Houttuynia cordata derivatives and applications thereof in drug

The invention relates to houttuynia cordata derivatives or esters thereof, or an enantiomer or a diastereomer, stereomer, tautomer, hydate, solvate, predrug, or pharmaceutically acceptable salt. In addition, the invention further relates to a preparation method of the houttuynia cordata derivatives, and an application of the houttuynia cordata derivatives in a drug; and the invention further relates to a pharmaceutical composition of the compound, and applications in preparing an antibacterial and anti-virus drug especially used for treating various urinary system diseases, and the advantages are that the water solubility is good, the bioavailability is high, the purity is high, and the toxic and side effects and the stimulation effect due to low purity can be greatly reduced.

Abrasive machining method for ball end mill and four-shaft linkage equipment for abrasive machining

The invention discloses a method for grinding and machining a ball-nose end milling cutter and a four-axis coordinated grinding and machining device. In the grinding process, on the one hand the device leads a grinding wheel (8) to do rotary motion around a spindle and leads the ball-nose end milling cutter (9) to rotate around an axis X, on the other hand, the device leads the ball-nose end milling cutter (9) to translate along the axis X, at the same time, the device leads the ball-nose end milling cutter (9) to move along a horizontal axis Y which is vertical to the axis X and to move along an axis Z which is vertical to the axis X and the axis Y, thus forming the four-axis coordinated grinding and machining. The invention can clamp and grind as well as machine the ball-nose front knife surface and the circum front knife surface of the ball-nose end milling cutter in one time, thus realizing the grinding of all front and back knife surfaces on one special purpose machine tool. Compared ...

AUTOMATIC TYRE INFLATOR

The said automatic tyre inflator can inflate a running tyre. One scheme is that the ground presses the tyre to shift the pressure-adjusting ballon upwards, which compresses the pump ballon through a tappet to make air flow from the inflated pump ballon into the tyre. After compression, the pump ballon is mounted to the wheel axle and a cam fixed on the tyre bearing axle drives the tappet to compress the pump ballon for inflation. The said inflator makes it possible for a tyre with some leakage to maintain proper pressure for run.

Connecting machine

The invention discloses a connecting machine, which comprises a base frame (6), a lower die device (26), an upper die device (27) and a cylinder (31). The connecting machine is characterized in that: a lower plate (37) is arranged on the base frame (6); the lower die device (26) is arranged at the middle part of the lower plate (37); upright posts (36) are arranged at two ends of the lower plate (37); an upper plate (32) is arranged at the top end of the upright posts (36); the cylinder (31) is arranged at the upper side of the upper plate (32); the lower end of the cylinder (31) passes through the upper plate (32) and is connected with a pressure sensor (28); the pressure sensor (28) is arranged at the upper side of a middle plate (34), and two ends of the middle plate (34) are sleeved on the upright posts (36) through bearings (35); the upper die device (27) is arranged at the lower side of the middle plate (34); and the upper die device (27) is connected with the pressure sensor (28) ...

Portable rapid telescopic supporting post

The invention discloses a portable rapid telescopic supporting post, which comprises a supporting post body consisting of a plurality of sections of telescopic sleeves mutually connected. A nut is fixedly connected with the bottom of a first section of sleeve at the top end of the supporting post body, the a bottom cover is fixedly connected to the bottom of a second section of sleeve sleeved outside the first section of sleeve, and the bottom cover is fixedly connected with a screw rod connected with the nut; bottom covers provided with bottom cover holes are arranged on the bottoms of all section of sleeves at the lower part of the supporting post body, a supporting elastic board is arranged inside each sections of sleeves, and the initial end of each supporting elastic board is respectively connected with the inner wall of the corresponding sleeve; the bottom of each bottom cover is fixedly connected with a positioning pin corresponding to the bottom cover hole on the bottom cover of ...

Reliable seal dust discharging fixed ball valve

The invention discloses a ball valve in machinery field, in particular a reliable seal dust discharging fixed ball valve which comprises a valve body, a ball body, a valve cover, a valve seat, cylinders, a piston, piston rods and a ball valve driving device, wherein the ball valve driving device is positioned above the valve body and is connected with the valve body; the piston and the piston rods are positioned in the cylinder; the ball body is positioned in the valve body; the valve seat and the valve cover are connected slidingly; the valve seat is provided with an O-shaped seal ring and a valve seat seal ring which is connected with the O-shaped seal ring; the valve cover is distributed with a plurality of cylinders and a plurality of springs; the plurality of springs and piston rods are respectively pressed on the valve seat; and a soft backing ring is arranged between the valve seat and cylinder covers. According to the invention, the cylinders and the springs are respectively arranged ...

