Fluid delivery device

Device comprising a valve comprising a fluid circuit accommodated at least in part in a body, the circuit having an upstream extremity and a downstream extremity and at least one flow control means, the valve comprising an actuating means, the at least one control means comprising a flow regulator being situated in a section of the fluid circuit contained in a regulation module mounted in a removable manner on the body, the circuit comprising a first extremity opening onto the body at the level of a first orifice, the section of the fluid circuit of the regulation module being equipped with an upstream extremity comprising a first fluid connector configured for connection in a sealed manner at the level of the first orifice when the module is in position mounted on the body.

MULTI-ANGLE SLUDGE LANCE

A lancing crawler or head crawls along a no-tube lane (NTL) on a floor defining a reference plane oriented transverse to tubes of a steam generator, and has nozzles that generate lancing fluid jets along at least two different angles in the reference plane spaced apart by at least 45°. A rotational drive rotates the nozzles about an axis of rotation that may be offset from an axis of thrust imposed by the jets from the nozzles. An on-board sighting laser may be mounted with the nozzles, along with an on-board camera. A bladder expands to secure the lancing crawler or head between steam generator tubes adjacent the NTL. Each nozzle may include a taperlock seat. A nozzle tilt drive is configured to tilt the one or more nozzles respective to the reference plane. 1. A sludge lancing apparatus comprising:a lancing crawler or head configured to crawl along a no-tube lane (NTL) on a floor defining a reference plane oriented transverse to tubes of a steam generator; andone or more nozzles mounted on the lancing crawler or head and configured to generate lancing fluid jets along at least two different angles in the reference plane spaced apart by at least 45°.2. The sludge lancing apparatus of further comprising:a rotational drive configured to rotate the one or more nozzles about an axis of rotation that is transverse to the reference plane over an angular range spanning the at least two different angles.3. The sludge lancing apparatus of wherein the at least two different angles in the reference plane spaced apart by at least 45° include the angles 90° and one of 30° and 150° respective to a 0° reference along the NTL.4. The sludge lancing apparatus of wherein the at least two different angles in the reference plane spaced apart by at least 45° include the angles 90° claim 2 , 30° claim 2 , and 150° respective to a 0° reference along the NTL.5. The sludge lancing apparatus of further comprising:a drive track configured to move the lancing crawler or head along the NTL; ...

RECORD-BASED PLANNING IN OPERATIONAL MAINTENANCE AND SERVICE

In some implementations, there is provided a method, which includes receiving, at a recommendation system, a failure notice representing a failure detected by a sensor monitoring an object; comparing, by the recommendation system, the failure notice to a plurality of reference failure notices to identify at least one matching failure notice, the comparing based on a domain-by-domain scoring between the failure notice and the plurality of reference failure notices; and generating, by the recommendation system, a message including a suggested solution including at least one task to remedy the failure, the suggested solution obtained from the at least one matching failure notice. Related systems, methods, and articles of manufacture are also disclosed. 1. A method comprising:receiving, at a recommendation system, a failure notice representing a failure detected by a sensor monitoring an object;comparing, by the recommendation system, the failure notice to a plurality of reference failure notices to identify at least one matching failure notice, the comparing based on a domain-by-domain scoring between the failure notice and the plurality of reference failure notices; andgenerating, by the recommendation system, a message including a suggested solution including at least one task to remedy the failure, the suggested solution obtained from the at least one matching failure notice.2. The method of claim 1 , wherein the failure notice comprises a message received from the sensor comprising an Internet of Things sensor.3. The method of further comprising:receiving, at the recommendation system, a message representing the failure, wherein the message is received from a user equipment.4. The method of further comprising:determining the domain-by-domain scoring by at least determining a first score for a similarity between the object and objects in the plurality of reference failure notices, a second score for a similarity with respect to problem code in the failure notice and ...

BICHROMIC BIPODAL TRIPHENYLAMINE-BASED DYES WITH HIGH PHOTO-ELECTRON CONVERSION AT LOW LIGHT INTENSITIES

A bichromic bipodal triphenyl amine based dye of the following formula: 18-. (canceled)13. The process of wherein I) is N-bromosuccinimide (1.10 eq) claim 11 , THF-EtOAc (1:1) claim 11 , 2 days; II) Pd(PPh)(0.10 eq) claim 11 , NaOH (8 eq) claim 11 , THF:water (9:1) claim 11 , reflux 12 hours; III) cyanoacetic acid (4 eq) claim 11 , piperidine (0.25 eq) claim 11 , CHCb claim 11 , reflux 8 hours; IV) acetic acid:water (2:1) claim 11 , reflux 12 hours; V) 1) n-BuLi (1.2 eq) dropwise claim 11 , −78° C. dry THF 2) −78° C. 15 min 3) boronic ester (2 eq) one portion claim 11 , −78° C. 4) MeOH quench; VI) Ethylene glycol (3 mL) claim 11 , p-TsOH (0.2 eq) claim 11 , toluene (50 mL) claim 11 , Dean-Stark claim 11 , reflux overnight.14. The process of wherein I) is N-bromosuccinimide (1.10 eq) claim 12 , THF-EtOAc (1:1) claim 12 , 2 days; II) Pd(PPh)(0.10 eq) claim 12 , NaOH (8 eq) claim 12 , THF:water (9:1) claim 12 , reflux 12 hours; III) cyanoacetic acid (4 eq) claim 12 , piperidine (0.25 eq) claim 12 , CHCb claim 12 , reflux 8 hours; IV) acetic acid:water (2:1) claim 12 , reflux 12 hours; V) 1) n-BuLi (1.2 eq) dropwise claim 12 , −78° C. dry THF 2) −78° C. 15 min 3) boronic ester (2 eq) one portion claim 12 , −78° C. 4) MeOH quench; VI) Ethylene glycol (3 mL) claim 12 , p-TsOH (0.2 eq) claim 12 , toluene (50 mL) claim 12 , Dean-Stark claim 12 , reflux overnight.15. Use of the dye in a dye-sensitized solar cell (DSSC) at diffuse light levels lower than about 100 mWcm.16. Use of the dye in a dye-sensitized solar cell (DSSC) at diffuse light levels lower than about 100 mWcm.17. Use of the dye of in a dye-sensitized solar cell (DSSC) at diffuse light levels at about 25 mWcmto 5 mWcm.18. Use of the dye of in a dye-sensitized solar cell (DSSC) at diffuse light levels at about 25 mWcmto 5 mWcm.19. Use of the dye of in a dye-sensitized solar cell (DSSC) at diffuse light levels over than from about 10 mWcm.20. Use of the dye of in a dye-sensitized solar cell (DSSC) at diffuse light ...

VALVE FOR PRESSURIZED FLUID AND BOTTLE COMPRISING SUCH A VALVE

Valve for pressurized fluid including a body housing a fluid circuit having an upstream end and a downstream end, the circuit including a member for controlling the flow rate in the circuit, the member for controlling the flow rate being commanded by an actuating member, the actuating member being mounted in a mobile manner on the body of the valve between a rest position and an active position, the valve including at least one electronic functional member and a circuit breaker for commanding the electronic functional member, wherein the circuit breaker can be moved into at least two separate states, wherein the actuating member is configured to move the circuit breaker from a first state towards a second state during the movement thereof into at least one of the following positions: the rest position thereof, the active position thereof, or an intermediate position between these two positions. 1. A valve for pressurized fluid , comprising a body housing a fluid circuit having an upstream end configured to be connected to a pressurized fluid reserve and a downstream end configured to be connected to a receiving apparatus , the fluid circuit comprising a member for controlling the flow rate in the fluid circuit , the member for controlling the flow rate being commanded by an actuating member , mobile with respect to the body housing , the actuating member being mounted in a mobile manner on the body housing between a rest position in which the control member is arranged in a first state corresponding to a first value for flow rate in the fluid circuit and an active second position in which the actuating member moves the control member into a second state corresponding to a second value for flow rate in the fluid circuit , the valve comprising at least one electronic functional member and a circuit breaker for commanding the at least one electronic functional member , wherein the circuit breaker can be moved into at least two separate states , the actuating member ...

VALVE FOR PRESSURIZED FLUID

Valve for pressurized fluid, with or without an incorporated pressure relief device, including a body housing a fluid circuit having an upstream end intended to be connected to a pressurized fluid reserve and a downstream end intended to be connected to a receiving apparatus, the fluid circuit including a member for controlling the flow rate in the fluid circuit, the member for controlling the flow rate being commanded by an actuating member mobile with respect to the body of the valve, the valve including at least one electronic functional member arranged in a closed casing located on the body, wherein the casing includes a peripheral wall in communication with the exterior of the valve, the peripheral wall including at least 1. A valve for pressurized fluid , comprising a body housing a fluid circuit having an upstream end configured to be connected to a pressurized fluid reserve and a downstream end configured to be connected to a receiving apparatus , the fluid circuit comprising a member for controlling the flow rate in the fluid circuit , the member for controlling the flow rate being commanded by an actuating member mobile with respect to the body housing , the valve comprising at least one electronic functional member arranged in a closed casing located on the body housing , wherein the casing comprises a peripheral wall in communication with the exterior of the valve , said peripheral wall comprising at least one vent hole shut by a cover fixed on said peripheral wall.2. The valve of claim 1 , wherein the cover comprises an impervious plastic material layer stuck on said peripheral wall.3. The valve of claim 2 , wherein the plastic material layer is flexible.4. The valve of claim 2 , wherein the plastic material layer comprises at least one of the following: rubber claim 2 , a polymer.5. The valve of claim 1 , wherein the cover is locally thinned or partially pre-cut at or adjacent to the vent hole.6. The valve of claim 1 , further comprising at least two ...

IMPLEMENTING TRUSTED CLIENTS USING SECURE EXECUTION ENVIRONMENTS

Systems and methods for implementing trusted clients using secure execution environments. An example method comprises: receiving, by a server, a measurement from a client application running in a secure execution environment implemented by a client computing device; responsive to validating the measurement, transmitting a first confidential data item to the client application running in the secure execution environment; receiving, from the client application running in the secure execution environment, a second confidential data item derived from a local state of the client application modified by the first confidential data item; and updating, in view of the second confidential data item, a local state of a server application. 1. A method , comprising:receiving, by a server, a measurement from a client application running in a secure execution environment implemented by a client computing device;responsive to validating the measurement, transmitting a first confidential data item to the client application running in the secure execution environment;receiving, from the client application running in the secure execution environment, a second confidential data item derived from a local state of the client application modified by the first confidential data item; andupdating, in view of the second confidential data item, a local state of a server application.2. The method of claim 1 , wherein the first confidential data item comprises online game content.3. The method of claim 1 , wherein at least one of the client computing device is represented by a gaming device.4. The method of claim 1 , wherein the first confidential data item comprises executable code.5. The method of claim 1 , wherein the local state of the client application represents at least a part of a game session state.6. The method of claim 1 , further comprising:causing the client application running in the secure execution environment to forward the first confidential data item to a peer client ...

