Method and apparatus for controlling a microscope

Improvements in imaging microscope samples

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

Improvements in imaging microscope samples

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

SORTING

An image scanning apparatus and methods of operating an image scanning apparatus

Image scanning apparatus and method of operating an image scanning apparatus, the image scanning apparatus including a line scan detector and being configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction.

DIGITIZING MICROSCOPE SLIDES

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals. 1. A microscope scanner comprising:a detector array for obtaining an image from a sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array; anda controller configured to issue position control signals so as to control the relative position of the sample holder;wherein the sample holder is configured to move to a plurality of target positions relative to the detector array during an imaging scan in accordance with the position control signals, and wherein said detector array is configured to capture images based on the position control signals during the imaging scan.2. The microscope scanner of claim 1 , wherein the plurality of target positions corresponds to a target velocity profile.3. The microscope scanner of claim 2 , wherein the target velocity profile is stored on a memory accessible by the controller.4. The microscope scanner of claim 1 , further comprising a motor adapted to drive the sample holder claim 1 , wherein the position control signal is based on a desired motor operation.5. The microscope scanner of claim 4 , wherein the motor is a stepper motor having an associated step count claim 4 , and wherein image capture is triggered in accordance with said step count.6. The microscope scanner of claim 4 , wherein the motor is a servomotor.7. The microscope scanner of claim 1 , wherein the controller is further configured to monitor the position of the sample holder.8. The microscope scanner of claim 1 , wherein the ...

METHOD AND APPARATUS FOR CONTROLLING A MICROSCOPE

In accordance with the present invention there is provided a method for controlling a microscope to scan a microscope slide. By analysing an overview image it is determined quantatively which swathe contains the most image detail and an optimum scanning order can subsequently be determined relative to the swathe determined as having the most detail. By scanning the swathe with the most detail first a good focus characteristic can be established for a dynamic focussing system and prediction errors in the dynamic focus system are likely to be low when scanning subsequent swathes.

SORTING ACCORDING TO SHAPE

IMPROVEMENTS IN DIGITISING MICROSCOPE SLIDES

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder is configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

Image scanning apparatus and method

An image scanning apparatus comprises a time delay integration sensor for obtaining first image information from a target and a scan device for causing relative motion between the time delay integration sensor and the target. The image scanning apparatus is characterized by detector array for obtaining second image information from a target, wherein the first image information corresponds to a first portion of light received from the target and the second image information corresponds to a second portion of light received from the target.

Method and apparatus for image scanning

A method of estimating an in-focus level of a target in an image scanning apparatus, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target, the second line scan detector comprising at least one focus shifting element such that each focus scan line is obtained at respective first and second focus levels, wherein the first focus level is different from the second focus level, the method comprising: obtaining at least one focus scan line of the target using the second line scan detector; obtaining at least one image scan line of the target using the first line scan detector, the image scan line being obtained at a respective third focus level; calculating at least one focus parameter using the at least one focus scan line; and estimating a nominal in-focus level of the target using the at least one focus parameter ...

Verfahren und Vorrichtung zur Erzeugung einer digitalen Bilddarstellung

IMPROVEMENTS IN DIGITISING MICROSCOPE SLIDES

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder is configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

METHOD AND DEVICE FOR PREDICTING FOCUS POSITION

PROBLEM TO BE SOLVED: To solve a problem that if the focus for a target varies quickly, in an image forming apparatus, many points to be measured before scanning are needed and the productivity of the apparatus is significantly degraded. SOLUTION: A first portion of the target is scanned at a nominal focus level to acquire corresponding image information. One or more different portions of the target are scanned at one or more different focus levels to acquire corresponding image information. Then, by using each piece of the image information, a focus parameter is calculated for each of one or more different focus levels. Then, a focus position common to each of the first and other portions of the target is predicted using the calculated focus parameter. COPYRIGHT: (C)2007,JPO&INPIT ...

Controlling focus in a microscope

In controlling a microscope (100) to scan a microscope slide, the slide is divided into swathes (0 to 9). By analysing 303 an overview image (400) it is determined 304 quantitatively which swathe contains the most image detail and an optimum scanning order can subsequently be determined relative to the swathe determined as having the most detail. By scanning the swathe (4) with the most detail first a good focus characteristic can be established for a dynamic focusing system and prediction errors in the dynamic focus system are likely to be low when scanning subsequent swathes.

Method for forming an image reference device

A method is provided of forming an imaging reference device for a biological material imaging system. A first region is provided in a substrate formed from an optically transmissive material which is an analogue of biological tissue. This first region is stained using a first biological tissue stain. A second region is provided in second substrate which is optically transmissive and an analogue of biological tissue. The second region is stained with a second biological tissue stain. The first and second regions are overlapped as a pair, such that light incident upon the pair is modulated by the respective first and second biological tissue stains of the respective regions. Multiple regions of the first and second type may be provided, stained to different degrees.

SORTING ACCORDING TO SHAPE

Improvements in digitising microscope slides

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder is configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

METHOD AND APPARATUS FOR FORMING A MULTIPLE FOCUS STACK IMAGE

A method of producing a multiple focus stack image of a target, the stack image comprising a plurality of images of the target, each image having a corresponding focal range or position, wherein the method comprises causing relative scanning movement between the target and an array of light detectors, the array being used to repeatedly receive image information from the target during the scan in the form of scan lines; and causing the relative focus between the target and the array to be modified between the said focal ranges or positions of the respective images during the scan so as to obtain scan lines corresponding to each focal range or position during the scan, thereby obtaining the images in the stack, wherein each image is formed from the image information obtained as scan lines at the respective focal range or position during the scan. The method is then further characterised in that the relative focus is cycled between two extreme focal ranges or positions during the relative ...

Method and apparatus for forming a multiple focus stack image

A method of producing a multiple focus stack image of a target, the stack image comprising a plurality of images of the target, each image having a corresponding focal range or position, wherein the method comprises causing relative scanning movement between the target and an array of light detectors, the array being used to repeatedly receive image information from the target during the scan in the form of scan lines; and causing the relative focus between the target and the array to be modified between the said focal ranges or positions of the respective images during the scan so as to obtain scan lines corresponding to each focal range or position during the scan, thereby obtaining the images in the stack, wherein each image is formed from the image information obtained as scan lines at the respective focal range or position during the scan. The method is then further characterized in that the relative focus is cycled between two extreme focal ranges or positions during the relative ...

Abtastgerät

VERFAHREN UND VORRICHTUNG ZUM ERKENNEN DER REGISTERPASSMARKEN.

Method of forming an imaging reference device

A method is provided of forming an imaging reference device (or calibration standard) 10 for a biological material imaging system. A first region is provided in a substrate formed from an optically transmissive material which is an analogue of biological tissue. This first region is stained using a first biological tissue stain. A second region is provided in a second substrate which is optically transmissive and an analogue of biological tissue. The second region is stained with a second biological tissue stain. The first and second regions are overlapped as a pair, such that light incident upon the pair is modulated by the respective first and second biological tissue stains of the respective regions. Multiple regions of the first and second type may be provided, stained to different degrees. The substrates may be formed from a material such as cellophane (RTM), cellulose, agar, agarose or gelatine. The stains may be those used for the Haematoxylin and Eosin (H&E) staining protocol.

