THERMALLY CONDUCTIVE ONE IMPROVED CARBON SHEET BASIS ON MIXTURE CARBON MATERIAL FROM EXPANDED GRAPHITIC POWDER AND CARBON NANO-TUBULAR POWDER

PROCEDURE FOR THE PRODUCTION OF ESTER CONNECTIONS OF PYRETHROIDTYP.

DISPLAY DEVICE HAS Liquid crystals

Un dispositif d'affichage à cristaux liquides comprend : un panneau à cristaux liquides (106) ; une pluralité de lampes (120) pour rayonner une lumière sur le panneau à cristaux liquides ; un capot inférieur (114) pour loger les lampes (120) ; et un onduleur (130) monté sur la surface arrière du capot inférieur, et comprenant un transformateur (134) et une pluralité de composants passifs et générant un signal de commande de lampes pour commander les lampes. Un espace évidé (115) est formé parallèlement aux lampes sur le côté long de l'extrémité inférieure de la surface arrière du capot inférieur, l'onduleur (130) est monté en correspondance avec l'espace évidé (115), et le transformateur est positionné dans l'espace évidé (115) tout en maintenant la même distance par rapport aux extrémités gauche et droite des lampes. Le dispositif d'affichage à cristaux liquides présente une épaisseur réduite et permet de maintenir l'équilibre gauche-droite du courant délivré aux lampes.

HYGENIC PAPER CONTAINER

SHOWER HEAD ULTRA-THIN TWO-SIDED

ROTARY JET DEVICE AND SYSTEM WITH DIFFERENT JET

WATER SPRAYER ANNULAR PARTICLE AND SHOWER HEAD

Un dispositif de projection d'eau à particules annulaires comprend le corps du dispositif (1) et le corps de noyau (2), un trou de passage creux compris dans ledit corps du dispositif, et il existe une structure de projection d'eau destinée à former le jet d'eau annulaire dans ledit corps de noyau, ladite structure de projection d'eau se situe dans le trou de passage creux du corps du dispositif ; ledit trou de passage creux du corps a une paroi de retour dont le diamètre diminue de haut en bas, ladite paroi de retour se situe sous la structure de projection d'eau ; le fond du trou de passage creux constitue un trou de projection d'eau qui se situe sous la paroi de retour. L'invention peut former un cercle des eaux projetées avec un certain angle de projection qui est formé d'abord en voile de pluie puis est dispersé en nombreuses particules fines, ces eaux projetées sont fines avec le sentiment de contact, plus naturellement avec le choc visuel, permettant aux utilisateurs de sentir l'intimité ...

A CYCLOSPORIN CONTAINING PREPARATION AND A PROCEDURE FOR YOUR PRODUCTION

SHOWER WITH UNIDIRECTIONAL FILTER

Une pomme de douche à filtration unidirectionnelle, comprenant un corps de pomme de douche, un ensemble de filtration unidirectionnelle, une unité de passage d'eau unidirectionnel (22), un support de filtre (23) et un premier filet de filtre (24) ; pomme dans laquelle l'unité de passage d'eau unidirectionnel (22) est agencée dans le siège de passage d'eau (21) ; le support de filtre (23) est raccordé de façon détachable ; le support de filtre (23) est pourvu d'un trou de passage d'eau (231); l'unité de passage d'eau unidirectionnel (22) comprend une bague en forme de V (221) et un cadre de passage d'eau (222) ; une portion de déformation de la bague en forme de V (221) appuie sur une paroi interne du siège de passage d'eau (21), et une direction de déformation de la bague en forme de V (221) est identique à la direction de passage d'eau.

PROCEDURE AND DEVICE FOR THE PRODUCTION OF A LIMITING RECTANGLE OF A VIDEO OBJECT SURFACE FOR INTERMEDIATELINESCANNED VIDEO SIGNALS

METHOD AND SYSTEM FOR IDENTIFYING MATERIAL USING BINOCULAR IMAGES OF STEREOSCOPIC AND BY DISCRETE MULTIPLE ENERGY

DISPLAY DEVICE HAS Liquid crystals

AN ELECTROMAGNETIC VALVE HAS PULSE WIDTH MODULATION TO CONTROL THE DIRECTION OF FLOW OF A FLUID AND SHOWER HEAD INCORPORATING SAME

Un dispositif de valve comprend un siège de valve (2) fixé à un capuchon (1) pour former un premier orifice de sortie (21), un second orifice de sortie (22), et un orifice d'entrée ; une tige mobile (4) dans une chambre entre les premier et second orifices (21, 22) ; une valve électromagnétique (3) adjacente au premier orifice (21) ; et un chenal (23) entre la tige (4) et la valve (3). Dans une première opération, la valve (3) ouvre le premier orifice (21) et ferme le second orifice (22) de sorte que l'eau s'écoule depuis l'orifice d'entrée (20) vers le premier orifice (21) via la chambre (24) et le chenal (23). Dans une seconde opération la valve (3) ferme le premier orifice (21) et ouvre le second orifice (22) de sorte que l'eau s'écoule depuis l'orifice d'entrée (20) vers le second orifice (22) via la chambre (24).

ENCAPSULATING SETTING LIQUID COMPOSITE ELECTROLUMINESCENT DIODE

Il est fourni un composite de polysiloxane/TiO2 liquide durcissable pour une utilisation comme encapsulant de diode électroluminescente comprenant : un polysiloxane avec des domaines de TiO2 présentant une taille moyenne de domaine inférieure à 5 nm, dans lequel le composite de polysiloxane/TiO2 liquide durcissable contient de 20 à 60 % en mole de TiO2 (rapporté au total des matières solides) ; dans lequel le composite de polysiloxane/TiO2 liquide durcissable présente un indice de réfraction > 1,61 à 1,7 et dans lequel le composite de polysiloxane/TiO2 liquide durcissable est un liquide à température ambiante et à pression atmosphérique. Il est également fourni un ensemble de fabrication de diode électroluminescente.

ATTACHMENT STRUCTURE HAS AN AIRCRAFT LUXURIATING AND CONTROL BOX

Une structure de fixation (100) à démontage et montage aisés, qui est destinée à fixer un élément à fixer à un appareil fixe, comprenant un siège de fixation pour supporter un élément à fixer au moins une attache de fixation souple raccordée de manière mobile au siège de fixation, dans laquelle, en cours d'utilisation, l'au moins une attache de fixation souple s'enroule autour de l'appareil et est bloquée de manière détachable à l'appareil fixe, ce qui a pour effet de fixer le siège de fixation à l'appareil fixe.

SHOWER SWITCHABLE TACTILE

Une douche commutable de manière tactile, qui inclut un corps de douche, un ensemble de commutation, une couche de revêtement conducteur, un ensemble de commande, et une électrovanne commandée par impulsions. L'ensemble de commutation est agencé à l'intérieur du corps de douche, et un trajet d'arrivée d'eau (11) et deux trajets de sortie d'eau sont prévus. La couche de revêtement conducteur est déposée sur une surface extérieure du corps de douche pour fournir en sortie un signal de détection tactile. L'ensemble de commande inclut une unité de rectification (41), une unité de commande tactile (42), une unité de commande de vanne (43), et une unité de commande principale (44). L'unité de rectification (41) est configurée pour convertir un courant alternatif en un courant continu fourni à l'unité de commande principale (44), à l'unité de commande de vanne (43), et à l'unité de commande tactile (42) reliées électriquement à celle-ci.