Automatic Movement and Activity Tracking

Computer-implemented systems and methods for classifying movement of an object are provided. Geolocation data for an object and timestamps associated with the geolocation data are processed to automatically identify a movement of the object. The movement is characterized by at least (i) timing data, and (ii) location data indicative of starting and ending locations of the object. One or more criteria for classifying the identified movement are accessed, where the one or more criteria are based on historical data for previous movements. An algorithm that evaluates the timing data and the location data of the identified movement against the one or more criteria is applied. The algorithm is configured to automatically assign a classification of a plurality of classifications to the identified movement based on the evaluation. A determination of whether to provide information on the identified movement to an output destination is made based on the assigned classification.

SELECTIVE RELEASE SYSTEM FOR TUMOR THERAPEUTIC AGENTS AND TUMOR DIAGNOSTIC AGENTS AND BIOSENSOR FOR TUMOR TISSUE

The present invention relates generally to a sensor for tumor tissue and a local release system for releasing therapeutic agents/diagnostic agents for targeted tumor therapy and diagnosis. More specifically, the invention relates to a cation-stabilised biopolymer gel, in particular an alginate gel, for use as a carrier matrix for a tumor therapeutic agent and/or tumor diagnostic agent, characterised in that the gel destabilises in the presence of a stimulus, in particular lysyl oxidase (LOX), generated by tumor cells or tumor tissue and the tumor therapeutic agent and/or tumor diagnostic agent can be released, and a pharmaceutical composition that comprises this cation-stabilised biopolymer gel with incorporated tumor therapeutic agent and/or tumor diagnostic agent and optionally an additional reporter substance. An associated aspect of the invention relates to an in vitro method for determining the presence and/or amount of a tumor-specific product in the body of a patient, characterised in that a physiological sample from a patient to whom a pharmaceutical composition according to the invention has been administered is examined to ascertain the presence and/or amount of a reporter substance that has been released after destabilisation of the gel as a result of contact with the tumor-specific product to be determined, and optionally compared with reference values. 1. A cation-stabilized biopolymer gel for use as a carrier matrix for a tumor therapeutic agent and/or tumor diagnostic agent , wherein the gel is capable of being destabilized in a presence of a stimulus generated by tumor cells or tumor tissue such that the tumor therapeutic agent and/or tumor diagnostic agent is released.2. The cation-stabilized biopolymer gel according to claim 1 , wherein the stimulus is lysyl oxidase (LOX) claim 1 , or a metalloprotease.3. The cation-stabilized biopolymer gel according to claim 1 , wherein tumor cells are claim 1 , or the tumor tissue is claim 1 , from tumors of the ...

VALVE FOR PRESSURIZED FLUID

A valve for a pressurized fluid, including a body housing a fluid circuit including an upstream end configured to be placed in communication with a reserve of pressurized fluid and a downstream end configured to be placed in communication with a receiver apparatus, the circuit including a control member controlling the flow rate in the circuit, said flow rate control member being operated by a mobile actuating member configured to move relative to the body of the valve, the valve including at least a first functional electronic member and a second functional electronic member, the second functional electronic member being mounted removably on the body of the valve. 115.-. (canceled)16. A valve for a pressurized fluid , comprising a body housing a fluid circuit comprising an upstream end configured to be placed in communication with a reserve of pressurized fluid and a downstream end configured to be placed in communication with a receiver apparatus , the circuit comprising a control member controlling the flow rate in the circuit , said flow rate control member being operated by a mobile actuating member configured to move relative to the body of the valve , the valve comprising at least a first functional electronic member and a second functional electronic member , the second functional electronic member being mounted removably on the body of the valve , wherein the valve comprises at least one housing configured to accommodate said second functional electronic member and an electrical contact(s) device configured to collaborate with a mating set of electrical contacts belonging to the second functional electronic member in order to provide electrical connection between the first functional electronic member and the second functional electronic member when the latter is in the position in which it is mounted on the body of the valve.1715. The valve as claimed in claim , wherein the second functional electronic member is configured to move translationally in a ...

DEVICE FOR SUPPLYING PRESSURIZED FLUID, AND ASSEMBLY FOR STORING PRESSURIZED FLUID, COMPRISING SUCH A DEVICE

Device for supplying pressurized fluid, including a first valve accommodating an internal fluid circuit, the device having a second valve having an internal circuit, the second valve forming a separate physical entity from the first valve, the first valve and the second valve having respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve, the internal circuits including a set of control valves for allowing or preventing the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system. 1. A device for supplying pressurized fluid , in particular pressurized gas , comprising a first valve accommodating an internal fluid circuit , the device comprising a second valve comprising an internal circuit , the second valve forming a separate physical entity from the first valve , the first valve and the second valve comprising respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve , the internal circuits comprising a set of control valves for allowing or preventing the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system , the device comprising at least one manually actuable movable control member for controlling the set of control valves , the control member being movable between a first , rest position , in which the flow of fluid towards the outlet is prevented , and a second , active position , in which the flow of fluid towards the outlet is allowed , the quick-connection system comprising a connection piece for connecting the second valve to the first valve , the connection piece being movable between a first position , in which the quick connection between the second valve and the first valve has not been established , and a second position , in which the ...

DEVICE FOR SUPPLYING PRESSURIZED FLUID, AND ASSEMBLY FOR STORING PRESSURIZED FLUID COMPRISING SUCH A DEVICE

A device for supplying pressurized fluid, including a first valve accommodating an internal fluid circuit, the device including a second valve including an internal circuit, the second valve forming a separate physical entity from the first valve, the first valve and the second valve including respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve, the internal circuits including a set of valves configured to allow or prevent the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system. 1. A device for supplying pressurized fluid , comprising a first valve accommodating an internal fluid circuit , the device comprising a second valve comprising an internal circuit , the second valve forming a separate physical entity from the first valve , the first valve and the second valve comprising respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve , the internal circuits comprising a set of valves configured to allow or prevent the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system , the device comprising at least one manually actuable movable control member for controlling the set of control valves , the control member being movable between a first , rest position , in which the flow of fluid towards the outlet is prevented , and a second , active position , in which the flow of fluid towards the outlet is allowed , the quick-connection system comprising a member for locking/unlocking the second valve on/from the first valve , the locking/unlocking member being movable between a first , unlocking position , when the quick connection between the second valve and the first valve as not been established , or allowing separation of the second valve and the ...

DEVICE FOR SUPPLYING PRESSURIZED FLUID, AND PRESSURIZED FLUID CYLINDER(S) COMPRISING SUCH A DEVICE

Device for supplying pressurized fluid, including a first valve housing an internal fluid circuit, the device including a second valve having an internal circuit and forming a physical entity distinct from the first valve. The first and the second valve including respective coupling members forming a detachable male/female quick-connection system for the second valve on the first valve. The two valves being configured such as to place their internal circuits in communication when the second valve is coupled to the first valve via the quick-connection system. 1. A device for supplying pressurized fluid , comprising a first valve housing an internal fluid circuit , the device comprising a second valve comprising an internal circuit) and forming a physical entity distinct from the first valve , the first and the second valve comprising respective coupling members forming a detachable male/female quick-connection system for the second valve on the first valve , the two valves being configured such as to place their internal circuits in communication when the second valve is coupled to the first valve via the quick-connection system , the internal circuits comprising an array of control valve(s) for controlling the circulation of the fluid towards an outlet the device comprising at least one manually actuatable movable command member for commanding the array of control valve(s) and/or the quick-connection system , the device comprising a member for purging one at least of the internal circuits , the purge member being in communication with the internal circuit or circuits on the one hand and with an exterior discharge zone , such as the atmosphere , on the other , the purge member being movable between a closed state preventing purging of the internal circuit or circuits towards the discharge zone and an open state allowing purging of the internal circuit or circuits towards the discharge zone , wherein the purge member comprises a check valve urged into a closure ...

ARRANGEMENT FOR CONDUCTING, TREATING AND/OR MEASURING A FLUID

A configuration for installation into a pipeline of a fluid network. The configuration has a connection housing with an inlet, an outlet, and a connection opening for connection of an exchangeable functional unit. The connection housing has a rotatably arranged core piece whose rotation makes it possible for the throughflow of the fluid through the connection housing to be blocked and/or released. The core piece has a receptacle for connection of the functional unit, and the receptacle and the connection opening are oriented in the same direction. 1. A configuration for installation into a pipeline of a fluid network , the configuration comprising:an exchangeable functional unit;a connection housing having an inlet, an outlet, and a connection opening formed therein for connection to said exchangeable functional unit; anda core piece rotatably disposed in said connection housing, a rotation of said core piece makes it possible for a throughflow of a fluid through said connection housing to be blocked or released, said core piece having a receptacle for connection of said exchangeable functional unit, said receptacle and said connection opening are oriented in a same direction.2. The configuration according to claim 1 , wherein said inlet and said outlet are disposed along a throughflow axis claim 1 , and a direction of connection of said exchangeable functional unit runs substantially orthogonally with respect to the throughflow axis.3. The configuration according to claim 1 , wherein said core piece has a core piece inlet and a core piece outlet disposed opposite said core piece inlet.4. The configuration according to claim 3 , wherein said core piece inlet and said core piece outlet are in each case connected to said receptacle.5. The configuration according to claim 3 , wherein by rotating said core piece inside said connection housing claim 3 , said inlet and said outlet of said connection housing claim 3 , and said core piece inlet and said core piece outlet of ...