Providing a patterned layer on a substrate

A method of providing on a substrate (1) a patterned layer of a curable material forming an area which at least partly defines an accurate border line. The method comprises:

Sorting objects according to shape

A rapid succession of objects such as sweets are sorted according to shape by being fed through a viewing zone, flash illuminated in the viewing zone, and viewed by a number of fixed electronic viewers spaced in one plane around the viewing zone through just under 180 DEG , the edges of the images produced by the viewers being examined for approximation to a spherical shape, approximation to symmetry and reentrants, and one of a number of air jet nozzles being thereby automatically energised to direct the object into an appropriate bin.

Providing a patterned layer on a substrate

IMPROVEMENTS IN IMAGING MICROSCOPE SAMPLES

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

Farbabänderung von Bildern

Verfahren und Vorrichtung zur Generierung eines Bitmapbildes

An image scanning apparatus and methods of operating an image scanning apparatus

Image scanning apparatus and method of operating an image scanning apparatus, the image scanning apparatus including a line scan detector and being configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction.

AN IMAGE SCANNING APPARATUS AND METHODS OF OPERATING AN IMAGE SCANNING APPARATUS

Image scanning apparatus and method of operating an image scanning apparatus, the image scanning apparatus including a line scan detector and being configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction.

IMPROVEMENTS IN IMAGING MICROSCOPE SAMPLES

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

Method and apparatus for estimating an in-focus position

A method for estimating an in-focus position of a target using an image scanning apparatus is provided. The in-focus position is monitored at a seed location and an end location on the target and a pre-scan path is calculated between these locations. A pre-scan is then performed and a focus parameter is monitored for a plurality of locations along the pre-scan path. An imaging scan is next performed wherein the target is imaged along an image scan path and a focus parameter is monitored for a plurality of locations along said path. The focal height of the apparatus is adjusted during the imaging scan by comparing the focal parameter monitored for a current location on the image scan path with the focal parameter monitored for a similar location on the pre-scan path. The focal parameter monitored for different locations on the image scan path may also be compared.

Verfahren und Vorrichtung zur Erzeugung einer digitalen Bilddarstellung

Method of printing digital images

A method of printing using a print head comprising first and second print arrays, each comprising a plurality of nozzles. Each of the first print array nozzles emits a droplet of a first volume and each of the second print array nozzles emits a droplet of a second volume, wherein the first volume is less than the second volume. The method comprises: a. receiving image data comprising a received tone value for a pixel; b. selecting one of the print arrays corresponding to the pixel location; c. mapping the received tone value to a mapped tone value using a tone mapping for the selected print array; d. comparing the mapped tone value with a threshold value for the location of the pixel; and e. generating a control signal for the selected print array if the mapped tone value corresponds to the threshold value in a predetermined manner.

Estimating an in-focus level of a target in an image scanning apparatus

Estimating an in-focus level of a target in an image scanning apparatus is accomplished with first line scan detector 26 configured to obtain one or more image scan lines of the target and a second line scan detector 11 configured to obtain one or more focus scan lines of the target. The second line scan detector has at least one focus shifting element such that each focus scan line is obtained at 2 different focus levels. This may be achieved by having transparent windows 13 which have a different overall refractive index when compared to other parts of the line sensor. The method consists of obtaining at least one focus scan line of the target using the second line scan detector; obtaining at least one image scan line of the target using the first line scan detector, the image scan line being obtained at a respective third focus level; calculating at least one focus parameter using the at least one focus scan line; and estimating a nominal in-focus level of the target using the at least ...

Improvements in digitising microscope slides

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder is configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

Improvements in imaging microscope samples

IMPROVEMENTS IN IMAGING MICROSCOPE SAMPLES A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

INK PINNING ASSEMBLY

An ink pinning assembly comprises a source of UV radiation suitable for pinning ink on a record medium. A radiation guide device has an inlet facing the source and an outlet through which radiation is emitted towards a record medium, in use, the length of the inlet being greater that the length of the radiation source. The radiation guide device has a substantially rectangular or square wall in plan surrounding a cavity extending between the inlet and outlet, the internal surface of the wall being reflective to the pinning radiation so that pinning radiation with a substantial uniform intensity is emitted from the outlet.

SORTIERUNG.

Tintenbefestigungsanordnung

VERFAHREN UND VORRICHTUNG ZUM ERKENNEN DER REGISTERPASSMARKEN.

Method and Apparatus for Imaging a Sample Using a Microscope Scanner

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals. 1. A microscope scanner comprising:a detector array for obtaining an image from a sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array; anda controller configured to issue position control signals so as to control the relative position of the sample holder;wherein the sample holder is configured to continuously move to a plurality of target positions relative to the detector array during an imaging scan in accordance with the position control signals, and wherein said detector array is configured to capture images while the sample holder is in motion based on the position control signals issued during the imaging scan.2. The microscope scanner of claim 1 , wherein the plurality of target positions corresponds to a target velocity profile.3. The microscope scanner of claim 2 , wherein the target velocity profile is stored on a memory accessible by the controller.4. The microscope scanner of claim 1 , further comprising a motor adapted to drive the sample holder.5. The microscope scanner of claim 4 , wherein the position control signal is based on a desired motor output.6. The microscope scanner of claim 4 , wherein the motor is a stepper motor having an associated step count claim 4 , and wherein image capture is triggered in accordance with said step count.7. The microscope scanner of claim 4 , wherein the motor is a servomotor.8. The microscope scanner of claim 1 , wherein the controller is further configured to monitor the ...

METHOD AND DEVICE FOR GENERATING BIT MAP EXPRESSING ORIGINAL IMAGE AND FOR GENERATING OUTPUT IMAGE FROM PLURAL SEPARATED COLORS

PROBLEM TO BE SOLVED: To decrease the amount of image data required to be processed by scanning an original image more speedily. SOLUTION: A method for generating a bit map includes a step for scanning the original image for generating a gray scale pixel map, a step for interpolating and rotating the gray scale pixel map for generating a gray scale pixel map having higher resolution, and a step for converting the higher-resolution gray scale pixel map into a bit map. In this case, (i) gray scale pixel values are ranked corresponding to respective gray scale pixel values near the adjacent pixel positions (104), (ii) the desired number of nearby black binary pixels (B-Pc) is determined (106), (iii) the rank of gray scale pixel is compared with the desired number of black binary pixels (108 and 110) and (iv) the black binary pixel is allocated to the pixel position, when the comparison in (iii) satisfies predetermined conditions (109) so that the gray scale pixel map can be converted into ...

Method of forming an imaging calibration device

A method of forming an imaging calibration device for a biological material imaging system, the method comprises: providing one or more discrete regions upon or within a retaining member, each region for the receipt of a selected predetermined biological stain material; selecting one or more predetermined biological stain materials, wherein each of the selected predetermined biological stain materials has a predetermined optical response, and providing one or more of the selected predetermined biological stain materials to the said one or more discrete regions such that the said material is localised in the said region.

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

Farbabänderung von Bildern

REPRODUZIEREN VON BILDERN.

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

Method and apparatus for image scanning

A method of estimating an in-focus level of a target in an image scanning apparatus is provided, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target. The method comprises obtaining at least one image scan line of the target using the first line scan detector, each at least one image scan line being obtained at a respective focus level; obtaining at least one focus scan line of the target using the second line scan detector, each at least one focus scan line being obtained at a respective focus level; calculating at least one focus parameter using at least one focus scan line; and estimating a nominal in-focus level of the target using the calculated focus parameter(s).

