 fragment and an Fv fragment.8. The antibody of wherein the antibody is conjugated to a label that produces a detectable signal.9. The antibody of claim 8 , wherein the label is selected from the group consisting of a radiolabel claim 8 , an enzyme claim 8 , a chromophore and a fluorescer.10. Hybridoma cell line TM10 claim 8 , as deposited with the ATCC on ______.11. A method to detect cancerous cells or a portion thereof in a biological sample comprising: providing an antibody or binding portion thereof which recognizes the glyco-epitope of claim 8 , wherein the antibody is selected from claim 8 , claim 8 , or claim 8 , and wherein the antibody or binding portion ...

Methods for treating viral conditions

Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are described. Also described are methods of inhibiting viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

PICTURE CODING AND DECODING

An image encoder utilising a transformation operating between a spatial domain and a DCT or other transform domain, employs the steps of forming a prediction; subtracting the prediction to form a difference; and quantising the difference in a transform domain, where the prediction is formed in the transform domain and the transform domain prediction is weighted. 1. A method of encoding an image in an image encoder utilising a transformation operating between a spatial domain and a transform domain , comprising:forming a prediction;subtracting the prediction to form a difference; andquantising the difference in a transform domain,wherein the prediction is formed in the transform domain and in that the transform domain prediction is weighted.2. A method according to wherein a weighting matrix is defined and a different weight may be applied to each transform domain prediction coefficient.3. A method according to claim 1 , wherein the transformation is applied to image blocks and wherein the weighting varies between image blocks.4. A method of encoding a succession of images according to claim 1 , wherein the weighting varies at least from one image to another.5. A method according to claim 1 , wherein the weighting of the transform domain prediction serves to reduce the relative contribution to the prediction of those transform coefficients having lower accuracy of prediction.6. A method according to claim 1 , wherein the weighting of the transform domain prediction serves to minimise the mean-square error produced by the weighted prediction.7. A method according to claim 1 , wherein the weighting of the transform domain prediction serves to minimise a rate-distortion measure claim 1 , taking into account the prediction error claim 1 , the coefficient bit rate and the bit rate required for the weights.8. A method according to claim 1 , wherein the transformation is a linear transformation or an approximation to a linear transformation.9. A method according to claim 1 ...

GEOLOGICAL MEDIUM EXPLORATION

Systems and methods for geological medium exploration are provided herein. A method of geological medium exploration may include generating vibrations in a geological medium and recording wave-fields at a surface and in a borehole. Additionally, the method may include obtaining a wave field modification operator and applying the wave-field operator to a full range of seismic data to achieve a spectrally-modified wave field. 1. A method of geological medium exploration comprising:generating vibrations in a geological medium;recording wave-fields at a surface and in a borehole;obtaining a wave field modification operator; andapplying the wave-field operator to a full range of seismic data to achieve a spectrally-modified wave field.2. The method of claim 1 , wherein obtaining the wave-field modification operator comprises:calculating a Fourier transformation of a route seismic route x(t);{'sub': 'c', 'calculating a Fourier transformation of a route of reflection coefficients r(t);'}creating an amplitude spectrum product;creating a sum of phase spectra;receiving a complex amplitude and phase spectrum; andperforming a reverse Fourier transformation on the complex spectrum to create a time function X(t).3. The method of claim 2 , wherein the time function X(t) defines the spectral characteristics of the wave field modification operator in the form of{'br': None, 'i': X', 'x', 't', 'e', 'dt=A', 'j, 'o': [{'@ostyle': 'single', 'ω'}, {'@ostyle': 'single', 'ω'}, {'@ostyle': 'single', 'ω'}, {'@ostyle': 'single', 'ω'}], 'sub': '−∞', 'sup': ∞', {'o': {'@ostyle': 'single', 'ω'}, '−j t'}], '( )∫()( )[cos(Φ( ))−sin(Φ)( ))]'}where: A (ω)—amplitude spectrum of the route x(t)Φ (ω)—phase spectrum of the route elastic wave (xt).4. A system for geological medium exploration comprising: at least one surface vibration sensor;', 'at least one borehole sensor; and', obtain a wave field modification operator; and', 'apply the wave-field operator to a full range of seismic data to achieve a ...

DRUMSTICK MOUNTED MUTABLE TAMBOURINE

A drumstick mountable mutable tambourine comprises a body mountable to the drumstick. A block may be attached to the body on which one or more mutable sound making devices are mountable. A muting device may be capable of actuation for muting the mutable sound making devices. 1. A drumstick mountable mutable tambourine , comprising:a body mountable to the drumstick;a block attached to the body on which one or more mutable sound making devices are mountable; anda muting device capable of actuation for muting the mutable sound making devices.2. The drumstick mountable mutable tambourine of claim 1 , wherein the sound making devices comprise one or more cymbals.3. The drumstick mountable mutable tambourine of claim 2 , wherein actuation device comprises a lever.4. The drumstick mountable mutable tambourine of claim 3 , wherein actuation device further comprises a block that is movable by the lever to mute the cymbals.5. A drumstick mountable mutable tambourine claim 3 , comprising:a tubular body mountable to the round drumstick;a block attached radially to the body on which one or more mutable sound making devices are mountable; anda muting device capable of actuation for muting the mutable sound making devices.6. The drumstick mountable mutable tambourine of claim 5 , wherein the sound making devices comprise one or more cymbals.7. The drumstick mountable mutable tambourine of claim 6 , wherein actuation device comprises a lever.8. The drumstick mountable mutable tambourine of claim 7 , wherein actuation device further comprises a block that is movable by the lever to mute the cymbals. The present invention generally relates to a drumstick mounted mutable tambourine. More specifically, the invention relates to the present invention relates to a device that mutes and un-mutes a drumstick tambourine.Attempts have been made to combine percussive instruments to extend the range of effects that a single percussionist can achieve, including providing a combination tambourine ...

SMALL MOLECULE APOPTOSIS PROMOTERS

The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders. 135-. (canceled)38. The compound of claim 36 , wherein each J and J′ is H claim 36 , and each Rand R is H.39. The compound of claim 36 , wherein each Z and Z′ is a 1-aminoalkyl group represented by the formula —CH(R)NR claim 36 , where each R is independently H or C1-C4 alkyl.40. The compound of claim 37 , wherein each J and J′ is H claim 37 , and each Rand R is H claim 37 , and wherein each Z and Z′ is a 1-aminoalkyl group represented by the formula —CH(R)NR claim 37 , where each R is independently H or C1-C4 alkyl.41. The compound of claim 36 , wherein each X and X′ independently comprises a phenyl claim 36 , pyridyl claim 36 , pyrimidyl claim 36 , pyrazinyl claim 36 , pyridazinyl claim 36 , or triazinyl ring claim 36 , each of which may be optionally substituted claim 36 , or a thienyl claim 36 , furanyl claim 36 , pyrrolyl claim 36 , pyrazolyl claim 36 , thiazolyl claim 36 , isothiazolyl claim 36 , oxazolyl claim 36 , isoxazolyl claim 36 , imidazolyl claim 36 , triazolyl claim 36 , thiadiazolyl claim 36 , oxadiazolyl claim 36 , or tetrazolyl ring claim 36 , each of which may be optionally substituted.42. The compound of claim 40 , wherein each X and X′ independently comprises a phenyl claim 40 , pyridyl claim 40 , pyrimidyl claim 40 , pyrazinyl claim 40 , pyridazinyl claim 40 , or triazinyl ring claim 40 , each of which may be optionally substituted claim 40 , or a thienyl claim 40 , furanyl claim 40 , pyrrolyl claim 40 , pyrazolyl claim 40 , thiazolyl claim 40 , isothiazolyl claim 40 , oxazolyl claim 40 , isoxazolyl claim 40 , imidazolyl claim 40 , triazolyl claim 40 , thiadiazolyl claim 40 ...

COMPRESSION OF PICTURES

In video coding, where differences between input picture values and picture prediction values are transformed in a block based transform, the differences are formed in a series of parallel steps. A first step conducted in parallel upon a first subset of pixels uses prediction values based wholly on previously processed blocks. This first subset can include anchor pixels which are not contiguous with any previously processed block. A second step conducted in parallel upon a second subset includes pixels which are predicted from pixels of the first subset. 1. A video compression encoder comprising:a block splitter for receiving picture information and splitting the picture information into spatial blocks of picture elements;a predictor for providing prediction values for the block;a subtractor for receiving picture information and prediction values and forming difference values;a block transform for conducting a transform on the block difference values to provide transform coefficients;wherein the predictor operates in parallel upon the picture elements of a subset of picture elements in the block, there being at least two subsets of picture elements in the block.2. An encoder according to claim 1 , wherein a first subset of picture elements comprises those picture elements which are predicted wholly from previously coded and reconstructed blocks.3. An encoder according to claim 2 , wherein the first subset of picture elements comprises at least one picture element which is not contiguous with any previously processed block.4. An encoder according to claim 3 , wherein the location or value of such a picture element which is not contiguous with any previously processed block is signalled to a decoder.5. An encoder according to claim 1 , wherein a second subset of picture elements comprises picture elements which are predicted at least in part from picture elements of the first subset.6. An encoder according to claim 1 , wherein the prediction of a subset from previous ...

Visual Verification Pharmacy Tray

The present invention provides a pill tray that allows a user to efficiently and reliably verify the contents of an automatically filled prescription. Design features that avoid the presence of sharp edges and allow visualization of the entire surface of the pill tray help reduce and/or eliminate the risk of commingling of pills between separate prescriptions. 1. A pill counting apparatus comprising:a first trapezoidal portion comprising a substantially planar first floor surface comprising first, second, third and fourth sides, the first and third sides of the first trapezoidal portion being substantially parallel to each other, the first side of the first trapezoidal portion characterized by a length that is shorter than the third side of the first trapezoidal portion;a second trapezoidal portion comprising a substantially planar second floor surface comprising first, second, third and fourth sides, the first and third sides of the second trapezoidal portion being substantially parallel to each other, the first side of the second trapezoidal portion characterized by a length that is shorter than the third side of the second trapezoidal portion, the third side of the second trapezoidal portion adjoining the first side of the first trapezoidal portion, the substantially planar second floor surface forming an obtuse angle with respect to the substantially planar first floor surface;an open-ended spout extending from the second trapezoidal portion, the spout comprising a third floor surface adjoining the first side of the second trapezoidal portion;a common sidewall extending upwards from the first floor surface, the second floor surface and the third floor surface;wherein the first trapezoidal portion, the second trapezoidal portion, the spout and the sidewall together define a base portion; anda substantially transparent surface covering the second floor surface, the substantially transparent surface being immoveable with respect to the base portion.2. The apparatus ...

Controlled intermittent fragrance delivery devices and cartomizer cartridge for use therein

Fragrance delivery devices, consistent with embodiments of the present disclosure, may be controlled to deliver a fragrance intermittently and/or selectively. A fragrance delivery device generally includes a housing containing a cartomizer for producing a fragrance vapor from a fragrance liquid, and control circuitry for controlling the production of the fragrance vapor in response to a user input. The fragrance delivery device may include a user interface and/or a wireless interface for connecting to a remote control device, such as a smart phone, tablet, or other computing device, to provide the user input. The fragrance delivery device may deliver the fragrance vapor using natural convection and/or by moving air through the device, for example, with a fan. The fragrance delivery device may also include a power source, such as a battery, and/or may include a connection to an external power source.

LACROSSE STICK HEAD FASTENING SYSTEM AND METHOD FOR FITTING LACROSSE STICK WITH SAME

A lacrosse stick head fastening system is disclosed that prevents loosening of a lacrosse stick head from a lacrosse stick shaft. The lacrosse stick head fastening system generally includes a fastener body that is located in a head fastening end of a lacrosse stick shaft. A transverse fastener extends transversely through a shaft fastening end of the lacrosse stick head, through the head fastening end of the shaft, and through the fastener body. A longitudinal fastener extends longitudinally through the head and into the fastener body. The transverse fastening device secures the shaft fastening end of the head at both sides, and the longitudinal fastening device applies a force longitudinally to maintain the transverse fastening device in side shear stress, thereby preventing both fastening devices from becoming loose during play. Thus, the lacrosse stick head is held onto the shaft with at least three points of contact as opposed to one. 1. A lacrosse stick comprising:a shaft having a head fastening end, the shaft being hollow at least at the head fastening end;a head having a shaft fastening end, wherein the shaft fastening end of the head receives the head fastening end of the shaft; and a fastener body located in the head fastening end of the shaft;', 'a transverse fastening device extending transversely through the shaft fastening end of the head, the head fastening end of the shaft, and the fastener body; and', 'a longitudinal fastening device extending longitudinally through the head and into the fastener body., 'a fastening system fastening the head fastening end of the shaft to the shaft fastening end of the head, the fastening system comprising2. The lacrosse stick of claim 1 , wherein the transverse fastening device includes a two-part cross bolt.3. The lacrosse stick of claim 1 , wherein the longitudinal fastening device includes a self-tapping screw.4. The lacrosse stick of claim 1 , wherein the fastener body is made of a solid piece of material.5. The ...