PROVIDING SOCIAL ENDORSEMENTS WITH ONLINE ADVERTISING

Third-party publishers (such as websites) provide online advertisements combined with social endorsement information to users. A request for an advertisement is received from a viewing user via a third-party publisher system. A particular advertisement is selected in response to this request, and one or more advertisement tags associated with the advertisement are retrieved. The advertisement tags comprise information related to the advertisement. Social networking system data for users related to the viewing user is retrieved. Social endorsement information is obtained using the social networking system data and the advertisement tags associated with the advertisement. The social endorsement information and the advertisement are then combined and transmitted to the third-party publisher system, or are transmitted individually for combination by the third-party publisher system. 1. A computer-implemented method comprising:receiving a request for an advertisement at an advertisement server from a third-party publisher system in response to a request for content from a viewing user of the third-party publisher system, the advertisement server communicatively coupled to a social networking system that is independent from the third-party publisher system, the viewing user having previously established a connection with one or more additional users of the social networking system;accessing, by the advertisement server, one or more advertisement tags associated with an advertisement, wherein the advertisement tags comprise information related to the advertisement;accessing, by the advertisement server, social networking system data from the social networking system related to the one or more additional users connected to the viewing user and related to the advertisement tags;creating, by the advertisement server, a social endorsement based on the accessed social networking system data, the social endorsement indicating that one or more of the additional users have taken ...

ARRANGEMENT FOR INSTALLATION IN A FLUID LINE NETWORK, CONNECTOR AND FLUID METER

An arrangement for installation in a fluid line network contains a fluid meter having a housing with a fluid inlet and a fluid outlet, and a volume measuring part. At least one connector, which is intended for connection to the housing of the fluid meter, is either equipped with an additional function or configured for the adaptation of an additional function on the connector. The connector has a connector inflow and a connector outflow. The fluid meter and the connector form a modular unit that can be installed in the fluid line network. 1. A configuration for installing in a fluid line network , the configuration comprising:a fluid meter having a housing with a fluid inlet and a fluid outlet and a volume measuring part; andat least one connector connected to said housing of said fluid meter and equipped with an additional function or configured for an adaptation of the additional function on said connector, said connector having a connector inflow and a connector outflow, said fluid meter and said connector forming a modular unit that can be installed in the fluid line network.2. The configuration according to claim 1 , wherein said connector is one of a plurality of connectors forming a sub-modular unit with one another claim 1 , so that said fluid meter and said plurality of connectors form said modular unit that can be installed in the fluid line network.3. The configuration according to claim 1 , further comprising a functional module having a functional module housing claim 1 , said connector is connectable to said functional module.4. The configuration according to claim 3 , further comprising:a first plug-in connection is provided between said fluid meter and said connector; and/ora second a plug-in connection is provided between said connector and said functional module; and/ora third plug-in connection is provided between said fluid meter said functional module.5. The configuration according to claim 3 , wherein the additional function is provided by said ...

Combining Machine Learning With Domain Knowledge And First Principles For Modeling In The Process Industries

Computer-based process modeling and simulation methods and systems combine first principles models and machine learning models to benefit where either model is lacking. In one example, input values (measurements) are adjusted by first principles techniques. A machine learning model of the chemical process of interest is trained on the adjusted values. In another example, a machine learning model represents the residual (delta) between a first principles model prediction and empirical data. Residual machine learning models correct physical phenomena predictions in a first principles model of the chemical process. In another example, a first principles simulation model uses the process input data and predictions of the machine learning model to generate simulated results of the chemical process. The hybrid models enable a process engineer to troubleshoot the chemical process, enable debottlenecking the chemical process, enable optimizing performance of the chemical process at the subject industrial plant, and enable automated process control. 1. A computer-implemented method of process modeling and simulation , comprising:modeling a chemical process of a subject industrial plant, said modeling being by a processor and including generating a model that predicts progress of the chemical process; andbased on predictions made by the generated model, enabling improvements in performance of the chemical process at the subject industrial plant, the generated model including a hybrid model formed of a first principles model having at least one element enhanced by a machine learning model of the chemical process.2. A method as claimed in wherein the one element enhanced by a machine learning model is an input variable based on plant data claim 1 , and values of the input variable are augmented in training and developing the machine learning model.3. A method as claimed in further comprising:generating a dataset of variables based on first principles that augment original ...

Asset Optimization Using Integrated Modeling, Optimization, and Artificial Intelligence

System and methods that provide a new paradigm for solving process system engineering (PSE) problems using embedded artificial intelligence (AI) techniques. The approach can facilitate process model building and deployment and benefits from emerging AI and machine learning (ML) technology. The systems and methods can define PSE problems with mathematical equations, first principles and domain knowledges, and physical and economical constraints. The systems and methods generate a dataset of recorded measurements for variables of the process, and reduce the dataset by cleansing bad quality data segments and measurements for uninformative process variables from the dataset. The dataset is then enriched by, for example, applying nonlinear transforms, engineering calculations, and statistical measurements. The systems and methods use for example, a simplified first principles model (FPM), AI/ML model, or both in a hybrid model format to build a model and solution, which is deployed online to perform asset optimization tasks in real-time plant operations. 1. A method of building and deploying a model to optimize assets in an industrial process , the method comprising:generating a dataset by loading a set of process variables of a subject industrial process, each process variable including measurements related to at least one component of the subject industrial process;identifying and removing measurements that are invalid in quality for modeling a failure in the subject industrial process;enriching the dataset by deriving one or more feature variables and corresponding values based on the measurements of the set of process variables, and adding to the dataset the values corresponding to the one or more derived feature variables;identifying groups of highly correlated inputs by performing cross-correlation analysis on the dataset;selecting features of the dataset using (a) a representative input from each identified group of highly correlated inputs, and (b) measurements ...

Valve for pressurized fluid

Valve for pressurized fluid, with or without built-in pressure regulator, comprising a body (2) housing a fluid circuit (3) having an upstream end (4) intended to be placed in communication with a reserve of pressurized fluid and a downstream end (15) intended to be placed in communication with a receiver apparatus, the circuit (3) comprising a flow control member (6) for controlling the flow rate in the circuit (3), the said flow control member (6) being controlled by an actuating member (7) mobile with respect to the body (2) of the valve (1), the valve (1) comprising at least one first electronic functional member (101) and a second electronic functional member (8), the second electronic functional member (8) being mounted removably on the body (2) of the valve, characterized in that the valve (1) comprises at least one housing (5) intended to accommodate the said second functional electronic member (8) and an electrical contact(s) device (10) intended to collaborate with a mating set of electrical contact(s) (9) of the second electronic functional member (8) in order to provide an electrical connection between the first electronic functional member (101) and the second electronic functional member (8) when the latter is in position mounted on the body (2) of the valve.

Pressurized fluid supply device and pressurized fluid storage assembly (s) comprising such a device

Dispositif de fourniture de fluide sous pression, notamment de gaz sous pression, comprenant un premier robinet (3) abritant un circuit (13) interne de fluide, le dispositif (1) comportant un second robinet (5) comprenant un circuit (15) interne, le second robinet (5) formant une entité physique distincte du premier robinet (3), le premier (3) robinet et le second (5) robinet comprenant des organes (6, 7) d'accrochages respectifs formant un système de connexion rapide mâle/femelle amovible du second robinet (5) sur le premier (3) robinet, les circuits (13, 15) internes comprenant un ensemble de vanne(s) (4, 9) pour autoriser ou empêcher la circulation du fluide vers une sortie (25) du dispositif lorsque le second robinet (5) est accroché sur le premier robinet (3) via le système de connexion rapide, le dispositif (1) comprenant au moins un organe (11) de commande mobile actionnable manuellement pour commander l’ensemble de vanne(s), l’organe (11) de commande étant mobile entre une première position de repos dans laquelle la circulation de fluide vers la sortie (25) est empêchée et une seconde position active dans laquelle la circulation de fluide vers la sortie (25) est autorisée, le système de connexion rapide comprenant une pièce (14) de connexion du second robinet (5) sur le premier (3) robinet, la pièce (14) de connexion étant mobile entre une première position lorsque la connexion rapide n’est pas établie entre le second robinet (5) et le premier (3) robinet et une seconde position lorsque la connexion rapide est établie entre le second robinet (5) et le premier robinet (3), caractérisé en ce que, dans sa première position, la pièce (14) de connexion assure un blocage de l’organe (11) de commande dans sa première position de repos pour empêcher son déplacement vers sa seconde position active et en ce que, dans sa seconde position, la pièce (14) de connexion ne bloque pas l’organe (11) de commande dans sa première position de repos pour autoriser son dé ...

PRESSURE FLUID VALVE

Robinet pour fluide sous pression, avec ou sans détendeur de pression intégré, comprenant un corps (2) abritant un circuit (3) de fluide ayant une extrémité (4) amont destinée à être mise en relation avec une réserve de fluide sous pression et une extrémité (15) aval destinée à être mise en relation avec un appareil récepteur, le circuit (3) comprenant un organe (6) de contrôle du débit dans le circuit (3), ledit organe (6) de contrôle du débit étant commandé par un organe (7) d'actionnement mobile par rapport au corps (2) du robinet (1), le robinet (1) comprenant au moins un premier organe (101) fonctionnel électronique et un second organe (8) fonctionnel électronique, le second organe (8) fonctionnel électronique étant monté de façon amovible sur le corps (2) du robinet, caractérisé en ce que le robinet (1) comprend au moins un logement (5) destiné à accueillir ledit second organe (8) fonctionnel électronique et un dispositif (10) de contact(s) électrique(s) destiné à coopérer avec un jeu de contact(s) électrique(s) (9) conjugué du second organe (8) fonctionnel électronique, pour assurer une liaison électrique entre le premier organe (101) fonctionnel électronique et le second organe (8) fonctionnel électronique lorsque ce dernier est en position montée de sur le corps (2) du robinet. Pressurized fluid valve, with or without built-in pressure reducer, comprising a body (2) housing a fluid circuit (3) having an upstream end (4) for connection with a pressurized fluid reservoir and a downstream end (15) intended to be connected to a receiving apparatus, the circuit (3) comprising a flow control member (6) in the circuit (3), said flow control member (6) being controlled by an actuating member (7) movable relative to the body (2) of the valve (1), the valve (1) comprising at least a first electronic functional member (101) and a second electronic functional member (8), the second electronic functional member (8) being removably mounted on the body (2) of the ...

