Biomarkers for Follicular Thyroid Carcinoma and Methods of Use

The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same. 1. A method for determining whether a thyroid nodule in a subject is a follicular thyroid adenoma (FTA) or a follicular thyroid carcinoma (FTC) , said method comprising determining the abundance of a marker protein in a sample obtained from the subject , wherein the sample comprises a thyroid nodule , a tissue , a fluid sample , or a combination thereof , and wherein the marker protein comprises a protein of Table 1A , Table 2A , or a combination thereof , and wherein under abundance of the protein of Table 1A , over abundance of the protein of Table 2A , or a combination thereof is an indication that the thyroid nodule is malignant.2. The method of claim 1 , wherein said method comprises determining abundance of a plurality of proteins from Table 1A claim 1 , Table 2A or a combination thereof.3. The method of claim 1 , wherein the marker protein comprises HSP gp96 claim 1 , PDI A3 claim 1 , calreticulin claim 1 , or a combination thereof.4. The method of claim 1 , wherein the marker protein comprises at least two proteins.5. The method of claim 1 , wherein the marker protein comprises at least three proteins.6. The method of claim 1 , wherein said step of determining the abundance of a marker protein comprises comparing the protein level to a reference protein level.7. The method of claim 1 , wherein the reference protein level comprises a protein level in a subject having follicular thyroid adenoma (FTA).8. The method of claim 1 , wherein the reference protein level comprises a protein level in a subject having a follicular thyroid carcinoma (FTC).9. A method for determining whether a follicular-derived thyroid neoplasm in a subject is malignant or benign claim 1 , said method comprising:determining a level of a marker protein in a sample obtained from the subject, wherein the sample comprises a thyroid nodule, a tissue, ...

DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS

Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body. 1. A medical implant , comprising:an elongate implant body that includes a plurality of sheet segments, each of said sheet segments having a top surface, a bottom surface and at least one side edge, said at least one side edge having a greater surface porosity than said top surface and said bottom surface, the plurality of sheet segments being stacked in a generally longitudinal direction along the length of the implant body.2. The medical implant of further comprising an elongate element over which said sheet segments are received.3. The medical implant of claim 2 , wherein said elongate element includes a generally cylindrical body having a diameter in the range of about 3 mm to about 10 mm.4. The medical implant of claim 1 , wherein each of said sheet segments generally has a thickness in the range of about 0.2 mm to about 2 mm.5. The medical implant of claim 1 , wherein each of said sheet segments includes a multilayered construct incorporating 2 to about 10 layers of material.6. The medical implant of claim 1 , wherein said 2 to about 10 layers of material are fused to one another.7. The medical implant of claim 1 , wherein said ...

FLEXIBLE REINFORCED PIPE AND REINFORCEMENT TAPE

A flexible pipe includes: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape, the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer, the outer jacket including a thermoplastic. A reinforcing tape for use in the pipe or other applications includes: a plurality of reinforcing fibers and a matrix about the plurality of reinforcing fibers to hold the reinforcing fibers in the form of a tape, the matrix including thermoplastic and an additive to increase the impact resistance of the thermoplastic 1. A flexible pipe comprising: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape , the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer , the outer jacket including a thermoplastic.2. The flexible pipe of wherein the inner liner has an outer diameter to a wall thickness ratio of 30:1 to 50:1.3. The flexible pipe of wherein the inner liner is formed of a material including a thermoplastic and the first ply of reinforcing tape includes a matrix composition including a thermoplastic and the reinforcement layer is bonded to the inner liner by melt fusion of the ...

CONNECTION FOR A THERMOPLASTIC PIPE, ASSEMBLY AND METHOD

A pipe coupling for forming a pipe connection includes: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor. 1. A pipe coupling for forming a pipe connection , the pipe coupling comprising: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor.2. The pipe coupling of having an operating pressure range of from 50 to 103 bar.3. The pipe coupling of wherein the wall has a tubular laminate construction including a liner claim 1 , a reinforcement layer outwardly of the liner claim 1 , the reinforcement layer including at least one ply of reinforcing fibers and an outer jacket encircling the reinforcement layer.4. The pipe coupling of wherein the liner claim 3 , the reinforcement layer and the outer jacket each contain a thermoplastic.5. The pipe coupling of wherein the thermoplastic has at least one of the following characteristics: (i) a softening temperature greater than 100° C. claim 4 , (ii) a brittleness temperature less than −60° C. claim 4 , (iii) a melt temperature of 120 to 300° C. claim 4 , (iv) a tensile strength of 16 to 100 MPa claim 4 , (v) an elongation to break of at least 50% claim 4 , for example claim 4 , of 100 to 1000% claim 4 , (vi) resistance to fatigue cracking when subjected to 1 million cycles at 1% strain claim 4 , and (vii) a notched IZOD impact strength greater than 30 J/m.6. The pipe coupling ...

