20-04-2017 дата публикации
Номер: US20170107212A1
Автор:
Kai THEDE,
Eckhard BENDER,
William SCOTT,
Anja GIESE,
Ludwig ZORN,
Ningshu LIU,
Ursula MÖNNING,
Franziska SIEGEL,
Stefan GOLZ,
Andrea HÄGEBARTH,
Philip LIENAU,
Florian PUEHLER,
Daniel BASTING,
Dirk SCHNEIDER,
Manfred MÖWES,
Jens GEISLER,
THEDE KAI,
BENDER ECKHARD,
SCOTT WILLIAM,
GIESE ANJA,
ZORN LUDWIG,
LIU NINGSHU,
MÖNNING URSULA,
SIEGEL FRANZISKA,
GOLZ STEFAN,
HÄGEBARTH ANDREA,
LIENAU PHILIP,
PUEHLER FLORIAN,
BASTING DANIEL,
SCHNEIDER DIRK,
MÖWES MANFRED,
GEISLER JENS,
THEDE Kai,
BENDER Eckhard,
SCOTT William,
GIESE Anja,
ZORN Ludwig,
LIU Ningshu,
MÖNNING Ursula,
SIEGEL Franziska,
GOLZ Stefan,
HÄGEBARTH Andrea,
LIENAU Philip,
PUEHLER Florian,
BASTING Daniel,
SCHNEIDER Dirk,
MÖWES Manfred,
GEISLER Jens
Принадлежит:
The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients. 5. A compound according to claim 1 , wherein:{'sup': '4', 'Rrepresents a hydrogen atom, and'}{'sup': '5', 'Rrepresents a hydrogen atom.'}6. A compound according to claim 1 , wherein:{'sup': '6', 'Rrepresents a group selected from{'sub': 1', '6', '1', '6', '3', '6', '1', '6', '1', '6', '1', '4', '2, 'sup': 9', '10', '9', '9, 'C-C-alkyl-, C-C-alkoxy-, C-C-cycloalkoxy-, halo-, hydroxy-, fluoro-C-C-alkyl-, fluoro-C-C-alkoxy-, phenyl-, 5- to 6-membered heteroaryl-, cyano-, —C(═O)—O—C-C-alkyl, —C(═O)—N(R)(R), R—S(═O)—, R—S(═O)—;'}{'sub': 1', '6', '1', '6', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3', '2', '3', '3', '7', '1', '4, 'sup': 9', '9', '9', '10', '9', '10', '9', '11', '10', '9', '9', '10', '9', '9', '10', '9, 'said C-C-alkyl- or C-C-alkoxy- group being optionally substituted, one or more times, identically or differently, with a substituent selected from: C-C-alkyl-, C-C-alkoxy-, halo-C-C-alkoxy-, hydroxy-C-C-alkoxy-, C-C-alkoxy-C-C-alkoxy-, C-C-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R, —C(═O)O—(C-C-alkyl), —OC(═O)—R, —N(H)C(═O)R, —N(R)C(═O)R, —N(H)C(═O)NRR, —N(R)C(═O)NRR, —N(H)R, —NRR, —C(═O)N(H)R, —C(═O)NRR.'}7. A compound according to claim 1 , wherein:{'sup': '6', 'Rrepresents a group selected from{'sub': 1', '6', '1', '6', '3', '6', '1', '4', '2, 'sup': 9', '10', '9', '9', '9, 'CCalkyl , C-C-alkoxy-, C-C-cycloalkoxy-, halo-, hydroxy-, cyano-, —C(═O)—O—C-C-alkyl, —C(═O)—N(R)(R), ...
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