NRF2 Regulators

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators. 2. The compound or pharmaceutically acceptable salt according to wherein A is —C(O)ORand Ris hydrogen claim 1 , —Calkyl-N(R) claim 1 , —(CH)-morpholinyl claim 1 , —(CH)-imidazoyl claim 1 , —(CH)-pyrrolidinyl claim 1 , or —(CH)-piperidyl.3. The compound or pharmaceutically acceptable salt according to wherein A is —C(O)OH.4. The compound or pharmaceutically acceptable salt according to wherein Ris:{'sub': 1-3', '1-3, 'phenyl substituted by one, two, or three groups independently selected from —CN, —F, —Cl, Calkyl, and —O—Calkyl;'}{'sub': 1-3', '1-3, 'benzotriazolyl substituted by one, two, or three groups independently selected from —O—Calkyl and Calkyl; or'}{'sub': 2', '2', '1-3', '2, '—(CH)-triazolyl substituted by one or two groups independently selected from Calkyl or —CH-phenyl.'}5. The compound or pharmaceutically acceptable salt according to wherein Ris benzotriazolyl substituted by one or two groups independently selected from —O—Calkyl and Calkyl.7. The compound or pharmaceutically acceptable salt according to wherein Ris hydrogen claim 1 , —Cl claim 1 , Calkyl claim 1 , or —CF.8. The compound or pharmaceutically acceptable salt according to wherein each Ris hydrogen.10. The compound according to selected from the group consisting of:3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((5-methyl-1,1-dioxido-4,5-dihydrobenzo[f][1,2,5]thiadiazepin-2(3H)-yl)methyl)phenyl)propanoic acid;3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((5-methyl-1,1-dioxido-4,5-dihydrobenzo[f][1,2,5]thiadiazepin-2(3H)-yl)methyl)phenyl)propanoic acid;3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)propanoic acid;3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((3-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5] ...

SYSTEM AND METHOD FOR IMPROVING RESILIENCE IN TRANSMISSION OF DATA FRAGMENTS

A system and method packetizes data by fragmenting, with processing circuitry, a data structure into a plurality of data fragments, each data fragment being included in a separate packet, and inserting, with processing circuitry, an offset indicator within each of the packets, each offset indicator indicating an amount of fragment data encapsulated within preceding packets. A system and method decodes packetized data that includes the offset indicator. 1. A method of packetizing data , the method comprising:fragmenting, with processing circuitry, a data structure into a plurality of data fragments, each data fragment being included in a separate packet; andinserting, with processing circuitry, an offset indicator within each of the packets, each offset indicator indicating an amount of fragment data encapsulated within preceding packets.2. The method according to claim 1 , whereineach packet includes a header, andthe offset indicator of each packet is located within the header.3. The method according to claim 1 , whereinin the fragmenting, each data fragment is included in the separate transmission packet in a packet order, andin the inserting, each offset indicator indicates the amount of fragment data of the same data structure encapsulated within preceding packets in the packet order.4. The method according to claim 2 , further comprising:partitioning, with processing circuitry, the data structure into a plurality of tiles in a tile order, whereinthe data structure includes a structure header that includes the tile order and tile offset entry points within the data structure.5. The method according to claim 4 , whereina tile of the plurality of tiles includes a first part and a second part, andthe tile is fragmented between more than one packet so that the first part of the tile is included in a first part and the second part of the tile is included in a second packet in the packet order.6. The method according to claim 4 , wherein the header of a first packet in ...

FINE-GRAINED ENCRYPTED ACCESS TO ENCRYPTED INFORMATION

The present disclosure provides systems, methods, and computer-readable media for performing a fine-grained encrypted search of data stored in encrypted form. In one aspect, a system includes at least one processor and at least one memory having computer-readable instructions, which when executed by the at least one processor, configure the at least one processor to create an encrypted search database, perform an encrypted search of the encrypted search database based on one or more search terms, present a result of the encrypted search on an interface, and perform a further search of an encrypted data storage based on a response to the result. 1. A system comprising:at least one processor; and create an encrypted search database,', 'perform an encrypted search of the encrypted search database based on one or more search terms,', 'present a result of the encrypted search on an interface, and', 'perform a further search of an encrypted data storage based on a response to the result., 'at least one memory having computer-readable instructions, which when executed by the at least one processor, configure the at least one processor to2. The system of claim 1 , wherein the execution of the computer-readable instructions further configures the at least one processor to generate the encrypted search database by:converting incoming information to text;splitting the text into a plurality of chunks of text;encrypting the plurality of chunks of text; andstoring the plurality of chunks of text in a database to create the encrypted search database.3. The system of claim 2 , wherein the execution of the computer-readable instructions configures the at least one processor to claim 2 ,split the incoming information into a plurality of chunks of data;encrypt the plurality of chunks of data; andstore the plurality of chunks of data in the encrypted data storage.4. The system of claim 3 , wherein the execution of the computer-readable instructions configures the at least one processor ...

NANOPARTICLE ENCAPSULATION TO TARGET G PROTEIN-COUPLED RECEPTORS IN ENDOSOMES

The present invention relates to methods for modulating endosomal GPCR signaling. In particular, the present invention relates to use of polymeric nanoparticles for the targeted delivery of hydrophobic modulators of endosomal GPCRs and their use in the treatment of associated diseases and disorder. 1. An aqueous liquid comprising polymeric nanoparticles of copolymer chains assembled to form a core/shell structure , the copolymer chains having:(i) an acid-responsive hydrophobic polymer block that forms the core of the nanoparticles; and(ii) a hydrophilic polymer block that forms the shell of the nanoparticles and is solvated by the aqueous liquid,wherein the nanoparticles contain within their core a hydrophobic modulator of endosomal GPCR signaling, or a pharmaceutically acceptable salt thereof.2. The aqueous liquid according to claim 1 , wherein the acid-responsive hydrophobic polymer block comprises tertiary amine functional groups that are protonated in an acidic environment claim 1 , optionally wherein the tertiary amine functional groups are protonated at about pH=6.1.3. The aqueous liquid according to claim 1 , wherein the acid-responsive hydrophobic polymer block comprises a homopolymer or copolymer of 2-(diisopropylamino)ethyl methacrylate (DiPAEMA).4. The aqueous liquid according to claim 1 , wherein the acid-responsive hydrophobic polymer block comprises a copolymer of 2-(diisopropylamino)ethyl methacrylate (DiPAEMA) and a polyalkyleneoxide methacrylate.5. (canceled)6. The aqueous liquid according to claim 1 , wherein the hydrophilic polymer block comprises a copolymer of poly(ethylene glycol)methacrylate (PEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA).7. (canceled)8. The aqueous liquid according to claim 1 , wherein the hydrophobic modulator of endosomal GPCR signaling or pharmaceutically acceptable salt thereof is an inhibitor of an endosomal GPCR.9. The aqueous liquid according to claim 1 , wherein the hydrophobic modulator of endosomal GPCR ...

Beverage Container

The present disclosure relates to beverage container () that includes a lower vessel () having a lower vessel neck (), an upper vessel () that is attached to the lower vessel neck () and is sized and shaped to hold a liquid therein, a removable cap () that is attached to the upper vessel (), a vessel seal () that serves as a liquid- tight barrier between the interior of the upper vessel () and the interior of the lower vessel (), and a tether () attached to the vessel seal () at one end and the removable cap () at the other end. When the removable cap () is twisted or removed, it pulls on the tether (), which pulls and releases the vessel seal (), thereby allowing liquid from inside the upper vessel () to enter the interior of the lower vessel (). 1. A container comprising:a vessel including a first end, a second end distal to the first end, and a vessel wall extending from the first end to the second end, the first end, second end, and vessel wall defining an internal volume of the vessel;a cap secured to the first end of the vessel; anda seal removably-secured to the vessel wall, the seal being sized and positioned to span the internal volume when secured to the vessel wall and to separate the internal volume into a first portion and a second portion, the seal including a tether having a first end and a second end distal from the first end, the first end of the tether being attached to the seal and the second end of the tether being attached to the cap,wherein the cap, the seal, and the tether are adapted to (a) allow the seal to remain secured to the vessel wall when the cap is in a first position at the first end of the vessel, (b) to cause the seal to at least partially separate from the vessel wall when the cap is moved to a second position, and (c) to allow the tether to remain attached to the seal and the cap when the cap is moved to the second position.2. The container of claim 1 , wherein the vessel comprises an upper vessel located proximate to the first ...

SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS

Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. 1. (canceled)2. The method of claim 5 , wherein Ris substituted bicyclic heteroaryl or bicyclic heterocyclyl selected from the group consisting of 1H-indolyl claim 5 , 2H-indazolyl claim 5 , 4 claim 5 ,5 claim 5 ,6 claim 5 ,7-tetrahydro-2H-indazolyl claim 5 , 1H-benzimidazolyl claim 5 , imidazo[2 claim 5 ,1-b][1 claim 5 ,3]thiazolyl claim 5 , pyrazolo[1 claim 5 ,5-a]pyridinyl claim 5 , pyrazolo[1 claim 5 ,5-c]pyrimidinyl claim 5 , imidazo[1 claim 5 ,2-a]pyridinyl claim 5 , 5 claim 5 ,6 claim 5 ,7 claim 5 ,8-tetrahydroimidazo[1 claim 5 ,2-a]pyridinyl claim 5 , 1H-imidazo[4 claim 5 ,5-b]pyridinyl claim 5 , 1H-imidazo[4 claim 5 ,5-c]pyridinyl claim 5 , 4 claim 5 ,5 claim 5 ,6 claim 5 ,7-tetrahydro-3H-imidazo[4 claim 5 ,5-c]pyridinyl claim 5 , imidazo[1 claim 5 ,2-a]pyrazinyl claim 5 , imidazo[1 claim 5 ,2-a]pyrimidinyl claim 5 , 7H-purinyl and quinolinyl.3. The method of claim 2 , wherein Ris substituted bicyclic heteroaryl selected from the group consisting of 1H-indolyl claim 2 , 1H-benzimidazolyl claim 2 , pyrazolo[1 claim 2 ,5-a]pyridinyl claim 2 , imidazo[1 claim 2 ,2a]pyridinyl claim 2 , 1H-imidazo[4 claim 2 ,5-b]pyridinyl claim 2 , imidazo[1 claim 2 ,2a]pyrazinyl and imidazo[1 claim 2 ,2-a]pyrimidinyl.4. (canceled)6. The method of claim 5 , further comprising contacting a cell having elevated Bmi-1 levels from the subject with an amount of the compound claim 5 , or form thereof claim 5 , wherein the cell is selected from the group consisting of a cancer cell claim 5 , tumor cell claim 5 , cancer stem cell and tumor stem cell claim 5 , determining an effective amount of the compound claim 5 , or form thereof claim 5 , that inhibits ...

USE OF ANTI-PD-1 ANTIBODY IN COMBINATION WITH ANTI-CD27 ANTIBODY IN CANCER TREATMENT

This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof. 1. A method for treating a subject afflicted with a tumor comprising administering the subject in need thereofan antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“anti-PD-1 antibody or antigen-binding portion thereof”) in combination withan antibody or an antigen-binding portion thereof that specifically binds to CD27 (“anti-CD27 antibody or antigen-binding portion thereof”).2. The method of claim 1 , wherein the tumor is colorectal cancer claim 1 , rectal cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , melanoma claim 1 , ovarian cancer claim 1 , head and neck cancer claim 1 , or any combination thereof.3. The method of claim 2 , wherein the lung cancer is non-small cell lung cancer (NSCLC).4. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof cross-competes with nivolumab for binding to human PD-1.5. The method of claim 1 , wherein the anti-CD27 antibody or antigen-binding portion thereof cross-competes with varlilumab for binding to human CD27.6. The method of claim 1 , wherein:(i) the anti-PD-1 antibody is nivolumab;(ii) the anti-CD27 antibody is varlilumab; or(iii) the anti-PD-1 antibody is nivolumab and the anti-CD27 antibody is varlilumab.7. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose ranging from at least about 0.1 mg/kg to at least about 10.0 mg/kg body weight once about every 1 claim 1 , 2 or 3 weeks.8. The method of claim 7 , wherein the anti-PD-1 antibody or antigen-binding portion thereof is administered at a dose of at ...

SAFETY SYSTEM FOR HIGH VOLTAGE NETWORK GROUNDING SWITCH

The present invention is directed to a safety system integrated into a liquid-insulated high voltage network grounding switch, including modifications to the switch structure to provide an arrangement that is more efficiently installed with greater precision than found in conventional arrangements. The result is a switch assembly that adheres to updated IEEE/ANSI Standards, while still fitting into existing vault space meant to accommodate earlier switch gear. 1. A high voltage network grounding switch safety system operationally mounted to a liquid-tight tank , wherein said network grounding switch includes a rotary multi-position , 3-phase arrangement comprising at least three switch input connecting points , at least three rotating paired blades affixed to a shaft , each paired blade interfacing with at least one switch output connection , the grounding switch safety system further including a ground bus , an exterior ground connector , at least three secondary switch blades , and incoming bushings with each bushing having internal and external electrical connection points , and further wherein said tank is configured with a mounting structure for securing at least a portion of said network grounding switch within said liquid containment tank , and wherein said switch safety system further comprises:a) a liquid-tight gland for passage of the shaft to an external handle to control rotation of said shaft from outside said tank;b) an offset interface between said external handle and said drive shaft of said network grounding switch for extension through said gland;c) an exterior safety shear pin secured to said external handle and said shaft;d) a ground path connecting a tank interior and said switch through an internal plate fixed in proximity to said liquid-tight gland; ande) a flexible connection between at least one of said switch input connecting points and at least one of said internal electrical connection points of said incoming bushings; and,f) wherein each ...

