EXPAND-CASH MEDICAL BALLOONS AND PROCEDURES FOR YOUR PRODUCTION

Lubricious composition

A lubricious composition suitable for use on medical device, the composition including at least one alkoxylated acrylate compound having at least two acrylate groups per molecule and at least one second component which provides lubricity.

PHARMACEUTICAL ARTICLES COATED WITH LUBRICIOUS COATINGS

The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets. The coating comprises at least one hydrophilic polymer and at least one natural product, such as a natural polymer, a natural resin and/or a natural gum.

ZUSAMMENSETZUNGEN FÜR AUFZEICHNUNGSMATERIALIEN.

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers. 1. A medical device , comprising:a ventricular assist device (VAD) having a surface comprising an outermost layer of phosphorylcholine,wherein the outermost layer of phosphorylcholine has a thickness of less than 100 nanometers.2. The medical device of claim 1 , wherein the VAD comprises at least one of steel claim 1 , aluminum claim 1 , titanium claim 1 , cobalt claim 1 , chromium claim 1 , platinum claim 1 , nickel claim 1 , alloys thereof claim 1 , or combinations thereof.3. The medical device of claim 1 , wherein the phosphorylcholine is selected from the group consisting of 2-methacryloyloxyethyl phosphorylcholine claim 1 , 2-acryloyloxyethyl phosphorylcholine claim 1 , and phosphorylcholines based upon monomers including 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 3-(meth)acryloyloxypropyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 4-(meth)acryloyloxybutyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 5-(meth)acryloyloxypentyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 6-(meth)acryloyloxyhexyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(triethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(tripropylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(tributylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxypropyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxybutyl-2 ...

EXPANDIERBARE MEDIZINISCHE BALLONS UND VERFAHREN ZU IHRER HERSTELLUNG

ZUSAMMENSETZUNGEN FÜR AUFZEICHNUNGSMATERIALIEN.

Anti-thrombogenic medical devices and methods

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Lubricious coatings for pharmaceutical applications

The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets.

Lubricious coatings for pharmaceutical applications

The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets.

Lubricious coatings for medical applications

The invention provides pharmaceutical pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets.

Anti-thrombogenic medical devices and methods

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

PHARMACEUTICAL ARTICLES COATED WITH LUBRICIOUS COATINGS

The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets. The coating comprises at least one hydrophilic polymer and at least one natural product, such as a natural polymer, a natural resin and/or a natural gum.

Silk reinforcement of expandable medical balloons

A medical device formed from at least one first layer defining the shape of the medical device, the first layer having an inner surface and an outer surface and a web formed with silk fiber provided over at least a portion of the inner surface, the outer surface or both of the first layer.

Artificial silk reinforcement of PTCA balloon

A medical device formed from at least one first layer defining the shape of the medical device, the first layer having an inner surface and an outer surface and a web formed with silk fiber provided over at least a portion of the inner surface, the outer surface or both of the first layer.

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device. 1. A medical device , comprising:an expandable tubular body comprising a plurality of braided filaments configured to be implanted in a blood vessel, the braided filaments comprising a metal selected from the group consisting of platinum, cobalt, chromium, nickel, alloys thereof, and combinations thereof;wherein the filaments have an outer surface comprising a phosphorylcholine; andwherein the phosphorylcholine has a thickness of less than 100 nanometers.2. The medical device of claim 1 , wherein the phosphorylcholine is selected from the group consisting of 2-methacryloyloxyethyl phosphorylcholine claim 1 , 2-acryloyloxyethyl phosphorylcholine claim 1 , and phosphorylcholines based upon monomers including 2-(meth)acryloyloxyethyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 3-(meth)acryloyloxypropyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 4-(meth)acryloyloxybutyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 5-(meth)acryloyloxypentyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 6-(meth)acryloyloxyhexyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(triethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(tripropylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxyethyl-2′-(tributylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxypropyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 2-(meth)acryloyloxybutyl-2′-(trimethylammonio)ethyl phosphate claim 1 , 2-(meth) ...

