20-12-2018 дата публикации
Номер: US20180362972A1
Принадлежит:
The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer. 2. A method of treating cancer comprising the administration of a pharmaceutical composition according to to a subject having cancer.4. The pharmaceutical composition according to claim 1 , wherein the molecule of formula (I) claim 1 , (II) or (III) has one or several of the following features:n is an integer from 23 to 195 or from 27 to 95; and/orN is a deoxynucleotide selected from the group consisting of A (adenine), C (cytosine), T (thymine) and G (guanine) and selected so as to avoid occurrence of a CpG dinucleotide and to have less than 80% sequence identity to any gene in a human genome; and/orthe linked L′ is selected from the group consisting of hexaethyleneglycol, tetradeoxythymidylate (T4), 1,19-bis(phospho)-8-hydraza-2-hydroxy-4-oxa-9-oxo-nonadecane and 2,19-bis(phosphor)-8-hydraza-1-hydroxy-4-oxa-9-oxo-nonadecane; and/orm is 1 and L is a carboxamido polyethylene glycol, more preferably carboxamido triethylene glycol or carboxamido tetraethylene glycol; and/orC is selected from the group consisting of a cholesterol, single or double chain fatty acids such as octadecyl, oleic acid, dioleoyl or stearic acid, or ligand (including peptide, protein, aptamer) which targets cell receptor such as folic acid, tocopherol, sugar such as galactose and mannose and their oligosaccharide, peptide such as RGD and bombesin, and protein such transferring and integrin, preferably is a cholesterol or a tocopherol, still more preferably a cholesterol.9. The pharmaceutical composition according to claim 1 , wherein the PARP inhibitor is selected from the group consisting of rucaparib (AG014699 claim 1 , PF-01367338) claim 1 , olaparib (AZD2281) claim 1 , veliparib (ABT888) claim 1 , iniparib (BSI 201) claim 1 , niraparib (MK 4827) claim 1 , talazoparib (BMN673) claim 1 , AZD 2461 claim 1 , CEP 9722 claim 1 , E7016 claim 1 , INO-1001 claim 1 , LT-673 claim 1 , MP-124 ...
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