MIKTIONUNTERSTÜTZUNGSVORRICHTUNG

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 1/19 105 1K W7 102-&0 107 10 1006~~ FIG.1I

HIGH-FREQUENCY ELECTRICAL NERVE BLOCK

A method and apparatus that resulted in blocking an action potential in a nerve.

Percutaneous intramuscular stimulation system

A percutaneous, intramuscular stimulation system for therapeutic electrical stimulation of select muscles of a patient includes a plurality of intramuscular stimulation electrodes ( 50 ) for implantation directly into select muscles of a patient and an external battery-operated, microprocessor-based stimulation pulse train generator ( 10 ) for generating select electrical stimulation pulse train signals (T). A plurality of insulated electrode leads ( 40 ) percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes ( 50 ) to the external stimulation pulse train generator ( 10 ), respectively. The external pulse train generator ( 10 ) includes a plurality of electrical stimulation pulse train output channels (E) connected respectively to the plurality of percutaneous electrode leads ( 40 ) and input means ( 24,26,28 ) for operator selection of stimulation pulse train parameters (PA,PD,PF) for each of the stimulation pulse train output channels (E) independently ...

APPARATUSES AND METHODS FOR ADJUSTING A THERAPEUTIC ELECTRICAL DOSE

Apparatuses and methods of using them for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The methods and apparatuses described herein may include determining the dose based on a patient- specific database of previously delivered dose parameters and corresponding pre-delivery and post-delivery pain estimates from the patient.

PERCUTANEOUS INTRAMUSKULÄRES STIMULATION SYSTEM

Multi-frequency neural treatments and associated systems and methods

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. WO 2010/0188417 PCT/US20101022442 FMg.1I

APPARATUSES AND METHODS FOR SETTING AN ELECTRICAL DOSE

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient- specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. WO 2010/0188417 PCT/US20101022442 FMg.1I ...

MICTURITIONAL ASSIST DEVICE

... 2106008 9215366 PCTABS00016 Cuff electrodes (40a, 40b) are surgically implanted around S3 sacral ventral root nerve trunks (16a, 16b). The sacral ventral roots have smaller diameter nerve fibers (20a, 20b) which convey action potentials to cause detrusor activation to contract the bladder (10) and larger diameter nerve fibers (18a, 18b) which carry action potentials for causing contraction of a urethral sphincter (12) to block the flow of urine from the bladder. A current source (50) causes current pulses (52) between such electrical contacts (46, 48) and a central electrical contact (44). The current pulses have an appropriate amplitude and waveform to initiate action potentials adjacent the central contact and to block the propagation of action potential adjacent the end electrodes along the larger diameter nerve fibers (which have fewer nodes between the contacts) but not the smaller diameter nerve fibers (which have more nodes between the electrodes). In this manner, action potentials ...

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system

A method of treating shoulder dysfunction involves the use of a percutaneous, intramuscular stimulation system. A plurality of intramuscular stimulation electrodes are implanted directly into select shoulder muscles of a patient who has suffered a disruption of the central nervous system such as a stroke, traumatic brain injury, spinal cord injury or cerebral palsy. An external microprocessor based multi-channel stimulation pulse train generator is used for generating select electrical stimulation pulse train signals. A plurality of insulated electrode leads percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes to the external stimulation pulse train generator, respectively. Stimulation pulse train parameters for each of the stimulation pulse train output channels are selected independently of the other channels. The shoulder is evaluated for subluxation in more than one dimension. More than one muscle or muscle group is simultaneously subjected ...

Multi-frequency neural treatments and associated systems and methods

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system

A method of treating shoulder dysfunction involves the use of a percutaneous, intramuscular stimulation system. A plurality of intramuscular stimulation electrodes are implanted directly into select shoulder muscles of a patient who has suffered a disruption of the central nervous system such as a stroke, traumatic brain injury, spinal cord injury or cerebral palsy. An external microprocessor based multi-channel stimulation pulse train generator is used for generating select electrical stimulation pulse train signals. A plurality of insulated electrode leads percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes to the external stimulation pulse train generator, respectively. Stimulation pulse train parameters for each of the stimulation pulse train output channels are selected independently of the other channels. The shoulder is evaluated for subluxation in more than one dimension. More than one muscle or muscle group is simultaneously subjected to a pulse train dosage. Preferably, the at least two dosages are delivered asynchronously to two muscle groups comprising the supraspinatus in combination with the middle deltoid, and the trapezious in combination with the posterior deltoid.