METHODS AND SYSTEMS FOR TREATING COMPLEX FISTULAE

Described, in certain respects, are unique methods and systems for treating fistulae and other passageways and openings in the body. In some embodiments, treatment will be performed on fistulae that include a passage extending through a subcutaneous wall or wall-like structure. Illustratively, such a passage can extend through a subcutaneous tissue wall that includes, at a minimum, portions of an intestinal wall, and in this regard, such a wall can have a first side that is provided by the luminal side of the intestines and a second subcutaneous side that is provided, for example, by the abluminal side of the intestines and/or by other subcutaneous tissues adhered to this abluminal side. Some inventive products and methods involve sealing off the passage from both sides of the wall, for example, where a sealing element is placed on each side of the wall over an opening to the passage. 1. A medical product for treating a fistulous passage that extends through a subcutaneous wall structure , the subcutaneous wall structure including a wall of the alimentary canal and having a first side that is provided by the luminal side of the alimentary canal wall and a second subcutaneous side that is opposite said first side , wherein the fistulous passage extends from an opening in the first side of the subcutaneous wall structure to an opening in the second side of the subcutaneous wall structure , the medical product comprising:a first capping arrangement deliverable to the first side of the subcutaneous wall structure and positionable over the opening in the first side of the subcutaneous wall structure while providing a first filling material in the fistulous passage;a guiding member extending from the first capping arrangement and extendable through the fistulous passage and through the opening in the second side of the subcutaneous wall structure when the first capping arrangement is positioned over the opening in the first side of the subcutaneous wall structure; anda ...

DATA TRANSFER DEVICE LIBRARY AND KEY DISTRIBUTION

A method of distributing a key to encrypt data for storing on a removable data storage item in a data transfer device library, the library comprising a controller having a key associated therewith and being connected to a plurality of data transfer devices each being operable to transfer data to a removable data storage item and having a key store, the method comprising: providing the key for the library to the controller; the controller providing the key to the key store of each data transfer device connected to the controller. A data transfer device library is also disclosed. 1. A method of distributing an encryption key to encrypt data for storing on removable data storage items in a data transfer device library that is connected to a plurality of data transfer devices each being operable to transfer data to one of the removable data storage items and having a key store , the method comprising:storing the encryption key in the library during manufacturing of the library;providing the encryption key to a controller in the library; andwriting the encryption key from the controller to each of the plurality of data transfer devices so each of the plurality of data transfer devices encrypt data to the removable data storage items using the encryption key.2. The method according to further comprising:storing, at a manufacturer of the library, the encryption key and an identification number of the library;supplying a replacement library as a recovery solution to a customer, the replacement library being pre-programmed with the encryption key to enable the customer to recover data stored on the removable data storage items.3. The method according to further comprising:shipping the library from a manufacturer to a customer with the encryption key stored in the library.4. The method according to claim 1 , wherein the data are encrypted in each of the plurality of data transfer devices using a block encryption technique in which each block of data is encrypted using the ...

DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS

Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body. 120-. (canceled)21. A medical implant , comprising:an elongate implant body including a plurality of sheet segments, each sheet segment of the plurality of sheet segments having a top surface, a bottom surface and at least one side edge, the plurality of sheet segments being stacked with the top surface of a first sheet segment facing the bottom surface of an adjacent sheet segment;wherein sheet segments of the plurality of sheet segments comprise a first material and a second material different from the first material.22. The medical implant of claim 21 , wherein:the first material comprises a naturally derived material and the second material comprises a non-naturally derived material.23. The medical implant of claim 22 , wherein:the naturally derived material comprises extracellular matrix (ECM) material.24. The medical implant of claim 23 , wherein:the non-naturally derived material comprises a biodegradable synthetic polymer.25. The medical implant of claim 24 , wherein:the plurality of sheet segments includes sheet segments comprising the extracellular matrix (ECM) material and other sheet segments comprising the biodegradable ...

RING DAM AND METHOD FOR MANUFACTURING A RING DAM

A ring dam, fitting between a fluid container and a housing for the fluid container, may include an extruded Polyethylene (EPE) foam having an Ethylene-Vinyl Acetate (EVA) additive. 1. A ring dam , fitting between a fluid container and a housing for the fluid container , comprising:an extruded Polyethylene (EPE) foam having an Ethylene-Vinyl Acetate (EVA) additive.2. The ring dam of wherein the EPE foam comprises a first end and a second end and wherein the first end and the second end are heat welded together to form a continuous ring.3. The ring dam of wherein the EPE foam comprises a central void.4. The ring dam of Claim of wherein the ring dam has a torus shape.5. The ring dam of wherein the central void has a torus shape.6. A method of manufacturing a ring dam claim 1 , fitting between a fluid container and a housing for the fluid container claim 1 , comprising the steps of:extruding Polyethylene (EPE) foam having an Ethylene-Vinyl Acetate (EVA) additive through a die;allowing the EPE foam to cure;cutting the EPE foam into a predetermined length, wherein the EPE foam has a first end and a second end; andheat welding the first end and the second end together to form a continuous ring.7. The method of manufacturing a ring dam according to wherein the predetermined length is no longer than the circumference or perimeter of the fluid container.8. The method of manufacturing a ring dam according to wherein the die is configured to impart a central void in the ring dam.9. The method of manufacturing a ring dam according to wherein the die is configured to impart a lateral cross-section in the ring dam having a furthest extent which is larger than a shortest distance between the fluid container and the housing.10. The method of manufacturing a ring dam according to wherein the furthest extent is in the range of 5 percent to 20 percent larger than the shortest distance.11. The method of manufacturing a ring dam according to wherein the die is configured to impart a ...