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers. 1. A method comprising:forming an expandable tubular body comprising a plurality of braided filaments, the expandable tubular body is configured to be implanted in a blood vessel, the plurality of braided filaments comprising a first filament comprising platinum or platinum alloy and a second filament comprising cobalt-chromium alloy;applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament;applying a silane material to the second filament comprising the cobalt-chromium alloy, wherein the silane material comprises a silane selected from the group consisting of 3-glycidoxypropyltrimethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltriethoxysilane, 2-(3,4-epoxycyclohexyl)ethyl-trimethoxysilane, (3-glycidoxypropyl)trimethoxysilane, (3-glycidoxypropyl)triethoxysilane, 5,6-epoxyhexyltriethoxysilane, (3-glycidoxypropyl)methyldiethoxysilane, (3-glycidoxypropyl)methyldimethoxysilane, (3-glycidoxypropyl)dimethylethoxysilane, 3-isocyanatopropyltriethoxysilane, (isocyanatomethyl)methyldimethoxysilane, 3-isocyanatopropyltrimethoxysilane, tris(3-trimethoxysilylpropyl)isocyanurate, (3-triethoxysilylpropyl)-t-butylcarbamate, triethoxysilylpropylethylcarbamate, 3-thiocyanatopropyltriethoxysilane, and combinations thereof; andapplying a second phosphorylcholine material on the silane material on the second filament,wherein the first and second phosphorylcholine ...

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers. 125-. (canceled)26: A medical device , comprising: a substrate comprising at least one of cobalt, cobalt alloy, chromium, chromium alloy, nickel, or nickel alloy;', 'a silane layer comprising a silane material on the substrate; and', 'an outer coating comprising a phosphorylcholine material on the silane layer, wherein the outer coating defines a layer thickness of less than 10 nanometers., 'a braided vascular device comprising a plurality of braided filaments, wherein the braided vascular device is configured to be implanted in a blood vessel, and wherein at least some respective filaments of the plurality of braided filaments comprise27: The medical device of claim 26 , wherein the silane material comprises at least one of 3-glycidoxypropyltrimethoxysilane claim 26 , 2-(3 claim 26 ,4-epoxycyclohexyl)ethyltriethoxysilane claim 26 , 2-(3 claim 26 ,4-epoxycyclohexyl)ethyl-trimethoxysilane claim 26 , (3-glycidoxypropyl)trimethoxysilane claim 26 , (3-glycidoxypropyl)triethoxysilane claim 26 , 5 claim 26 ,6-epoxyhexyltriethoxysilane claim 26 , (3-glycidoxypropyl)methyldiethoxysilane claim 26 , (3-glycidoxypropyl)methyldimethoxysilane claim 26 , (3-glycidoxypropyl)dimethylethoxysilane claim 26 , 3-isocyanatopropyltriethoxysilane claim 26 , (isocyanatomethyl)methyldimethoxysilane claim 26 , 3-isocyanatopropyltrimethoxysilane claim 26 , tris(3-trimethoxysilylpropyl)isocyanurate claim 26 , (3- ...

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers. 1. A medical device , comprising: a substrate comprising at least one of cobalt, cobalt alloy, chromium, chromium alloy, nickel, or nickel alloy;', 'a silane material on the substrate; and', 'a phosphorylcholine material on the silane material,', 'wherein the phosphorylcholine material defines a thickness of less than 100 nanometers, and, 'a braided vascular device comprising a plurality of braided filaments, wherein the braided vascular device is configured to be implanted in a blood vessel, and wherein at least some respective filaments of the plurality of braided filaments comprise a time elapsed before onset of thrombin formation that is greater than about 1.5 times a time elapsed before onset of thrombin formation of a similar braided vascular device without the phosphorylcholine material,', 'a time elapsed before peak thrombin formation that is less than about 0.8 times a time elapsed before peak thrombin formation of a similar braided vascular device without the phosphorylcholine material, or', 'a peak thrombin concentration that is less than about 0.8 times a peak thrombin concentration of a similar braided vascular device without the phosphorylcholine material., 'wherein the braided vascular device exhibits at least one of2. The medical device of claim 1 , wherein the braided vascular device exhibits the time elapsed before onset of thrombin formation that is greater than about 1.5 ...

Anti-thrombogenic medical devices and methods

Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

Lubricious composition

A lubricious composition suitable for use on medical device, the composition including at least one alkoxylated acrylate compound having at least two acrylate groups per molecule and at least one second component which provides lubricity.

A flexible oligomer-containing photosensitive composition

Photoimageable compositions

A photoimageable composition includes a polymeric binder which is soluble in aqueous solution; a cross-linking agent for the polymeric binder; a polymerizable acrylic substance; a chemical, photosensitive, free radical-generating initiating system; and a liquid epoxy resin composition and an epoxy cure catalyst. In one method of using the photoimageable composition of the present invention, the composition is applied as a film to a substrate, heated to make the film non-tacky but still aqueous-soluble, exposed to actinic radiation, developed in aqueous solutions to wash away non-exposed portions of the film and heat-cured to harden the film.