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

Nerve cuff electrode for neuromodulation in large human nerve trunks

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Abstract A method for alleviating patient pain or discomfort, without relying on paresthesia or tingling to mask the patient's sensation of the pain, comprising: transmitting power from an external power source to an implanted portion of a therapy system that includes at least one electrode carried by a signal delivery device positioned in the patient's epidural space proximate to the patient's spinal cord region and outside the sacral region; and generating an electrical therapy signal via a signal generator, and delivering the therapy signal to the patient's spinal cord region via the at least one electrode, wherein the electrical therapy signal is at a frequency in a frequency range of from 2,500 Hz to 100,000 Hz.

PERCUTANEOUS INTRAMUSCULAR STIMULATION SYSTEM

A stimulation system includes a plurality of intramuscular stimulation electrodes (50) for implantation directly into select muscles of a patient and an external battery-operated, microprocessor-based stimulation pulse train generator (10) for generating select electrical stimulation pulse train signals (T). A plurality of insulated electrode leads (40) percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes (50) to the external stimulation pulse train generator (10), respectively. The external pulse train generator (10) includes a plurality of output channels (E) connected respectively to the plurality of percutaneous electrode leads (40) and input means (24, 26, 28) for operator selection of stimulation pulse train parameters (PA, PD, PF) for each channel (E) independently. Visual output means (20) provides visual output data to an operator of the pluse train generator (10). Non-volatile memory means (66, 68) stores the stimulation pulse train parameters ...

NERVE CUFF ELECTRODE FOR NEUROMODULATION IN LARGE HUMAN NERVE TRUNKS

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.

HIGH-FREQUENCY ELECTRICAL NERVE BLOCK

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 W7 102-&0 ...

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 W7 102-&0 ...

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 W7 102-&0 ...

Apparatuses and methods for adjusting a therapeutic electrical dose

Apparatuses and methods of using them for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The methods and apparatuses described herein may include determining the dose based on a patient- specific database of previously delivered dose parameters and corresponding pre-delivery and post-delivery pain estimates from the patient.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 W7 102-&0 ...

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulationsystem

Multi-frequency neural treatments and associated systems and methods

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Percutaneous intramuscular stimulation system

Apparatuses and methods for setting an electrical dose

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient- specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

PERKUTANES INTRAMUSKULÄRES STIMULATIONSSYSTEM

Percutaneous intramuscular stimulation system

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. WO 2009/061813 PCT/US2008/082472 W7 102-&0

Nerve cuff electrode for neuromodulation in large human nerve trunks

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.

Multi-frequency neural treatments and associated systems and methods

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

MIKTIONUNTERSTÜTZUNGSVORRICHTUNG

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 1. A method for treating a patient's pain , comprising:based at least in part on the value of a threshold frequency that corresponds to a refractory period for neurons of a target sensory neural population, selecting a target stimulation frequency that is above the threshold frequency; andproducing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the target stimulation frequency, with individual neurons of the target sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.285-. (canceled) The present disclosure is directed generally to systems and methods for producing asynchronous neural responses, such as for the treatment of pain and/or other disorders.Neurological stimulators have been developed to treat pain, movement disorders, functional disorders, spasticity, cancer, cardiac disorders, and various other medical conditions. Implantable neurological stimulation systems generally have an implantable pulse generator and one or more leads that deliver electrical pulses ...

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. 150-. (canceled)51. A method for alleviating a patient's pain , without relying on paresthesia or tingling to mask the patient's sensation of the pain , comprising:programming an implanted signal generator to generate and deliver an electrical therapy signal to a target location in the patient's spinal cord along the patient's dorsal column and superior to the sacral region via at least one electrode electrically coupled to the implanted signal generator and implanted in the patient's epidural spacewherein the electrical therapy signal has a frequency from 2,500 Hz to 100,000 Hz.52. The method of claim 51 , further comprising transmitting power from an external power source to an implanted internal power source electrically coupled to the signal generator.531011. The method of wherein programming the signal generator includes programming the signal generator to deliver the electrical therapy signal to at least one electrode located at vertebral level T or T.54. The method of wherein the electrical therapy signal is delivered to address low back pain.55. The method of wherein the electrical therapy signal is delivered to address leg pain.56. The method of claim 51 , further comprising:programming the implanted signal generator to also generate and deliver a paresthesia-inducing stimulation signal to the patient's spinal cord in combination with the electrical therapy signal,wherein the stimulation signal has a frequency in a frequency range ...