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

METHOD AND APPARATUS FOR FORMING MULTIPLE FOCUS STACK IMAGE

PROBLEM TO BE SOLVED: To provide a method for forming a multiple focus stack image of a target. SOLUTION: A method is provided of producing a multiple focus stack image of a target. The stack image has a plurality of images of the target, each image having a corresponding focal range or position. The method utilizes relative scanning movement between the target and an array of light detectors, the array being used to repeatedly receive image information as scan lines from the target during the scan. During the scan the relative focus between the target and the array is modified between the focal range or position of the respective images so as to obtain the images in the stack. Each image is thereby formed from the image information obtained at the respective focal range or position during the scan. Apparatus for performing the method is likewise provided. COPYRIGHT: (C)2006,JPO&NCIPI ...

VERFAHREN ZUM DRUCKEN DIGITALER BILDER

Ein Verfahren zum Erzeugen einer Druckausgabe auf einem Substrat unter Verwendung eines Druckkopfs wird bereitgestellt. Der Druckkopf umfasst erste und zweite Druckarrays, wobei die ersten und zweiten Druckarrays jeweils eine Vielzahl von Düsen umfassen. Jede der Düsen des ersten Druckarrays ist zum Abgeben eines Tröpfchens eines ersten Volumens konfiguriert und jede der Düsen des zweiten Druckarrays ist zum Abgeben eines Tröpfchens eines zweiten Volumens konfiguriert, wobei das erste Volumen kleiner als das zweite Volumen ist. Das Verfahren umfasst die folgenden Schritte: a. Empfangen von Bilddaten, die einen empfangenen Farbtonwert für ein Pixel in einem zu druckenden Bild umfassen; b. Auswählen eines der Druckarrays aus den ersten und zweiten Druckarrays mit einer Düse, die der Position des Pixels im zu druckenden Bild entspricht, wobei jede Düse der ersten und zweiten Druckarrays zum Drucken eines jeweils anderes Pixels in den Bilddaten eingerichtet ist; c. Abbilden des empfangenen ...

Method and apparatus for controlling a microscope

In accordance with the present invention there is provided a method for controlling a microscope to scan a microscope slide. By analyzing an overview image it is determined quantatively which swathe contains the most image detail and an optimum scanning order can subsequently be determined relative to the swathe determined as having the most detail. By scanning the swathe with the most detail first a good focus characteristic can be established for a dynamic focussing system and prediction errors in the dynamic focus system are likely to be low when scanning subsequent swathes.

METHOD OF FORMING MASK PATTERN ON SUBSTRATE

PROBLEM TO BE SOLVED: To provide a method of forming a two-dimensional mask pattern on a substrate. SOLUTION: The method of forming the two-dimensional mask pattern on the substrate (1) comprises (a) printing a non-electrically conductive material (2) on the substrate in a coarse version of the required mask patterns (3A to 3D) and (b) selectively ablating a portion (3B) of the material using a laser to refine the coarse pattern to form the desired mask pattern. COPYRIGHT: (C)2005,JPO&NCIPI ...

Abtastgerät

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

METHOD AND DEVICE FOR SCANNING RADIAL BEAM

PROBLEM TO BE SOLVED: To provide a radial beam-scanning method which includes the compensation for the displacement of a reflected beam introduced by the reflector by changing a light path in a part with intervals on the circumference of the beam on the upstream side of the reflector in synchronization with the rotation of the reflector and starts scanning by the incidence of a beam on a rotary reflector. SOLUTION: A radial beam scanner includes a reflector 10 which can rotate so as to cause a scanning motion of an incident radial beam, and a compensating device 4 on which the radial beam falls before it reaches the rotary reflector 10. The compensating device 4 compensates the distortion of a reflected beam introduced by the reflector by changing a light path in a part with intervals on the circumference of the beam on the upstream side of the reflector in synchronization with the rotation of the reflector. COPYRIGHT: (C)1998,JPO ...

Forming a conductive pattern on a substrate

A method of forming a conductive pattern on a substrate. The method comprising providing a substrate carrying a conductive layer; forming a first portion of the conductive pattern by exposing the conductive layer to a laser and controlling the laser to remove conductive material around the edge(s) of desired conductive region(s) of the first portion; and laying down an etch resistant material on the conductive layer, the etch resistant material defining a second portion of the conductive pattern, removing conductive material from those areas of the second portion not covered by the etch resistant material, and then removing the etch resistant material.

Ink pinning assembly

METHOD AND APPARATUS FOR IMAGING A SAMPLE USING A MICROSCOPE SCANNER

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position. 1. A microscope scanning apparatus comprising:a detector array for obtaining an image from a sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array along a scan path; anda controller configured to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position while the sample holder is in motion, further comprising a drive assembly configured to move the sample holder relative to the detector array.2. A method for imaging a sample using a microscope scanner , the microscope scanner comprising:a detector array for obtaining an image from the sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array along a scan path; anda controller configured to monitor the position of the sample holder relative to the detector array, the method comprising:monitoring the position of the sample holder along the scan path; and triggering image capture by the detector array in accordance with the monitored position while the stage is in motion, further comprising modulating the exposure time of the detector array in accordance with the velocity of the sample holder relative to the detector array.3. A microscope scanning apparatus comprising: a drive assembly comprising a track; a detector array for obtaining an image from a sample; a sample holder coupled to the track and adapted to hold the sample ...

A METHOD OF PRINTING DIGITAL IMAGES

A method of printing using a print head comprising first and second print arrays, each comprising a plurality of nozzles. Each of the first print array nozzles emits a droplet of a first volume and each of the second print array nozzles emits a droplet of a second volume, wherein the first volume is less than the second volume. The method comprises: a. receiving image data comprising a received tone value for a pixel; b. selecting one of the print arrays corresponding to the pixel location; c. mapping the received tone value to a mapped tone value using a tone mapping for the selected print array; d. comparing the mapped tone value with a threshold value for the location of the pixel; and e. generating a control signal for the selected print array if the mapped tone value corresponds to the threshold value in a predetermined manner.

Ink pinning assembly

An ink pinning assembly comprises a source(3) of UV radiation suitable for pinning ink on a record medium. A radiation guide device(2) has an inlet(6) facing the source(3) and an outlet(10) through which radiation is emitted towards a record medium, in use, the length of the inlet(6) being greater that the length of the radiation source(3). The radiation guide device(2) has a substantially rectangular or square wall in plan surrounding a cavity(14) extending between the inlet(6) and outlet(10), the internal surface(9,11-13) of the wall being reflective to the pinning radiation so that pinningradiation with a substantial uniform intensity is emitted from the outlet.

Whole slide imaging method for microscope

A method for operating a microscope scanner (1) comprising a line scanner (3) is provided. Generating pre-scan data for a target (6) comprising the sample, wherein generating the pre-scan data comprises: obtaining a pre-scan image of the target (6) from the pre-scan; and identifying one or more sample-containing regions (24) and one or more sample-free regions (26) of the target (6) from the pre-scanned image. An imaging scan is then performed on a scan region of the target (6) comprising one or more sample-containing regions (24) and one or more sample-free regions (26). A scan speed of the line scanner (3) is adjusted along the image scan path based on the pre-scan data such that the target (6) is imaged within the one or more sample-free regions (26) at a higher scan speed than in the one or more sample-containing regions (24).

