03-05-2018 дата публикации
Номер: US20180118718A1
Принадлежит:
SELVITA S.A.
The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases. 2. The Compound according to claim 1 , or derivatives claim 1 , N-oxides claim 1 , prodrugs claim 1 , solvates claim 1 , tautomers or stereoisomers thereof as well as the physiologically acceptable salts of each of the foregoing claim 1 , including mixtures thereof in all ratios claim 1 ,wherein{'sup': '5', 'X denotes N—Ror O;'}{'sup': 1', 'X', 'X', 'X', 'Y', 'X', 'Y, 'Rdenotes Ar, Hetar, Ar—Ar, or Ar-Hetar;'}{'sup': 2', '3, 'Rand Rboth denote H;'}{'sup': 4', 'W', 'W', 'W', 'W', '4', 'W1, 'Rdenotes Aror Hetar, which Aror Hetarhas in its ortho-position, relative to the attachment of Rto X, one substituent Rand may or may not bear further substituents;'}{'sup': 5', 'X, 'Rdenotes H or LA;'}{'sup': W', 'W1', 'W2', 'W1', 'W2, 'Ardenotes a monocyclic aromatic ring system with 6 ring carbon atoms which ring system may bear, besides the ortho-substituent R, no further substituent or one further substituent R, wherein Rand Rmay be the same or different;'}{'sup': X', 'X1', 'X2, 'Ardenotes a monocyclic aromatic ring system with 6 ring carbon atoms which ring system may be unsubstituted or mono- or di-substituted with independently from each other Ror R;'}{'sup': X', 'Y1', 'X2, 'Ardenotes a monocyclic aromatic ring system with 6 ring carbon atoms which ring system may be unsubstituted or mono- or di-substituted with independently from each other Ror R,'}{'sup': W', 'W1', 'W2', 'W1', 'W2, 'Hetardenotes a monocyclic aromatic ring system with 5 or 6 ring atoms wherein 1, 2 or 3 of said ring atoms is/are nitrogen atom(s) and the remaining are carbon atoms, wherein ring system may bear, besides the ortho-substituent R, further substituent or one further substituent Rwherein Rand Rmay be the same or different;'}{'sup': X', 'X1', 'X2, 'Hetardenotes a mono- or bi-cyclic ...
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