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 185-. (canceled)86. A therapy system for treating a patient's pain , comprising:a pulse generator coupled to a signal delivery element to transmit multiple electrical stimulation signals to the signal delivery element, the signal delivery element comprising a lead body including one or more electrodes; anda machine-readable medium within the pulse generator, the machine-readable medium containing instructions that, when executed, cause the pulse generator to transmit the multiple electrical stimulation signals to multiple neurons of a target sensory neural population via the signal delivery element, wherein the multiple electrical stimulation signals have a target stimulation frequency that is in a range from 3.0 kHz to 10 kHz, and wherein the multiple electrical stimulation signals produce an asynchronous sensory neuron response.87. The therapy system of claim 86 , wherein the target stimulation frequency is above a threshold frequency that corresponds to a refractory period for individual neurons of the target sensory neural population.88. The therapy system of wherein the multiple electrical stimulation signals delivered to the patient include a continuous string of bi-phasic ...

MIKTIONUNTERSTÜTZUNGSVORRICHTUNG

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 1. A method for treating a patient's pain , comprising:based at least in part on the value of a threshold frequency that corresponds to a refractory period for neurons of a target sensory neural population, selecting a target stimulation frequency that is above the threshold frequency; andproducing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the target stimulation frequency, with individual neurons of the target sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.285-. (canceled) This is a continuation application of U.S. patent application Ser. No. 13/857,960, filed Apr. 5, 2013, entitled SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS, which is a continuation application of U.S. patent application Ser. No. 13/544,727, filed Jul. 9, 2012, entitled SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS, which is a continuation application of U.S. ...

APPARATUSES AND METHODS FOR SETTING AN ELECTRICAL DOSE

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient-specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator. 1. An method of setting a therapeutic dose of a neuromodulator implanted into a patient , wherein the therapeutic dose comprises a therapeutic dose duration including a therapy ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage , the method comprising:applying a test voltage ramp from the neuromodulator implanted into the patient;determining a target sensation intensity modulation voltage that is specific to the patient from the test voltage ramp;estimating the peak modulation voltage as a function of the target sensation intensity modulation voltage and the therapy ramp-up time to reach the peak modulation voltage; andsetting the therapeutic dose using the estimated peak modulation voltage.2. The method of claim 1 , wherein the target sensation intensity modulation voltage is a maximum patient-tolerable modulation voltage3. The method of claim 1 , wherein the therapy ramp-up time to the peak modulation voltage is set to be half of the therapeutic dose duration.4. The method of claim 1 , wherein the therapeutic dose duration is set to be 30 minutes.5. The method of claim 1 , wherein determining the target sensation intensity modulation voltage comprises determining the voltage of the test voltage ramp being applied when a patient-reported ...

PERKUTANES INTRAMUSKULÄRES STIMULATIONSSYSTEM

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 185-. (canceled)86. A system for producing an asynchronous neural response , comprising: the first frequency is less than one half of a target stimulation frequency sufficient to produce the asynchronous neural response,', 'the second frequency is less than one half of the target stimulation frequency, and', 'the instructions, when executed, cause the pulse generator to transmit a plurality of paired pulses that produce the asynchronous neural response, wherein individual paired pulses comprise a first pulse of the first electrical stimulation signal separated by a phase shift from a second pulse of the second electrical stimulation signal; and, 'a pulse generator having a machine-readable medium containing instructions that, when executed, cause the pulse generator to transmit a first electrical stimulation signal having a first frequency, and a second electrical stimulation signal having a second frequency, wherein—'}a signal delivery element couplable to the pulse generator to deliver the first electrical stimulation signal and the second electrical stimulation signal to a target neural population.87. The system of wherein the instructions further cause the pulse generator to ...