INKJET HEAD SUPPORT ASSEMBLY

An inkjet head support assembly comprises a plurality of spaced apart carrier members mounted for relative movement along an elongate path, each carrier member including laterally offset first and second coupling positions. In use alternate inkjet heads are coupled at each of their ends between first coupling positions or between second coupling positions respectively of successive pairs of carrier members. At least one coupling position of each carrier member includes an adjustment mechanism to enable parts of inkjet heads coupled to the respective coupling positions of the same carrier member to be relatively aligned in the elongate direction. 1. An inkjet head support assembly comprising a plurality of spaced apart carrier members mounted for relative movement along an elongate path , each carrier member including laterally offset first and second coupling positions whereby in use alternate inkjet heads are coupled at each of their ends between first coupling positions or between second coupling positions respectively of successive pairs of carrier members , at least one coupling position of each carrier member including an adjustment mechanism to enable parts of inkjet heads coupled to the respective coupling positions of the same carrier member to be relatively aligned in the elongate direction.2. An assembly according to claim 1 , wherein the adjustment mechanism is provided at only one of the coupling positions of each carrier member.3. An assembly according to claim 1 , wherein the adjustment mechanism comprises a cam arrangement whereby rotation of the cam arrangement causes relative movement in the elongate direction between an inkjet head fixing location and the carrier member.4. An assembly according to claim 1 , wherein the adjustment mechanism is provided by an elongate slot in the carrier member extending in the elongate direction.5. An assembly according to claim 1 , wherein the adjustment mechanism is adapted to cause movement of an inkjet head ...

Image viewing apparatus

Image viewing apparatus comprises a transparent platen on which an image to be scanned can be positioned. A scanning system support is movable alongside the platen. A light source illuminates the platen from the same side as the scanning system support. A light diffuser can be moved between a first position in which it is located between the light source and the platen whereby light from the light source is diffused across the platen, and a second position in which the light diffuser is positioned so as not to impede a scanning system on the support from viewing an image on the platen.

Method and apparatus for forming a multiple focus stack image

A method is provided of producing a multiple focus stack image of a target. The stack image has a plurality of images of the target, each image having a corresponding focal range or position. The method utilizes relative scanning movement between the target and an array of light detectors, the array being used to repeatedly receive image information as scan lines from the target during the scan. During the scan the relative focus between the target and the array is modified between the focal range or position of the respective images so as to obtain the images in the stack. Each image is thereby formed from the image information obtained at the respective focal range or position during the scan. Apparatus for performing the method is likewise provided.

METHOD OF PREPARING A STAGE FOR USE IN A SLIDE IMAGING APPARATUS

A method of preparing a stage for use in a slide imaging apparatus including positioning a stage in relation to a flat surface so that the flat surface is positioned in front of the top surfaces of slide support pin bases on the top surface of the stage. The method also includes injecting a fluid pin surfacing material configured to solidify into the hole of each slide support pin base so that at least some of the fluid pin surfacing material exits the hole at the top surface of the slide support pin bases and pushes up against the flat surface. The method also includes removing the flat surface so that a tip of solid pin surfacing material is formed on the top surface of each slide support pin base, thereby providing the stage with a plurality of slide support pins.

Image generation based on a plurality of overlapped swathes

A method of generating a digital representation of a portion of an object from sets of digital data defining the color content of individually stored, overlapping swathes of pixels of an image of the object portion. The method comprises: (a) selecting a portion of the object; (b) determining the swathes which contain pixels within the selected portion; (c) correlating adjacent ones of said swathes; (d) if necessary, adjusting the relative positions of the adjacent swathes in accordance with the results of the correlating step (c); and, (e) generating a digital representation of pixels of the selected portion from the correlated swathes.

METHOD OF FORMING CONDUCTIVE PATTERN ON SUBSTRATE

PROBLEM TO BE SOLVED: To form a high-resolution conductive pattern on a substrate at a high processing speed. SOLUTION: The substrate for supporting a conductive layer is provided, and the conductive layer is exposed to a laser to form a first part 3 of the conductive pattern. A conductive material around the edge of a desired conductive region of the first part is removed by controlling the laser. An etch resistant material 20 is arranged on the conductive layer. The etch resistant material defines a second part of the conductive pattern. The conductive material is removed from these regions of the second part not coated by the etch resistant material. Then the etch resistant material is removed to form the conductive pattern on the substrate. COPYRIGHT: (C)2007,JPO&INPIT ...

Method and apparatus for estimating an in-focus position

METHOD AND APPARATUS FOR IMAGE SCANNING

A method of estimating an in-focus level of a target in an image scanning apparatus is provided, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target. The method comprises obtaining at least one image scan line of the target using the first line scan detector, each at least one image scan line being obtained at a respective focus level; obtaining at least one focus scan line of the target using the second line scan detector, each at least one focus scan line being obtained at a respective focus level; calculating at least one focus parameter using at least the at least one focus scan line; and estimating a nominal in-focus level of the target using the calculated focus parameter(s). 1. A method of estimating an in-focus level of a target in an image scanning apparatus , wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target , the method comprising:obtaining at least one image scan line of the target using the first line scan detector, each at least one image scan line being obtained at a respective focus level;obtaining at least one focus scan line of the target using the second line scan detector, each at least one focus scan line being obtained at a respective focus level and wherein the focus level of the at least one image scan line is different from the focus level of the at least one focus scan line;calculating at least one focus parameter using at least the at least one focus scan line; and,estimating a nominal in-focus level of the target using the calculated focus parameter(s);wherein the image and focus scan lines are obtained from different positions in the target and wherein image information is ...

IMAGING MICROSCOPE SAMPLES

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.

METHOD AND APPARATUS FOR IMAGE SCANNING

A method of estimating an in-focus level of a target in an image scanning apparatus is provided, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target. The method comprises obtaining at least one image scan line of the target using the first line scan detector, each at least one image scan line being obtained at a respective focus level; obtaining at least one focus scan line of the target using the second line scan detector, each at least one focus scan line being obtained at a respective focus level; calculating at least one focus parameter using at least one focus scan line; and estimating a nominal in-focus level of the target using the calculated focus parameter(s).

METHOD AND APPARATUS FOR IMAGE SCANNING

A method of estimating an in-focus level of a target in an image scanning apparatus, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target, the second line scan detector comprising at least one focus shifting element such that each focus scan line is obtained at respective first and second focus levels, wherein the first focus level is different from the second focus level, the method comprising: obtaining at least one focus scan line of the target using the second line scan detector; obtaining at least one image scan line of the target using the first line scan detector, the image scan line being obtained at a respective third focus level; calculating at least one focus parameter using the at least one focus scan line; and estimating a nominal in-focus level of the target using the at least one focus parameter. 1. A method of estimating an in-focus level of a target in an image scanning apparatus , wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target , the second line scan detector comprising at least one focus shifting element such that each focus scan line is simultaneously obtained at respective first and second focus levels along the focus scan line , wherein the first focus level is different from the second focus level , the method comprising:obtaining at least one focus scan line of the target using the second line scan detector;obtaining at least one image scan line of the target using the first line scan detector, the image scan line being obtained at a respective third focus level;calculating at least one focus parameter using the at least one focus scan line; andestimating a nominal in-focus level of ...

IMAGE SCANNING APPARATUS AND METHOD

An image scanning apparatus comprises a time delay integration sensor for obtaining first image information from a target and a scan device for causing relative motion between the time delay integration sensor and the target. The image scanning apparatus is characterized by detector array for obtaining second image information from a target, wherein the first image information corresponds to a first portion of light received from the target and the second image information corresponds to a second portion of light received from the target.