Automatic tyre inflator

Portable rapid telescopic supporting post

The invention discloses a portable rapid telescopic supporting post, which comprises a supporting post body consisting of a plurality of sections of telescopic sleeves mutually connected. A nut is fixedly connected with the bottom of a first section of sleeve at the top end of the supporting post body, the a bottom cover is fixedly connected to the bottom of a second section of sleeve sleeved outside the first section of sleeve, and the bottom cover is fixedly connected with a screw rod connected with the nut; bottom covers provided with bottom cover holes are arranged on the bottoms of all section of sleeves at the lower part of the supporting post body, a supporting elastic board is arranged inside each sections of sleeves, and the initial end of each supporting elastic board is respectively connected with the inner wall of the corresponding sleeve; the bottom of each bottom cover is fixedly connected with a positioning pin corresponding to the bottom cover hole on the bottom cover of ...

Bulb slotting cutter and its abrasive machining four-shaft linkage equipment

The invention discloses a bulb end milling cutter and a milling processing four-shaft associated device thereof. An S-shape bulb edge (1) is connected with a spiral circumferential edge (5), a bulb edge front face is connected smoothly with the circumferential edge front face (6), the bulb rear face (3) is connected with the circumferential edge rear face (7), and the bulb edge spiral groove (4) is connected with the circumferential edge spiral groove (8); the front angle of the bulb edge front face (2) is a rather big positive front angle, and is distributed with a small-big-small mode from inside to outside; the milling processing four-shaft associated device of the bulb end milling cutter comprises a latch bed (10), a horizontal longitudinal X axis straight-line motion flat stage (11), a horizontal transversal Y-axis straight-line motion flat stage (12), a vertical Z axis straight-line motion flat stage (13), a workpiece rotating shaft (14), and a front tool face milling head (15), and ...

Reliable seal dust discharging fixed ball valve

The invention discloses a ball valve in machinery field, in particular a reliable seal dust discharging fixed ball valve which comprises a valve body, a ball body, a valve cover, a valve seat, cylinders, a piston, piston rods and a ball valve driving device, wherein the ball valve driving device is positioned above the valve body and is connected with the valve body; the piston and the piston rods are positioned in the cylinder; the ball body is positioned in the valve body; the valve seat and the valve cover are connected slidingly; the valve seat is provided with an O-shaped seal ring and avalve seat seal ring which is connected with the O-shaped seal ring; the valve cover is distributed with a plurality of cylinders and a plurality of springs; the plurality of springs and piston rods are respectively pressed on the valve seat; and a soft backing ring is arranged between the valve seat and cylinder covers. According to the invention, the cylinders and the springs are respectively arranged ...

Method for analyzing content of enantiomer in N-formyl-L-leucine

The invention relates to a method for analyzing the content of enantiomers in N-formyl-L-leucine, which comprises the following steps of: respectively preparing a system adaptive solution, a test solution and a contrast solution, and injecting samples according to the sequence of a blank solution, the system adaptive solution, the contrast solution and the test solution, the mutual separation degree of an isomer chromatographic peak and a main peak in the chromatography is required to be greater than 1.5; the chromatographic conditions of the liquid chromatograph are as follows: an evaporative light-scattering detector is adopted; the temperature of the evaporative light scattering detector is 35-44 DEG C, the flow rate of nitrogen is 1.4-2.5 L/min, and the gain factor is 1.4-5.4. The analysis method solves the problems that a derivatization method is incomplete in conversion, long in reaction time consumption, complex in sample preparation, heating and other operation procedures before ...

Hollowed-out technology and sanitary towel

According to the hollowing-out technology, a flow guide surface layer is sequentially provided with a plurality of flow guide layer units in the conveying direction of the flow guide surface layer, and the flow guide layer units are provided with hollowing-out parts and pasting parts which are arranged at intervals in the conveying direction; the method comprises the following steps: S1, sequentially cutting hollow parts of flow guide layer units by a sheet moving assembly to form slices, and sucking up the slices; s2, glue is smeared on the pasting part; s3, after the slice moving assembly moves the slices in the step S1 to the pasting part in the same flow guide layer unit, the slices are pasted on the pasting part; s4, glue is smeared on the flow guide layer units; s5, sequentially cutting off and sucking up the attached and sliced diversion layer units by an integration assembly; s6, the integration assembly moves the flow guide layer units in the S5 and attaches the flow guide layer ...

Outdoor bodybuilding back beating machine

The invention discloses an outdoor bodybuilding back beating machine. The outdoor bodybuilding back beating machine comprises a back beating machine body, a beating device and a seat, wherein the back beating body is formed by connecting a bottom rod, a vertical rod, a vertical rod short joint and a cross rod in a surrounding way and is of a rectangular body structure, the upper part of a framework of the rectangular body structure is provided with the beating device, the beating device is mainly formed by beating hands, beating arms, beating hand rocking rods and a rocking rod, the rocking rod is divided into a first rocking rod and a second rocking rod, one end of each beating arm is connected with the corresponding beating hand, the other end of each beating arm is connected with the corresponding beating hand rocking rod, the beating hand rocking rods are connected with the first rocking rod, the first rocking rod and the second rocking rod are respectively connected with a second rocking ...

