Printer

A printer comprises a printing mechanism arranged to print an image on an image receiving medium, wireless receiver means for receiving image data for printing on said image receiving medium. The wireless receiver means is arranged to receive signals having a frequency of the order of Gigahertz.

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Multi-compartment recloseable rigid domed package

Multi-compartment rigid tray with recloseable rigid dome lid

Disclosed are rigid multi-compartment recloseable packages. A package may comprise a rigid tray comprising a product surface to hold food products. The tray may comprise a raised lip along a perimeter of the product surface to laterally secure the food products thereon. The tray may have a tray skirt horizontally extending outward from a top edge of the lip, and dividing features upwardly extending from the product surface to form distinct compartments on the product surface for receiving the food products therein. Furthermore, such an exemplary package also comprises a recloseable rigid lid having an upper surface substantially coextensive with the product surface, and at least one sidewall downwardly extending from the upper surface. The lid may also comprise a lid skirt horizontally extending outward from a bottom edge of the at least one sidewall, where the lid skirt is coextensive and complimentary in shape with the tray skirt.

Finger vibrator

Control of Dual Printing Mechanisms

A printing system comprising: a printing device having first and second similar printing mechanisms; first and second similar holding means for holding respective first and second rolls of label stock in a position to pass the first and second printing mechanisms respectively; and a local processor connected to supply print data to a selected one of said first and second printing mechanisms and comprising means for receiving print data and a command for supplying said print data to the selected one of said first and second printing mechanisms to print an image on a label of the respective associated one of said first and second rolls of label stock, based on said command; and a host computer connected to the printing system and arranged to execute a common printer driver for supplying said print data and command to the printing device, regardless of which printing mechanism is selected.

Structure for accessing and populating community websites

A website structure for populating the registration database of a website, and for providing access to information contained within various community areas that comprise the website. A plurality of community areas are provided via website pages which contain information pertaining to a community interest. Each registered user will have a home page with personal information. Other overlying community areas might provide group information to which a user belongs, or organizational information to which a group belongs, and so forth. The information within the community areas can be viewed and shared by various users of the website, with access to the information controlled by the status of the user. The membership database for the website is built via invitations from member users to non-member users. An identification can be assigned to each relationship. Access to various information within the community areas is thereby controlled by the status of the user, or the relationship the user ...

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Martini tool

Stool

Automated Internet Based Interactive Travel Planning and Management System

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Rattle

Finger Vibrator

The present invention relates to vibrating devices for applying vibrations to body parts, particularly for female stimulation, and more particularly to the field of sexual stimulation of the clitoris. One embodiment is a device for applying vibration to a body part of a user, the device comprising: a vibrator mechanism; and, a body enclosing the vibrator mechanism, wherein the body comprises a first portion and a second portion; wherein the body and the vibrator mechanism are configured to allow the first portion to provide a first vibratory sensation to the user when the first portion is applied to the body part; and, wherein the body and the vibrator mechanism are configured to allow the second portion to provide a second vibratory sensation to the user when the second portion is applied to the body part. 1. A device for applying vibration to a body part of a user , the device comprising:a vibrator mechanism; and,a body enclosing the vibrator mechanism, wherein the body comprises a first portion and a second portion;wherein the body and the vibrator mechanism are configured to allow the first portion to provide a first vibratory sensation to the user when the first portion is applied to the body part; and, wherein the body and the vibrator mechanism are configured to allow the second portion to provide a second vibratory sensation to the user when the second portion is applied to the body part.2. The device of claim 1 , wherein the body further comprises a neck;wherein the device is configured to allow fingers of the user to engage the neck to maintain the body in a first orientation relative to the fingers of the user to allow the user to apply the first portion to the body part; and, wherein the device is configured to allow fingers of the user to engage the neck to maintain the device in a second orientation relative to the fingers of the user to allow the user to apply the second portion to the body part.3. The device of claim 2 , further comprising:a ...

Truck shell

A molded truck shell is provided having side walls hinged along the top of the shell, thus allowing the entire side wall to pivot upwardly and outwardly, providing increased access to cargo stored in a truck bed. Additional lateral seams between the side wall and shell are located on the front and rear of the shell rather than on the side of the shell thereby further increasing the opening into the truck bed and creating a visually clean appearance. Water penetrating through the side wall hinge line is directed away from the interior of the truck bed by a moisture flange that conducts the water to the exterior of the truck.

Label printer

A label printer includes a receiving area configured for receiving a cartridge that includes a roll of media for printing labels thereon, the receiving area also including features for aligning a plurality of differently sized cartridges with a printing mechanism; and components configured for adjusting label sizing to provide virtual label sizes.

Vibrating electromechanical device

Case for a vibrating electromechanical device for female stimulation

CARTRIDGE FOR LABEL PRINTER

In one embodiment, a cartridge body for a cartridge for providing media to a printer includes a first part and a complimentary second part, the first part and the second part formed of post-consumer-material; a hinge integrally connected to the first part and the second part and adapted to close the first part and the second part together over the media and contain the media therein; and an opening formed by the closed first part and second part for dispensing the media to the printer. A cartridge is also disclosed.

PRINTER

A label printer comprising: a connector configured to allow said label printer to be connected to a PC; at least one memory; at least one processor; said label printer being configured to function as a Human Interface Device (HID) when connected to said PC. 1. A label printer comprising:a connector configured to allow said label printer to be connected to a PC;at least one memory;at least one processor;said label printer being configured to function as a Human Interface Device (HID) when connected to said PC;wherein said label printer is configured for bi-directional communication with said PC on a HID channel; andwherein said label printer is configured to send information relating to a supply of image receiving tape mounted in said label printer on said HID channel.2. A label printer as set forth in wherein said label printer is configured to function as a Human Interface Device upon connection of said label printer to said PC.3. A label printer as set forth in claim 1 , wherein said label printer is further configured to function as a mass storage device (MSD) drive when connected to said PC.4. A label printer as set forth in wherein said MSD drive is comprised in said at least one memory.5. A label printer as set forth in wherein said at least one memory comprises Flash memory.6. A label printer as set forth in claim 1 , wherein said information on said HID channel comprises print data.7. A label printer as set forth in claim 6 , wherein said print data received via said HID channel is created using a first text-editor program.8. A label printer as set forth in claim 7 , wherein said label printer is configured to print said print data received via said HID channel.9. A label printer as set forth in wherein said information comprises a firmware update.10. A label printer as set forth in claim 1 , wherein said label printer is configured to send label printer information to said PC on said HID channel.11. A label printer as set forth in claim 10 , wherein said ...

Brake mechanism for a device for drying foods and other items

A brake assembly for reducing the rotational velocity the spinning basket of a food spinning device applies a frictional force to an annular ridge on the lid of the spinning basket. A brake button movably disposed in a cover of the spinning device includes flexible pinching arms having cam surfaces. The cam surfaces of the flexible pinching arms extend through a guide aperture, thereby causing the pinching arms to flex toward each other when the brake button is depressed and to apply the frictional engagement to the annular ridge.

Cartridge for label printer

In one embodiment, a cartridge body for a cartridge for providing media to a printer includes a first part and a complimentary second part, the first part and the second part formed of post-consumer-material; a hinge integrally connected to the first part and the second part and adapted to close the first part and the second part together over the media and contain the media therein; and an opening formed by the closed first part and second part for dispensing the media to the printer. A cartridge is also disclosed.

Multi-compartment recloseable rigid domed package

Control of dual printing mechanisms

A printing system comprising: a printing device having first and second similar printing mechanisms; first and second similar holding means for holding respective first and second rolls of label stock in a position to pass the first and second printing mechanisms respectively; and a local processor connected to supply print data to a selected one of said first and second printing mechanisms and comprising means for receiving print data and a command for supplying said print data to the selected one of said first and second printing mechanisms to print an image on a label of the respective associated one of said first and second rolls of label stock, based on said command; and a host computer connected to the printing system and arranged to execute a common printer driver for supplying said print data and command to the printing device, regardless of which printing mechanism is selected.

Stereo speaker stand

Vibrating electromechanical device for female stimulation

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Salad spinner

Hybrid printer

A printing device comprising a casing having a first part housing a first printing mechanism which comprises a printhead and a platen located at a print zone, and a holder for holding a roll of precut label stock in a position to pass through the print zone, and a second part housing a second printing mechanism which comprises a printhead and a platen located at a print zone and means for receiving a cassette housing image receiving tape in a position to pass through the print zone.

Tape printers

The present invention relates to a tape printing system for printing an image on an image receiving tape comprising means for receiving a supply of image receiving tape; means for generating a plurality of labels from a data source, said generating means comprising means for receiving said data, means for processing said data to identify individual label data to be printed on said plurality of labels and means for generating label date from the identified individual label data; and means for printing said plurality of labels.

METHODS OF USING IMMUNOGLOBULIN AGGREGATES

The current invention provides a method of treating a mammal in need of such treatment with aggregated IgG derived from pooled human plasma. The invention further provides using the discarded fraction obtained during the course of standard IgG fractionation as the source of the aggregated IgG. The methods of the invention further provide for enhancing the aggregation of the aggregate fraction as well as enriching and modifying glycoforms.