Method of preparing a stage for use in a slide imaging apparatus

A method of preparing a stage for use in a slide imaging apparatus including positioning a stage in relation to a flat surface so that the flat surface is positioned in front of the top surfaces of slide support pin bases on the top surface of the stage. The method also includes injecting a fluid pin surfacing material configured to solidify into the hole of each slide support pin base so that at least some of the fluid pin surfacing material exits the hole at the top surface of the slide support pin bases and pushes up against the flat surface. The method also includes removing the flat surface so that a tip of solid pin surfacing material is formed on the top surface of each slide support pin base, thereby providing the stage with a plurality of slide support pins.

Image scanning apparatus and methods of operating an image scanning apparatus

Image scanning apparatus and method of operating an image scanning apparatus, the image scanning apparatus including a line scan detector and being configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction.

METHOD AND APPARATUS FOR IMAGING A SAMPLE USING A MICROSCOPE SCANNER

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position. 1. A microscope scanning apparatus comprising:a detector array for obtaining an image from a sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array along a scan path; anda controller configured to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position while the stage is in motion.2. The microscope scanning apparatus of claim 1 , further comprising a drive assembly configured to move the sample holder relative to the detector array.3. The microscope scanning apparatus of claim 2 , wherein the drive assembly is controlled by the controller.4. The microscope scanning apparatus of claim 1 , wherein said controller is further configured to modulate the exposure time of the detector array in accordance with the velocity of the sample holder relative to the detector array.5. The microscope scanning apparatus of claim 1 , further comprising a light source for illuminating the sample claim 1 , wherein said controller is further adapted to modulate the intensity of the light output by the light source in accordance with the velocity of the sample holder relative to the detector array.6. The microscope scanning apparatus of claim 1 , wherein the controller further comprises a filter module such that when in use a trigger rate does not exceed the maximum frame rate of the detector array.7. The microscope scanning apparatus of claim 1 , wherein the controller is ...

Method and apparatus for image scanning

A method of estimating an in-focus level of a target in an image scanning apparatus is provided, wherein the image scanning apparatus comprises a first line scan detector configured to obtain one or more image scan lines of the target and a second line scan detector configured to obtain one or more focus scan lines of the target. The method comprises obtaining at least one image scan line of the target using the first line scan detector, each at least one image scan line being obtained at a respective focus level; obtaining at least one focus scan line of the target using the second line scan detector, each at least one focus scan line being obtained at a respective focus level; calculating at least one focus parameter using at least the at least one focus scan line; and estimating a nominal in-focus level of the target using the calculated focus parameter(s).

Generating input profile data

A method of generating data representing an input profile defining a relationship between input color data generated by an input device and modified in accordance with a predetermined algorithm, and corresponding device independent data. The method comprises:a) operating the input device on a range of predetermined input colors to generate said input color data;b) processing said input color data in accordance with the predetermined algorithm to generate output data suitable for operating an output device;c) converting said output data to said device independent data; and,d) generating said input profile data such that application of said input profile to said input color data substantially generates said device independent data.

IMAGE OBSERVING DEVICE

PROBLEM TO BE SOLVED: To provide an image observing device having smaller-sized device constitution. SOLUTION: This image observing device is provided with a transparent platen 1 capable of placing an image to be scanned on it. A scan system support part 2 is made movable along the platen 1. Light sources 8, 9 illuminate the platen 1 from the same side as the scan system support part 2. A light duffusor 5 exists between the light source 8, 9 and the platen 1, and is made movable between the first position that light from the light source 8, 9 traverse the platen 1 to be diffused and the second position that the light diffusor 5 exists on the position where the observation of the image on the platen 1 is not impeded due to a scan system on the support part 2. COPYRIGHT: (C)1998,JPO ...

Inkjet head support assembly

An inkjet head support assembly comprises a plurality of spaced apart carrier members mounted for relative movement along an elongate path, each carrier member including laterally offset first and second coupling positions. In use alternate inkjet heads are coupled at each of their ends between first coupling positions or between second coupling positions respectively of successive pairs of carrier members. At least one coupling position of each carrier member includes an adjustment mechanism to enable parts of inkjet heads coupled to the respective coupling positions of the same carrier member to be relatively aligned in the elongate direction.

METHOD AND APPARATUS FOR IMAGING A SAMPLE USING A MICROSCOPE SCANNER

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals. 1. A microscope scanner comprising:a detector array for obtaining an image from a sample;a sample holder adapted to hold the sample when in use, the sample holder being configured to move relative to the detector array; anda controller configured to issue position control signals so as to control the relative position of the sample holder;wherein the sample holder is configured to continuously move to a plurality of target positions relative to the detector array during an imaging scan in accordance with the position control signals, and wherein said detector array is configured to capture images while the sample holder is in motion based on the position control signals issued during the imaging scan, wherein the plurality of target positions corresponds to a target velocity profile, and wherein the target velocity profile is stored on a memory accessible by the controller.2. A method for imaging a sample using a microscope scanner comprising a detector array for obtaining an image from the sample , a sample holder adapted to hold the sample when in use , said sample holder being configured to move relative to the detector array , and a controller configured to issue position control signals so as to control the position of the sample holder , the method comprising:issuing position control signals so as to move the sample holder to a plurality of target positions relative to the detector array during an imaging scan; andcapturing images of the sample using the detector array based on the position control signals ...

Method and apparatus for generating a bitmap

A method of generating a bitmap representative of an original image. The method comprises (1) scanning the original image to generate a greyscale pixel map; (2) interpolating and rotating the greyscale pixel map to generate a higher resolution greyscale pixel map; and (3) converting the higher resolution greyscale pixel map into the bitmap. The greyscale pixel map is converted into the bitmap by (I) ranking each greyscale pixel value against the greyscale pixel values of a neighborhood of adjacent pixel locations; (ii) determining a desired number of black binary pixels (B_Pc) in the neighborhood; (iii) comparing the rank of the greyscale pixel with the desired number of black binary pixels; and (iv) assigning a black binary pixel value to the pixel location when the comparison carried out in step (iii) satisfies a predetermined condition.

Sharpness enhancement

A method of enhancing the sharpness of spatial frequencies in a digital image obtained by a digital imaging system. The method comprising modifying digital data defining the pixel content of the image so as to replace the spatial frequency characteristics of the digital image due to the digital imaging system with spatial frequency characteristics of an image produced by a microscope.

PROCESSING A FLEXOGRAPHIC PRINTING PLATE

A method for processing a flexographic printing plate on which patterned flexographic material that is uncured or partially cured has been provided, the method comprising mechanically shaping the upper surface of the flexographic material and fully curing the shaped material.

PRODUCING A FLEXOGRAPHIC PRINTING PLATE

A method of producing a flexographic printing plate, comprises: a) inkjet printing a layer of flexographic material in a predetermined pattern onto a substrate; b) partially curing at least part of the printed layer of flexographic material so as to immobilize it on the substrate; and c) repeating steps (a) and (b) so as to print and partially cure one or more further layers of flexographic material in the predetermined pattern on the previous layer(s), characterized by additionally curing one or more lower printed layers before or while printing one or more upper layers so as to reduce spreading of the lower printed layer(s).

Ink pinning assembly

An ink pinning assembly comprises a source of UV radiation suitable for pinning ink on a record medium. A radiation guide device has an inlet facing the source and an outlet through which radiation is emitted towards a record medium, in use, the length of the inlet being greater that the length of the radiation source. The radiation guide device has a substantially rectangular or square wall in plan surrounding a cavity extending between the inlet and outlet, the internal surface of the wall being reflective to the pinning radiation so that pinning radiation with a substantial uniform intensity is emitted from the outlet.