SHOWER HEAD ULTRA-THIN TWO-SIDED

Une pomme de douche ultramince à deux côtés comprend un corps de préhension (1), une coque de logement (2a), un couvercle (2) et un mécanisme de commutation (3). Le corps de préhension (1) a une partie de sortie (11). Le couvercle (2) est adapté sur la coque de logement (2a) et deux chambres d'eau sont définies entre eux. Le mécanisme de commutation (3) comprend un ensemble de direction d'eau (31), un élément mobile à coulissement (32) et un élément de commande (33), il est monté rotatif sur ladite partie de sortie (11) et définit un espace interne se divisant en deux trous séparés reliés auxdites chambres. L'élément de commande (33) est couplé à ladite partie de sortie (11) et peut commander l'élément mobile à coulissement (32) pour qu'il se déplace le long de l'ensemble de direction d'eau (31) grâce à une structure de commande à excentrique (4).

TARPAULIN RENFORCEE WITH BITS IN UHMWP

METHODS AND SYSTEMS FOR SIMULATING FLUID FLOW NETWORK EMPLOYING TWO-PHASE ENVELOPES WITH INTERPOLATED VALUES

Un procédé (700) comprend la modélisation (702) d'un réseau d'écoulement de fluide, le réseau d'écoulement de fluide ayant un réseau de canalisations en surface (106) raccordé entre une pluralité de nœuds (N1, N2) de perforation de puits (W2-W26) et une sortie ou entrée commune. Le procédé (700) comprend également la génération (704) d'une pluralité d'enveloppes à deux phases (200) pour le réseau d'écoulement de fluide modélisé, chaque enveloppe à deux phases (200) ayant au moins certaines valeurs interpolées et correspondant à une section du réseau d'écoulement de fluide modélisé avec une composition d'écoulement constante. Le procédé (700) comprend également la détermination (706) d'informations d'équilibre de phase pour le réseau d'écoulement de fluide modélisé sur la base des enveloppes à deux phases générées (200). Le procédé (700) comprend également l'application (708) des informations d'équilibre de phase déterminées à des opérations de production ou de simulation associées au réseau ...

TARPAULIN HAVING BITS OF REINFORCEMENT OF CHAÏNE AND SCREEN.

A MOVABLE GANTRY SYSTEM, FOR INSPECTION OF CONTAINERS

Selon l'invention, ledit système comporte un cadre de balayage cantilever (2) pouvant se déplacer sur des rails (7) autour d'un conteneur (4) et comportant une source de rayonnement (1) et des détecteurs (5).

WATER SPRAYER ANNULAR PARTICLE AND SHOWER HEAD

Laminated canvas comprises reinforced outer layers made of reinforcing material sandwiched and glued together, where the reinforcing material comprises first, second, third and fourth layer of parallel strands

Une toile à voile stratifiée renforcée ayant des propriétés d'étirement directionnel améliorées comporte des couches externes avec un matériau de renfort pris en sandwich et collé entre elles. Le matériau de renfort comprend des première, deuxième, troisième et quatrième couches de brins substantiellement parallèles. Les brins des première et deuxième couches s'étendent parallèlement et transversalement, respectivement, à un axe longitudinal des couches externes de matériau et sont non-tissés et non-tricotés . Les brins des troisième et quatrième couches s'étendent obliquement par rapport à ceux des première et deuxième couches, étant alignés suivant des premier et deuxième angles aigus respectivement par rapport à l'axe longitudinal. La toile à voile est fabriquée par un procédé continu dans lequel les brins qui forment les couches sont introduits indépendamment mais substantiellement simultanément. L'invention divulgue en outre une toile à voile stratifiée renforcée par des fils composés ...

METHODS AND SYSTEMS FOR SIMULATING FLUID FLOW NETWORK EMPLOYING TWO-PHASE ENVELOPES WITH INTERPOLATED VALUES

GENERATOR WITH PRESSURE, SIGNAL TRANSMITTER FOR REMOTE CONTROL, REMOTE CONTROL DEVICE AND SHOWER UNIT WITH PRESSURE GENERATOR

La présente invention concerne un générateur à pression, un émetteur de signal de commande à distance, un dispositif de commande à distance et une douche équipée du générateur. Le générateur à pression comprend un corps de générateur et une unité d'entraînement, l'unité d'entraînement comprenant un bouton et une partie de transmission, la partie de transmission étant configurée pour convertir un mouvement de pression du bouton en un mouvement de coupe de lignes d'induction magnétique par une bobine dans le corps du générateur. Ce générateur à pression permet de fournir davantage de puissance.

MANUFACTORING PROCESS OF ELECTROLUMINESCENT DIODE

Il est mis à disposition un procédé pour produire une diode électroluminescente (DEL) ayant un élément optique, comprenant les étapes consistant à : disposer d'un composite durcissable liquide de polysiloxane/TiO2, ayant un indice de réfraction de plus de 1,61 à 1,7, et qui est un liquide à la température ambiante et sous la pression atmosphérique ; disposer d'une matrice de diode électroluminescente à semi-conducteur ayant une face, laquelle matrice de diode électro-luminescente à semi-conducteur émet une lumière à travers la face ; mettre en contact la matrice de diode électroluminescente à semi-conducteur avec le composite durcissable liquide de polysiloxane/TiO2 ; et durcir le composite durcissable liquide de polysiloxane/TiO2 pour former un élément optique ; dans lequel au moins une portion de l'élément optique est adjacente à la face.

AN ELECTROMAGNETIC VALVE HAS PULSE WIDTH MODULATION TO CONTROL THE DIRECTION OF FLOW OF A FLUID AND SHOWER HEAD INCORPORATING SAME

ROTARY JET DEVICE AND DIFFERENT JET SYSTEM

Cette invention concerne un mécanisme de jet rotatif ainsi qu'un système à jets différents. Le mécanisme de jet rotatif comprend une partie fixe, un système d'entraînement, des unités coulissantes ainsi que plusieurs buses de sortie, lesdites buses de sortie étant amovibles et pouvant être détachées de la partie fixe, ladite unité coulissante peut glisser vis-à-vis de la partie fixe. Le système d'entraînement est actionné par l'effet hydraulique, son mécanisme d'entraînement doit être relié aux unités coulissantes à travers la transmission afin d'entraîner et faire glisser les unités coulissantes, les deux unités coulissantes sont connectées aux buses de sortie, afin que lesdites buses de sortie tournent autour d'un axe longitudinal avec l'axe desdites buses de sortie incliné par rapport audit axe longitudinal. Le système à jets différents comprend également un mécanisme de commande, Il est compact et fin avec une structure délicate, une buse de sortie peut sortir l'eau à différents jets ...

TARPAULIN RENFORCEE WITH BITS IN UHMWP

Une toile à voile stratifiée renforcée ayant des propriétés d'étirement directionnel améliorées comporte des couches externes avec un matériau de renfort pris en sandwich et collé entre elles. Le matériau de renfort comprend des première, deuxième, troisième et quatrième couches de brins substantiellement parallèles. Les brins des première et deuxième couches s'étendent parallèlement et transversalement, respectivement, à un axe longitudinal des couches externes de matériau et sont non-tissés et non-tricotés . Les brins des troisième et quatrième couches s'étendent obliquement par rapport à ceux des première et deuxième couches, étant alignés suivant des premier et deuxième angles aigus respectivement par rapport à l'axe longitudinal. La toile à voile est fabriquée par un procédé continu dans lequel les brins qui forment les couches sont introduits indépendamment mais substantiellement simultanément. L'invention divulgue en outre une toile à voile stratifiée renforcée par des fils composés ...

SHOWER SWITCHABLE TACTILE

PROCESS AND SYSTEM Of MATTER IDENTIFICATION USING STEREOSCOPIC BINOCULAR IMAGES AND BY TRANSMISSION MULTI-INERGIE.