DISTRIBUTED LEARNING VIDEO ENCODER/DECODER

In one embodiment, one or more portions of video content that were encoded by a video encoder are identified. The one or more portions of video content are to be analyzed for improving encoding performance of the video encoder. The one or more portions of the video content are stored. During an idle time period of the video encoder, the one or more portions of video content are analyzed in combination with a test set stored by the video encoder in order to modify one or more functions of an encoding process used by the video encoder. Based on the analysis, one or more modifications to the encoding process are determined that result in improved performance of the video encoder. 1. A method comprising:at a video encoder, identifying one or more portions of video content that was encoded by the video encoder, the one or more portions of video content to be analyzed for improving encoding performance of the video encoder;storing the one or more portions of the video content;during an idle time period of the video encoder, analyzing the one or more portions of video content in combination with a test set stored by the video encoder in order to modify one or more functions of an encoding process used by the video encoder; andbased on the analyzing, determining one or more modifications to the encoding process that results in improved performance of the video encoder.2. The method of claim 1 , further comprising:storing state of the video encoder while the video encoder encoded the one or more portions of video content, the state including content of internal buffers and data of state variables of the encoding process.3. The method of claim 2 , wherein further comprising:capturing and storing new video content obtained by the video encoder; andduring an idle time period of the video encoder, applying the encoding process using the state of the video encoder with the one or more modifications to the new video content.4. The method of claim 3 , further comprising:determining ...

SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS

Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. 120-. (canceled)21. A compound , wherein the compound is 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4 ,6-diamine , or a pharmaceutically acceptable salt thereof.22. A pharmaceutical composition comprising the compound claim 21 , or pharmaceutically acceptable salt thereof claim 21 , of and at least one pharmaceutically acceptable excipient.23. The pharmaceutical composition of claim 22 , wherein the pharmaceutical composition comprises about 0.1 ng to about 3500 mg of the compound or pharmaceutically acceptable salt thereof.24. The pharmaceutical composition of claim 23 , wherein the pharmaceutical composition comprises about 5.0 mg to about 1500 mg of the compound or pharmaceutically acceptable salt thereof.25. The pharmaceutical composition of claim 22 , wherein the pharmaceutical composition further comprises one or more additional agents selected from the group consisting of anti-cancer agents claim 22 , anti-proliferative agents claim 22 , chemotherapeutic agents claim 22 , immunomodulatory agents claim 22 , anti-angiogenic agents claim 22 , anti-inflammatory agents claim 22 , alkylating agents claim 22 , steroidal and non-steroidal anti-inflammatory agents claim 22 , pain relievers claim 22 , leukotriene antagonists claim 22 , β2-agonists claim 22 , anticholinergic agents claim 22 , hormonal agents claim 22 , biological agents claim 22 , tubulin binding agents claim 22 , glucocorticoids claim 22 , corticosteroid agents claim 22 , antibacterial agents claim 22 , antihistamines claim 22 , anti-malarial agents claim 22 , anti-viral agents claim 22 , and antibiotics.26. The ...

ORCHESTRATION MANAGEMENT OF INFORMATION TECHNOLOGY

Embodiments of the invention are directed to a system, method, or computer program product for an orchestration management database (OMDB). The OMDB provides for aggregation of vendor and bank data necessary for information technology infrastructure deployment, management, and federation. Utilizing cloud computing technology the OMDB provides an aggregation of all data necessary for information technology infrastructures within an entity into one useable database that dramatically simplifies the ability to do core functions and integrate external vendors and components with the entity's information technology infrastructure. In this way, the present invention modularly stores data required for an entity's information technology infrastructure and allows for easy deployment, intelligent monitoring, federation of data, and feedback associated with all aspects of the entity's information technology infrastructure. 1. A system for providing aggregation of vendor and entity data for an information technology infrastructure , the system comprising:a memory device with computer-readable program code stored thereon;a communication device; receive information technology resources at a platform, wherein the information technology resources comprises data that an entity requests for use within the information technology infrastructure;', 'determine the information technology resources on the platform necessary for deploying and building components within the information technology infrastructure, such that the information technology resources are deployable in a step-by-step sequence for building the components within the information technology infrastructure;', 'create a dynamic list of the information technology resources and step-by-step sequence for building the components, wherein the dynamic list is stored in real-time;', 'deploy the information technology resources in the step-by-step sequence for building of a user system within the information technology ...

END TO END MODULAR INFORMATION TECHNOLOGY SYSTEM

Embodiments of the invention are directed to a system, method, or computer program product for providing an information technology build service for building a platform in response to a service request. The invention receives a service request for the platform build from a requester, receives a plurality of platform parameters from the requester, determines whether the service request requires one or more physical machines or one or more virtual machines, and if the service request requires one or more virtual machines, initiates build of the one or more virtual machines. The invention also provisions physical and virtual storage based on received parameters, provisions physical and virtual processing power based on received parameters, and manages power of resources during the build, the managing comprising managing power ups, power downs, standbys, idles and reboots of one or more physical components being used for the build. 1. A system for providing an information technology build service for building a platform in response to a service request , the system comprising:a memory device with computer-readable program code stored thereon;a communication device; receive a service request for the platform build from a requester;', 'receive a plurality of platform parameters from the requester;', 'determine whether the service request requires one or more physical machines or one or more virtual machines;', 'if the service request requires one or more virtual machines, initiate build of the one or more virtual machines;', 'provision physical and virtual storage based on received parameters;', 'provision physical and virtual processing power based on received parameters; and', 'manage power of resources during the build, the managing comprising managing power ups, power downs, standbys, idles and reboots of one or more physical components being used for the build., 'a processing device operatively coupled to the memory device and the communication device, wherein the ...

HOST NAMING APPLICATION PROGRAMMING INTERFACE

Embodiments of the invention are directed to a system, method, or computer program product for providing a unique naming framework for a plurality of virtual machines attached to a network. The invention may include receiving a service request for a platform build from a requester and receiving a plurality of build parameters associated with the platform build from the requester. Then, the invention may apply a set of naming rules to one or more attributes (that may be based on the received build parameters) associated with one or more virtual machines, assign a unique name to each individual virtual machine based on the set of naming rules and publish at least one of the assigned unique names over the network, thereby providing access to the virtual machine associated with the unique assigned name in response to an internet protocol network request or request to resolve a host name. 1. A system for providing a unique naming framework for a plurality of virtual machines attached to a network , the system comprising:a memory device with computer-readable program code stored thereon;a communication device; apply a set of naming rules to one or more attributes associated with one or more virtual machines;', 'assign a unique name to each individual virtual machine based on the set of naming rules; and', 'publish at least one of the assigned unique names over the network., 'a processing device operatively coupled to the memory device and the communication device, wherein the processing device is configured to execute the computer-readable program code to2. The system of claim 1 , wherein the processing device is further configured to execute the computer-readable program code to:receive a service request for a platform build from a requester;receive a plurality of build parameters associated with the platform build from the requester; and wherein:the one or more attributes associated with the one or more virtual machines are based at least in part on some or all the ...

DEVICES AND METHODS FOR REMOVAL OF MATERIAL IN A VASCULATURE

Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material. 134.-. (canceled)36. The handheld device of claim 35 , wherein the proximal rotating element comprises:a trigger configured to generate a linear motion; andan actuation system configured to translate the linear motion into a rotational motion, the rotational motion configured to rotate the catheter.37. The handheld device of claim 36 , wherein the trigger comprises a lever claim 36 , a high pivot point trigger claim 36 , or a low pivot point trigger.38. The handheld device of claim 36 , wherein the actuation system further comprises a gear set claim 36 , a helix claim 36 , and a pair of shuttles.39. The handheld device of claim 38 , wherein the actuation system is separated from a flow path of the lumen configured to contain the material being removed from the vasculature.40. The handheld device of claim 36 , wherein the actuation system further comprises a gear set claim 36 , a constant force spring claim 36 , and a one-way locking bearing.41. The handheld device of claim 40 , wherein the actuation system is separated from a flow path of the lumen configured to contain the material being removed from the vasculature.42. The handheld device of claim 35 , further comprising a rotational seal claim 35 , the rotational seal configured to allow the negative pressure element to remain stationary during rotation of the proximal rotating element and the catheter.43. The handheld device of claim 35 , wherein the proximal rotating element is configured ...

Visual Verification Pharmacy Tray

The present invention provides a pill tray that allows a user to efficiently and reliably verify the contents of a filled prescription. Design features that avoid the presence of sharp edges and allow visualization of the entire surface of the pill tray help reduce and/or eliminate the risk of commingling of pills between separate prescriptions. 1. An apparatus comprising:a first trapezoidal portion comprising a substantially planar first floor surface comprising first, second, third and fourth sides, the first and third sides of the first trapezoidal portion being substantially parallel to each other, the first side of the first trapezoidal portion characterized by a length that is shorter than the third side of the first trapezoidal portion;a second trapezoidal portion comprising a substantially planar second floor surface comprising first, second, third and fourth sides, the first and third sides of the second trapezoidal portion being substantially parallel to each other, the first side of the second trapezoidal portion characterized by a length that is shorter than the third side of the second trapezoidal portion, the third side of the second trapezoidal portion adjoining the first side of the first trapezoidal portion, an entirety of the substantially planar second floor surface forming an obtuse angle with respect to an entirety of the substantially planar first floor surface;an open-ended spout extending from the second trapezoidal portion, the spout comprising a third floor surface adjoining the first side of the second trapezoidal portion;a common sidewall extending upwards from the first floor surface, the second floor surface and the third floor surface;wherein the first trapezoidal portion, the second trapezoidal portion, the spout and the sidewall together define a base portion; anda substantially transparent surface covering the second floor surface, the substantially transparent surface being immoveable with respect to the base portion and including ...

BEVERAGE CONTAINER

The present dosure relates to beverage container () that includes a lower vessel () having a lower vessel neck (), an upper vessel () that is attached to the lower vessel neck () and is sized and shaped to hold a liquid therein, a removable cap () that is attached to the upper vessel (), a vessel seal () that serves as a liquid- tight barrier between the interior of the upper vessel () and the interior of the lower vessel (), and a tether () attached to the vessel seal () at one end and the removable cap () at the other end. When the removable cap () is twisted or removed, it pulls on the tether (), which pulls and releases the vessel seal (), thereby allowing liquid from inside the upper vessel () to enter the interior of the lower vessel (). 1. A container comprising:a vessel including a lower end, an upper end distal to the lower end, and a vessel wall extending from the upper end to the lower end, the upper end, lower end, and vessel wall defining an internal volume of the vessel;a cap secured to the upper end of the vessel;a seal removably-secured to the vessel wall, the seal being sized and positioned to span the internal volume when secured to the vessel wall and to separate the internal volume into an upper portion and a lower portion, the seal including a tether that is secured to the cap;wherein the cap, the seal, and the tether are adapted to allow the seal to remain secured to the vessel wall when the cap is in a closed position at the upper end of the vessel and to cause the seal to at least partially separate from the vessel wall when the cap is moved to an active position.2. The container of claim 1 , further comprising:a first ingredient located in the upper portion of the internal volume; anda second ingredient located in the lower portion of the internal volume, the second ingredient being of a different composition than that of the first ingredient.3. The container of claim 1 , wherein the cap is in a different rotational position relative to the ...

EMBEDDABLE MODULE FOR HIGH OUTPUT LED

In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. 144.-. (canceled)45. An adapter configured for removable and replaceable coupling to a light module , comprising:a housing having a plurality of external threads for engaging with a plurality of internal threads disposed at an end of the light module for coupling the adapter to the light module,said housing of the adapter having a central hollow channel for receiving at least a portion of a light guide.46. The adapter of claim 45 , wherein said housing further comprises an opening on a lateral surface thereof.47. The adapter of claim 46 , further comprising a retaining pin configured for being received in said opening for securing the light guide within the adapter.48. The adapter of claim 45 , wherein said hollow channel is substantially cylindrical.49. The adapter of claim 45 , wherein said light guide comprises an optical fiber.50. The adapter of claim 45 , wherein said light guide comprises a bundle of optical fibers.51. The adapter of claim 45 , wherein said light guide comprises a liquid light guide.52. The adapter of claim 45 , wherein said light module comprises a retaining window.53. The adapter of claim 52 , wherein said retaining window comprises a plurality of internal threads for engaging with said external threads of the housing of the adapter for coupling the adapter ...

ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME

Gelatinous materials combined with the Colloidal Silver additive to formulate an antimicrobial product having cushioning properties. Embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface. 2. The product according to claim 9 , wherein the product is a flat mat.3. The product according to claim 2 , wherein the mat has raised geometric projections on at least one surface of the mat.4. The product according to wherein the mat is an exercise mat.5. The product according to claim 2 , wherein the mat is rolled and joined at opposing ends to form a substantially circular roller.6. The product according to claim 5 , wherein the circular roller has raised geometric projections on the outer surface of the roller.7. The product according to claim 5 , wherein the mat is rolled around an insert.8. The product according to claim 7 , wherein the circular roller has raised geometric projections on the surface of the roller.9. The product according to claim 2 , wherein the mat is a shoe insert. The present invention is a Continuation of U.S. Continuation patent application Ser. No. 14/583,975, filed Dec. 29, 2014, which claims the benefit of U.S. Non-Provisional application Ser. No. 13/151,937, filed Jun. 2, 2011, which claims the benefit of U.S. Provisional Application Ser. No. 61/350,626, filed on Jun. 2, 2010, all are incorporated herein by reference.The present invention is related generally to the field of antimicrobial products, and in particular antimicrobial colloidal silver products.Traditionally, TPE Gels (Thermoplastic Elastomers) are developed by the hydrogenation of tri-block co-polymers of styrene and butadene. The present invention formulation allows for the glass transition of its rubber block below −50° C. thus maintaining its ...

ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME

Gelatinous materials combined with the Colloidal Silver additive to formulate an antimicrobial product having cushioning properties. Embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface. 2. The product according to claim 1 , wherein the mat has raised geometric projections on at least one surface of the mat.3. The product according to claim 2 , wherein the mat is an exercise mat.4. The product according to claim 1 , wherein the mat is rolled and joined at opposing ends to form a substantially circular roller.5. The product according to claim 4 , wherein the circular roller has raised geometric projections on the outer surface of the roller.6. The product according to claim 4 , wherein the mat is rolled around an insert.7. The product according to claim 6 , wherein the circular roller has raised geometric projections on the surface of the roller.8. The product according to claim 1 , wherein the mat is a shoe insert.10. The product according to claim 9 , wherein the cylinder has raised geometric projections on the surface of the cylinder. The present invention is a Continuation Application of U.S. Non-Provisional application Ser. No. 13/151,937, entitled “ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME” filed Jun. 2, 2011, which claims benefit of U.S. Provisional Application Ser. No. 61/350,626, entitled ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME, filed on Jun. 2, 2010, all are incorporated herein by reference.The present invention is related generally to the field of antimicrobial products, and in particular antimicrobial colloidal silver products.Traditionally, TPE Gels (Thermoplastic Elastomers) are developed by the hydrogenation of tri-block co-polymers of styrene and butadene. The ...

SHAPED-BASED TECHNIQUES FOR EXPLORING DESIGN SPACES

In various embodiments, a training application generates a trained encoder that automatically generates shape embeddings having a first size and representing three-dimensional (3D) geometry shapes. First, the training application generates a different view activation for each of multiple views associated with a first 3D geometry based on a first convolutional neural network (CNN) block. The training application then aggregates the view activations to generate a tiled activation. Subsequently, the training application generates a first shape embedding having the first size based on the tiled activation and a second CNN block. The training application then generates multiple re-constructed views based on the first shape embedding. The training application performs training operation(s) on at least one of the first CNN block and the second CNN block based on the views and the re-constructed views to generate the trained encoder. 1. A computer-implemented method for training a neural network to generate representations of three-dimensional (3D) shapes , the method comprising:for each view included in a pluralilty of views associated with a first 3D geometry, performing one or more convolutions to generate a view activation;generating a tiled activation based on the view activations;performing one or more convolutions on the tiled activation to generate a shape embedding;performing one or more transposed convolutions on the shape embedding to generated a decoded tiled activation;splitting the decoded tiled activation into a plurality of decoded view activations; andfor each decoded view activation, performing one or more transposed convolutions to generate at least one reconstructed view associated with the first 3D geometry.2. The computer-implemented method of claim 1 , wherein the shape embedding includes a first vector having a fixed size that is based on the tiled activation.3. The computer-implemented method of claim 2 , wherein the fixed size is selected to ...

ANTIMICROBIAL COLLOIDAL SILVER AND GOLD PRODUCTS AND METHOD OF MAKING SAME

Gelatinous foam, coated paper, fabric, and polymer materials combined with the Colloidal Silver or Gold additive to formulate products with antimicrobial surfaces. Some embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface and in any shape. The various embodiments include coated polymer sheets, polymer trays, bamboo and/or cotton towels and fabric, polymer foam, or polymer mats containing nano-silver or nano-gold in an scheduled and organized manner (with input/requests from the customer) to create permanent or semi-permanent anti-microbial surfaces. 1. An antimicrobial colloidal product comprising a gelatinous material with a colloidal silver or gold additive suspended within the gelatinous material , wherein colloidal additive concentration is about 200 to about 2000 PPM.2. The antimicrobial colloidal product according to claim 1 , wherein the gelatinous material is selected from a group consisting of a thermosetting polymer claim 1 , Styrene-Ethylene-Butadiene-Styrene polymer (SEBS) claim 1 , Thermoplastic Elastomer (TPE) claim 1 , and Polyurethane (PU) gelatin.3. The antimicrobial colloidal product according to claim 1 , wherein the antimicrobial colloidal product has hardness and softness ranging from 0 to 40 on the shore A scale and harder consistencies on the Shore DD Scale from 0 to 80.4. The antimicrobial colloidal product according to claim 3 , wherein the TPE comprises of 0 to 40 on the 00 scale of measurement (Durometer).5. An antimicrobial colloidal product comprising:a polymeric methylene diphenyl di-isocyanate (MDI) 100%;a 265 Molecular weight (Mw) polyether triol 100%;a Ratio of the polymeric methylene diphenyl di-isocyanate to the polyether triol of about 1:1;wherein a Shore D is about 80; andan anti-microbial ...

Handheld Mobile Light Source

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments. 1. A handheld lighting system , comprising:a handheld housing extending from a proximal end to a distal end,a light module disposed removably and replaceably in said housing and having at least a light source for generating light, said light module having an adapter disposed at said distal end of the housing for coupling the light module to a light guide such that the light guide receives the light generated by the light module,a power module disposed within said housing and electrically coupled to said light module for providing electrical power thereto.2. The handheld lighting system of claim 1 , wherein said adapter is removable and replaceable.3. The handheld lighting system of claim 1 , wherein said handheld housing comprises a corrugated external surface for facilitating transfer of heat generated by at least one of the light module and the power module to an external environment.4. The handheld lighting system of claim 1 , wherein said power module allows adjusting an intensity of the light generated by said light module.5. The handheld lighting system of claim 1 , wherein said light guide comprises an optical fiber.6. The handheld lighting system of claim 1 , wherein said light module comprises a pair of electrical ...

ENTROPY CODING STATE SEGMENTATION AND RETENTION

Video coding and decoding techniques are provided in which entropy coding states are stored for regions of video frames of a sequence of video frames, upon completion of coding of those regions. Entropy coding initialization states for regions of a current video frame are derived based on entropy coding states of corresponding regions of a prior video frame in the sequence of video frames. This process may be performed at a video encoder and a video decoder, though some signaling may be sent from the encoder to the decoder to direct the decoder is certain operations. 1. A method comprising:storing entropy coding states for regions of video frames of a sequence of video frames, on completion of coding of those regions; andderiving entropy coding initialization states for regions of a current video frame based on entropy coding states of corresponding regions of a prior video frame in the sequence of video frames.2. The method of claim 1 , further comprising defining individual regions in order to encompass a specific type of picture content so that regions of different types of picture content are treated differently when deriving entropy coding initialization states.3. The method of claim 1 , further comprising updating the stored entropy coding states for regions over time.4. The method of claim 3 , wherein deriving comprises selecting a prior video frame from which to use entropy coding state for deriving the entropy coding state of the current video frame.5. The method of claim 4 , further comprising adjusting the entropy coding state of a selected prior video frame based on a difference in parametrization of the current frame relative to the selected prior frame or based on one or more properties of content of the current frame relative to the selected prior frame.6. The method of claim 4 , wherein when the current video frame has a different segmentation than that of a selected prior video frame claim 4 , deriving comprises combining with weighting of regions ...

Continuous Generation of Non-Displayed Reference Frame in Video Encoding and Decoding

Methods and systems for the transmission of a high quality background reference frame (HQRF). Such a reference frame is sent from a video encoder to a video decoder in a number of portions, or slices. In the context of this description, a slice of a frame is a set of blocks in the frame, where the slice is coded separately from other slices of the frame. The slices are sent at respective intervals, so that the decoder receives the high quality background reference frame over time, in a piecemeal fashion. The slices can be buffered at the decoder, and the buffer may be continuously updated and used for reference at any point. 1. A method of creating a background reference frame at a video decoder comprising:at each of a plurality of time intervals,receiving one or more coded, high fidelity portions of a background reference frame from a video encoder;decoding the one or more portions; andstoring the one or more decoded portions in a buffer such that, after the plurality of time intervals, some or all of a background reference frame is stored in the buffer.2. The method of claim 1 , wherein each portion represents 1 to 2% of the background reference frame and each time interval is 0.5 seconds to 5.0 seconds in length.3. The method of claim 1 , further comprising: receiving subsequent data that is predictively coded by reference to data in the background reference frame.4. The method of claim 3 , further comprising: prediction that is performed on the on the subsequently received data using a partially complete background reference frame.5. The method of claim 4 , wherein the background reference frame comprises incomplete regions that contain default data claim 4 , the default data comprising data from another reference frame or a constant tone color.6. The method of claim 1 , further comprising:receiving an updated portion of the background reference frame;decoding the updated portion to produce a decoded updated portion; andoverwriting a corresponding portion of the ...

ROBOTIC CLIMBING PLATFORM

A robotic climbing platform has a chassis and a carriage adapted to support and move the chassis relative to a climbing surface. An adhesion mechanism provides an adhesion force between the climbing platform and the climbing surface. The adhesion mechanism has one or more suction pads adapted to retain an adhesion force between the climbing platform and the climbing surface during movement of the chassis relative to the climbing surface. 1. A robotic climbing platform comprising:a chassis adapted to support a control system and an adhesion mechanism,the adhesion mechanism comprising at least one actuator and one or more suction pads adapted to form an adhesion force between the climbing platform and a climbing surface,the control system comprising a controller configured to receive a signal from one or more sensors adapted to measure the adhesion force between the suction pad and the climbing surface, the controller further configured to output a signal to cause movement of the actuator, and compare the measured the adhesion force to one or more characteristics.2. A robotic climbing platform as claimed in claim 1 , wherein the actuator has a first end connected to the chassis and another end connected to a suction pad claim 1 , the actuator adapted to cause movement of the suction pad toward to the climbing surface by application of a first force and cause movement of the suction pad toward the chassis by application of a second force such that a seal between the climbing surface the suction pad is achieved.3. A robotic climbing platform as claimed in or claim 1 , wherein one characteristic is a predetermined optimum adhesion force indicated by one or more of:the vacuum between the suction pad and the climbing surface,the distance between the actuator and the climbing surface, orthe location of the seal.4. A robotic climbing platform as claimed in any one of to claim 1 , wherein the controller is further configured to output a signal to vary the second force such ...

SHAPED-BASED TECHNIQUES FOR EXPLORING DESIGN SPACES

In various embodiments, a training application generates a trained encoder that automatically generates shape embeddings having a first size and representing three-dimensional (3D) geometry shapes, First, the training application generates a different view activation for each of multiple views associated with a first 3D geometry based on a first convolutional neural network (CNN) block. The training application then aggregates the view activations to generate a tiled activation. Subsequently, the training application generates a first shape embedding having the first size based on the tiled activation and a second CNN block. The training application then generates multiple re-constructed views based on the first shape embedding. The training application performs training operation(s) on at least one of the first CNN block and the second CNN block based on the views and the re-constructed views to generate the trained encoder. 1. A computer-implemented method for automatically exploring design spaces , the method comprising:displaying one or more designs included in a first plurality of designs via a graphical user interface (GUI), wherein the first plurality of designs defines, at least in part, a design space, and each design included in the first plurality of designs is associated with a different shape embedding that describes the shape of the design;in response to receiving a command via the GUI, determining one or more target designs included in the first plurality of designs based on at least a first shape embedding and first metadata associated with at least a first design included in the first plurality of designs; anddisplaying the one or more target designs via the GUI, wherein the target designs reflect a preference associated with the first command.2. The method of claim 1 , wherein the first metadata comprises at least one of functional data claim 1 , manufacturability data; manufacturing status data claim 1 , a constraint associated with a generative ...

RECOVERY AND PURIFICATION OF MONOVALENT SALT CONTAMINATED WITH DIVALENT SALT

A method and system for improving the quality and quantity of a soluble salt recovered from the supernatant produced when concentrated solutions are mixed to precipitate an insoluble salt are disclosed. Liquid residual, or supernatant, contains salt that is reusable in the regeneration solution of ion removal devices such as ion exchange or electrodialysis metathesis (EDM). The disclosed embodiments include a method for concentration and purification of salt. NaCl is recovered in a truly Zero Discharge Desalination (i.e., ZDD) process. The ZDD process utilizes reverse osmosis (RO) or nanofiltration (NF) for the primary desalination of groundwater that has high concentration of CaSO4 and utilizes EDM to separately remove calcium and sulfate ions from the RO or NF concentrate so that water recovery can be improved. The recovered NaCl is reused in the EDM. 1. A method for recovering a purified soluble salt , comprising:electrodialysis to recover a salt from an aqueous solution, wherein the aqueous solution comprises a soluble salt contaminated with a salt of limited solubility;recovering a salt from the contaminated aqueous solution; andpurifying the contaminated salt into a purified soluble salt.2. The method of further comprising continuously withdrawing a stream of a batch solution of the soluble salt and the salt of limited solubility.3. The method of wherein a batch of the soluble salt solution is in contact with crystals of the salt of limited solubility.4. The method of further comprising treating a withdrawn stream of a batch solution with a salt recovery device capable of splitting the solution into two streams.5. The method of wherein a first stream of the batch solution is enriched in a soluble salt and a second stream of the batch solution is enriched in a salt of limited solubility.6. The method of wherein the salt recovery device comprises:at least one ion-permeable membrane of the electrodialysis is more permeable to ions of the soluble salt than to ions ...