DEVICE FOR SUPPLYING FLUID UNDER PRESSURE

Dispositif de fourniture de fluide sous pression comprenant un robinet (3) raccordé à au moins réservoir (4) de gaz sous pression et muni d'un chapeau (2) de protection du robinet (3), le chapeau (2) de protection comprenant une structure rigide délimitant un volume de protection autour du robinet (3), le chapeau (2) comportant une paroi formant une portion centrale, s'étendant entre d'une part une extrémité inférieure (12) et, d'autre part, une extrémité supérieure (22) ouverte délimitant un orifice (5) d'accès à un volume interne abritant le robinet (3), le dispositif comprenant un cache (1) de protection du robinet (3) disposé de façon amovible sur le dispositif, caractérisé en ce que le cache (1) comprend un capuchon (6) comprenant une première face munie d'un premier relief (7) ayant une forme et des dimensions conjuguée de l'orifice (5) d'accès délimité par le chapeau (2) pour assurer le positionnement du capuchon (6) sur l'extrémité supérieure de la portion centrale avec un emboîtement du premier relief (7) dans cet orifice (5) d'accès Device for supplying fluid under pressure comprising a valve (3) connected to at least one tank (4) of gas under pressure and provided with a cap (2) for protecting the valve (3), the cap (2) comprising a rigid structure delimiting a protective volume around the valve (3), the cap (2) having a wall forming a central portion, extending between on the one hand a lower end (12) and, on the other hand, a upper end (22) opening defining an orifice (5) for access to an internal volume housing the valve (3), the device comprising a cover (1) for protecting the valve (3) removably disposed on the device, characterized in that the cover (1) comprises a cap (6) comprising a first face provided with a first relief (7) having a shape and dimensions that are conjugate with the access orifice (5) defined by the cap (2). ) to ensure the positioning of the cap (6) on the upper end of the por central ...

Pressurized fluid bottle

Bouteille de fluide sous pression, notamment de gaz sous pression, comprenant un robinet (2) abritant un circuit (5) de fluide muni d’au moins une vanne (3), la bouteille (1) comportant un dispositif indicateur de pression comprenant un piston (4) sensible à la pression dans la bouteille (1) et mobile relativement au corps du robinet (2) selon le niveau de pression dans la bouteille (1) entre au moins une première position rétractée et une seconde position déployée, le dispositif indicateur de pression comprenant en outre au moins un support (6) d'information déplaçable entre au moins deux positions ou états distincts pour symboliser respectivement au moins deux niveaux de pression selon la position du piston (4), le support (6) d'information étant mobile relativement au robinet (2) entre au moins une première position et une seconde position, le support (6) d'information étant sollicité vers sa seconde position via un organe de rappel (7), le dispositif indicateur de pression comprenant une butée (8) mobile entre une position de blocage empêchant le déplacement du support (4) d'information de sa première position vers sa seconde position et une position de déblocage permettant le déplacement du support (6) d'information de sa première position vers sa seconde position, caractérisée en ce que la butée (8) mobile est une pièce intermédiaire disposée entre le piston (4) et le support (6) d'information. Figure de l’abrégé : Fig. 1

VALVE FOR PRESSURIZED FLUID AND BOTTLE COMPRISING SUCH FAUCET

Robinet pour fluide sous pression comprenant un corps (2) abritant un circuit (3) de fluide ayant une extrémité (4) amont et une extrémité (5) aval, le circuit (3) comprenant un organe (6) de contrôle du débit dans le circuit (3), l'organe (6) de contrôle du débit étant commandé par un organe (7) d'actionnement mobile par rapport au corps (2), l'organe (7) d'actionnement étant monté mobile sur le corps (2) du robinet (1) entre une position de repos et une seconde position active, le robinet (1) comprenant au moins un organe (10, 11) fonctionnel électronique et un interrupteur (8) de commande du au moins un organe (10, 11) fonctionnel électronique, l'interrupteur (8) étant déplaçable dans au moins deux états distincts, caractérisé en ce que l'organe d'actionnement (7) est configuré pour déplacer l'interrupteur (8) d'un premier état vers un second état lors de son déplacement dans au moins une position parmi : sa position de repos, sa position active, ou une position intermédiaire entre ces deux positions Pressurized fluid valve comprising a body (2) housing a fluid circuit (3) having an upstream end (4) and a downstream end (5), the circuit (3) comprising a flow control member (6) in the circuit (3), the flow control member (6) being controlled by an actuating member (7) movable relative to the body (2), the actuating member (7) being movably mounted on the body (2) of the valve (1) between a rest position and a second active position, the valve (1) comprising at least one electronic functional member (10, 11) and a switch (8) for controlling the at least one member Electronic switch (10, 11), the switch (8) being displaceable in at least two distinct states, characterized in that the actuating member (7) is configured to move the switch (8) of a first state to a second state during its movement in at least one of: its rest position, its active position, or a posi between these two positions

VALVE FOR PRESSURIZED FLUID AND BOTTLE COMPRISING SUCH FAUCET

Robinet pour fluide sous pression comprenant un corps (2) abritant un circuit (3) de fluide ayant une extrémité (4) amont et une extrémité (5) aval, le circuit (3) comprenant un organe (6) de contrôle du débit dans le circuit (3), l'organe (6) de contrôle du débit étant commandé par un organe (7) d'actionnement mobile par rapport au corps (2), l'organe (7) d'actionnement étant monté mobile sur le corps (2) du robinet (1) entre une position de repos et une seconde position active, le robinet (1) comprenant au moins un organe (10, 11) fonctionnel électronique et un interrupteur (8) de commande du au moins un organe (10, 11) fonctionnel électronique, l'interrupteur (8) étant déplaçable dans au moins deux états distincts, caractérisé en ce que l'organe d'actionnement (7) est configuré pour déplacer l'interrupteur (8) d'un premier état vers un second état lors de son déplacement dans au moins une position parmi : sa position de repos, sa position active, ou une position intermédiaire entre ces deux positions Pressurized fluid valve comprising a body (2) housing a fluid circuit (3) having an upstream end (4) and a downstream end (5), the circuit (3) comprising a flow control member (6) in the circuit (3), the flow control member (6) being controlled by an actuating member (7) movable relative to the body (2), the actuating member (7) being movably mounted on the body (2) of the valve (1) between a rest position and a second active position, the valve (1) comprising at least one electronic functional member (10, 11) and a switch (8) for controlling the at least one member Electronic switch (10, 11), the switch (8) being displaceable in at least two distinct states, characterized in that the actuating member (7) is configured to move the switch (8) of a first state to a second state during its movement in at least one of: its rest position, its active position, or a posi between these two positions

Fluid bottle valve (s) and fluid bottle comprising such a valve.

Robinet de bouteille(s) de fluide sous pression comprenant un corps (2) s’étendant selon un direction longitudinale (A) et sur lequel est monté un accessoire (3) tel qu’un indicateur de pression, ledit accessoire (3) étant rendu solidaire du corps (2) du robinet au moyen d’un système (5, 6, 7) d’accrochage élastique autorisant un débattement limité de l’accessoire (3) par rapport au corps (2) du robinet, caractérisé en ce que le système (4, 5, 6, 7) d’accrochage comprend deux rainures (7) formées sur deux faces latérales opposées du corps (2) et deux pattes (4) d’accrochage flexibles solidaires de l’accessoire (3) dont les extrémités sont reçues respectivement dans les deux rainures (7), le système (4, 5, 6, 7) d’accrochage comprenant en outre une bride (5) de serrage vissées sur l’accessoire (3) et générant un effort sur les pattes (4) dans le sens de leur maintien dans lesdites rainures (7) respectives Figure de l’abrégé : Fig. 2 Pressurized fluid bottle valve (s) comprising a body (2) extending in a longitudinal direction (A) and on which is mounted an accessory (3) such as a pressure indicator, said accessory (3) being made integral with the body (2) of the valve by means of an elastic coupling system (5, 6, 7) allowing limited movement of the accessory (3) relative to the body (2) of the valve, characterized in that that the attachment system (4, 5, 6, 7) comprises two grooves (7) formed on two opposite side faces of the body (2) and two flexible attachment tabs (4) integral with the accessory (3) the ends of which are respectively received in the two grooves (7), the hooking system (4, 5, 6, 7) further comprising a clamping flange (5) screwed onto the accessory (3) and generating a force on the tabs (4) in the direction of their retention in said respective grooves (7) Figure of the abstract: FIG. 2

Pressurized fluid supply device and pressurized fluid storage assembly (s) comprising such a device

Dispositif de fourniture de fluide sous pression, notamment de gaz sous pression, comprenant un premier robinet (3) abritant un circuit (13) interne de fluide, le dispositif (1) comportant un second robinet (5) comprenant un circuit (15) interne, le second robinet (5) formant une entité physique distincte du premier robinet (3), le premier (3) robinet et le second (5) robinet comprenant des organes (6, 7) d'accrochages respectifs formant un système de connexion rapide mâle/femelle amovible du second robinet (5) sur le premier (3) robinet, les circuits (13, 15) internes comprenant un ensemble de vanne(s) (4, 9) pour autoriser ou empêcher la circulation du fluide vers une sortie (25) du dispositif lorsque le second robinet (5) est accroché sur le premier robinet (3) via le système de connexion rapide, le dispositif (1) comprenant au moins un organe (11) de commande mobile actionnable manuellement pour commander l’ensemble de vanne(s), l’organe (11) de commande étant mobile entre une première position de repos dans laquelle la circulation de fluide vers la sortie (25) est empêchée et une seconde position active dans laquelle la circulation de fluide vers la sortie (25) est autorisée, le système de connexion rapide comprenant une pièce (14) de connexion du second robinet (5) sur le premier (3) robinet, la pièce (14) de connexion étant mobile entre une première position lorsque la connexion rapide n’est pas établie entre le second robinet (5) et le premier (3) robinet et une seconde position lorsque la connexion rapide est établie entre le second robinet (5) et le premier robinet (3), caractérisé en ce que, dans sa première position, la pièce (14) de connexion assure un blocage de l’organe (11) de commande dans sa première position de repos pour empêcher son déplacement vers sa seconde position active et en ce que, dans sa seconde position, la pièce (14) de connexion ne bloque pas l’organe (11) de commande dans sa première position de repos pour autoriser son dé ...