RADIOISOTOPE RECOVERY

The present invention relates to a method and an apparatus for separating and recovering a radioisotope from a solution. More particularly, certain embodiments of the invention relate to a method for recovering a radioisotope from a solution by electro-trapping and release using a microfluidic cell (). The radioisotope may subsequently be used in the preparation of radiopharmaceuticals. 1. A method for separating and recovering a radioisotope from an aqueous solution comprising the radioisotope , the method comprising:using a microfluidic device comprising a chamber;flowing the aqueous solution to the chamber, the chamber comprising a first electrode and a second electrode;generating a first electric field between the first and second electrodes, thereby trapping the radioisotope on the first electrode;flowing an organic-based solution to the chamber comprising the first and the second electrodes; andgenerating a second electric field between the first and the second electrodes;wherein the second electric field has an opposing polarity to the first electric field, thereby releasing the radioactive isotope from the first electrode into the organic-based solution; andwherein the first electrode is formed from a carbon rod or section thereof.2. The method of claim 1 , further comprising one or more of the features selected from:flowing the aqueous solution at a flow rate of at least 0.1 mL/min;flowing the organic-based solution at a flow rate of at least 0.05 mL/min;applying a voltage of no greater than 30 V across the first and second electrodes to generate the first electric field; andapplying a voltage of no greater than 10 V across the first and second electrodes to generate the second electric field.35-. (canceled)6. The method of claim 1 , wherein the chamber has a volume of no greater than approximately 50 μL.7. The method of claim 1 , wherein the first electrode has a flat surface comprising a plurality of recesses and/or the first electrode has a polished ...

System for radiopharmaceutical production

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Ferrous Nanoparticle Oil Extraction

Ferrous Nanoparticle Oil Extraction is the process of introducing ferrous nanoparticles coated in an oleophilic surfactant into oil reservoirs and implementing a magnetic force within the oil to supplement the traditional suctioning forces to extract oil. The nanoparticles, once in the oil, are allowed to disperse by Brownian motion and bind to the oil particles. The oil-nanoparticle solution is then magnetized and drawn out of the well. The magnetic force, originating at the mouth of the extraction pipe, supplements the traditional suctioning forces. Once collected, the oil-nanoparticle solution is passed through a high gradient magnetic separator, separating the oil from the nanoparticles. The nanoparticles are ready for reuse in the process of ferrous nanoparticle oil extraction.

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, collectors, kits, and methods for enhanced detection and quantification of analytes in collected fluid samples

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

CARTRIDGES, KITS, AND METHODS FOR ENHANCED MIXING FOR DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 1. A sample analysis cartridge comprising:an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample;a reservoir configured to hold a fluid, the reservoir further configured to receive the sample from the sample collection device; anda piezoelectric transducer that forms at least part of a wall of the reservoir, the piezoelectric transducer configured to emit energy into the reservoir to mix the fluid, the sample, and reagents.2. The sample analysis cartridge of claim 1 , further comprising a shuttle defining a first compartment and a second compartment claim 1 , the first and second compartments configured to be disposed within the reservoir in a mixing position.3. The sample analysis cartridge of claim 2 , wherein the shuttle is configured to move within the input tunnel such that the first and second compartments are not exposed to the fluid in the reservoir in a pre-mixing position.4. The sample analysis cartridge of claim 2 , wherein the piezoelectric transducer is configured to emit the energy into the reservoir to move the fluid in the reservoir in a wave pattern between the first and second ...

CIRCUIT BOARDS, CARTRIDGES HAVING THE SAME, KITS, AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 1. A microfluidic cartridge comprising:a reservoir configured to hold a fluid, the reservoir further configured to receive a sample from a sample collection device; and a sensor configured to generate a signal indicative of at least one of a presence, absence, or quantity of one or more analytes within the sample;', 'circuitry configured to be activated by insertion of the sample collection device; and', 'a temperature sensor positioned on the circuit board to sense temperature indicative of temperature of the fluid in the reservoir., 'a circuit board comprising2. The microfluidic cartridge of claim 1 , wherein the circuit board further comprises one or more spring contacts coupled to a piezoelectric transducer.3. The microfluidic cartridge of claim 2 , wherein the piezoelectric transducer is configured to emit energy into the reservoir to mix the fluid claim 2 , the sample claim 2 , and reagents.4. The microfluidic cartridge of claim 3 , wherein the piezoelectric transducer forms at least a part of a wall of the reservoir.5. The microfluidic cartridge of claim 4 , wherein the piezoelectric transducer is adhered to the reservoir to form at least the part of the wall using an annulus of adhesive applied on a top surface of ...

CARTRIDGES, KITS, AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 1. A sample analysis cartridge for detecting at least one of a presence , absence , or quantity of one or more analytes , the sample analysis cartridge comprising:an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample;a reservoir configured to hold a fluid;a shuttle disposed between the reservoir and the aperture in a first position, the shuttle having a first end and a second end, the shuttle configured to house a reagent ball comprising reagents between the first and second ends, the first end configured to seal the reservoir from the input tunnel in the first position, the shuttle configured to move within the input tunnel when subjected to a force greater than a threshold force to a second position such that the reagent ball and the sample move into the reservoir and the reservoir maintains the fluid therein during movement from the first position to the second position; anda sensor positioned to be exposed to the fluid mixed with the reagent ball and the sample, the sensor configured to generate a signal indicative of at least one of the presence, absence, or quantity of the one or more ...