FUSION PROTEINS COMPRISING IGG2 HINGE DOMAINS

The present invention relates to biologically active fusion proteins containing the IgG2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins. 1. A fusion protein comprising:one or more IgG2 hinge monomers; andone or more peptides, proteins, carbohydrates/sugars or small moleculeswherein said one or more IgG2 hinge domains multimerizes said one or more peptides, proteins or small molecules into dimers or higher order multimers.2. The fusion protein of claim 1 , wherein said one or more peptides claim 1 , proteins or small molecules is any peptide claim 1 , protein claim 1 , small molecule or carbohydrate/sugar whose activity is improved by multimerization.3. The fusion protein of claim 2 , wherein said protein or peptide is selected from the group consisting of cytokines claim 2 , chemokines claim 2 , hormones claim 2 , monoclonal antibodies and antibody-like compounds claim 2 , cell surface receptors claim 2 , cell surface receptor ligands and fragments thereof.4. The fusion protein of wherein the protein is selected from the group consisting of PD-1 claim 2 , PDL-1L claim 2 , CERVIG peptide claim 2 , CTLA4 claim 2 , IL12 claim 2 , IL12RA claim 2 , major histocompatibility complex and insulin.5. The fusion protein of claim 2 , wherein said peptide is selected from the group consisting of the external domain of PD-1 claim 2 , CTLA4 claim 2 , the p40 subunit of IL12 claim 2 , and human parathyroid hormone6. The fusion protein of claim 2 , wherein said small molecule is selected from the group consisting of chemotherapeutic agents claim 2 , cytotoxic molecules claim 2 , dyes and flurophores.7. The fusion protein of claim 2 , wherein the carbohydrate/sugar is selected from the group consisting of monosaccharides claim 2 , disaccharides claim 2 , oligosaccharides claim 2 , ...

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Travel watch

Automated internet based interactive travel planning and reservation system

An interactive rapid response Internet accessed air travel planning and reservation system responds either via voice communication or data communication, to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member.

LABEL PRINTER

A label printer includes a receiving area configured for receiving a cartridge that includes a roll of media for printing labels thereon, the receiving area also including features for aligning a plurality of differently sized cartridges with a printing mechanism; and components configured for adjusting label sizing to provide virtual label sizes.

Vibrating electromechanical device

Margarita tool

Multi-Compartment Rigid Tray with Recloseable Rigid Dome Lid

Disclosed are rigid multi-compartment recloseable packages. A package may comprise a rigid tray comprising a product surface to hold food products. The tray may comprise a raised lip along a perimeter of the product surface to laterally secure the food products thereon. The tray may have a tray skirt horizontally extending outward from a top edge of the lip, and dividing features upwardly extending from the product surface to form distinct compartments on the product surface for receiving the food products therein. Furthermore, such an exemplary package also comprises a recloseable rigid lid having an upper surface substantially coextensive with the product surface, and at least one sidewall downwardly extending from the upper surface. The lid may also comprise a lid skirt horizontally extending outward from a bottom edge of the at least one sidewall, where the lid skirt is coextensive and complimentary in shape with the tray skirt.

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

Molecules with antigen binding and polyvalent FC gamma receptor binding activity

The current invention involves biologically active proteins termed stradobodies. The stradobodies have two or more domains that create stradobody multimers. The stradobodies have both antigen-binding capacity and the ability to bind Fc receptors (FcR), and are useful in the treatment and prevention of disease.

Secure Mobile Device

The present invention is a communication device with secure data storage having a secure platform with no network connection and a main mobile platform with at least one network connection. 1) A communication device with secure data storage , comprising:a secure platform having a processor, a data storage unit, and no network connection;a main mobile platform having a processor, a data storage unit, and at least one wireless network connection;a user interface;a power storage unit;a plurality of biometric sensors that receive biometric information to verify a user's identity;a switch control that provides selective connectivity between either the user interface and the secure platform or the user interface and the main platform, but not both simultaneously, wherein the switch control provides connectivity between the secure platform and the user interface only once the plurality of biometric sensors receive the biometric information to verify the user's identity.2) The device of further comprising:at least two biometric sensors, wherein each biometric sensors receives distinct biometric information.3) The device of wherein biometric information is a fingerprint claim 1 , handprint claim 1 , facial scan claim 1 , cranial scan claim 1 , iris scan claim 1 , retina scan claim 1 , voice sample claim 1 , or DNA information.4) The device of further comprising:a detachable ringing component that communicates with the main platform wirelessly, wherein the ringing component and the main mobile platform each emit a signal when separated by greater than a preset limited distance.5) The device of further comprising:a sealed housing, wherein the sealed housing prevents water from entering the device.6) The device of further comprising:a retractable cord for charging the device.7) The device of further comprising:a photovoltaic film that produces electricity from incident electromagnetic radiation.8) The device of further comprising:an induction unit that produces electricity from ...

Container insert

CONTROLLER

A controller arranged to provide print data to a print apparatus, said print data comprising an image to be printed on a disc, said image being such that at least one print parameter is determinable from said image when printed on said disc; receive said at least one print parameter; and control a subsequent printing operation on a disc based on said received at least one print parameter.

Travel watch with a round face

Finger vibrator

The present invention relates to vibrating devices for applying vibrations to body parts, particularly for female stimulation, and more particularly to the field of sexual stimulation of the clitoris. One embodiment is a device for applying vibration to a body part of a user, the device comprising: a vibrator mechanism; and, a body enclosing the vibrator mechanism, wherein the body comprises a first portion and a second portion; wherein the body and the vibrator mechanism are configured to allow the first portion to provide a first vibratory sensation to the user when the first portion is applied to the body part; and, wherein the body and the vibrator mechanism are configured to allow the second portion to provide a second vibratory sensation to the user when the second portion is applied to the body part.

HYBRID PRINTER

A printing device comprising a casing having a first part housing a first printing mechanism which comprises a printhead and a platen located at a print zone, and a holder for holding a roll of precut label stock in a position to pass through the print zone, and a second part housing a second printing mechanism which comprises a printhead and a platen located at a print zone and means for receiving a cassette housing image receiving tape in a position to pass through the print zone.

Label-making techniques and systems

In a method for adapting a label-making tool, a selection component may be presented via a user interface. The selection component may include a finite set of items corresponding to types of objects for labels. User input selecting an item corresponding to a type of label object may be received. Data-acquisition actions performable by the label-making tool to obtain data for the label object may be identified based on the type of the label object. A selection component including a finite set of items corresponding to the data-acquisition actions may be presented. User input selecting an item corresponding to a data-acquisition action may be received. The workflow of a label-making tool may be adapted to include the data-acquisition action. The tool may be configured to perform the data-acquisition action to generate a label including the obtained data.

Secure mobile device

The present invention is a communication device with secure data storage having a secure platform with no network connection and a main mobile platform with at least one network connection.

Mojito tool

Business analysis tool

In accordance with an exemplary embodiment of the invention, a single automated accounting and business analysis system is employed to acquire, organize, record, analyze and plan all the relevant financial and non-financial business metrics required by a company's management, suppliers, creditors, shareholders, regulators, etc. This includes all the internally generated metrics and external metrics such as data related to the economy, a particular industry, weather conditions, etc.

Electronic concession stand

Described are techniques used in an on-line concession stand using software. The on-line concession stand (MCS) application includes an order wizard, a supplier console and a database of information. The MCS application provides for users to view and purchase products on-line from suppliers. Any one or more a variety of communication techniques and devices may be used in completing the transaction including instant messaging. A database organization includes a data organization to facilitate the transaction as well as electronic browsing.

Truck shell

A molded truck shell having side walls hinged along the top of the shell, allowing the entire side wall to pivot upwardly and outwardly, providing increased access to cargo stored in a truck bed. Additional lateral seams between the side wall and shell are located on the front and rear of the shell rather than on the side of the shell thereby further increasing the opening into the truck bed and creating a visually clean appearance. Water penetrating through the side wall hinge line is directed away from the interior of the truck bed by a moisture flange that conducts the water to the exterior of the truck.

Benomyl tolerant fusarium lateritium and uses thereof

The invention provides methods for treating a plant having an exposed wound to increase resistance against a plant pathogen, by applying an effective amount of a benomyl solution, in conjunction with inoculating the pruning wound with a fungal organism resistant to the benomyl concentration. The invention also provides a benomyl tolerant F. lateritium which is particularly adapted for the treatment of grapevine pruning wounds to control Eutypa dieback.

METHOD AND APPARATUS FOR TESTING AN INTEGRATED CIRCUIT INCLUDING AN I/O INTERFACE

Methods and apparatus provide for testing an integrated circuit including an input/output (I/O) interface. The method and apparatus place the I/O interface in a test mode by test enabling logic. During the test mode, the method and apparatus also provide, by a clock generator in the I/O interface, an internal phase-aligned receiver clock signal to a plurality of transceivers in the I/O interface. The clock generator is a transmitter portion of one of the plurality of transceivers in the I/O interface. The method and apparatus then monitor for errors in loopback data from the plurality of transceivers in the I/O interface by an automatic test equipment (ATE). The phase of the internal phase-aligned receiver clock signal is aligned with the loopback data of the plurality of transceivers, and the frequency of the internal phase-aligned receiver clock signal may be above about 200 MHz. 1. A method for testing an integrated circuit , the method comprising:placing an input/output (I/O) interface in a test mode;during the test mode, providing, by a clock generator in the I/O interface, an internal phase-aligned receiver clock signal to a plurality of transceivers in the I/O interface, wherein the clock generator is a transmitter portion of one of the plurality of transceivers in the I/O interface; andmonitoring for errors in loopback data from the plurality of transceivers in the I/O interface.2. The method of claim 1 , wherein providing the internal phase-aligned receiver clock signal comprises:generating, by the clock generator, the internal phase-aligned receiver clock signal; anddistributing the internal phase-aligned receiver clock signal uniformly to each one of the plurality of transceivers in the I/O interface through a balanced clock tree.3. The method of claim 1 , wherein providing the internal phase-aligned receiver clock signal comprises providing a transmitter clock signal to the plurality of transceivers in the I/O interface.4. The method of claim 3 , wherein ...