Valve for pressurized fluid

DEVICE FOR SUPPLYING FLUID WITH PRESSURE AND UNIT INCLUDING SUCH A DEVICE FOR STORING FLUID WITH PRESSURE

TAPE FOR FLUID UNDER PRESSURE, AND BOTTLE INCLUDING SUCH A TAP

PRESSURE FLUID VALVE

Device and method for filling pressurized gas tanks

Dispositif de remplissage de réservoirs de gaz sous pression, en particulier de réservoirs d’hydrogène de véhicules, comprenant un circuit de transfert de fluide ayant une extrémité amont raccordée à une pluralité de sources (2 à 10) de fluide sous pression et une extrémité aval comprenant au moins une terminaison (11, 12, 13) de distribution destinée à être raccordée à un réservoir à remplir, les sources (2 à 10) étant reliées en parallèle à la au moins une terminaison (11, 12, 13), chaque source (2 à 10) comprenant une sortie de fluide raccordée à une vanne de sortie (22 à 30) respective, les sources (2 à 10) étant raccordées en parallèle en sous-groupes distincts à des lignes de transfert (35 à 37) respectives, c’est-à-dire que toutes les sources d’un même sous-groupe sont raccordées en parallèle à une ligne de transfert (35 à 37) dédiée, plusieurs sous-groupe et de préférence tous les sous-groupes de sources étant composés chacun de plusieurs sources, les lignes de transfert (35 à 37) étant raccordées en parallèle à la au moins une terminaison (11, 12, 13) de distribution et comprenant chacune une vanne de transfert (32 à 34) respective, la au moins une terminaison (11, 12, 13) de distribution comprenant un ensemble de vanne (s) de contrôle, la au moins une terminaison (11, 12, 13) de distribution et son ensemble de vanne (s) de contrôle étant dimensionnés pour transférer un débit de gaz de remplissage maximal déterminé, les vannes de sortie (22 à 30), les lignes de transfert (35 à 37) et les vannes de transfert (32 à 34) étant dimensionnées pour transférer un débit de gaz de transfert maximal qui est inférieur au débit de gaz de remplissage maximal, la somme de plusieurs débits de gaz de transfert maximauxs fournis par plusieurs vannes de sortie (22 à 30) et plusieurs lignes de transfert (35 à 37) étant supérieure ou égal au débit de gaz de remplissage maximal. Figure de l’abrégé : Fig. 1 Device for filling pressurized gas tanks, in particular hydrogen tanks of ...

Device and method for filling pressurised gas tanks

The invention relates to a device for filling pressurised gas tanks, in particular hydrogen tanks of vehicles, comprising a fluid transfer circuit having an upstream end connected to a plurality of sources (2 to 10) of pressurised fluid and a downstream end comprising at least one distribution termination (11, 12, 13) for connection to a tank to be filled, the sources (2 to 10) being connected in parallel to the at least one termination (11, 12, 13), each source (2 to 10) comprising a fluid outlet connected to a respective outlet valve (22 to 30), the sources (2 to 10) being connected in parallel in distinct subgroups to respective transfer lines (35 to 37), i.e. all the sources of a single subgroup are connected in parallel to a dedicated transfer line (35 to 37), each of several subgroups of sources, preferably all the subgroups, comprising multiple sources, the transfer lines (35 to 37) being connected in parallel to the at least one distribution termination (11, 12, 13) and each comprising a respective transfer valve (32 to 34), the at least one distribution termination (11, 12, 13) comprising a set of control valves (32 to 34), the at least one distribution termination (11, 12, 13) and its set of control valves (32 to 34) being sized to transfer a predetermined maximum filling gas flow rate, the outlet valves (22-30), the transfer lines (35-37) and the transfer valves (32-34) being sized to transfer a maximum transfer gas flow rate that is less than the maximum filling gas flow rate, the sum of a plurality of maximum transfer gas flow rates provided by a plurality of outlet valves (22-30) and a plurality of transfer lines (35-37) being greater than or equal to the maximum filling gas flow rate.

Valve for bottle(s) of fluid and bottle of fluid comprising such a valve

Robinet de bouteille(s) de fluide sous pression comprenant un corps (2) s'étendant selon un direction longitudinale (A) et sur lequel est monté un accessoire (3) tel qu'un indicateur de pression, ledit accessoire (3) étant rendu solidaire du corps (2) du robinet au moyen d'un système (5, 6, 7) d'accrochage élastique autorisant un débattement limité de l'accessoire (3) par rapport au corps (2) du robinet, caractérisé en ce que le système (4, 5, 6, 7) d'accrochage comprend deux rainures (7) formées sur deux faces latérales opposées du corps (2) et deux pattes (4) d'accrochage flexibles solidaires de l'accessoire (3) dont les extrémités sont reçues respectivement dans les deux rainures (7), le système (4, 5, 6, 7) d'accrochage comprenant en outre une bride (5) de serrage vissées sur l'accessoire (3) et générant un effort sur les pattes (4) dans le sens de leur maintien dans lesdites rainures (7) respectives

Device for supplying fluid under pressure and assembly for storing pressurised fluid including such a device

Design for a coat

Connector for pressurised fluid, valve and container comprising such a connector and connection method

Raccord de fluide sous pression, notamment pour un stockage de gaz sous pression, le raccord (1) étant destiné à coopérer avec un appareil de remplissage et/ou de soutirage de fluide sous pression, le raccord (1) comprenant un corps (2) délimitant un circuit (3) interne de soutirage et éventuellement de remplissage de fluide, ledit circuit (3) s'étendant entre une extrémité amont (5) destinée à être mise en relation avec un volume de stockage de fluide sous pression et une extrémité aval (6) destinée à être reliée avec un appareil de soutirage et/ou de remplissage de fluide sous pression, le raccord (1) comprenant, au niveau de l'extrémité (6) aval du circuit (3), un clapet (8) pare-poussière mobile relativement au corps (2) entre une position de fermeture de l'extrémité (6) aval du circuit (3) et au moins une position d'ouverture, caractérisé en ce que le clapet (8) pare-poussière est un clapet de pression résiduelle configuré, lorsqu'il est en position fermée, pour maintenir une pression minimale déterminée dans le circuit (3) et permettant une évacuation de gaz vers l'extérieur en cas de surpression dans le circuit (3) au-dessus d'un seuil de pression déterminé par rapport à l'extérieur. Pressurized fluid connection, in particular for storing pressurized gas, the connection (1) being intended to cooperate with an apparatus for filling and / or withdrawing pressurized fluid, the connection (1) comprising a body (2) delimiting an internal circuit (3) for withdrawing and possibly filling fluid, said circuit (3) extending between an upstream end (5) intended to be placed in connection with a pressurized fluid storage volume and a downstream end (6) intended to be connected with a device for withdrawing and / or filling pressurized fluid, the connection (1) comprising, at the level of the downstream end (6) of the circuit (3), a valve (8) dust cover movable relative to the body (2) between a closed position of the downstream end (6) of ...

Trim part for a motor vehicle

Die Erfindung betrifft ein Verkleidungsteil für ein Kraftfahrzeug, umfassend einen Verkleidungsgrundkörper (1) mit einer bei bestimmungsgemäßer Verwendung sichtbaren Außenseite (A), und umfassend eine Tragstruktur (2) die zum größten Teil auf der der Außenseite (A) gegenüberliegenden Rückseite (R) des Verkleidungsgrundkörpers (1) angeordnet ist, wobei der Verkleidungsgrundkörper (1) und die Tragstruktur (2) über ihre jeweiligen Randbereiche (3, 3') miteinander verbunden sind, wobei der Randbereich (3) des Verkleidungsgrundkörpers (1) eine federnde Lasche (4) bildet, die von der Außenseite (A) weg in Richtung zu der Tragstruktur (2) ausgebildet ist, und der Randbereich (3') der Tragstruktur (2) eine schlitzförmige Aufnahme (5) zum Aufnehmen der Lasche (4) aufweist, wobei die Aufnahme (5) durch einen Klemmschenkel (6) und eine dem Klemmschenkel (6) gegenüberliegende Abstützung (7) gebildet ist, wobei im verbundenen Zustand die Lasche (4) aufgrund ihrer federnden Eigenschaften mit einer Klemmkraft an der Abstützung (7) anliegt. The invention relates to a cladding part for a motor vehicle, comprising a basic cladding body (1) with an outside (A) that is visible when used as intended, and comprising a support structure (2) which is mostly on the rear side (R) of the outside (A) opposite Cladding base body (1) is arranged, the cladding base body (1) and the supporting structure (2) being connected to one another via their respective edge areas (3, 3 '), the edge area (3) of the cladding base body (1) having a resilient tab (4) forms, which is formed from the outside (A) away in the direction of the support structure (2), and the edge region (3 ') of the support structure (2) has a slot-shaped receptacle (5) for receiving the tab (4), the The receptacle (5) is formed by a clamping leg (6) and a support (7) opposite the clamping leg (6) locking force is applied to the support (7).

Pressurized fluid bottle

Bouteille de fluide sous pression, notamment de gaz sous pression, comprenant un robinet (2) abritant un circuit (5) de fluide muni d’au moins une vanne (3), la bouteille (1) comportant un dispositif indicateur de pression comprenant un piston (4) sensible à la pression dans la bouteille (1) et mobile relativement au corps du robinet (2) selon le niveau de pression dans la bouteille (1) entre au moins une première position rétractée et une seconde position déployée, le dispositif indicateur de pression comprenant en outre au moins un support (6) d'information déplaçable entre au moins deux positions ou états distincts pour symboliser respectivement au moins deux niveaux de pression selon la position du piston (4), le support (6) d'information étant mobile relativement au robinet (2) entre au moins une première position et une seconde position, le support (6) d'information étant sollicité vers sa seconde position via un organe de rappel (7), le dispositif indicateur de pression comprenant une butée (8) mobile entre une position de blocage empêchant le déplacement du support (4) d'information de sa première position vers sa seconde position et une position de déblocage permettant le déplacement du support (6) d'information de sa première position vers sa seconde position, caractérisée en ce que la butée (8) mobile est une pièce intermédiaire disposée entre le piston (4) et le support (6) d'information. Figure de l’abrégé : Fig. 1 Bottle of pressurized fluid, in particular of pressurized gas, comprising a valve (2) housing a fluid circuit (5) provided with at least one valve (3), the bottle (1) comprising a pressure indicator device comprising a piston (4) sensitive to the pressure in the bottle (1) and movable relative to the valve body (2) according to the pressure level in the bottle (1) between at least a first retracted position and a second deployed position, the device pressure indicator further comprising at least one information support ...

