13-06-2023 дата публикации
Номер: CN116259372A
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The invention discloses a lactobacillus bulgaricus and streptococcus thermophilus interaction prediction and screening method. The method comprises the following steps: S1, calculating respective similarities of lactobacillus bulgaricus and streptococcus thermophilus; s2, utilizing a Laplacian regularization least square method to calculate a Bazao-thermophile pre-estimated interaction score and a thermophile-Bazao pre-estimated interaction score; s3, training and evaluating the model, namely training and evaluating the known Pauty and Addition thermophilic interaction matrix A in the step S2 by adopting a leave-one method, and determining an optimal model; s4, adjusting and optimizing the model; s5, retraining the model by using the optimal parameters, storing the model, performing interaction prediction on a plurality of strain combinations by using the obtained model, and screening out a strain combination with high interaction possibility; and S6, verifying the fermentation time of ...
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