CARTRIDGES, KITS, AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 1. A sample analysis cartridge comprising:an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample;a reservoir configured to hold a fluid, the reservoir further configured to receive the sample collected by the sample collection device;a collet disposed in the input tunnel between the reservoir and the aperture, the collet comprising a deflector portion and a lumen sized to receive the distal portion of the sample collection device therein; anda contact switch disposed adjacent the deflector portion of the collet,wherein the deflector portion is configured to deflect to activate the contact switch responsive to a force applied on the deflector portion by the sample collection device during insertion of the sample collection device in the input tunnel.2. The sample analysis cartridge of claim 1 , further comprising a shuttle disposed in the input tunnel between the reservoir and the aperture in a first position claim 1 , the shuttle configured to move within the input tunnel from the first position to a second position after the collet is decoupled from the shuttle such that the shuttle is at least ...

PROCESS FOR REDUCING MICROBIAL GROWTH IN CONTACT LENS STORAGE CASES

A method of disinfecting a contact lens storage case having a lid, the method comprising the steps of occluding the cavity of the case with the lid; and actively drying the case by heating the case for about three hours at about 60 degrees Celsius. 1. A method of disinfecting a contact lens storage case having a lid , the method comprising the steps of:occluding the cavity of the case with the lid; andactively drying the case by heating the case for about three hours at about 60 degrees Celsius.2. The method according to claim 1 , wherein the step of occluding the cavity of the case comprises one of:resting the lid on the case to thereby hide the cavity of the case;partially engaging the lid and the case; andfully engaging the lid and the case.3. The method according to claim 2 , where the step of partially engaging the lid and the case comprises partially engaging respective screw threads of the lid and the case.4. The method according to claim 2 , where the step of partially engaging the lid and the case comprises partially engaging respective press fit surfaces of the lid and the case.5. The method according to claim 2 , where the step of fully engaging the lid and the case comprises fully engaging respective screw threads of the lid and the case.6. The method according to claim 2 , where the step of fully engaging the lid and the case comprises fully engaging respective press fit surfaces of the lid and the case.7. The method according to claim 1 , wherein prior to the occluding and the actively drying steps the method comprises the further steps of:depositing a contact lens and an amount of disinfecting solution into the cavity of the case;fully engaging the lid and the case;subjecting the case to a time/temperature regime specified for the disinfecting solution;removing the contact lens; andmanually shaking out the disinfecting solution.8. The method according to claim 1 , wherein the actively drying step comprises actively drying the case by heating the case ...

CARTRIDGES, KITS, AND METHODS FOR ENHANCED DETECTION AND QUANTIFICATION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 127-. (canceled)28. A shuttle for delivering a sample and reagents to a reservoir of a microfluidic cartridge , the shuttle comprising:a body having a first end and a second end, the body sized to be disposed within an input tunnel of the microfluidic cartridge, the second end comprising an opening configured to receive a sample collected by a sample collection device;a sample compartment between the first end and the second end, the sample compartment configured to receive the sample through the opening of the second end; anda reagent ball compartment between the first end and the second end, the reagent ball compartment configured to house a reagent ball comprising reagents,wherein the shuttle is configured to move within the input tunnel when subjected to a force greater than a threshold force from a first position to a second position where the reagent ball compartment and the sample compartment are exposed to fluid in the reservoir.29. The shuttle of claim 28 , further comprising one or more beams that couple the first end to the second end claim 28 , andfurther comprising a compartment divider configured to divide the sample compartment from the reagent ball compartment, the compartment divider optionally including a ...

METHOD AND APPARAUS FOR THE ANALYSIS OF COMPOUNDS

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof. 1. A method of determining at least one characteristic of a sample comprising a compound , the method comprising:supplying the sample to a supply component of a microfluidic chip; wherein the sample has a volume of 10 ml or less;directing the sample or a portion thereof from the supply component via a microchannel which is in fluid communication with the supply component to a detection zone provided by the microfluidic chip; andperforming at least one analytical technique on the sample or the portion thereof at a detection zone,wherein the microfluidic chip comprises a plurality of detection zones, and wherein the method comprises performing an analytical technique at each detection zone.24-. (canceled)5. The method of claim 1 , wherein the sample has a volume selected from 500 μI or less claim 1 , 100 μI or less claim 1 , less than about 50 μI and 10 μI or less.6. (canceled)7. The method of claim 1 , further comprising obtaining a measurement value from the analytical technique and determining the at least one characteristic.8. The method of claim 7 , further comprising comparing the measurement value to a predetermined corresponding criterion value.9. The method of claim 1 , which is a method of quality control testing the sample.10. The method of claim 1 , wherein the compound is a radiopharmaceutical.11. The method of claim 10 , wherein:the radiopharmaceutical comprises a radioisotope selected from 18F, 99mTc, 11C, 89Zr, 64Cu and 68Ga; and{'sup': 18', '18', '18', '18', '18', '18', '18', '18 ...