SHAPED-BASED TECHNIQUES FOR EXPLORING DESIGN SPACES

In various embodiments, a training application generates a trained encoder that automatically generates shape embeddings having a first size and representing three-dimensional (3D) geometry shapes. First, the training application generates a different view activation for each of multiple views associated with a first 3D geometry based on a first convolutional neural network (CNN) block. The training application then aggregates the view activations to generate a tiled activation. Subsequently, the training application generates a first shape embedding having the first size based on the tiled activation and a second CNN block. The training application then generates multiple re-constructed views based on the first shape embedding. The training application performs training operation(s) on at least one of the first CNN block and the second CNN block based on the views and the re-constructed views to generate the trained encoder. 1. A computer-implemented method for generating computational representations for three-dimensional (3D) geometry shapes , the method comprising:for each view included in a first plurality of views associated with a first 3D geometry, generating a view activation based on a first convolutional neural network (CNN) block;aggregating the view activations to generate a first tiled activation;generating a first shape embedding having a fixed size based on the first tiled activation and a second CNN block;generating a first plurality of re-constructed views based on the first shape embedding;performing one or more training operations on at least one of the first CNN block or the second CNN block based on the first plurality of views and the first plurality of re-constructed views to generate a trained encoder; andgenerating a second shape embedding having the fixed size based on the trained encoder.2. The method of claim 1 , wherein aggregating the view activations comprises concatenating the view activations along a single dimension.3. The method ...

SHAPED-BASED TECHNIQUES FOR EXPLORING DESIGN SPACES

In various embodiments, a training application generates a trained encoder that automatically generates shape embeddings having a first size and representing three-dimensional (3D) geometry shapes. First, the training application generates a different view activation for each of multiple views associated with a first 3D geometry based on a first convolutional neural network (CNN) block. The training application then aggregates the view activations to generate a tiled activation. Subsequently, the training application generates a first shape embedding having the first size based on the tiled activation and a second CNN block. The training application then generates multiple re-constructed views based on the first shape embedding. The training application performs training operation(s) on at least one of the first CNN block and the second CNN block based on the views and the re-constructed views to generate the trained encoder. 1. A computer-implemented method for automatically exploring design spaces , the method comprising:for each design included in a plurality of designs, computing a different set of views based on a three-dimensional (3D) geometry associated with the design;for each set of views, computing a different shape embedding based on a trained encoder;in response to receiving a command via a graphical user interface (GUI), determining one or more target designs included in the first plurality of designs based on at least a first shape embedding; anddisplaying the one or more target designs via the GUI, wherein the target designs reflect a preference associated with the first command.2. The computer-implemented method of claim 1 , wherein the plurality of designs is generated via a generative design flow.3. The computer-implemented method of claim 1 , wherein determining the one or more target designs comprises:computing a distance between a first shape embedding and a second shape embedding;determining that a first design included in the plurality of ...

Diazabicyclooctanones as inhibitors of serine beta-lactamases

The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof (I): wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-β-lactamase enzymes, in combination with antibiotics.

ADAPTIVE MULTI-SYMBOL ARITHMETIC CODING

Techniques are presented herein for coding non-binary syntax elements in video coding, including coefficients, by using a symbol-adaptive multi-symbol arithmetic code. These techniques achieve coding gain, reduce or eliminate the deficit of error-resilient versus non-error resilient coding, eliminate the compressed header and reduce the symbol throughput in entropy coding. 1. A method comprising:at an encoder, obtaining an uncompressed video bitstream that includes syntax elements that are to be coded using multi-symbol alphabets such that at least one syntax element of the syntax elements that are to be coded determines a magnitude token level that is at least partially represented by a head part;for each of said at least one syntax element, coding the head part using multi-symbol alphabets to include a magnitude token level and end-of-block (EOB) information; andtransmitting to a decoder an encoded bitstream that includes syntax elements coded with the multi-symbol alphabets.2. The method of claim 1 , wherein the magnitude token level is further represented by a tail part claim 1 , and wherein coding further includes coding the tail part with remaining token level possibilities not represented by the head part.3. The method of claim 2 , wherein coding includes coding the head part with a first multi-valued symbol covering relatively smaller values and coding the tail part with a second multi-valued symbol.4. The method of wherein the magnitude token level indicates a range of magnitude levels.5. The method of claim 1 , wherein coding includes coding a symbol value within a range of magnitude token levels using further syntax elements.6. The methods of claim 1 , wherein coding further includes coding a sign of a symbol value using a sign bit.7. The method of claim 1 , wherein coding includes coding the head part with an odd-number value symbol.8. The method of claim 1 , wherein coding the head part includes coding claim 1 , for a first coefficient claim 1 , an ...

METHOD AND SYSTEM FOR IMAGE PROCESSING

An image processing system comprising: a computer readable medium and at least one processor configured to provide a machine learning architecture for image processing. In particular, keyframes are selected for modification by a visual artist, and the modifications are used for training the machine learning architecture. The modifications are then automatically propagated to remaining frames requiring modification through interpolation or extrapolation through processing remaining frames through the trained machine learning architecture. The generated modified frames or frame portions can then be inserted into an original video to generate a modified video where the modifications have been propagated. Example usages include automatic computational approaches for aging/de-aging and addition/removal of tattoos or other visual effects. 1. A computer system configured to automatically interpolate or extrapolate visual modifications from a set of keyframes extracted from a set of target video frames , the system comprising:a computer processor, operating in conjunction with computer memory maintaining a machine learning model architecture, the computer processor configured to:receive the set of target video frames;identify, from the set of target video frames, the set of keyframes;provide the set of keyframes for visual modification by a human;receive a set of modified keyframes;train the machine learning model architecture using the set of modified keyframes and the set of keyframes, the machine learning model architecture including a first autoencoder configured for unity reconstruction of the set of modified keyframes from the set of keyframes to obtain a trained machine learning model architecture; andprocess one or more frames of the set of target video frames to generate a corresponding set of modified target video frames having the automatically interpolated or extrapolated visual modifications.2. The computer system of claim 1 , wherein the visual modifications ...

Injector including swirl device

An injector includes a needle and a body. The needle is configured to receive fluid from a fluid supply and operable between a first position, in which the fluid is not provided to a target, and a second position, in which the fluid is provided to the target. The needle includes a first needle bore, a second needle bore, and a first connector. The first needle bore is configured to receive fluid from the fluid supply. The second needle bore is aligned with the first needle bore and configured to provide fluid to the fluid supply. The first connector is in fluid communication with the second needle bore. The body includes an end, a first body bore, and a second body bore. The first body bore is configured to receive the needle. The second body bore is positioned to be contiguous with the end.

Style Sheet Driven Virtual Camera for Defining a Navigation Presentation

Some embodiments of the invention provide several novel methods for generating a navigation presentation that displays a device navigating a route on a map. The method of some embodiments uses a virtual camera that, based on detected changes in the navigation context, dynamically modifies the way it captures portions of the map to produce different navigation scenes in the navigation presentation. To generate the navigation scenes, the method of some embodiments (1) identifies different sets of attributes that describe the different navigation contexts at different times during the navigation presentation, and (2) uses these different sets of attributes to identify different styles for operating the virtual camera. In some embodiments, the method uses an identified style to specify the virtual camera's positional attributes, which, in turn, define the portions of the map that the virtual camera identifies for rendering to produce several navigation scenes for a period of time (e.g., until the navigation context changes, or until the navigation presentation ends when the navigation context does not change again). During the navigation presentation, each time the navigation context changes, the identified set of attributes may change. This change, in turn, may cause the method of some embodiments to select a new style for operating the virtual camera. When the style for operating the virtual camera changes, the method of some embodiments modifies the way the virtual camera captures the portion of the map to render. 1. A non-transitory machine readable medium storing a program for execution by at least one processing unit of a mobile device that navigates a route , the program for generating a navigation presentation for a display screen of the mobile device , the program comprising sets of instructions for:defining a first positional relationship between a first coordinate system and a second coordinate system of a plurality of coordinate systems;based on the first ...

ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME

Gelatinous materials combined with the Colloidal Silver additive to formulate an antimicrobial product having cushioning properties. Embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface. 2. The product according to claim 1 , wherein the mat has raised geometric projections on at least one surface of the mat.3. The product according to claim 2 , wherein the mat is an exercise mat.4. The product according to claim 1 , wherein the mat is rolled and joined at opposing ends to form a substantially circular roller.5. The product according to claim 4 , wherein the circular roller has raised geometric projections on the outer surface of the roller.6. The product according to claim 4 , wherein the mat is rolled around an insert.7. The product according to claim 6 , wherein the circular roller has raised geometric projections on the surface of the roller.8. The product according to claim 1 , wherein the mat is a shoe insert. The present invention is a Continuation of U.S. Divisional patent application Ser. No. 15/936,574, filed Mar. 27, 2018, which claims the benefit of U.S. Continuation patent application Ser. No. 14/583,975, filed Dec. 29, 2014, which claims the benefit of U.S. Non-Provisional application Ser. No. 13/151,937, filed Jun. 2, 2011, which claims the benefit of U.S. Provisional Application Ser. No. 61/350,626, filed on Jun. 2, 2010, all are incorporated herein by reference.The present invention is related generally to the field of antimicrobial products, and in particular antimicrobial colloidal silver products.Traditionally, TPE Gels (Thermoplastic Elastomers) are developed by the hydrogenation of tri-block co-polymers of styrene and butadene. The present invention formulation allows for the glass transition of its rubber ...

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. 18.-. (canceled)10. The method of claim 9 , wherein the acute myelocytic leukemia is selected from myeloblastic claim 9 , promyelocytic claim 9 , myelomonocytic claim 9 , monocytic or erythroleukemia leukemia claim 9 , and myelodysplastic syndrome.11. The method of claim 9 , wherein the chronic leukemia is selected from chronic myelocytic leukemia claim 9 , chronic lymphocytic leukemia claim 9 , and hairy cell leukemia.12. The method of claim 9 , wherein the lymphoma is selected from Hodgkin's disease and non-Hodgkin's disease.13. The method of claim 9 , wherein the multiple myeloma is selected from smoldering multiple myeloma claim 9 , nonsecretory myeloma claim 9 , osteosclerotic myeloma claim 9 , and plasma cell leukemia.15. The method of claim 14 , wherein the acute myelocytic leukemia is selected from myeloblastic claim 14 , promyelocytic claim 14 , myelomonocytic claim 14 , monocytic or erythroleukemia leukemia claim 14 , and myelodysplastic syndrome.16. The method of claim 14 , wherein the chronic leukemia is selected from chronic myelocytic leukemia claim 14 , chronic lymphocytic leukemia claim ...

ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME

Gelatinous materials combined with the Colloidal Silver additive to formulate an antimicrobial product having cushioning properties. Embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface. 2. The product according to claim 1 , wherein the mat has raised geometric projections on at least one surface of the mat.3. The product according to claim 2 , wherein the mat is an exercise mat.4. The product according to claim 1 , wherein the mat is rolled and joined at opposing ends to form a substantially circular roller.5. The product according to claim 4 , wherein the circular roller has raised geometric projections on the outer surface of the roller.6. The product according to claim 4 , wherein the mat is rolled around an insert.7. The product according to claim 6 , wherein the circular roller has raised geometric projections on the surface of the roller.8. The product according to claim 1 , wherein the mat is a shoe insert. The present invention is a divisional of U.S. Continuation Patent Application Ser. No. 14/583,975, filed Dec. 29, 2014, which claims the benefit of U.S. Non-Provisional Application Ser. No. 13/151,937, filed Jun. 2, 2011, which claims the benefit of U.S. Provisional Application Ser. No. 61/350,626, filed on Jun. 2, 2010, all are incorporated herein by reference.The present invention is related generally to the field of antimicrobial products, and in particular antimicrobial colloidal silver products.Traditionally, TPE Gels (Thermoplastic Elastomers) are developed by the hydrogenation of tri-block co-polymers of styrene and butadene. The present invention formulation allows for the glass transition of its rubber block below −50° C. thus maintaining its rubbery properties. This material content gel is made up of visco- ...

AIRFOIL RESONANT FREQUENCY TESTING

A resonant frequency testing system for airfoils comprises a broach block, a clamp, an acoustic speaker, a laser vibrometer, and a control processor assembly. The broach block has a slot disposed to receive the airfoil in an airfoil location. The clamp has a torque-actuated shutoff, and is disposed to lock the airfoil in the broach block slot under a fixed clamping force. The acoustic sensor is disposed adjacent the airfoil location to emit sonic pulses, and the laser vibrometer is oriented towards the airfoil location to sense vibration signatures of the airfoil when excited by the sonic pulses. The control processor assembly is configured to control the acoustic speaker and laser vibrometer, to decompose the sensed vibration signatures into resonant frequencies of the airfoil, and to store the resonant frequencies in a digital storage database, correlated with a unique ID corresponding to the airfoil 1. A resonant frequency testing system for an airfoil , the system comprising:a broach block with a slot disposed to receive the airfoil in an airfoil location;a clamp with a torque-actuated shutoff, disposed to lock the airfoil in the broach block slot under a fixed clamping force;an acoustic speaker disposed adjacent the airfoil location to emit sonic pulses;a laser vibrometer oriented towards the airfoil location to sense vibration signatures of the airfoil when excited by the sonic pulses; anda control processor assembly configured to control the acoustic speaker and laser vibrometer, to decompose the sensed vibration signatures into resonant frequencies of the airfoil, and to store the resonant frequencies in a digital storage database, correlated with a unique ID corresponding to the airfoil.2. The resonant frequency testing system of claim 1 , further comprising an ID reader configured scan the airfoil and supply the control processor assembly and digital storage database with the unique ID.3. The resonant frequency testing system of claim 2 , wherein the ID ...