Control of dual printing mechanisms

A printing system comprising: a printing device having first and second similar printing mechanisms; first and second similar holding means for holding respective first and second rolls of label stock in a position to pass the first and second printing mechanisms respectively; and a local processor connected to supply print data to a selected one of said first and second printing mechanisms and comprising means for receiving print data and a command for supplying said print data to the selected one of said first and second printing mechanisms to print an image on a label of the respective associated one of said first and second rolls of label stock, based on said command; and a host computer connected to the printing system and arranged to execute a common printer driver for supplying said print data and command to the printing device, regardless of which printing mechanism is selected.

Brake Mechanism for a Device for Drying Foods and Other Items

A brake assembly for reducing the rotational velocity the spinning basket of a food spinning device applies a frictional force to an annular ridge on the lid of the spinning basket. A brake button movably disposed in a cover of the spinning device includes flexible pinching arms having cam surfaces. The cam surfaces of the flexible pinching arms extend through a guide aperture, thereby causing the pinching arms to flex toward each other when the brake button is depressed and to apply the frictional engagement to the annular ridge. 1. A device for drying food comprising:a container including a bowl having a sidewall terminating at an edge defining an opening and a cover removably coupled to the bowl and substantially covering the opening;a basket assembly disposed in the bowl and rotatable relative to the container about an axis of rotation, the basket assembly including a basket having a sidewall with perforations and terminating at a top edge and a lid releasably coupled to the top edge of the basket;an upstanding generally annular ridge extending from a top surface of the lid toward the cover, the ridge disposed substantially coaxially about the axis of rotation; anda brake assembly including a brake button carried by the cover, wherein the brake button is operably coupled to pinching arms extending substantially parallel to the axis of rotation and movable between a non-braking position and a braking position wherein the pinching arms frictionally engage the annular ridge upon translation of the brake button relative to the lid, wherein the pinching arms flex toward each other when moving toward the braking position.2. The device of claim 1 , wherein axial translation of the brake button toward the lid causes the pinching arms to be disposed in the braking position claim 1 , wherein the pinching arms frictionally engage the circular annular ridge upon translation of the brake button relative to the lid.3. The device of claim 2 , wherein the pinching arms are ...

Cell phone housing

Hand held vibrating electromechanical stimulation device

Business analysis tool

In accordance with an exemplary embodiment of the invention, a single automated accounting and business analysis system is employed to acquire, organize, record, analyze and plan all the relevant financial and non-financial business metrics required by a company's management, suppliers, creditors, shareholders, regulators, etc. This includes all the internally generated metrics and external metrics such as data related to the economy, a particular industry, weather conditions, etc.

Tape printers

The present invention relates to a tape printing system for printing an image on an image receiving tape comprising means for receiving a supply of image receiving tape; means for generating a plurality of labels from a data source, said generating means comprising means for receiving said data, means for processing said data to identify individual label data to be printed on said plurality of labels and means for generating label date from the identified individual label data; and means for printing said plurality of labels.

Terminal with integral printers

Multi-compartment recloseable rigid domed package

Hybrid printer

A printing device comprising a casing having a first part housing a first printing mechanism which comprises a printhead and a platen located at a print zone, and a holder for holding a roll of precut label stock in a position to pass through the print zone, and a second part housing a second printing mechanism which comprises a printhead and a platen located at a print zone and means for receiving a cassette housing image receiving tape in a position to pass through the print zone.

FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for Fc Rs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity. 1156-. (canceled)157. A stradomer unit comprising:(a) a leader sequence(b) an IgG1 Fc domain; and(c) a multimerization domain;wherein the leader sequence is directly linked to the IgG1 Fc domain and wherein the IgG1 Fc domain is directly linked to the multimerization domain or wherein the leader sequence is directly linked to the multimerization domain and the multimerization domain is directly linked to the IgG1 Fc domain.158. The stradomer unit of wherein the IgG1 Fc domain is about 90% homologous to SEQ ID NO:2.159. The stradomer unit of wherein the IgG1 Fc domain comprises the CH2 and CH3 domains of IgG1.160. Stradomer unit of wherein the IgG1 Fc domain is at least about 90% homologous to SEQ ID NO: 19.161. The stradomer unit of wherein the multimerization domain is an IgG2 hinge.162. The stradomer unit of wherein the amino acid sequence of the multimerization domain is about 90% homologous to SEQ ID NO: 3 and is capable of multimerizing said stradomer units.163. The stradomer unit of wherein the multimerization domain is directly linked to the amino terminus of the IgG1 Fc domain or the carboxy terminus of the IgG1 Fc domain.164. The stradomer unit of wherein the stradomer unit comprises: SEQ ID NO: 4 claim 157 , SEQ ID NO: 8 or SEQ ID NO: 18.165. The stradomer unit of wherein the multimerization domain creates multimers of said ...

Decision feedback equalization with selectable tap

A system generates a set of candidate signals based on a received signal, whereby each candidate signal represents an adjustment of the signal for a different amount of potential noise. The system selects one of the candidate signals based on a selected subset of previous samples and the values of the selected subset of samples. The subset of previous samples is selected based on a predicted noise pattern.

MOLECULES WITH ANTIGEN BINDING AND POLYVALENT FC GAMMA RECEPTOR BINDING ACTIVITY

The current invention involves biologically active proteins termed stradobodies. The stradobodies have two or more domains that create stradobody multimers. The stradobodies have both antigen-binding capacity and the ability to bind Fc receptors (FcR), and are useful in the treatment and prevention of disease. 1. A stradobody comprising an Fab domain; one or more Fc domains; and one or more multimerization domains , wherein the one or more multimerization domains separates two Fc domains or is located at the carboxy terminus of the one or more Fc domains , and wherein the one or more multimerization domains is capable of multimerizing said stradobody.23.-. (canceled)4. The stradobody of claim 1 , wherein the one or more multimerization domains are independently selected from the group consisting of an isoleucine zipper claim 1 , an IgG2 hinge claim 1 , and a GPP repeat.5. The stradobody of claim 1 , wherein the stradobody comprises at least one IgG2 hinge domain claim 1 , wherein the amino acid sequence of the IgG2 hinge domain is at least 80% homologous to SEQ ID NO: 3 claim 1 , and wherein the IgG2 hinge is capable of multimerizing the stradobody.6. The stradobody of claim 1 , wherein the stradobody comprises at least one isoleucine zipper claim 1 , wherein the amino acid sequence of the at least one isoleucine zipper is at least 80% homologous to SEQ ID NO: 32 claim 1 , and wherein the isoleucine zipper is capable of multimerizing the stradobody.7. The stradobody of claim 1 , wherein the stradobody comprises two multimerization domains.8. The stradobody of claim 7 , wherein the two multimerization domains are an isoleucine zipper and an IgG2 hinge.9. The stradobody of claim 8 , wherein the two multimerization domains separate two Fc domains.10. The stradobody of claim 8 , wherein the two multimerization domains are located at the carboxy end of the Fc region.1112.-. (canceled)13. The stradobody of claim 1 , wherein the at least one Fc domain is an IgG1 Fc domain ...

FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcγRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity. 1156-. (canceled)157. A multimerized compound comprising two or more homodimeric stradomer units , wherein each homodimeric stradomer unit comprises an IgG1 Fc domain monomer directly linked at its carboxy terminus to an IgG2 hinge domain monomer wherein said IgG2 domain multimerizes the homodimeric stradomer units such that the multimerized compound is capable of binding to two or more Fc gamma receptors (FcγRs).158. The compound of claim 157 , wherein the IgG1 Fc domain comprises a CH2 and a CH3 domain of IgG1.159. The compound of claim 158 , wherein the IgG1 Fc domain further comprises an IgG1 hinge.160. The compound of claim 157 , wherein the IgG1 Fc domain comprises an amino acid sequence that is about 90% homologous to SEQ ID NO: 2.161. The compound of claim 157 , wherein the amino acid sequence of the IgG2 hinge is about 90% homologous to SEQ ID NO: 3.162. The compound of claim 157 , wherein the two or more stradomer units each comprise amino acids 21-264 of SEQ ID NO: 4.163. The multimerized compound of claim 157 , comprising 2 claim 157 , 3 claim 157 , 4 claim 157 , 5 claim 157 , or 6 stradomer units.164. A multimerized compound comprising two or more homodimeric stradomer units claim 157 , wherein each homodimeric stradomer unit consists of an IgG1 Fc domain monomer directly linked at its carboxy terminus to an IgG2 hinge ...