Method and apparatus for estimating an in-focus position

A method is provided of estimating an in-focus position of a target in an image scanning apparatus. A first part of the target is scanned at a nominal focus level so as to obtain corresponding image information. One or more further parts of the target are scanned at one or more respective further focus levels so as to obtain corresponding image information. A focus parameter is then calculated for each of the nominal and the one or more further focus levels using the respective image information. An in-focus position common to each of the first and further parts of the target is then estimated using the calculated focus parameters. Corresponding apparatus for performing the method is also provided.

Method and apparatus for image scanning

A method of estimating an in-focus level of a target in an image scanning apparatus (100) is provided, wherein the image scanning apparatus comprises a first line scan detector (2) configured to obtain one or more image scan lines of the target and a second line scan detector (3) configured to obtain one or more focus scan lines of the target. The method comprises obtaining at least one image scan line of the target using the first line scan detector (2), each at least one image scan line being obtained at a respective focus level; obtaining at least one focus scan line of the target using the second line scan detector (3), each at least one focus scan line being obtained at a respective focus level; calculating at least one focus parameter using at least the at least one focus scan line; and estimating a nominal in-focus level of the target using the calculated focus parameter(s).

Method of determining an image recording device characterization

A method is provided of determining an image recording device characterisation for a target image. A number of component spectra are determined from a set of target spectra obtained from the target image such that the spectra can be represented by combinations of one or more of the component spectra. A perceptual color space data set is defined and combinations of the component spectra which correspond to the perceptual color space data set are determined. A device data set is generated in accordance with the determined combinations and a device spectra response, the device data set representing a set of colors which can be generated by an image recording device having the device spectral response. A characterisation is then determined by reference to the relationship between the device and perceptual color space data sets.

SLIT CONFOCAL MICROSCOPE AND ITS OPERATION METHOD

PROBLEM TO BE SOLVED: To prevent the lowering of the intensity of a video associated with the change of a focus. SOLUTION: A linear light source, a detection system and a condensing system condensing light from the light source on a sample and condensing returned light on the detection system are disposed in a slit confocal microscope. Furthermore, a one-dimensional linear detector array on which the light from the sample is directly and indirectly condensed by the condensing system, and a control system controlling the linear detector array to integrate light from a line corresponding to a pixels on the sample are disposed in the detection system. COPYRIGHT: (C)2006,JPO&NCIPI ...

METHOD FOR FORMING AN IMAGE REFERENCE DEVICE

A method is provided of forming an imaging reference device for a biological material imaging system. A first region is provided in a substrate formed from an optically transmissive material which is an analogue of biological tissue. This first region is stained using a first biological tissue stain. A second region is provided in second substrate which is optically transmissive and an analogue of biological tissue. The second region is stained with a second biological tissue stain. The first and second regions are overlapped as a pair, such that light incident upon the pair is modulated by the respective first and second biological tissue stains of the respective regions. Multiple regions of the first and second type may be provided, stained to different degrees. 1. A method of forming an imaging reference device for a biological material imaging system , the method comprising:providing at least one first region of a first substrate, the first substrate being formed from an optically transmissive material which is an analogue of biological tissue, wherein the at least one first region is stained using a first biological tissue stain;providing at least one second region of a second substrate, the second substrate being formed from an optically transmissive material which is an analogue of biological tissue, wherein the at least one second region is stained using a second biological tissue stain; and,overlapping at least one pair of the regions, each pair being formed from the overlap of a first region with a second region, such that light incident upon a pair is modulated by the respective first and second biological tissue stains of the respective regions.2. A method according to claim 1 , wherein a plurality of first regions is provided as a first series of first regions and wherein a plurality of second regions is provided as a second series of second regions.3. A method according to claim 2 , wherein in one or each of the first and second series claim 2 , the ...

METHOD OF PREPARING A STAGE FOR USE IN A SLIDE IMAGING APPARATUS

A method of preparing a stage for use in a slide imaging apparatus including positioning a stage in relation to a flat surface so that the flat surface is positioned in front of the top surfaces of slide support pin bases on the top surface of the stage. The method also includes injecting a fluid pin surfacing material configured to solidify into the hole of each slide support pin base so that at least some of the fluid pin surfacing material exits the hole at the top surface of the slide support pin bases and pushes up against the flat surface. The method also includes removing the flat surface so that a tip of solid pin surfacing material is formed on the top surface of each slide support pin base, thereby providing the stage with a plurality of slide support pins.

METHOD AND APPARATUS FOR ESTIMATING AN IN-FOCUS POSITION

A method for estimating an in-focus position of a target using an image scanning apparatus is provided. The in-focus position is monitored at a seed location and an end location on the target and a pre-scan path is calculated between these locations. A pre-scan is then performed and a focus parameter is monitored for a plurality of locations along the pre-scan path. An imaging scan is next performed wherein the target is imaged along an image scan path and a focus parameter is monitored for a plurality of locations along said path. The focal height of the apparatus is adjusted during the imaging scan by comparing the focal parameter monitored for a current location on the image scan path with the focal parameter monitored for a similar location on the pre-scan path. The focal parameter monitored for different locations on the image scan path may also be compared. 1. A method for estimating an in-focus position of a target using an image scanning apparatus comprising:a) monitoring an in-focus focal position of the target at each of, a seed location upon the target and an end location upon the target, wherein the end location is different from the seed location;b) conducting a pre-scan of the target along a pre-scan path, said pre-scan path comprising a plurality of locations on the target with respective focal positions calculated in accordance with the monitored focal positions at the seed and end locations, the pre-scan comprising monitoring a focus parameter at the plurality of locations and respective focal positions along the pre-scan path;c) conducting an imaging scan wherein the target is imaged along an image scan path comprising the said plurality of locations on the target and wherein during the imaging scan, at the locations along the image scan path, the focus parameter is monitored and compared with the respective pre-scan focus parameter for that location, and the focal position of the apparatus is modulated according to the following conditions:if the ...

Method of forming an imaging calibration device

A method of forming an imaging calibration device for a biological material imaging system, the method comprises: providing one or more discrete regions upon or within a retaining member, each region for the receipt of a selected predetermined biological stain material; selecting one or more predetermined biological stain materials, wherein each of the selected predetermined biological stain materials has a predetermined optical response, and providing one or more of the selected predetermined biological stain materials to the said one or more discrete regions such that the said material is localised in the said region.

IMAGE SCANNING APPARATUS AND METHODS OF OPERATING AN IMAGE SCANNING APPARATUS

Image scanning apparatus and method of operating an image scanning apparatus, the image scanning apparatus including a line scan detector and being configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction. 1. A method of operating an image scanning apparatus;wherein the image scanning apparatus includes a line scan detector and is configured to image a surface of an object mounted in the image scanning apparatus in a plurality of swathes, wherein each swathe is formed by a group of scan lines, each scan line being acquired using the scan line detector from a respective elongate region of the surface of the object extending in a scan width direction, wherein each group of scan lines is acquired whilst the object is moved relative to the scan line detector in a scan length direction;wherein the method includes:using at least one scan line, acquired from a surface of a first object mounted in the image scanning apparatus using the scan line detector, to obtain at least one measure indicating that the surface of the first object is uneven or tilted in the scan width direction relative to an imaging plane of the image scanning apparatus,setting a swathe width value for use in acquiring at least one swathe from a surface of a second object mounted in the image scanning apparatus, wherein the swathe width value is set based on the at least one measure and configured so as to keep each swathe acquired from the surface of the second object substantially in focus across its width in the scan width direction, andacquiring at least one swathe from the surface of the second object ...