Procédé et système d'identification de matière à l'aide d'une image binoculaire stéréoscopique et multi-énergie par transmission. Avec le procédé, tout obstacle qui domine l'absorption de rayons peut être décollé des objets qui se recouvrent dans la direction d'un faisceau de rayons. L'objet qui n'est pas visible en raison d'une absorption relativement faible de rayons est ainsi mis en évidence, et la nature de la matière de l'objet, notamment organique, mixte, métallique ou autre, peut être identifiée. Ce procédé constitue une base pour l'identification automatique d'objets dangereux tels que des explosifs, des drogues, etc., dissimulés dans un conteneur de fret.

Compuesto 3-({4-(2,2-difluoroetil)-3-(1h-pirrolo [2,3-b] piridin-5-il)-1h-pirazol-4-il] pirimidin-2-il}amino)propanonitrilo, inhibidor de raf; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del crecimiento celular anormal o cualquier enfermedad o afeccion mediada por raf.

Compuestos derivados de pirazol, composición farmacéutica que comprende a dicho compuesto y uso del compuesto para el tratamiento del crecimiento celular anormal.

Ringförmiger Reduktionsmittelmischer

Ein Motorabgas-Nachbehandlungssystem mit einem Ring, angeordnet in einer Abgasleitung und der Ring unterstützt bei der Einführung und Umwandlung eines Reduktionsmittels eingeführt durch einen Injektor.

Befestigungsvorrichtung für ein Emissionssystem mit Reduktionsmittelbeimischung

Es ist ein Emissionssteuerungssystem (16) offenbart. Das Emissionssteuerungssystem kann eine erste Abgasbehandlungsvorrichtung (36) aufweisen. Das Emissionssteuerungssystem kann ebenfalls eine Abschlusskappe (64) enthalten, die eine mit einem Ende der ersten Abgasbehandlungsvorrichtung verbundene Mischkammer (66) definiert. Die Mischkammer kann dazu ausgebildet sein, ein Vermischen eines von der ersten Abgasvorrichtung erhaltenen Abgasstroms und eines Reduktionsmittels zu fördern. Das Emissionssteuerungssystem kann weiterhin eine zweite Abgasbehandlungsvorrichtung (40) aufweisen, die dazu ausgebildet ist, den Strom aus Abgas und Reduktionsmittel zu erhalten, nachdem dieser die Mischkammer durchströmt hat.

Balun transformer

New compound separated from safflower, its preparation method and medical use

A novel compound extracted from safflower, its application in preparing medicines for treating ischemic cardiovascular and cerebrovascular diseases, and its composite medicines are disclosed.

Novel compounds that are erk inhibitors

Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).

Cardholder verification rule applied in payment-enabled mobile telephone

A method includes a cardholder device receiving at least one cardholder verification rule from a computer, and storing the cardholder verification rule. The cardholder verification rule prescribes circumstances under which a cardholder is required to perform a cardholder verification process in connection with a purchase transaction. The method includes the cardholder device receiving purchase transaction information from a merchant device, and then determining by using the stored cardholder verification rule, and based on at least one of the received purchase transaction information and current circumstances, that cardholder verification is not required. The cardholder device then uploads payment information to the merchant device to complete the purchase transaction.

Induced polymer assemblies

The invention provides compositions and methods for inducing and enhancing order and nanostructures in block copolymers and surfactants by certain nonpolymeric additives, such as nanoparticles having an inorganic core and organic functional groups capable of hydrogen bonding. Various compositions having lattice order and nanostructures have been made from a variety of copolymers or surfactants that are mixed with nonpolymeric additives. Particularly, a variety of nanoparticles with an inorganic core and organic functional groups have been discovered to be effective in introducing or enhancing the degree of orders and nanostructures in diverse block copolymers and surfactants.

Apparatus for Horologe with Removable and Interchangeable Face

The present invention discloses a horologe, such as a watch or clock, in which a removable and interchangeable face can be inserted and removed from the horologe and replaced with another face without disconnecting components of the horologe or interfering with the horologe measuring time. In one embodiment, the horologe comprises a horological movement; a housing having a rim and a mount plate, a removable face for insertion into a faceplate compartment, and an inner transparent cover. A portion of the rim may be extendable away from the housing to reveal an opening to receive a removable face. In one embodiment, the horologe may comprise an extendable drawer, which is adapted for insertion into and selectably extendable from the faceplate compartment. In one embodiment, the horologe may comprise an outer bezel, which has open and closed positions for revealing and covering the opening of the faceplate compartment.

Compositions and methods for delivery of biomacromolecule agents

The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Active cooling of cold-spray nozzles

Various embodiments disclosed relate to a method of cold-spray deposition involving cooling the cold-spray nozzle by at least one of expanding and vaporizing a compressed cooling fluid in proximity to the cold-spray nozzle. The present disclosure also includes a cold-spray deposition spray head, a cooling jacket for a cold-spray deposition nozzle and a cold-spray deposition system comprising the same.

Gas Engine Fast Start Fuel Strategy

A priming system for an engine system having a throttle valve configured to regulate a flow of air and fuel into an intake manifold of an engine is disclosed. The priming system may include a first sensor configured to generate a first sensor signal indicative of a value of an engine parameter, an auxiliary fuel line configured to direct fuel from a fuel source to a primed cylinder subset of the plurality of cylinders, an auxiliary fuel valve disposed in the auxiliary fuel line, and a controller in communication with the first sensor and the auxiliary fuel valve. The controller may be configured determine the value of the engine parameter from the first sensor signal and cease directing fuel from the auxiliary fuel line to the primed cylinder subset when the engine parameter value is greater than or equal to a threshold engine parameter value.

Medical articulation devices and methods of using the same

A medical device that includes a handle, a shaft extending distally from the handle, an end effector extending distally from the shaft, a first actuator movably coupled to the handle, and a second actuator movably coupled to the handle. The first actuator is configured to (1) articulate the shaft in response to translating the first actuator in a first direction relative to the handle and the second actuator, and (2) actuate the end effector in response to translating the first actuator in a second direction relative to the handle and the second actuator. The second actuator is configured to (1) articulate the shaft in response to translating the second actuator in the first direction relative to the handle and the first actuator, and (2) actuate the end effector in response to translating the second actuator in the second direction relative to the handle and the first actuator.

Vesicle-encapsulated socs

Provided herein are synthetic vesicles carrying a payload of one or more suppressors of cytokine signaling (SOCS) proteins. In particular, liposomes encapsulating SOCS1 and/or SOCS3, and methods of delivery and use for the treatment of lung disease and conditions, are provided.

Resource distribution hub generation on a mobile device

Embodiments of the present invention provide systems, apparatus, methods and/or the like for generating a resource distribution hub using for fully electronic resource distribution by using mobile device application designed to interface with an embedded Near-Field Communication (NFC) tag in a resource distribution instrument that stores instructions for processing the resource distribution authorization information. The holder (i.e., resource provider) of the resource distribution instrument can use the resource distribution instrument to communicate to a mobile communication device having an NFC reader to read the instructions and process a resource distribution according to the parameters of the mobile device application. As such, the holder (i.e., resource provider) of the resource distribution request can process the resource distribution without having to issue a credentials, aliases, pin codes, and the like conventionally used to authorizes the distribution of resources to the resource requester.

Compositions and methods for treatment of erectile disfunction

The subject invention pertains to methods and compositions for the treatment of erectile dysfunction (ED) (e.g., impotence) in a subject in need thereof utilizing one or more cannabinoid and one or more anti-ED drug.