Antimicrobial peptides and uses thereof

The present disclosure relates generally to antimicrobial peptides, methods for their use, and methods for preparing devices having surfaces which are modified to incorporate OH said peptides. In some embodiments, the antimicrobial peptides are antimicrobial OH cationic peptides modified to comprise a thiol functional group.

CARTRIDGES, KITS, AND METHODS FOR AMPLIFICATION AND DETECTION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. 1. A sample analysis cartridge comprising:an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample comprising a target nucleic acid;a reservoir configured to hold a fluid, the reservoir further configured to receive the sample from the sample collection device such that the sample is mixed with an effective amount of reagents for amplification of the target nucleic acid in the fluid of the reservoir to generate amplicons comprising signaling agents;an analysis channel configured to receive the fluid comprising the amplicons from the reservoir; anda sensor at least partially disposed in the analysis channel such that the amplicons indicative of at least one of a presence, absence, or quantity of the target nucleic acid in the sample localize over the sensor and the sensor senses signals indicative of at least one of the presence, absence, or quantity of the target nucleic acid in the sample based on reactions between a substrate and the signaling agents of the amplicons localized over the sensor.2. The sample analysis cartridge of claim 1 , further comprising reagent ball comprising the reagents for ...

Antimicrobial compounds

The present application relates to compounds of Formula (I) and salts thereof. The compounds of Formula (I) have antibacterial and anti-biofilm activities. The present application also relates to compositions comprising the compounds of Formula (I) or salts thereof, methods of treating or preventing bacterial infections using the compounds of Formula (I) or salts thereof, and methods of inhibiting biofilm formation using the compounds of Formula (I) or salts thereof.

CARTRIDGES, KITS, AND METHODS FOR AMPLIFICATION AND DETECTION OF ANALYTES

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

MALDI-TOF MS Method And Apparatus For Assaying An Analyte In A Bodily Fluid From A Subject

A method for assaying an analyte in a bodily fluid from a subject includes collecting a sample of the bodily fluid comprising an analyte of interest from a subject. A sample with the bodily fluid comprising the analyte of interest suitable for analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) is then prepared. Mass spectrometry is then performed to determine mass-to-charge ratios and ion abundances of the bodily fluid or its components. The mass-to-charge ratio values and the ion abundance of each of these ratios are then analyzed using calibration standards to interpret a resulting mass spectrum and to provide quantitative information. 1. A method for assaying an analyte of interest in a bodily fluid from a subject , the method comprising:a) collecting a sample of the bodily fluid comprising the analyte of interest from the subject;b) preparing the sample of the bodily fluid comprising the analyte of interest suitable for analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) mass spectrometry;c) performing MALDI-TOF mass spectrometry saving only spectra that exceed a predetermined intensity level;d) determining mass-to-charge ratios of the bodily fluid comprising the analyte of interest from the saved spectra; ande) analyzing the mass-to-charge ratios to interpret a resulting mass spectrum.2. The method of wherein the determining the mass-to-charge ratios of the bodily fluid comprising the analyte of interest from the saved spectra comprises averaging the saved spectra over a sample spot.3. The method of wherein the performing MALDI-TOF mass spectrometry comprises scanning ionizing light pulses across a predetermined area of the sample of the bodily fluid comprising the analyte of interest.4. The method of wherein the performing MALDI-TOF mass spectrometry comprises ionizing the sample of the bodily fluid comprising the analyte of interest with a laser and irradiating a spot on the ...

FLEXIBLE REINFORCED PIPE AND REINFORCEMENT TAPE

A flexible pipe includes: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape, the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer, the outer jacket including a thermoplastic. A reinforcing tape for use in the pipe or other applications includes: a plurality of reinforcing fibers and a matrix about the plurality of reinforcing fibers to hold the reinforcing fibers in the form of a tape, the matrix including thermoplastic and an additive to increase the impact resistance of the thermoplastic 1. A flexible pipe comprising: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape , the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer , the outer jacket including a thermoplastic.2. The flexible pipe of wherein the inner liner has an outer diameter to a wall thickness ratio of 30:1 to 50:1.3. The flexible pipe of wherein the inner liner is formed of a material including a thermoplastic and the first ply of reinforcing tape includes a matrix composition including a thermoplastic and the reinforcement layer is bonded to the inner liner by melt fusion of the ...

Cartridges, kits, and methods for amplification and detection of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

MONOLITHIC BODY

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body. 124.-. (canceled)25. A process for separating an analyte from a radioactive sample , comprising:eluting the sample through a chromatographic monolithic body,wherein the monolithic body is an inorganic monolithic body and is part of a microfluidic flow system.27. (canceled)28. A process for the manufacture of a monolithic module , comprising:i) supplying a mould for injection moulding containing an inorganic monolithic body;ii) injecting liquid polymer into the mould wherein the liquid polymer flows between a surface of the mould and a surface of the monolithic body and surrounds the monolithic body;iii) setting the polymer to form the monolithic module;iv) optionally annealing the monolithic module; andv) optionally providing an inlet and/or outlet, for example by machining the monolithic module.2930-. (canceled)31. The process according to claim 28 , further comprising:ii) injecting liquid polymer into the mould wherein the liquid polymer flows between a surface of the mould and a surface of the monolithic body and surrounds the monolithic body, except for the area of contact between the mould and monolithic body;iii) prior to setting the polymer to form the monolithic module, setting the polymer to form a partial monolithic module;iv) prior to setting the polymer to form the monolithic module, inserting the partial monolithic mould into a second mould for injection moulding; andv) prior to setting the polymer to form the monolithic module, injecting liquid polymer into the second mould wherein the liquid polymer flows between a surface of the mould and an exposed surface of the monolithic body to ...