FUSION PROTEINS COMPRISING IGG2 HINGE DOMAINS

The present invention relates to biologically active fusion proteins containing the IgG2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins. 1151-. (canceled)152. A fusion protein comprising an IgG2 hinge domain monomer and an immunoglobulin Fc domain monomer , wherein the immunoglobulin Fc domain monomer is selected for poor binding to Fc gamma receptors.153. The fusion protein of claim 152 , wherein the IgG2 hinge domain monomer is at least 95% homologous to SEQ ID NO: 1.154. The fusion protein of claim 152 , wherein the IgG2 hinge domain monomer is 100% homologous to SEQ ID NO: 1.155. The fusion protein of claim 152 , wherein the IgG2 hinge domain monomer comprises at least two C-X-X-C motifs.156. The fusion protein of claim 155 , wherein the XX in the C-X-X-C motif comprises V-E or P-P.157. The fusion protein of claim 152 , wherein the immunoglobulin Fc domain monomer is an IgG1 claim 152 , IgG2 claim 152 , IgG3 or IgG4 Fc domain monomer selected for poor binding to Fc gamma receptors.158. The fusion protein of claim 152 , wherein the immunoglobulin Fc domain monomer is an IgE Fc domain monomer.159. The fusion protein of or wherein said immunoglobulin Fc domain monomer is mutated to bind poorly to Fc gamma receptors.160. The fusion protein of claim 159 , wherein said Fc domain is mutated at one or more of positions 233 claim 159 , 234 claim 159 , 235 claim 159 , 236 claim 159 , 238 claim 159 , 239 claim 159 , 265 claim 159 , 269 claim 159 , 270 claim 159 , 292 claim 159 , 293 claim 159 , 295 claim 159 , 296 claim 159 , 297 claim 159 , 303 claim 159 , 327 claim 159 , 329 claim 159 , 338 claim 159 , 376 claim 159 , and/or 414.161. The fusion protein of or wherein said immunoglobulin Fc domain monomer is modified to bind poorly to Fc gamma receptors.162. The fusion ...

TIMER

Timers having various functionalities, form factors, and control systems are described. Timers may include single button controls, no-button controls, controls having buttons corresponding to each of several selectable durations. The timers may include task lights, pin lights, and/or lantern type lights. The timers may be powered by removable or permanent batteries, which may be rechargeable by way of, for example, a USB cord, or may be powered by AC or DC adaptor plugs. 1. A timer comprising:a plurality of buttons, each button corresponding to a selected time increment;a processor, configured to, in response to a plurality of presses of one or more of the plurality of buttons, set a duration for operation of the timer; andan indicator, configured and arranged to, at an end of the set duration, provide an indication of expiration of the set duration.2. A timer as in claim 1 , further comprising a display configured and arranged to display an amount of time remaining of the set duration.3. A timer as in claim 1 , sized and configured to fit in a user's hand.4. A timer as in claim 3 , wherein a length of the timer is between 3 and 6 inches and a diameter of the timer is between 1 and 3 inches.5. A timer as in claim 1 , wherein the display is below a translucent portion of a top surface of the timer and light from the display is visible through the translucent portion.6. A timer as in claim 1 , wherein after the set duration is selected claim 1 , the timer automatically begins to count down after a time interval.7. A timer as in claim 1 , further comprising a light claim 1 , the light operable by lifting the timer from a surface on which the timer is placed.8. A timer as in claim 7 , wherein the lifting is determined by a light detector positioned on a base of the timer.9. A timer as in claim 7 , wherein the lifting is determined by an accelerometer.10. A timer comprising:a plurality of sides, each side having an indicium of a duration amount;a sensor configured and ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases. 1170-. (canceled)171. A method of treating an inflammatory disease comprising administering an immunologically active biomimetic comprising:at least two Fc domains, each Fc domain capable of binding to an FcR and each Fc domain comprising an IgG CH2 domain and an LPG CH3 domain and wherein each Fc domain optionally comprises at least one IgG.172. The method of wherein the IgG CH2 domain is an IgG1 CH2 domain claim 171 , an IgG3 CH2 domain or an IgG4 CH2 domain.173. The method of wherein the IgG CH3 domain is an IgG1 CH3 domain claim 171 , an IgG3 CH3 domain or an IgG4 CH3 domain.174. The method of wherein the IgG CH2 and IgCH3 domain are IgG1 CH2 and CH3 domains.175. The method of wherein the IgG CH2 and IgG CH3 domain are IgG3 CH2 and CH3 domains.176. The method of wherein the IgG CH2 and IgCH4 domain are IgG1 CH2 and CH3 domains.177. The method of wherein the at least one IgG hinge is an IgG2 hinge.178. The method of further comprising an IgG1 hinge.179. A method of treating an inflammatory disease comprising administering an immunologically active biomimetic comprising:at least two Fc domains, each Fc domain capable of binding to an FcR and each Fc domain comprising an IgG hinge domain and an IgG CH2 domain and wherein each Fc domain optionally comprises an IgG CH3 domain.180. The method of wherein the IgG hinge domain comprises an IgG1 claim 179 , IgG2 claim 179 , IgG3 or IgG4 hinge.181. The method of wherein the IgG CH2 is comprises an IgG1 claim 179 , IgG3 or IgG4 ...

FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcγRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity. 1156.-. (canceled)157. A method of treating an inflammatory disease or autoimmune disease in a subject in need thereof comprising administering to the subject an effective amount of a pharmaceutical composition comprising a multimerized compound comprising two or more homodimeric stradomer units ,wherein each homodimeric stradomer unit comprises two stradomer unit monomers, andwherein each stradomer unit monomer comprises amino acid residues 21-264 of SEQ ID NO:4.158. The method of claim 157 , wherein the multimerized compound comprises 2 claim 157 , 3 claim 157 , 4 claim 157 , 5 claim 157 , 6 claim 157 , 7 claim 157 , or more homodimeric stradomer units.159. The method of claim 157 , wherein the pharmaceutical composition comprises higher order multimers.160. The method of claim 157 , wherein the autoimmune or inflammatory disease is capable of being treated with human IVIG.161pemphigus. The method of claim 157 , wherein the inflammatory or autoimmune disease is selected from multifocal motor neuropathy (MMN) claim 157 , Alzheimer's disease claim 157 , sepsis claim 157 , arthritis claim 157 , multiple sclerosis claim 157 , autoimmune thyroiditis claim 157 , chronic inflammatory polyneuropathy claim 157 , scleroderma claim 157 , autoimmune uveitis claim 157 , systemic lupus erythematosus (SLE) claim 157 , myasthenia gravis claim 157 , ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases. 1170-. (canceled)171. A cluster stradomer comprising two or more multimerized cluster stradomer units , wherein each of said cluster stradomer units comprises from amino terminus to carboxy terminus ,(a) at least one multimerization region which multimerizes the cluster stradomer units to form the cluster stradomer wherein the multimerizing region is an IgG2 hinge or isoleucine zipper; and(b) at least one Fc domain comprising a CH2 and CH3 domain from IgG1, IgG3 or IgG4 wherein the cluster stradomer is capable of specifically binding to at least two Fc receptors.172. The cluster stradomer of wherein said cluster stradomer does not contain an antigen-binding Fab domain.173. The cluster stradomer of wherein the Fc domain further comprises an IgG hinge domain from IgG 1 claim 171 , IgG3 or IgG4.174. The cluster stradomer of wherein the multimerizing region is an IgG2 hinge.175. The cluster stradomer of wherein the multimerizing region is an isoleucine zipper.176. The cluster stradomer of claim 171 , comprising two multimerized cluster stradomer units.177. The cluster stradomer of claim 171 , comprising three multimerized cluster stradomer units.178. The cluster stradomer of claim 171 , comprising four multimerized cluster stradomer units.179. The cluster stradomer of claim 171 , comprising five or more multimerized cluster stradomer units.180. The cluster stradomer of wherein at least one of the cluster stradomer units comprises two or more Fc domains.181. The cluster ...

INDUCED GAS FLOTATION FOR SEPARATION FACILITY

A method can include providing at a location remote from a tank of a pre-existing separation facility an induced gas separation unit including a pump and an eductor, then transporting the induced gas separation unit to the separation facility, then connecting the induced gas separation unit to the tank, and then operating the induced gas separation unit, thereby pumping gas into a fluid composition in the tank. A system can include an induced gas separation unit with a pump and an eductor mounted to a portable structure, a line providing fluid communication between a pump inlet and the fluid composition in at least one tank, a line providing fluid communication between the eductor and a gas in the tank, and a third line providing fluid communication between an eductor outlet and the fluid composition in the tank. 1. A method of providing for induced gas separation at a pre-existing separation facility , the method comprising:at a location remote from at least one tank of the separation facility, providing an induced gas separation unit comprising a pump and an eductor;then transporting the induced gas separation unit to the separation facility;then connecting the induced gas separation unit to the at least one tank; andthen operating the induced gas separation unit, thereby pumping gas into a fluid composition in the at least one tank.2. The method of claim 1 , in which the connecting step comprises providing fluid communication between the eductor and an upper gas-filled portion of the at least one tank.3. The method of claim 1 , in which the connecting step comprises providing fluid communication between the at least one tank and an inlet of the pump.4. The method of claim 3 , in which the connecting step comprises providing fluid communication between the at least one tank and an outlet of the pump.5. The method of claim 1 ,in which the at least one tank comprises at least one retention tank, andin which the connecting step comprises providing fluid communication ...

