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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 10. Отображено 9.
11-05-2017 дата публикации

DISCOVERY OF THE FIRST SELECTIVE C5A2 RECEPTOR (C5L2/C5AR2) LIGANDS

Номер: US20170129921A1
Автор: Dimitrios Morikis, Christodoulos A. Floudas, Trent M. Woodruff, Matthew A. Cooper, Daniel E. Croker, Peter N. Monk, MORIKIS DIMITRIOS, FLOUDAS CHRISTODOULOS A, WOODRUFF TRENT M, COOPER MATTHEW A, CROKER DANIEL E, MONK PETER N, Morikis Dimitrios, Floudas Christodoulos A., Woodruff Trent M., Cooper Matthew A., Croker Daniel E., Monk Peter N.
Принадлежит:

A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided. 1. A method of selectively modulating the activity of C5a receptor 2 (C5aR2) , comprising exposing the receptor to a C5aR2 ligand that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1).2. The method of claim 1 , wherein the C5aR2 is on the surface of or inside a cell.3. The method of claim 2 , wherein the cell is in a subject or in culture.4. The method of claim 1 , wherein the ligand acts as a C5aR2 agonist or antagonist.5. The method of claim 1 , wherein the ligand is a polypeptide or peptide comprising SEQ ID NO:1 or SEQ ID NO:2.6. The method of claim 1 , wherein the ligand is a peptide comprising SEQ ID NO:1 or SEQ ID NO:2 claim 1 , or an analog claim 1 , sequence variant claim 1 , peptide surrogate claim 1 , or peptidomimetic of the peptide.7. A method of recruiting β-arrestin 2 in a cell claim 1 , modulating C5a-induced ERK1/2 activation in a macrophage claim 1 , selectively inhibiting release of IL-6 from a macrophage claim 1 , or any combination thereof claim 1 , comprising exposing the cell or macrophage to a C5aR2 ligand that selectively modulates C5aR2 compared to C5aR1.8. The method of claim 7 , wherein the cell or macrophage is in culture or in a subject.9. The method of claim 7 , wherein the ligand is a polypeptide or peptide comprising SEQ ID NO:1 or SEQ ID NO:2.10. The method of claim 7 , wherein the ligand is a peptide comprising SEQ ID NO:1 or SEQ ID NO:2 claim 7 , or an analog claim 7 , sequence variant claim 7 , peptide surrogate claim 7 , or peptidomimetic of the peptide.11. A method of treating a disease ...

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Номер записи: 1
06-12-2016 дата публикации

Compstatin analogs

Номер: US0009512180B2
Автор: Dimitrios Morikis, Ronald D. Gorham, Christodoulos A. Floudas, Meghan L. Bellows-Peterson, George A. Khoury, Georgios Archontis, Phanourios Tamamis, MORIKIS DIMITRIOS, GORHAM RONALD D, FLOUDAS CHRISTODOULOS A, BELLOWS-PETERSON MEGHAN L, KHOURY GEORGE A, ARCHONTIS GEORGIOS, TAMAMIS PHANOURIOS, Morikis Dimitrios, Gorham Ronald D., Floudas Christodoulos A., Bellows-Peterson Meghan L., Khoury George A., Archontis Georgios, Tamamis Phanourios
Принадлежит: The Regents of the University of California, The Trustees of Princeton University, University of Cyprus, UNIV CALIFORNIA, UNIV PRINCETON, UNIV OF CYPRUS, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF PRINCETON UNIVERSITY, UNIVERSITY OF CYPRUS

The disclosure describes compstatin analogs and methods of using such analogs for the treatment of complement-related disease and disorder.

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Номер записи: 2
12-03-2015 дата публикации

PROCESSES FOR PRODUCING SYNTHETIC HYDROCARBONS FROM COAL, BIOMASS, AND NATURAL GAS

Номер: US20150073188A1
Автор: Baliban Richard C., Elia Josephine A., Floudas Christodoulos A.
Принадлежит:

Methods of optimal refinery design utilizing a thermochemical based superstructure are provided. Methods of producing liquid fuels utilizing a refinery selected from a thermochemical based superstructure are provided. Thermochemical based superstructures are provided. Refineries are provided. 1. A superstructure for a refinery comprising:at least one synthesis gas production unit configured to produce at least one synthesis gas selected from the group consisting of a biomass synthesis gas production unit, a coal synthesis gas production unit and a natural gas synthesis gas production unit, wherein the selection of the at least one synthesis gas production unit is determined by a mixed-integer linear optimization model solved by a global optimization framework;a synthesis gas cleanup unit configured to remove undesired gases from the at least one synthesis gas;a liquid fuels production unit selected from the group consisting of a Fischer-Tropsch unit and a methanol synthesis unit, the Fischer-Tropsch unit being configured to produce a first output from the at least one synthesis gas, and the methanol synthesis unit being configured to produce a second output from the at least one synthesis gas, wherein the selection of the liquid fuels production unit is determined by the mixed-integer linear optimization model solved by the global optimization framework;a liquid fuels upgrading unit configured to upgrade the first output of the second output, wherein the type of liquid fuels upgrading unit is determined by the mixed-integer linear optimization model solved by the global optimization framework;a hydrogen production unit configured to produce hydrogen for the refinery;an oxygen production unit configured to produce oxygen for the refinery;a wastewater treatment network configured to process wastewater from the refinery and input freshwater into the refinery, wherein the type of wastewater treatment network is determined by a mixed-integer linear optimization model ...