Connection for a thermoplastic pipe, assembly and method

A pipe coupling for forming a pipe connection includes: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor.

Cartridges, kits, and methods for amplification and detection of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for amplification and detection of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for amplification and detection of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, collectors, kits, and methods for enhanced detection and quantification of analytes in collected fluid samples

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Cartridges, kits, and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Sealing system for the outlet of a plastic-lined compressed gas cylinder

A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. A tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal forming a tapered interface and a secondary seal. An axial position in the boss, and dimensional integrity, of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be formed on the insert.

PIPE CONNECTION DEVICE AND PROCEDURE

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Secured dispensing cabinet and methods

A device for dispensing items comprises a cabinet (10) having an interior fo r storing items. A dispenser frame (44) is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers (22) that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door (46) is coupled to the front of the cabinet in fro nt of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispenser drawer (38) is positioned below the storage area so that items dispensed from the dispensin g mechanisms may be retrieved

Connection for a thermoplastic pipe, assembly and method

A pipe coupling for forming a pipe connection includes: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor.

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Connection for a thermoplastic pipe, assembly and method

A pipe coupling for forming a pipe connection includes: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor.

Ring dam and method for manufacturing a ring dam

A ring dam, fitting between a fluid container and a housing for the fluid container, may include an extruded Polyethylene (EPE) foam having an Ethylene-Vinyl Acetate (EVA) additive.

Data transfer device library and key distribution

A method of distributing a key to encrypt data for storing on a removable data storage item in a data transfer device library, the library comprising a controller having a key associated therewith and being connected to a plurality of data transfer devices each being operable to transfer data to a removable data storage item and having a key store, the method comprising: providing the key for the library to the controller; the controller providing the key to the key store of each data transfer device connected to the controller. A data transfer device library is also disclosed.

Anti-extrusion sealing system for the outlet of a plastic-lined compressed gas cylinder

A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. Further, a tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal for compressing the liner outlet and closing any annular assembly clearance at the primary seal for obviating opportunity for seal extrusion under pressure. An axial position in the boss and dimensional integrity of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be integral with the boss. Reverse extrusion of the primary seal due to trapped gas and rapid decompression of the cylinder can be defeated by providing a leak path.

Flexible reinforced pipe and reinforcement tape

A flexible pipe includes: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape, the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer, the outer jacket including a thermoplastic. A reinforcing tape for use in the pipe or other applications includes: a plurality of reinforcing fibers and a matrix about the plurality of reinforcing fibers to hold the reinforcing fibers in the form of a tape, the matrix including thermoplastic and an additive to increase the impact resistance of the thermoplastic.

System for radiopharmaceutical production

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/ or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Anti-extrusion sealing system for the outlet of a plastic-lined compressed gas cylinder

Secured dispensing cabinet and methods

A device for dispensing items comprises a cabinet having an interior for storing items. A dispenser frame is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door is coupled to the front of the cabinet in front of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispense drawer is positioned below the storage area so that items dispensed from the dispensing mechanisms fall into the dispense drawer, where they may be accessed by pulling open the dispense drawer.

Multi-functional robot with remote and video system

A robot which incorporates a body, two arms, two legs, several sensors, an audio system, a light assembly, and a video device. The sensors located throughout the body of the robot combined with an edge detection sensor allows the robot to interact with objects in the room, and prevents the robot from traveling off an edge or bumping into obstacles. The audio system allows the robot to detect and transmit sounds. The video device allows a user to remotely view the area in front of the robot. Additionally, the robot may operate in a plurality of modes which allow the robot to operate autonomously. The robot may operate autonomously in an automatic mode, a security mode, a greet mode, and a monitor mode. Further, the robot can be manipulated remotely.

System for radiopharmaceutical production

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/ or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Biomarkers for diagnosis of breast cancer

The present invention provides methods and kits for determining breast cancer. The invention includes the identification and use of biomarkers that are present in different amount or differentially expressed in breast cancer versus normal controls.

Medical reinforcement graft

The embodiments described include graft devices for reinforcing patient tissue structures and methods of making and using the graft devices. In certain embodiments the graft devices have a remodelable extracellular matrix material graft body defining a slot and having a portion receivable through the slot to form a closed loop. Such graft devices can be used in encircling reinforcement of patient tissue structures such as anal sphincters or anastomosed vessel segments.

Anti-extrusion sealing system for the outlet of a plastic-lined compressed gas cylinder

A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. Further, a tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal for compressing the liner outlet and closing any annular assembly clearance at the primary seal for obviating opportunity for seal extrusion under pressure. An axial position in the boss and dimensional integrity of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be integral with the boss. Reverse extrusion of the primary seal due to trapped gas and rapid decompression of the cylinder can be defeated by providing a leak path.

