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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 19. Отображено 19.
28-08-2014 дата публикации

METHOD FOR DETECTING AND/OR QUANTIFYING AN ANALYTE AT THE SURFACE OF A CELL

Номер: US20140242611A1
Автор: Hervé Bazin, Gérard Mathis, BAZIN HERVÉ, MATHIS GÉRARD
Принадлежит: CISBIO BIOASSAYS

The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.

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Номер записи: 1
04-05-1990 дата публикации

Complexes tridimensionnels à base de streptavidine (ou avidine) et de composés luminescents polybiotinylés

Номер: FR0002638462A
Автор: Odette Prat, Gérard Mathis, Etienne Jolu
Принадлежит:

L'invention concerne des complexes tridimensionnels constitués d'au moins une molécule de streptavidine (ou avidine) liée par liaison d'affinité à au moins un composé luminescent polybiotinylé ou à au moins une macromolécule polybiotinylée couplée à au moins un composé luminescent, l'un au moins des sites de liaison par affinité de la streptavidine (avidine) avec la biotine étant libre. Application : marqueurs pour dosages immunologiques ou pour la détection ou détermination d'acides nucléiques-cibles.

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Номер записи: 2
08-01-2019 дата публикации

Anti-mGluR2 conformational single domain antibodies and uses thereof

Номер: US0010174115B2
Автор: Daniel Baty, Jean-Philippe Pin, Patrick Chames, Damien Nevoltris, Philippe Rondard, Pauline Scholler, Gérard Mathis, BATY DANIEL, PIN JEAN-PHILIPPE, CHAMES PATRICK, NEVOLTRIS DAMIEN, RONDARD PHILIPPE, SCHOLLER PAULINE, MATHIS GÉRARD, Baty, Daniel, Pin, Jean-Philippe, Chames, Patrick, Nevoltris, Damien, Rondard, Philippe, Scholler, Pauline, Mathis, Gérard
Принадлежит: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE MONTPELLIER, CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ PARIS-SUD, INST NAT SANTE RECH MED, UNIV AIX MARSEILLE, UNIV MONTPELLIER, CENTRE NAT RECH SCIENT, INST JEAN PAOLI & IRENE CALMETTES, UNIV PARIS SUD, UNIV VERSAILLES SAINT QUENTIN EN YVELINES, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE VERSAILLES SAINT-QUENTIN-EN-YVELINES

The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.

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Номер записи: 3
22-01-2002 дата публикации

Fluorescent conjugates of nucleosides or nucleotides, process for their preparation and their uses

Номер: US0006340747B1
Автор: Hervé Bazin, Gérard Mathis, BAZIN HERVE, MATHIS GERARD, BAZIN HERV, MATHIS GRARD
Принадлежит: CIS BIO International, CIS BIO INT, CIS BIO INTERNATIONAL

The invention relates to novel fluorescent conjugates of nucleosides or nucleotides which can be used especially for detecting, locating and/or isolating nucleic acids or molecules of biological or clinical interest which have a nucleoside structure or are capable of interacting with nucleic acids. The invention further relates to the polynucleotides comprising at least one fluorescent conjugate of a nucleotide.

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Номер записи: 4
16-08-2011 дата публикации

Method of revealing a biological process using a FRET measurement

Номер: US0007998694B2
Автор: Eric Trinquet, Hervé Ansanay, Gérard Mathis, TRINQUET ERIC, ANSANAY HERVE, MATHIS GERARD
Принадлежит: CIS BIO International, CIS BIO INT, CIS BIO INTERNATIONAL

The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps: incorporating, into a measurement medium containing a lipid membrane, a biological entity X coupled with a first member of a pair of FRET partners and a second biological entity Y coupled with the second member of the pair of FRET partners, the energy-donating member of the pair of FRET partners having a long lifetime and the members of said pair of FRET partners being located on either side of the lipid membrane; exciting the measurement medium at the excitation wavelength of the energy-donating member; and measuring the FRET signal or the variations in said signal emitted in said culture medium.

