02-01-2020 дата публикации
Номер: US20200000088A1
Принадлежит:
Novel antimicrobial compositions and kits thereof containing these antimicrobial compositions, methods of manufacture and methods of use thereof are disclosed. The novel aqueous transdermal or topical delivery systems are useful, inter alia, for treatment of various microbial infections, including for use on tissue infections, particularly skin antisepsis and/or nasal mucosal tissue antisepsis to a mammalian host in need thereof. 137-. (canceled)38. A method of disinfecting tissue comprising: an iodophor comprising a carrier selected from the group consisting of a polyvinylpyrrolidone, a copolymer of N-vinyl lactam, a polyether glycol, a polyvinyl alcohol, a polyacrylamide, a polysaccharide, and combinations thereof; wherein the iodophor is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;', 'a second antimicrobial agent;', 'a nonionic or anionic surfactant;', 'a thickening agent comprising a nonionic cellulose derivative or nonionic copolymer, or combination thereof; and', 'water;', said antiseptic composition is substantially free of any hydroxycarboxylic acid buffer; and', 'said antiseptic composition is substantially free of any fragrance; and, 'wherein], 'applying directly to tissue an antiseptic composition at use concentration, wherein the use concentration of the antiseptic. composition comprisesallowing the antiseptic composition to remain on the tissue; wherein the composition has a pH of 1.5 to 6.5.3941-. (canceled)42. A method according to wherein the nonionic copolymer comprises hydrophilic and hydrophobic regions.43. A method according to claim 42 , wherein the nonionic copolymer comprises a poloxamer.44. (canceled)45. A method of disinfecting skin of a subject comprising: prior to an invasive procedure claim 42 , [{'sub': '2', 'a first antimicrobial agent selected from the group consisting of I, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient ...
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