Secured dispensing cabinet and methods

A device for dispensing items comprises a cabinet having an interior for storing items. A dispenser frame is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door is coupled to the front of the cabinet in front of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispense drawer is positioned below the storage area so that items dispensed from the dispensing mechanisms.

Safe and process supply cabinet

Un dispositivo para suministrar artículos, el dispositivo comprende: un gabinete (10) que tiene una parte delantera, una parte posterior, un par de lados y un interior que tiene un área de almacenamiento; una pluralidad de mecanismo (50) de suministro que se configuran para contener una pluralidad de artículos dentro del área de almacenamiento; un indicador (97) visual asociado con cada uno de los mecanismos (50 de suministro); y un ordenador (30) que se acopla en forma operable a los mecanismos (50) de suministro y los indicadores (97) visuales; caracterizado porque el gabinete (10) se construye de una estructura (12) de gabinete; el dispositivo comprende adicionalmente una unidad (42) de suministro que tiene una estructura (44) de unidad que se puede insertar en la estructura (12) de gabinete, dicha unidad (42) de suministro se asegura dentro de dicho gabinete (10); la estructura (44) de unidad comprende una estructura (48) de dispensador y un cajón (52) de suministro dispuesto por debajo de la estructura (48) de dispensador de tal manera que los artículos suministrados de los mecanismos (50) de suministro que se acoplan operablemente a la estructura (48) de dispensador caen en el cajón (52) de suministro; la estructura (48) de dispensador incluye una pluralidad de divisores (82), la estructura (48) de dispensador y la estructura (44) de unidad incluyen un sistema (68,70) de seguimiento para permitir que la estructura (48) de dispensador sea retirada de dicha estructura (44) de unidad; una puerta (46) bloqueable que se posiciona en la parte delantera de la estructura (48) de dispensador y acoplada a la estructura (44) unitaria; en el que la puerta (46) se puede operar para proporcionar acceso a la estructura (48) de dispensador; los divisores (82) se pueden reconfigurar en una posición deseada para permitir la disposición de los mecanismos (50) de suministro que se van a ajustar; un sistema de detección de divisor asociado con la estructura (48) de dispensador ...

Secured dispensing cabinet and methods

A device for dispensing items comprises a cabinet (10) having an interior for storing items. A dispenser frame (44) is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers (22) that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door (46) is coupled to the front of the cabinet in front of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispenser drawer (38) is positioned below the storage area so that items dispensed from the dispensing mechanisms may be retrieved

A stabiliser for whippable foods

A stabiliser composition for addition to a whippable food product comprises a soluble divalent cation, preferably calcium or magnesium. The stabilising composition interacts with a surfactant or protein present in the whippable food product to optimise its stabilising function. The soluble divalent cation may be in the form of calcium lactate, preferably at a concentration of 0.3-1.5% w/w in the resultant blend of food product and stabiliser. The resultant blend has a fat content of less that 20% (w/w). When the blend is whipped the fat content is less than 5% w/v. Advantageously the stabiliser composition also comprises a polysaccharide hydrocolloid selected from the group xanthan, methylcellulose and hydroxypropylmethylcellulose.

Treatment of inflammatory disease

The immunoglobulin heavy chain binding protein BiP (78KD), or a peptide derived therefrom provides a reagent for indicating the presence of rheumatoid arthritis. The protein used is recombinant BiP(78KD) having a defined sequence. A prognostic or diagnostic test for RA may be an ELISA assay or a Western Blot. The invention also includes a method of testing for RA, using a protein BiP(78KD) or a cDNA sequence coding therefor to determine the presence of antibodies to said protein. The invention also includes a method of therapeutic treatment of RA comprising administering the protein BiP(78KD) or a DNA coding therefor e.g. by the intravenous, nasal, oral, or cutaneous route.

SUPPLEMENTARY PREPARATIONS FOR POLYURETHANE FOAM

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry

The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.

Electrical supply system

C:\Rorth\CCUJR 4SU77_I DOC-1811/2 1 - 37 An electrical supply system including at least two electrical supply circuits, each supply circuit being adapted to supply electrical power to a number of electrical devices, at least one supply switch, each supply switch being for controlling the supply of electrical power to a respective electrical supply circuit, at least one input for selecting an operating mode and a controller coupled to the input and the at least one supply switch, the controller being for determining a selected operating mode and controlling the at least one supply switch in accordance with the selected operating mode to thereby selectively supply electrical power to at least one of the supply circuits. 311.1 321.1 321.2 314/ 32231. 313.2 ,,-312.3 313.3 302 '312.4 Fig. 3

Secured dispensing cabinet and methods

Biomarkers for Babesia

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.

Robot capable of autonomous operation

A robot which incorporates a body, arms with a hand grip, legs, several sensors, light elements, an audio system, and a video system. The sensors allows the robot to interact with objects in the room, and prevents the robot from traveling off an edge or bumping into obstacles. The light elements allow the robot to express moods. The audio system allows the robot to detect and transmit sounds. The video system allows a user to remotely view the area in front of the robot. Additionally, the robot may operate in a plurality of modes, including modes that allow the robot to operate autonomously. The robot may operate autonomously in an automatic mode, a security mode, a greet mode, and a monitor mode. Further, the robot can be manipulated remotely.

Biomarkers for follicular thyroid carcinoma and methods of of use

The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same.