METHODS OF TREATING INFLAMMATORY DISORDERS WITH MULTIVALENT FC COMPOUNDS

The present invention provides methods for the identification of patients with an inflammatory or autoimmune disease that demonstrate an inadequate response to treatment with a multi-Fc therapeutic, and the determination of an optimal dose of a multi-Fc therapeutic for said patient based on the patient's circulating levels of inactivated C3b (iC3b) and/or additional complement components that may be employed as a surrogate for iC3b based on an analogous response to multi-Fc therapeutics. The present invention further provides for improvements in the use of such multi-Fc therapeutics in the treatment of autoimmune and inflammatory diseases 1. A method of treating an inflammatory or autoimmune disease in a patient determined to have an inadequate response to a multi-Fc therapeutic comprising administering a first cumulative escalated dose of the multi-Fc therapeutic at a dose of at least about 105% of a starting dose of said multi-Fc therapeutic during a first dosing period , wherein the patient has been determined to have:(a) blood levels of iC3b lower than a predetermined threshold following administration with the starting dose of the multi-Fc therapeutic; or(b) blood levels of iC3b with a change percent of less than about 10% from baseline.2. The method of claim 1 , further comprising determining the blood iC3b level of the patient after administration of the first cumulative escalated dose of the multi-Fc therapeutic and administering a second cumulative escalated dose of the multi-Fc therapeutic for a second dosing period that is higher than the first cumulative escalated dose if the patient is determined to have:(a) blood levels of iC3b lower than a predetermined threshold following administration with the starting dose of the multi-Fc therapeutic; or(b) blood levels of iC3b with a change percent of less than about 10% from baseline.3. The method of claim 2 , wherein the determination of blood iC3b levels is repeated with continued cumulative escalated doses of ...

MOLECULES WITH ANTIGEN BINDING AND POLYVALENT FC GAMMA RECEPTOR BINDING ACTIVITY

The current invention involves biologically active proteins termed stradobodies. The stradobodies have two or more domains that create stradobody multimers. The stradobodies have both antigen-binding capacity and the ability to bind Fc receptors (FcR), and are useful in the treatment and prevention of disease. 1128.-. (canceled)129. A method of modulating an immune response in a subject comprising administering to the subject an effective amount of a stradobody comprising an Fab domain; one or more Fc domains; and one or more multimerization domains , wherein the one or more multimerization domains separates two Fc domains or is located at the carboxy terminus of the one or more Fc domains , and wherein the one or more multimerization domains is capable of multimerizing said stradobody.130. The method of claim 129 , wherein the one or more multimerization domains are independently selected from the group consisting of an isoleucine zipper claim 129 , an IgG2 hinge claim 129 , and a GPP repeat.131. The method of claim 129 , wherein the stradobody comprises at least one IgG2 hinge domain claim 129 , wherein the amino acid sequence of the IgG2 hinge domain is at least 80% homologous to SEQ ID NO: 3 claim 129 , and wherein the IgG2 hinge is capable of multimerizing the stradobody.132. The method of claim 129 , wherein the stradobody comprises at least one isoleucine zipper claim 129 , wherein the amino acid sequence of the at least one isoleucine zipper is at least 80% homologous to SEQ ID NO: 32 claim 129 , and wherein the isoleucine zipper is capable of multimerizing the stradobody.133. The method of claim 129 , wherein the stradobody comprises two multimerization domains.134. The method of claim 133 , wherein the two multimerization domains are an isoleucine zipper and an IgG2 hinge.135. The method of claim 134 , wherein the two multimerization domains separate two Fc domains.136. The method of claim 134 , wherein the two multimerization domains are located at the ...

FOOD EXPIRATION REPORTING AND INTELLIGENCE TRACKING

Methods and apparatus for food expiration reporting and intelligent inventory tracking is provided. A food item inventory database is created listing at least food item name, quantity, and expiration date. It is then determined, via a computer processor associated with the food item inventory database, whether any of the food items have an expiration date falling within at least one future predetermined time period in order to identify expiring food items. An alert can then be generated at a user interface indicating that one or more of the food items have an expiration date falling within the at least one future predetermined time period. Based on this information, menu items can be adjusted, menu specials can be implemented, and intelligent inventory management can be facilitated. 1. A computerized method for food expiration reporting and intelligent inventory tracking , comprising:creating a food item inventory database comprising a listing of at least food item name, quantity, and expiration date;determining, via a computer processor associated with the food item inventory database, whether any of the food items have an expiration date falling within at least one future predetermined time period to identify expiring food items; andgenerating an alert at a user interface indicating that one or more of the food items have an expiration date falling within the at least one future predetermined time period.2. A computerized method in accordance with claim 1 , further comprising:enabling, via the user interface, display or printing of a report listing the identified expiring food items.3. A computerized method in accordance with claim 1 , wherein the at least one future predetermined time period comprises multiple future predetermined time periods.4. A computerized method in accordance with claim 3 , wherein the multiple future predetermined time periods comprise at least one of different predetermined time periods and overlapping time periods.5. A computerized ...

UNBALANCED MAPPING BETWEEN DESKTOP AND MOBILE PAGES

A collaboration service is disclosed that hosts various collaboration sites. Each of the sites includes desktop pages and mobile pages. A routing service redirects mobile requests for the desktop pages to the mobile pages in accordance with a desktop-to-mobile mapping that defines an unbalanced correspondence between the desktop pages and the mobile pages. The routing service also redirects desktop requests for the mobile pages to the desktop pages in accordance with a mobile-to-desktop mapping that defines a balanced correspondence between them desktop pages and the mobile pages. 1. A collaboration service comprising:a plurality of collaboration sites that each comprise a plurality web pages, wherein the plurality of web pages comprises desktop pages and mobile pages; anda routing service that redirects mobile requests for the desktop pages to the mobile pages in accordance with a desktop-to-mobile mapping that defines an unbalanced correspondence between the desktop pages and the mobile pages and redirects desktop requests for the mobile pages to the desktop pages in accordance with a mobile-to-desktop mapping that defines a balanced correspondence between the desktop pages and the mobile pages.2. The collaboration service of wherein the routing service receives a plurality of requests for the plurality of web pages from a plurality of service clients and discriminates between those that comprise the mobile requests and those that comprise the desktop requests based on an identity of a source of each of the plurality of requests.3. The collaboration service of wherein the routing service looks-up the identity of the source in a table that identifies each of the plurality of service clients as a mobile client or a non-mobile client.4. The collaboration service of wherein the unbalanced correspondence between the desktop pages and the mobile pages comprises a many-to-one correspondence between a subset of the desktop pages and a one of the mobile pages.5. The ...

ENHANCED EVENT HANDLER ATTACHMENT

Systems, software, and methods are disclosed herein for implementing a template rendering engine that facilities enhanced event handler attachment when executed by a processing system in the context of a browser application. The template rendering engine examines hypertext markup language (HTML) code downloaded to the browser for templates encoded in the HTML code. When a template is encountered in the HTML code, the template rendering engine examines the template for event handling information indicative of at least an element to render in a web page and an event handler to attach to the element in the web page. The template rendering engine then produces new HTML code for the browser to consume when rendering the web page, the new HTML code comprising the element and the event handler attached to the element. 1. One or more computer readable storage media having program instructions stored thereon comprising a template rendering engine for facilitating enhanced event handler attachment that , when executed by a processing system in the context of a browser application , directs the processing system to at least:examine hypertext markup language code downloaded to the browser application for templates encoded in the hypertext markup language code;when a template is encountered in the hypertext markup language code, examine the template for event handling information indicative of at least an element to render in a web page and an event handler to attach to the element in the web page; andproduce new hypertext markup language code for the browser application to consume when rendering the web page, the new hypertext markup language code comprising the element and the event handler attached to the element.2. The one or more computer readable storage media of wherein the template rendering engine further directs the processing system to claim 1 , when the template is encountered claim 1 , retrieve a data object to encode the new hypertext markup language code based on ...

Automated internet based interactive travel planning and management system

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members.

AUTOMATED INTERNET BASED INTERACTIVE TRAVEL PLANNING AND MANAGEMENT SYSTEM

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members. 1. A travel management system for providing system members with access to a travel facility at a travel terminal , the system comprising:a central memory that stores member profile records of the system members, the central memory being accessible over a communications network, each member profile record including central member identification information of an associated system member, the central member identification information including at least unique identifying information of the profile record and an image of the member;a central server in communication with the central memory;a portable access device associated with each member profile record, the portable access device including (i) a central processing unit, (ii) a local memory storing local member identification information duplicative of information in the associated member profile record, including the unique identifying information and the image of the member; and (iii) a display that is able to display at least the locally stored image of the member at the travel terminal; anda security check at the travel terminal that includes (i) an identification information input device that receives input member identification from a presenting member in possession of the portable ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases 1. A method for binding human low affinity Fcγ receptors (FcγR) on effector cells comprising administering a recombinantly produced biomimetic composition to a population of effector cells , wherein the biomimetic composition comprises two or more human IgG4 Fc domains wherein each of the two or more IgG4 Fc domains is capable of binding to a human low affinity FcγR , wherein the biomimetic composition binds to two or more human low affinity FcγRs , and wherein the biomimetic composition does not comprise either an antigen binding domain or a non-immunoglobulin protein , and wherein the human low affinity FcγR is an FcγRIIA , an FcγRIM , an FcγRIIIA , or an FcγRIIIB receptor.2. The method of claim 1 , wherein each of the two or more human IgG4 Fc domains comprises an IgG4 CH2 domain claim 1 , and an IgG4 CH3 domain.3. The method of claim 1 , wherein at least one of the two or more human IgG4 Fc domains comprises an IgG4 hinge claim 1 , an IgG4 CH2 domain claim 1 , and an IgG4 CH3 domain.4. The method of claim 1 , wherein each of the two or more human IgG4 Fc domains comprises an IgG4 hinge claim 1 , an IgG4 CH2 domain claim 1 , and an IgG4 CH3 domain.5. The method of claim 1 , wherein each of the two or more human IgG4 Fc domains further comprises a tailpiece region claim 1 , and wherein the tailpiece region is an IgM CH4 domain.6. The method of claim 1 , wherein each of the two or more human IgG4 Fc domains further comprises a multimerization domain selected from the ...