Pyrazole carboxamide compounds and methods of use

Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Drinking containers

A disposable child's drinking cup has a lid with a drinking spout defining multiple open holes sized to resist leakage in the absence of suction, such as by the development of surface tension at the holes, and to allow flow when suction is applied. The holes are formed during molding of the lid. An inner contour of a groove of the lid and an outer contour of the cup body rim are selected to provide a slight snap fit of the lid onto the cup body, to provide a secure seal.

Patterning of nanostructures using imprint lithography

Various embodiments disclosed relate to methods of manufacturing a textured surface comprising disposing a nanoparticulate ink on a substrate.

Resource distribution instruments with embedded codes or communication devices

Embodiments of the invention are directed to facilitating electronic resource distribution by including computer-readable indicia or a short-range wireless tag on a physical resource distribution document/instrument that stores or provides access to instructions for requesting and/or processing subsequent resource distributions between the resource requester and requester provider fully electronically (i.e., absent the need for a resource distribution request document or a resource distribution document/instrument).

Medical valve

A valve for use in an endoscope may comprise a proximal valve stem member having a first lumen extending from a proximal opening at a proximalmost end of the proximal valve stem member to a distal opening at a distalmost end of the proximal valve stem member. A distal valve stem member may have a second lumen with a proximal opening at a proximalmost end of the distal valve stem member. The proximalmost end of distal valve stem member may be received within the distal opening of the first lumen. The distal valve stem may be movable relative to the proximal valve stem.

Olefin polymerization catalysts bearing a 6-amino-n-aryl azaindole ligand

Embodiments are directed to a metal-ligand complex of formula (I). In addition, a polymerization process includes polymerizing at least one olefin in the presence of a catalyst system comprising the metal-ligand complex and at least one activator to produce an olefinic polymer.

High temperature memory device

Disclosed herein are various nonvolatile integrated device embodiments suitable for use at high temperatures. In some embodiments, a high temperature nonvolatile integrated device comprises a sapphire or spinel substrate having multiple ferroelectric memory cells disposed upon it. In other embodiments, a high temperature nonvolatile integrated device comprises a silicon on insulator substrate or a large bandgap semiconductor substrate having multiple ferroelectric or magnetic memory cells disposed on it. In yet other embodiments, a high temperature nonvolatile integrated device comprises a sapphire, silicon on insulator, or a large bandgap substrate having programmable read only memory (PROM) cells or electrically erasable PROM (EEPROM) cells disposed on it.

Method and apparatus for remote control

Pumping breast milk

A breast pump provides multiple orientations of the pumping lever with respect to the breast shield. A breast pump includes a liner extending from the breast shield, through the suction chamber, and out of the suction chamber, which liner shields other components of the pump from contamination by the flow of milk through the pump during pumping operation. A breast pumping device includes a pumping lever for manually providing a cyclical vacuum within the suction chamber and an external pumping source, connected to the suction bell, that the user can activate to provide a cyclical vacuum within the suction chamber. A breast pump provides a smaller change in the grip width from when the lever is fully-extended to when the lever is fully-retracted, allowing more comfortable manual pumping.

High temperature environment tool system and method

In at least some embodiments, a tool may comprise a tool body and one or more tool components. The tool may further comprise tool electronics located within the tool body, wherein the tool electronics are operable to sense and store tool component characteristics and environmental characteristics. At least some of the tool electronics are operable, at least for one week, when exposed to temperatures of at least 200 Celsius. The tool electronics may be integrated circuits formed on a silicon carbide substrate or a silicon on sapphire substrate. One illustrative embodiment of the tool is a drill bit for employment in a high temperature drill well.

Method for producing polydienes with reduced cold flow

A process for preparing a polydiene having increased viscosity and reduced cold flow that includes polymerizing a conjugated diene monomer in the presence of a lanthanide-containing compound to form an intermediate polymer, and then adding a non-organometallic trimellitate ester compound as a coupling agent to raise the viscosity of the intermediate polymer. The coupling agent is added to the intermediate polymer mixture in an amount of about 0.01 to about 0.15 parts per hundred monomer (phm ) of the starting monomer amount.

Entry control system

Pumping breast milk

An apparatus for use in extracting milk from a human breast includes a pliant receiving member having an inner receiving portion sized to receive the human breast and an adjacent inner connecting portion defining an opening extending therethrough. The receiving member has an inner surface defining a recess located in the inner receiving portion and a passageway extending from the recess to the opening to provide fluid communication between the recess and the opening during use. The passageway provides fluid communication between the recess and the opening such that negative pressure can be generated between the recess and the breast.

Automated assembly device to tolerate blade variation

An automated device facilitates the assembly a surgical instrument that includes a knife with a high aspect ratio. The automated device includes a fixture for restraining a subassembly of the surgical instrument that includes the knife. A blade grip on the device is movable relative to the fixture, and is configured to urge the knife into a restrained position in the subassembly suitable for the subsequent assembly of an additional instrument component. A grip actuator is provided to move the blade grip.

Immunostimulatory rna/dna hybrid molecules

The present invention provides immunological compositions and methods relating to immunostimulatory intra-strand DNA/RNA hybrid oligonucleotides (HDRs), optimally encoding one or more CpG motif, which may be an unmethylated CpG motif. Administration of these compounds, alone or in the context of one or more target antigens, promotes innate and antigen specific immunities.

Immunostimulatory rna/dna hybrid molecules

The present invention provides immunological compositions and methods relating to immunostimulatory intra-strand DNA/RNA hybrid oligonucleotides (HDRs), optimally encoding one or more CpG motif, which may be an unmethylated CpG motif. Administration of these compounds, alone or in the context of one or more target antigens, promotes innate and antigen specific immunities.

Multiple pin connector having ferrite core stacked capacitor filter

EXPRESSION VECTORS

Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts

A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical structure corresponding to formula I: wherein R 1 is defined as wherein R 6 represents the carbon, hydrogen, and optionally one or more heteroatoms which, together with the nitrogen atom to which they are attached, constitute a 5 to 10 membered heterocyclic ring, which may be substituted or unsubstituted. R 2 , R 3 , R 4 , and R 5 , each independently represents a hydrogen atom, a substituted or unsubstituted alkyl having 1 to 6 carbon atoms, a substituted or unsubstituted alkenyl having 2 to 6 carbon atoms, or an alkynyl having 2 to 6 carbon atoms. Alternatively, R 2 and R 3 , when taken together, can represent the carbon, hydrogen, sulfur, nitrogen, or oxygen atoms necessary to complete a 5 to 7 membered heterocyclic ring with the nitrogen atom to which they are attached. Likewise, R 4 and R 5 , when taken together, can represent a similar heterocyclic ring. X − represents an acid anion (e.g., Cl − , Br − , F − , I − , PF 6 − , and BF 4 − ). Also in this method, a second moiety (e.g., a protein, a peptide, or a lipoprotein) is mixed with the first moiety. The first moiety and the second moiety react together to form a conjugate.

Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria

The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.

Oligodeoxynucleotide and its use to induce an immune response

D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X 1 X 2 X 3 Pu 1 Py 2 CpG Pu 3 Py 4 X 4 X 5 X 6 (W) M (G) N -3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.

Driver bit

Compounds that are ERK inhibitors

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Running board illumination system with passive marker light glow.

Se proporciona un sistema de iluminación de estribo para un vehículo de motor. El sistema de iluminación de estribo incluye un primer elemento de iluminación y una lente óptica para direccionar la luz emitida por el primer elemento de iluminación hacia un estribo del vehículo de motor. La lente óptica puede incluir además un recubrimiento fluorescente para proporcionar un brillo pasivo de luz indicadora cuando el primer elemento de iluminación se apaga.