Method and system for measuring envelope efficiency

A method of communicating residential energy efficiency, is provided. The method includes obtaining a data set from a plurality of building structures wherein the data set includes an indoor temperature, an outdoor temperate, and HVAC equipment state information from each of the plurality of building sets. The method further includes determining energy efficiency for each of the plurality of building structures using the indoor temperature, the outdoor temperature and the HVAC equipment state information and displaying energy efficiency for one of the plurality of building structures as a comparison to other of the plurality of building structures. 1. A method of collecting and sharing envelope efficiency of a building structure on a comparative basis , the method comprising:collecting HVAC equipment state information from HVAC equipment associated with the building structure;collecting information about the building structure including the square footage of conditioned space within the building;collecting indoor temperature data and outdoor temperature data associated with the HVAC equipment state information;determining using a processor, a coefficient for the building structure using the indoor temperature data, the outdoor temperature data, and the HVAC equipment state information, the coefficient describing a rate of heat transfer of the building structure per degree temperature difference;determining using the processor, the envelope efficiency for the building structure using the heat loss and the square footage of the conditioned spaced within the building;displaying envelope efficiency for the building structure in comparison to a plurality of other building structures to show the envelope efficiency for the building structure on the comparative basis.2. The method of wherein the envelope efficiency is reported by British Thermal Unit (BTU) per square feet (Sq. Ft.) of conditioned space.3. The method of wherein the plurality of other building structures ...

HANDHELD MOBILE LIGHT SOURCE

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments. 1. A handheld lighting system , comprising:a handheld housing extending from a proximal end to a distal end;an enclosure formed within an internal space of said handheld housing proximate to the distal end thereof, wherein said enclosure comprises a lower portion and an upper portion;a light module having a light source to generate light and a lens optically coupled to said light source, wherein said light module is removably and replaceably disposed in said lower portion of the enclosure; andan adapter removably and replaceably disposed in said upper portion of the enclosure for coupling the light module to a light guide of a device such that the light guide receives the light generated by the light module.2. The handheld lighting system of claim 1 , further comprising a retaining window removably and replaceably received in said upper portion.3. The handheld lighting system of claim 2 , wherein said retaining window comprises an opening for coupling to said adapter.4. The handheld lighting system of claim 1 , further comprising:a power module disposed within said handheld housing and electrically coupled to said light module for providing electrical power thereto.5. The handheld lighting system of claim 4 , wherein said power ...

Allograft tolerance induction

A method inducing chimerism and allograft tolerance by co-infusion of stein/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system. 1. A transplantation method comprising inducing allograft tolerance and chimerism by administering to a host one or more doses of human stem/progenitor-like cells and allogeneic donor cells , wherein said allogneic donor cells are , unprocessed bone marrow , low density bone marrow cells or side population stem cells , to a host , depleting of CD4+ and CD8+ cells and administering a nonmycloablative antineoplastic agent.2. The method of claim 1 , wherein said method also includes the addition of donor tissue wherein said donor tissue is autologous to the donor cells.3. The method of claim 1 , wherein said stem/progenitor-like cells are adipose-derived stem cells.4. The method of claim 1 , wherein said administering of one or more doses of human stem/progenitor-like cells is up to ten (10) days before or after transplantation of tissue or organ.5. The method of claim 1 , wherein said dose of stem/progenitor-like cells is 2×10to 10×10cells/kg.6. The method of claim 1 , wherein administering of said human stem/progenitor-like cells and donor cells is intravenous claim 1 , subcutaneous or intradermal.7. The method of claim 1 , wherein said donor cells are derived from cells selected from the group consisting of cord blood claim 1 , committed progenitor cells claim 1 , differentiated cells claim 1 , vertebral body bone marrow cells claim 1 , marrow cells isolated from ribs claim 1 , iliac crest cells claim 1 , long bone derived marrow cells claim 1 , umbilical cord blood claim 1 , or mobilized stem cells.8. (canceled)9. The method of ...

Allograft tolerance induction

A method inducing chimerism and allograft tolerance by co-infusion of stein/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system. 1. A transplantation method comprising inducing allograft tolerance and chimerism by administering to a host one or more doses of human stem/progenitor-like cells and allogeneic donor cells , wherein said allogneic donor cells are , unprocessed bone marrow , low density bone marrow cells or side population stem cells , to a host , depleting of CD4+ and CD8+ cells and administering a nonmycloablative antineoplastic agent.2. The method of claim 1 , wherein said method also includes the addition of donor tissue wherein said donor tissue is autologous to the donor cells.3. The method of claim 1 , wherein said stem/progenitor-like cells are adipose-derived stem cells.4. The method of claim 1 , wherein said administering of one or more doses of human stem/progenitor-like cells is up to ten (10) days before or after transplantation of tissue or organ.5. The method of claim 1 , wherein said dose of stem/progenitor-like cells is 2×10to 10×10cells/kg.6. The method of claim 1 , wherein administering of said human stem/progenitor-like cells and donor cells is intravenous claim 1 , subcutaneous or intradermal.7. The method of claim 1 , wherein said donor cells are derived from cells selected from the group consisting of cord blood claim 1 , committed progenitor cells claim 1 , differentiated cells claim 1 , vertebral body bone marrow cells claim 1 , marrow cells isolated from ribs claim 1 , iliac crest cells claim 1 , long bone derived marrow cells claim 1 , umbilical cord blood claim 1 , or mobilized stem cells.8. (canceled)9. The method of ...

FIELD CALIBRATION SYSTEM AND METHOD

A calibration system and method having a portable calibration apparatus comprising at least one input/output (I/O) channel to measure or simulate one or more functions of a remote device, The I/O channel being in coupled communication with a microcontroller. The portable calibration apparatus further comprising an internal power supply to provide power to the I/O channel. The internal power supply can also provide power to the microcontroller. The calibration system can also include a user interface to enable selection of at least one of a total number of functions of the I/O channel. 1. A portable calibration apparatus comprising:a plurality of input/output (I/O) channels, wherein each of the plurality of I/O channels to measure or simulate one or more functions of a remote device;a user Interface to enable selection of at least one of a number of total functions of at least one of the plurality of I/O channels; andan internal power supply to provide an operating power to the plurality of I/O channels.2. The portable calibration apparatus of further comprising a central controller to communicate with each of the plurality of I/O channels and the user interface.3. The portable calibration apparatus of further comprising a communication link to enable the communication.4. The portable calibration apparatus of claim 3 , wherein the central controller to allow the user interface to access the number of total functions provided by the at least one of the plurality of I/O channels.5. The portable calibration apparatus of claim 3 , wherein fee central controller to exchange data regarding the one or more functions of a remote device with at least one of the plurality of I/O channels.6. The portable calibration apparatus of claim 5 , wherein the central controller to receive a result of the measurement or simulation of the functionality from the at least one of the plurality of I/O channels claim 5 , andwherein the central controller to document the result.7. The portable ...

METHODS AND DEVICES FOR MEASURING CONDUCTIVITY OF FLUIDS

A sensor for detecting the breakthrough of hardness in a water softener measures a change in the conductivity of elongated cation-exchange material in contact with the treated water. 1. A sensor for measuring conductivity comprising a continuous ion-exchange material and a resistor , wherein the continuous ion-exchange material is in electrical series with the resistor and voltage across the ion-exchange material is proportional to the electrical conductivity of the ion-exchange material.2. The sensor of claim 1 , wherein the resistor is a thermistor.3. The sensor of claim 1 , further comprising one or more switches configured to be engaged periodically in a manner to cause an electrical current to flow in either of two directions in the ion-exchange material or to remove electrical current flow through the ion-exchange material.4. The sensor of whereby said voltage is latched so as to store a value that is proportional to said conductivity.5. A sensor for detecting a change in ionic composition of a fluid comprising:(i) a first non-conductive plate and a second non-conductive plate configured to form a cavity through which a test fluid flows,(ii) a continuous ion-exchange material positioned within the cavity configured to be in contact with the fluid,(iii) a first electrode in contact with a first portion of the ion-exchange material and a second electrode in contact with a second portion of the ion-exchange material, the first and second electrode being separated by a predetermined distance, and(iv) a device coupled to the ion-exchange material configured for measuring the electrical conductivity across the ion-exchange material.6. The sensor of claim 5 , wherein the continuous ion-exchange material is a membrane or fiber.7. The sensor of claim 6 , wherein the ion-exchange membrane is a cation-exchange membrane.8. The sensor of claim 6 , wherein the continuous ion-exchange material is an anion-exchange membrane.9. The sensor of claim 5 , wherein the non- ...

COMPRESSED DOMAIN DATA CHANNEL FOR WATERMARKING, SCRAMBLING AND STEGANOGRAPHY

A computer-implemented method is provided for processing a video stream in the compressed domain for watermarking, scrambling and other applications. Syntax elements are generated for input video as part of a video compression process. The syntax elements are entropy coded with an arithmetic entropy encoding process to produce a compressed bitstream for the input video. Regions of frames and related syntax elements of the input video are identified as candidates for modification. Based on metadata associated with a particular user, the syntax elements, the regions, and entropy coding state of the arithmetic entropy encoding process, bytes of the input video are changed to generate a modifying bitstream that is unique to the particular user; and modifying the compressed bitstream using the modifying bitstream to produce a decodable bitstream for the input video. 1. A computer-implemented method comprising:obtaining uncompressed input video;generating syntax elements for the input video as part of a video compression process;entropy coding the syntax elements with an arithmetic entropy encoding process to produce a compressed bitstream for the input video;identifying regions of frames and related syntax elements of the input video which are candidates for modification;based on metadata associated with a particular user, the syntax elements, the regions, and entropy coding state of the arithmetic entropy encoding process, changing bytes of the input video to generate a modifying bitstream that is unique to the particular user; andmodifying the compressed bitstream using the modifying bitstream to produce a decodable bitstream for the input video.2. The method of claim 1 , wherein the metadata is descriptive of a watermarking signal unique to the particular user.3. The method of claim 1 , wherein changing bytes of the input video is performed to produce a unique modifying bitstream for each of a plurality of users based on unique metadata associated with each of the ...

Method and system for measuring envelope efficiency

A method of communicating residential energy efficiency, is provided. The method includes obtaining a data set from a plurality of building structures wherein the data set includes an indoor temperature, an outdoor temperate, and HVAC equipment state information from each of the plurality of building sets. The method further includes determining energy efficiency for each of the plurality of building structures using the indoor temperature, the outdoor temperature and the HVAC equipment state information and displaying energy efficiency for one of the plurality of building structures as a comparison to other of the plurality of building structures. 1. A method of collecting and sharing energy efficiency on a comparative basis , the method comprising:collecting HVAC equipment state information;associating indoor temperature data and outdoor temperature data with the HVAC equipment state information;determining using a processor, energy efficiency for the building structure using the indoor temperature data, the outdoor temperature data, and the HVAC equipment state information;displaying energy efficiency for the building structure in comparison to a plurality of other building structures to show the energy efficiency for the building structure on the comparative basis.2. The method of wherein the energy efficiency is reported by British Thermal Unit (BTU) per square feet (Sq. Ft.) of living space.3. The method of wherein the plurality of other building structures includes building structures from across the country.4. The method of wherein the plurality of other building structures have a common design temperature.5. The method of wherein the energy efficiency for the building structure comprises a percentile ranking for the building structure within a set comprising the building structure and the plurality of other building structures.6. The method of wherein the energy efficiency is reported both by BTU per Sq. Ft. of living space and as a percentile ranking for ...

ENCODING AND DECODING OF LIVE-STREAMED VIDEO USING COMMON VIDEO DATA SHARED BETWEEN A TRANSMITTER AND A RECEIVER

A first endpoint device has access to common video data including common video frames and encoded common video data having the common video frames encoded therein. The encoded common video data is downloaded to a second endpoint device. After, or during, the downloading of the encoded common video data, live video frames are played in a play order. The live video frames are encoded in the play order into encoded live video frames. To encode the live video frames, each live video frame is predicted based on a previous live video frame that has been encoded and a common video frame from the common video data that has been downloaded in the encoded common video data. The encoded live video frames include indications of the previous live video frame and the common video frame used to encode each encoded live video frame are transmitted to the second endpoint device. 1. A method comprising: downloading to a second endpoint device the encoded common video data;', 'after, or during, the downloading of the encoded common video data to the second endpoint device, playing live video frames in a play order;', 'encoding the live video frames in the play order into encoded live video frames, wherein the encoding includes, for each live video frame, predicting the live video frame based on a previous live video frame that has been encoded and a common video frame from the common video data that has been downloaded in the encoded common video data; and', 'transmitting to the second endpoint device the encoded live video frames including indications of the previous live video frame and the common video frame used to encode each encoded live video frame., 'at a first endpoint device having access to common video data including common video frames and encoded common video data having the common video frames encoded therein2. The method of claim 1 , wherein the encoding further comprises claim 1 , for each live video frame: prior to the predicting claim 1 , selecting the common video ...