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Номер записи: 3
05-05-2016 дата публикации

METHODS OF SEPARATING MOLECULES

Номер: US20160121258A1
Автор: FIRST Eric L., Floudas Christodoulos A., Hasan M.M. Faruque
Принадлежит:

Disclosed herein are new methods, machines, processes, and systems for separating molecules by determining better materials and process optimization conditions. As a result of these advances, this disclosure provides improved carbon dioxide capture, better flue gas treatments, and more efficient methods of purifying gases have been developed. Optimal sorbents can be obtained by using a computational screening method that selects microporous structures (e.g. zeolites and metal-organic frameworks) from a database of materials with the greatest potential for cost-effective separations. The disclosed methods are the first to consider both the size and shape of the adsorbent material. This is also the first disclosure to consider the process application and cost when selecting which material to use. 1. A method for separating molecules comprising:identifying molecules in need of separation;identifying potential adsorbents for separating the molecules;characterizing the pore structure of the said potential adsorbents;minimizing the cost of carbon dioxide capture and/or compression for potential adsorbents by solving a mathematical model;ranking potential adsorbents based on cost;treating the molecules in need of separation with a ranked potential adsorbent.2. The method of claim 1 , wherein the molecules in need of separating are chosen from hydrocarbons claim 1 , nitrogen claim 1 , oxygen claim 1 , carbon dioxide claim 1 , and water.3. The method of claim 2 , wherein the molecules in need of separating are chosen from CH claim 2 , CO claim 2 , N claim 2 , O claim 2 , and HO.4. The method of claim 2 , wherein the molecules in need of separating are chosen from CH claim 2 , CO claim 2 , and N.5. The method of claim 1 , comprising identifying minimum purity standards.6. The method of claim 1 , comprising identifying minimum recovery standards.7. The method of claim 1 , comprising ranking the potential adsorbents according to shape and size.8. The method of claim 1 , ...

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Номер записи: 4
19-11-2015 дата публикации

Compstatin analogs

Номер: US20150329594A1
Автор: Christodoulos A. Floudas, Dimitrios Morikis, George A. Khoury, Georgios Archontis, Meghan L. Bellows-Peterson, Phanourios TAMAMIS, Ronald D. Gorham, JR.
Принадлежит: PRINCETON UNIVERSITY, UNIVERSITY OF CALIFORNIA, University of Cyprus

The disclosure describes compstatin analogs and methods of using such analogs for the treatment of complement-related disease and disorder.

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Номер записи: 5
17-12-2015 дата публикации

Methods of separating molecules

Номер: US20150360166A1
Автор: Christodoulos A. Floudas, Eric L. FIRST, M.M. Faruque HASAN
Принадлежит: PRINCETON UNIVERSITY

Disclosed herein are new methods, machines, processes, and systems for separating molecules by determining better materials and process optimization conditions. As a result of these advances, this disclosure provides improved carbon dioxide capture, better flue gas treatments, and more efficient methods of purifying gases have been developed. Optimal sorbents can be obtained by using a computational screening method that selects microporous structures (e.g. zeolites and metal-organic frameworks) from a database of materials with the greatest potential for cost-effective separations. The disclosed methods are the first to consider both the size and shape of the adsorbent material. This is also the first disclosure to consider the process application and cost when selecting which material to use.

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Номер записи: 6
28-11-2000 дата публикации

Adaptive feedback control flow reactor

Номер: US6153149A
Автор: Christodoulos A. Floudas, Herschel A. Rabitz, Richard A. Yetter
Принадлежит: PRINCETON UNIVERSITY

A flow reactor providing a high degree of selectivity in the reaction of a feedstock to produce one or more end product compounds, which includes: side walls defining an elongated reactor unit having a length dimension along which the feedstock is reacted under varying conditions of energy and chemical flux effective to produce the one or more end product compounds; a plurality of devices for supplying energy or chemical flux through the side walls and positioned to distribute the energy and chemical flux along the length of the reactor unit so as to optimize a property of the one or more end product compounds; devices for measuring a property of the end product compounds; and an adaptive feedback control system to determine, establish and maintain the optimum energy and chemical flux distribution along the length of the reactor based on the end product property measurement.

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Номер записи: 7
26-03-2019 дата публикации

Methods of separating molecules

Номер: US10239012B2
Автор: Christodoulos A. Floudas, Eric L. FIRST, M. M. Faruque Hasan
Принадлежит: PRINCETON UNIVERSITY

Disclosed herein are new methods, machines, processes, and systems for separating molecules by determining better materials and process optimization conditions. As a result of these advances, this disclosure provides improved carbon dioxide capture, better flue gas treatments, and more efficient methods of purifying gases have been developed. Optimal sorbents can be obtained by using a computational screening method that selects microporous structures (e.g. zeolites and metal-organic frameworks) from a database of materials with the greatest potential for cost-effective separations. The disclosed methods are the first to consider both the size and shape of the adsorbent material. This is also the first disclosure to consider the process application and cost when selecting which material to use.

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Номер записи: 8
14-08-2014 дата публикации

Methods of separating molecules

Номер: WO2014124035A1
Автор: Christodoulos A. Floudas, Eric L. FIRST, M.M. Faruque HASAN
Принадлежит: THE TRUSTEES OF PRINCETON UNIVERSITY

Disclosed herein are new methods, machines, processes, and systems for separating molecules by determining better materials and process optimization conditions. As a result of these advances, this disclosure provides improved carbon dioxide capture, better flue gas treatments, and more efficient methods of purifying gases have been developed. Optimal sorbents can be obtained by using a computational screening method that selects microporous structures (e.g. zeolites and metal-organic frameworks) from a database of materials with the greatest potential for cost-effective separations. The disclosed methods are the first to consider both the size and shape of the adsorbent material. This is also the first disclosure to consider the process application and cost when selecting which material to use.

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Номер записи: 9