Dual carrier immunogenic construct

A dual carrier immunogenic construct comprised of at least one primary carrier comprising large molecular weight molecule of greater than a 70 KD molecular weight and at least one secondary carrier comprising a T-dependent antigen conjugated to a primary carrier. The dual carrier immunogenic construct may further comprise moieties such as haptens and antigens. Such immunogenic constructs are suitable for use in the diagnosis, treatment, and prevention of diseases.

APPARATUS ONLY WIRELESS TRANSMITTER, REMOTE CONTROL TRANSMITTER OF MOBILE BARRIER ACTUATOR AND METHOD OF SELECTING TRANSMISSION FREQUENCY FOR SUCH APPARATUS

L'invention concerne un appareil seulement émetteur dans fil (20) qui comporte un dispositif de commande (21) réagissant à une interface (25) d'utilisateur en mettant en corrélation une entrée spécifique de l'utilisateur avec un ou plusieurs paramètres d'émission de caractérisation correspondants, stockées dans une mémoire (35) et en sélectionnant un dispositif résonant correspondant (31, 32). Ces derniers dispositifs servent à attaquer l'entrée de commande d'une boucle (23) à phase asservie pour agir ainsi sur la fréquence porteuse d'émission d'un émetteur sans fil (22).Domaine d'application : commande de barrières mobiles, etc. An in-wire transmitter-only apparatus (20) includes a controller (21) responsive to a user interface (25) by correlating a specific user input with one or more parameters. corresponding characterization emission, stored in a memory (35) and selecting a corresponding resonant device (31, 32). These latter devices are used to drive the control input of a phase-locked loop (23) in order to act on the transmission carrier frequency of a wireless transmitter (22). Field of application: control of mobile barriers , etc.

Wireless transmit-only apparatus for remote control of e.g. garage door, has control unit able to access parameters in memory so as to select particular resonance mechanism to use when transmitting particular transmission message

Apparatus (20) has a user interface (22) accessing a control unit (21) and activating mechanical resonance mechanisms (24, 25). Control unit interfaces with a memory (23) containing transmission characteristic parameters corresponding to transmission messages. Control unit accesses parameters so as to select particular resonance mechanism to use when transmitting particular transmission message. An independent claim is also included for a method for facilitating selection of a transmission frequency for a transmit-only apparatus.

Derivatives of indane and indoline and their use as activators of soluble guanylate cyclase

La presente invención proporciona un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo. un método para fabricar los compuestos de la invención, y sus usos terapéuticos. La presente invención además proporciona una combinación de agentes farmacologicamente activos y una composición farmacéutica.

APPARATUS AND METHOD FOR MOBILE BARRIER ACTUATOR RESPONDING TO AN OBSTACLE DETECTOR

L'invention concerne un actionneur (10) de barrière mobile ayant au moins deux modes de fonctionnement automatique. Ils différent l'un de l'autre en ce qui concerne des seuils d'une force maximale appliquée de manière que l'un des modes soit associé à un seuil réduit. Le choix entre ces seuils disponibles peut être basé, au moins en partie, sur le fait qu'un détecteur d'obstacle relié à une entrée (14) est connecté fonctionnellement à l'actionneur de la barrière mobile.Domaines d'application : commandes de barrières mobiles telles que des portes de garage, des volets roulants, des grilles coulissantes, etc. A movable barrier actuator (10) having at least two automatic modes of operation is disclosed. They differ from each other with respect to thresholds of a maximum applied force such that one of the modes is associated with a reduced threshold. The choice between these available thresholds can be based, at least in part, on the fact that an obstacle detector connected to an input (14) is functionally connected to the actuator of the mobile barrier. movable barriers such as garage doors, roller shutters, sliding gates, etc.

METHOD AND DEVICE FOR ACTIVATING A REMOTE CONTROL ACCESS SYSTEM

Pour actionner un système (210) d'accès par télécommande dans un véhicule à moteur (202) on détecte de façon non invasive la survenue d'un événement à bord faisant intervenir l'activation d'au moins un composant du véhicule à moteur. Un signal de commande est transmis au système d'accès (210) comme résultat de la détection de l'événement. To operate a remote control access system (210) in a motor vehicle (202), the occurrence of an on-board event involving the activation of at least one component of the motor vehicle is non-invasively detected. A control signal is transmitted to the access system (210) as a result of the detection of the event.

Tool bit

A tool bit includes a drive portion configured to be engaged by a tool, the drive portion including a first maximum outer dimension, a shank extending from the drive portion and including a reduced outer diameter, and a tip coupled to an end of the shank opposite from the drive portion. The tip includes a compressive residual stress layer formed by blasting to increase a wear resistance of the tip relative to the shank. The tip additionally includes a second maximum outer dimension. The reduced outer diameter of the shank is smaller than the first maximum outer dimension of the drive portion and the second maximum outer dimension of the tip.

Starch hemicellulose adhesive for high speed corrugating

Coupler resource module

A coupling assembly includes multiple composite substrate layers and a flange layer fusion bonded together in a stacked arrangement. The substrate layers are positioned on top of the flange layer and include embedded signal processing circuitry connected to a signal input and a signal output. A cavity is formed through an area of the substrate layers to expose signal connection terminals. These signal connection terminals are coupled to the embedded signal processing circuitry and they enable the addition of a circuit element to the assembly after the fusion bonding of the flange and substrate layers, and they enable the coupling of that added element to the signal processing circuitry.

Pyridyl tricyclic compounds as farnesyl protein transferase inhibitors and antitumor agents

Disclosed are novel tricyclic compounds represented by the formula (1.0) and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1Ø Also disclosed are methods of treating cancer using the compounds of formula 1Ø

Repositionable tissue-engagement member and associated systems and methods

A tissue-engagement member having a pair of jaws movable between a closed configuration and an open configuration, an actuator movable to shift the jaws between the closed and open configurations, and a biasing element biasing the jaws into a closed configuration. The biasing element may be provided over a portion of the tissue-engagement member. A cam mechanism may be provided in operative association with at least one of the jaws and/or the actuator. The biasing element may operatively engage at least one of the jaws and/or the actuator to actuate the cam mechanism to return the jaws to a closed configuration from an open configuration. A manipulator having an actuator-engagement element may be provided to engage an actuation element operatively associated with the actuator. The actuator-engagement element may operatively engage the actuation element in a range of orientations.

Pyridazine derivatives as rorc modulators

Compounds of formula (I): (I) or pharmaceutical salts thereof, wherein m, n,, p, q A, B, Ri, R2, R3, R4, R5, R6and R7are as defined herein. Also disclosed are methods of making the compounds and using the compounds as RORs modulators for treatment of inflammatory diseases such as arthritis.

Power apparatus for intermittently powered equipment

A back-up power supply for supplying operational power to a barrier movement apparatus when a mains supply of power is not present, includes an enabling circuitry (25) responsive to transmitted security codes for connecting operational power from the back-up power supply to the barrier movement apparatus (12). The back-up power supply includes a mains power input (13); a storage apparatus for storing power (17) from the mains supply; converting apparatus (23) for converting power stored by the storage apparatus into substitute mains power; and a control apparatus (12) responsive to user generated request signals for enabling the converting apparatus to convert stored power into substitute mains power for use by the equipment. In accordance with another aspect of the invention, when a controller of a barrier movement apparatus identifies that a power reduction by a substitute power supply was caused by the barrier striking an obstruction, the controller directs the opening of the barrier, away from the obstruction when power is returned.