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

NERVE CUFF ELECTRODE FOR NEUROMODULATION IN LARGE HUMAN NERVE TRUNKS

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve. 1. A nerve cuff electrode comprisinga plurality of conductive nerve contact segments, the segments having an inner surface contacting a nerve trunk and an outer surface not contacting the nerve trunk;at least a single wire of a conductive biocompatible material operatively connecting the plurality of conductive nerve contact segments thus forming a segmented strip, the wire configured as helical portions separated by non-helical portions where the non-helical portions are secured to the surface of the conductive nerve contact segments not contacting the nerve trunk; anda conductive lead capable of operatively connecting a waveform generator to at least one of the plurality of nerve contact segments.2. The electrode of where the wire helical portions are along the wire length between the conductive nerve contact segments.3. The electrode of where the wire non-helical portions are secured to the conductive nerve contact segments by a plurality of spot welds.4. The electrode of where the wire helical portions are embedded in a non-conductive material.5. The electrode of where the wire non-helical portion connects the conductive nerve contact segments.6. The electrode of further comprising a second wire operatively connecting the plurality of nerve contact segments claim 1 , the second wire generally parallel with the first wire.7. The electrode of where the conductive nerve contact segments are platinum.8. The electrode of where the wires are stainless steel.9. The electrode of where the non-conductive material is silicone.10. A nerve cuff electrode comprising:a plurality of platinum nerve contact segments, each nerve contact segment comprising an inner surface contacting a nerve trunk and an outer surface not contacting the nerve trunk;at least two wires of a conductive biocompatible material operatively connecting the plurality of platinum nerve contact segments thus ...

Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a universal external controller having a graphical user interface

The systems and methods provide effective neuromuscular stimulation to meet a host of different prosthetic or therapeutic objections. The systems and methods also provide convenience of operation, flexibility to meet different user-selected requirements, and transportability and ease of manipulation, that enhance the quality of life of the individual that requires chronic neuromuscular stimulation.

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Method of providing percutaneous intramuscular stimulation

A method selects a patient for therapeutic electrical stimulation of selected muscles. The patient is provided with a portable electrical pulse generator, which is coupled via an electrode cable assembly to intramuscular simulation electrodes percutaneously implanted directly into selected muscles of a patient. A clip connects the electrical pulse generator to the patient so that the electrical pulse generator and the electrode cable assembly coupled to the intramuscular stimulation electrodes ambulate with the patient. The electrical pulse generator is operated to apply therapeutic electrical stimulation of the selected muscles during ambulation of the patient. Periodically, the battery is replaced by releasing a battery access cover.

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 185-. (canceled)86. A system for applying neural stimulation to a patient , the system comprising:a pulse generator configured to generate an electrical stimulation signal having at least a first parameter value;an electrode array having one or more electrodes coupleable to the pulse generator,a sensor coupleable to the pulse generator and configured to be positioned proximate an anatomical feature of the patient; and deliver the electrical stimulation signal to a neural population of the patient via the one or more electrodes;', 'sense, via the sensor, a neural response generated by the neural population in response to the electrical stimulation signal;', 'determine a feedback value based on the sensed neural response from the neural population; and', 'based on the determined feedback value, automatically adjust the first parameter value of the electrical stimulation signal to a second parameter value different than the first parameter value., 'a machine-readable medium having instructions that, when executed, cause the system to—'}87. The system of wherein the feedback value corresponds to a relationship between the sensed neural response and a baseline level.88. The system of ...

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Multi-frequency neural treatments and associated systems and methods

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

HIGH-FREQUENCY ELECTRICAL NERVE BLOCK

A method and apparatus that resulted in blocking an action potential in a nerve.

Multi-Frequency Neural Treatments and Associated Systems and Methods

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

HIGH-FREQUENCY ELECTRICAL NERVE BLOCK

A method and apparatus that resulted in blocking an action potential in a nerve.

Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a universal external controller providing different selectable neuromuscular stimulation functions

The systems and methods provide effective neuromuscular stimulation to meet a host of different prosthetic or therapeutic objections. The systems and methods also provide convenience of operation, flexibility to meet different user-selected requirements, and transportability and ease of manipulation, that enhance the quality of life of the individual that requires chronic neuromuscular stimulation.

Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a universal external controller accommodating different control inputs and/or different control outputs

The systems and methods provide effective neuromuscular stimulation to meet a host of different prosthetic or therapeutic objections. The systems and methods also provide convenience of operation, flexibility to meet different user-selected requirements, and transportability and ease of manipulation, that enhance the quality of life of the individual that requires chronic neuromuscular stimulation.

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system

A method of treating shoulder dysfunction involves the use of a percutaneous, intramuscular stimulation system. A plurality of intramuscular stimulation electrodes are implanted directly into select shoulder muscles of a patient who has suffered a disruption of the central nervous system such as a stroke, traumatic brain injury, spinal cord injury or cerebral palsy. An external microprocessor based multi-channel stimulation pulse train generator is used for generating select electrical stimulation pulse train signals. A plurality of insulated electrode leads percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes to the external stimulation pulse train generator, respectively. Stimulation pulse train parameters for each of the stimulation pulse train output channels are selected independently of the other channels. The shoulder is evaluated for subluxation in more than one dimension. More than one muscle or muscle group is simultaneously subjected ...

Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using an external, battery powered controller with power conservation features

The systems and methods provide effective neuromuscular stimulation to meet a host of different prosthetic or therapeutic objections. The systems and methods also provide convenience of operation, flexibility to meet different user-selected requirements, and transportability and ease of manipulation, that enhance the quality of life of the individual that requires chronic neuromuscular stimulation.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

NERVE CUFF ELECTRODE FOR NEUROMODULATION IN LARGE HUMAN NERVE TRUNKS

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve. 1. A method of increasing durability of a nerve cuff electrode , the method comprising operatively connecting a plurality of segmented conductive contacts of the electrode with at least a single wire thus forming a segmented strip , the wire configured as helical portions separated by non-helical portions where the non-helical gap portions are secured to the surface of the conductive contacts , the helical portions permitting repeated electrode deformations without breaking and segmented conductive contacts resulting in decreased stress on contacts.2. The method of claim 1 , where the resisted deformations are selected from the group consisting of creases claim 1 , wrinkles claim 1 , breaks claim 1 , and combinations thereof.3. The method of claim 1 , where the helical portions are along the wire length between the conductive nerve contact segments.4. The method of claim 1 , where the non-helical portions are secured to the conductive nerve contact segments by a plurality of spot welds.5. The method of claim 1 , where the helical portions are embedded in a non-conductive material.6. The method of claim 1 , where the non-helical portion connects the conductive nerve contact segments.7. The method of further comprising a second wire operatively connecting the plurality of nerve contact segments claim 1 , the second wire generally parallel with the first wire.8. The method of claim 1 , where the conductive nerve contact segments are platinum.9. The method of claim 1 , where the wires are stainless steel.10. The method of claim 5 , where the non-conductive material is silicone.11. A nerve cuff electrode comprising:a plurality of conductive nerve contact segments, the segments having an inner surface configured to contact a nerve trunk and an outer surface configured not to contact the nerve trunk; andat least a single wire of a conductive biocompatible material ...

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. 1. A method for alleviating patient pain or discomfort , comprising:applying or instructing application of a high frequency blocking signal to the dorsal column of the patient,wherein the high frequency blocking signal is at a frequency in a frequency range of from about 2,500 Hz to about 100,000 Hz, andwherein the high frequency blocking signal inhibits or prevents the patient's sensation of pain without using paresthesia to mask the patient's sensation of pain.2. A method for alleviating patient pain or discomfort , comprising:applying or instructing application of a low frequency stimulation signal to the patient's spinal cord region, wherein the low frequency stimulation signal is at a frequency in a first frequency range of from about 40 Hz to about 500 Hz, and wherein the low frequency stimulation signal induces paresthesia to mask the patient's sensation of pain; andapplying or instructing application of a high frequency blocking signal to the patient's spinal cord region, wherein the high frequency blocking signal is at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz, and wherein the high frequency blocking signal alleviates the patient's discomfort resulting from the paresthesia.3. The method of claim 1 , wherein the frequency range is from about 2 claim 1 ,500 Hz to about 20 claim 1 ,000 Hz.4. The method of claim 1 , wherein the frequency range is from about 3 claim 1 ,000 Hz to about 10 claim 1 , ...