Valve for pressurised fluid

Robinet pour fluide sous pression, avec ou sans détendeur de pression intégré, comprenant un corps (2) abritant un circuit (3) de fluide ayant une extrémité (4) amont destinée à être mise en relation avec une réserve de fluide sous pression et une extrémité (5) aval destinée à être mise en relation avec un appareil récepteur, le circuit (3) de fluide comprenant un organe (6) de contrôle du débit dans le circuit (3) de fluide, l'organe (6) de contrôle du débit étant commandé par un organe (7) d'actionnement mobile par rapport au corps (2) du robinet (1), le robinet (1) comprenant au moins un organe (10) fonctionnel électronique disposé dans un boîtier (8) clos situé sur le corps (2), caractérisé en ce que le boîtier (8) comprend une paroi périphérique en communication avec l'extérieur du robinet (2), ladite paroi (18) périphérique comprenant au moins un orifice (9) d'évent refermé par un couvercle (11) fixé sur ladite paroi périphérique Pressurized fluid valve, with or without built-in pressure reducer, comprising a body (2) housing a fluid circuit (3) having an upstream end (4) for connection with a pressurized fluid reservoir and a downstream end (5) intended to be connected to a receiving apparatus, the fluid circuit (3) comprising a flow control member (6) in the fluid circuit (3), the control member (6) the flow being controlled by an actuating member (7) movable relative to the body (2) of the valve (1), the valve (1) comprising at least one electronic functional member (10) arranged in a closed housing (8) located on the body (2), characterized in that the housing (8) comprises a peripheral wall in communication with the outside of the valve (2), said peripheral wall (18) comprising at least one vent orifice (9) closed by a cover (11) fixed on said peripheral wall

Device for delivering pressurised fluid and set of storage unit(s) for pressurised fluid including such a device

Dispositif de fourniture de fluide sous pression, notamment de gaz sous pression, comprenant un premier robinet (3) abritant un circuit (13) interne de fluide, le dispositif (1) comportant un second robinet (5) comprenant un circuit (15) interne, le second robinet (5) formant une entité physique distincte du premier robinet (3), le premier (3) robinet et le second (5) robinet comprenant des organes (6, 7) d'accrochages respectifs formant un système de connexion rapide male/femelle amovible du second robinet (5) sur le premier (3) robinet, les circuits (13, 15) internes comprenant un ensemble de vanne(s) (4, 9) pour autoriser ou empêcher la circulation du fluide vers une sortie (25) du dispositif lorsque le second robinet (5) est accroché sur le premier robinet (3) via le système de connexion rapide, le dispositif (1) comprenant au moins un organe (11) de commande mobile actionnable manuellement pour commander l'ensemble de vanne(s), l'organe (11) de commande étant mobile entre une première position de repos dans laquelle la circulation de fluide vers la sortie (25) est empêchée et une seconde position active dans laquelle la circulation de fluide vers la sortie (25) est autorisée, le système de connexion rapide comprenant un organe (14) de verrouillage/déverrouillage du second robinet (5) sur le premier (3) robinet, l'organe (14) de verrouillage/déverrouillage étant mobile entre une première position de déverrouillage lorsque la connexion rapide n'est pas établie entre le second robinet (5) et le premier (3) robinet ou permettant la séparation entre le second robinet (5) et le premier (3) robinet lorsque la connexion rapide est établie entre le second robinet (5) et le premier (3) robinet, et une seconde position de verrouillage empêchant la séparation entre le second robinet (5) et le premier (3) robinet lorsque la connexion rapide est établie entre ces derniers, caractérisé en ce que, dans sa seconde position active l'organe (11) de ...

Device and method for filling pressurised gas tanks

The invention relates to a device for filling pressurised gas tanks, in particular hydrogen tanks of vehicles, comprising a fluid transfer circuit having an upstream end connected to a plurality of sources (2 to 10) of pressurised fluid and a downstream end comprising at least one distribution termination (11, 12, 13) for connection to a tank to be filled, the sources (2 to 10) being connected in parallel to the at least one termination (11, 12, 13), each source (2 to 10) comprising a fluid outlet connected to a respective outlet valve (22 to 30), the sources (2 to 10) being connected in parallel in distinct subgroups to respective transfer lines (35 to 37), i.e. all the sources of a single subgroup are connected in parallel to a dedicated transfer line (35 to 37), each of several subgroups of sources, preferably all the subgroups, comprising multiple sources, the transfer lines (35 to 37) being connected in parallel to the at least one distribution termination (11, 12, 13) and each comprising a respective transfer valve (32 to 34), the at least one distribution termination (11, 12, 13) comprising a set of control valves (32 to 34), the at least one distribution termination (11, 12, 13) and its set of control valves (32 to 34) being sized to transfer a predetermined maximum filling gas flow rate, the outlet valves (22-30), the transfer lines (35-37) and the transfer valves (32-34) being sized to transfer a maximum transfer gas flow rate that is less than the maximum filling gas flow rate, the sum of a plurality of maximum transfer gas flow rates provided by a plurality of outlet valves (22-30) and a plurality of transfer lines (35-37) being greater than or equal to the maximum filling gas flow rate.

Design for a coat

Cylinder for pressurised fluid

Bouteille de fluide sous pression, notamment de gaz sous pression, comprenant un robinet (2) abritant un circuit (5) de fluide muni d'au moins une vanne (3), la bouteille (1) comportant un dispositif indicateur de pression comprenant un piston (4) sensible à la pression dans la bouteille (1) et mobile relativement au corps du robinet (2) selon le niveau de pression dans la bouteille (1) entre au moins une première position rétractée et une seconde position déployée, le dispositif indicateur de pression comprenant en outre au moins un support (6) d'information déplaçable entre au moins deux positions ou états distincts pour symboliser respectivement au moins deux niveaux de pression selon la position du piston (4), le support (6) d'information étant mobile relativement au robinet (2) entre au moins une première position et une seconde position, le support (6) d'information étant sollicité vers sa seconde position via un organe de rappel (7), le dispositif indicateur de pression comprenant une butée (8) mobile entre une position de blocage empêchant le déplacement du support (4) d'information de sa première position vers sa seconde position et une position de déblocage permettant le déplacement du support (6) d'information de sa première position vers sa seconde position, caractérisée en ce que la butée (8) mobile est une pièce intermédiaire disposée entre le piston (4) et le support (6) d'information. Bottle of pressurized fluid, in particular of pressurized gas, comprising a valve (2) housing a fluid circuit (5) provided with at least one valve (3), the bottle (1) comprising a pressure indicator device comprising a piston (4) sensitive to the pressure in the bottle (1) and movable relative to the valve body (2) according to the pressure level in the bottle (1) between at least a first retracted position and a second deployed position, the device pressure indicator further comprising at least one information support (6) movable between at ...

Device and method for filling pressurized gas tanks

Dispositif de remplissage de réservoirs de gaz sous pression, en particulier de réservoirs d’hydrogène de véhicules, comprenant un circuit de transfert de fluide ayant une extrémité amont raccordée à une pluralité de sources (2 à 10) de fluide sous pression et une extrémité aval comprenant au moins une terminaison (11, 12, 13) de distribution destinée à être raccordée à un réservoir à remplir, les sources (2 à 10) étant reliées en parallèle à la au moins une terminaison (11, 12, 13), chaque source (2 à 10) comprenant une sortie de fluide raccordée à une vanne de sortie (22 à 30) respective, les sources (2 à 10) étant raccordées en parallèle en sous-groupes distincts à des lignes de transfert (35 à 37) respectives, c’est-à-dire que toutes les sources d’un même sous-groupe sont raccordées en parallèle à une ligne de transfert (35 à 37) dédiée, plusieurs sous-groupe et de préférence tous les sous-groupes de sources étant composés chacun de plusieurs sources, les lignes de transfert (35 à 37) étant raccordées en parallèle à la au moins une terminaison (11, 12, 13) de distribution et comprenant chacune une vanne de transfert (32 à 34) respective, la au moins une terminaison (11, 12, 13) de distribution comprenant un ensemble de vanne (s) de contrôle, la au moins une terminaison (11, 12, 13) de distribution et son ensemble de vanne (s) de contrôle étant dimensionnés pour transférer un débit de gaz de remplissage maximal déterminé, les vannes de sortie (22 à 30), les lignes de transfert (35 à 37) et les vannes de transfert (32 à 34) étant dimensionnées pour transférer un débit de gaz de transfert maximal qui est inférieur au débit de gaz de remplissage maximal, la somme de plusieurs débits de gaz de transfert maximauxs fournis par plusieurs vannes de sortie (22 à 30) et plusieurs lignes de transfert (35 à 37) étant supérieure ou égal au débit de gaz de remplissage maximal. Figure de l’abrégé : Fig. 1 Device for filling pressurized gas tanks, in particular vehicle hydrogen ...

Providing social endorsements with online advertising

Third-party publishers (such as websites) provide online advertisements combined with social endorsement information to users. A request for an advertisement is received from a viewing user via a third-party publisher system. A particular advertisement is selected in response to this request, and one or more advertisement tags associated with the advertisement are retrieved. The advertisement tags comprise information related to the advertisement. Social networking system data for users related to the viewing user is retrieved. Social endorsement information is obtained using the social networking system data and the advertisement tags associated with the advertisement. The social endorsement information and the advertisement are then combined and transmitted to the third-party publisher system, or are transmitted individually for combination by the third-party publisher system.

Treatment device for extracorporeal immunotolerance-enhancing blood treatment

Eine Behandlungsvorrichtung (100), die zur extrakorporalen Blutbehandlung von Blut eines Probanden (2) für eine Immuntoleranz-Steigerung des Probanden (2) eingerichtet ist, umfasst mindestens einen Behälter (10), der einen Innenraum (11) zur Aufnahme einer Blutprobe (1) vom Blut des Probanden (2) und eine Austauscheinrichtung (20) aufweist, die zur Zuleitung und/oder Ableitung der Blutprobe (1) in oder aus dem Innenraum (11) des Behälters (10) eingerichtet ist, und eine Zellexpositionseinrichtung (30), die im Behälter (10) positioniert ist und biologisches Zellmaterial (31) mit Oberflächenmolekülen aufweist, das für eine stoffliche Wechselwirkung mit der Blutprobe (1), umfassend eine Reaktion von körpereigenen Immunzellen im Blut mit den Oberflächenmolekülendes Zellmaterials, im Innenraum (11) des Behälters (10) angeordnet ist. Es werden auch ein Kit zur extrakorporalen Blutbehandlung und Verfahren zum Betreiben der Behandlungsvorrichtung beschrieben.

Dispositif de fourniture de fluide sous pression et bouteille(s) de fluide sous pression comprenant un tel dispositif

Proteins binding nkg2d, cd16 and baff-r

Multispecific binding proteins that bind NKG2D receptor, CD 16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Proteínas que se unen a nkg2d, cd16 y baff-r

Se describen proteínas de unión multiespecíficas que se unen al receptor NKG2D, a CD16 y al receptor del factor activador del linfocito B (BAFF-R), así como composiciones farmacéuticas y métodos terapéuticos de las proteínas de unión multiespecíficas útiles para el tratamiento del cáncer y de enfermedades inflamatorias autoinmunitarias. Reivindicación 60: Una célula que comprende uno o más ácidos nucleicos que codifican una proteína de acuerdo con una cualquiera de las reivindicaciones 1 a 58.

