PROCESS FOR COLOURING CERAMIC MATERIALS

THE INVENTION RELATES TO A NEW PROCESS FOR COLOURING CERAMIC MATERIALS BY USING AQUEOUS SOLUTIONS OF CHROMOPHORE IONS. IN PARTICULAR, CERTAIN TYPES OF SILICA ARE ADDED TO THE CERAMIC MIXES WHICH ARE TO BE COLOURED, AFTER WHICH AQUEOUS OR ORGANIC SOLUTIONS COMPRISING INORGANIC SALTS OF Fe (II) AND/OR Fe (III), OR ORGANIC DERIVATIVES OF Fe (II) AND/OR Fe (III) ARE APPLIED TO THE SURFACE OF THE SAID ADDITIVE - CONTAINING CERAMIC MIXES.

LED Lighting Device

A light emitting diode (LED) lighting device includes a light case, a plurality of heatsink, a plurality of LED modules and a plurality of power supplies. Each of the heatsink is connected with one of the LED modules and one of the power supplies correspondingly to form one LED light unit. The LED light units are assembled with the light case to form the LED lighting device.

Pharmaceutical Formulations of Biodegradable Biocompatible Camptothecin-Polymer Conjugates

A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.

Myotoxin-neutralizing peptides

The present invention relates to polypeptides having myotoxin-neutralizing properties and their use for treatment of envenomation. The present invention further relates to methods for neutralizing a venom using the polypeptide of the invention as well as to methods of treatment of envenomation by administering said polypeptide to a subject in need thereof.

Shortening just-in-time code warm up time of docker containers

According to one or more embodiments of the present invention, a computer-implemented method for shortening just-in-time compilation time includes creating a first container for executing a first computer program, the execution comprising generating, using a just-in-time compiler, a compiled code for a first code-portion of the first computer program. The method further includes storing the compiled code for the first code-portion in a code-share store. The method further includes creating a second container for executing a second computer program comprising a second code-portion. The method further includes determining that the second code-portion matches the first code-portion, and in response retrieving the compiled code from the code-share store for executing the second computer program.

Anti-lilrb antibodies and their use in detecting and treating cancer

The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.

WDM Mux/DeMux employing filters shaped for maximum use thereof

Filters shaped differently from those commonly used in WDM Mux/DeMux optical devices are described. Different from the prior art devices that commonly use filters shaped in cuboid, the filters in the embodiment of the present invention are shaped in parallelepiped. In other words, a cross section of such filter is not in parallelogram. According to one embodiment of the present invention, a filter is so cut that a cross section thereof presents a cutting angle not being 90 degrees. As a result, the filter is fully used in WDM Mux/DeMux optical devices. Such filters are advantageously used in compact optical modules. 1. An optical device comprising:an array of reflecting parts;an array of filters, each of the filters configured to allow a light beam at a selected wavelength to pass through, being a parallelepiped in shape, fully used to transmit a light beam at a selected wavelength, wherein each of the reflecting parts is positioned to correspond to one of the filters and redirects a light beam reflected from one of the filters to another one of the filters.2. The optical device as recited in claim 1 , wherein a cross section of the each of the filters presents a cutting angle not being 90 degrees at each of four corners of the cross section.3. The optical device as recited in claim 1 , wherein a cross section of the each of the filters is a parallelogram.4. The optical device as recited in claim 3 , wherein the parallelogram presents a cutting angle not being 90 degrees between two sides.5. The optical device as recited in claim 4 , wherein the reflecting parts and the filters are in a medium of refractive index n0 on a substrate and have a refractive index n claim 4 , the light beam is impinged upon one of the filters at an incident angle α claim 4 , a distance between the filters and mirrors is d.7. A method for configuring an optical device claim 4 , the method comprising:providing an array of reflecting parts;providing an array of filters, wherein each of the ...

Inter-platform information sharing system and method, server, computer storage medium

Disclosed is an inter-platform information sharing system, including an interface module, a control module and a database, wherein the interface module is configured to receive information obtained through a first platform and acquire the information from the database and synchronize the acquired information with the counterpart on a second platform, or receive information obtained through the second platform and acquire the information from the database and synchronize the acquired information with the counterpart on the first platform, and the control module is configured to control the interface module to receive the information and acquire the information from the database, and control the database to store the obtained information. In addition, an inter-platform information sharing method, a server and a computer storage medium are also provided.

Experimental method for coal desulfurization and deashing using permeation and solvating power of a supercritical fluid

An experimental method for coal desulfurization and deashing using permeation and solvating power of a supercritical fluid includes the following steps. The coal sample is ground and loaded into an extraction kettle with a cover. An inlet valve and an outlet valve of the extraction kettle are opened to circulate the supercritical CO2 fluid in the extraction kettle. The extraction kettle is sealed. By adjusting a temperature and a pressure in the extraction kettle, the supercritical CO2 fluid is kept at its critical point and permeates the coal sample to dissolve organic sulfur, inorganic sulfur and ash in the coal sample. The extraction kettle is depressurized, and the temperature in the extraction kettle is adjusted to gasify the supercritical CO2 fluid. The organic sulfur, the inorganic sulfur and part of the ash are separated from the supercritical CO2 fluid and precipitated at a bottom of the extraction kettle.