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Номер записи: 5
14-05-2019 дата публикации

Anti-EGFR conformational single domain antibodies and uses thereof

Номер: US0010287360B2
Автор: Daniel Baty, Patrick Chames, Damien Nevoltris, Gérard Mathis, BATY DANIEL, CHAMES PATRICK, NEVOLTRIS DAMIEN, MATHIS GÉRARD, Baty, Daniel, Chames, Patrick, Nevoltris, Damien, Mathis, Gérard
Принадлежит: INSERM (Institut National de la Santé et de la Recherche Médicale, Université d' Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), CISBIO Bioassays, Institut Jean Paoli & Irene Calmettes, INST NAT SANTE RECH MED, UNIV AIX MARSEILLE, CENTRE NAT RECH SCIENT, CISBIO BIOASSAYS, INST JEAN PAOLI & IRENE CALMETTES, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES

The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.

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Номер записи: 6
04-03-2014 дата публикации

Method for the detection of post-translational modifications

Номер: US0008663928B2
Автор: Eric Trinquet, Achim Brinker, Emmanuel Claret, Gérard Mathis, TRINQUET ERIC, BRINKER ACHIM, CLARET EMMANUEL, MATHIS GERARD
Принадлежит: CIS BIO International, TRINQUET ERIC, BRINKER ACHIM, CLARET EMMANUEL, MATHIS GERARD, CIS BIO INT, CIS BIO INTERNATIONAL

Method for the detection in homogeneous medium of a post-translational modification of a proteinaceous substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the proteinaceous substrate and a first coupling domain and in that it comprises the following stages: (i) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (ii) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the proteinaceous substrate, (iii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific ...

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Номер записи: 7
18-01-2011 дата публикации

Method for improving the detection of fluorescence signals during a resonance energy transfer

Номер: US0007872243B2
Автор: Eric Trinquet, Gérard Mathis, TRINQUET ERIC, MATHIS GERARD
Принадлежит: CIS BIO International, CIS BIO INT, CIS BIO INTERNATIONAL

The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium.

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Номер записи: 8
15-05-2012 дата публикации

Inositol-phosphate derivatives and method of detecting inositol-1-phosphate

Номер: US0008178704B2
Автор: Hervé Bazin, Hervé Ansanay, Eric Trinquet, Gérard Mathis, BAZIN HERVE, ANSANAY HERVE, TRINQUET ERIC, MATHIS GERARD
Принадлежит: CIS Bio International, BAZIN HERVE, ANSANAY HERVE, TRINQUET ERIC, MATHIS GERARD, CIS BIO INT, CIS BIO INTERNATIONAL

The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.

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Номер записи: 9
26-07-2012 дата публикации

METHOD FOR DETERMINING THE BINDING OF A GIVEN COMPOUND TO A MEMBRANE RECEPTOR

Номер: US20120190048A1
Автор: Eric Trinquet, Jurriaan Zwier, Gérard Mathis, Jean-Philippe Pin, Thierry Durroux, TRINQUET ERIC, ZWIER JURRIAAN, MATHIS GERARD, PIN JEAN-PHILIPPE, DURROUX THIERRY
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CIS BIO INTERNATIONAL

The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one or two FRET partner pairs.

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Номер записи: 10
12-04-2005 дата публикации

Homogeneous detection and/or determination method for a chemical or physico-chemical interaction

Номер: US0006878552B1
Автор: Gérard Mathis, Hervé Bazin, MATHIS GERARD, BAZIN HERVE
Принадлежит: Cis Bio International French Joint Stock Company, CIS BIO INTERNAT FRENCH JOINT, CIS BIO INTERNATIONAL FRENCH JOINT STOCK COMPANY

The invention relates to a homogeneous method for detecting and/or determining by fluorescence a chemical or physicochemical interaction in a measuring medium, in which a rare-earth metal cryptate comprising a substituent is used, characterized in that the variation of at least one fluorescence characteristic of the rare-earth metal cryptate, induced by the change in the physicochemical properties of the substituent resulting from said interaction, is measured.

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Номер записи: 11
15-04-2014 дата публикации

Method for determining the binding of a given compound to a membrane receptor

Номер: US0008697372B2
Автор: Eric Trinquet, Jurriaan Zwier, Gérard Mathis, Jean-Philippe Pin, Thierry Durroux, TRINQUET ERIC, ZWIER JURRIAAN, MATHIS GÉRARD, PIN JEAN-PHILIPPE, DURROUX THIERRY
Принадлежит: CIS Bio International, Centre National de la Recherche Scientifique, TRINQUET ERIC, ZWIER JURRIAAN, MATHIS GÉRARD, PIN JEAN-PHILIPPE, DURROUX THIERRY, CIS BIO INT, CENTRE NAT RECH SCIENT, CIS BIO INTERNATIONAL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one or two FRET partner pairs.