COMPOSITION OF LIQUID, NON-WATER FABRIC TREATMENT AND PROCESS FOR ITS PRODUCTION

Population of cells enriched for myeloid and / or lymphoid progenitors and methods of preparation and use thereof

System and method of geospatially mapping topological regions and displaying their attributes

A geographical information system and a method are disclosed for geospatially mapping at least one parcel polygon within a geographical region and for displaying at least one specific attribute of each parcel polygon, i.e. a topological area within the given geographical region, as an attached attribute of latitude and longitude coordinates. The centroid or center point of each of the parcel polygons is determined and stored into conventional computer storage means. The latitude and longitude point feature at the centroid of each parcel polygon is established and similarly stored. A unique tax identification number, e.g. the Assessor Parcel Number (APN) or Parcel Identifier Number (PIN), is assigned to each of the point features. A correlation is then made between the unique tax identification number of the point feature to a text list of at least one attribute, e.g., the physical address of the parcel polygon, of each of the point features. This attribute becomes attached to each point feature. The resulting parcel polygon map and point features with one or more of the attached attributes can then be displayed within a GIS or CAD system to provide the user, for example, accurate locations of street addresses for use in environments that require pinpoint accuracy, such as emergency response.

Novel farnesyl protein transferase inhibitors as antitumor agents

Method and system for calibrating downhole tools for drift

A method and related system calibrating downhole tools for drift. Some of the illustrative embodiments are a logging tool comprising a tool body, a transmitter antenna associated with the tool body, a transmitter electronics coupled to the transmitter antenna, a first receiver antenna associated with the tool body, a first receiver electronics coupled to the first receiver antenna, and a signal generator separate from the first transmitter electronics, the signal generator coupled to the first receiver electronics, and the first signal generator provides a calibration signal to the first receiver electronics.

Oil well tool

Complement pathway modulators and uses thereof

The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Modulators of the complement path and uses thereof

La presente invención provee un compuesto de fórmula I: un método para fabricar los compuestos de la invención, y sus usos terapéuticos. La presente invención provee, además, una combinación de agentes farmacológicamente activos y una composición farmacéutica. The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Method and system for calibrating downhole tools for drift

A method and related system calibrating downhole tools for drift. Some of the illustrative embodiments are a logging tool comprising a tool body, a transmitter antenna associated with the tool body, a transmitter electronics coupled to the transmitter antenna, a first receiver antenna associated with the tool body, a first receiver electronics coupled to the first receiver antenna, and a signal generator separate from the first transmitter electronics, the signal generator coupled to the first receiver electronics, and the first signal generator provides a calibration signal to the first receiver electronics.

Cooking apparatus

Cytokines from natural killer or t cells

Cell-free preparations of a cytokine produced by natural killer (NK) cells activated with interleukin 2 (IL-2) or produced by CD4+ T cells activated with anti-CD3 monoclonal antibody are described. This cytokine induces antibody secretion by activated B cells. Methods for producing the cell-free supernatants containing the cytokine are also described.

Transmission and reception of an encrypted rolling code

A rolling code, used to operate barriers and the like, is encrypted by, in the embodiment described, mirroring all or a subset of the bits of the code. A section of the encrypted code is then selected and used to address a lookup table which stores data bit order patterns and data inversion patterns (figs. 9 and 10). A transmitted code comprises a portion made up of e.g. sync data and a portion made up of fixed and rolling code data (fig. 8). The fixed data and rolling code data are divided into groups (fig.7). The data bit order patterns are used to select one bit each from the groups specified in the bit order pattern, for transmission e.g. as a triplet. Ternary to binary conversion may be used. The bit inversion patterns specify which, if any, of the selected bits are to be inverted prior to transmission. Multiple groups (e.g. 10 in fig.8) are transmitted in this way. The sections of the encrypted code used to address the lookup table are included in the part of the transmitted message bearing sync data, for use at the receiver.

Breast pump and method of use

A breast pump convertible between a single breast pump mode and a double breast pump mode. The breast pump includes a pump and a conduit assembly coupled to the pump and at least one breast shield. The breast pump is operable to convert between the single breast pump mode and the double breast pump mode while maintaining substantially the same vacuum level applied to one of the breasts.

Cold plate refrigeration system optimized for energy efficiency

A Cold Plate Refrigeration System Optimized for Energy Efficiency is provided utilizing two refrigerant compressors and a single set of cold plates; or two refrigerant compressors, a conventional evaporator to air heat exchanger, and a single set of cold plates; or a single refrigerant compressor, a conventional evaporator to air heat exchanger, and a single set of cold plates. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Compositions and method for stimulating antibody release by b lymphocytes

The invention describes compositions comprising adding granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3), or a combination thereof useful for stimulating the release of antibody by B cells. Methods of using the compositions, pharmaceutical compositions, vaccines, and vaccines adjuvants are also described. In addition, this invention describes an assay system useful for identifying compounds capable of stimulating the release of antibody by B cells.

Apparatus for horologe with removable and interchangeable face

The present invention discloses a horologe, such as a watch or clock, in which a removable and interchangeable face can be removed from the horologe and easily replaced with another face without disconnecting components of the horologe or interfering with the horologe measuring time. In one embodiment, the horologe comprises a horological movement; a housing having a rim and a mount plate, a removable face for insertion into a faceplate compartment, and an inner transparent cover. A portion of the rim may be extendable away from the housing to reveal an opening to receive a removable face. In one embodiment, the horologe may comprise an extendable drawer, which is adapted for insertion into and selectably extendable from the faceplate compartment. In one embodiment, the horologe may comprise an outer bezel, which has open and closed positions for revealing and covering the opening of the faceplate compartment.

Remote control access system based upon the actuation of a component in a vehicle

A system and method of actuating a remote control access system in a motor vehicle (Fig. 1) non-invasively detects the occurrence of an event 505 involving an actuation of at least one component of a vehicle. A control signal is transmitted 514 to a remote control access system (e.g. to open a garage door) as a result of detecting the event (e.g. actuation of a light, brake, or heater, motion of a window, activation of a lock, movement of a mirror, radio control, roof opening, wiper blade, or setting a cruise control). A detection circuit for detecting the event can be connected to the transmitter circuit with a wire or wirelessly. The transmission of the control signal may additionally be dependent on the detected proximity of the vehicle to the remote access system, 504, 508.

Medical valve

A valve for use in an endoscope may comprise a proximal valve stem member having a first lumen extending from a proximal opening at a proximalmost end of the proximal valve stem member to a distal opening at a distalmost end of the proximal valve stem member. A distal valve stem member may have a second lumen with a proximal opening at a proximalmost end of the distal valve stem member. The proximalmost end of distal valve stem member may be received within the distal opening of the first lumen. The distal valve stem may be movable relative to the proximal valve stem.

Non-aqueous,nonionic heavy duty laundry detergent with improved stability using microspheres and/or vicinal-hydroxy compounds

Adaptive area of influence filter

An apparatus and method for enhancing image resolution

Pyridazine derivatives as RORc modulators

Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Medical systems, device, and related methods thereof

A medical device comprising a handle (120) extending between a first end and a second end, a first actuator (110) coupled to the first end of the handle, a first shaft (140) coupled to the second end of the handle, and a second shaft (150) extending from the first shaft, the second shaft including a first articulation section (170) and a second articulation section (160), wherein an articulation of the first actuator relative to the handle is configured to articulate the first articulation section, an articulation of the handle relative to the first shaft is configured to articulate the second articulation section, and the first articulation section and the second articulation section are restricted to articulating only in a first plane.

