16-08-2018 дата публикации
Номер: US20180228900A1
Принадлежит:
Intervet Inc.
The present invention pertains to a composition containing an immunogenic cell preparation of killed bacteria in an ethylenediaminetetraacetic acid solution. The invention also pertains to a vaccine to protect an animal against an infection with bacteria, wherein the vaccine comprises this composition. Also, the invention pertains to the use of ethylenediaminetetraacetic acid to stabilise an immunogenic preparation of killed bacteria in a liquid carrier, by dissolving the ethylenediaminetetraacetic acid in the carrier. 111-. (canceled)12Leptospira. A composition containing an immunogenic cell preparation of killed bacteria in an ethylenediaminetetraacetic acid solution.13. The composition of claim 12 , wherein the solution comprises 5 to 50 mmols of ethylenediaminetetraacetic acid per litre.14. The composition of claim 13 , wherein the solution comprises 20 mmols of ethylenediaminetetraacetic acid per litre.15. The composition of claim 14 , wherein the solution contains dibasic sodium phosphate.16. The composition of claim 13 , wherein the solution contains dibasic sodium phosphate.17. The composition of claim 12 , wherein the solution contains dibasic sodium phosphate.18LeptospiraLeptospira interrogansLeptospira interrogansLeptospira kirschneri. The composition of claim 17 , wherein the bacteria are selected from the group consisting of serogroup Canicola serovar Portland-Vere claim 17 , serogroup Icterohaemorrhagiae serovar Copenhageni and serogroup Grippotyphosa serovar Dadas.19LeptospiraLeptospira interrogansLeptospira interrogansLeptospira kirschneri. The composition of claim 12 , wherein the bacteria are selected from the group consisting of serogroup Canicola serovar Portland-Vere claim 12 , serogroup Icterohaemorrhagiae serovar Copenhageni and serogroup Grippotyphosa serovar Dadas.20LeptospiraLeptospira interrogans. The composition of claim 19 , wherein the bacteria are serogroup Canicola serovar Portland-Ver.21. A vaccine to protect an animal against an ...
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