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds of Formula (I) 8. A compound of selected from:5-Cyclopentyl-1-{3-[3-(dimethylcarbamoyl)-2-fluorophenyl]phenyl}-1H-pyrazole-4-carboxylic acid1-{3-[3-(Dimethylcarbamoyl)-2-fluorophenyl]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid1-(3-{3-[Cyclopentyl(methyl)carbamoyl]-2-fluorophenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-(3-{2-fluoro-3-[methyl(2-methylpropyl)carbamoyl]phenyl}phenyl)-1H-pyrazole-4-carboxylic acid1-(3-{3-[Cyclohexyl(methyl)carbamoyl]-2-fluorophenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-{3-[3-(3,3-dimethylpiperidine-1-carbonyl)-2-fluorophenyl]phenyl}-1H-pyrazole-4-carboxylic acid1-{3-[3-(azepane-1-carbonyl)-2-fluorophenyl]phenyl}-5-cyclopropyl-1H-pyrazole-4-carboxylic acid1-(3-{3-[Bis(cyclopropylmethyl)carbamoyl]-2-fluorophenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-(3-{3-[(cyclopropylmethyl)(propyl)carbamoyl]-2-fluorophenyl}phenyl)-1H-pyrazole-4-carboxylic acid1-{3-[3-(Azepane-1-carbonyl)phenyl]phenyl}-5-cyclopropyl-1H-pyrazole-4-carboxylic acid1-{3-[3-(propan-2-yloxy)phenyl]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid1-(3-{3-[(Cyclopentylmethyl)(methyl)carbamoyl]-2-fluorophenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid5-[(cis)-3-Acetamidocyclopentyl]-1-{3-[2-fluoro-3-(propan-2-yloxy)phenyl]phenyl}-1H-pyrazole-4-carboxylic acid (cis racemate)1-(3-{3-[(Cyclopentylmethyl)(cyclopropylmethyl)carbamoyl]-2-fluorophenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid1-(3-{2-Chloro-3-[(cyclopropylmethyl)(propyl)carbamoyl]phenyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-(3-{3-[(cyclopropylmethyl)(propyl)carbamoyl]-2-methylphenyl}phenyl)-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-{3-[2-fluoro-3-(2-propylpiperidine-1-carbonyl)phenyl]phenyl}-1H-pyrazole-4-carboxylic acid5-Cyclopropyl-1-(3-({2-fluoro-3-[3-(trifluoromethyl)piperidine-1-carbonyl]phenyl}phenyl)- ...

SYSTEMS AND METHODS FOR SENSOR STREAMER TANGLE DETECTION

Methods and related systems are disclosed. In an embodiment, a method includes determining a distance between a tow vessel and a predetermined point along a line being towed by the tow vessel. In addition, the method includes adjusting a length of the line from the tow vessel. Further, the method includes determining a change in the distance a predetermined amount of time after adjusting the length of the line. Still further, the method includes determining whether a difference between the change in the distance and the adjustment of the length exceeds a threshold value. 1. A method comprising:determining a distance between a tow vessel and a predetermined point along a line being towed by the tow vessel;adjusting a length of the line from the tow vessel;determining a change in the distance a predetermined amount of time after adjusting the length of the line; anddetermining whether a difference between the change in the distance and the adjustment of the length exceeds a threshold value.2. The method of claim 1 , wherein the line is a sensor streamer;wherein the adjusting comprises paying out a payout length of the line;wherein the determining whether the difference between the change in the distance and the adjustment of the length exceeds a threshold value comprises determining whether a difference between the change in the distance and the payout length exceeds a threshold value.3. The method of claim 2 , further comprising determining the predetermined amount of time based on at least one selected from the group consisting of:the length of the sensor streamer deployed from the tow vessel;an amount of tension in the sensor streamer;an amount of current experienced by the sensor streamer;a change in heading of the tow vessel;a payout rate of the sensor streamer; anda speed of the tow vessel.4. The method of claim 2 , further comprising determining the predetermined amount of time based on a tension in the sensor streamer deployed from the tow vessel; ...

SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS

Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. 2. The compound of claim 1 , wherein Ris optionally substituted heteroaryl or heterocyclyl selected from 1H-pyrazolyl claim 1 , 1H-imidazolyl claim 1 , 1 claim 1 ,2-oxazolyl claim 1 , pyridinyl claim 1 , 1H-indolyl claim 1 , 2H-indazolyl claim 1 , 4 claim 1 ,5 claim 1 ,6 claim 1 ,7-tetrahydro-2H-indazolyl claim 1 , 1H-benzimidazolyl claim 1 , imidazo[2 claim 1 ,1-b][1 claim 1 ,3]thiazolyl claim 1 , pyrazolo[1 claim 1 ,5-a]pyridinyl claim 1 , pyrazolo[1 claim 1 ,5-c]pyrimidinyl claim 1 , imidazo[1 claim 1 ,2-a]pyridinyl claim 1 , 5 claim 1 ,6 claim 1 ,7 claim 1 ,8-tetrahydroimidazo[1 claim 1 ,2-a]pyridinyl claim 1 , 1H-imidazo[4 claim 1 ,5-b]pyridinyl claim 1 , 1H-imidazo[4 claim 1 ,5-c]pyridinyl claim 1 , 4 claim 1 ,5 claim 1 ,6 claim 1 ,7-tetrahydro-3H-imidazo[4 claim 1 ,5-c]pyridinyl claim 1 , imidazo[1 claim 1 ,2-a]pyrazinyl claim 1 , imidazo[1 claim 1 ,2-a]pyrimidinyl claim 1 , 7H-purinyl or quinolinyl.3. The compound of claim 2 , wherein Ris optionally substituted heteroaryl selected from 1H-pyrazolyl claim 2 , 1H-indolyl claim 2 , 1H-benzimidazolyl claim 2 , pyrazolo[1 claim 2 ,5-a]pyridinyl claim 2 , imidazo[1 claim 2 ,2-a]pyridinyl claim 2 , 1H-imidazo[4 claim 2 ,5-b]pyridinyl claim 2 , imidazo[1 claim 2 ,2-a]pyrazinyl or imidazo[1 claim 2 ,2-a]pyrimidinyl.4. A compound or a form thereof selected from the group consisting of:N-(4-methoxyphenyl)-2-(2-methyl-1H-benzimidazol-1-yl)pyrimidin-4-amineN-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-4-amine2-(2-methylimidazo[1,2-a]pyridin-3-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amineN-(4-methoxyphenyl)-2-(2-methylimidazo[1,2-a]pyridin-3-yl) ...

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators. 2. The compound or pharmaceutically acceptable salt according to wherein A is —C(O)ORand Ris hydrogen claim 1 , —Calkyl-N(R) claim 1 , —(CH)-morpholinyl claim 1 , —(CH)-imidazolyl claim 1 , —(CH)-pyrolidinyl claim 1 , or —(CH)-piperidyl.3. The compound or pharmaceutically acceptable salt according to wherein A is —C(O)OH.4. The compound or pharmaceutically acceptable salt according to wherein Ris:{'sub': 1-3', '1-3, 'phenyl substituted by one, two, or three groups independently selected from —CN, —F, —Cl, Calkyl, and —O—Calkyl;'}{'sub': 1-3', '1-3, 'benzotriazolyl substituted by one, two, or three groups independently selected from —O—Calkyl and Calkyl; or'}{'sub': 2', '2', '1-3', '2, '—(CH)-triazolyl substituted by one or two groups independently selected from Calkyl or —CH-phenyl.'}5. The compound or pharmaceutically acceptable salt according to wherein Ris benzotriazolyl substituted by one or two groups independently selected from —O—Calkyl and Calkyl.7. The compound or pharmaceutically acceptable salt according to wherein Ris hydrogen claim 1 , —Cl claim 1 , Calkyl claim 1 , or —CF.8. The compound or pharmaceutically acceptable salt according to wherein each Ris hydrogen.10. The compound according to selected from the group consisting of:3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((5-methyl-1,1-dioxido-4,5-dihydrobenzo[f][1,2,5]thiadiazepin-2(3H)-yl)methyl)phenyl)propanoic acid;3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((5-methyl-1,1-dioxido-4,5-dihydrobenzo[f][1,2,5]thiadiazepin-2(3H)-yl)methyl)phenyl)propanoic acid;3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)propanoic acid;3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((3-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5] ...

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. 18-. (canceled)10. The use of claim 9 , wherein the acute myelocytic leukemia is selected from myeloblastic claim 9 , promyelocytic claim 9 , myelomonocytic claim 9 , monocytic or erythroleukemia leukemia or myelodysplastic syndrome.11. The use of claim 9 , wherein the chronic leukemia is selected from chronic myelocytic leukemia claim 9 , chronic lymphocytic leukemia or hairy cell leukemia.12. The use of claim 9 , wherein the lymphoma is selected from Hodgkin's disease or non-Hodgkin's disease.13. The use of claim 9 , wherein the multiple myeloma is selected from smoldering multiple myeloma claim 9 , nonsecretory myeloma claim 9 , osteosclerotic myeloma or plasma cell leukemia.15. The use of claim 14 , wherein the acute myelocytic leukemia is selected from myeloblastic claim 14 , promyelocytic claim 14 , myelomonocytic claim 14 , monocytic or erythroleukemia leukemia or myelodysplastic syndrome.16. The use of claim 14 , wherein the chronic leukemia is selected from chronic myelocytic leukemia claim 14 , chronic lymphocytic leukemia or hairy cell leukemia.17. The use of claim 14 , wherein the lymphoma ...

HYBRID OPEN-LOOP/CLOSED-LOOP COMPRESSION OF PICTURES

In a method of video coding, in which a difference is formed between input picture values and picture prediction values and that difference is transforming with a DCT, the picture prediction is formed as: P=(1−c)P+CPwhere Pis a closed loop predictor which is restricted to prediction values capable of exact reconstruction in a downstream decoder and Pis a spatial predictor which is not restricted to prediction values capable of exact reconstruction. The factor can vary from zero to unity depending on a variety of parameters. 1. A method of compression coding , the method comprising the steps of:forming a difference between input picture values and picture prediction values; and transforming the difference in a transform;{'sup': c', 'o', 'o', 'o, 'wherein a picture prediction P is formed by the combination of a predictor Pwhich is a temporal predictor or a spatial predictor and which is restricted to prediction values capable of exact reconstruction in a downstream decoder and a predictor Pwhich is not restricted to prediction values capable of exact reconstruction in a downstream decoder, the predictor Pbeing a spatial predictor with the transform being a spatial transform or a temporal transform or the predictor Pbeing a temporal predictor with the transform being a temporal transform.'}2. The method according to claim 1 , wherein said picture prediction P comprises a weighted sum of the respective outputs of the predictor Pand the predictor Pof the form:{'br': None, 'i': P=aP', '+bP, 'sup': c', 'o}3. The method according to claim 1 , wherein the relative weighting of the predictor Pand the predictor Pvaries with picture content.4. The method according to claim 1 , wherein the picture prediction P is formed as:{'br': None, 'i': P=', 'c', 'P', '+cP, 'sup': c', 'o, '(1−)'}where c is a selectable weighting factor variable between zero and unity.5. The method according to claim 4 , wherein metadata indicating the weighting factor c is signalled in a bitstream.6. The ...

Dynamic Dependency Breaking in Data Encoding

In one embodiment, a method includes selecting a first video encoding task of the plurality of video encoding tasks, the first video encoding task having a first dependency upon a second video encoding task of the plurality of video encoding tasks. The method includes determining whether to break the first dependency and performing the first video encoding task based on the determination of whether to break the first dependency.

CLINICAL DECISION MODEL

An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound. 17-. (canceled)8. A method of generating a model predicting a personalized risk of disease for a subject , comprising: i) the training database comprises a set of reference clinical parameters obtained from a plurality of subjects having known disease outcomes, and', 'ii) the fully unsupervised BBN model comprises a directed acyclic graph including a plurality of nodes, wherein each node includes at least two bins, each bin representing a value range of a clinical parameter associated with that node, and wherein each of the nodes comprises data identifying at least one conditional dependence relationship between a known disease outcome and the clinical parameter associated with that node;, 'a) generating, by a processor, at least one fully unsupervised Bayesian Belief Network (BBN) model using data from a training database, wherein'}b) inputting a set of clinical parameters into the fully unsupervised BBN model, wherein the set comprises clinical parameters of a sample ...

Style Sheet Driven Virtual Camera for Defining a Navigation Presentation

Some embodiments of the invention provide several novel methods for generating a navigation presentation that displays a device navigating a route on a map. The method of some embodiments uses a virtual camera that, based on detected changes in the navigation context, dynamically modifies the way it captures portions of the map to produce different navigation scenes in the navigation presentation. To generate the navigation scenes, the method of some embodiments (1) identifies different sets of attributes that describe the different navigation contexts at different times during the navigation presentation, and (2) uses these different sets of attributes to identify different styles for operating the virtual camera. In some embodiments, the method uses an identified style to specify the virtual camera's positional attributes, which, in turn, define the portions of the map that the virtual camera identifies for rendering to produce several navigation scenes for a period of time (e.g., until the navigation context changes, or until the navigation presentation ends when the navigation context does not change again). During the navigation presentation, each time the navigation context changes, the identified set of attributes may change. This change, in turn, may cause the method of some embodiments to select a new style for operating the virtual camera. When the style for operating the virtual camera changes, the method of some embodiments modifies the way the virtual camera captures the portion of the map to render. 1. A non-transitory machine readable medium storing a program for execution by at least one processing unit , the program for generating a navigation presentation for display on a device that navigates to a destination along a map , the program comprising sets of instructions for:identifying, during the navigation to the destination, a set of attributes describing a current context of the navigation;using the identified set of attributes to identify a style ...