Valve

High temperature environment tool system and method

Luminescent hitch angle detection component.

En la presente se proporciona un sistema de iluminación para un remolque. El sistema de iluminación puede incluir un componente de detección del ángulo de enganche dispuesto en el remolque. Una fuente de luz se dispone en el vehículo. Una estructura fotoluminiscente se dispone en el componente de detección del ángulo de enganche y está configurada para tornarse luminiscente en respuesta a la excitación mediante la fuente de luz. El componente de detección del ángulo de enganche además puede incluir un patrón de imagen predeterminado de un cierto tamaño y una cierta forma proporcionado sobre la superficie superior del mismo para su captura por parte de un dispositivo de toma de imágenes y su reconocimiento por parte de una unidad de procesamiento de imágenes.

Treatment of malaria with farnesyl protein transferase inhibitors

Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.Also disclosed are novel Farnesyl Protein Transferase inhibitors.

Compositions and methods for treating bacteria

The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of treating (e.g., killing or inhibiting growth of) bacteria. For example, the present invention provides pharmaceutical compounds (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of using the same in research, therapeutic and drug screening applications.

High viscosity material pump having valved priming piston

A reciprocable liquid pump having a priming cylinder affixed beneath the lower valve housing, and a priming piston rod affixed to the lower end of the pump piston valve assembly. A priming piston and priming valve are affixed to the lower end of the priming piston rod, the priming piston being slidable over a limited range of movement along the priming piston rod and having a central opening with a beveled valve seat. The priming valve forms a conical valve surface which is engageable against the priming piston valve seat to provide a controllable flow path through the center opening of the priming piston.

Photoluminescent printed led molding.

Se divulga un aparato de iluminación configurado para sellar y adaptarse sustancialmente a una canaleta del techo de un vehículo. El aparato de iluminación comprende un primer electrodo conectado con una junta de la canaleta del techo por medio de un adhesivo. Una pluralidad de LEDs impresos configurados para emitir una primera emisión y suspendidos en una tinta semiconductora está dispuesta en una superficie del primer electrodo, y un segundo electrodo está conectado de manera conductora a la pluralidad de LEDs. Una capa fotoluminiscente está dispuesta en el segundo electrodo. El aparato de iluminación puede estar en comunicación con un controlador por medio del primer y el segundo electrodos, de modo tal que el controlador pueda activar selectivamente el aparato de iluminación.

Uronium salt conjugate vaccines

A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical structure corresponding to formula (I) wherein R1 is defined as (a), wherein R6 represents the carbon, hydrogen, and optionally one or more heteroatoms which, together with the nitrogen atom to which they are attached, constitute a 5 to 10 membered heterocyclic ring, which may be substituted or unsubstituted. R?2, R3, R4, and R5¿, each independently represents a hydrogen atom, a substituted or unsubstituted alkyl having 1 to 6 carbon atoms, a substituted or unsubstituted alkenyl having 2 to 6 carbon atoms, or an alkynyl having 2 to 6 carbon atoms. Atlernatively, R?2 and R3¿, when taken together, can represent the carbon, hydrogen, sulfur, nitrogen, or oxygen atoms necessary to complete a 5 to 7 membered heterocyclic ring with the nitrogen atom to which they are attached. Likewise, R?4 and R5¿, when taken together, can represent a similar heterocyclic ring. X- represents an acid anion (e.g., Cl?-, Br-, F-, I-, PF¿6-, and BF¿4?-). Also in this method, a second moiety (e.g., a protein, a peptide, or a lipoprotein) is mixed with the first moiety. The first moiety and the second moiety react together to form a conjugate.

Pressure-activated vibrating teether

A teething device is provided which includes a fluid-filled membrane sized to be at least partially received in the mouth of a child, a housing attached to the fluid-filled membrane, a handle sized to be grasped by a child, a vibrator configured to impart vibration to the fluid-filled membrane and a pressure switch selectively connecting the vibrator to a power source when a threshold pressure is applied to an outer surface of the membrane.

Secure spread spectrum-facilitated remote control signaling method and apparatus

Remote control signaling may be conveyed using a spread spectrum link and/or a non-spread spectrum link. Enabling link interfaces (such as corresponding transmitters, receivers, or transceivers) to support this flexibility are provided in a shared housing and couple as appropriate to a remote control signal platform. A corresponding apparatus may comprise a housing having disposed therein a first radio frequency transmitter such as a, spread spectrum transmitter and a second radio frequency transmitter such as a non-spread spectrum transmitter. This housing can further contain a remote control signal controller that operably couples to at least one of the first and second radio frequency transmitters. As another example, a corresponding apparatus may comprise a housing having disposed therein a first radio frequency receiver comprising a spread spectrum receiver and a second radio frequency receiver comprising a non-spread spectrum receiver.

Circuitry module

A circuit assembly includes multiple substrate with a regions of embedded signal processing circuitry can be connected to a region of adjustable signal processing circuitry and a cavity formed through an area of the substrate layers to expose signal connection terminals. These signal connection terminals are connected to the embedded signal processing circuitry and/or to the customizable circuitry and enables the addition of a circuit element to the assembly after the bonding of the substrate layers and enables the connection of that added element to the signal processing circuitry and to the adjustable rocessin circuitry.

Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them. 3488481_1 (GHMatters) P53372.AU.1

Garage door operator safety apparatus

Repositionable Tissue-Engagement Member And Associated Systems And Methods

A tissue-engagement member having a pair of jaws movable between a closed configuration and an open configuration, an actuator movable to shift the jaws between the closed and open configurations, and a biasing element biasing the jaws into a closed configuration. The biasing element may be provided over a portion of the tissue-engagement member. A cam mechanism may be provided in operative association with at least one of the jaws and/or the actuator. The biasing element may operatively engage at least one of the jaws and/or the actuator to actuate the cam mechanism to return the jaws to a closed configuration from an open configuration. A manipulator having an actuator-engagement element may be provided to engage an actuation element operatively associated with the actuator. The actuator-engagement element may operatively engage the actuation element in a range of orientations.

Luminescent hitch angle detection component.

En la presente se proporciona un sistema de iluminación para un remolque. El sistema de iluminación puede incluir un componente de detección del ángulo de enganche dispuesto en el remolque. Una fuente de luz se dispone en el vehículo. Una estructura fotoluminiscente se dispone en el componente de detección del ángulo de enganche y está configurada para tornarse luminiscente en respuesta a la excitación mediante la fuente de luz. El componente de detección del ángulo de enganche además puede incluir un patrón de imagen predeterminado de un cierto tamaño y una cierta forma proporcionado sobre la superficie superior del mismo para su captura por parte de un dispositivo de toma de imágenes y su reconocimiento por parte de una unidad de procesamiento de imágenes.

Human herpesvirus trimeric glycoprotein b, protein complexes comprising trimeric gb and their use as vaccines

The present disclosure provides modified human herpesvirus glycoprotein B (gB) proteins that incorporate unique mechanisms for generating proteins that mimic their native conformation to enhance their immunogenicity. The modified herpesvirus gB proteins insert a peptide linker at the furin cleavage site in the extracellular domain of herpesvirus gB. When expressed, the gB subunit associates in triplicate to produce a homotrimeric complex, mimicking the native conformation of the gB protein. Also provided are protein complexes comprising a homotrimeric complex of a modified herpesvirus gB protein and herpesvirus gH and gL proteins. Also provided are nucleic acids encoding the modified herpesvirus gB proteins, methods of inducing or suppressing an immune response in a subject by administering a vaccine comprising the modified helpesvirus gB protein, or nucleic acid encoding the same, or a protein complex comprising a homotrimeric complex of the modified herpesvirus gB protein and herpesvirus gH and gL proteins.