Image observing device

(57)【要約】 【課題】 より小型の装置構成を有する画像観察装置を 提供すること。 【解決手段】 本発明の画像観察装置は、走査を行なう 画像を上に置くことができる透明プラテン（１）を備え る。走査システム支持部（２）は、プラテン（１）に沿 って移動可能である。光源（８、９）が走査システム支 持部（２）と同じ側からプラテン（１）を照らす。光拡 散器（５）は、光源とプラテンとの間にあって、光源か らの光がプラテンを横切って拡散される第１の位置と、 光拡散器が、支持部上の走査システムによる、プラテン 上の画像の観察を阻害しない位置にある第２の位置との 間で移動可能である。

Method of forming an imaging reference device

Slit confocal microscope and method

A slit confocal microscope comprises a linear light source (10); a detection system (13); and a focusing system (3) for focusing light from the source onto a sample and focusing returning light onto the detection system (13). The detection system (13) comprises a one-dimensional, linear array of detectors onto which light from the sample is focused directly or indirectly by the focusing system. A control system (14) causes the linear array of detectors to integrate light from a corresponding line of pixels in the sample.

Method and apparatus for estimating an in-focus position

A method for estimating an in-focus position of a target using an image scanning apparatus is provided. The in-focus position is monitored at a seed location and an end location on the target and a pre-scan path is calculated between these locations. A pre-scan is then performed and a focus parameter is monitored for a plurality of locations along the pre-scan path. An imaging scan is next performed wherein the target is imaged along an image scan path and a focus parameter is monitored for a plurality of locations along said path. The focal height of the apparatus is adjusted during the imaging scan by comparing the focal parameter monitored for a current location on the image scan path with the focal parameter monitored for a similar location on the pre-scan path. The focal parameter monitored for different locations on the image scan path may also be compared.

Producing a flexographic printing plate

A method of producing a flexographic printing plate, comprises: a) inkjet printing a layer of flexographic material in a predetermined pattern onto a substrate; b) partially curing at least part of the printed layer of flexographic material so as to immobilize it on the substrate; and c) repeating steps (a) and (b) so as to print and partially cure one or more further layers of flexographic material in the predetermined pattern on the previous layer(s), characterized by additionally curing one or more lower printed layers before or while printing one or more upper layers so as to reduce spreading of the lower printed layer(s).

Method and apparatus for forming a multiple focus stack image

A method of producing a multiple focus stack image of a target, the stack image comprising a plurality of images of the target, each image having a corresponding focal range or position, wherein the method comprises causing relative scanning movement between the target and an array of light detectors, the array being used to repeatedly receive image information from the target during the scan in the form of scan lines; and causing the relative focus between the target and the array to be modified between the said focal ranges or positions of the respective images during the scan so as to obtain scan lines corresponding to each focal range or position during the scan, thereby obtaining the images in the stack, wherein each image is formed from the image information obtained as scan lines at the respective focal range or position during the scan. The method is then further characterised in that the relative focus is cycled between two extreme focal ranges or positions during the relative scanning movement and at least one scan line is obtained at a focal range or position located between subsequent extreme focal ranges or positions during the scan, each scan line being used to form one of the images of the target

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

A whole slide imaging method for a microscope

A method is provided for operating a microscope scanner 1 comprising a line scanner 3. Pre-scan data is generated for a target 6 comprising a sample, wherein generating the pre-scan data comprises: obtaining a pre-scan image of the target 6 from a pre-scan; and identifying one or more sample-containing regions 24 and one or more sample-free regions 26 of the target 6 from the pre-scan image. An imaging scan is then performed of a scanning region of the target 6 including the one or more sample-containing regions 24 and the one or more sample-free regions 26. The scanning speed of the line scanner 3 is adjusted along the image scan path based on the pre-scan data so that the target 6 is imaged at a higher scanning speed within the one or more sample-free regions 26 than in the one or more sample-containing regions 24.

Image generation

A method of generating a digital representation of a portion of an object from sets of digital data defining the colour content of individually stored, overlapping swathes of pixels of an image of the object portion. The method comprises: (a) selecting a portion of the object; (b) determining the swathes which contain pixels within the selected portion; (c) correlating adjacent ones of said swathes; (d) if necessary, adjusting the relative positions of the adjacent swathes in accordance with the results of the correlating step (c); and, (e) generating a digital representation of pixels of the selected portion from the correlated swathes.

A method for analysing scanning efficacy

A method is provided for operating a microscope scanner. A first imaging scan is performed of one or more area(s) of interest, AOI, on a target including a sample. This involves moving a detector array relative to the target along an image scan path and acquiring an image of the target at each of a plurality of locations along the image scan path. Focus control data is generated during the imaging scan by calculating a focus merit value at each said location along the image scan path. The focal height of the detector array is then adjusted along the image scan path based on the focus merit values. The efficacy of the first imaging scan is analysed using the focus control data and a change to one or more scanning parameters from the first imaging scan is determined, for the performance of a second imaging scan, based on this analysis.

Ink pinning assembly

An ink pinning assembly comprises a source (3) of UV radiation suitable for pinning ink on a record medium. A radiation guide device (2) has an inlet (6) facing the source (3) and an outlet (10) through which radiation is emitted towards a record medium, in use, the length of the inlet (6) being greater that the length of the radiation source (3). The radiation guide device (2) has a substantially rectangular or square wall in plan surrounding a cavity (14) extending between the inlet (6) and outlet (10), the internal surface (9,11-13) of the wall being reflective to the pinning radiation so that pinning radiation with a substantial uniform intensity is emitted from the outlet.

Method of forming an imaging calibration device

A method of forming an imaging calibration device for a biological material imaging system, the method comprising: providing one or more discrete regions (8) upon or within a retaining member (5), each region for the receipt of a selected predetermined biological stain material; selecting one or more predetermined biological stain materials, wherein each of the selected predetermined biological stain materials has a predetermined optical response, and providing one or more of the selected predetermined biological stain materials to the said one or more discrete regions such that the said material is localised in the said region.

Imaging calibration device for a biological material imaging device and method for forming said imaging calibration device

Method of forming an imaging calibration device

A method of forming an imaging calibration device for a biological material imaging system is provided. A first set of one or more discrete regions is provided upon or within a retaining member. Each said region of the first set comprises a selected tissue stain material, wherein each of the selected tissue stain materials exhibits a predetermined optical response inside a colour-stable region of a chromaticity diagram defined by the ellipse x2/a2+y2/b2=1, where a=0.21, b=0.135, the rotation is −0.07 rad and the translation is (0.38,0.333). A second set of one or more discrete regions is also provided upon or within the retaining member. The second set is formed of one or more coloured filters having a predetermined optical response outside the colour-stable region.

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanner is provided comprising a detector array for obtaining an image from a sample and a sample holder configured to move relative to the detector array. The sample holder can be configured to move to a plurality of target positions relative to the detector array in accordance with position control signals issued by a controller and the detector array is configured to capture images during an imaging scan based on the position control signals.

