Targeted APLNR protein palmitoylation modified polypeptide and application thereof in cancer pain treatment

The invention discloses a targeted APLNR protein palmitoylation modified polypeptide and application of the targeted APLNR protein palmitoylation modified polypeptide in cancer pain treatment, and particularly relates to application of APLNR protein and a palmitoylation modified site of the APLNR protein in relieving morphine drug resistance in cancer pain treatment. The invention finds that APLNR palmitoylation modification is one of important response factors for occurrence of neuropathic cancer pain, the polypeptide targeted to APLNR protein palmitoylation modification is developed by taking the APLNR protein as a target spot, and the polypeptide is combined with morphine to treat cancer pain, so that cancer pain can be effectively reduced, morphine tolerance can be relieved, and the application of the APLNR protein palmitoylation modification in neuropathic cancer pain treatment is facilitated. A new strategy is provided for clinically treating cancer pain and relieving morphine tolerance ...