Combining machine learning with domain knowledge and first principles for modeling in the process industries

Computer-based process modeling and simulation methods and systems combine first principles models and machine learning models to benefit where either model is lacking. In one example, input values (measurements) are adjusted by first principles techniques. A machine learning model of the chemical process of interest is trained on the adjusted values. In another example, a machine learning model represents the residual (delta) between a first principles model prediction and empirical data. Residual machine learning models correct physical phenomena predictions in a first principles model of the chemical process. In another example, a first principles simulation model uses the process input data and predictions of the machine learning model to generate simulated results of the chemical process. The hybrid models enable a process engineer to troubleshoot the chemical process, enable debottlenecking the chemical process, enable optimizing performance of the chemical process at the subject industrial plant, and enable automated process control.

Method for producing three-dimensional hydrogel structures and device for the layerwise building-up of such hydrogel structures

Combining machine learning with domain knowledge and first principles for modeling in the process industries

Computer-based process modeling and simulation methods and systems combine first principles models and machine learning models to benefit where either model is lacking. In one example, input values (measurements) are adjusted by first principles techniques. A machine learning model of the chemical process of interest is trained on the adjusted values. In another example, a machine learning model represents the residual (delta) between a first principles model prediction and empirical data. Residual machine learning models correct physical phenomena predictions in a first principles model of the chemical process. In another example, a first principles simulation model uses the process input data and predictions of the machine learning model to generate simulated results of the chemical process. The hybrid models enable a process engineer to troubleshoot the chemical process, enable debottlenecking the chemical process, enable optimizing performance of the chemical process at the subject industrial plant, and enable automated process control.

Antibodies targeting baff-r and use thereof

Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

Anticuerpos dirigidos a baff-r y uso de estos

Se divulgan proteínas con dominios variables de cadena ligera y cadena pesada de anticuerpos que se pueden aparear para formar un sitio de unión a antígeno dirigido a BAFF-R en una célula, composiciones farmacéuticas que comprenden tales proteínas y métodos terapéuticos que utilizan tales proteínas y composiciones farmacéuticas, que incluyen para el tratamiento del cáncer o una enfermedad autoinmunitaria. Reivindicación 32: Un conjugado de anticuerpo-fármaco que comprende la proteína de cualquiera de las reivindicaciones 22 - 31 y un resto de fármaco. Reivindicación 34: Una inmunocitocina que comprende el sitio de unión a antígeno de cualquiera de las reivindicaciones 1 - 21 y una citocina. Reivindicación 42: Un ácido nucleico aislado que codifica el CAR de cualquiera de las reivindicaciones 37 - 41. Reivindicación 43: Un vector de expresión que comprende el ácido nucleico aislado de la reivindicación 42. Reivindicación 47: La célula efectora inmunitaria de la reivindicación 46, en donde el linfocito T es un linfocito T CD8⁺, un linfocito T CD4⁺, un linfocito T gd o una célula NKT.

Dispositif de distribution de fluide

L’invention concerne un dispositif de distribution de fluide (1) comprenant un corps (2) abritant une première (3) et une seconde (4) extrémité, ledit corps (2) comprenant un premier circuit interne de fluide (21) s’étendant entre les deux extrémités (3)(4), ledit premier circuit interne de fluide (21) comprenant une première vanne (5) mobile, le corps de ladite première vanne (5) comprenant un deuxième circuit de fluide (22) s’étendant entre les deux extrémités (3)(4) et comprenant une vanne mobile de fermeture (8) et une vanne de régulation (9) positionnée au travers d’une chambre (6) définie par ladite première vanne (5) et une première enveloppe (7), ledit dispositif de distribution de fluide (1) comprenant un ensemble de joint d'étanchéité comprenant un premier joint (10) entre ledit corps (2) et ladite première vanne (5) et un deuxième joint (11) entre ladite première vanne (5) et la première enveloppe (7). Figure d’abrégé : Fig. 1

Method for producing three-dimensional hydrogel structures and device for the layerwise building-up of such hydrogel structures

The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure. The invention relates further also to a device for the layerwise building-up of three-dimensional hydrogel structures.

Method for producing three-dimensional hydrogel structures and device for the layerwise building-up of such hydrogel structures

The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure. The invention relates further also to a device for the layerwise building-up of three-dimensional hydrogel structures.

Proteins binding nkg2d, cd16 and baff-r

Multispecific binding proteins that bind NKG2D receptor, CD 16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Autonomous Industrial Truck

Transporting loads is a fundamental component of intralogistics. Autonomous industrial trucks can be used for this. The autonomous industrial truck claimed according to the invention is able, by means of the implemented navigation, load receiving and load placing methods, to ensure efficient transporting of loads. The invention relates to an autonomous industrial truck having a rearwardly-directed sensor unit for detecting the load and the loading environment and implemented process sequences for approaching the load, receiving the load and placing the load.

Autonomes flurförderzeug

Der Transport von Lasten ist ein elementarer Bestandteil der Intralogistik. Hierbei können autonome Flurförderzeuge eingesetzt werden. Das beanspruchte, autonome Flurförderzeug ist mittels der implementierten Navigations-, Lastaufnahme- und Lastabsetzverfahren in der Lage, einen effizienten Lastentransport zu gewährleisten. Beansprucht wird ein autonomes Flurförderzeug mit einer rückwärtsgerichteten Sensoreinheit zur Erfassung der Ladung und des Ladungsumfelds sowie implementierten Verfahrensabläufen zum Heranfahren an die Ladung, Aufnehmen der Ladung und Absetzen der Ladung.

Dispositif de fourniture de fluide sous pression et bouteille(s) de fluide sous pression comprenant un tel dispositif

Antibodies targeting baff-r and use thereof

Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

Urządzenie do dostarczania płynu pod ciśnieniem i butelka(-i) do płynu pod ciśnieniem zawierająca to urządzenie

Proteins binding nkg2d, cd16 and baff-r

Multispecific binding proteins that bind NKG2D receptor, CD 16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Proteins binding nkg2d, cd16 and baff-r

Design for a coat

Autonomes flurförderzeug

Ein Verfahren zur Kalibrierung eines Inertialsensors (40) einer mobilen Basis (1) ist offenbart, wobei die mobile Basis (1) mindestens einen Sensor (15, 16, 18, 20, 29, 31, 32) zur Erfassung eines Umfelds der mobilen Basis (1) umfasst. Das Verfahren umfasst eine Erfassung des Umfelds der mobilen Basis (1) mittels des mindestens einen Sensors (15, 16, 18, 20, 29, 31, 32); eine Detektion, basierend auf der Erfassung des Umfelds, eines Hindernisses (151); eine Ermittlung, basierend auf der Erfassung des Umfelds, eines Erfassungswinkels des Hindernisses (151); eine Durchführung mindestens einer Drehung der mobilen Basis (1) um einen Drehwinkel, wobei eine Ermittlung des Drehwinkels durch eine Auswertung des Erfassungswinkels erfolgt; und einen Vergleich des basierend auf der Auswertung des Erfassungswinkels ermittelten Drehwinkels mit einem mittels des Inertialsensors (40) ermittelten Drehwinkel.

Verfahren zur herstellung von vaskularisiertem biologischem gewebe

Ein Verfahren zur Herstellung von vaskularisiertem biologischen Gewebe, umfasst die Schritte Herstellung einer Netzwerkstruktur aus einer Vielzahl von miteinander verbundenen Filamenten (11) eines Stützpolymers, Beschichtung der Netzwerkstruktur mit einem Proteinmaterial, Besiedlung der beschichteten Netzwerkstruktur mit Endothelzellen (2, 2A) und mit Gewebe-bildenden biologischen Zellen (3), und Auflösung der Filamente (11), so dass das vaskularisierte Gewebe (1) gebildet wird. Das vaskularisierte Gewebe (1) umfasst z. B. Herzmuskelzellen, Leberzellen, Nierenzellen, Nervenzellen und/oder Pankreaszellen.

Method for producing three-dimensional hydrogel structures and device for the layerwise building-up of such hydrogel structures

Antibodies targeting baff-r and use thereof

Układ do przewodzenia, obróbki i/lub pomiaru płynu

Dispositif de distribution de fluide

L'invention concerne un dispositif de distribution de fluide (1) comprenant un corps (2) abritant une première (3) et une seconde (4) extrémité, ledit corps (2) comprenant un premier circuit interne de fluide (21) s'étendant entre les deux extrémités (3)(4), ledit premier circuit interne de fluide (21) comprenant une première vanne (5) mobile, le corps de ladite première vanne (5) comprenant un deuxième circuit de fluide (22) s'étendant entre les deux extrémités (3)(4) et comprenant une vanne mobile de fermeture (8) et une vanne de régulation (9) positionnée au travers d'une chambre (6) définie par ladite première vanne (5) et une première enveloppe (7), ledit dispositif de distribution de fluide (1) comprenant un ensemble de joint d'étanchéité comprenant un premier joint (10) entre ledit corps (2) et ladite première vanne (5) et un deuxième joint (11) entre ladite première vanne (5) et la première enveloppe (7).

Design fob a coat

Autonomes flurförderzeug

Ein Verfahren zur Kalibrierung eines Inertialsensors (40) einer mobilen Basis (1) ist offenbart, wobei die mobile Basis (1) mindestens einen Sensor (15, 16, 18, 20, 29, 31, 32) zur Erfassung eines Umfelds der mobilen Basis (1) umfasst. Das Verfahren umfasst eine Erfassung des Umfelds der mobilen Basis (1) mittels des mindestens einen Sensors (15, 16, 18, 20, 29, 31, 32); eine Detektion, basierend auf der Erfassung des Umfelds, eines Hindernisses (151); eine Ermittlung, basierend auf der Erfassung des Umfelds, eines Erfassungswinkels des Hindernisses (151); eine Durchführung mindestens einer Drehung der mobilen Basis (1) um einen Drehwinkel, wobei eine Ermittlung des Drehwinkels durch eine Auswertung des Erfassungswinkels erfolgt; und einen Vergleich des basierend auf der Auswertung des Erfassungswinkels ermittelten Drehwinkels mit einem mittels des Inertialsensors (40) ermittelten Drehwinkel.