CYSTEINE-OPTIMIZED STRADOMERS

The present disclosure involves biologically active proteins termed cysteine-optimized multimerizing stradomers. Thus, the present disclosure provides compositions and methods providing anti-autoimmune and anti-inflammatory activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases. 1. A cysteine-optimized multimerizing stradomer unit comprising (i) at least one IgG Fc domain; and (ii) at least one multimerization domain ,wherein the stradomer unit comprises at least two stradomer unit monomers and wherein at least one of the at least two stradomer unit monomers comprises at least one point mutation at a cysteine residue in the IgG Fc domain monomer or the multimerization domain monomer of the at least one stradomer unit monomer.2. The cysteine-optimized multimerizing stradomer unit of wherein the at least one IgG Fc domain is an IgG1 Fc domain.3. The cysteine-optimized multimerizing stradomer unit of wherein the IgG1 Fc domain comprises an IgG1 CH2 domain and an IgG1 CH3 domain.4. The cysteine-optimized multimerizing stradomer unit of further comprising an IgG1 hinge domain.5. The cysteine-optimized multimerizing stradomer unit of any one of - wherein the at least one multimerization domain is an IgG2 hinge domain.6. The cysteine-optimized multimerizing stradomer unit of wherein the IgG2 hinge domain is on the N-terminus of the IgG1 Fc domain.7. The cysteine-optimized multimerizing stradomer unit of wherein the IgG2 hinge domain is on the C-terminus of the IgG1 Fc domain.8. The cysteine-optimized multimerizing stradomer unit of claim 1 , comprising claim 1 , from amino to carboxy terminus claim 1 , an IgG1 Fc domain comprising an IgG1 hinge claim 1 , IgG1 CH2 and IgG1 CH3 domain and an IgG2 hinge.9. The cysteine-optimized multimerizing stradomer unit of any one of - wherein each of the at least two stradomer unit monomers comprise at least one point mutation at a cysteine residue in ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases 1. A method for binding low affinity Fcγ receptors (FcγR) on effector cells comprising administering a biomimetic composition to a population of effector cells , wherein the biomimetic composition comprises two or more Fc domains wherein each of the two or more Fc domains is capable of binding to a low affinity FcγR , wherein the biomimetic composition binds to two or more low affinity FcγRs , and wherein the biomimetic composition does not comprise either an antigen binding domain or a non-immunoglobulin-derived polypeptide other than an optional non-immunoglobulin-derived peptide linkage.2. The method of claim 1 , wherein each of the two or more Fc domains comprises an IgG CH2 domain claim 1 , and an IgG CH3 domain.3. The method of claim 1 , wherein at least one of the two or more Fc domains comprises an IgG hinge claim 1 , an IgG CH2 domain claim 1 , and an IgG CH3 domain.4. The method of claim 1 , wherein each of the two or more Fc domains comprises an IgG hinge claim 1 , an IgG CH2 domain claim 1 , and an IgG CH3 domain.5. The method of claim 1 , wherein the two or more Fc domains are derived from IgG1 claim 1 , IgG2 claim 1 , IgG3 claim 1 , or IgG4.6. The method of claim 1 , wherein each of the two or more Fc domains further comprises a tailpiece region claim 1 , and wherein the tailpiece region is derived from IgM or IgA.7. The method of claim 1 , wherein each of the two or more Fc domains further comprises a multimerization domain selected from the group consisting ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases 1. A method for binding human low affinity Fcγ receptors (FcγR) on effector cells comprising administering a recombinantly produced biomimetic composition to a population of effector cells , wherein the biomimetic composition comprises two or more human IgG3 Fc domains wherein each of the two or more IgG3 Fc domains is capable of binding to a human low affinity FcγR , wherein the biomimetic composition binds to two or more human low affinity FcγRs , and wherein the biomimetic composition does not comprise either an antigen binding domain or a non-immunoglobulin protein , and wherein the human low affinity FcγR is an FcγRIIA , an FcγRIIB , an FcγRIIIA , or an FcγRIIIB receptor.2. The method of claim 1 , wherein each of the two or more human IgG3 Fc domains comprises an IgG3 CH2 domain claim 1 , and an IgG3 CH3 domain.3. The method of claim 1 , wherein at least one of the two or more human IgG3 Fc domains comprises an IgG3 hinge claim 1 , an IgG3 CH2 domain claim 1 , and an IgG3 CH3 domain.4. The method of claim 1 , wherein each of the two or more human IgG3 Fc domains comprises an IgG3 hinge claim 1 , an IgG3 CH2 domain claim 1 , and an IgG3 CH3 domain.5. The method of claim 1 , wherein each of the two or more human IgG3 Fc domains further comprises a tailpiece region claim 1 , and wherein the tailpiece region is an IgM CH4 domain.6. The method of claim 1 , wherein each of the two or more human IgG3 Fc domains further comprises a multimerization domain selected from the ...

Immunoglobulin constant region fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases. 120.-. (canceled)21. A method of treating an autoimmune or inflammatory disease comprising administering to a subject in need thereof a composition comprising a cluster stradomer comprising at least two multimerized cluster stradomer units ,wherein each of said cluster stradomer units comprises at least one multimerizing region selected from an IgG2 hinge or an isoleucine zipper and at least one Fc domain comprising a CH2 domain and a CH3 domain from IgG1 or IgG3 or a combination thereof,wherein the multimerizing region(s) of the at least two cluster stradomer units multimerize to form the cluster stradomer, andwherein the cluster stradomer is capable of specifically binding to at least two Fc receptors.22. The method of claim 21 , wherein the cluster stradomer comprises two multimerized cluster stradomer units.23. The method of claim 21 , wherein the cluster stradomer comprises at least three multimerized cluster stradomer units.24. The method of claim 21 , wherein the cluster stradomer comprises at least four multimerized cluster stradomer units.25. The method of claim 21 , wherein the cluster stradomer comprises at least five multimerized cluster stradomer units.26. The method of claim 21 , wherein the at least one Fc domain comprises an IgG1 hinge claim 21 , an IgG1 CH2 domain claim 21 , and an IgG1 CH3 domain.27. The method of claim 21 , wherein the at least one Fe domain comprises an IgG3 hinge claim 21 , an IgG3 CH2 domain claim 21 , and an IgG3 CH3 domain.28. The ...

FUSION PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH ENHANCED COMPLEMENT BINDING

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves stradomers that increase multimerization and bind preferentially to complement and that are useful in the treatment and prevention of disease. 1. A stradomer unit comprising:(a) at least one IgG1 Fc domain with point mutations corresponding to positions 267, 268, and 324 of the IgG1 Fc domain; and(b) at least one multimerization domain.2. (canceled)3. The stradomer unit of claim 1 , wherein the Fc domain comprises the point mutations S267E claim 1 , H268F claim 1 , and S324T.4. The stradomer unit of claim 1 , wherein the Fc domain further comprises a point mutation at position 297.5. The stradomer unit of claim 4 , wherein the Fc domain comprises the point mutations S267E claim 4 , H268F claim 4 , N297A claim 4 , and S324T.619.-. (canceled)20. The stradomer unit of claim 1 , wherein the Fc domain further comprises a point mutation at position 236.21. The stradomer unit of claim 20 , wherein the Fc domain comprises the point mutations G236R claim 20 , S267E claim 20 , H268F claim 20 , and S324T.22. The stradomer unit of claim 1 , wherein the Fc domain further comprises point mutations at positions 233 and 236.23. The stradomer unit of claim 22 , wherein the Fc domain comprises the point mutations E233P claim 22 , G236R claim 22 , S267E claim 22 , H268F claim 22 , and S324T.2451.-. (canceled)52. The stradomer unit of claim 1 , wherein the Fc domain comprises either the EEM or DEL polymorphism of IgG1.5364.-. (canceled)65. The stradomer unit of wherein the multimerization domain is selected from the group consisting of an IgG2 hinge claim 1 , an isoleucine zipper claim 1 , and a GPP domain and is capable of multimerizing said stradomer units.66. The stradomer unit of ...

MANUFACTURING OPTIMIZATION OF GL-2045, A MULTIMERIZING STRADOMER

The present disclosure involves optimized methods for production of hiologically active proteins termed optimally manufactured stradomers. The present disclosure further provides compositions and methods useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.