DEVICE, SYSTEM, AND METHOD FOR CREATING VIRTUAL CREDIT CARD

The present disclosure directs to method, device, system for creating virtual credit card. The method may include: acquiring a subset of real-name information from a user interface of a terminal device; searching the real-name information stored in the first server with the subset of the real-name information; upon the real-name information is found in the first server, sending the real-name user information to a second server; finding whether the real-name information associates with a credit card account stored in the second server; after finding the credit card account is stored in the second server, creating, by the second server, a virtual credit card account; and storing the virtual credit card associated with the virtual credit card account in the data storage of the first server. 1. A device for creating a virtual credit card comprising:a first server having a data storage containing pre-stored real-name information and associated electronic account information, wherein the first server is configured to:acquire a subset of real-name information from a user interface of a terminal device wherein the subset of the real-name information comprises at least a portion of a user name or identification number associated with the electronic account saved in the data storage;search for the real-name information stored in the data storage using the subset of the real-name information;send the real-name user information to a second server if the real-name information is found in the data storage;receive a notification from the second server if a credit card account stored in the second server associates with the real-name information, and a virtual credit card is created by the second server; andstore the virtual credit card associated with the virtual credit card account.2. The device of claim 1 , wherein the electronic account saved in the first server is one of: an electronic social account claim 1 , an electronic payment account claim 1 , an electronic game account ...

Thin film transistor and manufacturing method thereof, array substrate, display device and sensor

Provided is a thin film transistor including a highly-textured dielectric layer, an active layer, a gate electrode and a source/drain electrode that are stacked on a base substrate. The source/drain electrode includes a source electrode and a drain electrode. The gate electrode and the active layer are insulated from each other. The source electrode and the drain electrode are electrically connected to the active layer. Constituent particles of the active layer are of monocrystalline silicon-like structures. According to the present disclosure, the highly-textured dielectric layer is adopted to replace an original buffer layer to induce the active layer to grow into a monocrystalline silicon-like structure, such that the performance of the thin film transistor is improved.

1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors

Compounds having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).

Device and method for loading implant into delivery system

A device and method for loading an implant into a delivery system are disclose which are capable of simplifying operations required in interventional surgery using the implant. The device includes a guide cap ( 1 ), a guider ( 2 ) and a guiding tube ( 3 ). The guide cap ( 1 ) has a conical section ( 101 ) and a straight or conical tube ( 103 ) in communication with a small open end ( 102 ) of the conical section, and the conical section has a large open end ( 104 ) that flares outward, thereby forming a flange ( 105 ) facing the tube ( 103 ). The guider ( 2 ) has tapered sections ( 9, 10 ) that are tapered along an axis of the guider and thus form large and small open ends ( 8, 11 ). The small open end ( 11 ) has a diameter greater than a diameter of the small open end ( 102 ) of the conical section of the guide cap ( 1 ). The guide cap ( 1 ) and the guider ( 2 ) are so sized that the flange ( 105 ) can cover and be locked to the guider ( 2 ), with an end portion of the straight or conical tube ( 103 ) protruding from the small open end ( 11 ) of the guider ( 2 ). The guiding tube ( 3 ) is a round tube with two open ends, in which the first open end has a diameter greater than the diameter of the small open end ( 102 ) of the conical section of the guide cap and smaller than the diameter of the small open end ( 11 ) of the guider.

Liquid crystal display panel, manufacturing method thereof and display device

This disclosure provides a liquid crystal display panel. The liquid crystal display panel comprises: a first substrate and a second substrate arranged oppositely, a plurality of main spacers located between the first substrate and the second substrate for supporting cell gap of the liquid crystal display panel, a plurality of auxiliary spacers located between the first substrate and the second substrate, and a plurality of pressure sensing electrodes in one-to-one correspondence with the plurality of auxiliary spacers; wherein a height of the auxiliary spacer is smaller than a height of the main spacer; a material of the auxiliary spacer is a piezoelectric material. This disclosure also discloses a manufacturing method of the liquid crystal display panel and a display device comprising the liquid crystal display panel.

Guide cap and loading system for loading implant into delivery system

A guide cap and a loading system for loading an implant into a delivery system are disclosed which are capable of simplifying operations required in interventional surgery using the implant. The guide cap has a lumen passing therethrough and includes: a conical section; a straight or conical tube in communication with a small open end of the conical section; and a flange, wherein a large open end of the conical section flares outward and thereby forms the flange. The loading system includes a guider and the guide cap. During the process of loading the implant into the delivery system, the guide cap enables the valve prosthesis to be coupled to the connector of the delivery system and allows the valve prosthesis to be compressed so as to be entirely capsuled in the delivery system with relatively easy and quick operations, thereby reducing surgery time during its clinical use.

Poly(adp-ribose)polymerase inhibitors

Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.

Pyrrolopyrazine inhibitors of kinases

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1a , R 1b , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Cell adhesion-inhibiting antinflammatory compounds

Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.

Ink cartridge for ink-jet printer

An ink-jet mounting device of an ink-jet cartridge for an ink-jet printer including a carriage having a mounting portion in which an ink cartridge is removably mounted; a locking lever pivotably disposed at the carriage to lock and unlock the carriage mounted in the mounting portion; and a resilient member unit movably disposed in the carriage to pivot the ink cartridge by a predetermined angle by pushing the ink cartridge elastically.

Ink cartridge for ink-jet printer

An ink-jet mounting device of an ink-jet cartridge for an ink-jet printer including a carriage having a mounting portion in which an ink cartridge is removably mounted; a locking lever pivotably disposed at the carriage to lock and unlock the carriage mounted in the mounting portion; and a resilient member unit movably disposed in the carriage to pivot the ink cartridge by a predetermined angle by pushing the ink cartridge elastically.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having Formula Iare useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.