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. coo C) C)) 0e 00 CYC" 1/50

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Behandlung von entzündungskrankheiten

Biomarkers for babesia

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.

Method and apparatus for the analysis of compounds

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Method and apparatus for the analysis of compounds

Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Novel antibacterial hydrogels

System for enhanced detection and quantification of analytes

Novel antibacterial hydrogels

The present invention relates to compounds of Formula I which form hydrogels upon mixing with water, and to fibers which form from the compounds. The hydrogels and fibers are antibacterial and not toxic towards mammalian cells. Such compounds, hydrogels, and fibers are useful, for example, in the treatment of surfaces such as in dermal or internal wounds as a barrier layer, or any article which may require disinfection. (I)

Carnosine analogs for use in the treatment of metabolic disorders

The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder, wherein R 1 is: a straight or branched C 1 -C 20 alkoxy, preferably C 1 -C 10 alkoxy group, optionally containing one or more rings, and/or optionally containing one or more double bonds; an alkoxycarbonyloxyalkoxy group bearing a straight, branched or cyclic alkyl; an aryloxy group; or an arylalkoxy group; R 2 and R 3 which can be the same or different, are: hydrogen; a straight or branched C 1 -C 20 alkylcarbonyl or cyclic C 3 -C 7 alkylcarbonyl group optionally containing one or more double bonds; an arylcarbonyl or arylalkylcarbonyl group; a straight or branched C 1 -C 10 alkoxycarbonyl or cyclic C 3 -C 7 alkoxycarbonyl group optionally containing one or more double bonds; an arylalkoxycarbonyl group; an amino group; a hydroxy group; or a group of general Formula (II) wherein Y is nitrogen, oxygen or sulfur and A is hydrogen or an amino group.

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Novel antibacterial hydrogels

The present invention relates to compounds of Formula I which form hydrogels upon mixing with water, and to fibers which form from the compounds. The hydrogels and fibers are antibacterial and not toxic towards mammalian cells. Such compounds, hydrogels, and fibers are useful, for example, in the treatment of surfaces such as in dermal or internal wounds as a barrier layer, or any article which may require disinfection. (I)

Novel antibacterial hydrogels

The present invention relates to compounds of Formula I which form hydrogels upon mixing with water, and to fibers which form from the compounds. The hydrogels and fibers are antibacterial and not toxic towards mammalian cells. Such compounds, hydrogels, and fibers are useful, for example, in the treatment of surfaces such as in dermal or internal wounds as a barrier layer, or any article which may require disinfection. (I)

Novel antibacterial hydrogels

The present invention relates to compounds of Formula I which form hydrogels upon mixing with water, and to fibers which form from the compounds. The hydrogels and fibers are antibacterial and not toxic towards mammalian cells. Such compounds, hydrogels, and fibers are useful, for example, in the treatment of surfaces such as in dermal or internal wounds as a barrier layer, or any article which may require disinfection. (I)

Improvements in machine belting

Compositions for use in the treatment of metabolic syndrome

The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder or for inducing weight loss: wherein R 1 is: H; a straight or branched alkyl; a straight or branched alkyl substituted with at least one moiety selected from the group comprising: halogen, hydroxy, alkoxy, NH 2 , mono- or disubstituted amino, thiol, and phosphine; aryl; aralkyl; hydroxy; alkoxy; aryloxy; arylalkoxy; NH 2 ; mono- or disubstituted amino; or halogen; X is: CH or N; L is absent or present, and when present is: an optionally substituted straight or branched C 1 -C 10 alkyl, optionally containing one or more rings, and/or optionally containing one or more double bonds; and Ar is: an optionally substituted 5-membered unsaturated heterocyclic ring.

Compound

Novel antibacterial hydrogels

A process for reducing microbial growth in contact lens storage cases

A method (300) of disinfecting a contact lens storage case (104) having a lid (101), the method comprising the steps of occluding (313) the cavity (113) of the case with the lid; and actively drying (315) the case by heating the case for about three hours at about 60 degrees Celsius.

A process for reducing microbial growth in contact lens storage cases

A process for reducing microbial growth in contact lens storage cases

Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry

The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.

Charged particle buncher

Improvements in machine belting

Carnosine Analogs for Use in the Treatment of Metabolic Disorders

The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder, wherein R1 is: a straight or branched C1-C20 alkoxy, preferably C1-C10 alkoxy group, optionally containing one or more rings, and/or optionally containing one or more double bonds; an alkoxycarbonyloxyalkoxy group bearing a straight, branched or cyclic alkyl; an aryloxy group; or an arylalkoxy group; R2 and R3 which can be the same or different, are: hydrogen; a straight or branched C1-C20 alkylcarbonyl or cyclic C3-C7 alkylcarbonyl group optionally containing one or more double bonds; an arylcarbonyl or arylalkylcarbonyl group; a straight or branched C1-C10 alkoxycarbonyl or cyclic C3-C7 alkoxycarbonyl group optionally containing one or more double bonds; an arylalkoxy carbonyl group; an amino group; a hydroxy group; or a group of general Formula (II) wherein Y is nitrogen, oxygen or sulfur and A is hydrogen or an amino group.

Biofilm-resistant coatings and surfaces

[UNK]

Systems and methods for enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.