Cardholder verification rule applied in payment-enabled mobile telephone

A method includes equipping a mobile telephone with a payment capability, and storing a cardholder verification rule in the mobile telephone. The method further includes the mobile telephone applying the stored rule to determine whether to require a user of the mobile telephone to perform a cardholder verification process.

Printer's frame

Compounds derived from 1h-indole-4-yl-methyl- (benzofused heterocycle); pharmaceutical composition and combination; and use in the treatment of a disorder mediated by complement activation or the alternative route thereof.

Aminomethyl-biaryl derivatives complement factor D inhibitors and uses thereof

本發明提供式I化合物， □製造本發明化合物之方法及其治療用途。本發明進一步提供醫藥活性劑之組合及醫藥組合物。

Air spring vehicle suspension system

Power supply arrangement for intermittently powered equipment

Stütz-Energieversorgung zur Zufuhr von Betriebsenergie zu einer Barrierenbewegungsanordnung, wenn eine Hauptenergieversorgung nicht vorliegt, einschließlich einer Zulassungsschaltung, die anspricht auf gesendete Sicherheits-Codes zum Verbinden von Betriebsenergie von der Stütz-Energieversorgung zu der Barrierenbewegungsanordnung. Die Stütz-Energieversorgung schließt einen Hauptenergieversorgungseingang ein; eine Speichereinrichtung zum Speichern von Energie von der Hauptenergieversorgung; eine Umsetzeinrichtung zum Umsetzen von durch die Speichereinrichtung gespeicherte Energie in Ersatzversorgungsenergie und eine Steuereinrichtung, die anspricht auf benutzergenerierte Anforderungssignale zum Zulassen der Umsetzeinrichtung zum Umsetzen gespeicherter Energie in Ersatzversorgungsenergie zur Verwendung durch die Betriebseinrichtung. Wenn ein Controller einer Barrierenbewegungsanordnung erkennt, dass eine Energiereduzierung durch eine Ersatzenergieversorgung bewirkt worden ist durch das Auftreffen der Barriere auf ein Hindernis, veranlasst gemäß einem anderen Aspekt der Erfindung der Controller das Öffnen der Barriere, weggerichtet von dem Hindernis, wenn die Energie zurückkehrt. Auxiliary power supply for supplying operating energy to a barrier movement arrangement when a main energy supply is not present, including an admission circuit that is responsive to security codes sent to connect operating energy from the support energy supply to the barrier movement arrangement. The backup power supply includes a main power supply input; storage means for storing energy from the main power supply; a conversion device for converting energy stored by the storage device into replacement supply energy and a control device which responds to user-generated request signals for permitting the conversion device for converting stored energy into replacement supply energy for use by the operating device. According to another aspect of the invention, when a controller of a barrier ...

Thermoelectric heater and cooler unit for food

Clock control circuits, systems and methods

DIRECT CURRENT EMERGENCY POWER SUPPLY

Un dispositif d'actionnement de mouvement de barrière (11) ayant une source d'alimentation de secours (17) à courant continu est décrit. L'alimentation électrique du dispositif d'actionnement de mouvement de barrière envoie un courant continu d'intensité limitée à l'alimentation de secours (17) qui utilise le courant continu pour charger une batterie. La batterie est en circuit en permanence avec l'alimentation électrique du dispositif d'actionnement du mouvement de barrière au moyen d'une diode de puissance (43) et lorsqu'il se produit une coupure du secteur à courant alternatif, une alimentation à courant continu est fournie par la batterie (37) pour alimenter le dispositif d'actionnement de mouvement de barrière.

Battery control system

The system comprises first and second input terminals each adapted for connection to a source of charging power, first means for feeding power from the first input terminal to a first terminal of the rechargeable power source, second means for feeding power from the second input terminal to a second terminal of the rechargeable power source. Means are provided for sensing at least one condition of the rechargeable power source and for interrupting the first means for feeding power in response thereto. Third means are provided for feeding power from the rechargeable power source to the first input terminal. The third means includes means for bypassing at least a portion of the means for interrupting the first means for feeding power.

Ovate trigger dampening absorber

PYRIDYLOXY-INHIBITORS OF VEGF-R2 AND USE OF THE SAME FOR THE TREATMENT OF DISEASES

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDILOXI-INDOLES DE FORMULA (I) DONDE R1, R2, R3, R4, R7 Y R10 SON CADA UNO H O ALQUILO(C1-C6); R2 Y R4 TOMADOS EN COMBINACION FORMAN UN ENLACE; R5 ES H, ALQUILO(C1-C6) O HALOGENO; R6 ES HALOGENO O ALQUILO(C1-C6); X ES O O S; Z1 Y Z2 SON CADA UNO N O CR8, EN DONDE R8 ES H O ALQUILO(C1-C6); R9 ES (CR11R12)nNR13R14, (CR11R12)nOR15, ENTRE OTROS; R11 Y R12 SON CADA UNO H O ALQUILO(C1-C4); n ES DE 0 A 3; R13, R14 Y R15 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; Ar2 ES FENILO, NAFTILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3-TRIFLUORO-METIL-FENIL)-AMIDA DEL ACIDO 5-(7-ETIL-5,6,7,8-TETRAHIDRO-PIRIDO-[3,4-d]-PIRIMIDIN-4-ILOXI)-INDOL-1-CARBOXILICO; (4-FLUORO-3-TRIFLUORO-METIL-FENIL)-AMIDA DEL ACIDO 5-(6-METIL-AMINO-METIL-PIRIMIDIN-4-ILOXI)-INDOL-1-CARBOXILICO; (4-FLUORO-3-TRIFLUORO-METIL-FENIL)-AMIDA DEL ACIDO 6-TETRAZOL-2-IL-METIL-PIRIMIDIN-4-ILOXI)-INDOL-1-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO ENDOTELIAL VASCULAR (VEGF-R) SIENDO UTILES EN EL TRATAMIENTO DE RETINOPATIA DIABETICA, HEMANGIOBLASTOMA, NEFROPATIA DIABETICA, GLOMERULONEFRITIS REFERS TO COMPOUNDS DERIVED FROM PYRIDYLOXY-INDOLES OF FORMULA (I) WHERE R1, R2, R3, R4, R7 AND R10 ARE EACH H OR ALKYL (C1-C6); R2 AND R4 TAKEN IN COMBINATION FORM A LINK; R5 IS H, (C1-C6) ALKYL, OR HALOGEN; R6 IS HALOGEN OR ALKYL (C1-C6); X IS O O S; Z1 AND Z2 ARE EACH N O CR8, WHERE R8 IS H O ALKYL (C1-C6); R9 IS (CR11R12) nNR13R14, (CR11R12) nOR15, AMONG OTHERS; R11 AND R12 ARE EACH H O ALKYL (C1-C4); n IS 0 TO 3; R13, R14 AND R15 ARE EACH H, ALKYL (C1-C6), CYCLOALKYL (C3-C6), AMONG OTHERS; Ar2 IS PHENYLUS, NAPHTHYLUS, HETEROARYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (3-TRIFLUORO-METHYL-PHENYL) -AMIDE OF THE ACID 5- (7-ETHYL-5,6,7,8-TETRAHYDRO-PYRIDO- [3,4-d] -PYRIMIDIN-4-ILOXI) -INDOL-1-CARBOXYL; (4-FLUORO-3-TRIFLUORO-METHYL-PHENYL) -AMIDE OF THE ...

Resolution enhancement by nearest neighbor classified filtering