Data entry device

Diarylaminofluorene-based organometallic phosphors and organic light-emitting devices made with such compounds

The present invention provides a diarylaminofluorene chromophore compound having the following structure: wherein: M is a metal atom of Ir, Pt; R is H or any substituent such as CH 3 , OCH 3 , F; A is none or six-member aromatic ring system; m is at least 1; n is at least zero. The invention also provides high-efficiency organic light-emitting devices fabricated using these compounds.

Novel lilrb4 antibodies and uses thereof

The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

Chemical/mechanical system and method using two-phase/two-component compression heat pump

A heat pump system and method utilizes heat of mixing, in addition to the latent heat of solution, to increase cooling ability and thermal performance. The system includes a unique two-phase compressor for compressing a two-component mixture of liquid absorbent-refrigerant solution and superheated vapor to a high pressure. A generator extracts heat from the volume to be cooled by desorption and evaporation of the refrigerant from the high concentration solution in fluid connection with the inlet of the compressor. An absorber releases heat to surroundings by absorbing and condensing refrigerant vapor back into the liquid solution. A throttle valve controls the flow and reduces the pressure of the working fluid is in fluid connection with the absorber and the generator.

Electric vehicle system for charging and supplying electrical power

A power system that provides power between an energy storage device, an external charging-source/load, an onboard electrical power generator, and a vehicle drive shaft. The power system has at least one energy storage device electrically connected across a dc bus, at least one filter capacitor leg having at least one filter capacitor electrically connected across the dc bus, at least one power inverter/converter electrically connected across the dc bus, and at least one multiphase motor/generator having stator windings electrically connected at one end to form a neutral point and electrically connected on the other end to one of the power inverter/converters. A charging-sourcing selection socket is electrically connected to the neutral points and the external charging-source/load. At least one electronics controller is electrically connected to the charging-sourcing selection socket and at least one power inverter/converter. The switch legs in each of the inverter/converters selected by the charging-source/load socket collectively function as a single switch leg. The motor/generators function as an inductor.

1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors

1H-BENZIMIDAZOL-4-EFFECTIVE REPLACED CARBOXAMIDS AS INHIBITORS OF (PARP).

Un compuesto de Fórmula (I) **(Ver fórmula)** o una de sus sales terapéuticamente aceptables, donde R1, R2, y R3 se seleccionan independientemente del grupo que consiste en hidrógeno, alquenilo C2-C10, alcoxi C1-C10, (alcoxi C1-C10)carbonilo, alquilo C1-C10, alquinilo C1-C10, ciano, haloalcoxi C1-C10, haloalquilo C1-C10, halógeno, hidroxi, hidroxialquilo C1-C10, nitro, NRARB, y (NRARB)carbonilo; X1 es fenilo, donde X1 está sustituido opcionalmente con 1, 2, 3, o 4 sustituyentes seleccionados del grupo que consiste en alquilo C1-C10, ciano, halógeno, y haloalquilo C1-C10; W es X2-Y-NR6R7 o Y-NR6R7; X2 se selecciona del grupo que consiste en arilo y heteroarilo, donde arilo es fenilo o naftilo, y donde heteroarilo es benzotienilo, benzoxadiazolilo, cinolinilo, furopiridinilo, furilo, imidazolilo, indazolilo, indolilo, isoxazolilo, isoquinolinilo, isotiazolilo, naftiridinilo, oxadiazolilo, oxazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo, pirazolilo, pirrolilo, N-oxido de piridinio, quinolinilo, tetrazolilo, tiadiazolilo, tiazolilo, tienopiridinilo, tienilo, triazolilo, o triazinilo, donde X2 está sustituido opcionalmente con 1, 2, 3, o 4 sustituyentes seleccionados del grupo que consiste en alquilo C1-C10, ciano, halógeno, y haloalquilo C1-C10; Y es alquilenilo C1-C6; R6 se selecciona del grupo que consiste en hidrógeno, alquenilo C2-C10, alcoxi C1-C10-alquilo C1-C10, (alcoxi C1-C10)carbonilo, (alcoxi C1-C10)carbonil-alquilo C1-C10, alquilo C1-C10, alquinilo C1-C10,, fenilo, naftilo, cicloalquilo C3-C8, cicloalquil C3-C8-alquilo C1-C10, y hidroxialquilo C1-C10; R7 se selecciona del grupo que consiste en cicloalquilo C3-C8 y cicloalquilo C3-C8 fusionado a fenilo, donde R7 puede estar sustituido opcionalmente con 1, 2, o 3 sustituyentes seleccionados del grupo que consiste en alquenilo C2-C10, alcoxi C1-C10, alcoxi C1-C10-alquilo C1-C10, (alcoxi C1-C10)carbonilo, (alcoxi C1-C10)carbonil-alquilo C1-C10, alquilo C1-C10, (alquil C1-C10)carbonilo, (alquil C1- ...

Benzimidazole poly(ADP ribose)polymerase inhibitors

Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.

Inhibitors of poly(adp-ribose)polymerase

Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Inhibitors of poly(adp-ribose)polymerase

Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Pyrazoloquinolones are potent inhibitors for

PIRAZOLOQUINOLONAS SãO POTENTES INIBIDORES PARP. Compostos de Fórmula (1) inibem a enzima PARP e são úteis para tratar uma doença ou um distúrbio associado com PARP. São também reveladas composições farmacêuticas compreendendo compostos de Fórmula (1), métodos de tratamento compreendendo os compostos de Fórmula (1) e métodos de inibição da enzima PARP compreendendo os compostos de Fórmula (1). PIRAZOLOQUINOLONES ARE POWERFUL INHIBITORS PARP. Compounds of Formula (1) inhibit the PARP enzyme and are useful for treating a disease or disorder associated with PARP. Pharmaceutical compositions comprising compounds of Formula (1), methods of treatment comprising compounds of Formula (1) and methods of inhibiting the PARP enzyme comprising compounds of Formula (1) are also disclosed.