A method of printing digital images

A method of producing a printed output on a substrate using print head is provided. The print head comprises first and second print arrays, wherein the first and second print arrays each comprise a plurality of nozzles. Each of the nozzles of the first print array is configured to emit a droplet of a first volume and each of the nozzles of the second print array is configured to emit a droplet of a second volume, wherein the first volume is less than the second volume. The method comprises the steps of: a. receiving image data comprising a received tone value for a pixel within an image to be printed; b. selecting one of the print arrays of the first and second print arrays comprising a nozzle corresponding to the location of the pixel within the image to be printed, wherein each nozzle of the first and second print array is arranged to print a different respective pixel in the image data; c. mapping the received tone value to a mapped tone value using a tone mapping corresponding to the selected first or second print array, wherein the tone mapping corresponding to the first print array is different from the tone mapping corresponding to the second print array; d. performing the screening operation by comparing the mapped tone value with a threshold value for the location of the pixel within the image to be printed; and e. generating a control signal for the selected print array if the mapped tone value corresponds to the threshold value in a predetermined manner.

放射ビームを走査する方法および放射ビーム走査装置

(57)【要約】 【課題】 反射器の上側のビームの円周上に間隔のおか れた部分の光路を、反射器の回転の動きと同期して変更 し、それによって反射器によって導入された反射ビーム のずれを補うことを含む、ビームが回転反射器上に当り 走査動作を起こす放射ビームを走査する方法を提供す る。 【解決手段】 放射ビーム走査装置は、入射放射ビーム が走査動作を行なうようにさせるための回転可能な反射 器（１０）と、回転反射器に到達する前に放射ビームが その上に当たる補償装置（４）とを含む。補償装置は、 反射器の上流側のビームの円周上に間隔のおかれた部分 の光路を、反射器の回転の動きに同期して変更し、それ によって反射器によって導入された反射ビームの歪みを 補う。

撮像校正装置を形成する方法

【課題】生体物質撮像システムのための撮像校正装置を形成する方法を提供する。【解決手段】保持部材上又は保持部材内に１又は２以上の不連続領域の第１の組を提供する。第１の組の各領域は選択された組織染色材料を含み、選択された組織染色材料の各々は、楕円ｘ2／ａ2＋ｙ2／ｂ2＝１によって定められる色度図の色安定領域内の所定の光応答を示し、ここでａ＝０．２１、ｂ＝０．１３５であり、回転は－０．０７ｒａｄであり、変換は（０．３８，０．３３３）である。保持部材上又は保持部材内に１又は２以上の不連続領域の第２の組も提供する。第２の組は、色安定領域外の所定の光応答を有する１又は２以上の着色フィルタで形成される。【選択図】図７

Method of forming an imaging calibration device

A biological material imaging calibration device and method of forming such. A first set of discrete regions are provided upon a retaining member, each region containing a selected tissue stain material, which exhibits a predetermined optical response inside a colour-stable region of a chromaticity diagram, and providing a second set of discrete regions formed of coloured filters having predetermined optical responses outside the colour stable region. The selected tissue stain material may produce stable results over a year or 100 calibrations. Region of the first set may comprise an absorbent material stained with a respective material. The first set of regions may be provided by staining biopolymer films. The first set of regions may be provided by machining or casting recess areas. The first set of regions may be provided by a masking element with cut out regions. The first set of regions may be provided by printing the tissue stain materials onto a surface. Stain materials in different regions may have different concentrations. Providing the first set of regions may comprise spin coating the retainer with tissue stain materials. Providing the first set of regions may comprise depositing a thin film onto the retainer.

原稿画像を表わすビットマップを生成するための方法および装置ならびに複数の色分離から出力画像を生成するための方法および装置

(57)【要約】 【課題】 原稿画像を表わすビットマップの生成方法お よび装置を提供する。 【解決手段】 グレースケール画素マップ生成のため原 稿画像を走査するステップ（４０）と、より高解像度の グレースケール画素マップ生成のためグレースケール画 素マップを内挿および回転させるステップ（４４）と、 より高解像度のグレースケール画素マップをビットマッ プに変換するステップ（４５）とを含む方法である。 （ｉ）各グレースケール画素値を隣接する画素位置の近 傍のグレースケール画素値に対しランク付け（１０ ４）、（ｉｉ）近傍の黒２値画素の所望の数（Ｂ＿Ｐ ｃ）を決定し（１０６）、（ｉｉｉ）グレースケール画 素のランクと黒２値画素の所望の数とを比較し（１０ ８、１１０）、（ｉｖ）（ｉｉｉ）の比較が予め定めら れた条件を満たしているとき黒２値画素値を画素位置に 割当てる（１０９）ことで、グレースケール画素マップ はビットマップに変換される。

Verfahren zum bilden einer bildgebungskalibriervorrichtung

Es wird ein Verfahren zum Bilden einer Bildgebungskalibriervorrichtung für ein Bildgebungssystem für biologisches Material bereitgestellt. Ein erster Satz aus einem oder mehreren diskreten Bereichen ist auf oder in einem Halteelement vorgesehen. Jeder Bereich des ersten Satzes weist ein ausgewähltes Gewebefärbemittelmaterial auf, wobei jedes der ausgewählten Gewebefärbemittelmaterialien eine vorbestimmte optische Antwort innerhalb eines farbstabilen Bereichs eines Chromatizitätsdiagramms zeigt, das durch die Ellipse x2/a2+ y2/b2= 1 definiert ist, wobei a = 0,21, b = 0,135, die Rotation -0,07 rad und die Translation (0,38,0,333) ist. Ein zweiter Satz aus einem oder mehreren diskreten Bereichen ist ebenfalls auf oder im Halteelement vorgesehen. Der zweite Satz besteht aus einem oder mehreren Farbfiltern mit einer vorbestimmten optischen Antwort außerhalb des farbstabilen Bereichs.

Method and apparatus for estimating an in-focus position

A whole slide imaging method for a microscope

A method is provided for operating a microscope scanner (1) comprising a line scanner (3). Pre-scan data is generated for a target (6) comprising a sample, wherein generating the pre-scan data comprises: obtaining a pre-scan image of the target (6) from a pre-scan; and identifying one or more sample-containing regions (24) and one or more sample-free regions (26) of the target (6) from the pre-scan image. An imaging scan is then performed of a scanning region of the target (6) including the one or more sample-containing regions (24) and the one or more sample-free regions (26). The scanning speed of the line scanner (3) is adjusted along the image scan path based on the pre-scan data so that the target (6) is imaged at a higher scanning speed within the one or more sample-free regions (26) than in the one or more sample-containing regions (24).

A whole slide imaging method for a microscope

A method is provided for operating a microscope scanner (1) comprising a line scanner (3). Pre-scan data is generated for a target (6) comprising a sample, wherein generating the pre-scan data comprises: obtaining a pre-scan image of the target (6) from a pre-scan; and identifying one or more sample-containing regions (24) and one or more sample-free regions (26) of the target (6) from the pre-scan image. An imaging scan is then performed of a scanning region of the target (6) including the one or more sample-containing regions (24) and the one or more sample-free regions (26). The scanning speed of the line scanner (3) is adjusted along the image scan path based on the pre-scan data so that the target (6) is imaged at a higher scanning speed within the one or more sample-free regions (26) than in the one or more sample-containing regions (24).

Method and apparatus for imaging a sample using a microscope scanner

A microscope scanning apparatus is provided comprising a detector array for obtaining an image from a sample and a sample holder adapted to hold the sample when in use and to move relative to the detector array along a scan path. A controller is further provided to monitor the position of the sample holder relative to the detector array and to trigger image capture by the detector array in accordance with said monitored position.