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Номер записи: 12
08-04-2010 дата публикации

METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS

Номер: US20100086943A1
Автор: Eric Trinquet, Achim Brinker, Emmanuel Claret, Gérard Mathis, TRINQUET ERIC, BRINKER ACHIM, CLARET EMMANUEL, MATHIS GERARD
Принадлежит: CIS BIO INTERNATIONAL

Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the ...

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Номер записи: 13
03-09-2009 дата публикации

METHOD OF REVEALING A BIOLOGICAL PROCESS USING A FRET MEASUREMENT

Номер: US20090220988A1
Автор: Eric Trinquet, Hervè Ansanay, Gérard Mathis
Принадлежит:

The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps: incorporating, into a measurement medium containing a lipid membrane, a biological entity X coupled with a first member of a pair of FRET partners and a second biological entity Y coupled with the second member of the pair of FRET partners, the energy-donating member of the pair of FRET partners having a long lifetime and the members of said pair of FRET partners being located on either side of the lipid membrane; exciting the measurement medium at the excitation wavelength of the energy-donating member; and measuring the FRET signal or the variations in said signal emitted in said culture medium.

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Номер записи: 14
25-06-2013 дата публикации

Method for detecting intracellular interaction between biomolecules

Номер: US0008470523B2
Автор: Iris Pribilla, Hervé Bazin, Sraboni Ghose, Norbert Tinel, Michel Fink, Eric Trinquet, Gérard Mathis, PRIBILLA IRIS, BAZIN HERVE, GHOSE SRABONI, TINEL NORBERT, FINK MICHEL, TRINQUET ERIC, MATHIS GERARD
Принадлежит: CIS BIO International, PRIBILLA IRIS, BAZIN HERVE, GHOSE SRABONI, TINEL NORBERT, FINK MICHEL, TRINQUET ERIC, MATHIS GERARD, CIS BIO INT, CIS BIO INTERNATIONAL

The invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules in living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.

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Номер записи: 15
05-03-2002 дата публикации

Apparatus for measuring the luminescence emitted in a luminescent assay

Номер: US0006352672B1
Автор: Michel Mabile, Gérard Mathis, Etienne Jean-Pierre Jolu, Dominique Pouyat, Christophe Dumont, MABILE MICHEL, MATHIS GERARD, JOLU ETIENNE JEAN-PIERRE, POUYAT DOMINIQUE, DUMONT CHRISTOPHE, MATHIS GRARD
Принадлежит: CIS bio international, CIS BIO INT, CIS BIO INTERNATIONAL

The present invention relates to an apparatus for measuring the luminescence emitted in a luminescent assay, which makes it possible to correct certain perturbations due to the measuring medium.

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Номер записи: 16
25-06-2009 дата публикации

METHOD FOR SUPPRESSING A FRET SIGNAL, FRET SIGNAL SUPPRESSOR AGENTS AND USE IN A METHOD FOR MULTIPLEXING BIOLOGICAL EVENTS

Номер: US20090162861A1
Автор: Gérard Mathis, Eric Trinquet, Patrizia Alberti, Michel Laget
Принадлежит:

The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium.

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Номер записи: 17
29-01-2013 дата публикации

Method for suppressing a FRET signal, FRET signal suppressor agents and use in a method for multiplexing biological events

Номер: US0008361715B2
Автор: Gérard Mathis, Eric Trinquet, Patrizia Alberti, Michel Laget, MATHIS GERARD, TRINQUET ERIC, ALBERTI PATRIZIA, LAGET MICHEL
Принадлежит: CIS Bio International, CIS BIO INT, MATHIS GERARD, TRINQUET ERIC, ALBERTI PATRIZIA, LAGET MICHEL, CIS BIO INTERNATIONAL

The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium.

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Номер записи: 18
22-06-2004 дата публикации

Homogeneous method for detecting and/or determining phosphorylating activity in a biological material

Номер: US0006753156B1
Автор: Gérard Mathis, Eric Trinquet, Marc Preaudat, MATHIS GERARD, TRINQUET ERIC, PREAUDAT MARC
Принадлежит: Cis Bio International, CIS BIO INT, CIS BIO INTERNATIONAL

The invention relates to a novel homogeneous method of detecting and/or determining the phosphorylating activity of a biological material towards a substrate containing tyrosine and/or serine and/or threonine, and to a kit for carrying out this method.

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Номер записи: 19