Inhibitors of poly(ADP-ribose)polymerase

Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Inhibitors of poly(ADP-ribose)polymerase

Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Compounds exhibiting glucagon antagonist and glp-1 agonist activity

Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.

Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity

Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.

Compounds exhibiting glucagon antagonist and glp-1 agonist activity

Patent JPH0250114B2

Lockset operable by pivoting actuator about a first axis or a second axis

A lockset is actuable by pivoting a handle about a longitudinal axis of the lockset by rotating the handle and by pivoting the handle about an axis transverse to the lockset axis, such as by pushing or pulling. The lockset includes an inside handle and an outside handle, each associated with an independent mechanism, each of which can independently actuate the lockset. A locking mechanism prevents actuation of a first one of the independent handle mechanisms without affecting operation of the other handle mechanism. Upon actuation of the other handle mechanism, a retractor engages a surface of the locking mechanism and removes it from engagement with the first locking mechanism. An adjustment ring has a first configuration that centers the lockset in a door having a first standard thickness and a second configuration that centers the lockset in a door having a second standard thickness.

Lockset operable by pivoting actuator about a first axis or a second axis

A lockset is actuable by pivoting a handle about a longitudinal axis of the lockset by rotating the handle and by pivoting the handle about an axis transverse to the lockset axis, such as by pushing or pulling. The lockset includes an inside handle and an outside handle, each associated with an independent mechanism, each of which can independently actuate the lockset. A locking mechanism prevents actuation of a first one of the independent handle mechanisms without affecting operation of the other handle mechanism. Upon actuation of the other handle mechanism, a retractor engages a surface of the locking mechanism and removes it from engagement with the first locking mechanism. An adjustment ring has a first configuration that centers the lockset in a door having a first standard thickness and a second configuration that centers the lockset in a door having a second standard thickness.

3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer

Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

9-substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Pyrazoloquinolones are potent parp inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Inclusion complexes of butyl phthalide with cyclodextrin derivatives and processes for their preparation

Delivery catheter and delivery device for artificial valve

A prosthetic valve delivery catheter and device. The delivery catheter (1) includes an outer sheath assembly and an inner sheath assembly. The outer sheath assembly includes a capsule (12) in which a prosthetic valve (3) can be received and an outer sheath (13) fixedly connected at one end to the capsule (12). The inner sheath assembly includes an inner sheath (15) and an anchor (14) fixedly connected to the inner sheath (15). The inner sheath assembly is arranged within a lumen of the outer sheath assembly, and the capsule (12) and the anchor (14) form a circumferentially indexed fit therebetween. With this design, the anchor (14) and the capsule (12) can be driven to rotate under the action of circumferential rotation of the inner sheath (15), thus the matching between the prosthetic valve and a native valve annulus can be adjusted. Moreover, the capsule (12) can be driven to move axially under actuation of the outer sheath (13) to allow release of the prosthetic valve (3).

Anti-lair1 antibodies and their uses

The present disclosure is directed to antibodies binding to LAIR 1 and their treating cancer, inflammation, immune-related diseases or transplantation.

9-REPLACED MINOCICLINE COMPOUNDS.

Un compuesto de minociclina de la fórmula I: En donde: R4'', R4", R7'' y R7" cada uno son alquilo (C1-5); y R9 es metilo que se sustituye con (a) un grupo de amino, (b) un grupo alquilamino (C1-6), (c) un grupo di (C1-6) alquilamino, o (d) un grupo alquilamino (C1-6)en el que el del grupo alquilamino (C1-6) se sustituye por fenilo, metilenedioxifenilo o para- perfluorometoxifenilo; Sales farmacéuticamente aceptables de estos, y prodrogas de estos en donde la porción de prodrogas se selecciona de porciones de éster de alquilo (C1-5), ésteres de alquenilo (C2-5), ésteres de di (C1-5) alquilamino (C1-5)-alquilo, ésteres de acilamino (C1-5) alquilo, ésteres de aciloxi (C1-5) alquilo, ésteres de arilo, ésteres de aril-(C1-5) alquilo, sustituido (con metilo, halo o sustituyentes metoxi), arilo y porciones de éster aril-(C1-5) alquilo, amidas (C1-5)-alquilo, amidas di-(C1-5) alquilo, y amidas hidroxi. A minocycline compound of the formula I: Where: R4 ", R4", R7 "and R7" each are (C1-5) alkyl; and R9 is methyl which is substituted with (a) an amino group, (b) an alkylamino (C1-6) group, (c) a di (C1-6) alkylamino group, or (d) an alkylamino (C1) group -6) in which that of the (C 1-6) alkylamino group is substituted by phenyl, methylenedioxyphenyl or para-perfluoromethoxyphenyl; Pharmaceutically acceptable salts thereof, and prodrugs thereof wherein the prodrug portion is selected from portions of alkyl ester (C1-5), alkenyl esters (C2-5), esters of di (C1-5) alkylamino (C1 -5) -alkyl, acylamino (C1-5) alkyl esters, acyloxy (C1-5) alkyl esters, aryl esters, aryl esters- (C1-5) alkyl, substituted (with methyl, halo or methoxy substituents ), aryl and portions of aryl- (C1-5) alkyl ester, (C1-5) -alkyl amides, di- (C1-5) alkyl amides, and hydroxy amides.