AUTOMATED INTERNET BASED INTERACTIVE TRAVEL PLANNING AND MANAGEMENT SYSTEM

An interactive rapid response Internet accessed air travel management system. The system includes a web-based planning and reservation interface system and an interactive access device. The system responds to details of a member's desired travel, to thereafter act in real time to contact the domains of associated travel service providers to arrange for every aspect of the member's trip, from airline and hotel reservations, ticket issuance, and ground transportation, to restaurant and theater reservations, and any other travel related needs of the member. The system stores identification information to verify access device possession to prohibit unauthorized use of the system and to provide security pre-clearance to system members. 1. A travel management system for providing system members with access to a travel facility at a travel terminal , the system comprising:a central memory that stores member profile records of the system members, the central memory being accessible over a communications network, each member profile record including central member identification information of an associated system member, the central member identification information including at least unique identifying information of the profile record and an image of the member;a central server in communication with the central memory;a portable access device associated with each member profile record, the portable access device including (i) a central processing unit, (ii) a local memory storing local member identification information duplicative of information in the associated member profile record, including the unique identifying information and the image of the member; and (iii) a display that is able to display at least the locally stored image of the member at the travel terminal; anda security check at the travel terminal that includes (i) an identification information input device that receives input member identification from a presenting member in possession of the portable ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases. 1170-. (canceled)171. A method for treatment of a mammalian subject for an autoimmune or inflammatory disease , the method comprising:administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units;wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions;wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit;wherein the polymeric protein does not comprise a further immunomodulatory portion;or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.172. The method of wherein each polypeptide monomer unit comprises a tailpiece region fused to each of the two immunoglobulin G heavy chain constant regions;wherein the tailpiece region of each polypeptide monomer unit facilitates the assembly of the monomer units into a polymer.173. The method of wherein the tailpiece region is an IgM or IgA tailpiece claim 172 , or fragment or variant thereof.174. The method of wherein each of the immunoglobulin G heavy chain constant regions comprises an amino acid sequence having at least 90% sequence identity to a native human immunoglobulin G1 heavy chain constant region.175. The method of wherein each ...

TENSIONED AND EXPANDABLES EYEGLASSES

Disclosed are various embodiments for an eyeglass band comprising a plurality of layers, wherein at least one of the layers comprises a bistable or multistable band and at least one layer comprises a lens. The eyeglass band, via the spring band, may be elongated in a first fixed position when tension within the springy metal bands is created. When the tension within the springy metal bands is lost, the flexible bistable spring band will cause the bistable eyeglass apparatus to change to either a second position or a third position. The lens may be in an eyelevel position when the eyeglass band is worn on a face of a wearer. 1. A flexible eyeglass band comprising:a plurality of layers, at least one of the plurality of layers comprising a multistable spring body configured to transition from a first position to a second position to a third position, wherein the first position is an elongated position, the second position is a moderately coiled position, and the third position is a coiled position; and the eyeglass lens layer comprises at least one lens located at an eye level of the wearer; and', 'a first end and a second end of the flexible eyeglass band are positioned the temples of the wearer., 'wherein at least one of the plurality of layers comprises an eyeglass lens layer configured to conform to the multistable spring body during the transition from the first position to the second position to the third position, wherein, when worn in the second position by a wearer2. The flexible eyeglass band of claim 1 , further comprising two ear fasteners claim 1 , wherein each of the two ear fasteners is located at each end of the flexible eyeglass band.3. The flexible eyeglass band of claim 2 , wherein the two ear fasteners are capable of insertion into an interior of the flexible eyeglass band.4. The flexible eyeglass band of claim 1 , wherein the flexible eyeglass band is capable of a removal or an insertion of the at least one lens while the plurality of layers are ...

IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases. 1170-. (canceled)171. A core stradomer comprising a core moiety linked to at least two core stradomer units , wherein each of said at least two core stradomer units comprises at least one Fc domain , andwherein the core stradomer specifically binds to at least two Fcγ receptors through said at least two core stradomer units.172. The core stradomer of claim 171 , wherein the at least two Fc domains are IgG Fc domains.173. The core stradomer of claim 172 , wherein the at least two Fc domains comprise CH2 and CH3 domains independently selected from IgG1 claim 172 , IgG2 claim 172 , IgG3 claim 172 , and IgG4 CH2 and CH3 domains.174. The core stradomer of claim 173 , wherein the at least two Fc domains comprise IgG1 CH2 and CH3 domains.175. The core stradomer of claim 174 , wherein the IgG1 CH2 and CH3 domains comprise a variant amino acid sequence that is at least 95% identical to the native IgG1 amino acid sequence.176. The core stradomer of claim 175 , wherein the variant amino acid sequence alters the effector function of the core stradomer claim 175 , wherein the effector function is independently selected from the group consisting of:a. binding affinity for FcγRIIb;b. binding affinity for any FcγR;c. complement fixation;d. antibody-dependent cell-mediated cytotoxicity (ADCC);e. antibody-dependent cell-mediated phagocytosis (ADCP); andf. cytokine release.177. The core stradomer of claim 171 , wherein the core moiety is selected from the group comprising a bead claim 171 ...

FUSION PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH ENHANCED FC RECEPTOR BINDING

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to FcγRs and complement and that are useful in the treatment and prevention of disease. 176.-. (canceled)77. A homodimeric stradomer unit comprising:at least one homodimeric IgG1 Fc domain comprising two Fc domain monomers each comprising a point mutation corresponding to position 299 and further comprising one or more point mutations corresponding to at least one of positions 345, 430, or 440 of the Fc domain; andat least one multimerization domain.78. The homodimeric stradomer unit of claim 77 , wherein the Fc domain monomers comprise the point mutation T299A and one or more point mutations selected from E345R claim 77 , E430G claim 77 , and S440Y.79. The homodimeric stradomer unit of claim 77 , wherein the Fc domain comprises either the EEM or DEL polymorphism of IgG1.80. The homodimeric stradomer unit of claim 77 , wherein the multimerization domain is selected from the group consisting of an IgG2 hinge claim 77 , an isoleucine zipper claim 77 , and a GPP domain and is capable of multimerizing said homodimeric stradomer units.81. The homodimeric stradomer unit of claim 77 , wherein the multimerization domain creates multimers of the homodimeric stradomer units claim 77 , and wherein the multimers are higher order multimers.82. The homodimeric stradomer unit of claim 81 , wherein the higher order multimers comprise at least three homodimeric stradomer units.83. The homodimeric stradomer unit of claim 81 , wherein the higher order multimers comprise six claim 81 , twelve claim 81 , or eighteen homodimeric stradomer units.84. The homodimeric stradomer unit of claim 77 , wherein the homodimeric stradomer unit exhibits enhanced hexamer ...

Cartridge for label printer

In one embodiment, a cartridge body (2) for a cartridge (10) for providing media (1) to a printer (2100 includes a first part (4) and a complimentary second part (6), the first part and the second part formed of post-consumer-material; a hinge (3) integrally connected to the first part and the second part and adapted to close the first part and the second part together over the media and contain the media therein; and an opening (14) formed by the closed first part and second part for dispensing the media to the printer. A cartridge is also disclosed.

Tools for administering leagues and accessing and populating a community websitestructure

Immunoglobulin constant region FC receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Molecules with antigen binding and polyvalent fc gamma receptor binding activity.

La presente invención comprende proteínas biológicamente activas denominadas "stradobodies". Los stradobodies tienen dos o más dominios que crean multímeros de stradobodies. Los stradobodies tienen capacidad de unión al antígeno y la capacidad de unirse a receptores Fc (FcR), y son útiles para el tratamiento y la prevención de enfermedades.

Cysteine-optimized stradomers

The present disclosure involves biologically active proteins termed cysteine-optimized multimerizing stradomers. Thus, the present disclosure provides compositions and methods providing anti-autoimmune and anti-inflammatory activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.

Immunoglobulin constant region FC receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

A combined address and postage label and system for producing the same

A mailing label and system and method for preparing the same is provided. The mailing labels are provided on a continuous perforated strip (101), where the perforations (105) define unitary fields of labels (107), including at least a label for an intended recipient's address and a label for bearing a postal service approved postage indicia, to be used on a single item to be mailed. The strip is adapted for use with a computer driven printer (206) capable of printing the recipient's address, the postage indicia and other data relating to the item to be mailed on the labels within a given unitary field. The system and method according to the invention provide for the ability to prepare the aforementioned mailing labels effectively combining the functions of a postage meter with a system for preparing mailing labels.

Fusion Proteins of Natural Human Protein Fragments to Create Orderly Multimerized Immunoglobulin Fc Compositions

FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcyRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG 1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.

Tubular skylight with improved dome

A tubular skylight (10) having an improved dome (20) improving the efficiency of the skylight. The dome includes an integral prism in a portion (68) of its outer surface to reflect light downwardly through the skylight. The dome is hemispherical and the prism includes a plurality of grooves extending along great circles that pass through the apex of the dome. The prism covers only an angular segment of the hemispherical dome; and the grooves stop short of the apex of the dome.

Tubular skylight with improved dome

A tubular skylight (10) having an improved dome (20) improving the efficiency of the skylight. The dome includes an integral prism in a portion (68) of its outer surface to reflect light downwardly through the skylight. The dome is hemispherical and the prism includes a plurality of grooves extending along great circles that pass through the apex of the dome. The prism covers only an angular segment of the hemispherical dome; and the grooves stop short of the apex of the dome.

Improved brake mechanism for a device for drying foods and other items

A brake assembly for reducing the rotational velocity the spinning basket of a food spinning device applies a frictional force to an annular ridge on the lid of the spinning basket. A brake button movably disposed in a cover of the spinning device includes flexible pinching arms having cam surfaces. The cam surfaces of the flexible pinching arms extend through a guide aperture, thereby causing the pinching arms to flex toward each other when the brake button is depressed and to apply the frictional engagement to the annular ridge.

Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for Fc.gamma.Rs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.

Hybrid printer

Immunoglobulin constant region fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Immunoglobulin constant region Fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for Fc Rs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.

