Use of bisphosphonic acid derivatives for preparing a medicine for treating lameness

Sponge having an open cavity

The present invention relates to a sponge (20) including at least one cavity (22), distinct from the pores of the sponge 5 (20), capable of allowing the introduction of a liquid inside the sponge (20) to impregnate the sponge (20), the cavity (22) preferably having a bottom (24) inside the sponge (20), and emerging on the other hand on a surface (26) of the sponge (20) while forming an opening (28) such that the maximum distance between two points of the contour of the opening (28) is comprised between 3, preferably 5, still more preferably 8, and 25, preferably 20, still more preferably 15 mm or still more preferably 12 mm.

Sponge having an open cavity

The present invention relates to a sponge ( 20 ) including at least one cavity ( 22 ), distinct from the pores of the sponge 5 ( 20 ), capable of allowing the introduction of a liquid inside the sponge ( 20 ) to impregnate the sponge ( 20 ), the cavity ( 22 ) preferably having a bottom ( 24 ) inside the sponge ( 20 ), and emerging on the other hand on a surface ( 26 ) of the sponge ( 20 ) while forming an opening ( 28 ) such that the maximum distance between two points of the contour of the opening ( 28 ) is comprised between 3, preferably 5, still more preferably 8, and 25, preferably 20, still more preferably 15 mm or still more preferably 12 mm.

DEBOUCHANTE CAVITY SPONGE

Sponge having an open cavity

La présente invention concerne une éponge (20) comportant au moins une cavité (22), distincte des pores de l'éponge (20), adaptée à permettre l'introduction d'un liquide à l'intérieur de l'éponge (20) pour imprégner l'éponge (20), la cavité (22) présentant de préférence un fond (24) à l'intérieur de l'éponge (20), et débouchant d'autre part sur une surface (26) de l'éponge (20) en formant un orifice (28) tel que la distance maximale entre deux points du contour de l'orifice (28) est comprise entre 3, de préférence 5, de préférence encore 8, et 25, de préférence 20 et de préférence encore 12 mm. The present invention relates to a sponge (20) having at least one cavity (22), distinct from the pores of the sponge (20), adapted to allow the introduction of a liquid inside the sponge (20) for impregnating the sponge (20), the cavity (22) preferably having a bottom (24) inside the sponge (20), and opening on the other hand to a surface (26) of the sponge (20) forming an orifice (28) such that the maximum distance between two points of the contour of the orifice (28) is between 3, preferably 5, more preferably 8, and 25, preferably 20, and preferably still 12 mm.

Use of bisphosphonic acid derivatives for preparing a medicine for treating lameness

L'invention concerne l'utilisation d'un dérivé de l'acide bisphosphonique de formule (I) dans laquelle: R1 représente un atome d'hydrogène, un atome d'halogène, un hydroxyle, un amino, un monoalkyl(C1-C4)amino, un dialkyl(C1- C4)amino; R2 représente un atome d'halogène, un alkyle linéaire comportant de 1 à 5 atomes de carbone non substitué ou substitué par un groupe choisi parmi un atome de chlore, un hydroxyle, un amino, un monoalkyl(C1-C4)amino, un dialkyl(C1-C4)amino; un cycloalkyl(C3-C7)amino, ou R2 représente un phénoxy, un phényle, un thiol, un phénylthio, un chlorophénylthio, un pyridyle, un pyridylméthyle, un 1-pyridyl-1-hydroxyméthyle, un imidazolylméthyle, un thiomorpholin-4-yle d'un de ses sels pharmaceutiquement acceptables ou d'un de ses hydrates dans la préparation d'un médicament destiné au traitement des boiteries apparaissant lors d'ostéo-arthrose, d'ostéochondrose, ou d'enthésopathies des insertions osseuses des tendons, des ligaments ou des aponévroses chez l'animal ne souffrant ni d'arthrite, ni de fractures, ni d'exostoses.

Sponge having an open cavity

The present invention relates to a sponge (20) comprising at least one cavity (22) that is separate from the pores of the sponge (20) and suitable for enabling a liquid to be fed to the inside of the sponge (20) in order to impregnate the sponge (20), wherein the cavity (20) preferably has a bottom (24) inside the sponge, and is in communication with a surface (26) of the sponge (20) while forming an opening (28) such that the maximum distance between two points of the outline of the opening (28) is between 3, preferably 5, and more preferably 8 and 25, preferably 20, and more preferably 12 mm.