Flotation method for coal having poor floatation

A flotation method for a coal comprises: supplying, by means of a pump (E), a solution containing nanobubbles (5) to a mineral slurry mixing tank (F), and simultaneously supplying coal (7) and a flotation reagent (8) to the mineral slurry mixing tank (F); and supplying, by means of a material feeding pump (G), a mineral slurry mixture (9) to a countercurrent static micro-bubble flotation column (H) to undergo floatation, thereby obtaining two resulting products, a fine coal (10) and a tailing (11). The method utilizes a property of nanobubbles that the same preferentially gather at a hydrophobic surface, increasing the difference in hydrophobicity between the fine coal and coal gangue. The gathering of the nanobubbles also significantly reduces a fine mud covering a coal particle surface, thereby greatly reducing contamination caused by the fine mud, and increasing a recycling rate of the fine coal.

Data processing with tags

A source code defining record structure of data is received. The source code includes data tags which provide information for processing to be performed on the data. Data tagging metadata is generated based on the source code, and the data tagging metadata includes record structure information and the data tags. And data is processed according to the data tagging metadata.

Process for liberating and separating slack middling obtained from coking

The present invention relates to the technical field of coal liberation and separation. Disclosed is a process for liberating and separating difficult-to-separate high-ash slack middling obtained from a coking process. The technique comprises: crushing a slack middling feed (1) in a crushing apparatus (A); separating the crushed material using a spiral separator (B) which discards part of the material with higher density and feeds a lower density material into a particle mill (C); classifying the ground material with a three-product cyclone classifying screen (D), moving an overflow and an undersized material of the classifying screen (D) to a flotation separation system, and returning an underflow to the spiral separator (B) for another round of separation and liberation. The invention provides higher separation density. Spiral separation and discarding of a tailing prevents a high ash particle from entering the mill, thereby reducing the workload of the mill and preventing contamination of a fine coal caused by pulverization of the high ash particle.

Implant loading tool, compression device and loading system

The present invention provides a loading tool, a compression device and a loading system for an implant. The loading tool is configured to cooperate with a compression device to load an implant into a delivery device (5). The loading tool includes a protective tube (100) and a protective sleeve (200), the protective tube (100) is provided for the delivery device (5) to pass therethrough, and the protective sleeve (200) is detachably connected to the compression device through a first connecting portion, so that the protective tube (100) remains coaxial with the compression device. With such a configuration, the loading tool and the compression device are fixed stably and firmly, and the implant can be loaded by a single person, with high loading efficiency and simple operation.

Novel lilrb4 antibodies and uses thereof

The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

LED lamp having a convenient replacement structure

An LED lamp for providing a relatively large luminous flux, includes a housing and a pair of LED units mounted in the housing. The two LED units are separated from each other by a clapboard set in the housing. Each LED unit includes a plate, a plurality of LED modules disposed on the plate and a cover laying on the plate and cover the LED modules. The cover forms a plurality of vents to expose LEDs of the LED modules therein. A plurality of first screws extends through the LED modules and the plate to secure them together, while a plurality of second screws extends through the plate, the cover and the housing to fix the whole LED unit to the housing. Each LED module has a printed circuit board and a plurality of LEDs on the printed circuit board.

Electric handle for implant delivery and delivery system

Inhibitors of poly(ADP-ribose)polymerase

Utilizing zero-sequence switchings for reversible converters

A method for providing additional dc inputs or outputs ( 49, 59 ) from a dc-to-ac inverter ( 10 ) for controlling motor loads ( 60 ) comprises deriving zero-sequence components (V ao , V bo , and V co ) from the inverter ( 10 ) through additional circuit branches with power switching devices ( 23, 44, 46 ), transforming the voltage between a high voltage and a low voltage using a transformer or motor ( 42, 50 ), converting the low voltage between ac and dc using a rectifier ( 41, 51 ) or an H-bridge ( 61 ), and providing at least one low voltage dc input or output ( 49, 59 ). The transformation of the ac voltage may be either single phase or three phase. Where less than a 100% duty cycle is acceptable, a two-phase modulation of the switching signals controlling the inverter ( 10 ) reduces switching losses in the inverter ( 10 ). A plurality of circuits for carrying out the invention are also disclosed.

Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Device for emulsification and controlled addition of flotation agent

Disclosed is a device for the emulsification and controlled addition of a flotation agent, which is applicable to the field of coal dressing. The device comprises a floatation feed flow rate and concentration detection system (13), wherein a flotation machine feed pipeline is connected to a control system (14) through a line, and the control system (14) is connected to an agent metering, emulsification and multi-point addition system and a flotation foam product monitoring system, respectively; the control system (14) comprises a PLC control cabinet (12) and an upper computer (11) connected to each other; the agent metering, emulsification and multi-point addition system comprises an agent box, a metering pump (4), an emulsification pump (3), an agent addition metering pump (5) and an agent buffering tank (8); and the flotation foam product monitoring system is a monitoring camera (17) arranged on a flotation device (16), the monitoring camera (17) being connected to the upper computer (11). The device for the emulsification and controlled addition of a flotation agent realizes automatic addition of the agent, effectively reducing the waste of the agent, and no manual agent addition is required for the flotation machine, the flotation machine is unwatched so the need for manual work is reduced, and the floatation cost is reduced.

Lockset operable by pivoting actuator about a first axis or a second axis

A lockset is actuable by pivoting a handle about a longitudinal axis of the lockset by rotating the handle and by pivoting the handle about an axis transverse to the lockset axis, such as by pushing or pulling. The lockset includes an inside handle and an outside handle, each associated with an independent mechanism, each of which can independently actuate the lockset. A locking mechanism prevents actuation of a first one of the independent handle mechanisms without affecting operation of the other handle mechanism. Upon actuation of the other handle mechanism, a retractor engages a surface of the locking mechanism and removes it from engagement with the first locking mechanism. An adjustment ring has a first configuration that centers the lockset in a door having a first standard thickness and a second configuration that centers the lockset in a door having a second standard thickness.