Photoimageable composition having photopolymerizeable binder oligomer

An oligomer is provided having tetraacrylate functionality as well as carboxylic acid functionality. The oligomer is useful as a photopolymerizable binder in photoresists for forming printed circuitry. Particular advantages of the oligomer are found in solder mask-forming compositions which must withstand the conditions of nickel/gold plating.

Anti-thrombogenic medical devices and methods

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

ANTITROMBOGENIC MEDICAL DEVICES AND METHODS

dispositivos e métodos médicos antitrombogênicos. a presente invenção refere-se a métodos para aplicar camadas em dispositivos médicos, e dispositivos relacionados são fornecidos. tais dispositivos podem incluir stents. por exemplo, o dispositivo pode incluir uma parede lateral e uma pluralidade de poros na parede lateral, que são dimensionados para inibir o fluxo de sangue através da parede lateral para um aneurisma a um grau suficiente para levar a trombose e a cura do aneurisma quando o membro tubular é posicionado em um vaso sanguíneo e adjacente ao aneurisma. o dispositivo pode ter uma camada exterior antitrombogênica distribuída sobre pelo menos uma porção do dispositivo. antithrombogenic medical devices and methods. the present invention relates to methods for applying layers to medical devices, and related devices are provided. such devices may include stents. for example, the device may include a sidewall and a plurality of pores on the sidewall, which are sized to inhibit blood flow through the sidewall to an aneurysm to a degree sufficient to lead to thrombosis and aneurysm healing when the tubular limb is positioned in a blood vessel and adjacent to the aneurysm. the device may have an outer antithrombogenic layer distributed over at least a portion of the device.

Method of manufacturing anti-thrombogenic medical devices

The invention provides a method comprising: forming an expandable tubular body comprising a plurality of braided filaments, wherein the expandable tubular body is configured to be implanted in a blood vessel, and wherein the plurality of braided filaments comprises a first filament comprising platinum or platinum alloy and a second filament comprising cobalt-chromium alloy; chemically bonding a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament; applying a silane intermediate layer on the second filament comprising the cobalt-chromium alloy; and applying a second phosphorylcholine material on the silane intermediate layer on the second filament, wherein the first and second phosphorylcholine materials each define a respective thickness of less than 100 nanometers.

Silk reinforcement of expandable medical balloons

A medical device formed from at least one first layer defining the shape of the medical device, the first layer having an inner surface and an outer surface and a web formed with silk fiber provided over at least a portion of the inner surface, the outer surface or both of the first layer.

Photoimageable composition containing flexible oligomer

Expandable medical balloons and methods of preparing the same

Photoimageable compositions.

A photoimageable composition includes a polymeric binder which is soluble in aqueous solution; a cross-linking agent for the polymeric binder; a polymerizable acrylic substance; a chemical, photosensitive, free radical-generating initiating system; and a liquid epoxy resin composition and an epoxy cure catalyst. In one method of using the photoimageable composition of the present invention, the composition is applied as a film to a substrate, heated to make the film non-tacky but still aqueous-soluble, exposed to actinic radiation, developed in aqueous solutions to wash away non-exposed portions of the film and heat-cured to harden the film.

Photoimageable compositions

PHOTOIMAGEABLE COMPOSITIONS Abstract of the Disclosure A photoimageable composition includes a polymeric binder which is soluble in aqueous solution; a cross-linking agent for the polymeric binder; a polymerizable acrylic substance; a chemical, photosensitive, free radical-generating initiating system; and a liquid epoxy resin composition and an epoxy cure catalyst. In one method of using the photoimageable composition of the present invention, the composition is applied as a film to a substrate, heated to make the film non-tacky but still aqueous-soluble, exposed to actinic radiation, developed in aqueous solutions to wash away non-exposed portions of the film and heat-cured to harden the film.

Anti-thrombogenic medical devices and methods

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Expandierbare medizinische ballons und verfahren zu ihrer herstellung

Ein flexibles oligomer enthaltende, lichtempfindliche zusammensetzung

Anti-thrombogenic medical devices and methods

Anti-thrombogenic medical devices and methods

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Pharmaceutical articles coated with lubricious coatings

The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets. The coating comprises at least one hydrophilic polymer and at least one natural product, such as a natural polymer, a natural resin and/or a natural gum.

Zusammensetzungen für aufzeichnungsmaterialien.

Pharmaceutical articles coated with lubricious coatings

Materiale, hvorpaa der kan dannes et fotobillede, samt dets anvendelse

Materiale, hvorpaa der kan dannes et fotobillede, samt dets anvendelse