Autonomes flurförderzeug

Ein Computer-implementiertes Verfahren zur Steuerung eines autonomen Flurförderzeug (5), umfasst eine Erfassung des Umfelds des autonomen Flurförderzeugs (5) und eine Erfassung und Auswertung von Mustern; wobei die Muster eine Erkennung einer Markierung (202), einer Schiene (201), von Identifikationsvorrichtungen (z.B. 203) oder einer Ladung (143) beinhalten.

Anordnung zur leitung, behandlung und/oder messung eines fluids

Anordnung (1) zum Einbau in eine Rohrleitung eines Fluidnetzes, umfassend ein Anschlussgehäuse (2), mit einem Zulauf (3), einem Ablauf (4), und einer Anschlussöffnung (5) zum Anschließen einer austauschbaren Funktionseinheit (10), wobei das Anschlussgehäuse (2) ein drehbar angeordnetes Kernstück (6) aufweist, durch dessen Drehung der Durchfluss des Fluids durch das Anschlussgehäuse (2) sperrbar und/oder freigebbar ist, das Kernstück (6) eine Aufnahme (7) zum Anschließen der Funktionseinheit (10) aufweist, und die Aufnahme (7) sowie die Anschlussöffnung (5) in gleicher Richtung orientiert sind.

Anordning til at lede, behandle og/eller måle et fluid

Anordnung zur leitung, behandlung und/oder messung eines fluids

Dispositivo de suministro de fluido presurizado y cilindro o cilindros de fluido presurizado que comprenden dicho dispositivo

Dispositivo para suministrar fluido a presión, en particular gas a presión, que comprende una primera válvula (3) que aloja un circuito interno de fluido (13), comprendiendo el dispositivo (1) una segunda válvula (5) que comprende un circuito interno (15) y que forma una entidad física distinta del primer grifo (3), el primer (3) grifo y el segundo (5) grifo que comprende respectivos miembros de enganche (6, 7) que forman un sistema de conexión rápida macho/hembra extraíble del segundo grifo (5) en el primer (3) grifo, estando configurados los dos grifos (3, 5) para poner en comunicación sus circuitos internos (13, 15) cuando el segundo grifo (5) se engancha al primer grifo (3) a través de la conexión rápida. sistema, comprendiendo los circuitos internos (13, 15) un conjunto de válvula(s) (4, 9) para controlar la circulación del fluido hacia una salida (25), comprendiendo el dispositivo (1) al menos un miembro de control móvil (11, 14) operable manualmente para controlar el conjunto de válvula(s) y/o el sistema de conexión rápida, comprendiendo el dispositivo un miembro (8) para purgar al menos uno de los circuitos (13, 15) internos, el miembro de purga (8) estar en comunicación por un lado con el o los circuitos internos (13, 15) y, por otro lado, con una zona de descarga externa tal como la atmósfera, siendo el miembro de purga (8) móvil entre un estado cerrado impidiendo la purga del(los) circuito(s) interno(s) (13, 15) hacia la zona de descarga y un estado abierto que permite la purga del(los) circuito(s) interno(s) (13) hacia la zona de descarga, caracterizado porque el miembro de purga (8) puede ser accionado en su estado abierto por al menos un miembro de control (11, 14). (Traducción automática con Google Translate, sin valor legal)

Selektives freisetzungssystem für tumortherapeutika und tumordiagnostika sowie biosensor für tumorgewebe

Die vorliegende Erfindung betrifft allgemein einen Sensor für Tumorgewebe und ein lokales Freisetzungssystem von Therapeutika/Diagnostika zur zielgerichteten Tumortherapie und Tumordiagnostik. Konkreter betrifft die Erfindung ein kationen-stabilisiertes Biopolymer-Gel, insbesondere ein Alginat-Gel, zur Verwendung als Trägermatrix für ein Tumortherapeutikum und/oder Tumordiagnostikum, dadurch gekennzeichnet, dass das Gel in Gegenwart eines von Tumorzellen oder Tumorgewebe gebildeten Stimulus, insbesondere Lysyloxidase (LOX), destabilisiert und das Tumortherapeutikum und/oder Tumordiagnostikum freigesetzt werden kann, sowie ein pharmazeutische Zusammensetzung, welches dieses kationen–stabilisierte Biopolymer-Gel mit inkorporiertem Tumortherapeutikum/diagnostikum und gegebenenfalls einer zusätzlichen Reportersubstanzumfasst. Ein verwandter Aspekt der Erfindung betrifft ein in vitro Verfahren zum Nachweisder Anwesenheit und/oder Menge eines tumorspezifischen Produkts im Körper eines Patienten, welches dadurch gekennzeichnet ist, dass eine physiologische Probe eines Patienten, dem eine erfindungsgemäße pharmazeutische Zusammensetzung verabreicht wurde, aufdie Anwesenheit und/oder die Menge einer Reportersubstanz, welche nach der Destabilisierung des Gels infolge eines Kontakts mit dem nachzuweisenden tumorspezifischen Produkt freigesetzt wurde, untersucht und gegebenenfalls mit Referenzwerten verglichen wird.

Antibodies targeting baff-r and use thereof

Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

Design fob a coat

Verfahren zur Herstellung von vaskularisiertem biologischem Gewebe

Ein Verfahren zur Herstellung von vaskularisiertem biologischen Gewebe, umfasst die Schritte Herstellung einer Netzwerkstruktur aus einer Vielzahl von miteinander verbundenen Filamenten 11 eines Stützpolymers, Beschichtung der Netzwerkstruktur mit einem Proteinmaterial, Besiedlung der beschichteten Netzwerkstruktur mit Endothelzellen 2, 2A und mit Gewebe-bildenden biologischen Zellen 3, und Auflösung der Filamente 11, so dass das vaskularisierte Gewebe 1 gebildet wird. Das vaskularisierte Gewebe 1 umfasst z. B. Herzmuskelzellen, Leberzellen, Nierenzellen, Nervenzellen und/oder Pankreaszellen.

Child's sleeping garment

Proteínas que se unen a nkg2d, cd16 y baff-r

Se describen proteínas de unión multiespecíficas que se unen al receptor NKG2D, a CD16 y al receptor del factor activador del linfocito B (BAFF-R), así como composiciones farmacéuticas y métodos terapéuticos de las proteínas de unión multiespecíficas útiles para el tratamiento del cáncer y de enfermedades inflamatorias autoinmunitarias.

Design for a child s coat

Design for a child s coat

Method for producing vascularized biological tissue

The invention relates to a method for producing vascularized biological tissue, having the steps of producing a network structure made of a plurality of interconnected filaments ( 11 ) of a support polymer, coating the network structure with a protein material, populating the coated network structure with endothelial cells ( 2, 2 A) and tissue-forming biological cells ( 3 ), and dissolving the filaments ( 11 ) such that the vascularized tissue ( 1 ) is formed. The vascularized tissue ( 1 ) comprises cardiomyocytes, liver cells, renal cells, nerve cells, and/or pancreatic cells, for example.

Design fob a child s coat

Disposición para conducir, tratar y/o medir un fluido

Disposición (1) para su montaje en una tubería de una red de fluidos, que comprende una unidad funcional (10) sustituible y una carcasa de conexión (2), con una entrada (3), una salida (4) y una abertura de conexión (5) para la conexión de la unidad funcional (10), la carcasa de conexión (2) presenta una pieza de núcleo (6) dispuesta de manera giratoria, mediante cuyo giro puede bloquearse y/o liberarse el flujo del fluido a través de la carcasa de conexión (2), la pieza de núcleo (6) presenta un alojamiento (7) para la conexión de la unidad funcional (10), el alojamiento (7) así como la abertura de conexión (5) están orientados en la misma dirección, la unidad funcional (10) está unida con el alojamiento (7) y el giro de la pieza de núcleo (6) tiene lugar mediante el giro de la unidad funcional (10) unida con el alojamiento (7), y mediante el giro de la unidad funcional (10) puede liberarse y/o bloquearse el flujo a través de la carcasa de conexión (2) y la pieza de núcleo (6), caracterizada por que un soporte (13) fija la pieza de núcleo (6) a la carcasa de conexión (2) de manera giratoria, la unidad funcional (10) y el soporte (13) presentan medios para establecer una unión liberable mecánicamente entre la unidad funcional (10) y el soporte (13), y la unidad funcional (10) puede enclavarse en al menos una posición de giro con el soporte (13).

Proteins binding nkg2d, cd16 and baff-r

Multispecific binding proteins that bind NKG2D receptor, CD 16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Design fob combined ski pants

Proteinas que se unen al miembro d del grupo 2 de asesinos naturales (nkg2d), cumulo de diferenciacion 16(cd16) y receptor del factor activador de celulas b (baff-r).

Se describen proteínas de unión multiespecíficas que se unen al receptor NKG2D, a CD16 y al receptor del factor activador del linfocito B (BAFF-R), así como composiciones farmacéuticas y métodos terapéuticos de las proteínas de unión multiespecíficas útiles para el tratamiento del cáncer y de enfermedades inflamatorias autoinmunitarias.

Proteins binding nkg2d, cd16 and baff-r

Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Compuestos derivados de heterociclos con n como heteroatomos, inhibidores selectivos de actividad pi3k; composicion farmaceutica; utiles en el tratamiento de artritis reumatoide, psoriasis, enfermedades inflamatorias, autoinmunitarias, miastenia gravis, afecciones alergicas y cancer, entre otras.

Compuestos derivados de heterociclos con N como heteroátomos, inhibidores selectivos de actividad PI3K; composición farmacéutica; y método de tratamiento de artritis reumatoide, psoriasis, enfermedades inflamatorias, enfermedades autoinmunitarias, miastenia gravis, afecciones alérgicas y cáncer, entre otras.

Anticuerpos dirigidos al receptor del factor activador de celulas b (baff-r) y uso de los mismos.

Se describen proteínas con dominios variables de cadena ligera y cadena pesada de anticuerpos que se pueden aparear para formar un sitio de unión a antígeno dirigido a BAFF-R en una célula, composiciones farmacéuticas que comprenden tales proteínas y métodos terapéuticos que usan tales proteínas y composiciones farmacéuticas, que incluyen para el tratamiento del cáncer o una enfermedad autoinmunitaria.

Antibodies targeting baff-r and use thereof

Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

Blancos de irradiación para la producción de radioisótopos

Un blanco de irradiación para la producción de radioisótopos, que comprende por lo menos una placa que define una abertura central y un miembro central elongado que pasa a través de una abertura central de por lo menos una placa de manera que por lo menos una placa es retenida en el mismo, en donde por lo menos una placa y el miembro central elongado están ambos formados por materiales que producen molibdeno-99 (Mo-99) por medio de la captura de neutrones.