Enabling a single context hardware system to operate as a multi-context system

Independent workloads may be grouped together into a single super workload. This super workload is dispatched to a single context hardware system that does not run an operating system. This effectively creates a multi-context system out of a single context hardware processor.

1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors

Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).

Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Inhibitors of poly(adp-ribose)polymerase

Inhibitors of poly (ADP-ribose)polymerase, ways to \make them and methods of treating patients using them are disclosed. No suitable figure

Cell adhesion-inhibiting antinflammatory compounds

Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.

Inhibitors of poly(adp-ribose)polymerase

Inclusion complexes of butylphthalide with cyclodextrin derivatives and processes for their preparation

Method for compiling page data, method, device and storage medium for page rendering

A page data compiling apparatus and method, the method being performed by a server, includes obtaining initial page structure data that is generated using an extended markup language, parsing the initial page structure data to generate scripting language page data comprising a page generation code and a data variable set, an input to the page generation code being a current data set that is determined according to the data variable set, and an output of the page generation code being a node tree matching the input current data set, and sending the scripting language page data to a terminal so that the terminal determines the current data set according to the data variable set, determines the matching node tree according to the current data set and the page generation code in the scripting language page data, and displays a page according to the node tree.

3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer

Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Pixel circuit including an ultrasonic recognition circuit, method for driving the same, and display panel

A pixel driving circuit and an ultrasonic line recognition circuit are coupled to a same power supply terminal, a same first control signal terminal and a same scanning signal terminal; and the ultrasonic line recognition circuit is coupled to an ultrasonic device, and the pixel driving circuit is coupled to a data signal terminal and a light emitting device.

Driving handle for conveying implant, and conveying system

Targeting lilrb4 with car-t or car-nk cells in the treatment of cancer

Lens, led module and illumination apparatus utilizing the same

An LED module includes an LED and a lens combined with the LED. The lens includes a light input face for light from the LED entering into the lens and a light output face refracting the light from the light input face. The light output face includes a first light output face continuously distributed thereon and a plurality of second light output faces inwardly recessed from the first light output face. The first light output face is a spheric face. The second light output faces can deflect the light extending therethrough toward a predefined area where the light extending through the first light output face is focused. An illumination apparatus utilizing the LED module is also provided.

Device for emulsification and controlled addition of flotation agent

Disclosed is a device for the emulsification and controlled addition of a flotation agent, which is applicable to the field of coal dressing. The device comprises a floatation feed flow rate and concentration detection system (13), wherein a flotation machine feed pipeline is connected to a control system (14) through a line, and the control system (14) is connected to an agent metering, emulsification and multi-point addition system and a flotation foam product monitoring system, respectively; the control system (14) comprises a PLC control cabinet (12) and an upper computer (11) connected to each other; the agent metering, emulsification and multi-point addition system comprises an agent box, a metering pump (4), an emulsification pump (3), an agent addition metering pump (5) and an agent buffering tank (8); and the flotation foam product monitoring system is a monitoring camera (17) arranged on a flotation device (16), the monitoring camera (17) being connected to the upper computer (11). The device for the emulsification and controlled addition of a flotation agent realizes automatic addition of the agent, effectively reducing the waste of the agent, and no manual agent addition is required for the flotation machine, the flotation machine is unwatched so the need for manual work is reduced, and the floatation cost is reduced.

Driving handle for delivering implant, and delivery system

A drive handle and system for delivering an implant are disclosed. The drive handle includes a manual control unit, an electrical control unit and a transmission mechanism. The manual control unit is connected to the transmission mechanism to actuate the transmission mechanism to drive a delivery catheter for delivering the implant. The electrical control unit is connected to the transmission mechanism to actuate the transmission mechanism to drive the delivery catheter. The drive handle is switchable between a manual drive/control mode and an electrical drive/control mode to drive the delivery catheter to deliver the implant. The operation is simple, and the operating physician can take full advantage of the two modes to perform the surgical procedure based on his/her own operational preferences. This can result in higher surgical accuracy. Further, by providing these two modes, the apparatus has an increased the security and a reduced surgical risk.

Fluorescent lamp driver power

A kind of fluorescent lamp driver power consists of the multi-switch converting circuit, power transformer, resonant inductor, resonant capacitor, step-up transformer and rectifier. The primary winding (PW) of the power transformer connects with the AC output of multi-switch converting circuit. The resonant inductor and resonant capacitor, after series connection, connect to the secondary winding (SW) of the power transformer through the PW of the step-up transformer. The SW of the power transformer connects with the rectifier. The SW of the step-up transformer connects with the load output. This invention combines the fluorescent lamp driver power and the power supply of the control system, so that the energy transformation occurs only once for the output from the Power Factor Correction (PFC) Circuit to lamp. By using this invention, the system cost is lowered greatly by saving two converters, working efficiency remarkably enhanced and system stability improved as well.

Polyphase wireless power transfer systems, coil assemblies and resonant networks

Polyphase wireless power transfer systems are provided. The transfer system may be used for charging hybrid and electric vehicles. The systems are capable of transferring over 50KW over an air gap of 15 cm. The systems use a rotating magnetic field to transfer power. The system may comprise transmitter coil assembly. The coil assembly may be one or more layers. The system may employ either unipolar or bipolar coils. The transmitter also comprises compensating capacitance connected in series with at least one coil for each phase. A value of the compensating capacitance for each phase is determined such that the transmitter has at least two independently excitable resonant modes at a resonant frequency. The transmitter is compatible with a plurality of different receivers including three-phase, single phase with a circular coil and single phase with DD coils.