Multi-frequency neural treatments and associated systems and methods

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. 1. A method for treating patient pain , comprising: ["applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz; and", "applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz."], 'at least reducing patient pain by250-. (canceled) The present application is a continuation application of U.S. patent application Ser. No. 12/264,836, filed Nov. 4, 2008, which claims priority to U.S. Provisional Application 60/985,353, filed Nov. 5, 2007 and incorporated herein by reference.The present disclosure relates generally to methods and apparatuses for treating patient conditions, including chronic pain conditions via techniques that can include stimulating and blocking neuronal tissue associated with the spinal cord.Existing patient treatments include applying stimulation (e.g., up-regulating) signals to nerves, muscles or organs for treating a wide variety of medical disorders. Stimulation signal parameters (e.g., pulse width, frequency, and amplitude) are selected to initiate neural action potentials to be propagated along the nerve to an organ (e.g., brain or stomach).Down-regulating signals also can be applied to nerve fibers. Certain signal parameters can result in a signal that inhibits the nerve or blocks the ...

APPARATUSES AND METHODS FOR SETTING AN ELECTRICAL DOSE

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient-specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator. 1. A method of setting therapeutic doses of a neuromodulator implanted into a patient , wherein each of the therapeutic doses comprises a therapeutic dose duration including a therapy ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which voltage is sustained at the peak modulation voltage , the method comprising:applying a test voltage ramp from the neuromodulator implanted into the patient;determining a target sensation intensity modulation voltage that is specific to the patient from the test voltage ramp;calculating an estimated peak modulation voltage as a function of the target sensation intensity modulation voltage and the therapy ramp-up time to reach the peak modulation voltage;setting a first therapeutic dose using the estimated peak modulation voltage; andsetting a second therapeutic dose using a percentage of the estimated peak modulation voltage.2. The method of claim 1 , wherein the therapeutic dose duration of the first therapeutic dose is the same as the therapeutic dose duration of the second therapeutic dose.3. The method of claim 1 , wherein a duration of applying the estimated peak modulation voltage of the first therapeutic dose is greater than a duration of applying the estimated peak modulation voltage of the second therapeutic dose.4. The method of claim 1 , wherein the ...

SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal. 185-. (canceled)86. A method for automatically adjusting stimulation delivered to a patient , the method comprising:applying an electrical stimulation signal to a neural population of a patient to evoke a neural response generated by the neural population, wherein the electrical stimulation signal has a first parameter value;measuring the neural response evoked by the applied electrical stimulation signal;comparing the measured neural response to a prior level; andafter comparing the measured neural response to the prior level, automatically adjusting the first parameter value to a corresponding second parameter value based at least in part on the measured neural response.87. The method of claim 86 , further comprising repeating claim 86 , in a closed loop manner claim 86 , the operations of applying claim 86 , measuring claim 86 , comparing claim 86 , and adjusting until a target neural response is measured.88. The method of wherein the target neural response is an asynchronous response.89. The method of wherein measuring the neural response includes measuring a compound action potential of the neural population claim 86 , and wherein comparing the measured neural response ...

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

APPARATUSES AND METHODS FOR ADJUSTING A THERAPEUTIC ELECTRICAL DOSE

Apparatuses and methods of using them for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The methods and apparatuses described herein may include determining the dose based on a patient-specific database of previously delivered dose parameters and corresponding pre-delivery and post-delivery pain estimates from the patient. 1. A system for treating a patient's pain using high-frequency nerve block , the system comprising: one or more electrodes configured to apply high-frequency neural modulation to one or more nerves; and', 'a controller configured to apply a treatment dose having a set of treatment dose parameters from the one or more electrodes; and, 'an implantable neuromodulator comprising one or more processors;', 'a patient-specific dosing database of previously delivered doses and corresponding estimates of a change in patient-reported pain levels from before and after delivery of each dose; and', ["updating the patient-specific dosing database with the pre-delivery pain estimate from the patient, the post-delivery pain estimate from the patient, the set of treatment dose parameters corresponding to the pre-delivery pain estimate and the post-delivery pain estimate, and any adjustments made to the treatment dose parameters by the patient or the patient's caregiver during delivery; and", 'generating the set of treatment dose parameters based on the patient-specific database., 'a memory coupled to the one or more processors, the memory configured to store computer-program instructions, that, when executed by the one or more processors, perform a computer-implemented method comprising], 'a dose selector comprising2. The system of claim 1 , further comprising a user interface configured to allow patient entry of the pre-delivery pain estimate and the post-delivery pain estimate.3. The system of claim 2 , wherein the system is configured to prevent the controller from applying the treatment dose until the patient has ...

MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz. 150-. (canceled)51. A method for alleviating a patient's pain , comprising:programming an implanted signal generator to generate and deliver an electrical therapy signal to a target nerve fiber, via at least one electrode electrically coupled to the implanted signal generator, to alleviate the patient's pain,wherein the electrical therapy signal is at a frequency in a frequency range of from 2,500 Hz to 100,000 Hz, andwherein the signal generator is programmed to ramp a parameter in accordance with which the electrical therapy signal is generated.52. The method of wherein the signal generator is programmed to ramp the parameter over a time period in a range of from 3 milliseconds to 3 minutes.53. The method of wherein the signal generator is programmed to ramp the parameter up.54. The method of wherein the signal generator is programmed to ramp the parameter down.55. The method of wherein programming includes programming the implanted signal generator to generate and deliver the electrical therapy signal at an amplitude between 2 mA and 20 mA.56. The method of wherein the signal generator is programmed to ramp the amplitude of the electrical therapy signal.57. The method of wherein the amplitude is increased over a period of less than about ten seconds.58. The method of wherein the frequency range is from 3 claim 51 ,000 Hz to 10 claim 51 ,000 Hz.59. The method of wherein the signal generator is programmed to ramp the frequency of the ...

Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a programmable universal external controller

The systems and methods provide effective neuromuscular stimulation to meet a host of different prosthetic or therapeutic objections. The systems and methods also provide convenience of operation, flexibility to meet different user-selected requirements, and transportability and ease of manipulation, that enhance the quality of life of the individual that requires chronic neuromuscular stimulation.

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system

A method of treating shoulder dysfunction involves the use of a percutaneous, intramuscular stimulation system. A plurality of intramuscular stimulation electrodes are implanted directly into select shoulder muscles of a patient who has suffered a disruption of the central nervous system such as a stroke, traumatic brain injury, spinal cord injury or cerebral palsy. An external microprocessor based multi-channel stimulation pulse train generator is used for generating select electrical stimulation pulse train signals. A plurality of insulated electrode leads percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes to the external stimulation pulse train generator, respectively. Stimulation pulse train parameters for each of the stimulation pulse train output channels are selected independently of the other channels. The shoulder is evaluated for subluxation in more than one dimension. More than one muscle or muscle group is simultaneously subjected to a pulse train dosage. Preferably, the at least two dosages are delivered asynchronously to two muscle groups comprising the supraspinatus in combination with the middle deltoid, and the trapezious in combination with the posterior deltoid.

Systems for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

apparatus and methods for adjusting therapeutic electrical dose

“aparelhos e métodos para ajustar dose elétrica terapêutica”. os aparelhos e métodos de usá-los para definir uma dose terapêutica de um neuromodulador implantado em um paciente são descritos. os métodos e aparelhos descritos na presente invenção podem incluir a determinação da dose com base em um banco de dados específico do paciente de parâmetros de dose previamente aplicadas e correspondentes estimativas de dor pré e pós-aplicação do paciente.

Nerve cuff electrode for neuromodulation in large human nerve trunks

A nerve cuff electrode is disclosed. The nerve cuff electrode comprises a self-curling nerve cuff with a plurality of conductive nerve contact segments. The segments have an inner surface configured to contact a nerve trunk and an outer surface configured not to contact the nerve trunk. The nerve cuff electrodes comprise at least one wire of a conductive biocompatible material operatively connecting the plurality of conductive nerve contact segments thus forming a segmented strip. The wire is configured as helical portions separated by non-helical portions where the non-helical portions are secured to the surface of the conductive nerve contact segments configured not to contact the nerve trunk. The nerve cuff electrode comprises a conductive lead capable of operatively connecting a waveform generator to at least one of the plurality of nerve contact segments. The helical structure of the wire improves durability and flexibility of the cuff electrode.