Techniques for Interactive Region-Based Scalability

Techniques are provided herein for optimizing encoding and decoding operations for video data streams. An encoded video data stream is received, and select image segments of the encoded video data stream are identified. Each of the select image segments is an independently decodable portion of the encoded video data stream. Enhanced layer decoding operations are performed on each of the select image segments of the encoded video data stream to obtain an enhanced decoded output for the select image segments. Base layer decoding operations on each of the select image segments of the encoded video data stream are performed to obtain a base layer decoded output for the select image segments. 1. A method comprising:receiving an encoded video data stream;identifying select image segments of the encoded video data stream, wherein each of the select image segments is an independently decodable portion of the encoded video data stream;performing enhanced layer decoding operations on each of the select image segments of the encoded video data stream to obtain an enhanced decoded output for the select image segments; andperforming base layer decoding operations on each of the select image segments of the encoded video data stream to obtain a base layer decoded output for the select image segments.2. The method of claim 1 , further comprising performing base layer decoding operations on every image segment of the encoded video data stream.3. The method of claim 1 , wherein identifying comprises receiving from a device that generates the encoded video data stream an indication of the select image segments.4. The method of claim 3 , wherein receiving comprises receiving the indication of the select image segments that represents at least one region of interest of the encoded video data stream.5. The method of claim 4 , wherein identifying comprises identifying the select image segments of the region of interest that identifies a spatial location for enhancement in an image of the ...

USE OF ANTI-PD-1 ANTIBODY IN COMBINATION WITH ANTI-CD27 ANTIBODY IN CANCER TREATMENT

This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof. 1. A method for treating a subject afflicted with a tumor comprising administering to the subjectan antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“anti-PD-1 antibody or antigen-binding portion thereof”) at a dose of 240 mg in combination withan antibody or an antigen-binding portion thereof that specifically binds to CD27 (“anti-CD27 antibody or antigen-binding portion thereof”) at a dose of 3 mg/kg.2. The method of claim 1 , wherein the tumor is colorectal cancer claim 1 , rectal cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , melanoma claim 1 , ovarian cancer claim 1 , head and neck cancer claim 1 , glioblastoma claim 1 , renal cell carcinoma claim 1 , or any combination thereof.3. A method for treating a subject afflicted with a tumor comprising administering to the subjectan antibody or antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“anti PD-1 antibody or antigen-binding portion thereof”) at a dose of 240 mg in combination withan antibody or an antigen-binding portion thereof that specifically binds to CD27 (“anti-CD27 antibody or antigen-binding portion thereof”) at a dose of 0.3 mg/kg.4. The method of claim 1 , wherein the anti-PD-1 antibody or antigen-binding portion thereof cross-competes with nivolumab for binding to human PD-1.5. The method of claim 1 , wherein the anti-CD27 antibody or antigen-binding portion thereof cross-competes with varlilumab for binding to human CD27.6. The method of claim 1 , wherein:(i) the anti-PD-1 antibody is nivolumab;(ii) ...

LOW-COMPLEXITY METHOD FOR GENERATING SYNTHETIC REFERENCE FRAMES IN VIDEO CODING

Presented herein are techniques for a low-complexity process of generating an artificial frame that can be used for prediction. At least a first reference frame and a second reference frame of a video signal are obtained. A synthetic reference frame is generated from the first reference frame and the second reference frame. Reference blocks from each of the first reference frame and the second reference frame are combined to derive an interpolated block of the synthetic reference frame. 1. A method comprising:obtaining at least a first reference frame and a second reference frame of a video signal; dividing the synthetic reference frame into a plurality of blocks, and further dividing the plurality of blocks into a plurality of sub-blocks;', determining that motion estimation cannot be bypassed;', 'in response to determining that the motion estimation cannot be bypassed, for each of the plurality of blocks in raster order, determining candidate motion vectors from lower layer blocks and from neighbor blocks; and', 'identifying, for each sub-block, a primary motion vector in a farther one of the first reference frame and the second reference frame;, 'searching for motion vectors in the first reference frame and the second reference frame for each of the plurality of blocks in the synthetic reference frame, wherein the searching comprises, 'deriving motion vector information for each of the plurality of blocks in the synthetic reference frame from motion vectors identified in each of the first reference frame and the second reference frame, including deriving a secondary motion vector in a nearer one of the first reference frame and the second reference frame from the primary motion vector by scaling the primary motion vector to an appropriate scale, wherein the primary motion vector is determined to pixel accuracy and the secondary motion vector is rounded to achieve a same level of accuracy as the primary motion vector;', 'identifying reference blocks in each of the ...

HANDHELD MOBILE LIGHT SOURCE

In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments. 1. A handheld lighting system , comprising:a handheld housing extending from a proximal end to a distal end,a light module removably and replaceably disposed in said housing, said light module having a hollow chamber extending from a proximal end to a distal end, said light module further comprising a light source and a lens optically coupled to said light source disposed in said hollow chamber,said light module having an adapter disposed at said distal end of said hollow chamber for coupling the light module to a light guide such that the light guide receives the light generated by the light module, anda power module disposed within the housing and electrically coupled to said light module for providing electrical power thereto.2. The handheld lighting system of claim 1 , wherein said adapter is removable and replaceable.3. The handheld lighting system of claim 1 , wherein said light module comprises a pair of electrical conductors protruding through an internal wall of said housing for electrically connecting the light module to said power module.4. The handheld lighting system of claim 3 , wherein said housing comprises a first enclosure extending from said internal wall to said distal end for receiving said light module.5. The ...

LATENCY MITIGATION THROUGH INTELLIGENT EXTRAPOLATION IN MULTIMEDIA SYSTEMS

In one embodiment, a device de-multiplexes a stream of multimedia data into first and second media streams. The device determines that a portion of the first media stream is missing for co-presentation with a corresponding portion of the second media stream due to a present latency condition. The device associates the corresponding portion of the second media stream with a previously received portion of the second media stream. The device generates media data for the first media stream for co-presentation with the corresponding portion of the second media stream in lieu of the missing portion of the first media stream, based on a previously received portion of the first media stream associated with the previously received portion of the second media stream. The device provides the generated media data and the corresponding portion of the second media stream for co-presentation by one or more user interfaces. 1. A method comprising:de-multiplexing, by a device in a network, a stream of multimedia data into first and second media streams, wherein the first media stream is a video stream and the second media stream is an audio stream;determining, by the device, that a portion of the first media stream is missing for co-presentation with a corresponding portion of the second media stream due to a present latency condition;associating, by the device, the corresponding portion of the second media stream with a previously received portion of the second media stream; identifying, by the device, an audio feature from the corresponding portion of the audio stream; and', 'matching, by the device, the audio feature to an audio feature from the previously received portion of the audio stream; and', 'selecting, by the device, the media data as a portion of the video stream that was co-presented by the one or more user interfaces with the previously received portion of the audio stream; and, 'generating, by the device, media data for the first media stream for co-presentation with ...

Biodegradable polyester with improved molding characteristics and its production

The invention relates to a method for preparing a biodegradable aliphatic polyester, which comprises polymerization of a precursor of the polyester in the presence of a polyesterification catalyst in an amount of up to 0.1% by weight, based on the weight of the cyclic precursor, and a co-catalyst comprising glycerol or butyrolactone in a weight proportion of not more than three times that of the catalyst. The invention also relates to the use of the resulting biodegradable aliphatic polyester in polymer processing, such as injection molding or compression/press molding.

Biodegradable polyester with improved moulding characteristics and its production

The invention relates to a method for preparing a biodegradable aliphatic polyester or polycarbonate, which comprises polymerisation of a precursor of the polyester such as lactide in the presence of a polyesterification catalyst in an amount of up to 0.1% by weight, based on the weight of the cyclic precursor, and a co-catalyst comprising glycerol or butyrolactone in a weight proportion of not more than three times that of the catalyst. The invention also relates to the use of the resulting biodegradable aliphatic polyester in polymer processing, such as injection moulding or compression/press moulding.

Hydrovisbreaking process for hydrocarbon containing feed streams

At least one decomposable molybdenum compound selected from the group consisting of molybdenum dithiophosphates and molybdenum dithiocarbamates is mixed with a hydrocarbon-containing feed stream. The hydrocarbon-containing feed stream containing such decomposable molybdenum compound is then contacted in a hydrovisbreaking process with hydrogen under suitable hydrovisbreaking conditions.

Method and apparatus for creating a personal sports lesson

A system and method for creating a personal sports lesson captures video file of a sport motion of a person, for instance a baseball batting swing from start to finish. Various part of the body positions are marked in each of the selected video swing frames and analyzed against a knowledge base and those of a professional player for providing an interactive personal lesson.

Method of chromizing a workpiece by applying a coating containing chromium particles onto a ceramic carrier, positioning the carrier proximate the workpiece, and heating both carrier and workpiece to diffuse chromium particles into the workpiece

An improved method of diffusion coating a workpiece, such as ferritic tubing employing a ceramic carrier provided with a diffusion composition. The diffusion composition includes a diffusion element such as chromium, silicon, aluminum, and boron. The carrier is subjected to an elevated diffusion temperature in a controlled environment to diffusion coat either the external or internal surface of the workpiece.

Method for aluminizing a ferritic workpiece by coating it with an aqueous alumina slurry, adding a halide activator, and heating

An improved method for aluminizing a ferritic material by forming an aqueous aluminum slurry composition, applying the aqueous aluminum slurry composition to the ferritic material to form a coating, adding a halide activator to the coated ferritic material and heating the coated ferritic material to a temperature of about 1275° F. to about 1300° F. for approximately 24 hours. The use of the lower temperature thermal cycle minimizes the change in the mechanical properties of a steel substrate.

Production of biodegradable polyester, catalyst system therefor, and biodegradable polyester produced thereby

(57)【要約】 【課題】 ＰＬＡの重合反応を速めてＰＬＡの分解を抑 制する触媒系、成形に好適な生分解性ポリマー、このよ うなポリマーを製造できる方法、及び当該生分解性ポリ エステルから製造される生分解性製品又は生分解性成形 品。 【解決手段】 ポリエステル原料を触媒存在下で重合し て生分解性ポリエステルを製造する方法において、グリ セリン、ブチロラクトン、ポリエチレングリコール、ベ ンジルアルコール、及びｍ−クレゾールよりなる群から 選択される少なくとも１種を共触媒として用いる。前記 触媒は、カルボン酸の金属塩、カルボン酸の有機金属 塩、金属酸化物及び金属ハロゲン化物よりなる群から選 択される少なくとも１種であることが好ましい。

Chemical compounds

The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.

Engine breather assembly with oil drain back

ABSTRACT OF THE DISCLOSURE A breather assembly for a combustion engine which conserves oil by condensing oil vapor from the engine and returning the oil to the crankcase. The breather assembly is mounted to the crankcase cover and includes a drain tube extending into a low pressure area of the crankcase. The breather includes a baffled interior chamber with an inlet opening at its lower end having a valving mechanism biased towards the closed position. Vapor travels through the valve into the chamber and over a baffle wall into an outer annulus. Breather holes at the bottom of the annulus allow gases to escape. Oil is condensed as the vapor travels up the inner chamber. A vacuum created by the crankcase through the drain back tube causes the condensed oil to flow back into the crankcase. In a preferred embodiment, the breather assembly is molded using a polyurethane material.

Method for chromizing of boiler components

An improved method of chromizing the surface of a ferritic boiler component. An aqueous coating composition is applied to the surface to be chromized, which includes at least 10% by weight of chromium, at least 12% by weight alumina, a binder of ammonium alginate or methyl cellulose, and a halide activator, and in which the weight ratio of chromium to water is greater than 0.7. Alternative embodiments involve the application of a halide activator over the top of a previously applied and dried coating that is lacking said halide activator, as well as to the application of multiple layer single component slurry coatings.

Diazabicyclooctanones as inhibitors of serine beta-lactamases

The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof (I): wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-ß-lactamase enzymes, in combination with antibiotics.

Sprayed in place pipe lining apparatus and method thereof

A method and apparatus for applying a liner to a pipe is disclosed. The apparatus includes a base assembly having a plurality of guide rails and a shuttle plate attached thereto. The apparatus also includes a motor module attached to an end of the base assembly. An extension arm is connected to a top surface of the shuttle plate. The extension arm has a spray head assembly attached at an opposite end thereof. The extension arm and spray head assembly will move relative to the base assembly of the apparatus. A fast cure coating will be applied via the spray head assembly to the interior surface of a pipe being rehabilitated. The spray head assembly will have an air blow off mechanism therein thus allowing for the tip of the spray head assembly to stay relatively clog free during the fast cure coating operation of the apparatus. The methodology also includes an oscillation system wherein the spray head assembly will move relative to the base assembly thus creating an over lapping pattern for the spray coating being applied to the interior surface of the pipeline. This oscillation system will allow for a more uniform coating to be applied.

Method for diffusion coating of metal objects employing ceramic carrier provided with diffusion composition

An improved method of diffusion coating a workpiece, such as ferritic tubing employing a ceramic carrier provided with a diffusion composition. The diffusion composition includes a diffusion element such as chromium, silicon, aluminum, and boron. The carrier is subjected to an elevated diffusion temperature in a controlled environment to diffusion coat either the external or internal surface of the workpiece.

Improvements to air compressors

Administration of carboline derivatives useful in the treatment of cancer and other diseases

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.