Cell adhesion-inhibiting antinflammatory compounds

A találmány az (I) általános képletű vegyületekre, azok gyógyászatiszempontból elfogadható sóira és prodrugjaira (prekurzoraira)vonatkozik, ahol a képletben <-szimbólum egyszerű kötés vagy kettőskötés, azzal a megkötéssel, hogy ha az egyik kötés kettős kötés, akkora szomszédos kötés egyszerű kötés; E, F és G jelentése egymástólfüggetlenül szénatom, nitrogénatom vagy N+-O-csoport; Y és Z jelentéseegymástól függetlenül szén-, nitrogén-, oxigénatom vagy kéntartalmúcsoport; LA jelentése kovalens kötés, -O-, kéntartalmú vagynitrogéntartalmú csoport (szubsztituált aminocsoport); XA jelentésehalogénatom vagy 1-10 szénatomos alkilcsoport, amely adott esetben 1,2 vagy 3 szubsztituenst hordozhat; LB jelentése kovalens kötés, -O-,kéntartalmú vagy nitrogéntartalmú csoport; XB jelentése hidrogénatom,1-10 szénatomos, adott esetben 1, 2 vagy 3 szubsztituenst hordozóalkilcsoport, vagy adott esetben 1 vagy 2 szubsztituenst hordozó, 2-6szénatomos alkenilcsoport; Rl, R2, R3, R4 és R5 hiányoznak, vagyegymástól független jelentésük hidrogénatom, 1-6 szénatomos, adottesetben 1 vagy 2 szubsztituenst hordozó alkilcsoport, arilcsoport vagyheterociklusos csoport. A találmány szerinti hatóanyagokemlősállatokon a gyulladásos megbetegedések és reperfúziós károsodásokkezelésére alkalmazhatók. Ó The present invention relates to compounds of formula (I), their pharmaceutically acceptable salts and prodrugs, wherein the symbol is a single bond or a double bond, provided that when one bond is a double bond, the adjacent bond is a single bond; E, F and G are independently carbon, nitrogen or N + -O; Y and Z are each independently carbon, nitrogen, oxygen or sulfur; LA is a covalent bond, -O-, a sulfur-containing or a nitrogen-containing group (substituted amino); XA is halogen or (C 1 -C 10) alkyl optionally substituted with 1, 2 or 3 substituents; LB is a covalent bond, -O-, sulfur-containing or nitrogen-containing; XB is hydrogen, C 1 -C 10 alkyl optionally substituted with 1, 2 or 3 ...

Cell adhesion-inhibiting anti-inflammatory and immune-suppressive compounds

Anti-LILRB antibodies and their use in detecting and treating cancer

The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.

Proactive change verification

A computer-implemented method for proactive change verification is provided. Aspects include analyzing runtime execution characteristics from a plurality of base activity metrics and a plurality of experimental activity metrics and creating a plurality of activity pairs wherein each activity pair comprises a base activity metric and its corresponding experimental activity metric. Aspects also include identifying significant activity pairs from the plurality of activity pairs wherein the experimental activity significantly deviates from its corresponding base activity and classifying significant activity pairs by deviation type. Aspects further include sorting activity pairs by their impact and removing activity pairs that have an impact of less than a threshold amount, wherein the threshold amount is based on the deviation type. Aspects also include correlating interacting impactful activity pairs temporally and prioritizing impactful activity pairs using experimental activity deviations and displaying the impactful activity pairs.

Lithium metal negative electrode protection method improving lithium utilization efficiency

The invention discloses a lithium metal negative electrode protection method improving lithium utilization efficiency, and relates to the field of lithium batteries. In a lithium battery, lithium metal is deposited on a current collector as a battery negative electrode, and a high molecular polymer is added as an additive to an ester electrolyte. In the present application, the high molecular polymer is prepared by a polymerization reaction of monomer A being acrylonitrile or derivatives thereof, monomer B being perfluoroalkyl ethyl methacrylate or derivatives thereof, and monomer C being alkyl alcohol diacrylate or derivatives thereof. Due to the negative charge on the surface of lithium metal, the —CN and —CF3 in the polymer are strong electron-withdrawing groups, which promote the preferential adsorption of electrolyte additives on the surface of lithium metal and reduce the contact of other components in the electrolyte with lithium metal.

Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors

The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Implant capsule and implant delivery system

An implant capsule (10) and an implant delivery system are disclosed. The implant capsule (10) includes, sequentially from a proximal end to a distal end, a flexural section (102, 102a-102e), a reinforcement section (101, 101a-101e) and a radiopaque reinforcement ring (104a-104e). The reinforcement section (101, 101a-101e) has higher strength than the flexural section (102, 102a-102e). The implant delivery system includes the implant capsule (10). The implant capsule (10) can ensure the implant to be deployed in a coaxial condition and prevent over-expansion due to large expansion forces exerted by a stent of the implant.

Driving circuit, array substrate, display device and driving method

The present disclosure provides a driving circuit and a driving method thereof, an array substrate, a display device, and a driving method thereof. The driving circuit is applied for driving a light-emitting element and a fingerprint detection element, and includes: a driving sub-circuit, outputting a light-emitting driving current to the light-emitting element under the control of a driving node; a data writing sub-circuit, communicating a data input terminal with the driving node in response to a scanning signal of a scanning signal terminal; a first energy storage sub-circuit, coupled to the driving node and a control signal terminal; a detection sub-circuit, outputting a detection current under the control of an output terminal of the fingerprint detection element; and a data output sub-circuit, outputting a detection current to the data output terminal in response to the scanning signal of the scanning signal terminal.