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

High-frequency electrical nerve block

A method and apparatus that resulted in blocking an action potential in a nerve.

Multi-frequency neural treatments and associated systems

A therapy system for providing relief from chronic pain, configured to be arranged relative to the general anatomy of a spinal cord of a patient, wherein the therapy system includes:a pulse generator that is implantable subcutaneously within the patient and includes a computer-readable medium containing instructions,wherein the pulse generator is attached via a lead body to an electrode array including multiple electrodes carried by a support substrate ; orwherein the pulse generator is connected to percutaneous lead bodies, which are in turn connected to electrodes; andwherein the pulse generator is adapted to transmit the instructions and power to the electrodes to apply therapy signals to the nerve fibers of the patient to up-regulate and/or down-regulate the nerves;wherein the pulse generator is configured to generate high frequency blocking signals having a frequency ranging from 2,500 to 100,000 Hz and an amplitude from 2 mA to 20 mA.

Apparatuses and methods for adjusting a therapeutic electrical dose

Apparatuses and methods of using them for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The methods and apparatuses described herein may include determining the dose based on a patient- specific database of previously delivered dose parameters and corresponding pre-delivery and post-delivery pain estimates from the patient.

Multi-frequency neural treatments and associated systems and methods

A method and system for alleviating patient pain or discomfort, comprising: transmitting power from an external power source to an implanted portion of a therapy system that includes at least one electrode carried by a signal delivery device positioned in the patient's epidural space proximate to the patient's spinal cord region and outside the sacral region; and generating an electrical therapy signal via a signal generator, and delivering the therapy signal to the patient's spinal cord region via the at least one electrode, wherein the electrical therapy signal is at a frequency in a frequency range of from 2,500 Hz to 100,000 Hz. WO 2009/061813 PCT/US2008/082472 1/19 105 1K W7 102-&0 107 10 1006~~ FIG.1I

Perkutanes intramuskuläres stimulationssystem

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions

Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Apparatuses for setting an electrical dose

System for adjusting a therapeutic electrical dose

Apparatuses and methods for setting an electrical dose

Methods and apparatuses (e.g., devices, systems, etc.) for applying a therapeutic dose of electrical energy from a nerve cuff on the nerve to modulate nerve function, including reducing pain, may include using a normalized treatment dose value (or range of values) indicating a target therapeutic charge dose to be applied. These apparatuses and methods may use the impedance value of the nerve at the nerve cuff as well as the cross-sectional area of the region of the nerve at least partially surrounded by the nerve cuff in conjunction with the target normalized treatment dose value(s) to determine the parameters for applied energy. In particular, the parameters may be those needed to achieve high-frequency nerve block at the target normalized treatment dose value(s).

Apparatuses and methods for setting an electrical dose

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses may use a testing ramp to identify a peak modulation voltage that is patient-specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

Apparatuses and methods for setting an electrical dose

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient- specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

Multi-frequency neural treatments and associated systems

Apparatuses and methods for setting an electrical dose

Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient are described. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses described herein may use a testing ramp to identify a peak modulation voltage that is patient- specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

Apparatuses and methods for setting an electrical dose

Methods and apparatuses (e.g., devices, systems, etc.) for applying a therapeutic dose of electrical energy from a nerve cuff on the nerve to modulate nerve function, including reducing pain, may include using a normalized treatment dose value (or range of values) indicating a target therapeutic charge dose to be applied. These apparatuses and methods may use the impedance value of the nerve at the nerve cuff as well as the cross-sectional area of the region of the nerve at least partially surrounded by the nerve cuff in conjunction with the target normalized treatment dose value(s) to determine the parameters for applied energy. In particular, the parameters may be those needed to achieve high-frequency nerve block at the target normalized treatment dose value(s).

System for adjusting a therapeutic electrical dose

Nerve cuff electrode for neuromodulation in large human nerve trunks

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.

Apparatuses for setting an electrical dose

Multi-frequency neural treatments and associated systems

Nerve cuff electrode for neuromodulation in large human nerve trunks

A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.