Methods of using immunoglobulin aggregates

The current invention provides a method of treating a mammal in need of such treatment with aggregated IgG derived from pooled human plasma. The invention further provides using the discarded fraction obtained during the course of standard IgG fractionation as the source of the aggregated IgG. The methods of the invention further provide for enhancing the aggregation of the aggregate fraction as well as enriching and modifying glycoforms.

Improved brake mechanism for a device for drying foods and other items

A brake assembly for reducing the rotational velocity the spinning basket of a food spinning device applies a frictional force to an annular ridge on the lid of the spinning basket. A brake button movably disposed in a cover of the spinning device includes flexible pinching arms having cam surfaces. The cam surfaces of the flexible pinching arms extend through a guide aperture, thereby causing the pinching arms to flex toward each other when the brake button is depressed and to apply the frictional engagement to the annular ridge.

Automated internet based interactive travel planning and management system

Coin stacking and packaging device

Cysteine-optimized stradomers

The present disclosure involves biologically active proteins termed cysteine-optimized multimerizing stradomers. Thus, the present disclosure provides compositions and methods providing anti-autoimmune and anti-inflammatory activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.

A combined address and postage label and system for producing the same

A mailing label and system and method for preparing the same is provided. The mailing labels are provided on a continuous perforated strip (101), where the perforations (105) define unitary fields of labels (107), including at least a label for an intended recipient's address and a label for bearing a postal service approved postage indicia, to be used on a single item to be mailed. The strip is adapted for use with a computer driven printer (206) capable of printing the recipient's address, the postage indicia and other data relating to the item to be mailed on the labels within a given unitary field. The system and method according to the invention provide for the ability to prepare the aforementioned mailing labels effectively combining the functions of a postage meter with a system for preparing mailing labels.

Tools for administering leagues and accessing and populating a community website structure

A website structure for populating the registration database of a website, such as myhome.com (102), and for providing access to information contained within various community areas that comprise the website. A plurality of community areas are provided via website pages which contain information pertaining to a registered user who will have a home page (272) with personal information. Other overlying community areas might provide group information to which a user belongs, or organization information to which a group belongs, and so forth. The information within the community areas can be viewed and shared by various users of the website, with access to the information controlled by the status of the user. The membership database for the website is built via invitations from member users to non-members users. An identification can be assigned to each relationship.

Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions.

La presente invención implica una serie de formas multimerizadas completamente recombinantes de Fc de inmunoglobulina que así presenta el Fc de inmunoglobulina polivalente a los receptores de las células inmune. Las proteínas de fusión existen tanto homodiméricas y fracciones multiméricas altamente ordenadas, denominadas estradómeros. En comparación con la fracción homodimérica, los estradómeros multiméricos purificados tienen mayor afinidad y avidez por los Fc?R con disociación más lenta y son útiles en el tratamiento y prevención de enfermedades. La presente invención demuestra que enlazar directamente las regiones Fc de IgG1 a dominios de multimerización conduce a multimerización y actividad biológica mejoradas.

Ace2-fc fusion proteins and methods of use

The present disclosure provides methods of treating and/or preventing viral infections comprising administering ACE2-Fc fusion proteins in combination with a second therapeutic agent, such as a monoclonal antibody.

Control of dual printing mechanisms

A printing system comprising: a printing device having first and second similar printing mechanisms; first and second similar holding means for holding respective first and second rolls of label stock in a position to pass the first and second printing mechanisms respectively; and a local processor connected to supply print data to a selected one of said first and second printing mechanisms and comprising means for receiving print data and a command for supplying said print data to the selected one of said first and second printing mechanisms to print an image on a label of the respective associated one of said first and second rolls of label stock, based on said command; and a host computer connected to the printing system and arranged to execute a common printer driver for supplying said print data and command to the printing device, regardless of which printing mechanism is selected.

Ace2-fc fusion proteins and methods of use

The present disclosure provides ACE2-Fc fusion proteins comprising an ACE2 extracellular domain or fragment thereof and one or more Fc domains and methods of use thereof.

Combined address and mailing label, as well as system for producing the same

Molecules with antigen binding and polyvalent fc gamma receptor binding activity

The current invention involves biologically active proteins termed stradobodies. The stradobodies have two or more domains that create stradobody multimers. The stradobodies have both antigen-binding capacity and the ability to bind Fc receptors (FcR), and are useful in the treatment and prevention of disease.

Immunoglobulin constant region fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions

Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced fc receptor binding

The present invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to Fc?Rs and complement and that are useful in the treatment and prevention of disease.

Immunoglobulin constant region fc receptor binding agents

Improved brake mechanism for a device for drying foods and other items

A printer

A printer comprises a printing mechanism arranged to print an image on an image receiving medium, wireless receiver means for receiving image data for printing on said image receiving medium. The wireless receiver means is arranged to receive signals having a frequency of the order of Gigahertz.

Improved brake mechanism for a device for drying foods and other items

A brake assembly for reducing the rotational velocity the spinning basket of a food spinning device applies a frictional force to an annular ridge on the lid of the spinning basket. A brake button movably disposed in a cover of the spinning device includes flexible pinching arms having cam surfaces. The cam surfaces of the flexible pinching arms extend through a guide aperture, thereby causing the pinching arms to flex toward each other when the brake button is depressed and to apply the frictional engagement to the annular ridge.

Cysteine-optimized stradomers

The present disclosure involves biologically active proteins termed cysteine-optimized multimerizing stradomers. Thus, the present disclosure provides compositions and methods providing anti-autoimmune and anti-inflammatory activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.

Immunoglobulin constant region Fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Compositions and methods for promoting hemostasis and other physiological activities

Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions

The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcyRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgGI Fc regions to multimerization domains leads to enhanced multimerization and biological activity.

HOMODIMERIC COMPOUND, DIMER OR MULTIMER OF A HIGHER ORDER OF HOMODIMERIC COMPOUND, COMPOSITION, COMPOUND, MULTIMER AND USES THEREOF

proteínas de fusão de fragmentos de proteína humana natural para criar composições de fc de imunoglobulina multimerizada ordenadamente. a presente invenção envolve uma série de formas multimerizadas completamente recombinantes de fc de imunoglobulina que, assim, apresentam fc de imunoglobulina polivalente para receptores de células imunes. as proteínas de fusão existem tanto como fracções homodiméricas quanto multiméricas altamente ordenadas, denominadas stradomers. em comparação com a fração homodimérica, os stradomers multiméricos purificados têm afinidade e avidez mais altas para fc rs com dissociação mais lenta e são úteis no tratamento e na prevenção de doenças. a presente invenção demonstra que ligando diretamente as regiões fc de igg1 aos domínios de multimerização leva a multimerização e atividade biológica intensificadas. fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions. The present invention involves a series of fully recombinant multimerized forms of immunoglobulin fc which thus present polyvalent immunoglobulin fc to immune cell receptors. fusion proteins exist as both homodimeric and highly ordered multimeric fractions, called stradomers. compared to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for slower dissociating fc rs and are useful in disease treatment and prevention. The present invention demonstrates that directly linking the fc regions of igg1 to the multimerization domains leads to enhanced multimerization and biological activity.

Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced complement binding.

La actual invención implica una serie de formas multimerizadas completamente recombinantes de Fc de inmunoglobulina que de ese modo presentan Fc de inmunoglobulina polivalente a los receptores de células inmunitarias. Las proteínas de fusión existen como fracciones multiméricas altamente ordenadas y homodiméricas, denominadas stradomers. La invención implica stradomers que aumentan la multimerización y se unen preferentemente al complemento y que son útiles en el tratamiento y prevención de enfermedades.

Methods of treating inflammatory disorders with multivalent fc compounds

The present invention provides methods for the identification of patients with an inflammatory or autoimmune disease that demonstrate an inadequate response to treatment with a multi-Fc therapeutic, and the determination of an optimal dose of a multi-Fc therapeutic for said patient based on the patient's circulating levels of inactivated C3b (iC3b) and/or additional complement components that may be employed as a surrogate for iC3b based on an analogous response to multi-Fc therapeutics. The present invention further provides for improvements in the use of such multi-Fc therapeutics in the treatment of autoimmune and inflammatory diseases

Fusion proteins of natural human protein fragments to create in an orderly fashion multimerized immunoglobulin FC compositions

A method of eliminating caking in materials andan improved material produced thereby

Manufacturing Optimization of GL-2045, a Multimerizing Stradomer

Manufacturing Optimization of GL-2045, a Multimerizing Stradomer ABSTRACT The present disclosure involves optimized methods for production of hiologically active proteins termed optimally manufactured stradomers. The present disclosure further provides compositions and methods useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.

Unbalanced mapping between desktop and mobile pages

Apparatus and method for detecting evapotranspiration

A method for detecting plant evapotranspiration includes: detecting, by an evapotranspiration (ET) sensor arranged in a canopy of a plant, a speed of air flowing through the canopy of plant, a temperature of the air and a relative humidity of the air over a plurality of time intervals; calculating, by a processor, an estimated mass flux of the air using at least one of a convective mass transfer (CMT) model, a mass balance (MB) model, or an empirical (EM) model; determining, by the processor, a plant scaling coefficient; integrating, by the processor, the estimated mass flux of the air over the plurality of time intervals to obtain a running sum; and multiplying, by the processor, the running sum by the plant scaling coefficient to determine an estimated evapotranspiration of the plant.