Display substrate and manufacture method thereof, display panel

A display substrate, a manufacture method thereof and a display panel are provided. The display substrate includes: a first substrate; a plurality of pixel units included in the first substrate, each of the pixel units at least including a first sub-pixel unit, a second sub-pixel unit and a third sub-pixel unit; a medium film laminated layer arranged on the first substrate, the medium film laminated layer at least covering the first sub-pixel unit and the second sub-pixel unit; the medium film laminated layer is configured to eliminate blue light in a first wavelength range passing the medium film laminated layer, the medium film laminated layer includes at least one first medium film layer and at least one second medium film layer which are laminated alternately, and a refractive index of the first medium film layer is greater than a refractive index of the second medium film layer.

Novel lilrb4 antibodies and uses thereof

Encrypted signal detection circuit and video device using the same

A video device includes a video signal generation circuit, an encrypted signal detection circuit and a central processing unit (CPU). The encrypted signal detection circuit detects encrypted messages in video signals output from the video signal generation circuit and outputs stable trigger control signals to the CPU, which includes an amplifier circuit, a separation circuit, a reverse circuit, a delay circuit and a trigger circuit. The video signals are amplified via the amplifier circuit and negative phase pulse signals are extracted from the video signals via the separation circuit. The reverse circuit converts the negative phase pulse signals to positive phase pulse signals that are delayed via the delay circuit. The trigger circuit outputs the stable trigger control signals based on the delayed positive phase pulse circuit.

9-substituted minocycline compounds

Un compuesto de minociclina que tiene la siguiente fórmula: **(Ver fórmula)** en la que: R4', R4", R7' y R7" son cada uno alquilo C1-C5; R9 es metilo, etilo, i-propilo, n-propilo, alquilo sustituido, alquinilo no sustituido o sustituido, alcoxi, alquiltio, alquilsulfinilo, alquilsulfonilo, arilalquilo, arilalquinilo, tionitroso, alquilamino no sustituido o sustituido o -(CH2)1- 3NR9cC(>=Z')ZR9a, en el que dicho alquilo sustituido está sustituido con uno o más sustituyentes seleccionados del grupo que consiste en halógeno, alquilcarboniloxi, arilcarboniloxi, alcoxicarboniloxi, ariloxicarboniloxi, alquilaminocarbonilo, arilalquilaminocarbonilo, alquenilaminocarbonilo, alquenilcarbonilo, sililo, aminocarbonilo, alquiltiocarbonilo, fosfato, fosfonato, fosfinato, acilamino, amidino, imino, sulfhidrilo, alquiltio, ariltio, tiocarboxilato, sulfato, alquilsulfinilo, sulfonato, sulfamoilo, sulfonamido, nitro, azido, heterociclilo, alquilarilo, fenilo y heteroarilo; Z es CR9d R9e, S, NR9b u O; Z' es NR9f, O o S; y R9a es hidrógeno, acilo, alquilo no sustituido o sustituido, alquenilo no sustituido o sustituido, alquinilo no sustituido o sustituido, alcoxi no sustituido o sustituido, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilamino, arilalquilo, arilo no sustituido o sustituido, heterocíclico no sustituido o sustituido, heteroaromático no sustituido o sustituido; R9b, R9c, R9d, R9e y R9f son cada uno independientemente hidrogeno, acilo, alquilo, alquenilo, alquinilo, alcoxi, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilamino, arilalquilo, arilo, heterocíclico, heteroaromático; o un compuesto de minociclina seleccionado de entre los siguientes: **(Ver fórmulas)** y **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo. A minocycline compound having the following formula: ** (See formula) ** wherein: R4 ', R4 ", R7' and R7" are each C1-C5 alkyl; R9 is methyl, ethyl, i-propyl, n-propyl, substituted alkyl, ...

Inhibitors of poly(adp-ribose)polymerase

Cell adhesion-inhibiting anti-inflammatory and immunosuppressive compounds

Foreliggende oppfinnelse angår nye cinnamid-forbindelser som er anvendelige for behandling av inflammatoriske og immun-sykdommer, farmasøytiske preparater inneholdende disse forbindelser og metoder for hemning av inflammasjon eller undertrykking av immunrespons hos et pattedyr.

9-Substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Anti-LAIR1 antibodies and their uses

The present disclosure is directed to antibodies binding to LAIR 1 and their treating cancer, inflammation, immune-related diseases or transplantation.

Cell adhesion-inhibiting antinflammatory compounds

Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.

Anti-lair1 antibodies and their uses

The present disclosure is directed to antibodies binding to LAIR 1 and their treating cancer, inflammation, immune-related diseases or transplantation.

Led lamp

An LED lamp includes a monolithic housing made of metal extrusion and comprising a heat sink and a receiving portion integrally extending from a bottom of the heat sink, a plurality of LED modules attached to the heat sink, a cover covering the LED modules and a supporting bracket mounted on the housing. The heat sink includes a planar base and a plurality of fins extending from a top face of the base. The receiving portion includes a frame defining a window at a center thereof and two sidewalls interconnecting the frame and the base. The frame, the sidewalls and the base cooperatively define a receiving chamber for accommodating the LED modules therein. The LED modules are attached to the base and located corresponding to the window of the frame. The cover is mounted on a bottom of the frame and correspondingly covers the window.

Targeting lilrb4 with car-t or car-nk cells in the treatment of cancer

The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.

Cell adhesion-inibiting antiinflammatory and immunesuppressive compounds.