11-05-2017 дата публикации
Номер: US20170129891A1
Автор:
Doris Stoermer,
Joseph F. Dellaria, JR.,
David T. Amos,
Bernhard M. Zimmermann,
Luke T. Dressel,
Jason D. Bonk,
Matthew R. Radmer,
STOERMER DORIS,
DELLARIA JR JOSEPH F,
AMOS DAVID T,
ZIMMERMANN BERNHARD M,
DRESSEL LUKE T,
BONK JASON D,
RADMER MATTHEW R,
Stoermer Doris,
Dellaria, JR. Joseph F.,
Amos David T.,
Zimmermann Bernhard M.,
Dressel Luke T.,
Bonk Jason D.,
Radmer Matthew R.
Принадлежит:
Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed. 3. The compound or salt of wherein p is 0.4. The compound or salt of wherein m is 1.5. The compound or salt of wherein Z is selected from the group consisting of a bond and Calkylene.6. The compound or salt of wherein Z is —(CH)-A′—(CH)—.7. The compound or salt of wherein A′ is —O—.8. The compound or salt of wherein A′ is —N(R)— or —N(Q-R)—.9. The compound or salt of wherein Q is —S(O)— and Ris Calkyl.12. The compound or salt of wherein R′ is hydroxy.13. The compound or salt of wherein Ris hydrogen claim 2 , Calkyl claim 2 , HO—Calkylenyl claim 2 , or Calkyl-O—Calkylenyl.14. The compound or salt of claim 2 , wherein R′ is selected from the group consisting of —NHand —NH-Q-R claim 2 , wherein:{'sub': 2', '6', '8', '8', '1-4, 'Q is selected from the group consisting of —C(O)—, —C(O)—O—, —S(O)—, and —C(R)—N(R)—, wherein Ris selected from hydrogen and Calkyl; and'}{'sub': '4', 'Ris alkyl, aryl, arylalkylene, heteroaryl, and heterocyclyl, wherein the aryl group can be unsubstituted or substituted by acetylamino, alkyl, alkoxy, cyano, and halogen.'}15. The compound or salt of wherein:{'sub': 2', '4, 'claim-text': [{'sub': '1-2', 'X is Calkylene;'}, {'sub': 0-2', '2', '8', '6', '6', '6', '8', '6', '8', '6', '8', '6', '9, 'Y is selected from the group consisting of —S(O)—, —S(O)—N(R)—, —C(R)—, —C(R)—O—, —O—C(R)—, —O—C(O)—O—, —N(R)-Q-, —C(R)—N(R)—, —O—C(R)—N(R)—, and —C(R)—N(OR)—; and'}, {'sub': '4', 'Ris alkyl.'}], 'Ris selected from the group consisting of hydrogen, ...
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