Drainage moisture absorption pad

The drainage moisture absorption pad comprises a pad body, the pad body comprises a top piece, an absorber and a bottom piece which are sequentially stacked from top to bottom, the periphery of the top piece is connected with the periphery of the bottom piece, the center line of the pad body extends in the front-back direction, and the absorber comprises a flow guide layer and a filling layer. The bottom faces of the left side and the right side of the flow guide layer are attached to the bottom piece, the middle of the flow guide layer protrudes upwards to be attached to the top piece, filling spaces are defined by the left side and the right side of the flow guide layer and the top piece, and the filling layer is located in the filling spaces. By changing the layer structure relation between the flow guide layer and the filling layer, the menstrual blood absorption and drainage effects are improved, the menstrual blood accumulation amount of the moisture absorption pad is reduced, liquid ...

Closing and machining equipment of self-locking nut

The invention discloses closing and machining equipment of a self-locking nut, which comprises a sliding feed component, a clamp component and a nut supporting component, and is characterized in that: the sliding feed component comprises a taper sleeve connecting sleeve (14) idly sleeved in a large sliding sleeve (5), a speed reducer (2) provided with a servo motor (1) and fixed on a bearing seat(3), and a screw rod (18) fixed on the taper sleeve connecting sleeve (14) through a screw rod nut (13) and connected with the speed reducer (2); the clamp component comprises a panel (6) fixed on the large sliding sleeve (5), a sliding groove disc (7) fixed on the panel (6), a pressing plate (9) connected with the sliding groove disc (7), a taper sleeve (10) connected with the taper sleeve connecting sleeve (14), and a pressing head (8) installed in a groove of the sliding groove disc (7); and the nut supporting component comprises a supporting rod (16) provided with a supporting head (17) and ...

Andrographolide compound and application of andrographolide compound in medicaments

The invention relates to an andrographolide derivative the structure of which is shown in a formula (I) or (II) and a stereoisomer, a stereomer, a tautomer, a solvate, a polymorph, a metabolin, ester, a pharmaceutically acceptable salt or a prodrug of the derivative. The andrographolide compound provided by the invention has the advantages of good solubility, high purity and good antipyretic property; and the andrographolide compound is especially suitable to be used as an effective component for preparing antipyretic, anti-inflammatory and antimicrobial medicaments.

Method for synthesizing 1-bromo-2,4,5-trifluorobenzene

The invention relates to a synthesis method of 1-bromine-2, 4, 5-trifluoro-benzene, which adds iron powder and 1, 2, 4-trifluoro-benzene into organic solvent, adds liquid bromine at 43-48DEG C in 3-4h, increases temperature to 62-68DEG C, adds azobisisobutyronitrile, mixes, reacts at 82-102DEG C completely to obtain reaction solution, to be purified to obtain 1-bromine-2, 4, 5-trifluoro-benzene. The mass ratio between the 1-bromine-2, 4, 5-trifluoro-benzene, liquid bromine, iron powder, and azobisisobutyronitrile is 1:0.5-1.5:0.025-0.050:0.002-0.006, the organic solvent is azobisisobutyronitrile or chloroform, of which the volume is 250-300ml/mol according to 1-bromine-2, 4, 5-trifluoro-benzene. Compared with prior synthesis method of 1-bromine-2, 4, 5-trifluoro-benzene, the invention hashigh yield, low cost, simple process and little environment pollution.

Bulb slotting cutter and its abrasive machining four-shaft linkage equipment

The invention discloses a bulb end milling cutter and a milling processing four-shaft associated device thereof. An S-shape bulb edge (1) is connected with a spiral circumferential edge (5), a bulb edge front face is connected smoothly with the circumferential edge front face (6), the bulb rear face (3) is connected with the circumferential edge rear face (7), and the bulb edge spiral groove (4) is connected with the circumferential edge spiral groove (8); the front angle of the bulb edge front face (2) is a rather big positive front angle, and is distributed with a small-big-small mode from inside to outside; the milling processing four-shaft associated device of the bulb end milling cutter comprises a latch bed (10), a horizontal longitudinal X axis straight-line motion flat stage (11),a horizontal transversal Y-axis straight-line motion flat stage (12), a vertical Z axis straight-line motion flat stage (13), a workpiece rotating shaft (14), and a front tool face milling head (15),and ...

Abrasive machininging method for ball end mill and four-shaft linkage equipment for abrasive machininging

The invention discloses a method for grinding and machining a ball-nose end milling cutter and a four-axis coordinated grinding and machining device. In the grinding process, on the one hand the device leads a grinding wheel (8) to do rotary motion around a spindle and leads the ball-nose end milling cutter (9) to rotate around an axis X, on the other hand, the device leads the ball-nose end milling cutter (9) to translate along the axis X, at the same time, the device leads the ball-nose end milling cutter (9) to move along a horizontal axis Y which is vertical to the axis X and to move along an axis Z which is vertical to the axis X and the axis Y, thus forming the four-axis coordinated grinding and machining. The invention can clamp and grind as well as machine the ball-nose front knife surface and the circum front knife surface of the ball-nose end milling cutter in one time, thus realizing the grinding of all front and back knife surfaces on one special purpose machine tool. Compared ...

Method for synthesizing 1-bromo-2,4,5-trifluorobenzene